Mizoguchi Izuru 溝口出

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MIZOGUCHI Izuru 溝口出

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Researcher Number	00569527
Affiliation (Current)	2025: 東京医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2016 – 2024: 東京医科大学, 医学部, 講師 2012 – 2015: 東京医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Basic Section 63030:Chemical substance influence on environment-related / Biological pharmacy Except Principal Investigator Basic Section 90110:Biomedical engineering-related / Basic Section 43030:Functional biochemistry-related / Orthopaedic surgery
Keywords	Principal Investigator 呼吸器感作性 / 動物実験代替法 / IL-23R / 腸炎 / EBI3 / IL-4 / Th2細胞活性化 / 呼吸器アレルギー誘発性評価 / DC前駆細胞株 / T細胞クローン … More / 単球細胞株 / Th2細胞株 / Th2細胞 / ヒト単球細胞株 / in vitro細胞共培養系 / アレルギー感作性 / 樹状細胞 / 3次元共培養系 / 化学物質 / アレルギー / 感作性 / Th2反応 / 皮膚感作性 / 感作性評価法 / カルネキシン / IL-23Ra / Colitis / オートファジー / IL-23レセプター / IL-27 … More Except Principal Investigator アジュバント / ワクチン / アジュバントフリー / 抗腫瘍ワクチン / 無針注射器 / MHCクラスI / オートファジー / Sequestosome 1 / IL-23Rα / gp130 / 蛋白質発現 / 分子シャペロン / カルネキシン / EBI3 / 移植・再生医療 / 再生医学 / IL-35 / 免疫調節 / IL-27 / 間葉系幹細胞 Less

Th2細胞活性化を指標にした呼吸器アレルギー誘発性評価の動物実験代替法の開発Principal Investigator
- Principal Investigator
  
  溝口出
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo Medical University
新規無針注入器によるDNA・蛋白質の皮内投与によるワクチン効果と遺伝子治療増強
- Principal Investigator
  
  善本隆之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  Tokyo Medical University
Development of a novel coculture system using human monocyte cell line-derived immature dendritic cells and T cells for evaluation of allergic sensitizing potentialPrincipal Investigator
- Principal Investigator
  
  Mizoguchi Izuru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo Medical University
A novel mechanism whereby EBI3, one of IL-27 cytokine subunits, augments target protein expression under inflammatory conditions
- Principal Investigator
  
  Yoshimoto Takayuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 43030:Functional biochemistry-related
- Research Institution
  Tokyo Medical University
Development of a novel alternative to animal testing for the evaluation of respiratory allergic sensitizing potential of chemicalsPrincipal Investigator
- Principal Investigator
  
  Mizoguchi Izuru
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 63030:Chemical substance influence on environment-related
- Research Institution
  Tokyo Medical University
Therapeutic effect of mesenchymal stem cells by anti-inflammatory cytokinesIL-27 and IL-35
- Principal Investigator
  
  OWAKI Toshiyuki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Kyushu University
  Tokyo Medical University
A novel role for EBI3, a common subunit of IL-27 and IL-35, as a intracellular molecule in the augmentation of IL-23Ra protein expressionPrincipal Investigator
- Principal Investigator
  
  Mizoguchi Izuru
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical University
Regulation of immune responses by IL-23 p19, IL-27 EBI3 or their new heterodimerPrincipal Investigator
- Principal Investigator
  
  MIZOGUCHI Izuru
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  Tokyo Medical University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] Potent antitumor effects of the conditioned medium of bone marrow-derived mesenchymal stem cells via IGFBP-4.2023
- Author(s)
  Furusaka Y, Inoue S, Mizoguchi I, Hasegawa H, Katahira Y, Watanabe A, Sakamoto E, Sekine A, Miyakawa S, Umezu T, Owaki T, Yoneto T, Yoshimoto T.
- Journal Title
  
  Cancer Sci.
  
  Volume: in press Issue: 6 Pages: 2499-2514
- DOI
  10.1111/cas.15789
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07504, KAKENHI-PROJECT-22K08018, KAKENHI-PROJECT-22K15696, KAKENHI-PROJECT-22K16291, KAKENHI-PROJECT-22K08722, KAKENHI-PROJECT-22K12772, KAKENHI-PROJECT-23K09087, KAKENHI-PROJECT-21K07133, KAKENHI-PROJECT-21K09779, KAKENHI-PROJECT-21K12256
[Journal Article] A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant2023
- Author(s)
  Jukito Sonoda,Izuru Mizoguchi,Shinya Inoue,Aruma Watanabe,Ami Sekine,Miu Yamagishi,Satomi Miyakawa,Natsuki Yamaguchi,Eri Horio,Yasuhiro Katahira,Hideaki Hasegawa,Takashi Hasegawa,Kunihiko Yamashita and Takayuki Yoshimoto
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 24 Issue: 10 Pages: 9094-9094
- DOI
  10.3390/ijms24109094
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K15696, KAKENHI-PROJECT-22K16291, KAKENHI-PROJECT-22K07504, KAKENHI-PROJECT-22K12772, KAKENHI-PROJECT-23K09087, KAKENHI-PROJECT-21K12256, KAKENHI-PROJECT-22K08018
[Journal Article] Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases via Haptenation.2023
- Author(s)
  Sakamoto E, Katahira Y, Watanabe A, Furusaka Y, Sekine A, Yamagishi M, Sonoda J, Miyakawa S, Inoue S, Hasegawa H, Yo K, Yamaji F, Toyoda T, Mizoguchi I, Yoshimoto T.
- Journal Title
  
  Biology (Basel)
  
  Volume: 12(1) Issue: 1 Pages: 123-123
- DOI
  10.3390/biology12010123
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K12256, KAKENHI-PROJECT-22K07504, KAKENHI-PROJECT-22K08018, KAKENHI-PROJECT-22K15696, KAKENHI-PROJECT-22K16291, KAKENHI-PROJECT-23K09087
[Journal Article] Protective effects of conditioned media of immortalized stem cells from human exfoliated deciduous teeth on pressure ulcer formation.2023
- Author(s)
  Katahira Y, Murakami F, Inoue S, Miyakawa S, Sakamoto E, Furusaka Y, Watanabe A, Sekine A, Kuroda M, Hasegawa H, Mizoguchi I, Yoshimoto T.
- Journal Title
  
  Front Immunol.
  
  Volume: 13 Pages: 1010700-1010700
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K12772
[Journal Article] A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells.2022
- Author(s)
  Izuru Mizoguchi, Yasuhiro Katahira, Shinya Inoue, Eri Sakamoto, Aruma Watanabe, Yuma Furusaka, Atsushi Irie, Satoru Senju, Yasuharu Nishimura, Shusaku Mizukami, Kenji Hirayama, Sou Nakamura, Koji Eto, Hideaki Hasegawa, Takayuki Yoshimoto
- Journal Title
  
  ALTEX
  
  Volume: - Pages: 204-216
- DOI
  10.14573/altex.2111181
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08008, KAKENHI-PROJECT-21K11227, KAKENHI-PROJECT-21K12256, KAKENHI-PROJECT-22K16291, KAKENHI-PROJECT-22K08722, KAKENHI-PROJECT-21K07917
[Journal Article] Induction of potent antitumor immunity by intradermal <scp>DNA</scp> injection using a novel needle‐free pyro‐drive jet injector2022
- Author(s)
  Inoue Shinya、Mizoguchi Izuru、Sonoda Jukito、Sakamoto Eri、Katahira Yasuhiro、Hasegawa Hideaki、Watanabe Aruma、Furusaka Yuma、Xu Mingli、Yoneto Toshihiko、Sakaguchi Naoki、Terai Kazuhiro、Yamashita Kunihiko、Yoshimoto Takayuki
- Journal Title
  
  Cancer Science
  
  Volume: 114 Issue: 1 Pages: 34-47
- DOI
  10.1111/cas.15542
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K11227, KAKENHI-PROJECT-22K16291, KAKENHI-PROJECT-22K07504, KAKENHI-PROJECT-22K12772, KAKENHI-PROJECT-23K09087, KAKENHI-PROJECT-21K12256
[Journal Article] Interleukin-1β in peripheral monocytes is associated with seizure frequency in pediatric drug-resistant epilepsy.2021
- Author(s)
  Yamanaka G, Takamatsu T, Morichi S, Yamazaki T, Mizoguchi I, Ohno K, Watanabe Y, Ishida Y, Oana S, Suzuki S, Kashiwagi Y, Takata F, Sakuma H, Yoshimoto T, Kato M, Kawashima H
- Journal Title
  
  J Neuroimmunol.
  
  Volume: 352 Pages: 577475-577475
- DOI
  10.1016/j.jneuroim.2021.577475
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K08311, KAKENHI-PROJECT-20K08236, KAKENHI-PROJECT-20K17909, KAKENHI-PROJECT-18K11658, KAKENHI-PROJECT-21K12256
[Journal Article] A chaperone-like role for EBI3 in collaboration with calnexin under inflammatory conditions.2021
- Author(s)
  Watanabe A, Mizoguchi I, Hasegawa H, Katahira Y, Inoue S, Sakamoto E, Furusaka Y, Sekine A, Miyakawa S, Murakami F, Xu M, Yoneto T, Yoshimoto T.
- Journal Title
  
  Front Immunol.
  
  Volume: 12 Pages: 757669-757669
- DOI
  10.3389/fimmu.2021.757669
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K09105, KAKENHI-PROJECT-21K09779, KAKENHI-PROJECT-21K11227, KAKENHI-PROJECT-21K12256
[Journal Article] Microbial antigen-presenting extracellular vesicles derived from genetically modified tumor cells promote antitumor activity of dendritic cells2021
- Author(s)
  Tomoko Ito, Kikuya Sugiura, Aya Hasegawa, Wakana Ouchi, Takayuki Yoshimoto, Izuru Mizoguchi, Toshio Inaba, Katsuyuki Hamada, Masazumi Eriguchi, Yoshiyuki Koyama
- Journal Title
  
  Pharmaceutics
  
  Volume: 13 Issue: 1 Pages: 57-69
- DOI
  10.3390/pharmaceutics13010057
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K01390, KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K12806, KAKENHI-PROJECT-18K11658, KAKENHI-PROJECT-21K12256
[Journal Article] IL-23p19 and CD5 antigen-like form a possible heterodimeric cytokine and contribute to experimental autoimmune encephalomyelitis development.2021
- Author(s)
  Hasegawa H, Mizoguchi I, Orii N, Inoue S, Katahira Y, Yonteo T, Mingli X, Miyazaki T, Yoshimoto T
- Journal Title
  
  Sci Rep.
  
  Volume: 11(1) Issue: 1 Pages: 5266-5266
- DOI
  10.1038/s41598-021-84624-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-19K09105, KAKENHI-PROJECT-20K22885, KAKENHI-PROJECT-18K07333, KAKENHI-PROJECT-18K11658, KAKENHI-PROJECT-21K09779, KAKENHI-PROJECT-21K11227, KAKENHI-PROJECT-21K12256
[Journal Article] IL-12ヘテロダイマーサイトカインファミリーIL-12、IL-23、IL-352020
- Author(s)
  片平泰弘、井上槙也、溝口　出、善本隆之
- Journal Title
  
  医学のあゆみ「サイトカインのすべて」
  
  Volume: 別冊 Pages: 53-60
- Data Source
  KAKENHI-PROJECT-18K11658
[Journal Article] EBV-induced gene 3 augments IL-23Rα protein expression through a chaperone calnexin.2020
- Author(s)
  Mizoguchi I, Ohashi M, Hasegawa H, Chiba Y, Orii N, Inoue S, Kawana C, Xu M, Sudo K, Fujita K, Kuroda M, Hashimoto S, Matsushima K, and Yoshimoto T.
- Journal Title
  
  J Clin Invest.
  
  Volume: 130(11) Issue: 11 Pages: 6124-6140
- DOI
  10.1172/jci122732
- NAID
  120007052824
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06570, KAKENHI-PROJECT-18K07333, KAKENHI-PROJECT-18K11658
[Journal Article] Interleukin-27 exerts its antitumor effects by promoting differentiation of hematopoietic stem cells to M1 macrophages.2018
- Author(s)
  Chiba Y, Mizoguchi I, Furusawa J, Hasegawa H, Ohashi M, Xu M, Owaki T, Yoshimoto T.
- Journal Title
  
  Cancer Res.
  
  Volume: 78 Issue: 1 Pages: 182-194
- DOI
  10.1158/0008-5472.can-17-0960
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11030, KAKENHI-PROJECT-16J04160, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-18K07333, KAKENHI-PROJECT-18K11658
[Journal Article] Regulation of myelopoiesis by proinflammatory cytokines in infectious diseases.2018
- Author(s)
  Chiba Y, Mizoguchi I, Hasegawa H, Ohashi M, Orii N, Nagai T, Sugahara M, Miyamoto Y, Xu M, Owaki T, Yoshimoto T.
- Journal Title
  
  Cell. Mol. Life Sci.
  
  Volume: 75 Issue: 8 Pages: 1363-1376
- DOI
  10.1007/s00018-017-2724-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11030, KAKENHI-PROJECT-16J04160, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-18K07333, KAKENHI-PROJECT-18K11658
[Journal Article] Protective effects against tumors and infection by IL-27 through promotion of expansion and differentiation of hematopoietic stem cells into myeloid progenitors.2018
- Author(s)
  Orii N, Mizoguchi I, Chiba Y, Hasegawa H, Ohashi M, Xu M, Nagai T, Ochiai M, Mochizuki Y, Owaki T, Yoshimoto T.
- Journal Title
  
  Oncoimmunology
  
  Volume: - Issue: 5 Pages: e1421892-e1421892
- DOI
  10.1080/2162402x.2017.1421892
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K11030, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433, KAKENHI-PROJECT-18K07333, KAKENHI-PROJECT-18K11658
[Journal Article] Prediction of chemical respiratory and contact sensitizers by OX40L expression in dendritic cells using a novel 3D co-culture system.2017
- Author(s)
  Mizoguchi I, Ohashi M, Chiba Y, Hasegawa H, Xu M, Owaki T, Yoshimoto T.
- Journal Title
  
  Front. Immunol.
  
  Volume: 8 Pages: 929-929
- DOI
  10.3389/fimmu.2017.00929
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K11030, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433
[Journal Article] Expansion and differentiation of hematopoietic stem cells by IL-27 into myeloid progenitors to control infection2016
- Author(s)
  Furusawa J-I, Mizoguchi I, Chiba Y, Hisada M, Kobayashi F, Yoshida H, Nakae S, Tshuchida A, Matsumoto T, Ema H, Mizuguchi J, Yoshimoto T
- Journal Title
  
  PLoS Pathogen
  
  Volume: 12 Issue: 3 Pages: e1005507-e1005507
- DOI
  10.1371/journal.ppat.1005507
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08451, KAKENHI-PROJECT-16J04160, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433
[Journal Article] Expanding Diversity in Molecular Structures and Functions of the IL-6/IL-12 Heterodimeric Cytokine Family2016
- Author(s)
  Hasegawa Hideaki, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, and Takayuki Yoshimoto
- Journal Title
  
  Frontires in Immunolgy
  
  Volume: -
- DOI
  10.3389/fimmu.2016.00479
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16J04160, KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433
[Journal Article] Therapeutic potential of interleukin-27 against cancers in preclinical mouse models.2015
- Author(s)
  Mizoguchi, I., Chiba, Y., Furusawa, J., Xu, M., Tsunoda, R., Higuchi, K., and Yoshimoto,
- Journal Title
  
  Oncoimmunology
  
  Volume: 4(10) Issue: 10 Pages: e1042200-e1042200
- DOI
  10.1080/2162402x.2015.1042200
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433
[Journal Article] Potential clinical application of interleukin-27 as an antitumor agent.2015
- Author(s)
  Yoshimoto, T., Chiba, Y., Furusawa, J., Xu, M., Tsunoda, R., Higuchi, K., and Mizoguchi, I.
- Journal Title
  
  Cancer Sci.
  
  Volume: 106(9) Issue: 9 Pages: 1103-1110
- DOI
  10.1111/cas.12731
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07947, KAKENHI-PROJECT-15K08433
[Journal Article] Immunological control of chronic myeloid leukemia leading to treatment-free remission.2014
- Author(s)
  Mizoguchi, I., Yoshimoto, T., Katagiri, S., Furusawa, J., Chiba, Y., Mizuguchi, J., Tauchi, T., Ohyashiki, J. H., and Ohyashiki, K.
- Journal Title
  
  J. Hematol. Transfus.
  
  Volume: 2(3) Pages: 1024-1024
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790091
[Journal Article] Immunosurveillance markers may predict patients who can discontinue imatinib therapy without relapse.2014
- Author(s)
  Yoshimoto, T., Mizoguchi, I., Katagiri, S., Tauchi, T., Furusawa, J., Chiba, Y., Mizuguchi, J., Ohyashiki, J. H., and Ohyashiki, K.
- Journal Title
  
  Oncoimmunology
  
  Volume: 3
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24790091
[Journal Article] Contribution of IL-12/IL-35 common subunit p35 to maintaining the testicular immune privilege2014
- Author(s)
  Terayama H, Yoshimoto T, Hirai S, Naito M, Qu N, Hatayama N, Hayashi S, Mitobe K, Furusawa J, Mizoguchi I, Kezuka T, Goto H, Suyama K, Moriyama H, Sakabe K, Itoh M.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 4 Pages: e96120-e96120
- DOI
  10.1371/journal.pone.0096120
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-23500504, KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24590243, KAKENHI-PROJECT-24790091, KAKENHI-PROJECT-24791234, KAKENHI-PUBLICLY-25118727
[Journal Article] Down-regulated microRNA-148b in circulating PBMCs in chronic myeloid leukemia patients with undetectable minimal residual disease: A possible molecular classifier to stop imatinib safely.2014
- Author(s)
  Ohyashiki, J. H., Ohtsuki, K., Mizoguchi, I., Yoshimoto, T., Katagiri, S., Umezu, T., and Ohyashiki, K.
- Journal Title
  
  Drug Des. Devel. Ther.
  
  Volume: 8 Pages: 1151-1159
- DOI
  10.2147/dddt.s66812
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24790091, KAKENHI-PUBLICLY-25118727, KAKENHI-PROJECT-25830089
[Journal Article] IL-27 promotes nitric oxide production induced by LPS through STAT1, NF-kB and MAPKs2013
- Author(s)
  Shimizu, et al.
- Journal Title
  
  Immunobiology
  
  Volume: 218 Issue: 4 Pages: 628-634
- DOI
  10.1016/j.imbio.2012.07.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24659595, KAKENHI-PROJECT-24790091, KAKENHI-PUBLICLY-25118727
[Journal Article] Sustained up-regulation of effector natural killer cells in chronic myeloid leukemia after discontinuation of imatinib.2013
- Author(s)
  Mizoguchi, I., Yoshimoto, T., Katagiri, S., Mizuguchi, J., Tauchi, T., Kimura, Y., Inokuchi, K., Ohyashiki, J. H., and Ohyashiki, K.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104 Issue: 9 Pages: 1146-1153
- DOI
  10.1111/cas.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24790091, KAKENHI-PUBLICLY-25118727
[Journal Article] Pivotal Roles of T-Helper 17-Related Cytokines, IL-17, IL-22, and IL-23, in Inflammatory Diseases.2013
- Author(s)
  Qu N, Xu M, Mizoguchi I, Furusawa J, Kaneko K, Watanabe K, Mizuguchi J, Itoh M,Kawakami Y, Yoshimoto T.
- Journal Title
  
  Clin Dev Immunol.
  
  Volume: 2013:968549 Pages: 1-13
- DOI
  10.1155/2013/968549
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23240128, KAKENHI-PROJECT-23590475, KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24590243, KAKENHI-PROJECT-24659595, KAKENHI-PROJECT-24790091, KAKENHI-PUBLICLY-25118727, KAKENHI-PROJECT-25670506
[Journal Article] IL-27 enhances the expression of TRAIL and TLR3 in human melanomas and inhibits their tumor growth in cooperating with a TLR3 agonist poly(I:C) partly in TRAIL-dependent manner2013
- Author(s)
  Chiba Y, Mizoguchi K, Mitobe I, Higuchi K, Nagai H, Nishigori C, Mizuguchi J, Yoshimoto T
- Journal Title
  
  PLoS One
  
  Volume: 8(10) Issue: 10 Pages: e76159-e76159
- DOI
  10.1371/journal.pone.0076159
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590475, KAKENHI-PROJECT-24370058, KAKENHI-PROJECT-24659595, KAKENHI-PROJECT-24790091, KAKENHI-PUBLICLY-25118727
[Journal Article] サイトカインのすべて　IL-302012
- Author(s)
  溝口出　他
- Journal Title
  
  臨床免疫・アレルギー科
  
  Volume: 57 Pages: 188-196
- Data Source
  KAKENHI-PROJECT-24790091
[Journal Article] 抑制性サイトカインIL-10とIL-35による免疫反応の恒常性の維持2012
- Author(s)
  溝口出　他
- Journal Title
  
  細胞工学
  
  Volume: 31 Pages: 765-771
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] Induction of CD8+ T cell-mediated antitumor immunity by intradermal protein injection with a new pyro-derive jet injector.2023
- Author(s)
  Sonoda J, Mizoguchi I, Katahira Y, Hasegawa H, Yamashita K, Yoshimoto T.
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] イミキモド誘導性乾癬モデルにおけるストレス応答性MAPキナーゼASK1の役割とその作用機序2023
- Author(s)
  長谷川英哲、渡邉有麻、溝口　出、片平泰弘、関根碧水、山岸美宇、園田寿希心、宮川聡美、前田龍郎、原田和俊、大久保ゆかり、善本隆之
- Organizer
  第38回日本乾癬学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] 呼吸器と皮膚感作性物質の識別を可能にするTh2細胞株を応用した改良版2ステップDC/T共培養系の開発2023
- Author(s)
  溝口出、片平泰弘、長谷川英哲、渡邉有麻、関根碧水、園田寿樹心、山岸美宇、善本隆之
- Organizer
  第36回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] 生体組織接着性ポリアクリル酸／ポリビニルピロリドン複合体の形成挙動とその臨床応用2023
- Author(s)
  伊藤智子、中村賢一、大内彩歌、片平泰弘、長谷川英哲、溝口　出、善本隆之、小山義之
- Organizer
  第45回日本バイオマテリアル学会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] イミキモド誘導性乾癬モデルにおけるストレス応答性MAPキナーゼASK1の役割とその作用機序2023
- Author(s)
  長谷川英哲、渡邉有麻、溝口　出、片平泰弘、関根碧水、山岸美宇、園田寿希心、宮川聡美、前田龍郎、原田和俊、大久保ゆかり、善本隆之
- Organizer
  第38回日本乾癬学会総会・学術大会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] インターフェロン誘導機能を持つアデノウイルス由来の小分子核酸「VA-RNA」の細胞外小胞によるデリバリーとその抗腫瘍効果2023
- Author(s)
  小山義之、溝口　出、善本隆之、伊藤智子
- Organizer
  第39回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Protective effect of conditioned medium of immortalized stem cells from human exfoliated deciduous tooth on the peripheral neuropathy of experimental autoimmune neuritis.2022
- Author(s)
  Hasegawa H, Sakamoto E, Katahira Y, Miyakawa S, Murakami F, Inoue S, Watanabe A, Furusaka Y, SekineA, Owaki T, Mizoguchi I, Yoshimoto T.
- Organizer
  JSICR/MMCB 2022 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] Inhibitory effects of bone marrow-derived mesenchymal stem cells on tumor growth and its possible molecular mechanism.2022
- Author(s)
  Furusaka Y, Katahira Y, Hasegawa H, Umezu T, Mizoguchi I, Yoneto T, Yoshimoto T.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] アデノウイルス由来の小分子核酸「VA-RNA」を内包した細胞外小胞のIFN誘導機能と抗腫瘍効果2022
- Author(s)
  小山義之、伊藤智子、杉浦喜久弥、善本隆之、溝口出
- Organizer
  第9回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] Conditioned medium of immortalized stem cells from human exfoliated deciduous tooth exhibit protective effect on the peripheral neuropathy of experimental autoimmune neuritis.2022
- Author(s)
  Sakamoto E, Hasegawa H, Katahira Y, Miyakawa S, Watanabe A, Mizoguchi I, Yoshimoto T.
- Organizer
  第51回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] A novel alternative method for evaluation of sensitizing potential by T cell.2022
- Author(s)
  Mizoguchi I.
- Organizer
  ICCA-LRI workshop
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] 骨髄由来間葉系幹細胞の腫瘍増殖の抑制効果とその作用機序2022
- Author(s)
  米戸敏彦、古阪悠馬、片平泰弘、宮川聡美、長谷川英哲、溝口出、善本隆之
- Organizer
  第30回乳癌基礎研究会
- Data Source
  KAKENHI-PROJECT-22K12772
[Presentation] 不死化したヒト脱落乳歯歯髄幹細胞の培養上清投与による実験的自己免疫性神経炎の治療効果2022
- Author(s)
  善本隆之、長谷川英哲、片平泰弘、井上槙也、古阪悠馬、坂本恵梨、渡邉有麻、宮川聡美、大脇敏之、溝口出
- Organizer
  第21回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Conditioned medium of immortalized stem cells from human exfoliated deciduous tooth exhibit protective effect on the peripheral neuropathy of experimental autoimmune neuritis.2022
- Author(s)
  Sakamoto E, Hasegawa H, Katahira Y, Miyakawa S, Watanabe A, Mizoguchi I, Yoshimoto T.
- Organizer
  第51回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Protective effect of conditioned medium of immortalized stem cells from human exfoliated deciduous tooth on the peripheral neuropathy of experimental autoimmune neuritis.2022
- Author(s)
  Hasegawa H, Sakamoto E, Katahira Y, Miyakawa S, Murakami F, Inoue S, Watanabe A, Furusaka Y, SekineA, Owaki T, Mizoguchi I, Yoshimoto T.
- Organizer
  JSICR/MMCB 2022 Joint Symposium
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Inhibitory effects of bone marrow-derived mesenchymal stem cells on tumor growth and its possible molecular mechanism.2022
- Author(s)
  Furusaka Y, Katahira Y, Hasegawa H, Umezu T, Mizoguchi I, Yoneto T, Yoshimoto T.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] ヒトT細胞の活性化・分化誘導を指標に感作性・アレルギー誘発性を評価する新規代替法の開発2021
- Author(s)
  溝口出、片平泰弘、坂本恵梨、井上槙也、古阪悠馬、渡邉有麻、関根碧水、宮川聡美、長谷川英哲、徐　明利、米戸敏彦、善本隆之
- Organizer
  第34回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Protective effect of conditioned media of immortalized stem cells from human exfoliated deciduous teeth on the formation of acute pressure ulcers via HGF and VEGF.2021
- Author(s)
  Katahira Y, Inoue S, Hasegawa H, Watanabe A, Mizoguchi I, Yoshimoto T.
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] 新しい無針ジェットインジェクターによるDNAの皮内投与による抗原特異的CTLと抗体産生誘導の増強2021
- Author(s)
  井上槙也、溝口　出、片平泰弘、坂口奈央樹、寺居和宏、山下邦彦、善本隆之
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Intradermal inoculation of plasmid DNA by a novel pyro-drive jet injector induces potent antitumor immunity.2021
- Author(s)
  Inoue S, Mizoguchi I, Hideaki H, Katahira Y, Watanabe A, Sakaguchi N, Terai K, Yamashita K, Yoshimoto T.
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] IL-27/IL-35共通サブユニットEBI3によるシャペロン分子カルネキシンを介したIL-23Raの新しい蛋白質発現安定化機構2021
- Author(s)
  溝口　出、井上槙也、長谷川英哲、片平泰弘、善本隆之
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] 自己免疫性脳脊髄炎発症に関与する新規ヘテロダイマーサイトカインp19/CD5Lの同定とその機能解析2021
- Author(s)
  長谷川英哲、溝口　出、片平泰弘、井上槙也、渡邉有麻、坂本恵梨、古阪悠馬、米戸敏彦、徐明利、宮崎徹、善本隆之
- Organizer
  第85回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] Intradermal inoculation of plasmid DNA by a novel pyro-drive jet injector induces potent antitumor immunity.2021
- Author(s)
  Inoue S, Mizoguchi I, Hideaki H, Katahira Y, Watanabe A, Sakaguchi N, Terai K, Yamashita K, Yoshimoto T.
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] Protective effect of conditioned media of immortalized stem cells from human exfoliated deciduous teeth on the formation of acute pressure ulcers via HGF and VEGF.2021
- Author(s)
  Katahira Y, Inoue S, Hasegawa H, Watanabe A, Mizoguchi I, Yoshimoto T.
- Organizer
  第50回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] IL-27/IL-35共通サブユニットEBI3によるシャペロン分子カルネキシンを介したIL-23Raの新しい蛋白質発現安定化機構2021
- Author(s)
  溝口　出、井上槙也、長谷川英哲、片平泰弘、善本隆之
- Organizer
  第85回本インターフェロン・サイトカイン学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-21K12256
[Presentation] アレルギー感作性を評価する新規動物実験代替法の開発2020
- Author(s)
  溝口　出、川名千晶、長谷川英哲、折井直子、井上槙也、村上史浩、米戸敏彦、徐　明利、善本隆之
- Organizer
  東京医科大学記念館ポスター発表懇談会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] 活性化T細胞から産生されるIL-23p19サブユニットの役割2020
- Author(s)
  長谷川英哲、溝口　出、折井直子、川名千晶、井上槙也、村上史浩、米戸敏彦、徐　明利、善本隆之
- Organizer
  東京医科大学記念館ポスター発表懇談会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] 化粧品美白成分による白斑症誘発の作用機序の解明とそのin vitro評価法の開発2020
- Author(s)
  坂本恵梨、片平泰弘、井上槙也、古阪悠馬、渡邉有麻、長谷川英哲、米戸敏彦、徐　明利、溝口出、善本隆之
- Organizer
  第33回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] 化粧品美白成分による白斑症誘発の作用機序の解明とそのin vitro評価法の開発2020
- Author(s)
  坂本恵梨、片平泰弘、井上槙也、古阪悠馬、渡邉有麻、長谷川英哲、米戸敏彦、徐　明利、溝口出、善本隆之
- Organizer
  第33回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] 美白成分による自己免疫性白斑症誘発の作用機序の解明2020
- Author(s)
  坂本恵梨、片平泰弘、溝口　出、井上槙也、長谷川英哲、善本隆之
- Organizer
  第186回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] ESAT-6抗原提示エクソソームによる免疫活性化2020
- Author(s)
  小山義之、伊藤智子、江里口正純、善本隆之、溝口出、杉浦喜久弥、長谷川綾、大内若菜、稲葉俊夫
- Organizer
  第7回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] ESAT-6抗原提示エクソソームによる免疫活性化2020
- Author(s)
  小山義之、伊藤智子、江里口正純、善本隆之、溝口出、杉浦喜久弥、長谷川綾、大内若菜、稲葉俊夫
- Organizer
  第7回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] アレルギー感作性・誘発性を評価する新規動物実験代替法の開発2019
- Author(s)
  溝口　出、川名千晶、井上槙也、折井直子、長谷川英哲、米戸敏彦、徐　明利、善本隆之
- Organizer
  第8回医薬工3大学包括連携推進シンポジウム
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] Development of a novel alternative method for evaluation of sensitizing potential and allergenicity by measuring human T cell activation and differentiation in vitro.2019
- Author(s)
  Mizoguchi I, Inoue S, Orii N, Hasegawa H, Xu X, Yoshimoto T.
- Organizer
  第48回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] EBI3, one of subunits shared among the IL-12 cytokine family, plays a critical role in up-regulation of MHC class I during DC maturation.2019
- Author(s)
  Mizoguchi I, Hasegawa H, Orii N, Inoue S, Kawana C, Yoneto T, Xu M, Yoshimoto T.
- Organizer
  17th International Congress of Immunology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] IL-12ファミリーサイトカインの共通サブユニットEBI3による樹状細胞の成熟化におけるMHCクラスＩ発現の増強2019
- Author(s)
  井上槙也、溝口　出、長谷川英哲、折井直子、川名千晶、米戸敏彦、徐　明利、善本隆之
- Organizer
  第84回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-19K06570
[Presentation] 化学物質のアレルギー感作性・誘発性を評価する新規動物実験代替法の開発2019
- Author(s)
  溝口　出、川名千晶、井上槙也、折井直子、長谷川英哲、米戸敏彦、徐　明利、善本隆之
- Organizer
  第32回日本動物実験代替法学会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] A novel role for EBI3 to augment IL-23Rα protein expression through a lectin chaperone calnexin.2018
- Author(s)
  Mizoguchi, I., Ohashi, M., Hasegawa, H., Chiba, Y., Orii, N., Kan, S., Xu, M., Ochiai, N., Owaki, T., and Yoshimoto, T.
- Organizer
  東京医科大学記念館ポスター発表懇談会
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] ヒト間葉系幹細胞によるIL-27の関与2018
- Author(s)
  大脇敏之、溝口出、長谷川英哲、折井直子、善本隆之
- Organizer
  第181回東京医科大学医学会総会
- Data Source
  KAKENHI-PROJECT-17K11030
[Presentation] Prediction of chemical respiratory sensitizers by OX40L expression in dendritic cells using a new 3D co-culture system.2018
- Author(s)
  Yoshimoto, T., Hasegawa, H., Naoko, O., Xu, M., and Mizoguchi, I.
- Organizer
  The 4th International Conference on Toxicity Testing Alternatives & Translational Toxicology and the 2nd Asian Congress on Alternatives.
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] Prediction of chemical respiratory and contact sensitizers by OX40L expression in dendritic cells using a novel 3D co-culture system.2018
- Author(s)
  Ohashi, M., Mizoguchi, I., Chiba, Y., Hasegawa, H., Orii, N., Kan, S., Xu, M., Ochiai, N., Owaki, T., and Yoshimoto, T.
- Organizer
  東京医科大学記念館ポスター発表懇談会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] 化学物質の呼吸器感作性in vitro評価法の開発2018
- Author(s)
  溝口　出、折井直子、長谷川英哲、善本隆之
- Organizer
  第6期LRI研究報告会
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] ヒト間葉系幹細胞による免疫調節とIL-27の関係性2018
- Author(s)
  大脇敏之、菅原京加、落合央、溝口出、千葉佑規乃、長谷川英哲、折井直子、宮本泰則、弓場俊輔、善本隆之
- Organizer
  第16回日本再生医療学会総会
- Data Source
  KAKENHI-PROJECT-17K11030
[Presentation] ヒト臍帯血由来間葉系幹細胞による免疫調節とIL-27の関係性2018
- Author(s)
  大脇敏之、溝口出、杉山大介、善本隆之
- Organizer
  第83回日本インターフェロン・サイトカイン学会学術集会
- Data Source
  KAKENHI-PROJECT-17K11030
[Presentation] 新しい3次元共培養系を用いた呼吸器感作性代替法の開発2018
- Author(s)
  善本隆之、大橋美緒、長谷川英哲、折井直子、徐明利、大脇敏之、溝口　出
- Organizer
  第45回日本毒性学会学術年会
- Invited
- Data Source
  KAKENHI-PROJECT-18K11658
[Presentation] IL-27/IL-35共通サブユニットEBI3によるIL-23Rの新しい蛋白質発現安定化機構2017
- Author(s)
  溝口出、千葉祐規乃、長谷川英哲、大橋美緒、中村涼乃、折井直子、干詩宇、徐明利、大脇敏之、善本隆之
- Organizer
  第6回医薬工3大学包括連携推進シンポジウム
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] IL-27/IL-35共通サブユニットEBI3によるIL-23Rの新しい蛋白質発現安定化機構2017
- Author(s)
  溝口出、千葉祐規乃、長谷川英哲、大橋美緒、中村涼乃、折井直子、干詩宇、徐明利、大脇敏之、善本隆之
- Organizer
  第6回医薬工3大学包括連携推進シンポジウム
- Data Source
  KAKENHI-PROJECT-17K11030
[Presentation] A novel role for Epstein-Barr virus-induced gene 3 to augment IL-23 receptor α protein expression through a lectin chaperone calnexin.2017
- Author(s)
  Mizoguchi, I., Ohashi, M., Hasegawa, H., Chiba, Y., Xu, M., and Yoshimoto, T.
- Organizer
  第46回日本免疫学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] 炎症時の新しい蛋白質発現の増強機構2017
- Author(s)
  溝口　出
- Organizer
  Annual Meeting 2017医学総合研究所　研究発表会
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] A novel antitumor activity of IL-27 by promoting the differentiation of HSCs to antitumorigenic M1-like macrophages in tumor-bearing mice.2017
- Author(s)
  Chiba, Y., Ohashi, M., Hasegawa, H., Xu, M., Owaki, T., Mizoguchi, I., and Yoshimoto, T.
- Organizer
  The 2nd International Conference on Cytokine Signaling in Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] IL-27 induces antitumor activity by promoting differentiation of HSCs to M1-like antitumorigenic macrophages and their mobiliziation into tumor.2016
- Author(s)
  Chiba, Y., Mizoguchi, I., Hasegawa, H., Ohashi, M., C., Xu, M., and Yoshimoto, T.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] Promotion of expansion and differentiation of hematopoietic stem cells by IL-27 into myeloid progenitors to control infection in emergency myelopoiesis.2016
- Author(s)
  Yoshimoto, T., Furusawa, J., Chiba, Y., Xu, M., Hasegawa, H., Nakae, S., Kobayashi, F., Yoshida, H., and Mizoguchi, I. Ohashi, M., Hasegawa, H., and Mizoguchi, I.
- Organizer
  Symposium, 16th International Congress of Immunology
- Place of Presentation
  Melbourne, Australia
- Year and Date
  2016-08-21
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] A pivotal role for IL-23p19 produced by activated CD4+ T cells in development of EAE.2016
- Author(s)
  Hasegawa, H., Mizoguchi, I., Chiba, Ohashi, M., C., Xu, M., and Yoshimoto, T.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] アレルギー感作性をin vitroで評価する新しい方法の開発2016
- Author(s)
  溝口出、大橋美緒、長谷川英哲、千葉祐規乃、徐明利、善本隆之
- Organizer
  第5回医薬工3大学包括連携推進シンポジウム
- Place of Presentation
  東京
- Year and Date
  2016-06-18
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] Development of a novel 3D co-culture system for evaluation of respiratory sensitizing potential.2016
- Author(s)
  Ohashi, M., Mizoguchi, I., Hasegawa, H., Chiba, C., Xu, M., and Yoshimoto, T.
- Organizer
  第45回日本免疫学会総会・学術集会
- Place of Presentation
  沖縄
- Year and Date
  2016-12-05
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] Stop-imatinib CML患者末梢血単核球における免疫関連miRNAの意義2015
- Author(s)
  大屋敷一馬、溝口出、善本隆之、田内哲三、岡部聖一、片桐誠一朗、梅津知宏、大屋敷純子
- Organizer
  第7回血液疾患免疫療法研究会
- Place of Presentation
  東京
- Year and Date
  2015-09-26
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] 化学物質の呼吸器感作性in vitro評価法の開発2015
- Author(s)
  溝口出、千葉佑規乃、角田廉、徐明利、善本隆之
- Organizer
  第3期LRI研究報告会
- Place of Presentation
  東京
- Year and Date
  2015-08-28
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] 慢性骨髄性白血病患者における治療中止を成功させるための予測因子2015
- Author(s)
  片桐誠一朗、田内哲三、梅津知宏、田所健一、溝口出、善本隆之、大屋敷純子、大屋敷一馬
- Organizer
  第77回日本血液学会学術集会
- Place of Presentation
  金沢
- Year and Date
  2015-10-16
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] 化学物質の呼吸器感作性in vitro評価法の開発2015
- Author(s)
  善本隆之、千葉佑規乃、角田廉、徐明利、溝口出
- Organizer
  第28回日本動物実験代替法学会
- Place of Presentation
  横浜
- Year and Date
  2015-12-10
- Invited
- Data Source
  KAKENHI-PROJECT-15K07947
[Presentation] EBI3 functions as an intracellular molecule to regulate the development of colitis in naive CD4+CD25- T cells.2013
- Author(s)
  Mizoguchi, I. Mitobe, K., Tsunoda, R., Higuchi, K., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  15th International Congress of Immunology
- Place of Presentation
  Milan, Italy
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] EBI3 functions as an intracellular molecule to regulate the development of colitis in naive CD4+CD25- T cells.2013
- Author(s)
  Mizoguchi, I. Mitobe, K., Tsunoda, R., Higuchi, K., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  第78日本インターフェロン・サイトカイン学会総会(JSICR)/第21回マクロファージ分子細胞生物国際シンポジウム(MMCB)合同学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] EBI3 promotes IL-23-mediated signaling resulting in the development of colitis by enhancing IFN-g production.2013
- Author(s)
  Mizoguchi, I., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  第42回日本免疫学会総会
- Place of Presentation
  幕張
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] Cooperative growth inhibition of human melanomas by IL-27 and a TLR3 agonist poly(I:C) in TRAIL-dependent manner.2012
- Author(s)
  Mizoguchi et al.
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] EBI3 functions as an adaptor molecule associating with p62/SQSTM1 to regulate the development of colitis in CD4+ T cells.2012
- Author(s)
  Mizoguchi et al.
- Organizer
  第41回日本免疫学会総会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] Up-regulation of effector natural killer cells and effector memory CD8+ T cells in maintaining complete molecular response after imatinib discontinuation in chronic myeloid leukemia.
- Author(s)
  溝口出、片桐誠一朗、水口純一郎、大屋敷純子、大屋敷一馬、善本隆之
- Organizer
  第171回東京医科大学医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] Regulation of antitumor immune responses through differentiation and mobilization of hematopoietic stem cells by IL-27.
- Author(s)
  Chiba, Y., Mizoguchi, I., Hisada, M., Tsuchida, A., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] IL-27とPoly(I:C)による協調的TRAILとTLR3発現増強を介したメラノーマ腫瘍増殖のTRAIL依存的抑制
- Author(s)
  溝口出　他
- Organizer
  第87回東京医科大学・東京薬科大学・免疫アレルギー研究会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] IL-27 promotes the differentiation of hematopoietic stem cells into DC progenitor cells.
- Author(s)
  Furusawa, J., Chiba, Y., Mitobe, K., Mizoguchi, I., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  13th International Symposium on Dendritic Cells, DC2014
- Place of Presentation
  Tours, France
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] IL-27 exerts potent antitumor activity by promoting the differentiation of hematopoietic stem cells to M1-like antitumor macrophages and their mobilization.
- Author(s)
  Chiba, Y., Furusawa, J., Mizoguchi, I., Xu, M., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] CD4陽性T細胞から産生されるIL-12ファミリーサイトカイン構成因子EBI3の炎症性腸疾患発症への関与
- Author(s)
  溝口出　他
- Organizer
  第169回東京医科大学医学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24790091
[Presentation] IL-27 promotes the differentiation of hematopoietic stem cells into multipotent myeloid progenitor cells.
- Author(s)
  Furusawa, J., Chiba, Y., Mizoguchi, I., Xu, M., Mizuguchi, J., and Yoshimoto, T.
- Organizer
  第43回日本免疫学会総会・学術集会
- Place of Presentation
  京都
- Year and Date
  2014-12-10 – 2014-12-12
- Data Source
  KAKENHI-PROJECT-24790091

1. Yoshimoto Takayuki (80202406)

# of Collaborated Projects: 7 results

# of Collaborated Products: 75 results
2. OWAKI Toshiyuki (70453834)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. TERAYAMA Hayato

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. NAITO Munekazu

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
5. HIRAI Shuichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. ITO Tomoko

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 入江厚

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 宮川聡美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 小林富美恵

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 片平泰弘

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 河上裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 林省吾

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 畑山直之

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
14. 曲寧

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
15. 伊藤正裕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
16. 徐明利

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Mizoguchi Izuru 溝口 出

MIZOGUCHI Izuru 溝口 出

Research Projects

Research Products

Co-Researchers

Th2細胞活性化を指標にした呼吸器アレルギー誘発性評価の動物実験代替法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

新規無針注入器によるDNA・蛋白質の皮内投与によるワクチン効果と遺伝子治療増強

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel coculture system using human monocyte cell line-derived immature dendritic cells and T cells for evaluation of allergic sensitizing potentialPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A novel mechanism whereby EBI3, one of IL-27 cytokine subunits, augments target protein expression under inflammatory conditions

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of a novel alternative to animal testing for the evaluation of respiratory allergic sensitizing potential of chemicalsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Therapeutic effect of mesenchymal stem cells by anti-inflammatory cytokinesIL-27 and IL-35

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

A novel role for EBI3, a common subunit of IL-27 and IL-35, as a intracellular molecule in the augmentation of IL-23Ra protein expressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of immune responses by IL-23 p19, IL-27 EBI3 or their new heterodimerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Potent antitumor effects of the conditioned medium of bone marrow-derived mesenchymal stem cells via IGFBP-4.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] A Promising Needle-Free Pyro-Drive Jet Injector for Augmentation of Immunity by Intradermal Injection as a Physical Adjuvant2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chemical- and Drug-Induced Allergic, Inflammatory, and Autoimmune Diseases via Haptenation.2023

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Protective effects of conditioned media of immortalized stem cells from human exfoliated deciduous teeth on pressure ulcer formation.2023

Author(s)

Journal Title

Data Source

[Journal Article] A novel coculture system for assessing respiratory sensitizing potential by IL-4 in T cells.2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Induction of potent antitumor immunity by intradermal <scp>DNA</scp> injection using a novel needle‐free pyro‐drive jet injector2022

Author(s)

Journal Title

Mizoguchi Izuru 溝口出

MIZOGUCHI Izuru 溝口出