kawabe hiroshi 川辺浩志

… Alternative Names

KAWABE Hiroshi 川辺浩志

川辺浩志カワベヒロシ

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Researcher Number	00582454
Other IDs	https://orcid.org/0000-0002-0761-5548
Affiliation (Current)	2025: 群馬大学, 大学院医学系研究科, 教授
Affiliation (based on the past Project Information) *help	2021 – 2025: 群馬大学, 大学院医学系研究科, 教授 2020: 公益財団法人神戸医療産業都市推進機構, その他部局等, 研究員(上席・主任研究員クラス) 2019: 公益財団法人神戸医療産業都市推進機構, 上席研究員 2015: 公益財団法人先端医療振興財団, その他部局等, 上席研究員
Review Section/Research Field	Principal Investigator Basic Section 44010:Cell biology-related / Basic Section 48040:Medical biochemistry-related / Neurochemistry/Neuropharmacology Except Principal Investigator Basic Section 48030:Pharmacology-related / Basic Section 55050:Anesthesiology-related
Keywords	Principal Investigator シナプス / ユビキチン / 超解像顕微鏡 / ユビキチン化 / 液ー液滴形成 / 細胞内情報伝達 / 超高解像度顕微鏡 / スパイン Except Principal Investigator タンパク質 / シナプス … More / ユビキチン化 / 慢性痛 / 内因性鎮痛機構 / ノルアドレナリン / 内因性鎮痛 / 下行性抑制系 / 青斑核 / 前頭前野 Less

限界の空間分解能で挑むシナプス内局所ユビキチン化で制御される液-液相分離の意義Principal Investigator
- Principal Investigator
  
  川辺浩志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Gunma University
ユビキチン化によるシナプス分子構築の制御機構：認知症創薬のための基礎的研究
- Principal Investigator
  
  六本木麗子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Gunma University
The roles of prefrontal cortex on the endogenous analgesic systems
- Principal Investigator
  
  須藤貴史
- Project Period (FY)
  2023 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Gunma University
Regulatory mechanisms of spine formation and synaptic plasticity by ubiquitination; toward the treatment of dementiaPrincipal Investigator
- Principal Investigator
  
  Kawabe Hiroshi
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Gunma University
  Foundation for Biomedical Research and Innovation at Kobe
Regulation of neuronal spine by ubiquitinationPrincipal Investigator
- Principal Investigator
  
  KAWABE Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Fund for the Promotion of Joint International Research (Home-Returning Researcher Development Research)
- Research Field
  
  Neurochemistry/Neuropharmacology
- Research Institution
  Foundation for Biomedical Research and Innovation at Kobe

All 2021 2020 2018 2017

All Journal Article Presentation Patent

[Journal Article] Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice2021
- Author(s)
  Leitz Dominik H. W.、Duerr Julia、Mulugeta Surafel、Seyhan Agircan Ay?a、Zimmermann Stefan、Kawabe Hiroshi、Dalpke Alexander H.、Beers Michael F.、Mall Marcus A.
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 22 Issue: 11 Pages: 6146-6146
- DOI
  10.3390/ijms22116146
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07334
[Journal Article] Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice2021
- Author(s)
  Koganezawa Noriko、Hanamura Kenji、Schwark Manuela、Krueger-Burg Dilja、Kawabe Hiroshi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 582 Pages: 144-149
- DOI
  10.1016/j.bbrc.2021.10.003
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07334
[Journal Article] NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair2021
- Author(s)
  Yan Shen、Ripamonti Raphael、Kawabe Hiroshi、Ben-Yehuda Greenwald Maya、Werner Sabine
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 22 Issue: 6 Pages: 6146-6146
- DOI
  10.1016/j.jid.2021.09.033
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07334
[Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020
- Author(s)
  Luo, L.、19名略、Sinclair, J. L.、Stogsdill, J. A.、Traunmuller, L.、Wang, J.、Wortel, J.、 You, W.、 Abumaria, N.、 Beier, K. T.、 Brose, N.、 Burgess, H. A.、 Cepko, C. L.、 Cloutier, J. F.、 Eroglu, C.、 Goebbels, S.、 Kaeser, P. S.、 Kay, J. N.、 Lu, W.、 Luo, L.、 Mandai, K.、15名略、Kawabe, H.、 Craig, A. M.
- Journal Title
  
  Neuron
  
  Volume: 106 Issue: 1 Pages: 37-65
- DOI
  10.1016/j.neuron.2020.01.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K06503, KAKENHI-PLANNED-16H06461, KAKENHI-PROJECT-18H02540, KAKENHI-PROJECT-15K21769, KAKENHI-PLANNED-16H06463
[Journal Article] The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.2020
- Author(s)
  Ambrozkiewicz MC*, Borisova E, Schwark M, Ripamonti S, Schaub T, Smorodchenko A, Weber AI, Rhee HJ, Altas B, Yilmaz R, Mueller S, Piepkorn L, Horan ST, Straussberg R, Zaqout S, Jahn O, Dere E, Rosario M, Boehm-Sturm P, Borck G, Willig K, Rhee JS, Tarabykin V, and Kawabe H. * *=Corresponding authors
- Journal Title
  
  Molecular Psychiatry
  
  Volume: 106 Issue: 6 Pages: 1980-1995
- DOI
  10.1038/s41380-020-0714-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21769
[Journal Article] Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination2018
- Author(s)
  Ogawa M, Matsuda R, Takada N, Tomokiyo M, Yamamoto S, Shizukusihi S, Yamaji T, Yoshikawa Y, Yoshida M, Tanida I, Koike M, Murai M, Morita H, Takeyama H, Ryo A, Guan JL, Yamamoto M, Inoue JI, Yanagawa T, Fukuda M, Kawabe H, Ohnishi M
- Journal Title
  
  Cellular Microbiology
  
  Volume: e12846 Issue: 8
- DOI
  10.1111/cmi.12846
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08798, KAKENHI-PROJECT-16K08800, KAKENHI-PROJECT-17K08522, KAKENHI-PROJECT-15K12749, KAKENHI-PROJECT-17K19888, KAKENHI-PLANNED-16H06575, KAKENHI-PROJECT-16H05220, KAKENHI-PROJECT-15K21769, KAKENHI-PROJECT-17K08841, KAKENHI-PUBLICLY-17H05682
[Journal Article] Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3?Ubiquitin Ligases and Intronic miR-1402018
- Author(s)
  Ambrozkiewicz MC、Schwark M、Kishimoto-Suga M、Borisova E、Hori K、Salazar-L?zaro A、Rusanova A、Altas B、Piepkorn L、Bessa P、Schaub T、Zhang X、Rabe T、Ripamonti S、Ros?rio M、Akiyama H、Jahn O、Kobayashi T、Hoshino M、Tarabykin V、Kawabe H
- Journal Title
  
  Neuron
  
  Volume: 100 Issue: 5 Pages: 1097-1115
- DOI
  10.1016/j.neuron.2018.10.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-16H06528, KAKENHI-PROJECT-18H02538, KAKENHI-PROJECT-16K07021, KAKENHI-PROJECT-15H04268, KAKENHI-PROJECT-15K21769
[Journal Article] Deletion of Nedd4-2 results in progressive kidney disease in mice.2017
- Author(s)
  Henshall, T. L., Manning, J. A., Alfassy, O. S., Goel, P., Boase, N. A., Kawabe, H., and Kumar, S.
- Journal Title
  
  Cell Death and Differentiation
  
  Volume: 24 Issue: 12 Pages: 2150-2160
- DOI
  10.1038/cdd.2017.137
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21769
[Journal Article] The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.2017
- Author(s)
  Pei, G., Buijze, H., Liu, H., Moura-Alves, P., Goosmann, C., Brinkmann, V., Kawabe, H., Dorhoi, A., and Kaufmann, S.H.E.
- Journal Title
  
  Autophagy
  
  Volume: 13 Issue: 12 Pages: 2041-2055
- DOI
  10.1080/15548627.2017.1376160
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K21769
[Journal Article] NEDD4 controls spermatogonial stem cell homeostasis and stress response by regulating messenger ribonucleoprotein complexes.2017
- Author(s)
  Zhou Z, Kawabe H, Suzuki A, Shinmyozu K, Saga Y.
- Journal Title
  
  Nature Communication.
  
  Volume: 8 Issue: 1 Pages: 15662-15662
- DOI
  10.1038/ncomms15662
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PUBLICLY-16H01252, KAKENHI-ORGANIZER-25112001, KAKENHI-PLANNED-25112002, KAKENHI-PROJECT-15K21769, KAKENHI-PROJECT-17H06166
[Patent] 記憶力向上のための認知症治療薬のスクリーニング方法2021
- Inventor(s)
  川辺　浩志
- Industrial Property Rights Holder
  川辺　浩志
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07334
[Presentation] Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice2021
- Author(s)
  Koganezawa Noriko、Hanamura Kenji、Schwark Manuela、Krueger-Burg Dilja、Kawabe Hiroshi
- Organizer
  第95回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-20K07334
[Presentation] 神経細胞発達におけるWWP E3ユビキチンリガーゼとmiR140の役割2017
- Author(s)
  川辺浩志
- Organizer
  第40回日本神経科学大会
- Data Source
  KAKENHI-PROJECT-15K21769

1. 畑田出穂 (50212147)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. 六本木麗子 (80719857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 須藤貴史 (60739621)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 小幡英章 (20302482)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中尾章人 (30748926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 平井宏和 (70291086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. YAMAMOTO Shouji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. SUZUKI Atsushi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 萬代研二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 星野幹雄

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

kawabe hiroshi 川辺 浩志

KAWABE Hiroshi 川辺 浩志

川辺 浩志 カワベ ヒロシ

Research Projects

Research Products

Co-Researchers

限界の空間分解能で挑むシナプス内局所ユビキチン化で制御される液-液相分離の意義Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ユビキチン化によるシナプス分子構築の制御機構：認知症創薬のための基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The roles of prefrontal cortex on the endogenous analgesic systems

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulatory mechanisms of spine formation and synaptic plasticity by ubiquitination; toward the treatment of dementiaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Regulation of neuronal spine by ubiquitinationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Congenital Deletion of Nedd4-2 in Lung Epithelial Cells Causes Progressive Alveolitis and Pulmonary Fibrosis in Neonatal Mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Super-resolved 3D-STED microscopy identifies a layer-specific increase in excitatory synapses in the hippocampal CA1 region of Neuroligin-3 KO mice2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] NEDD4-1 Is a Key Regulator of Epidermal Homeostasis and Wound Repair2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The murine ortholog of Kaufman oculocerebrofacial syndrome protein Ube3b regulates synapse number by ubiquitinating Ppp3cc.2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Molecular mechanisms of Streptococcus pneumoniae-targeted autophagy via pneumolysin, Golgi-resident Rab41, and Nedd4-1-mediated K63-linked ubiquitination2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3?Ubiquitin Ligases and Intronic miR-1402018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deletion of Nedd4-2 results in progressive kidney disease in mice.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The E3 ubiquitin ligase NEDD4 enhances killing of membrane-perturbing intracellular bacteria by promoting autophagy.2017

Author(s)

Journal Title

DOI

kawabe hiroshi 川辺浩志

KAWABE Hiroshi 川辺浩志

川辺浩志カワベヒロシ