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HIYAMA AKIHIKO  檜山 明彦

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HIYAMA Akihiko  檜山 明彦

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Researcher Number 00514382
Other IDs
Affiliation (Current) 2025: 東海大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2025: 東海大学, 医学部, 准教授
2013 – 2019: 東海大学, 医学部, 講師
2012 – 2013: 東海大学, 医学部, 助教
2009 – 2010: Tokai University, 医学部, 助教
Review Section/Research Field
Principal Investigator
Orthopaedic surgery / Basic Section 56020:Orthopedics-related
Except Principal Investigator
Orthopaedic surgery
Keywords
Principal Investigator
椎間板変性 / Wntシグナル / 腰痛 / 腰痛の解明 / 分子学的解析 / 脊椎脊髄病学 / 腰痛治療薬 / 転写制御 / NGF / 神経栄養因子 … More / Wntシグナル / Cell signaling / CCN family / CCL20 / CCR6 / CCN family / NGF / 炎症性サイトカイン / ケモカイン / 創薬 / 分子学的研究 / EP受容体 / Wntシグナル / プロスタノイド / NF-κβ / 椎間板細胞 / EP受容体 / TNF-α / PGE2 / Wnt シグナル / Wntシグナル / VEGF / カルシウムシグナル / TonEBP / Intervertebral disc / NFAT / BMP2 / TGF-β / intervertebral disc / GlcAT-I … More
Except Principal Investigator
再生医学 / 再生医療 / 椎間板 / 創薬 / iPS細胞技術 / 脊椎脊髄病学 / 整形外科学 / 凍結保存 / 同種細胞移植 / 移植・再生医療 / iPS細胞 / インシリコ創薬 / iPS技術 / 転写因子 / 腰痛 / 椎間板再生 / 髄核細胞 / 椎間板変性 / 線維輪細胞 / 線維輪 / 幹細胞 Less
  • Research Projects

    (7 results)
  • Research Products

    (16 results)
  • Co-Researchers

    (5 People)
  •  IL-37を標的とした腰痛治療の新規抗炎症メカニズムの解明Principal Investigator

    • Principal Investigator
      檜山 明彦
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      Tokai University
  •  Analysis of transcription factors mediated by Wnt signal in intervertebral disc degeneration and search for therapeutic agents for low back painPrincipal Investigator

    • Principal Investigator
      HIYAMA Akihiko
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University
  •  Intervertebral disc regeneration and transcriptional control of nucleus pulpous progenitor cells by in silico pharmacogenesis and iPS technology

    • Principal Investigator
      SAKAI Daisuke
    • Project Period (FY)
      2016 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University
  •  Analysis of molecular mechanism of Wnt signal and arachidonic acid cascade in intervertebral disc degenerationPrincipal Investigator

    • Principal Investigator
      HIYAMA Akihiko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University
  •  Analysis of appropriate cell source for efficient annulus fibrosis regeneration

    • Principal Investigator
      SAKAI Daisuke
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University
  •  Pathogenesis of intervertebral disc degeneration and functional analysis of vascular endothelial growth factor (VEGF) in the intervertebral discPrincipal Investigator

    • Principal Investigator
      HIYAMA Akihiko
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University
  •  Molecular mechanisms involved in intervertebraldisc degeneration and potential new treatment strategiesPrincipal Investigator

    • Principal Investigator
      HIYAMA Akihiko
    • Project Period (FY)
      2009 – 2010
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Orthopaedic surgery
    • Research Institution
      Tokai University

All 2019 2017 2016 2015 2013 2012 2010 Other

All Journal Article Presentation

  • [Journal Article] Minimal Sustainability of Dedifferentiation by ROCK Inhibitor on Rat Nucleus Pulposus Cells In Vitro2019

    • Author(s)
      Nukaga Tadashi、Sakai Daisuke、Schol Jordy、Suyama Kaori、Nakai Tomoko、Hiyama Akihiko、Watanabe Masahiko
    • Journal Title

      Spine Surgery and Related Research

      Volume: 3 Issue: 4 Pages: 385-391

    • DOI

      10.22603/ssrr.2019-0019

    • NAID

      130007734403

    • ISSN
      2432-261X
    • Year and Date
      2019-10-27
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05456
  • [Journal Article] Response to tumor necrosis factor-α mediated inflammation involving activation of prostaglandin E2 and Wnt signaling in nucleus pulposus cells.2015

    • Author(s)
      Hiyama A
    • Journal Title

      J Orthop Res

      Volume: 33 Issue: 12 Pages: 1756-1768

    • DOI

      10.1002/jor.22959

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-26462252
  • [Journal Article] C-Fos Regulation by the MAPK and PKC Pathways in Intervertebral Disc Cells2013

    • Author(s)
      Yokoyama K1, Hiyama A, Arai F, Nukaga T, Sakai D, Mochida J
    • Journal Title

      PLoS One

      Volume: 8 Issue: 9 Pages: e73210-e73210

    • DOI

      10.1371/journal.pone.0073210

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592213
  • [Journal Article] A complex interaction between Wnt signaling and TNF-α in nucleus pulposus cells.2013

    • Author(s)
      Akihiko Hiyama
    • Journal Title

      Arthritis Res Ther

      Volume: 15

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791570
  • [Journal Article] Cell Signaling Pathways Related to Pain Receptors in the Degenerated Disk2013

    • Author(s)
      Hiyama A, Sakai D, Mochida J
    • Journal Title

      Global Spine Journal

      Volume: 3 Pages: 165-174

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592213
  • [Journal Article] The effects of oxygen tension and antiaging factor Klotho on Wnt signaling in nucleus pulposus cells.2012

    • Author(s)
      Hiyama A, Arai F, Sakai D, Yokoyama K, Mochida J.
    • Journal Title

      Arthritis Research and Therapy

      Volume: 14 Issue: 3

    • DOI

      10.1186/ar3830

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24592213
  • [Journal Article] The expression and role of non-canonical(PKC) signaling in nucleus pulposus cell metabolism2012

    • Author(s)
      Arai F, Hiyama A, Sakai D, Yokoyama K, Mochida J
    • Journal Title

      J Orthop Res

      Volume: 30(In press) Issue: 9 Pages: 1478-85

    • DOI

      10.1002/jor.22095

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22791406, KAKENHI-PROJECT-24592213
  • [Journal Article] The effects of oxygen tension and antiaging factor Klotho on the Wnt singaling in nucleus pulposus cells.2012

    • Author(s)
      Akihiko Hiyama
    • Journal Title

      Arthritis Res Ther.

      Volume: 14

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24791570
  • [Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012

    • Author(s)
      Abe, K. et al.
    • Journal Title

      Genesis

      Volume: 50 Issue: 10 Pages: 758-765

    • DOI

      10.1002/dvg.22035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21220010, KAKENHI-PROJECT-22500392, KAKENHI-PROJECT-22791388, KAKENHI-PROJECT-23300159, KAKENHI-PROJECT-23310135, KAKENHI-PROJECT-23592892, KAKENHI-PROJECT-23593038, KAKENHI-PROJECT-23700562, KAKENHI-PROJECT-24580411, KAKENHI-PROJECT-24592213, KAKENHI-PROJECT-221S0001, KAKENHI-PUBLICLY-24115712
  • [Journal Article] BMP-2 and TGFbeta Stimulate Expression of beta1,3 Glucuronosyl Transferase-1 (GlcAT-1) in Nucleus Pulposus Cells Through AP1, TonEBP and Sp1 : Role of Map Kinases.2010

    • Author(s)
      Hiyama A
    • Journal Title

      Journal of Bone Miner Res

      Volume: 25(5) Pages: 1179-90

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791419
  • [Journal Article] BMP-2 and TGFbeta Stimulate Expression of beta1,3 Glucuronosyl Transferase-I (G1cAT-I) in Nucleus Pulposus Cells Through AP1, TonEBP and Sp1 : Role of Map Kinases

    • Author(s)
      Hiyama A, et al
    • Journal Title

      Journal of Bone Miner Res 25(5)

      Pages: 1179-1190

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21791419
  • [Presentation] CCAAT/enhancer binding protein β Regulates the Expression of Tumor Necrosis Factor-α in the Nucleus Pulposus Cells2017

    • Author(s)
      Akihiko Hiyama
    • Organizer
      ORS 2017 Annual Meeting
    • Place of Presentation
      San Diego Convention Center (アメリカ・San Diego)
    • Year and Date
      2017-03-19
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462252
  • [Presentation] 椎間板細胞を用いたWntシグナルによるCCN familyの機能解析2017

    • Author(s)
      檜山明彦
    • Organizer
      第32回 日本整形外科基礎学術集会
    • Data Source
      KAKENHI-PROJECT-17K10945
  • [Presentation] 椎間板変性におけるWntシグナル伝達経路の活性制御と椎間板炎症2016

    • Author(s)
      檜山明彦
    • Organizer
      第31回日本整形外科基礎学術集会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-26462252
  • [Presentation] TGF-β/BMPシグナルはAP-1,TonEBPを介し椎間板内硫酸化グリコサミノグリカン代謝に関与する2010

    • Author(s)
      檜山明彦
    • Organizer
      第25回日本整形外科学会基礎学術集会
    • Place of Presentation
      国立京都国際会館(京都府)
    • Data Source
      KAKENHI-PROJECT-21791419
  • [Presentation] 炎症性サイトカインTNFαはNFκβとCOX-2/PGE2 経路を介しWntシグナルを発現制御する

    • Author(s)
      檜山 明彦
    • Organizer
      第29回 日本整形外科基礎学術集会
    • Place of Presentation
      鹿児島
    • Year and Date
      2014-10-09 – 2014-10-10
    • Data Source
      KAKENHI-PROJECT-26462252
  • 1.  SAKAI Daisuke (10408007)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 4 results
  • 2.  MOCHIDA Joji (30129697)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 3.  NAKAI Tomoko (20624589)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  平山 令明 (70238393)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  升井 伸治 (20342850)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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