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kawabe hiroshi  川辺 浩志

… Alternative Names

KAWABE Hiroshi  川辺 浩志

川辺 浩志  カワベ ヒロシ

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Researcher Number 00582454
Other IDs
  • ORCIDhttps://orcid.org/0000-0002-0761-5548
Affiliation (Current) 2025: 群馬大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help 2021 – 2025: 群馬大学, 大学院医学系研究科, 教授
2020: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス)
2019: 公益財団法人神戸医療産業都市推進機構, 上席研究員
2015: 公益財団法人先端医療振興財団, その他部局等, 上席研究員
Review Section/Research Field
Principal Investigator
Basic Section 44010:Cell biology-related / Basic Section 48040:Medical biochemistry-related / Neurochemistry/Neuropharmacology
Except Principal Investigator
Basic Section 55050:Anesthesiology-related
Keywords
Principal Investigator
超解像顕微鏡 / ユビキチン化 / シナプス / ユビキチン / 細胞内情報伝達 / 超高解像度顕微鏡 / スパイン
Except Principal Investigator
慢性痛 / 内因性鎮痛機構 / ノルアドレナリン … More / 内因性鎮痛 / 下行性抑制系 / 青斑核 / 前頭前野 Less
  • Research Projects

    (4 results)
  • Research Products

    (13 results)
  • Co-Researchers

    (6 People)
  •  限界の空間分解能で挑むシナプス内局所ユビキチン化で制御される液-液相分離の意義Principal Investigator

    • Principal Investigator
      川辺 浩志
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 44010:Cell biology-related
    • Research Institution
      Gunma University
  •  The roles of prefrontal cortex on the endogenous analgesic systems

    • Principal Investigator
      須藤 貴史
    • Project Period (FY)
      2023 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Gunma University
  •  Regulatory mechanisms of spine formation and synaptic plasticity by ubiquitination; toward the treatment of dementiaPrincipal Investigator

    • Principal Investigator
      Kawabe Hiroshi
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      Gunma University
      Foundation for Biomedical Research and Innovation at Kobe
  •  Regulation of neuronal spine by ubiquitinationPrincipal Investigator

    • Principal Investigator
      KAWABE Hiroshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
    • Research Field
      Neurochemistry/Neuropharmacology
    • Research Institution
      Foundation for Biomedical Research and Innovation at Kobe

All 2021 2020 2018 2017

All Journal Article Presentation Patent

  • [Journal Article] Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice2021

    • Author(s)
      Leitz Dominik H. W.、Duerr Julia、Mulugeta Surafel、Seyhan Agircan Ay?a、Zimmermann Stefan、Kawabe Hiroshi、Dalpke Alexander H.、Beers Michael F.、Mall Marcus A.
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 11 Pages: 6146-6146

    • DOI

      10.3390/ijms22116146

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07334
  • [Journal Article] Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice2021

    • Author(s)
      Koganezawa Noriko、Hanamura Kenji、Schwark Manuela、Krueger-Burg Dilja、Kawabe Hiroshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 582 Pages: 144-149

    • DOI

      10.1016/j.bbrc.2021.10.003

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07334
  • [Journal Article] NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair2021

    • Author(s)
      Yan Shen、Ripamonti Raphael、Kawabe Hiroshi、Ben-Yehuda Greenwald Maya、Werner Sabine
    • Journal Title

      Journal of Investigative Dermatology

      Volume: 22 Issue: 6 Pages: 6146-6146

    • DOI

      10.1016/j.jid.2021.09.033

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-20K07334
  • [Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020

    • Author(s)
      Luo, L.、19名略、Sinclair, J. L.、Stogsdill, J. A.、Traunmuller, L.、Wang, J.、Wortel, J.、 You, W.、 Abumaria, N.、 Beier, K. T.、 Brose, N.、 Burgess, H. A.、 Cepko, C. L.、 Cloutier, J. F.、 Eroglu, C.、 Goebbels, S.、 Kaeser, P. S.、 Kay, J. N.、 Lu, W.、 Luo, L.、 Mandai, K.、15名略、Kawabe, H.、 Craig, A. M.
    • Journal Title

      Neuron

      Volume: 106 Issue: 1 Pages: 37-65

    • DOI

      10.1016/j.neuron.2020.01.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K06503, KAKENHI-PLANNED-16H06461, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-15K21769, KAKENHI-PLANNED-16H06463
  • [Journal Article] The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.2020

    • Author(s)
      Ambrozkiewicz MC*, Borisova E, Schwark M, Ripamonti S, Schaub T, Smorodchenko A, Weber AI, Rhee HJ, Altas B, Yilmaz R, Mueller S, Piepkorn L, Horan ST, Straussberg R, Zaqout S, Jahn O, Dere E, Rosario M, Boehm-Sturm P, Borck G, Willig K, Rhee JS, Tarabykin V, and Kawabe H. * *=Corresponding authors
    • Journal Title

      Molecular Psychiatry

      Volume: 106 Issue: 6 Pages: 1980-1995

    • DOI

      10.1038/s41380-020-0714-8

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21769
  • [Journal Article] Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination2018

    • Author(s)
      Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M
    • Journal Title

      Cellular Microbiology

      Volume: e12846 Issue: 8

    • DOI

      10.1111/cmi.12846

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08798, KAKENHI-PROJECT-16K08800, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-17K19888, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-16H05220, KAKENHI-PROJECT-15K21769, KAKENHI-PROJECT-17K08841, KAKENHI-PUBLICLY-17H05682
  • [Journal Article] Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3?Ubiquitin Ligases and Intronic miR-1402018

    • Author(s)
      Ambrozkiewicz MC、Schwark M、Kishimoto-Suga M、Borisova E、Hori K、Salazar-L?zaro A、Rusanova A、Altas B、Piepkorn L、Bessa P、Schaub T、Zhang X、Rabe T、Ripamonti S、Ros?rio M、Akiyama H、Jahn O、Kobayashi T、Hoshino M、Tarabykin V、Kawabe H
    • Journal Title

      Neuron

      Volume: 100 Issue: 5 Pages: 1097-1115

    • DOI

      10.1016/j.neuron.2018.10.008

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538, KAKENHI-PROJECT-16K07021, KAKENHI-PROJECT-15H04268, KAKENHI-PROJECT-15K21769
  • [Journal Article] Deletion of Nedd4-2 results in progressive kidney disease in mice.2017

    • Author(s)
      Henshall, T. L., Manning, J. A., Alfassy, O. S., Goel, P., Boase, N. A., Kawabe, H., and Kumar, S.
    • Journal Title

      Cell Death and Differentiation

      Volume: 24 Issue: 12 Pages: 2150-2160

    • DOI

      10.1038/cdd.2017.137

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21769
  • [Journal Article] The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.2017

    • Author(s)
      Pei, G., Buijze, H., Liu, H., Moura-Alves, P., Goosmann, C., Brinkmann, V., Kawabe, H., Dorhoi, A., and Kaufmann, S.H.E.
    • Journal Title

      Autophagy

      Volume: 13 Issue: 12 Pages: 2041-2055

    • DOI

      10.1080/15548627.2017.1376160

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K21769
  • [Journal Article] NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.2017

    • Author(s)
      Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y.
    • Journal Title

      Nature Communication.

      Volume: 8 Issue: 1 Pages: 15662-15662

    • DOI

      10.1038/ncomms15662

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01252, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112002, KAKENHI-PROJECT-15K21769, KAKENHI-PROJECT-17H06166
  • [Patent] 記憶力向上のための認知症治療薬のスクリーニング方法2021

    • Inventor(s)
      川辺 浩志
    • Industrial Property Rights Holder
      川辺 浩志
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Data Source
      KAKENHI-PROJECT-20K07334
  • [Presentation] Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice2021

    • Author(s)
      Koganezawa Noriko、Hanamura Kenji、Schwark Manuela、Krueger-Burg Dilja、Kawabe Hiroshi
    • Organizer
      第95回日本薬理学会年会
    • Data Source
      KAKENHI-PROJECT-20K07334
  • [Presentation] 神経細胞発達におけるWWP E3ユビキチンリガーゼとmiR140の役割2017

    • Author(s)
      川辺 浩志
    • Organizer
      第40回日本神経科学大会
    • Data Source
      KAKENHI-PROJECT-15K21769
  • 1.  須藤 貴史 (60739621)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 2.  小幡 英章 (20302482)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 3.  YAMAMOTO Shouji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 4.  SUZUKI Atsushi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 5.  萬代 研二
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 6.  星野 幹雄
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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