Hirayama Akiyoshi 平山明由

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HIRAYAMA Akiyoshi 平山明由

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Researcher Number	00572405
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 政策・メディア研究科(藤沢), 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 慶應義塾大学, 政策・メディア研究科(藤沢), 准教授 2020 – 2022: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任准教授 2016 – 2020: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 2015: 慶應義塾大学, 政策・メディア研究科, 助教 2015: 慶応大学, 先端生命科学研究所, 助教 … More 2015: 慶應義塾大学, 大学院政策メディア研究科, 特任助教 2014 – 2015: 慶應義塾大学, その他の研究科, 助教 2014: 慶應義塾大学, 政策・メディア研究所, 特任助教 2014: 慶應義塾大学, 政策メディア研究科および先端生命科学研究所, 特任助教 2013 – 2014: 慶應義塾大学, 政策・メディア研究科, 特任助教 2013: 慶應義塾大学, 政策・メディア研究科(藤沢), 特任助教 Less
Review Section/Research Field	Principal Investigator Basic Section 53040:Nephrology-related / General physiology / Digestive surgery Except Principal Investigator Basic Section 53040:Nephrology-related / Basic Section 56010:Neurosurgery-related / Medium-sized Section 58:Society medicine, nursing, and related fields / Transformative Research Areas, Section (III) / Basic Section 52010:General internal medicine-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Basic Section 56030:Urology-related … More / Basic Section 55010:General surgery and pediatric surgery-related / Tumor diagnosis / Epidemiology and preventive medicine / Kidney internal medicine / Complex systems Less
Keywords	Principal Investigator メタボロミクス / メタボローム解析 / バイオマーカー / ネフローゼ / 尿 / CE-MS / 細胞外小胞 / 低酸素 / トランスオミクス / オンコメタボライト … More / メタボローム / エクソソーム / 血漿 / マーカー / 腎疾患 / ポリアミン / 代謝 / 膵液 / 血清 / がん組織 / バイオマーカー探索 / 膵臓がん … More Except Principal Investigator メタボローム / フレイル / 間葉系幹細胞 / IDH変異 / IDH / がん代謝 / 神経膠腫 / メタボローム解析 / バイオマーカー / 遺伝子編集 / iPS細胞 / 腎臓内科 / 代謝物 / コホート研究 / 非感染性疾患 / メタボロミクス疫学 / 半月体形成性糸球体腎炎 / LncRNA / 腎線維化 / グルタミン / アスパラギン / エピゲノム / 栄養 / 代謝 / ライフスパン / 生殖細胞 / フルクトース代謝 / 糖尿病性腎臓病 / 糸球体濾過量推算式 / 腎血漿流量 / 神経性やせ症 / RPF推算式 / GFR推算式 / 糸球体高血圧 / メタボロミクス / 腎血漿流量（RPF) / 糸球体濾過量（GFR） / シスタチンC / サルコペニア / 腎血漿隆昌（RPF) / 糸球体濾過量（GFR) / 免疫 / 腎臓 / 炎症 / 網羅的代謝解析 / グリオーマ / iPS / 網羅的遺伝子解析 / 腎オルガノイド / ドライバー遺伝子変異 / 分化 / 多段階発癌 / ドライバー遺伝子 / 癌抑制遺伝子 / オルガノイド / がん遺伝子 / がん抑制遺伝子 / ヒトiPS細胞 / 発がん / 腎細胞癌 / 腸管関連 / NAFLD / NASH / 肝不全 / 腸肝関連 / 脂肪組織 / 肝微小環境 / 肝再生 / 脂肪肝炎 / 膵腫瘍 / 膵癌 / 膵液 / 膵悪性腫瘍 / 睡眠 / 気分・不安障害 / 疫学 / 代謝プロファイリング / 診断マーカー / キャピラリー電気泳動 / *メタボローム / 腎疾患 / バイオテクノロジー / 生体分子 / 癌 Less

腎疾患におけるlncRNAの役割の解明と新規治療法の開発
- Principal Investigator
  
  石本卓嗣
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Aichi Medical University
Biomarker discovery for kidney disease using metabolome analysis of extracellular vesiclesPrincipal Investigator
- Principal Investigator
  
  平山明由
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
Metabolic regulation of reproductive lifespan
- Principal Investigator
  
  林陽平
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Transformative Research Areas (A)
- Review Section
  
  Transformative Research Areas, Section (III)
- Research Institution
  Tohoku University
Usefulness of metabolite biomarker as a common pathway for the prevention of non-communicable diseases and frailty
- Principal Investigator
  
  武林亨
- Project Period (FY)
  2023 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 58:Society medicine, nursing, and related fields
- Research Institution
  Keio University
神経膠腫におけるがん代謝を標的とした治療法の開発
- Principal Investigator
  
  大場茂生
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Fujita Health University
間葉系幹細胞カラムとiPS細胞・遺伝子編集技術を融合した新規治療システム
- Principal Investigator
  
  古橋和拡
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Nagoya University
Development of next-generation immune and inflammatory control methods focusing on the mechanisms of inflammation regulation in the microenvironment of mesenchymal stem cells.
- Principal Investigator
  
  Maruyama Shoichi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Nagoya University
フルクトース代謝を標的とした糖尿病性腎臓病の病態解明と新規治療法の開発
- Principal Investigator
  
  石本卓嗣
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Aichi Medical University
Renal plasma flow (RPF) and accurate GFR equations utilizing metabolomics analysis
- Principal Investigator
  
  Yasuda Yoshinari
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 52010:General internal medicine-related
- Research Institution
  Nagoya University
Elucidation of the mechanism of tumorigenesis and development of new treatments using iPS cell-derived mutant IDH glioma model
- Principal Investigator
  
  OHBA SHIGEO
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Fujita Health University
Development of renal disease type screening method for clinical applicationPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Akiyoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53040:Nephrology-related
- Research Institution
  Keio University
がん細胞の飛び道具「エクソソーム」のトランスオミクス解析Principal Investigator
- Principal Investigator
  
  平山明由
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Research Institution
  Keio University
Development of integrated treatment for impaired liver regeneration on non-alcoholic steatohepatitis
- Principal Investigator
  
  SHIMADA Mitsuo
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  The University of Tokushima
Multistep carcinogenesis mechanism of renal cell carcinoma using human iPS cell-derived nephron induction and development of therapeutic platform
- Principal Investigator
  
  Baba Masaya
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Kumamoto University
Development of a novel diagnosis marker for kidney diseases by metabolome analysisPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Akiyoshi
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  General physiology
- Research Institution
  Keio University
Epidemiological study of prevention biomarker for mood and anxiety disorder by CE/MS based metabolimics
- Principal Investigator
  
  TAKEBAYASHI Toru
- Project Period (FY)
  2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Epidemiology and preventive medicine
- Research Institution
  Keio University
Development of novel diagnosis method for renal desease using metabolome analysis
- Principal Investigator
  
  OZAKI Takenori
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Fujita Health University
  Nagoya University
Elucidation of pancreatic cancer specific metabolism and biomarker discovery using metabolomicsPrincipal Investigator
- Principal Investigator
  
  HIRAYAMA Akiyoshi
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Digestive surgery
- Research Institution
  Keio University
Integrated analysis and detection of new therapeutic target aimed for improvement of prognosis in the patients with pancreatic malignant neoplasms
- Principal Investigator
  
  Ishiara Takeshi
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor diagnosis
- Research Institution
  Chiba University
Understanding cancer cell metabolism and biomarker discovery using metabolome analysis
- Principal Investigator
  
  SOGA Tomoyoshi
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  Keio University

All 2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 2012 2011 Other

All Journal Article Presentation Book Patent

[Book] Metabolomics: Methods and Protocols2015
- Author(s)
  Bjerrum, J.T., Gall, G.L., Giskeodegard, G.F., Cao, M.D., Bathen, T.F., Yin, P., Zhou, L., Zhao, X., Xu, G., Yin, P., Emwas, A.-H.M., Al-Talla, Z.A., Kharbatia, N., Yang, Y., Wakayama, M., Hirayama, A., Soga, T., Vettukattil, R., Bylesjo, M., Rantalainen, M., Ramana, P., Adams, E., Augustijns, P., A.V., et.al.
- Total Pages
  259
- Publisher
  Humana Press
- Data Source
  KAKENHI-PLANNED-22134007
[Book] 実験医学2014
- Author(s)
  平山明由、曽我朋義
- Publisher
  株式会社羊土社
- Data Source
  KAKENHI-PROJECT-25870719
[Book] トランスオミクスが拓く次世代の生命科学2014
- Author(s)
  平山明由、曽我朋義
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-25870719
[Journal Article] Metabolomic Analysis of Small Extracellular Vesicles Derived from Pancreatic Cancer Cells Cultured under Normoxia and Hypoxia2021
- Author(s)
  Hayasaka Ryosuke、Tabata Sho、Hasebe Masako、Ikeda Satsuki、Ohnuma Sumiko、Mori Masaru、Soga Tomoyoshi、Tomita Masaru、Hirayama Akiyoshi
- Journal Title
  
  Metabolites
  
  Volume: 11 Issue: 4 Pages: 215-215
- DOI
  10.3390/metabo11040215
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K08219, KAKENHI-PROJECT-20J12816, KAKENHI-PROJECT-17KK0199
[Journal Article] The use of a double coaxial electrospray ionization sprayer improves the peak resolutions of anionic metabolites in capillary ion chromatography-mass spectrometry.2020
- Author(s)
  Hirayama A, Tabata S, Kudo R, Hasebe M, Suzuki K, Tomita M, Soga T.
- Journal Title
  
  J Chromatogr A
  
  Volume: - Pages: 460914-460914
- DOI
  10.1016/j.chroma.2020.460914
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17KK0199, KAKENHI-PUBLICLY-18H04804, KAKENHI-PROJECT-18K08219
[Journal Article] A FLCN-TFE3 Feedback Loop Prevents Excessive Glycogenesis and Phagocyte Activation by Regulating Lysosome Activity2020
- Author(s)
  Mitsuhiro Endoh, Masaya Baba, Tamie Endoh, Akiyoshi Hirayama, Ayako Nakamura-Ishizu, Terumasa Umemoto, Michihiro Hashimoto, Kunio Nagashima, Tomoyoshi Soga, Martin Lang , Laura S Schmidt , W Marston Linehan, Toshio Suda
- Journal Title
  
  Cell Reports
  
  Volume: 30 Issue: 6 Pages: 1823-1834
- DOI
  10.1016/j.celrep.2020.01.042
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K06693, KAKENHI-PROJECT-19K22641, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-19H03688, KAKENHI-PROJECT-18K19619, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-16H06276
[Journal Article] Comprehensive Dipeptide Profiling and Quantitation by Capillary Electrophoresis and Liquid Chromatography Coupled with Tandem Mass Spectrometry2020
- Author(s)
  Ozawa Hitoshi、Hirayama Akiyoshi、Ishikawa Takamasa、Kudo Ryuhei、Maruyama Midori、Shoji Futaba、Doke Tomohito、Ishimoto Takuji、Maruyama Shoichi、Soga Tomoyoshi、Tomita Masaru
- Journal Title
  
  Analytical Chemistry
  
  Volume: 92 Issue: 14 Pages: 9799-9806
- DOI
  10.1021/acs.analchem.0c01258
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K08219
[Journal Article] Comprehensive Dipeptide Analysis Revealed Cancer-Specific Profile in the Liver of Patients with Hepatocellular Carcinoma and Hepatitis2020
- Author(s)
  Ozawa Hitoshi、Hirayama Akiyoshi、Shoji Futaba、Maruyama Midori、Suzuki Kumi、Yamanaka-Okumura Hisami、Tatano Hiroshi、Morine Yuji、Soga Tomoyoshi、Shimada Mitsuo、Tomita Masaru
- Journal Title
  
  Metabolites
  
  Volume: 10 Issue: 11 Pages: 442-442
- DOI
  10.3390/metabo10110442
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K11742, KAKENHI-PROJECT-18H02871, KAKENHI-PROJECT-18K08219
[Journal Article] Lactate production is a prioritized feature of adipocyte metabolism2019
- Author(s)
  Krycer James R.、Quek Lake-Ee、Francis Deanne、Fazakerley Daniel J.、Elkington Sarah D.、Diaz-Vegas Alexis、Cooke Kristen C.、Weiss Fiona C.、Duan Xiaowen、Kurdyukov Sergey、Zhou Ping-Xin、Tambar Uttam K.、Hirayama Akiyoshi、Ikeda Satsuki、Kamei Yushi、Soga Tomoyoshi、Cooney Gregory J.、James David E.
- Journal Title
  
  Journal of Biological Chemistry
  
  Volume: 295 Issue: 1 Pages: 83-98
- DOI
  10.1074/jbc.ra119.011178
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04804, KAKENHI-PROJECT-18K08219
[Journal Article] Trans-omic analysis reveals allosteric and gene regulation-axes for altered glucose-responsive liver metabolism associated with obesity2019
- Author(s)
  Kokaji Toshiya、Hatano Atsushi、Ito Yuki、Yugi Katsuyuki、Eto Miki、Ohno Satoshi、Fujii Masashi、Hironaka Ken-ichi、Egami Riku、Inoue Hiroshi、Uda Shinsuke、Kubota Hiroyuki、Suzuki Yutaka、Ikeda Kazutaka、Arita Makoto、Matsumoto Masaki、Nakayama Keiichi I.、Hirayama Akiyoshi、Soga Tomoyoshi、Kuroda Shinya
- Journal Title
  
  bioRxiv
  
  Volume: ―
- DOI
  10.1101/653758
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Journal Article] Folliculin Regulates Osteoclastogenesis Through Metabolic Regulation2018
- Author(s)
  3.Baba M, Endoh M, Ma W, Toyama H, Hirayama A, Nishikawa K, Takubo K, Hano H, Hasumi H, Umemoto T, Hashimoto M, Irie N, Esumi C, Kataoka M, Nakagata N, Soga T, Yao M, Kamba T, Minami T, Ishii M, and Suda T.
- Journal Title
  
  Journal of Bone and Mineral Research
  
  Volume: 33 Issue: 10 Pages: 1785-1798
- DOI
  10.1002/jbmr.3477
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0026, KAKENHI-PROJECT-18K18455, KAKENHI-PROJECT-18K19619, KAKENHI-PUBLICLY-17H05530, KAKENHI-PROJECT-18H05284, KAKENHI-PROJECT-18H02614, KAKENHI-PROJECT-18H02938, KAKENHI-PROJECT-16K07372, KAKENHI-PROJECT-16K11020, KAKENHI-PROJECT-16H06276, KAKENHI-PROJECT-17H03580
[Journal Article] Development of a sheathless CE-ESI-MS interface2018
- Author(s)
  Hirayama A, Abe H, Yamaguchi N, Tabata S, Tomita M, Soga T.
- Journal Title
  
  ELECTROPHORESIS
  
  Volume: 印刷中 Issue: 11 Pages: 1382-1389
- DOI
  10.1002/elps.201800017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-15K21364
[Journal Article] Reliability of plasma polar metabolite concentrations in a large-scale cohort study using capillary electrophoresis-mass spectrometry2018
- Author(s)
  Harada Sei、Hirayama Akiyoshi、Chan Queenie、Kurihara Ayako、Fukai Kota、Iida Miho、Kato Suzuka、Sugiyama Daisuke、Kuwabara Kazuyo、Takeuchi Ayano、Akiyama Miki、Okamura Tomonori、Ebbels Timothy M. D.、Elliott Paul、Tomita Masaru、Sato Asako、Suzuki Chizuru、Sugimoto Masahiro、Soga Tomoyoshi、Takebayashi Toru
- Journal Title
  
  PLOS ONE
  
  Volume: 13 Issue: 1 Pages: e0191230-e0191230
- DOI
  10.1371/journal.pone.0191230
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K00416, KAKENHI-PROJECT-15H04778, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-16K19259
[Journal Article] Changes of liver metabolites following hepatectomy with ischemia reperfusion towards liver regeneration2018
- Author(s)
  Y Saito, Y Morine, S Iwahashi, T Ikemoto, S Imura, H Yamanaka-Okumura, A Hirayama, T Soga, M Tomita, M Shimada
- Journal Title
  
  Ann Gastroenterol Surg
  
  Volume: - Issue: 3 Pages: 1-8
- DOI
  10.1002/ags3.12058
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K12738, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-18K16281, KAKENHI-PROJECT-18H02871, KAKENHI-PROJECT-16K10428
[Journal Article] Comparative analysis of cerebrospinal fluid metabolites in Alzheimer’s disease and idiopathic normal pressure hydrocephalus in a Japanese cohort.2018
- Author(s)
  1)Nagata Y, Hirayama A, Ikeda S, Shirahata A, Shoji F, Maruyama M, Kayano M, Bundo M, Hattori K, Yoshida S, Goto Y, Urakami K, Soga T, Ozaki K and Niida S.
- Journal Title
  
  Biomarker Research
  
  Volume: 6 Issue: 1 Pages: 1-11
- DOI
  10.1186/s40364-018-0119-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H04726, KAKENHI-PROJECT-15K21364
[Journal Article] Efficacy of Indigo naturalis in a Multicenter Randomized Controlled Trial of Patients with Ulcerative Colitis2017
- Author(s)
  .Naganuma M, Sugimoto S, Mitsuyama K, Kobayashi T, Yoshimura N, Ohi H, Tanaka S, Andoh A, Ohmiya N, Saigusa K, Yamamoto T, Morohoshi Y, Ichikawa H, Matsuoka K, Hisamatsu T, Watanabe K, Mizuno S, Suda W, Hattori M, Fukuda S, Hirayama A, Abe T, Watanabe M, Hibi T, Suzuki Y, Kanai T
- Journal Title
  
  Gastroenterology
  
  Volume: 4 Issue: 4 Pages: 935-947
- DOI
  10.1053/j.gastro.2017.11.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02534, KAKENHI-PROJECT-15J00981, KAKENHI-PROJECT-15K08564, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-18K07947, KAKENHI-PROJECT-16K09326
[Journal Article] Global metabolic reprogramming of colorectal cancer occurs at adenoma stage and is induced by MYC2017
- Author(s)
  Satoh K, Yachida S, Sugimoto M, Oshima M, Nakagawa T, Akamoto S, Tabata S, Saitoh K, Kato K, Sato S, Igarashi K, Aizawa Y, Kajino-Sakamoto R, Kojima Y, Fujishita T, Enomoto A, Hirayama A, Ishikawa T, Taketo MM, Kushida Y, Haba R, Okano K, Tomita M, Suzuki Y, Fukuda S, Aoki M, Soga T.
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 114 Issue: 37
- DOI
  10.1073/pnas.1710366114
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K07139, KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-26290045, KAKENHI-PUBLICLY-17H05654, KAKENHI-PLANNED-26111005, KAKENHI-PROJECT-26462860, KAKENHI-PROJECT-15K21364
[Journal Article] Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism2017
- Author(s)
  James R. Krycer, Satoshi Ohnoら全21名
- Journal Title
  
  Cell Reports
  
  Volume: 21 Issue: 12 Pages: 3536-3547
- DOI
  10.1016/j.celrep.2017.11.085
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K14864, KAKENHI-PROJECT-15H05582, KAKENHI-PROJECT-15K21364, KAKENHI-PLANNED-17H06300
[Journal Article] Thymidine Catabolism as a Metabolic Strategy for Cancer Survival2017
- Author(s)
  Tabata S, Yamamoto M, Goto H, Hirayama A, Ohishi M, Kuramoto T, Mitsuhashi A, Ikeda R, Haraguchi M, Kawahara K, Shinsato Y, Minami K, Saijo A, Hanibuchi M, Nishioka Y, Sone S, Esumi H, Tomita M, Soga T, Furukawa T, Akiyama SI
- Journal Title
  
  Cell Rep
  
  Volume: 19 Issue: 7 Pages: 1313-1321
- DOI
  10.1016/j.celrep.2017.04.061
- NAID
  120007001420
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26460201, KAKENHI-PROJECT-17K07221, KAKENHI-PROJECT-16K21361, KAKENHI-PROJECT-16H05309, KAKENHI-PROJECT-16K14619, KAKENHI-PROJECT-15K18413, KAKENHI-PROJECT-15K21364, KAKENHI-PROJECT-16K07121
[Journal Article] Metabolome analysis based on capillary electrophoresis-mass spectrometry2014
- Author(s)
  Hirayama, A., Wakayama, M., Soga, T.
- Journal Title
  
  Trends Anal. Chem.
  
  Volume: 61 Pages: 215-222
- DOI
  10.1016/j.trac.2014.05.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] メタボロミクス2014
- Author(s)
  平山明由、曽我朋義
- Journal Title
  
  生体の科学
  
  Volume: 65 Pages: 408-409
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] メタボローム解析技術とがんの代謝解析への応用2014
- Author(s)
  平山明由、曽我朋義
- Journal Title
  
  実験医学
  
  Volume: 32 Pages: 1205-1209
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] Global metabolic network reorganization by adaptive mutations allows fast growth of Escherichia coli on glycerol2014
- Author(s)
  Cheng, K., Lee, B., Masuda, T., Ito, T., Ikeda, K., Hirayama, A., Deng, L., Dong, J., Shimizu, K., Soga, T., Tomita, M., Palsson, B. O. & Robert, M.
- Journal Title
  
  Nat. Commun.
  
  Volume: 5 Issue: 1 Pages: 3233-3233
- DOI
  10.1038/ncomms4233
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] Development of quantitative method for determination of γ-glutamyl peptides by capillary electrophoresis tandem mass spectrometry: An efficient approach avoiding matrix effect2014
- Author(s)
  Hirayama, A., Igarashi, K., Tomita, M., Soga, T.
- Journal Title
  
  J Chromatogr A.
  
  Volume: 1369 Pages: 161-169
- DOI
  10.1016/j.chroma.2014.10.007
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] Metabolic profiling reveals new serum biomarkers for differentiating diabetic nephropathy.2012
- Author(s)
  Hirayama A
- Journal Title
  
  Anal Bioanal Chem.
  
  Volume: 404(10) Issue: 10 Pages: 3101-9
- DOI
  10.1007/s00216-012-6412-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590886, KAKENHI-PROJECT-23406027, KAKENHI-PROJECT-23659443, KAKENHI-PLANNED-22134007
[Journal Article] メタボローム解析に基づくがん特異的代謝の解明2012
- Author(s)
  平山明由
- Journal Title
  
  実験医学増刊
  
  Volume: 30 Pages: 25-30
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] メタボローム解析によるがんの代謝解析2012
- Author(s)
  平山明由
- Journal Title
  
  実験医学増刊
  
  Volume: 30 Pages: 203-208
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] Sheathless capillary electrophoresis-mass spectrometry with a high-sensitivity porous sprayer for cationic metabolome analysis2012
- Author(s)
  Hirayama, A.
- Journal Title
  
  Analyst
  
  Volume: 137 Issue: 21 Pages: 5026-5033
- DOI
  10.1039/c2an35492f
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] がん組織に特異的な代謝変化2012
- Author(s)
  平山明由
- Journal Title
  
  医学のあゆみ
  
  Volume: 241 Pages: 445-449
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] CE-MSメタボローム測定法2011
- Author(s)
  平山明由
- Journal Title
  
  Diabetes Frontier
  
  Volume: 22 Pages: 673-678
- Data Source
  KAKENHI-PLANNED-22134007
[Journal Article] メタボローム解析による癌代謝特性の包括的解明2011
- Author(s)
  平山明由
- Journal Title
  
  細胞工学
  
  Volume: 30 Pages: 25-29
- Data Source
  KAKENHI-PLANNED-22134007
[Patent] 全身性エリテマトーデスの検出方法2019
- Inventor(s)
  平山明由、曽我朋義、丸山彰一、秋山真一
- Industrial Property Rights Holder
  平山明由、曽我朋義、丸山彰一、秋山真一
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K08219
[Patent] 全身性エリテマトーデスの検出方法2018
- Inventor(s)
  平山明由、曽我朋義、丸山彰一、秋山真一
- Industrial Property Rights Holder
  平山明由、曽我朋義、丸山彰一、秋山真一
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2018-242371
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-18K08219
[Presentation] Targeting amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas2023
- Author(s)
  Shigeo Ohba, Takao Teranishi, Akiyoshi Hirayama, Keisuke Hitachi, Hisateru Yamaguchi, Manabu Natsumeda, Kensuke Tateishi, Russell O Pieper, Yuichi Hirose
- Organizer
  28th Annual Meeting and Education Day of the Society for Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K09243
[Presentation] IDH 変異型神経膠腫におけるグルタミン代謝を標的とした治療法の検討2022
- Author(s)
  大場茂生、平山明由、常陸圭介、山口央輝、棗田学、立石健祐、Joydeep Mukherjee、Russell O Pieper、廣瀬雄一
- Organizer
  第40回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09243
[Presentation] グリオーマにおけるアミノ酸代謝を標的とした治療法の検討2022
- Author(s)
  大場茂生、平山明由、常陸圭介、山口央輝4、Joydeep Mukherjee、Russell O Pieper、廣瀬雄一
- Organizer
  日本脳神経外科学会第81回学術総会
- Data Source
  KAKENHI-PROJECT-22K09243
[Presentation] Targeting amino acid metabolic vulnerabilities in IDH-mutant and IDH-wildtype gliomas2021
- Author(s)
  Shigeo Ohba, Akiyoshi Hirayama, Keisuke Hitachi, Hisateru Yamaguchi, Joydeep Mukherjee, Russell O Pieper, Yuichi Hirose
- Organizer
  26th Annual Meeting and Education Day of the Society for Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K09468
[Presentation] IDH変異型、IDH野生型グリオーマにおけるアミノ酸代謝を標的とした治療法の検討2021
- Author(s)
  大場茂生、平山明由、常陸圭介、山口央輝、 Joydeep Mukherjee 、Russell O Pieper、廣瀬雄一
- Organizer
  日本脳神経外科学会第80回学術総会
- Data Source
  KAKENHI-PROJECT-19K09468
[Presentation] IDH変異型、IDH野生型神経膠腫におけるアミノ酸代謝を標的とした治療法の検討2021
- Author(s)
  大場茂生、平山明由、常陸圭介、山口央輝、 Joydeep Mukherjee 、Russell O Pieper、廣瀬雄一
- Organizer
  第39回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-19K09468
[Presentation] メタボロミクスによるネフローゼ症候群の尿中バイオマーカー探索2020
- Author(s)
  平山明由、秋山真一、丸山彰一、曽我朋義
- Organizer
  第68回　質量分析総合討論会
- Data Source
  KAKENHI-PROJECT-18K08219
[Presentation] がん細胞が放出する細胞外小胞のメタボローム解析2019
- Author(s)
  早坂亮祐，平山明由，田畑祥，長谷部雅子，森大，大沼澄子，曽我朋義，冨田勝
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] メタボロミクスと疾患研究2019
- Author(s)
  平山　明由
- Organizer
  第36回　和漢医薬学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08219
[Presentation] Metabolomics in biology research2019
- Author(s)
  Akiyoshi Hirayama
- Organizer
  第42回　日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-18K08219
[Presentation] 低酸素膵臓がん細胞が放出する細胞外小胞のマルチオミックス解析2019
- Author(s)
  早坂亮祐、平山明由、田畑祥、長谷部雅子、森大、大沼澄子、曽我朋義、冨田勝
- Organizer
  第6回　日本細胞外小胞学会
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] 低酸素ストレス下でがん細胞が放出した細胞外小胞中の代謝物質量変化2019
- Author(s)
  早坂亮祐，平山明由，田畑祥，長谷部雅子，石川貴正，曽我朋義，冨田勝
- Organizer
  第7回　がんと代謝研究会
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] Metabolome analysis of cancer-derived extracellular vesicles under different oxygen concentration2019
- Author(s)
  Ryosuke Hayasaka, Akiyoshi Hirayama, Sho Tabata, Tomoyoshi Soga, Masaru Tomita
- Organizer
  15th Annual International Conference of the Metabolomics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] Metabolome analysis of pancreatic cancer-derived extracellular vesicles2019
- Author(s)
  Ryosuke Hayasaka, Akiyoshi Hirayama, Sho Tabata, Tomoyoshi Soga, Masaru Tomita
- Organizer
  ISEV2019
- Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] メタボローム解析技術を用いた糖尿病腎症をはじめとする各種腎疾患のバイオマーカー探索2018
- Author(s)
  平山明由
- Organizer
  第61回　日本糖尿病学会年次学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18K08219
[Presentation] がんエクソソームのメタボロミクス2018
- Author(s)
  平山明由
- Organizer
  第41回日本分子生物学会年会
- Invited
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] 膵臓がん細胞が放出する細胞外小胞のメタボローム解析2018
- Author(s)
  早坂亮祐、平山明由、田畑祥、曽我朋義、冨田勝
- Organizer
  第5回日本細胞外小胞学会JSEV
- Data Source
  KAKENHI-PUBLICLY-18H04804
[Presentation] 陰イオン性代謝物に特化した新規メタボローム分析法の開発2017
- Author(s)
  平山明由、田畑祥、曽我朋義
- Organizer
  第5回　がんと代謝研究会
- Data Source
  KAKENHI-PROJECT-15K21364
[Presentation] 疫学研究に必要なメタボローム解析の精度管理2017
- Author(s)
  平山明由
- Organizer
  第45回　産業中毒・生物学的モニタリング研究会
- Invited
- Data Source
  KAKENHI-PROJECT-15K21364
[Presentation] Development of anionic metabolome analysis method using capillary ion chromatography-mass spectrometry2017
- Author(s)
  Hirayama Akiyoshi、Tomita Masaru、Soga Tomoyoshi
- Organizer
  13th Annual International Conference of the Metabolomics Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21364
[Presentation] メタボロミクスを用いた新たな尿検査の可能性2016
- Author(s)
  平山明由、湯澤由紀夫
- Organizer
  日本臨床検査自動化学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Year and Date
  2016-09-22
- Invited
- Data Source
  KAKENHI-PROJECT-15K21364
[Presentation] メタボローム解析技術を用いたCKDの尿中バイオマーカー探索2015
- Author(s)
  平山明由、秋山真一、尾崎武徳、松尾清一、曽我朋義、丸山彰一
- Organizer
  第58回日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-25461217
[Presentation] メタボローム解析技術を用いたCKDの尿中バイオマーカー探索2015
- Author(s)
  平山明由、秋山真一、尾崎武徳、松尾清一、曽我朋義、丸山彰一
- Organizer
  日本腎臓学会学術総会
- Place of Presentation
  名古屋国際会議場（愛知県）
- Year and Date
  2015-06-05
- Invited
- Data Source
  KAKENHI-PROJECT-15K21364
[Presentation] キャピラリー電気泳動‐質量分析法（CE‐MS）を用いたすい臓がんのメタボローム解析2014
- Author(s)
  平山明由、三方林太郎、曽我朋義
- Organizer
  第87回　日本生化学会
- Place of Presentation
  国立京都国際会館
- Year and Date
  2014-10-16
- Data Source
  KAKENHI-PROJECT-25870719
[Presentation] メタボローム解析技術を用いたCKDのバイオマーカー探索
- Author(s)
  平山明由, 尾崎武徳, 秋山真一, 池田五月, 渡部瑠美, 丸山彰一, 松尾清一, 曽我朋義
- Organizer
  第57回日本腎臓学会学術大会
- Place of Presentation
  神奈川県（横浜パシフィコ）
- Year and Date
  2014-07-04 – 2014-07-06
- Data Source
  KAKENHI-PROJECT-25461217
[Presentation] CE-MS metabolomics; toward comprehensive understanding of central metabolism
- Author(s)
  平山明由、曽我朋義
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸ポートピアホテル
- Invited
- Data Source
  KAKENHI-PROJECT-25870719
[Presentation] キャピラリー電気泳動-質量分析法(CE-MS)を用いたすい臓がんのメタボローム解析
- Author(s)
  平山明由、多田素久、冨田勝、曽我朋義
- Organizer
  日本分析化学会　第62年会
- Place of Presentation
  近畿大学
- Data Source
  KAKENHI-PROJECT-25870719
[Presentation] キャピラリー電気泳動-質量分析法(CE-MS)を用いたすい臓がんのメタボローム解析
- Author(s)
  平山明由、三方林太郎、曽我朋義
- Organizer
  日本生化学会大会
- Place of Presentation
  国立京都国際会館(京都府京都市）
- Year and Date
  2014-10-15 – 2014-10-18
- Data Source
  KAKENHI-PROJECT-24501337

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# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
69. 広瀬雄一

# of Collaborated Projects: 0 results

# of Collaborated Products: 6 results
70. 金井隆典

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 久松理一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
72. 長沼誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
73. 山中仙示

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
74. 須田年生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 遠藤充浩

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 大野聡

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hirayama Akiyoshi 平山 明由

HIRAYAMA Akiyoshi 平山 明由

Research Projects

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Biomarker discovery for kidney disease using metabolome analysis of extracellular vesiclesPrincipal Investigator

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Development of renal disease type screening method for clinical applicationPrincipal Investigator

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がん細胞の飛び道具「エクソソーム」のトランスオミクス解析Principal Investigator

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Development of a novel diagnosis marker for kidney diseases by metabolome analysisPrincipal Investigator

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Hirayama Akiyoshi 平山明由

HIRAYAMA Akiyoshi 平山明由