Ikushima Yoshiko 生島芳子

… Alternative Names

Ikushima Yoshiko M 生島芳子

IKUSHIMA Yoshiko 生島芳子

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Researcher Number	00571366
Other IDs
Affiliation (Current)	2025: 東北大学, 医学イノベーション研究所, 講師
Affiliation (based on the past Project Information) *help	2016 – 2021: 国立研究開発法人国立国際医療研究センター, その他部局等, 上級研究員 2014: 慶應義塾大学, 医学部, 研究員 2014: 独立行政法人国立国際医療研究センター, その他部局等, 上級研究員 2014: 独立行政法人国際医療研究センター, その他部局等, 上級研究員 2013: 慶應義塾大学, 医学部, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 49010:Pathological biochemistry-related / Pathological medical chemistry / Hematology Except Principal Investigator Biological Sciences
Keywords	Principal Investigator 膵島 / 細胞増殖 / 2型糖尿病 / MEK/ERKシグナル / 膵β細胞 / グルコース応答性インスリン分泌 / Mek/Erk / 開口放出 / Mek/Erk経路 / 糖尿病 … More / インスリン分泌 / Mek/Erkシグナル / 肥満 / インスリン / ニッチ / イギリス・スイス / 国際情報交換 / 造血幹細胞分裂 / ニッチ分子 / 幹細胞維持 / 単一細胞 / 娘幹細胞 / 造血幹細胞 … More Except Principal Investigator PO / Fbw / 多発性骨髄腫 / IL-2Rα / 低酸素 / VE-カドヘリン / CML / 細胞周期 / 血液腫瘍疾患 / 活性酸素 / ニッチ / 癌幹細胞 Less

膵β細胞の量・機能を制御する細胞内シグナルの同定Principal Investigator
- Principal Investigator
  
  生島芳子
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49010:Pathological biochemistry-related
- Research Institution
  National Center for Global Health and Medicine
Role of MEK/ERK signaling in pancreatic beta cells - to develop a novel treatment strategy for type 2 diaetesPrincipal Investigator
- Principal Investigator
  
  Ikushima Yoshiko M
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  National Center for Global Health and Medicine
Analyses of hematopoietic stem cell division patterns in biomimetic culture conditions and optimization of culture condition for hematopoietic stem cellsPrincipal Investigator
- Principal Investigator
  
  IKUSHIMA Yoshiko
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Hematology
- Research Institution
  Research Institute, International Medical Center of Japan
  Keio University
Analysis of Niche Regulation for Cancer Stem Cells
- Principal Investigator
  
  TOSHIO Suda
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Biological Sciences
- Research Institution
  Keio University

All 2021 2020 2019 2018 2017 2014 2013 Other

All Journal Article Presentation

[Journal Article] MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis2021
- Author(s)
  Ikushima Yoshiko Matsumoto、Awazawa Motoharu、Kobayashi Naoki、Osonoi Sho、Takemiya Seiichi、Kobayashi Hiroshi、Suwanai Hirotsugu、Morimoto Yuichi、Soeda Kotaro、Adachi Jun、Muratani Masafumi、Charron Jean、Mizukami Hiroki、Takahashi Noriko、Ueki Kohjiro
- Journal Title
  
  Diabetes
  
  Volume: 70 Issue: 7 Pages: 1519-1535
- DOI
  10.2337/db20-1295
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09037, KAKENHI-PROJECT-19K16547, KAKENHI-PROJECT-20K07280, KAKENHI-PROJECT-18K15075
[Journal Article] Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal2020
- Author(s)
  Arai Fumio、Stumpf Patrick S.、Ikushima Yoshiko M.、Hosokawa Kentaro、Roch Aline、Lutolf Matthias P.、Suda Toshio、MacArthur Ben D.
- Journal Title
  
  Cell Systems
  
  Volume: 11 Issue: 6 Pages: 640-652
- DOI
  10.1016/j.cels.2020.11.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08733, KAKENHI-PROJECT-19K16547, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-19K22638
[Journal Article] The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age2017
- Author(s)
  Hosokawa Kentaro、MacArthur Ben D.、Ikushima Yoshiko Matsumoto、Toyama Hirofumi、Masuhiro Yoshikazu、Hanazawa Shigemasa、Suda Toshio、Arai Fumio
- Journal Title
  
  Nature Communications
  
  Volume: 8(804) Issue: 1 Pages: 804-818
- DOI
  10.1038/s41467-017-00935-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09907, KAKENHI-PROJECT-16K19067, KAKENHI-PROJECT-26221309, KAKENHI-PROJECT-17H04208
[Journal Article] Prostaglandin E2 regulates murine hematopoietic stem/progenitorcells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.2013
- Author(s)
  Ikushima YM. Arai F, Hosokawa K, Toyama H, Takubo K, Furuyashiki T, Narumiya S, Suda T
- Journal Title
  
  Blood
  
  Volume: 121(11) Issue: 11 Pages: 1995-2007
- DOI
  10.1182/blood-2012-06-437889
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04866, KAKENHI-ORGANIZER-22130001, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23689049, KAKENHI-PROJECT-24689015, KAKENHI-PROJECT-24689041, KAKENHI-PLANNED-22130004, KAKENHI-PUBLICLY-23116512, KAKENHI-PUBLICLY-23118527
[Journal Article] Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.2013
- Author(s)
  Yamashita M, Nitta E, Nagamatsu G, Ikushima YM, Hosokawa K, Arai F, Suda T
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 441 Issue: 1 Pages: 196-201
- DOI
  10.1016/j.bbrc.2013.10.032
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-12J40105, KAKENHI-PROJECT-13J05828, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-23618011, KAKENHI-PUBLICLY-24116522, KAKENHI-PROJECT-24689041, KAKENHI-PROJECT-25670453, KAKENHI-PROJECT-25893234
[Journal Article] Enhanced Angptl/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.2013
- Author(s)
  Ikushima YM. Arai F, Nakamura Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, Suda T
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 130(1) Issue: 1 Pages: 20-25
- DOI
  10.1016/j.bbrc.2012.11.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J04866, KAKENHI-PLANNED-22122002, KAKENHI-PLANNED-22130004, KAKENHI-PROJECT-23249053, KAKENHI-PROJECT-24689041
[Presentation] MEK/ERKシグナルによるインスリン分泌制御のメカニズム2021
- Author(s)
  生島　芳子, 小林直樹, 粟澤元晴, 遅野井祥, 諏訪内浩紹, 守本祐一, 添田光太郎, 足立淳, 村谷匡史, 水上浩哉, 高橋倫子, 植木浩二郎
- Organizer
  第64回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] Roles of MEK/ERK signaling in pancreatic β cells under insulin resistant status2021
- Author(s)
  Ikushima YM, Awazawa M, Kobayashi N, Osonoi S, Suwanai H, Morimoto Y, Soeda K, Adachi J, Muratani M, Mizukami H, Takahashi N, Ueki K
- Organizer
  第64回日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] 膵β細胞の量と分泌能を制御するMEK/ERKシグナル2020
- Author(s)
  生島芳子, 小林直樹, 粟澤元晴, 諏訪内浩紹, 添田光太郎, 村谷匡史, 足立淳, 高橋倫子, 植木浩二郎
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] MEK/ERKシグナルによる膵β細胞制御2020
- Author(s)
  生島芳子, 小林直樹, 粟澤元晴, 諏訪内浩紹, 添田光太郎, 村谷匡史, 高橋倫子, 植木浩二郎
- Organizer
  第34回日本糖尿病・肥満動物学会
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] 膵β細胞の量と分泌能を制御するMEK/ERKシグナル2020
- Author(s)
  生島芳子,小林直樹,粟澤元晴,諏訪内浩紹,添田光太郎,村谷匡史,足立淳,高橋倫子,植木浩二郎
- Organizer
  第63回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] 膵β細胞制御におけるMek/Erkシグナルの役割の解明2019
- Author(s)
  生島芳子, 小林直樹, 粟澤元晴, 諏訪内浩紹, 添田光太郎, 村谷匡史, 高橋倫子, 植木浩二郎
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-19K16547
[Presentation] 糖尿病合併 NASH における血糖とインスリンによる腸内細菌叢の変化2019
- Author(s)
  添田光太郎，小林直樹，生島芳子，笹子敬洋，戸田郷太郎，粟澤元晴，門脇孝，植木浩二郎
- Organizer
  第33日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19067
[Presentation] 膵β細胞制御におけるMek/Erkシグナルの役割の解明2019
- Author(s)
  生島芳子，小林直樹，粟澤元晴，諏訪内浩紹，添田光太郎，村谷匡史，高橋倫子，植木浩二郎
- Organizer
  第62回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19067
[Presentation] Mek/Erkシグナルは膵β細胞の量と分泌能を制御する2019
- Author(s)
  生島芳子、小林直樹、粟澤元晴、竹宮聖一、諏訪内浩紹、添田光太郎、守本祐一、村谷匡史、高橋倫子、植木浩二郎
- Organizer
  第33日本糖尿病・肥満動物学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19067
[Presentation] 心筋におけるAktの役割の解明2018
- Author(s)
  添田光太郎，小林直樹，生島芳子，戸田郷太郎，笹子敬洋，竹宮聖一，野田哲生，門脇孝，植木浩二郎
- Organizer
  第 61 回日本糖尿病学会年次学術集会
- Data Source
  KAKENHI-PROJECT-16K19067
[Presentation] 単一細胞レベルでの娘細胞解析に基づくAngpt1の造血幹細胞分裂パターン決定における作用について2014
- Author(s)
  生島芳子, Ben D MacArthur, Patrick S Stumph, 細川健太郎, Alain Roch, Matthias P Lutolf, 須田年生, 新井文用
- Organizer
  第76回日本血液学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2014-10-31
- Data Source
  KAKENHI-PROJECT-25893234
[Presentation] Single cell-based analyses of cell division pattern of hematopoietic stem cells
- Author(s)
  Ikushima YM, MacArthur BD, Hosokawa K, Lutolf MP, Suda T, Arai F
- Organizer
  75th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  Sapporo, Japan
- Data Source
  KAKENHI-PROJECT-25893234

1. TOSHIO Suda (60118453)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
2. TAKUBO Keiyo (50502788)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. NAGAMATSU Go (70453545)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. ARAI Fumio (90365403)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
5. HOSOKAWA Kentaro (90569584)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
6. Kobayashi Naoki (80750728)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
7. Awazawa Motoharu (90466764)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
8. Suwanai Hirotsugu (60624939)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
9. Muratani Masafumi (50730199)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
10. Ueki Kohjiro (00396714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
11. MACARTHUR Ben D.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
12. STUMPF Patrich S

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. LUTOLF Matthias P.

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results

Ikushima Yoshiko 生島 芳子

Ikushima Yoshiko M 生島 芳子

IKUSHIMA Yoshiko 生島 芳子

Research Projects

Research Products

Co-Researchers

膵β細胞の量・機能を制御する細胞内シグナルの同定Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Role of MEK/ERK signaling in pancreatic beta cells - to develop a novel treatment strategy for type 2 diaetesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analyses of hematopoietic stem cell division patterns in biomimetic culture conditions and optimization of culture condition for hematopoietic stem cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of Niche Regulation for Cancer Stem Cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] MEK/ERK Signaling in β-Cells Bifunctionally Regulates β-Cell Mass and Glucose-Stimulated Insulin Secretion Response to Maintain Glucose Homeostasis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Machine Learning of Hematopoietic Stem Cell Divisions from Paired Daughter Cell Expression Profiles Reveals Effects of Aging on Self-Renewal2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The telomere binding protein Pot1 maintains haematopoietic stem cell activity with age2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prostaglandin E2 regulates murine hematopoietic stem/progenitorcells directly via EP4 receptor and indirectly through mesenchymal progenitor cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells.2013

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced Angptl/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells.2013

Author(s)

Journal Title

DOI

Data Source

[Presentation] MEK/ERKシグナルによるインスリン分泌制御のメカニズム2021

Author(s)

Organizer

Data Source

[Presentation] Roles of MEK/ERK signaling in pancreatic β cells under insulin resistant status2021

Author(s)

Organizer

Data Source

[Presentation] 膵β細胞の量と分泌能を制御するMEK/ERKシグナル2020

Author(s)

Organizer

Data Source

[Presentation] MEK/ERKシグナルによる膵β細胞制御2020

Author(s)

Organizer

Data Source

[Presentation] 膵β細胞の量と分泌能を制御するMEK/ERKシグナル2020

Author(s)

Organizer

Data Source

Ikushima Yoshiko 生島芳子

Ikushima Yoshiko M 生島芳子

IKUSHIMA Yoshiko 生島芳子