Kuwahara Makoto 桑原誠

Researcher Number	00568214
Affiliation (Current)	2025: 愛媛大学, 医学系研究科, 講師
Affiliation (based on the past Project Information) *help	2019 – 2024: 愛媛大学, 医学系研究科, 講師 2017 – 2018: 愛媛大学, 医学系研究科, 助教 2016 – 2017: 愛媛大学, 医学部附属病院, 助教(病院教員) 2016: 愛媛大学, 大学院医学系研究科, 助教 2015: 愛媛大学, 医学部附属病院, その他 … More 2015: 愛媛大学, 医学部附属病院, 助教(特定教員) 2014: 愛媛大学, 医学部附属病院, 助教(病院教員) 2013: 愛媛大学, 医学部附属病院, 助教 Less
Review Section/Research Field	Principal Investigator Basic Section 53030:Respiratory medicine-related / Immunology / Basic Section 54020:Connective tissue disease and allergy-related Except Principal Investigator Pathological medical chemistry / Immunology
Keywords	Principal Investigator Bach2 / Th2 / T細胞自然免疫応答 / アレルギー性気道炎症 / 気道炎症 / T細胞 / IL-33R+ Th2 / 肺胞蛋白症 / IL-33R / IL-7R … More / IL-7 receptor / 脂質代謝 / Tpath2 / 抗原非依存性Th2免疫応答 / IL-7 / 獲得免疫 / 活性化 T 細胞運命決定 / H3K27me2/3 / a-ケトグルタル酸 / T 細胞老化 / Utx / グルタミン代謝 / T細胞運命決定 / 免疫老化 … More Except Principal Investigator 炎症 / 免疫 / Th2 / 免疫学 / アレルギー / Akt / mTORC1 / アレルギー炎症 / Th2型気道炎症 / Batf / Bach2 / アレルギー・ぜんそく / サイトカイン / エピゲノム / ヘルパーT細胞 / グルタミン代謝 Less

Bach2 による T 細胞自然免疫応答調節を介した肺恒常性維持機構の解明Principal Investigator
- Principal Investigator
  
  桑原誠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Ehime University
Role of T cell on lung homeostasis and dieseasesPrincipal Investigator
- Principal Investigator
  
  Kuwahara Makoto
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53030:Respiratory medicine-related
- Research Institution
  Ehime University
Bach2 regulates antigen-independent Th2 responses and chronic type2 airway inflammation.Principal Investigator
- Principal Investigator
  
  Kuwahara Makoto
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Ehime University
Investigations of the role of glutamine metabolism in the T cell fate determinationPrincipal Investigator
- Principal Investigator
  
  Kuwahara Makoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Ehime University
Determination of helper T cell fate by amino acid metabolism
- Principal Investigator
  
  Yamashita Masakatsu
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Immunology
- Research Institution
  Ehime University
Analysis of Bach2-mediated regulation of the chronic allergic inflammation
- Principal Investigator
  
  Yamashita Masakatsu
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Ehime University
An investigation of the role of the transcription repressor Bach2 in CD4 T cell-mediated immune homeostasisPrincipal Investigator
- Principal Investigator
  
  Kuwahara Makoto
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Immunology
- Research Institution
  Ehime University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 Other

All Journal Article Presentation

[Journal Article] The histone demethylase Utx controls <scp>CD8</scp> <sup>+</sup> T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function2023
- Author(s)
  Noda Haruna、Suzuki Junpei、Matsuoka Yuko、Matsumoto Akira、Kuwahara Makoto、Kamei Yoshiaki、Takada Yasutsugu、Yamashita Masakatsu
- Journal Title
  
  Cancer Science
  
  Volume: - Issue: 7 Pages: 2787-2797
- DOI
  10.1111/cas.15814
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08205, KAKENHI-PROJECT-20H03504
[Journal Article] The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice2023
- Author(s)
  Michiko Okamoto, Miyuki Omori-Miyake, Makoto Kuwahara, Masataka Okabe, Mariko Eguchi, Masakatsu Yamashita
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: － Issue: 10 Pages: 1973-1982.e5
- DOI
  10.1016/j.jid.2023.03.1667
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K08433, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-23K07270, KAKENHI-PROJECT-21K08205
[Journal Article] Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response2022
- Author(s)
  Konishi Amane、Suzuki Junpei、Kuwahara Makoto、Matsumoto Akira、Nomura Shunsuke、Soga Tomoyoshi、Yorozuya Toshihiro、Yamashita Masakatsu
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 588 Pages: 34-40
- DOI
  10.1016/j.bbrc.2021.12.050
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-21K08205
[Journal Article] The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis2021
- Author(s)
  Inoue Takashi、Omori-Miyake Miyuki、Maruyama Saho、Okabe Masataka、Kuwahara Makoto、Honda Hiroaki、Miura Hiromasa、Yamashita Masakatsu
- Journal Title
  
  The Journal of Immunology
  
  Volume: 207 Issue: 9 Pages: 2223-2234
- DOI
  10.4049/jimmunol.2001160
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K22546, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-19H03693, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-21K08205
[Journal Article] Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation.2020
- Author(s)
  Yagi Y, Kuwahara M, Suzuki J, Imai Y and Yamashita M.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 530 Issue: 2 Pages: 355-361
- DOI
  10.1016/j.bbrc.2020.08.009
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-18K08083, KAKENHI-PROJECT-18K08409
[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020
- Author(s)
  Toriyama K, Kuwahara M, Kondoh H, Mikawa T, Takemori N, Konishi A., Yorozuya T, Yamada T, Soga T., Shiraishi A, and Yamashita M.
- Journal Title
  
  Communications Biology
  
  Volume: 3 Issue: 1 Pages: 1-13
- DOI
  10.1038/s42003-020-01122-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07680, KAKENHI-ORGANIZER-17H06391, KAKENHI-PUBLICLY-20H04948, KAKENHI-PROJECT-20H03504, KAKENHI-PROJECT-18K08409, KAKENHI-PROJECT-19K07887, KAKENHI-PROJECT-20K20658
[Journal Article] Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro2019
- Author(s)
  Nomura Shunsuke、Takahashi Hirotaka、Suzuki Junpei、Kuwahara Makoto、Yamashita Masakatsu、Sawasaki Tatsuya
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 17335-17335
- DOI
  10.1038/s41598-019-53856-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08409, KAKENHI-PLANNED-16H06579, KAKENHI-PUBLICLY-18H05036, KAKENHI-PUBLICLY-19H05292, KAKENHI-PROJECT-19H03218, KAKENHI-PROJECT-18J12730, KAKENHI-PROJECT-17K07261
[Journal Article] BATF-Interacting Proteins Dictate Specificity in Th Subset Activity2019
- Author(s)
  Fu Yongyao、Koh Byunghee、Kuwahara Makoto、Ulrich Benjamin J.、Kharwadkar Rakshin、Yamashita Masakatsu、Kaplan Mark H.
- Journal Title
  
  The Journal of Immunology
  
  Volume: 203 Issue: 7 Pages: 1989-1998
- DOI
  10.4049/jimmunol.1900128
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-18H05036
[Journal Article] The critical role of Bach2 in regulating type-2 chronic airway inflammation2018
- Author(s)
  Yamashita Masakatsu、Kuwahara Makoto
- Journal Title
  
  International Immunology
  
  Volume: - Issue: 9 Pages: 397-402
- DOI
  10.1093/intimm/dxy020
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K19158, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-18H05036
[Journal Article] Reinforce the antitumor activity of CD8+ T cells via glutamine restriction2018
- Author(s)
  Nabe Shogo、Yamada Takeshi、Suzuki Junpei、Toriyama Koji、Yasuoka Toshiaki、Kuwahara Makoto、Shiraishi Atsushi、Takenaka Katsuto、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 12 Pages: 3737-3750
- DOI
  10.1111/cas.13827
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-17H05794, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-18H02840, KAKENHI-PROJECT-17K15728, KAKENHI-PROJECT-17K16853, KAKENHI-PROJECT-18H02839
[Journal Article] The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation2018
- Author(s)
  Suzuki Junpei、Yamada Takeshi、Inoue Kazuki、Nabe Shogo、Kuwahara Makoto、Takemori Nobuaki、Takemori Ayako、Matsuda Seiji、Kanoh Makoto、Imai Yuuki、Yasukawa Masaki、Yamashita Masakatsu
- Journal Title
  
  Nature Communications
  
  Volume: 9 Issue: 1 Pages: 1-12
- DOI
  10.1038/s41467-018-05854-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K08887, KAKENHI-PROJECT-18K08409, KAKENHI-PUBLICLY-17H05794, KAKENHI-ORGANIZER-17H06391, KAKENHI-PROJECT-17H04086, KAKENHI-PROJECT-17K15728, KAKENHI-PROJECT-18H02839
[Journal Article] Inflammatory responses induce an identity crisis of alveolar macrophages, leading to pulmonary alveolar proteinosis.2017
- Author(s)
  Ebina-Shibuya R, Matsumoto M, Kuwahara M, Jang KJ, Sugai M, Ito Y, Funayama R, Nakayama K, Sato Y, Ishii N, Okamura Y, Kinoshita K, Kometani K, Kurosaki T, Muto A, Ichinose M, Yamashita M, Igarashi K.
- Journal Title
  
  The Journal of biological chemistry
  
  Volume: 292 Issue: 44 Pages: 18098-18112
- DOI
  10.1074/jbc.m117.808535
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07108, KAKENHI-PROJECT-16K08572, KAKENHI-PROJECT-16K15232, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H02506, KAKENHI-PROJECT-15H04742, KAKENHI-PROJECT-16H05138, KAKENHI-PROJECT-16H05307, KAKENHI-PROJECT-17H04035, KAKENHI-PROJECT-16H06640, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K15508, KAKENHI-PROJECT-16K19158
[Journal Article] Bach2-Batf interactions control Th2-type immune response by regulating the IL-4 amplification loop.2016
- Author(s)
  Kuwahara M, Ise W, Ochi M, Suzuki J, Kometani K, Maruyama S, Izumoto M, Matsumoto A, Takemori N, Takemori A, Shinoda K, Nakayama T, Ohara O, Yasukawa M, Sawasaki T, Kurosaki T, Yamashita M.
- Journal Title
  
  Nature Communications
  
  Volume: 7 Issue: 1 Pages: 12596-12596
- DOI
  10.1038/ncomms12596
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-16H06579, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26221306, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-15K15155, KAKENHI-PROJECT-15K19133, KAKENHI-PROJECT-16K15289, KAKENHI-PROJECT-16K19158
[Journal Article] Gfi1, a transcriptional repressor, inhibits the induction of the T helper type 1 programme in activated CD4 T cells2016
- Author(s)
  Junpei Suzuki, Saho Maruyama, Hidekazu Tamauchi, Makoto Kuwahara, Mika Horiuchi, Masumi Mizuki, Mizuki Ochi, Tatsuya Sawasaki, Jinfang Zhu, Masaki Yasukawa, Masakatsu Yamashita
- Journal Title
  
  Immunology
  
  Volume: 147 Issue: 4 Pages: 476-487
- DOI
  10.1111/imm.12580
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462851, KAKENHI-PROJECT-25860376, KAKENHI-PROJECT-15H04858, KAKENHI-PROJECT-16H04729, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-15K19133
[Journal Article] Menin Plays a Critical Role in the Regulation of the Antigen-Specific CD8+ T Cell Response upon Listeria Infection2016
- Author(s)
  Yamada T, Kanoh M, Nabe S, Yasuoka T, Suzuki J, Matsumoto A, Kuwahara M, Maruyama S, Fujimoto T, Sakisuka R, Yasukawa M, and Yamashita M.
- Journal Title
  
  Journal of Immunology
  
  Volume: 197 Issue: 10 Pages: 4079-4089
- DOI
  10.4049/jimmunol.1502295
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460579, KAKENHI-PROJECT-15K15155, KAKENHI-PROJECT-15K19133, KAKENHI-PROJECT-15K20149
[Journal Article] A novel function of interferon regulatory factor-1: inhibition of Th2 cells by down-regulating the Il4 gene during Listeria infection2015
- Author(s)
  Maruyama Saho, Kanoh Makoto, Matsumoto Akira, Kuwahara Makoto, Yamashita Masakatsu, Asano Yoshihiro
- Journal Title
  
  International Immunology
  
  Volume: 27 Issue: 3 Pages: 143-152
- DOI
  10.1093/intimm/dxu092
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860376
[Journal Article] The Menin-Bach2 axis is critical for regulating CD4 T cell senescence and cytokine homeostasis2014
- Author(s)
  Kuwahara, M., Suzuki, J., Tofukuji, S., Yamada, T., Kanoh, M., Matsumoto, A., Maruyama, S., Kometani, K., Kurosaki, T., Ohara, O., Nakayama, T., Yamashita, M
- Journal Title
  
  Nature Comm
  
  Volume: 5 Issue: 1 Pages: 3555-3555
- DOI
  10.1038/ncomms4555
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21229007, KAKENHI-PROJECT-23390075, KAKENHI-PROJECT-24659475, KAKENHI-PUBLICLY-25118718, KAKENHI-PROJECT-25670232, KAKENHI-PROJECT-25860376, KAKENHI-PROJECT-26221305, KAKENHI-PROJECT-26293069, KAKENHI-PROJECT-26460579
[Presentation] Bach2 controls IL-33-dependent innate Th2 cell response through regulation of Jmjd3 (Kdm6b), a histoneH3K27me2/3 demethylase2023
- Author(s)
  Makoto Kuwahara, Junpei Suzuki, Akira Matsumoto, Yukihiro Nakamura, Hiroaki Honda, Naohiko Hamaguchi, Osamu Yamaguchi, Masakatsu Yamashita
- Organizer
  第72回日本アレルギー学会学術大
- Data Source
  KAKENHI-PROJECT-21K08205
[Presentation] A thioamide-related small compound SH-2251, an inhibitor of transcriptional repressor Gfi1 expression, inhibits IL-7/IL-33-dependent innate Th2 response and Th2-type chronic lung inflammation2022
- Author(s)
  Kuwahara Makoto, Suzuki Junpei, Maruyama Saho, Nakamura Yukihiro, Hamaguchi Naohiko, Yamaguchi Osamu, Yamashita Masakatsu
- Organizer
  第71回日本アレルギー学会学術大
- Data Source
  KAKENHI-PROJECT-21K08205
[Presentation] Transcriptional repressor Gfi1 induces IL-7/IL-33-dependent innate-like Th2 responses by activating cellular metabolism2021
- Author(s)
  桑原誠、山下政克
- Organizer
  第70回日本アレルギー学会
- Data Source
  KAKENHI-PROJECT-21K08205
[Presentation] The critical role of Bach2 in preventing antigen-independent innate-type Th2 response2019
- Author(s)
  Makoto Kuwahara
- Organizer
  第48回日本免疫学会学術集会
- Data Source
  KAKENHI-PROJECT-18K08409
[Presentation] The transcriptional repressor Bach2 controls antigenindependent Th2 cell response2019
- Author(s)
  Makoto Kuwahara
- Organizer
  14th World Congress on Inflammation Sydney 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08409
[Presentation] Transcriptional repressor Bach2 controls antigen-independent Th2 responses by regulating glycolysis2019
- Author(s)
  Makoto Kuwahara
- Organizer
  第68回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08409
[Presentation] The transcriptional repressor Bach2 controls pathogenic Th2 differentiation via two distinct pathway2018
- Author(s)
  Makoto Kuwahara, Maya Izumoto, Masakatsu Yamashita
- Organizer
  第６７回日本アレルギー学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08409
[Presentation] The critical role of Bach2 in regulating antigen-independent Th2 responses.2018
- Author(s)
  Makoto Kuwahara, Tomohiro Kurosaki, Masakatsu Yamashita
- Organizer
  第47回日本免疫学会学術大会
- Data Source
  KAKENHI-PROJECT-18K08409
[Presentation] Bach2-Batf interactions control Th2-type airway chronic inflammation.2017
- Author(s)
  Kuwahara Makoto, Yamashita Masakatsu
- Organizer
  The 19th Takeda Science Foundation Symposium on Bioscience Chronic Inflammation -Initiation, Progression and Regulation-
- Data Source
  KAKENHI-PROJECT-16K19158
[Presentation] The transcriptional repressor Bach2 regulates differentiation of pathogenic Th2 cells.2017
- Author(s)
  Kuwahara Makoto, Yamashita Masakatsu
- Organizer
  第 46 回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-16K19158
[Presentation] The transcriptional repressor Bach2 controls Th2-type immune response via interaction with Batf.2017
- Author(s)
  Kuwahara Makoto, Sawasaki Tatsuya, Yamashita Masakatsu
- Organizer
  The 5th Annual Meeting of the International Cytokine and Interferon Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19158
[Presentation] TCR-mediated activation of glutamine metabolism play a critical role in regulating Th2 cell differentiation2016
- Author(s)
  Makoto Kuwahara, Kazuki Inoue, Yuuki Imai, Masakatsu Yamashita
- Organizer
  第 65 回日本アレルギー学会学術大会
- Place of Presentation
  東京
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-16K19158
[Presentation] 腫瘍抑制因子 Menin による T 細胞老化制御2016
- Author(s)
  桑原誠、鈴木淳平、山田武司、山下政克
- Organizer
  第 16 回日本抗加齢医学会総会
- Place of Presentation
  横浜
- Year and Date
  2016-06-11
- Invited
- Data Source
  KAKENHI-PROJECT-16K19158
[Presentation] TCR-mediated activation of glutamine metabolism plays a critical role in regulating Th2 cell differentiation.2016
- Author(s)
  Kuwahara M., Inoue K., Imai Y., Yamashita M.
- Organizer
  第65回日本アレルギー学会学術大会
- Place of Presentation
  東京国際フォーラム
- Year and Date
  2016-06-17
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2 interacts with Batf family transcription factors and inhibits Th2 cell differentiation.2016
- Author(s)
  Ochi M., Kuwahara M., Suzuki J., Matsumoto A., Kurosaki T., Yasukawa M., Sawasaki T., Yamashita M.
- Organizer
  International Conference of Immunology 2016
- Place of Presentation
  メルボルン、オーストラリア
- Year and Date
  2016-08-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Bach2 controls the thpe-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2 inhibits Th2-type immune responses by regulating glutamine metabolism2015
- Author(s)
  Masakatsu Ymasahita, Makoto Kuwahara
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪 (東京都港区)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 腫瘍抑制因子Meninは代謝調節を介してCD8 T細胞老化を制御する2015
- Author(s)
  鈴木淳平、桑原誠、山田武司、安川正貴、山下政克
- Organizer
  第３回がんと代謝研究会
- Place of Presentation
  石川県立音楽堂 (石川県金沢市)
- Year and Date
  2015-07-16
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2 controls the thpe-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Bach2 and Blimp1 cooperatively regulate Il1rl1 expression in CD4 T cells2015
- Author(s)
  IZUMOTO Maya, KUWAHARA Makoto, OCHI Mizuki, MATSUMOTO Akira, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 腫瘍抑制因子 Menin は T 細胞の老化を制御する(Crucial role of Menin in the regulation of T cell immunosenescence)2015
- Author(s)
  桑原誠、鈴木淳平、山下政克
- Organizer
  第３８回日本分子生物学会年会・第８８回日本生化学会大会・合同大会
- Place of Presentation
  神戸ポートアイランド（兵庫県、神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 controls the type-2 immune response by regulating glutamine metabolism2015
- Author(s)
  KUWAHARA Makoto, OCHI Mizuki, IZUMOTO Maya, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第４４回日本免疫学会学術集会
- Place of Presentation
  札幌コンベンションセンター（北海道、札幌市）
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 interacts with Batf family transcription factors and inhibits Th2 cell differentiation2015
- Author(s)
  OCHI Mizuki, KUWAHARA makoto, MATSUMOTO Akira, KUROSAKI Tomohiro, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集会
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Menin plays an critical role in the survival of antigen-specific activated CD8+ T cells2015
- Author(s)
  YAMADA Takeshi, KANOH Makoto, MATSUMOTO Akira, YASUOKA Toshiaki, SUZUKI Junpei, MARUYAMA Saho, KUWAHARA Makoto, YASUKAWA Masaki, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Th2細胞分化には細胞内グルタミン代謝が必要である2015
- Author(s)
  塩入幹汰、桑原誠、山下政克
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪 (東京都港区)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Th2細胞分化には細胞内グルタミン代謝が必要である2015
- Author(s)
  塩入幹汰、桑原誠、山下政克
- Organizer
  第64回日本アレルギー学会学術大会
- Place of Presentation
  グランドプリンスホテル新高輪 (東京都港区)
- Year and Date
  2015-05-26
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] A tumor suppressor Menin controls CD8 T cell senescence by regulating energy metabolism2015
- Author(s)
  SUZUKI Junpei, KUWAHARA Makoto, MARUYAMA Saho, YAMADA Takeshi, YASUOKA Toshiaki, YASUKAWA Masaki, YAMASHITA Masakatsu
- Organizer
  第44回日本免疫学会総会・学術集
- Place of Presentation
  札幌コンベンションセンター (北海道札幌市)
- Year and Date
  2015-11-18
- Data Source
  KAKENHI-PROJECT-15K15155
[Presentation] Bach2-Blimp1 axis plays an important role in the regulation of allergic airway inflammation
- Author(s)
  Izumoto M, Kuwahara M, Kiyoi T, Shinoda K, Nakayama T, Kurosaki T and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 転写調節因子Bach2によるヘルパーT細胞サブセット分子とアレルギー性気道炎症の制御
- Author(s)
  桑原誠、山下政克
- Organizer
  第24回 Kyoto T Cell Conference
- Place of Presentation
  京都平安ホテル
- Year and Date
  2014-05-16 – 2014-05-17
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] Bach2 controls Th2 cell-mediated immune responses through regulation of glutaminolysis
- Author(s)
  Kuwahara M, Ochi M, Kiyoi T, Kurosaki T and Yamashita M.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都国際会議場
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-26293069
[Presentation] 腫瘍抑制因子MeninによるCD4T細胞機能の制御
- Author(s)
  桑原　誠、山下　政克
- Organizer
  第12回　四国免疫フォーラム
- Place of Presentation
  徳島文理大学香川キャンパス、香川
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Crucial role of Menin in the regulation of CD4 T cell senescence
- Author(s)
  Makoto Kuwahara, Toshinori Nakayama, Masakatsu Yamashita
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  MiCo-Milano Congressi, Milan, Italy
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Bach2 controls Th2 cell-mediated immune responses through regulation of glutaminolysis
- Author(s)
  Kuwahara Makoto, Ochi Mizuki, Kiyoi Takeshi, Kurosaki Tomohiro, Yamashita Masakatsu
- Organizer
  日本免疫学会
- Place of Presentation
  国立京都国際会館（京都）
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-25860376
[Presentation] Menin inhibits transcriptional programs that promote CD4 T cell senescence and Th1/Th2 differentiation
- Author(s)
  Makoto Kuwahara, Takeshi Yamada, Toshinori Nakayama, Masakatsu Yamashita
- Organizer
  第42回　日本免疫学会学術集会
- Place of Presentation
  幕張メッセ、千葉
- Data Source
  KAKENHI-PROJECT-25860376

1. Yamashita Masakatsu (00311605)

# of Collaborated Projects: 4 results

# of Collaborated Products: 28 results
2. TAMAUCHI Hidekazu (60188414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
3. SUZUKI Junpei

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. OMORI Miyuki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. MATSUMOTO Mitsuyo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. SATO masaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. IGARASHI kazuhiko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 黒崎知博

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山田武司

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
10. 澤崎達也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 本田善一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 本田浩章

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwahara Makoto 桑原 誠

Research Projects

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Co-Researchers

Bach2 による T 細胞自然免疫応答調節を介した肺恒常性維持機構の解明Principal Investigator

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Role of T cell on lung homeostasis and dieseasesPrincipal Investigator

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Bach2 regulates antigen-independent Th2 responses and chronic type2 airway inflammation.Principal Investigator

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Investigations of the role of glutamine metabolism in the T cell fate determinationPrincipal Investigator

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Determination of helper T cell fate by amino acid metabolism

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Analysis of Bach2-mediated regulation of the chronic allergic inflammation

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An investigation of the role of the transcription repressor Bach2 in CD4 T cell-mediated immune homeostasisPrincipal Investigator

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[Journal Article] The histone demethylase Utx controls <scp>CD8</scp> <sup>+</sup> T‐cell‐dependent antitumor immunity via epigenetic regulation of the effector function2023

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[Journal Article] The Inhibition of Glycolysis in T Cells by a Jak Inhibitor Ameliorates the Pathogenesis of Allergic Contact Dermatitis in Mice2023

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[Journal Article] Glucocorticoid imprints a low glucose metabolism onto CD8 T cells and induces the persistent suppression of the immune response2022

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[Journal Article] The Loss of H3K27 Histone Demethylase Utx in T Cells Aggravates Allergic Contact Dermatitis2021

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[Journal Article] Glycolysis and subsequent mevalonate biosynthesis play an important role in Th2 cell differentiation.2020

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[Journal Article] T cell-specific deletion of Pgam1 reveals a critical role for glycolysis in T cell responses.2020

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[Journal Article] Pyrrothiogatain acts as an inhibitor of GATA family proteins and inhibits Th2 cell differentiation in vitro2019

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Kuwahara Makoto 桑原誠