Shimizu Yukiko 清水有紀子

… Alternative Names

SHIMIZU YUKIKO 清水有紀子

SHIMIZU Yukiko 清水有紀子

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Researcher Number	00469983
Other IDs
Affiliation (Current)	2025: 国立健康危機管理研究機構, 国立国際医療研究所, 上級研究員
Affiliation (based on the past Project Information) *help	2020 – 2023: 国立研究開発法人国立国際医療研究センター, 研究所, 動物実験施設専任研究員 2016: 国立国際医療研究センター研究所, ヒト型動物開発研究室, 研究員 2016: 国立研究開発法人国立国際医療研究センター, 研究所設, 技術職員 2013: (独)国立国際医療研究センター研究所, 動物実験施設, 技術職員
Review Section/Research Field	Principal Investigator Basic Section 52050:Embryonic medicine and pediatrics-related Except Principal Investigator Laboratory animal science / Experimental pathology / Laboratory animal science
Keywords	Principal Investigator シスチノーシス / シスチン代謝関連因子 / 系統差 / シスチン代謝 / ライソゾーム / ラット / 希少疾患 / 早期診断 / 微量金属 / バイオマーカー … More Except Principal Investigator … More 抗肥満 / ラットモデル / 次世代シークエンサー / 肥満 / LEAラット / I型インターフェロン / 抗体 / 全身性エリテマトーデス / リソソーム / アミノ酸トランスポーター / シグナル伝達 / 免疫学 / マスト細胞 / Toll様受容体 / mTOR / トランスポーター / アレルギー / 自己免疫疾患 / 炎症 / (3) HPLC / (2) モデルラット / モデルラット / HPLC / リソソーム蓄積症 / シスチノーシス / シスチン蓄積症 / 疾患モデル Less

Novel regulatory mechanism of cystine metabolism in cystinosisPrincipal Investigator
- Principal Investigator
  
  清水有紀子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Global Health and Medicine
Development of biomarkers for early diagnosis in cystinosisPrincipal Investigator
- Principal Investigator
  
  Shimizu Yukiko
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 52050:Embryonic medicine and pediatrics-related
- Research Institution
  National Center for Global Health and Medicine
A novel regulatory mechanism of autoimmune disease pathogenesis by SLC15A4
- Principal Investigator
  
  Toyama-Sorimachi Noriko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Center for Global Health and Medicine
Genetic linkage analysis and identification of obesity-related gene in LEA rat
- Principal Investigator
  
  OKAMURA TADASHI
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  National Center for Global Health and Medicine
Establishment of a novel rat model for cystinosis
- Principal Investigator
  
  OKAMURA TADASHI
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Laboratory animal science
- Research Institution
  Research Institute, International Medical Center of Japan

All 2023 2022 2021 2020 2017 2015 2014 2013 2012 Other

All Journal Article Presentation Other

[Journal Article] d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats2020
- Author(s)
  Shimizu Yukiko、Ishii Chiharu、Yanobu-Takanashi Rieko、Nakano Kenta、Imaike Akio、Mita Masashi、Hamase Kenji、Okamura Tadashi
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
  
  Volume: - Issue: 9 Pages: 140463-140463
- DOI
  10.1016/j.bbapap.2020.140463
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K07149, KAKENHI-PROJECT-20K06479, KAKENHI-PROJECT-20K16943, KAKENHI-PROJECT-19J12809
[Journal Article] Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus.2017
- Author(s)
  Takahashi E, Unoki-Kubota H, Shimizu Y, Okamura T, Iwata W, Kajio H, Yamamoto-Honda R, Shiga T, Yamashita S, Tobe K, Okumura A, Matsumoto M, Yasuda K, Noda M, Kaburagi Y.
- Journal Title
  
  J Diabetes Investig.
  
  Volume: 印刷中 Issue: 5 Pages: 661-671
- DOI
  10.1111/jdi.12638
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04851, KAKENHI-PROJECT-26430101, KAKENHI-PROJECT-26670455
[Journal Article] The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.2014
- Author(s)
  Kobayashi T, Demoto-Shimabukuro S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N
- Journal Title
  
  Immunity
  
  Volume: 41 Issue: 3 Pages: 375-88
- DOI
  10.1016/j.immuni.2014.08.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-25871165, KAKENHI-PROJECT-26293090
[Journal Article] Phenotypic Characterization of LEA Rat: A New Rat Model of Nonobese Type 2 Diabetes2013
- Author(s)
  Okamura, T., Pei, XY., Miyoshi, I., Shimizu, Y., Takanashi-Yanobu, R., Mototani, Y., Takao Kanai, T., Satoh, J., Kimura, N. and Kasai, N
- Journal Title
  
  J Diabetes Res
  
  Volume: 2013 Pages: 986462-986462
- DOI
  10.1155/2013/986462
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500508, KAKENHI-PROJECT-24500495
[Journal Article] Quantitative assessment of pdx1 promoter activity in vivo using a secreted luciferase reporter system.2013
- Author(s)
  Nishimura, W., Eto, K., Miki, A., Goto, M., Kawaguchi, M., Nammo, T., Udagawa, H., Hiramoto, M., Shimizu, Y., Okamura, T., Fujiwara, T., Yasuda, Y. and Yasuda, K.
- Journal Title
  
  Endocrinology
  
  Volume: 154 Issue: 11 Pages: 4388-4395
- DOI
  10.1210/en.2012-2248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23500508, KAKENHI-PROJECT-23591330, KAKENHI-PROJECT-25870665
[Presentation] シスチン蓄積症（シスチノーシス）による腎障害について2023
- Author(s)
  片桐大輔、川村万里子、山本裕香、清水有紀子、岡村匡史
- Organizer
  第32回中国腎不全研究会学術集会
- Data Source
  KAKENHI-PROJECT-23K14964
[Presentation] シスチノーシス（シスチン蓄積症）に伴う角膜混濁から角膜びらんに至った１症例2023
- Author(s)
  山本裕香、岡村匡史、清水有紀子、丸山拓巳、片桐大輔、八代成子、永原幸
- Organizer
  第64回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-23K14964
[Presentation] シスチノーシスモデルマウスにおける系統差を用いたシスチン代謝修飾遺伝子の探索2022
- Author(s)
  清水有紀子、中野堅太、岡村匡史
- Organizer
  第69回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] マウス系統差を利用した新規シスチン代謝修飾遺伝子の探索2022
- Author(s)
  清水有紀子、中野堅太、後藤元人、岡村匡史
- Organizer
  第63回日本先天代謝異常学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] 小児ファンコニ症候群患者でのシスチノーシス検査の意義について2021
- Author(s)
  片桐大輔、清水有紀子、赤平百絵、山本祐香、岡村匡史
- Organizer
  第56回日本小児腎臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] Development of a two-dimensional LC-MS/MS system for the selective determination of intrinsic chiral amino acids and application to mammalian plasma2021
- Author(s)
  Chiharu ISHII, Yukiko SHIMIZU, Takeyuki AKITA, Masashi MITA, Tomomi IDE, Tadashi OKAMURA, Kenji HAMASE
- Organizer
  31st International Symposium on Pharmaceutical and Biomedical Analysis
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] LC/MSを用いた腎透析中シスチノーシス患者に対するシステアミン治療の有効性評価2021
- Author(s)
  岡村匡史、清水有紀子、片桐大輔、荒川玲子、山本裕香、赤平百絵
- Organizer
  第55回日本小児腎臓病学会学術集会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] 新規D-アミノ酸オキシダーゼ(Dao)遺伝子欠損ラットの樹立2020
- Author(s)
  清水有紀子、石井千晴、高梨-矢延理絵子、中野堅太、今池瑛生、浜瀬健司、岡村匡史
- Organizer
  第67回日本実験動物学会総会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] 透析患者におけるシスチノーシス検査の重要性2020
- Author(s)
  片桐大輔、清水有紀子、赤平百絵、岡村匡史
- Organizer
  第65回日本透析医学会学術集会・総会
- Data Source
  KAKENHI-PROJECT-20K16943
[Presentation] LEAラットにおける抗肥満遺伝子の探索2015
- Author(s)
  清水有紀子、高梨理絵子、岡村匡史
- Organizer
  第 62 回日本実験動物学会総会
- Place of Presentation
  京都
- Year and Date
  2015-05-28
- Data Source
  KAKENHI-PROJECT-26430101
[Presentation] 新規シスチン蓄積症モデルラットの樹立2014
- Author(s)
  清水有紀子, 他
- Organizer
  第61回日本実験動物科学技術 2014
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23500508
[Presentation] 新規シスチン蓄積症モデルラットの樹立2014
- Author(s)
  清水有紀子、高梨理絵子、金井孝夫、岡村匡史
- Organizer
  第61回日本実験動物科学技術2014
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23500508
[Presentation] 一体型多孔性シリカカラムを用いたシスチン定量法の開発とシスチン蓄積症モデルラットへの応用2012
- Author(s)
  清水有紀子、矢延―高梨理絵子、金井孝夫、笠井憲雪、浜瀬健司、岡村匡史
- Organizer
  第５９回日本実験動物学会総会
- Place of Presentation
  別府
- Data Source
  KAKENHI-PROJECT-23500508
[Presentation] 一体型多孔性シリカカラムを用いたシスチン定量法の開発とシスチン蓄積症モデルラットへの応用2012
- Author(s)
  清水有紀子, 他
- Organizer
  第59回日本実験動物学会総会
- Place of Presentation
  大分
- Data Source
  KAKENHI-PROJECT-23500508
[Presentation] 新規シスチン蓄積症モデルラットの樹立
- Author(s)
  清水有紀子、高梨理絵子、金井孝夫、岡村匡史
- Organizer
  第61回日本実験動物科学技術2014
- Place of Presentation
  札幌
- Year and Date
  2014-05-15 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26430101
[]

1. OKAMURA TADASHI (00333790)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. Toyama-Sorimachi Noriko (30217468)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. KOBAYASHI TOSHIHIKO (40613203)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. MATSUMOTO Michihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. DEMOTO Shiho

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. TANAKA Kaori

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. YOSHIDA Reiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shimizu Yukiko 清水 有紀子

SHIMIZU YUKIKO 清水 有紀子

SHIMIZU Yukiko 清水 有紀子

Research Projects

Research Products

Co-Researchers

Novel regulatory mechanism of cystine metabolism in cystinosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of biomarkers for early diagnosis in cystinosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel regulatory mechanism of autoimmune disease pathogenesis by SLC15A4

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Genetic linkage analysis and identification of obesity-related gene in LEA rat

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of a novel rat model for cystinosis

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] d-Amino acid oxidase deficiency is caused by a large deletion in the Dao gene in LEA rats2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The histidine transporter SLC15A4 coordinates mTOR-dependent inflammatory responses and pathogenic antibody production.2014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Phenotypic Characterization of LEA Rat: A New Rat Model of Nonobese Type 2 Diabetes2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Quantitative assessment of pdx1 promoter activity in vivo using a secreted luciferase reporter system.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] シスチン蓄積症（シスチノーシス）による腎障害について2023

Author(s)

Organizer

Data Source

[Presentation] シスチノーシス（シスチン蓄積症）に伴う角膜混濁から角膜びらんに至った１症例2023

Author(s)

Organizer

Data Source

[Presentation] シスチノーシスモデルマウスにおける系統差を用いたシスチン代謝修飾遺伝子の探索2022

Author(s)

Organizer

Data Source

[Presentation] マウス系統差を利用した新規シスチン代謝修飾遺伝子の探索2022

Author(s)

Organizer

Data Source

[Presentation] 小児ファンコニ症候群患者でのシスチノーシス検査の意義について2021

Author(s)

Organizer

Shimizu Yukiko 清水有紀子

SHIMIZU YUKIKO 清水有紀子

SHIMIZU Yukiko 清水有紀子