SHIROTA Matsuyuki 城田松之

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Shirota Matsuyuki 城田松之

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Researcher Number	00549462
Other IDs
Affiliation (Current)	2023: 東北大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2018 – 2022: 東北大学, 医学系研究科, 講師 2016 – 2017: 東北大学, 医学系研究科, 助教 2016: 東北大学, 大学院医学系研究科, 助教 2014 – 2015: 東北大学, 医学(系)研究科(研究院), 助教
Review Section/Research Field	Principal Investigator Life / Health / Medical informatics / Basic Section 43060:System genome science-related / Complex systems / Basic Section 62010:Life, health and medical informatics-related Except Principal Investigator Basic Section 50010:Tumor biology-related / Tumor biology / Molecular biology / Genome biology / General medical chemistry / Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
Keywords	Principal Investigator 蛋白質構造 / 蛋白質立体構造 / データベース / 水素結合 / 二次構造 / RNA-seq / タンパク質立体構造 / ゲノムバリアント / 進化的保存 / データベース開発 … More / 構造予測 / アミノ酸配列 / シミュレーション / リファインメント / データベース解析 / 分子動力学シミュレーション / 経験的評価関数 / 立体構造予測 / 機能欠失変異 / ゲノム配列変化 / 蛋白質機能 / 非同義置換 / 機能解析 / ゲノム / 塩基配列変化 / マイクロエクソン / 選択的スプライシング / ゲノムワイド関連解析 / 高次機能 / タンパク質構造 / 制御領域 / 遺伝子発現 / スプライシング … More Except Principal Investigator 中心体 / がん / がん関連分子 / ヒストン修飾 / BRCA1 / ゲノム安定性維持 / 細胞分裂 / 癌 / ゲノム編集 / CRISPR/Cas9システム / 超並列シークエンス解析 / 腫瘍形成能 / Geminin / エピゲノム / 細胞周期 / ES細胞 / Cdt1 / エピゲム / 転写制御 / MLL2 / エピジェネティクス / 転写 / エンハンサー / CRISPR/Cas9 / ポリコーム / RNAポリメラーゼ / 修飾酵素 / H3K27me3 / H3K36me3 / DRB / 遺伝子増幅 / TGF-β刺激 / Myc遺伝子 / シグナル伝達経路 / DNA損傷応答 / DNA損傷 / ゲノム不安定性 / がん治療 Less

中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発
- Principal Investigator
  
  千葉奈津子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Prediction and validation of regulatory variants based on DNA/RNA-protein complex structuresPrincipal Investigator
- Principal Investigator
  
  城田松之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Tohoku University
Multi-layer informatics analysis on brain and personality focused on microexonsPrincipal Investigator
- Principal Investigator
  
  城田松之
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Tohoku University
Development of Targeting therapy for centrosome dysregulation in cancer
- Principal Investigator
  
  Chiba Natsuko
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Tohoku University
Development of information system for functional annotation of genomic sequence alterations by using protein 3D structuresPrincipal Investigator
- Principal Investigator
  
  Shirota Matsuyuki
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43060:System genome science-related
- Research Institution
  Tohoku University
Elucidation of the signaling pathways that induce gene amplification
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 43:Biology at molecular to cellular levels, and related fields
- Research Institution
  Tohoku University
Elucidation of the mechanism of transcription elongation rate control by histone code
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  Tohoku University
Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapy
- Principal Investigator
  
  CHIBA Natsuko
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Tumor biology
- Research Institution
  Tohoku University
Verification of genomic diversity required for tumorigenesis
- Principal Investigator
  
  NAKAYAMA Keiko
- Project Period (FY)
  2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Molecular biology
- Research Institution
  Tohoku University
Refinement of protein structure prediction by using simulation and database analysesPrincipal Investigator
- Principal Investigator
  
  Shirota Matsuyuki
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Tohoku University
Genome wide analysis of epigenetic regulation of enhancer activity via H3K27 modifications
- Principal Investigator
  
  HOSOGANE Masaki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Genome biology
- Research Institution
  Tohoku University
Development of a database of buried polar residues in protein structuresPrincipal Investigator
- Principal Investigator
  
  Shirota Matsuyuki
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  Tohoku University

All 2021 2020 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] BRCA1/ATF1-mediated transactivation is involved in resistance to PARP inhibitors and cisplatin2021
- Author(s)
  Endo S, Yoshino Y, Shirota M, Watanabe G, and Chiba N
- Journal Title
  
  Cancer Research Communications
  
  Volume: 1(2) Pages: 90-105
- DOI
  10.1158/2767-9764.crc-21-0064
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19H03493
[Journal Article] Biallelic variants/mutations of IL1RAP in patients with steroid-sensitive nephrotic syndrome.2020
- Author(s)
  Niitsuma Sou、Kudo Hiroki、Kikuchi Atsuo、Hayashi Takaya、Kumakura Satoshi、Kobayashi Shuhei、Okuyama Yuko、Kumagai Naonori、Niihori Tetsuya、Aoki Yoko、So Takanori、Funayama Ryo、Nakayama Keiko、Shirota Matsuyuki、Kondo Shuji、Kagami Shoji、Tsukaguchi Hiroyasu、Iijima Kazumoto、Kure Shigeo、Ishii Naoto
- Journal Title
  
  Int Immunol.
  
  Volume: 32 Pages: 283-292
- DOI
  10.1093/intimm/dxz081
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K09719, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18H02572, KAKENHI-PROJECT-17K08875, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-19H03612, KAKENHI-PROJECT-18KK0244
[Journal Article] Metabolic and pathologic profiles of human LSS deficiency recapitulated in mice2020
- Author(s)
  Wada Yoichi、Kikuchi Atsuo、Kaga Akimune、Shimizu Naoki、Ito Junya、Onuma Ryo、Fujishima Fumiyoshi、Totsune Eriko、Sato Ryo、Niihori Tetsuya、Shirota Matsuyuki、Funayama Ryo、Sato Kota、Nakazawa Toru、Nakayama Keiko、Aoki Yoko、Aiba Setsuya、Nakagawa Kiyotaka、Kure Shigeo
- Journal Title
  
  PLOS Genetics
  
  Volume: 16
- DOI
  10.1371/journal.pgen.1008628
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-17K10044, KAKENHI-PROJECT-18K19281
[Journal Article] Cancer-associated fibroblasts secrete Wnt2 to promote cancer progression in colorectal cancer2019
- Author(s)
  Aizawa Takashi、Karasawa Hideaki、Funayama Ryo、Shirota Matsuyuki、Suzuki Takashi、Maeda Shimpei、Suzuki Hideyuki、Yamamura Akihiro、Naitoh Takeshi、Nakayama Keiko、Unno Michiaki
- Journal Title
  
  Cancer Medicine
  
  Volume: 8 Pages: 6370-6382
- DOI
  10.1002/cam4.2523
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09065, KAKENHI-PROJECT-19K09188, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18K19281
[Journal Article] Recurrent de novo MAPK8IP3 variants cause neurological phenotypes2019
- Author(s)
  Iwasawa Shinya、Yanagi Kumiko、Kikuchi Atsuo、Kobayashi Yasuko、Haginoya Kazuhiro、Matsumoto Hiroshi、Kurosawa Kenji、Ochiai Masayuki、Sakai Yasunari、Fujita Atsushi、Miyake Noriko、Niihori Tetsuya、ら
- Journal Title
  
  Annals of Neurology
  
  Volume: － Pages: 927-933
- DOI
  10.1002/ana.25481
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-18K07863, KAKENHI-PROJECT-18K19281, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19K08281, KAKENHI-PROJECT-19K08289, KAKENHI-PROJECT-17H01539
[Journal Article] Detection of NRAS mutation in cell-free DNA biological fluids from patients with kaposiform lymphangiomatosis.2019
- Author(s)
  Ozeki Michio、Aoki Yoko、Nozawa Akifumi、Yasue Shiho、Endo Saori、Hori Yumiko、Matsuoka Kentaro、Niihori Tetsuya、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Fukao Toshiyuki
- Journal Title
  
  Orphanet J Rare Dis.
  
  Volume: 14 Pages: 215-215
- DOI
  10.1186/s13023-019-1191-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-18K15704
[Journal Article] Germline-Activating RRAS2 Mutations Cause Noonan Syndrome2019
- Author(s)
  Niihori Tetsuya、Nagai Koki、Fujita Atsushi、Ohashi Hirofumi、Okamoto Nobuhiko、Okada Satoshi、Harada Atsuko、Kihara Hirotaka、Arbogast Thomas、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Abe Taiki、Inoue Shin-ichi、Tsai I-Chun、Matsumoto Naomichi、Davis Erica E.、Katsanis Nicholas、Aoki Yoko
- Journal Title
  
  The American Journal of Human Genetics
  
  Volume: 104 Pages: 1233-1240
- DOI
  10.1016/j.ajhg.2019.04.014
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KK0228, KAKENHI-PUBLICLY-18H04795, KAKENHI-PROJECT-17H01539, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-19H03620, KAKENHI-PROJECT-17K10045, KAKENHI-PROJECT-18K19281, KAKENHI-PROJECT-18K15657, KAKENHI-PROJECT-17H04223
[Journal Article] Rett-like features and cortical visual impairment in a Japanese patient with HECW2 mutation2018
- Author(s)
  Nakamura Haruhiko、Uematsu Mitsugu、Numata-Uematsu Yurika、Abe Yu、Endo Wakaba、Kikuchi Atsuo、Takezawa Yusuke、Funayama Ryo、Shirota Matsuyuki、Nakayama Keiko、Niihori Tetsuya、Aoki Yoko、Haginoya Kazuhiro、Kure Shigeo
- Journal Title
  
  Brain Dev
  
  Volume: 40 Pages: 410-414
- DOI
  10.1016/j.braindev.2017.12.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04035
[Journal Article] The BRCA1-interacting protein OLA1 requires the interaction with BARD1 to regulate centrosome number.2018
- Author(s)
  Yoshino Y, Qi H, Fujita H, Shirota M, Abe S, Komiyama Y, Shindo K, Nakayama M, Matsuzawa A, Kobayashi A, Ogoh H, Watanabe T, Ishioka C and Chiba N.
- Journal Title
  
  Molecular Cancer Research
  
  Volume: 6(10) Pages: 1499-1511
- DOI
  10.1158/1541-7786.mcr-18-0269
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-16K07296
[Journal Article] Bone Marrow PDGFRalpha+Sca-1+ Enriched Mesenchymal Stem Cells Support Survival of and Antibody Production by Plasma Cells in vitro through IL-6.2018
- Author(s)
  Atsuko Kayaba, Ari Itoh-Nakadai, Kunimichi Niibe, Matsuyuki Shirota, Ryo Funayama, Akiko Sugahara-Tobinai, Yi Li Wong, Masanori Inui, Keiko Nakayama, and Toshiyuki Takai.
- Journal Title
  
  Int Immunol.
  
  Volume: in press Pages: 241-253
- DOI
  10.1093/intimm/dxy018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19539, KAKENHI-PROJECT-17K15714, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-15KK0328, KAKENHI-PROJECT-17K08874, KAKENHI-PROJECT-16K20480
[Journal Article] Efficacy and safety of gemcitabine plus docetaxel in Japanese patients with unresectable or recurrent bone and soft tissue sarcoma: Results from a single-institutional analysis2017
- Author(s)
  Takahashi M, Komine K, Imai H, Okada Y, Saijo K, Takahashi M, Shirota H, Ohori H, Takahashi S, Chiba N, Mori T, Shimodaira H, Ishioka C.
- Journal Title
  
  PLoS One
  
  Volume: 12(5)
- DOI
  10.1371/journal.pone.0176972
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07106, KAKENHI-PROJECT-16H04690, KAKENHI-PROJECT-15K08962, KAKENHI-PROJECT-16K10488
[Journal Article] Lack of Transcription Triggers H3K27me3 Accumulation in the Gene Body.2016
- Author(s)
  Hosogane, M., Funayama, R., Shirota, M., Nakayama, K.
- Journal Title
  
  Cell Rep.
  
  Volume: 16 Pages: 696-706
- DOI
  10.1016/j.celrep.2016.06.034
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26293059, KAKENHI-PROJECT-15K18453
[Presentation] Comprehensive and Up-to-date Annotation of Nonsynonymous Single Nucleotide Variants of Human Genome with Protein Structure Information2020
- Author(s)
  Matsuyuki Shirota
- Organizer
  第20回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] マイクロエクソンの発現と調節に関する情報解析2019
- Author(s)
  城田松之
- Organizer
  次世代脳冬のシンポジウム
- Data Source
  KAKENHI-PUBLICLY-19H04891
[Presentation] RNA-seqデータを用いた選択的マイクロエクソンの構造・機能解析2019
- Author(s)
  城田松之
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PUBLICLY-19H04891
[Presentation] Analysis on nonsynonymous variations with possible structural and functional impact on loss-of-function intolerant proteins2019
- Author(s)
  Matsuyuki Shirota
- Organizer
  ISMB 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] Development of a genome annotation system based on protein three-dimensional structures2018
- Author(s)
  Matsuyuki Shirota
- Organizer
  ISMB2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] 蛋白質立体構造と機能に影響しうるゲノムバリアントの選択と解析2018
- Author(s)
  城田松之
- Organizer
  日本生物物理学会第56回年会
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] 蛋白質立体構造を用いたゲノムバリアントのアノテーション法の開発と日本人集団バリアントへの応用2018
- Author(s)
  城田松之
- Organizer
  第41回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] Development of genome variant annotation system with protein 3D structures and applications to variants in Japanese population2018
- Author(s)
  Matsuyuki Shirota
- Organizer
  第 7 回生命医薬情報学連合大会
- Data Source
  KAKENHI-PROJECT-18K06194
[Presentation] Regulation and structure-function relationship of alternative microexons in proteins2017
- Author(s)
  Matsuyuki Shirota
- Organizer
  第17回日本蛋白質科学会年会
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] Structural and functional analysis of alternative microexons of proteins observed in RNA-seq studies.2017
- Author(s)
  Matsuyuki Shirota
- Organizer
  ISMB/ECCB2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] Population genomics and structural bioinformatics: an analysis of missense variants in a Japanese cohort based on protein structures2017
- Author(s)
  Matsuyuki Shirota
- Organizer
  2nd Karolinska-Tohoku Joint Symposium on Medical Sciences
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] NGSで見つかる選択的マイクロエクソンとタンパク質構造・機能への影響2017
- Author(s)
  城田松之
- Organizer
  NGS現場の回第五回研究会
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] Annotation of missense genomic variations based on various protein 3D structures2017
- Author(s)
  Matsuyuki Shirota
- Organizer
  日本生物物理学会第55回年会
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] Cold adaptation of organisms and the evolution of protein sequences2016
- Author(s)
  城田松之
- Organizer
  第54回日本生物物理学会
- Place of Presentation
  つくば国際会議場（つくば市）
- Year and Date
  2016-11-25
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] Discrepancies between human reference genome, mRNA and protein sequences and their relation to single nucleotide variants2016
- Author(s)
  Matsuyuki Shirota and Kengo Kinoshita
- Organizer
  第５回生命医薬情報学連合大会
- Place of Presentation
  東京国際交流館プラザ平成（江東区）
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K16142
[Presentation] pdbBAM: a comprehensive mapping of Protein Data Bank proteins on the human genome.2015
- Author(s)
  Matsuyuki Shirota
- Organizer
  ISMB/ECCB2015
- Place of Presentation
  Dublin, Ireland
- Year and Date
  2015-07-14
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26730148
[Presentation] 埋もれた極性残基の進化的保存．2015
- Author(s)
  城田松之
- Organizer
  第53回日本生物物理学会
- Place of Presentation
  金沢市，金沢大学角間キャンパス
- Year and Date
  2015-09-14
- Data Source
  KAKENHI-PROJECT-26730148
[Presentation] 蛋白質における埋もれた極性残基の進化的保存2015
- Author(s)
  城田松之
- Organizer
  CPS研究会2015
- Place of Presentation
  雄琴市，湯の宿木もれび
- Year and Date
  2015-09-29
- Data Source
  KAKENHI-PROJECT-26730148
[Presentation] 蛋白質における埋もれた極性残基の構造と置換パターンの網羅的解析2014
- Author(s)
  Matsuyuki Shirota, Kengo Kinoshita
- Organizer
  第52回日本生物物理学会
- Place of Presentation
  札幌コンベンションセンター（札幌市）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-26730148

1. NAKAYAMA Keiko (60294972)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
2. FUNAYAMA Ryo (20452295)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. CHIBA Natsuko (50361192)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
4. 吉野優樹 (60755700)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. HOSOGANE Masaki (30734347)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
6. 渡部剛 (70451573)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. 渡邊利雄 (60201208)

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8. 中川直 (30707013)

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9. 大塚慧 (20772437)

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10. TAKAHASHI Masanobu

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11. TAKAHASHI Hidekazu

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# of Collaborated Products: 1 results
12. MORI Takahiro

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13. NIIHORI Tetsuya

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# of Collaborated Products: 2 results
14. INUI Masanori

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# of Collaborated Products: 1 results
15. OKADA Satoshi

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16. 塚口裕康

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17. 石井直人

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18. 宗孝紀

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19. 奥山祐子

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20. 菊池敦生

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21. 呉繁夫

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22. 飯島一誠

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23. 仲川清隆

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24. 鈴木貴

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25. 内藤剛

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26. 唐澤秀明

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27. 山村明寛

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28. 城田英和

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29. 渡辺利雄

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30. 要匡

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31. 酒井康成

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# of Collaborated Products: 1 results
32. 松本浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
33. 松本直通

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
34. 高井俊行

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
35. 伊藤亜里

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
36. 新部邦透

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
37. 遠渡沙緒理

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
38. 青木洋子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
39. 阿部太紀

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
40. 井上晋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIROTA Matsuyuki 城田 松之

Shirota Matsuyuki 城田 松之

Research Projects

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中心体異常とDNA損傷によるゲノム不安定性を標的とする新しいがん治療法の開発

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Prediction and validation of regulatory variants based on DNA/RNA-protein complex structuresPrincipal Investigator

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Multi-layer informatics analysis on brain and personality focused on microexonsPrincipal Investigator

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Development of Targeting therapy for centrosome dysregulation in cancer

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Development of information system for functional annotation of genomic sequence alterations by using protein 3D structuresPrincipal Investigator

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Elucidation of the signaling pathways that induce gene amplification

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Elucidation of the mechanism of transcription elongation rate control by histone code

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Elucidation of regulatory mechanism to maintain genome stability by novel BRCA1-interacting molecules and development of cancer therapy

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Verification of genomic diversity required for tumorigenesis

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Refinement of protein structure prediction by using simulation and database analysesPrincipal Investigator

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Genome wide analysis of epigenetic regulation of enhancer activity via H3K27 modifications

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Development of a database of buried polar residues in protein structuresPrincipal Investigator

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[Journal Article] BRCA1/ATF1-mediated transactivation is involved in resistance to PARP inhibitors and cisplatin2021

Author(s)

Journal Title

SHIROTA Matsuyuki 城田松之

Shirota Matsuyuki 城田松之