Hatada Izuho 畑田出穂

… Alternative Names

HATADA Izuho 畑田出穂

畑田出穂ハタダイズホ

Less

Researcher Number	50212147
Other IDs
Affiliation (Current)	2025: 群馬大学, 生体調節研究所, 教授
Affiliation (based on the past Project Information) *help	2011 – 2025: 群馬大学, 生体調節研究所, 教授 2007 – 2009: Gunma University, 生体調節研究所, 准教授 2004 – 2006: Gunma University, Laboratory of Genome Science, Biosignal Genome Resource Center, Department of Molecular and Cellular Biology, Associate Professor, 生体調節研究所, 助教授 1999 – 2003: 群馬大学, 遺伝子実験施設, 助教授 1996: 国立循環器病センター研究所, バイオサイエンス部, 室員 1994: 国立循環器病センター研究所, バイオサイエンス部, 室員
Review Section/Research Field	Principal Investigator Biological Sciences / Molecular biology / Basic Section 56040:Obstetrics and gynecology-related / Basic Section 48040:Medical biochemistry-related / Medical genome science / System genome science / Developmental biology / Laboratory animal science / epigenetics Except Principal Investigator Basic Section 55020:Digestive surgery-related … More / Basic Section 48030:Pharmacology-related / Basic Section 44010:Cell biology-related / Basic Section 59040:Nutrition science and health science-related / Genome biology / Animal production science / Molecular biology / Applied animal science / Hygiene and public health / epigenetics / Biological Sciences Less
Keywords	Principal Investigator メチル化 / エピジェネティクス / インプリンティング / マイクロアレイ / 癌抑制遺伝子 / エピジェネティク / エピゲノム編集 / ゲノム編集 / エピゲノム / DNAメチル化 … More / miRNA / 卵子 / 癌 / 卵母細胞 / 癌遺伝子 / ゲノム / 子宮体癌 / 偽遺伝子 / Imprinting / Methylation / ヒストン / oocyte / germ cell / nuclear transplantation / methylation / imprinting / 生殖細胞 / 核移植 / DNAメチル / 分化 / エビジェネティクス / ゲノムワイド / 原始生殖細胞 / 原始卵胞 / 卵胞 / ゲノムインプリンティング / インシュリン / 糖尿病関連遺伝子 / DNAチップ / Microarray / トランスジェニックマウス / U2af1-rs1 / メチレーション / X inactivation / RNA / Xist / 小児癌 / Wilms腫瘍 / p57KIP2 / サイクリン依存性キナーゼインヒビター / Beckwith-Wiedemann症候群 / ゲノミックインプリンティング / ゲノムスキャンニング / 遺伝的刷り込み … More Except Principal Investigator シナプス / エピゲノム / エピジェネティクス / 肥満 / ゲノムインプリンティング / ES細胞 / DNAメチル化 / 核移植 / 卵母細胞 / 肝細胞がん / 癌関連線維芽細胞 / プロスタサイクリン / PTGIR / タンパク質 / ユビキチン化 / 液ー液滴形成 / ユビキチン / エピトランスクリプトーム / 視床下部 / 多階層オミクス解析 / 抗がん剤感受性 / O-GlcNAc / KRAS / 新規治療標的 / O-GlcNAc修飾 / 膵がん / インプリンティング / 父性遺伝 / CRISPR/Cas / FACS / 半数体 / リボソーム / ミトコンドリア / 翻訳停滞解消因子 / Development / In vitro culture / Genomic imprinting / Nuclear transfer / Oocytes / 体外培養 / 発生 / 対外培養 / miiRNA / 継世代影響 / 発がん / 胎児期曝露 / エピ変異 / miRNA / F2影響 / 肝腫瘍 / 妊娠期曝露 / 無機ヒ素 / 再生医療 / 腫瘍 / 単為発生胚 / インプリント遺伝子 / 移植医療 / テラトーマ / 腫瘍形成 / ゲノムインプリント / 単為発生 / 生殖細胞 / 性分化 / 卵子形成 / 胚発生 / ゲノミックインプリンティング / 生殖細胞分化 Less

限界の空間分解能で挑むシナプス内局所ユビキチン化で制御される液-液相分離の意義
- Principal Investigator
  
  川辺浩志
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 44010:Cell biology-related
- Research Institution
  Gunma University
ユビキチン化によるシナプス分子構築の制御機構：認知症創薬のための基礎的研究
- Principal Investigator
  
  六本木麗子
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48030:Pharmacology-related
- Research Institution
  Gunma University
Innovative therapeutic strategy, targeting for PTGIR positive cancer associated fibroblasts in hepatocellular carcinoma
- Principal Investigator
  
  調憲
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
Innovative Combination Immunotherapy Targets Vulnerability of KMT2 Mutant Uterine CancerPrincipal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56040:Obstetrics and gynecology-related
- Research Institution
  Gunma University
膵がん治療におけるO-GlcNAc分解酵素OGAの重要性とその分子機構の解明
- Principal Investigator
  
  川端麗香
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Gunma University
The role of epigenome and epitranscriptome in the development of obesity
- Principal Investigator
  
  河野大輔
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 59040:Nutrition science and health science-related
- Research Institution
  Gunma University
Histone methyltransferase KMT2 mutation-induced epigenomic abnormalities and endometrial cancer development and progressionPrincipal Investigator
- Principal Investigator
  
  Hatada Izuho
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Gunma University
A new therapeutic strategy for autoimmune diseases through epigenome editingPrincipal Investigator
- Principal Investigator
  
  Hatada Izuho
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  Gunma University
Analysis of the paternal transmission of obesity.
- Principal Investigator
  
  Morita Sumiyo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Genome biology
- Research Institution
  Gunma University
Functional analysis of stalled-ribosome rescue factors in mitochondria
- Principal Investigator
  
  Nameki Nobukazu
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Molecular biology
- Research Institution
  Gunma University
Establishment of simple culture system for haploid embryonic stem cells
- Principal Investigator
  
  Horii Takuro
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Animal production science
- Research Institution
  Gunma University
Is pseudogene fake?Principal Investigator
- Principal Investigator
  
  Hatada Izuho
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  System genome science
- Research Institution
  Gunma University
Studies on epimutations that are involved in multigenerational effects of environmental chemicals in mice
- Principal Investigator
  
  Nohara Keiko
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene and public health
- Research Institution
  National Institute for Environmental Studies
Establishment of pluripotent stem cells with low tumorigenesity by use of genomic imprinting
- Principal Investigator
  
  HORII Takuro
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  epigenetics
- Research Institution
  Gunma University
Why methylation and demethylation occur simultaneously in cancersPrincipal Investigator
- Principal Investigator
  
  HATADA Izuho
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  epigenetics
- Research Institution
  Gunma University
マイクロアレイによる肺癌のメチル化網羅的解析と診断・治療のターゲットの検討Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
網羅的エピゲノムデータのモチーフ解析によるmiRNAの転写制御への関与の検討Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
プロモーターメチル化アレイによる肺癌のゲノムワイドなエピジェネティク解析Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
脱メチル化ターゲット配列データベースの作成と共通モチーフの解明Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
卵胞培養系を用いたハイスループット遺伝子機能解析Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
成長期卵母細胞におけるSETドメインを持つ遺伝子の網羅的解析Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
DNAチップを用いたハイスループットなメチル化検出システムPrincipal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
雄性生殖細胞に卵子発生プログラムを書き込むことは可能か?
- Principal Investigator
  
  OBATA Yayoi
- Project Period (FY)
  2003 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo University of Agriculture
Is methylation of histone required for imprinting?Principal Investigator
- Principal Investigator
  
  HATADA Izuho
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Developmental biology
- Research Institution
  Gunma University
Control of epigenetic modification for oocytes genome
- Principal Investigator
  
  KONO Tomohiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied animal science
- Research Institution
  TOKYO UNIVERSITY OF AGRICULTURE
インプリンティングを指標とした糖尿病関連遺伝子の検索Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
Development of method to make oocyte from male germ cellsPrincipal Investigator
- Principal Investigator
  
  HATADA Izuho
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Laboratory animal science
- Research Institution
  Gunma University
Microarrayを利用したDNAメチル化のゲノムスキャンニングPrincipal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
インプリンティンブを指標とした糖尿病関連遺伝子の検索Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
インプリンティングを指標とした癌関連遺伝子の組織的単離法Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Gunma University
インプリンティングを利用した癌抑制遺伝子の組織的単離法Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
X染色体不活性化をおこなう機能的RNA-Xistの標的の探索Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  Gunma University
インプリンティングの分子機構の解明Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  Gunma University
サイクリン依存性キナーゼインヒビターp57KIP2の小児癌への関与の検討Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  National Cardiovascular Center Research Institute
遺伝的刷り込み現象を示す遺伝子SP2のトランスジェニックマウスによる解析Principal Investigator
- Principal Investigator
  
  畑田出穂
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Molecular biology
- Research Institution
  National Cardiovascular Center Research Institute

[Book] Editing of DNA Methylation Using dCas9-Peptide Repeat and scFv-TET1 Catalytic Domain Fusions. Morita S, Horii T, Hatada I. Methods Mol Biol.2018
- Author(s)
  Morita S, Horii T, Hatada I.
- Total Pages
  288
- Publisher
  Springer Nature
- ISBN
  9781493977734
- Data Source
  KAKENHI-PROJECT-17H03613
[Book] All About ゲノム編集2016
- Author(s)
  畑田出穂、森田純代、堀居拓郎
- Total Pages
  240
- Publisher
  羊土社
- Data Source
  KAKENHI-PROJECT-15K07687
[Book] Epigenetic Instability in Embryonic Stem Cells2013
- Author(s)
  T Horii and I Hatada
- Total Pages
  16
- Publisher
  INTECH
- Data Source
  KAKENHI-PROJECT-24613002
[Book] The epigenomics of cancer. In Omics perspective of cancer Cho, William C.S.(Ed.)2010
- Author(s)
  Hatada I
- Total Pages
  269
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20016002
[Book] The epigenomics of cancer. In Omics perspective of cancer Cho, William C.S.(Ed.)2010
- Author(s)
  Hatada I
- Total Pages
  269
- Publisher
  Springer
- Data Source
  KAKENHI-PROJECT-20012009
[Book] Genomic-wide DNA Methylation Profiling Methods From RLGS to MIAMI In Progress in DNA Methylation Research2008
- Author(s)
  Hatada I
- Total Pages
  256
- Publisher
  Nova Publishes
- Data Source
  KAKENHI-PROJECT-20016002
[Book] Genomic-wide DNA Methylation Profiling. Methods-From RLGS to MIAMI. In Progress in DNA Methylation Research2008
- Author(s)
  Hatada I
- Total Pages
  256
- Publisher
  Nova Publishes
- Data Source
  KAKENHI-PROJECT-20012009
[Book] Genomic-wide DNA Methylation Profiling Methods-From RLGS to Miami. In Progress in DNA Methylation Research2007
- Author(s)
  Hatada I
- Publisher
  Nova Publishers (in press)
- Data Source
  KAKENHI-PROJECT-18016003
[Book] Genomic-wide DNA Methylation Profiling Methods- From RLGS to Miami. In Progress in DNA Methylation Research2007
- Author(s)
  Hatada I
- Publisher
  Nova Publishers (in press)
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Multiplexed genome editing by in vivo electroporation of Cas9 ribonucleoproteins effectively induces endometrial carcinoma in mice2022
- Author(s)
  Kobayashi Ryosuke、Kawabata‐Iwakawa Reika、Sugiyama Makoto、Oyama Tetsunari、Ohtsuka Masato、Horii Takuro、Morita Sumiyo、Nishiyama Masahiko、Hatada Izuho
- Journal Title
  
  International Journal of Cancer
  
  Volume: 152 Issue: 11 Pages: 2331-2337
- DOI
  10.1002/ijc.34342
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K15026, KAKENHI-PROJECT-20H03431, KAKENHI-PROJECT-20J01824
[Journal Article] Synergistic Upregulation of Target Genes by TET1 and VP64 in the dCas9-SunTag Platform.2020
- Author(s)
  Morita S, Horii T, Kimura M, Hatada I.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 21 Issue: 5 Pages: 1574-1574
- DOI
  10.3390/ijms21051574
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-17H03613, KAKENHI-PROJECT-19H03143
[Journal Article] Successful generation of epigenetic disease model mice by targeted demethylation of the epigenome.2020
- Author(s)
  Horii T, Morita S, Hino S, Kimura M, Hino Y, Kogo H, Nakao M & Hatada I
- Journal Title
  
  Genome Biology
  
  Volume: 21(1) Issue: 1 Pages: 77-77
- DOI
  10.1186/s13059-020-01991-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03613, KAKENHI-PROJECT-19H03143, KAKENHI-PROJECT-18K19479, KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K07262, KAKENHI-PROJECT-18H02618, KAKENHI-PROJECT-20H04108
[Journal Article] Targeted DNA demethylation of the Fgf21 promoter by CRISPR/dCas9-mediated epigenome editing.2020
- Author(s)
  Hanzawa N, Hashimoto K, Yuan X, Kawahori K, Tsujimoto K, Hamaguchi M, Tanaka T, Nagaoka Y, Nishina H, Morita S, Hatada I, Yamada T, Ogawa Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 10 Issue: 1 Pages: 5181-5181
- DOI
  10.1038/s41598-020-62035-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K06607, KAKENHI-PROJECT-19K18000, KAKENHI-PROJECT-17H03613, KAKENHI-PROJECT-18H02859, KAKENHI-PROJECT-17K01840, KAKENHI-PROJECT-19K09018, KAKENHI-PROJECT-20H03381
[Journal Article] Differentiation Therapy by Epigenetic Reconditioning Exerts Antitumor Effects on Liver Cancer Cells2018
- Author(s)
  Gailhouste Luc、Liew Lee Chuen、Yasukawa Ken、Hatada Izuho、Tanaka Yasuhito、Nakagama Hitoshi、Ochiya Takahiro
- Journal Title
  
  Molecular Therapy
  
  Volume: 26 Issue: 7 Pages: 1840-1854
- DOI
  10.1016/j.ymthe.2018.04.018
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03613
[Journal Article] Epigenetic reprogramming using 5-azacytidine promotes an anti-cancer response in pancreatic adenocarcinoma cells.2018
- Author(s)
  Gailhouste L, Liew LC, Hatada I, Nakagama H, Ochiya T.
- Journal Title
  
  Cell Death Dis.
  
  Volume: 9 Issue: 5 Pages: 468-468
- DOI
  10.1038/s41419-018-0487-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03613
[Journal Article] Editing of DNA Methylation Using dCas9-Peptide Repeat and scFv-TET1 Catalytic Domain Fusions2018
- Author(s)
  Morita Sumiyo、Horii Takuro、Hatada Izuho
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1767 Pages: 419-428
- DOI
  10.1007/978-1-4939-7774-1_23
- ISBN
  9781493977734, 9781493977741
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17H03613, KAKENHI-PROJECT-16K07194
[Journal Article] Genome Engineering Using Haploid Embryonic Stem Cells.2017
- Author(s)
  Horii T, Hatada I.
- Journal Title
  
  Prog Mol Biol Transl Sci.
  
  Volume: 152 Pages: 83-94
- DOI
  10.1016/bs.pmbts.2017.09.001
- Peer Reviewed
- Data Source
  KAKENHI-PUBLICLY-17H05613, KAKENHI-PROJECT-15K07687
[Journal Article] Genome Editing of Mouse by Cytoplasmic Injection.2017
- Author(s)
  Horii T, Hatada I.
- Journal Title
  
  Methods Mol Biol.
  
  Volume: 1630 Pages: 55-66
- DOI
  10.1007/978-1-4939-7128-2_5
- ISBN
  9781493971275, 9781493971282
- Data Source
  KAKENHI-PROJECT-15K07687
[Journal Article] Efficient generation of conditional knockout mice via sequential introduction of lox sites.2017
- Author(s)
  Horii T, Morita S, Kimura M, Terawaki N, Shibutani M, Hatada I.
- Journal Title
  
  Scientific Reports
  
  Volume: 7 Issue: 1 Pages: 7891-7891
- DOI
  10.1038/s41598-017-08496-8
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-17H05613, KAKENHI-PROJECT-15K07687
[Journal Article] 肥満のエピジェネティクスとその世代間継承2016
- Author(s)
  畑田出穂、森田純代
- Journal Title
  
  実験医学増刊,　エピゲノム研究　修飾の全体像の理解から先制・個別化医療へ, 羊土社
  
  Volume: 34 Pages: 1617-1621
- Data Source
  KAKENHI-PROJECT-16K07194
[Journal Article] Targeted DNA demethylation in vivo using dCas9-peptide repeat and scFv-TET1 catalytic domain fusions.2016
- Author(s)
  Morita S, Noguchi H, Horii T, Nakabayashi K, Kimura M, Okamura K, Sakai A, Nakashima H, Hata K, Nakashima K, Hatada I
- Journal Title
  
  Nat Biotechnol.
  
  Volume: 34 Issue: 10 Pages: 1060-1065
- DOI
  10.1038/nbt.3658
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-15K14452, KAKENHI-PROJECT-15K07687, KAKENHI-PROJECT-16K07137
[Journal Article] Regulation of CpG methylation by Dnmt and Tet in pluripotent stem cells2016
- Author(s)
  Horii T, Hatada I.
- Journal Title
  
  J. Reprod. Dev.
  
  Volume: 62 Issue: 4 Pages: 331-335
- DOI
  10.1262/jrd.2016-046
- NAID
  130005406815
- ISSN
  0916-8818, 1348-4400
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07687
[Journal Article] 5-hydroxymethylcytosine marks sites of DNA damage and promotes genome stability.2016
- Author(s)
  Georgia R. Kafer, Xuan Li, Takuro Horii, Isao Suetake, Shoji Tajima, Izuho Hatada, Peter M. Carlton.
- Journal Title
  
  Cell Reports
  
  Volume: 14 Issue: 6 Pages: 1283-1292
- DOI
  10.1016/j.celrep.2016.01.035
- NAID
  120005707793
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25291025, KAKENHI-PROJECT-15K07687
[Journal Article] Genome Editing Using Mammalian Haploid Cells2015
- Author(s)
  Horii T, Hatada I
- Journal Title
  
  International Journal of Molecular Science
  
  Volume: 16 Issue: 10 Pages: 23604-23614
- DOI
  10.3390/ijms161023604
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K07687
[Journal Article] Gene expression profiling of white adipose tissue reveals paternal transmission of proneness to obesity.2015
- Author(s)
  Morita S, Nakabayashi K, Kawai T, Hayashi K, Horii T, Kimura M, Kamei Y, Ogawa Y, Hata K, Hatada I
- Journal Title
  
  Sci. Rep.
  
  Volume: 6 Issue: 1 Pages: 21693-21693
- DOI
  10.1038/srep21693
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25460409, KAKENHI-PROJECT-26560076, KAKENHI-PROJECT-15K14432, KAKENHI-PROJECT-25292076, KAKENHI-PROJECT-16H04926, KAKENHI-PROJECT-15K12669, KAKENHI-PROJECT-16K07194
[Journal Article] Validation of microinjection methods for generating knockout mice by CRISPR/Cas-mediated genome engineering2014
- Author(s)
  Horii T, Arai Y, Yamazaki M, Morita S, Kimura M, Itoh M, Abe Y, Hatada I
- Journal Title
  
  Sci Rep
  
  Volume: 4 Issue: 1 Pages: 4513-4513
- DOI
  10.1038/srep04513
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591816, KAKENHI-PROJECT-24613002
[Journal Article] Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System2013
- Author(s)
  Horii T, Tamura D, Morita S, Kimura M, Hatada I
- Journal Title
  
  Int J Mol Sci
  
  Volume: 14 Pages: 19774-19781
- Data Source
  KAKENHI-PROJECT-23616001
[Journal Article] Genome engineering of mammalian haploid embryonic stem cells using the cas9/RNA system2013
- Author(s)
  Horii T, Morita S, Kimura M, Kobayashi R, Tamura D, Takahashi RU, Kimura H, Suetake I, Ohata H, Okamoto K, Tajima S, Ochiya T, Abe Y, Hatada I
- Journal Title
  
  PeerJ
  
  Volume: 2013 Issue: 1 Pages: e230-e230
- DOI
  10.7717/peerj.230
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591816, KAKENHI-PUBLICLY-24116515, KAKENHI-PROJECT-24570153, KAKENHI-PROJECT-24613002, KAKENHI-PROJECT-25650007
[Journal Article] Generation of an ICF Syndrome Model by Efficient Genome Editing of Human Induced Pluripotent Stem Cells Using the CRISPR System.2013
- Author(s)
  Horii T, Tamura D, Morita S, Kimura M, , Hatada I
- Journal Title
  
  Int J Mol Sci
  
  Volume: 14 Issue: 10 Pages: 19774-19781
- DOI
  10.3390/ijms141019774
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23616001, KAKENHI-PROJECT-24613002
[Journal Article] Genome-Wide Analysis of DNA Methylation and Expression of MicroRNAs in Breast Cancer Cells.2012
- Author(s)
  Morita S, Takahashi RU, Yamashita R, Toyoda A, Horii T, Kimura M, Fujiyama A, Nakai K, Tajima S, Matoba R, Ochiya T, Hatada I.
- Journal Title
  
  Int J Mol Sci.
  
  Volume: 13 Pages: 8259-8272
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24613002
[Journal Article] The Dnmt3b Splice Variant is Specifically Expressed in In Vitro-manipulated Blastocysts and Their Derivative ES Cells2011
- Author(s)
  Horii T, Suetake I, Yanagisawa E, Morita S, Kimura M, Nagao Y, Imai H, Tajima S, Hatada I
- Journal Title
  
  J Reprod Dev
  
  Volume: 57 Pages: 579-585
- NAID
  10029878177
- Data Source
  KAKENHI-PROJECT-23616001
[Journal Article] The Dnmt3b splice variant is specifically expressed in in vitro-manipulated blastocysts and their derivative ES cells2011
- Author(s)
  Horii T, Suetake I, Yanagisawa E, Kimura M, Morita S, Nagao Y, Imai H, Tajima S, Hatada I.
- Journal Title
  
  J Reprod Dev
  
  Volume: 57 Pages: 579-585
- NAID
  10029878177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23616001
[Journal Article] Epigenetic Regulation of Adipocyte Differentiation by a Rho Guanine Nucleotide Exchange Factor, WGEF2009
- Author(s)
  Horii T, Morita S, Kimura M, Hatada I.
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Dicer is required for maintaining adult pancreas2009
- Author(s)
  Morita S, Hara A, Kojima I, Horii T, .Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Dicer is required for maintaining adult pancreas2009
- Author(s)
  Morita S, Hara A, Kojima I, Horii T, Kimura M, Kitamura T, Ochiya T, Nakanishi K, Matoba R, Matsubara K, Hatada I
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Epigenetic Regulation of Adipocyte Differentiation by a Rho Guanine Nucleotide Exchange Factor, WGEF.2009
- Author(s)
  Horii T, Morita S, Kimura M, Hatada I.
- Journal Title
  
  PLoS ONE 4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells.2008
- Author(s)
  Horii T, Kimura M, Morita S, Nagao Y & Hatada I.^*
- Journal Title
  
  Stem cells 26
  
  Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Mecp-2 dependent repression of an imprinted miR-184 released by depol arization.2008
- Author(s)
  Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S & Hatada I^*
- Journal Title
  
  Hum Mol Genet. 17
  
  Pages: 1192-1199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Geome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells2008
- Author(s)
  Hatada I,Morita S, Kimura M, Horii T, Yamashita R & Nakai K
- Journal Title
  
  J Hum Genet 53
  
  Pages: 185-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells.2008
- Author(s)
  Horii T, Kimura M, Morita S, Nagao Y & Hatada I.^*
- Journal Title
  
  Stem cells 26
  
  Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells2008
- Author(s)
  Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, MatsubaraK, K ato T, Ochiva T
- Journal Title
  
  FEBS J 275
  
  Pages: 1260-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells2008
- Author(s)
  Horii T, Kimura M, Morita S, Naeao Y & Hatada I
- Journal Title
  
  Stem cells 26
  
  Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Mecp-2 dependent repression of an imprinted miR-184 released by depolarization2008
- Author(s)
  Nomura T, Kimura lvi, Horii T, Morita S, Soejima H, Kudo S & Hatada I
- Journal Title
  
  Hum Mol Genet 17
  
  Pages: 1192-1199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Geome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells.2008
- Author(s)
  Hatada I^*, Morita S, Kimura M, Horii T, Yamashita R & Nakai K.
- Journal Title
  
  J. Hum Genet. 53
  
  Pages: 185-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Geome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells.2008
- Author(s)
  Hatada I^*, Morita S, Kimura M, Horii T, Yamashita R & Nakai K.
- Journal Title
  
  J. Hum Genet. 53
  
  Pages: 185-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells2008
- Author(s)
  Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T.
- Journal Title
  
  FEBS J 275
  
  Pages: 1260-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.2008
- Author(s)
  Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T.
- Journal Title
  
  FEBS J. 275
  
  Pages: 1260-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Astrocytespecific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation2008
- Author(s)
  Hatada I, Namihira M, Morita S, Kimura M, Horii T, Nakashima K
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Geome-wide demethylation during neural differentiation of P19 embryonal carcinoma cells2008
- Author(s)
  Hatada I, Morita S, Kimura M, Horii T, Yamashita R & Nakai K.
- Journal Title
  
  J. Hum Genet 53
  
  Pages: 185-191
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012009
[Journal Article] Loss of Genomic Imprinting in Mouse Parthenogenetic Embryonic Stem Cells2008
- Author(s)
  Horii T, Kimura M, Morita S, Nagao Y & Hatada I
- Journal Title
  
  Stem cells 26
  
  Pages: 79-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation2008
- Author(s)
  Hatada I, Namihira M, Morita S, Kimura M, Horii T, Nakashima K
- Journal Title
  
  PLoS ONE 3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] Mecp-2 dependent repression of an imprinted miR-184 released by depolarization2008
- Author(s)
  Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S & Hatada I
- Journal Title
  
  Hum Mol Genet 28
  
  Pages: 1192-1199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20016002
[Journal Article] A comparative analysis of the transcriptome and signal pathways in hepatic differentiation of human adipose mesenchymal stem cells.2008
- Author(s)
  Yamamoto Y, Banas A, Murata S, Ishikawa M, Lim CR, Teratani T, Hatada I, Matsubara K, Kato T, Ochiya T.
- Journal Title
  
  FEBS J. 275
  
  Pages: 1260-1273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Mecp-2 dependent repression of an imprinted miR-184 released by depolarization.2008
- Author(s)
  Nomura T, Kimura M, Horii T, Morita S, Soejima H, Kudo S & Hatada I^*
- Journal Title
  
  Hum Mol Genet. 17
  
  Pages: 1192-1199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] One Argonaute family member, Eif2c2 (Agog), is essential for development and appears not to be involved in DNA methylation.2007
- Author(s)
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T & Hatada I^*.
- Journal Title
  
  Genomics. 89
  
  Pages: 687-696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation2007
- Author(s)
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I
- Journal Title
  
  Genomics (in press)
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.2007
- Author(s)
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I
- Journal Title
  
  Genomics (in press)
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Long-Term Effects of In Vitro Growth of Mouse Oocytes on Their Maturation and Development.2007
- Author(s)
  Obata Y, Maeda Y, Hatada I & Kono^* T.
- Journal Title
  
  J Reprod Dev. 53
  
  Pages: 1183-1190
- NAID
  10020172629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.2007
- Author(s)
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T, Hatada I
- Journal Title
  
  Genomics (in press)
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Long-Term Effects of In Vitro Growth of Mouse Oocytes on Their Maturation and Development.2007
- Author(s)
  Obata Y, Maeda Y, Hatada I & Kono^* T.
- Journal Title
  
  J Reprod Dev. 53
  
  Pages: 1183-1190
- NAID
  10020172629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Long-term effects of in vitro growth of mouse oocytes on their maturation and development.2007
- Author(s)
  Obata Y., Maeda Y., Hatada I., and Kono T.
- Journal Title
  
  J Reprod Dev. 53
  
  Pages: 1183-1190
- NAID
  10020172629
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] One Argonaute family member, Eif2c2 (Ago2), is essential for development and appears not to be involved in DNA methylation.2007
- Author(s)
  Morita S, Horii T, Kimura M, Goto Y, Ochiya T & Hatada I^*.
- Journal Title
  
  Genomics. 89
  
  Pages: 687-696
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Emerging Technologies for Genome-wide DNA Methylation Profiling in Cancer.2006
- Author(s)
  Hatada I
- Journal Title
  
  Crit Rev Oncog. 12(3-4)
  
  Pages: 205-223
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Microarray analysis of promoter methylation in lung cancers.2006
- Author(s)
  Fukasawa, M., Kimura, M., Morita, S., Hatada, I., et al.
- Journal Title
  
  J Hum Genet. (in press)
- NAID
  10017479946
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] Genomic imprinting in Dicerl-hypomorphic mice.2006
- Author(s)
  Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I
- Journal Title
  
  Cytogenet Genome Res. 113(1-4)
  
  Pages: 138-143
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Genome-wide profiling of promoter methylation in human.2006
- Author(s)
  Hatada, I., Fukasawa, M., Kimura, M., Morita, S., Yamada, K., et al.
- Journal Title
  
  Oncogene (in press)
- NAID
  120000908395
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] Genomic imprinting in Dicerl-hypomorphic mouse.2006
- Author(s)
  Fukasawa, M., Morita, S., Kimura, M., Hatada, I., et al.
- Journal Title
  
  Cytogenet Genome Res. 113
  
  Pages: 138-143
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] Emerging Technologies for Genome-wide DNA Methylation Profiling in Cancer.2006
- Author(s)
  Hatada I
- Journal Title
  
  Crit Rev Oncog. 12(3-4)
  
  Pages: 205-223
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Genomic imprinting in Dicerl-hypomorphic mice.2006
- Author(s)
  Fukasawa M, Morita S, Kimura M, Horii T, Ochiya T, Hatada I
- Journal Title
  
  Cytogenet Genome Res. 113(1-4)
  
  Pages: 138-143
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Genome-wide profiling of promoter methylation in human.2006
- Author(s)
  Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H
- Journal Title
  
  Oncogene 25(21)
  
  Pages: 3059-3064
- NAID
  120000908395
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Microarray analysis of promoter methylation in lung cancers.2006
- Author(s)
  Fukasawa M, Kimura M, Morita S, Matsubara K, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Sasaki H, Hatada I
- Journal Title
  
  J Hum Genet. 51(4)
  
  Pages: 368-374
- NAID
  10017479946
- Data Source
  KAKENHI-PROJECT-18012010
[Journal Article] Genome-wide profiling of promoter methylation in human.2006
- Author(s)
  Hatada I, Fukasawa M, Kimura M, Morita S, Yamada K, Yoshikawa T, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Ushijima T, Sasaki H
- Journal Title
  
  Oncogene 25(21)
  
  Pages: 3059-3064
- NAID
  120000908395
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Emerging Technologies for Genome-wide DNA Methylation Profiling in Cancer2006
- Author(s)
  Hatada I.
- Journal Title
  
  Crit Rev Oncog 12
  
  Pages: 205-223
- Data Source
  KAKENHI-PROJECT-15080201
[Journal Article] Microarray analysis of promoter methylation in lung cancers.2006
- Author(s)
  Fukasawa M, Kimura M, Morita S, Matsubara K, Yamanaka S, Endo C, Sakurada A, Sato M, Kondo T, Horii A, Sasaki H, Hatada I
- Journal Title
  
  J Hum Genet. 51(4)
  
  Pages: 368-374
- NAID
  10017479946
- Data Source
  KAKENHI-PROJECT-18016003
[Journal Article] Normal Reprogramming of Imprinting in Parthenogenetic Female Germ Cells2005
- Author(s)
  Horii, T., Nagao, Y., Kimura, M., Hatada, I.
- Journal Title
  
  Reprod Fetil Dev 17
  
  Pages: 236-236
- Data Source
  KAKENHI-PROJECT-15080201
[Patent] ゲノムDNAのメチル化検出方法2004
- Inventor(s)
  畑田出穂
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-226103
- Filing Date
  2004-08-02
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15370092
[Patent] ゲノムDNAのメチル化検出方法2002
- Inventor(s)
  畑田出穂
- Industrial Property Rights Holder
  群馬大学
- Industrial Property Number
  2004-226103
- Filing Date
  2002-08-02
- Data Source
  KAKENHI-PROJECT-16011205
[Presentation] ヒト子宮内膜がん細胞におけるKMT2変異の意義2022
- Author(s)
  小林良祐、川端麗香、杉山真言、横堀武彦、森田純代、堀居拓郎、西山正彦、畑田出穂
- Organizer
  第15回日本エピジェネティクス研究会年会
- Data Source
  KAKENHI-PROJECT-20H03431
[Presentation] ゲノム編集、エピゲノム編集によるモデルマウスの新展開2019
- Author(s)
  畑田出穂
- Organizer
  第40回日本炎症・再生医学会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03613
[Presentation] エピゲノム研究の新展開2019
- Author(s)
  畑田出穂
- Organizer
  日本ゲノム編集学会第4回大会
- Invited
- Data Source
  KAKENHI-PROJECT-17H03613
[Presentation] ゲノム編集からエピゲノム編集まで2019
- Author(s)
  畑田出穂
- Organizer
  第３０回日本医学会総会2019中部
- Invited
- Data Source
  KAKENHI-PROJECT-17H03613
[Presentation] Epigenome and genome editing of mammals2018
- Author(s)
  Hatada i
- Organizer
  Genome Editing Towards Medicinal Applications
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03613
[Presentation] Epigenome and genome editing of mammals2018
- Author(s)
  畑田出穂
- Organizer
  第9回武田科学振興財団薬科学シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H03613
[Presentation] エピゲノム編集：特定のDNAメチル化領域を効率よく操作する方法の開発2018
- Author(s)
  森田純代、堀居拓郎、木村美香、畑田出穂
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-16K07194
[Presentation] Lox配列の２ステップ導入による効率的なコンディショナルノックアウトマウスの作製2017
- Author(s)
  堀居拓郎、森田純代、木村美香、寺脇直美、渋谷海大、畑田出穂
- Organizer
  日本分子生物学会
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] 父性遺伝する食事誘導性肥満におけるインプリント遺伝子の解析と新規インプリント遺伝子の探索について2016
- Author(s)
  森田純代、中林一彦、河合智子、林恵子、堀居拓郎、木村美香、、亀井康富、小川佳宏、秦健一郎、畑田出穂
- Organizer
  日本エピジェネティックス研究会第10回年会
- Place of Presentation
  千里ライフサイエンスセンター
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16K07194
[Presentation] Cas9タンパクおよびエレクトロポレーション法を用いたコンディショナルノックアウトマウスの作製2016
- Author(s)
  堀居拓郎、森田純代、木村美香、寺脇直美、畑田出穂
- Organizer
  第1回日本ゲノム編集学会
- Place of Presentation
  広島
- Year and Date
  2016-09-06
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] ES細胞の多能性にはTetによるNr2f2プロモーター領域の脱メチル化が必要であ2016
- Author(s)
  堀居拓郎、森田純代、木村美香、寺脇直美、木村博信、末武勲、田嶋正二、安部由美子、畑田出穂
- Organizer
  第10回日本エピジェネティクス研究会年会
- Place of Presentation
  大阪
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] Tetタンパクは転写因子Nr2f2のプロモーターを脱メチル化することによりES細胞の多能性を維持する2016
- Author(s)
  堀居拓郎、森田純代、木村美香、寺脇直美、木村博信、末武勲、田嶋正二、安部由美子、畑田出穂
- Organizer
  第109回日本繁殖生物学会年会
- Place of Presentation
  相模原
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] ES細胞の初期分化にはTetによるNr2f2プロモーター領域の脱メチル化が必要である2015
- Author(s)
  堀居拓郎、森田純代、木村美香、小林遼平、田村大樹、木村博信、末武勲、田嶋正二、安部由美子、畑田出穂
- Organizer
  第9回日本エピジェネティクス研究会年会
- Place of Presentation
  学術総合センター一橋講堂（東京都千代田区）
- Year and Date
  2015-05-25
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] Tet遺伝子シングル、ダブルおよびトリプルノックアウトES細胞株の特性2015
- Author(s)
  堀居拓郎、森田純代、木村美香、小林遼平、田村大樹、木村博信、末武勲、田嶋正二、安部由美子、畑田出穂
- Organizer
  第38回日本分子生物学会年会
- Place of Presentation
  神戸国際展示場（兵庫県神戸市）
- Year and Date
  2015-12-01
- Data Source
  KAKENHI-PROJECT-15K07687
[Presentation] ミトコンドリアにおける翻訳停滞解消機構の解明2015
- Author(s)
  村里旺彦，小暮裕幸，堀居拓郎，浅川直紀，畑田出穂，行木信一
- Organizer
  平成27年度日本生化学会関東支部例会
- Place of Presentation
  新潟日報メディアシップ（新潟県）
- Year and Date
  2015-06-20
- Data Source
  KAKENHI-PROJECT-15K06945
[Presentation] Stalled-ribosome rescue factors are essential for mitochondrial function.2015
- Author(s)
  Shizuka Kobayasi, Akihiko Murasato, Sho Arai, Hiroyuki Kogure, Takuro Horii, Izuho Hatada and Nobukazu Nameki
- Organizer
  2nd International Symposium of Gunma University Medical Innovation (GUMI2015)
- Place of Presentation
  群馬大学昭和キャンパス（群馬県）
- Year and Date
  2015-12-08
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K06945
[Presentation] 半数体ES細胞とCRISPR/Casを用いた高効率ゲノム編集2013
- Author(s)
  堀居拓郎，森田純代，木村美香，小林遼平，田村大樹，高橋陵宇，木村博信，末武勲，大畑広和，岡本康司，田嶋正二，落谷孝広，安部由美子，畑田出穂
- Organizer
  ゲノム編集研究会
- Place of Presentation
  東広島
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] 半数体胚由来２倍体ES細胞の移植医療への利用の可能性2013
- Author(s)
  堀居拓郎、小林遼平、田村大樹、森田純代、木村美香、畑田出穂
- Organizer
  日本エピジェネティクス研究会
- Place of Presentation
  奈良
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] 低酸素培養は初期胚や胎盤にDNAメチル化異常を引き起こす2012
- Author(s)
  堀居拓郎、柳澤永吉、森田純代、木村美香、畑田出穂
- Organizer
  第６回日本エピジェネティクス研究会年会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] Risk of Epigenetic Changes is Increased by Low Oxygen in ART Embryo Cultures2012
- Author(s)
  堀居拓郎、柳澤永吉、森田純代、木村美香、畑田出穂
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] 初期胚の低酸素培養は初期胚や胎盤にDNAメチル化異常を引き起こす2012
- Author(s)
  堀居拓郎、柳澤永吉、森田純代、木村美香、畑田出穂
- Organizer
  第105回日本繁殖生物学会年会
- Place of Presentation
  つくば
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] Profiling and characterization of DNA methylation targets2009
- Author(s)
  Hatada I
- Organizer
  JapanDenmark Joint Workshop on "Molecular Cancer Research"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20016002
[Presentation] Profiling and characterization of DNA methylation targets2009
- Author(s)
  Hatada I
- Organizer
  Japan-Denmark Joint Workshop on "Molecular Cancer Research"
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20012009
[Presentation] Development of genome-wide DNA methylation analysis method and applications2009
- Author(s)
  Hatada I
- Organizer
  68^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-20012009
[Presentation] Development of genome-wide DNA methylation analysis method and applications2009
- Author(s)
  Hatada I
- Organizer
  68^<th> Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama, Japan
- Data Source
  KAKENHI-PROJECT-20016002
[Presentation] Profiling of DNA methylation targets2008
- Author(s)
  Hatada I
- Organizer
  Decoding Epigenetic Code
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20012009
[Presentation] Profiling of DNA methylation targets2008
- Author(s)
  Hatada I
- Organizer
  Decoding Epigenetic Code
- Place of Presentation
  Tokyo
- Data Source
  KAKENHI-PROJECT-20016002
[Presentation] Genome-wide DNA methyaltion analysis by MIAMI.2007
- Author(s)
  Hatada I^*
- Organizer
  Epigenomics, Technology, Products, and Obstacles
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-18016003
[Presentation] Genome-wide DNA methyaltion analysis by MIAMI.2007
- Author(s)
  Hatada I^*
- Organizer
  Epigenomics, Technology, Products, and Obstacles
- Place of Presentation
  Osaka, Japan
- Year and Date
  2007-06-14
- Data Source
  KAKENHI-PROJECT-18012010
[Presentation] CRISPR/Cas9システムによる哺乳類半数体ES 細胞のゲノム操作
- Author(s)
  堀居拓郎，森田純代，木村美香，小林遼平，田村大樹，高橋陵宇，木村博信，末武勲，大畑広和，岡本康司，田嶋正二，落谷孝広，安部由美子，畑田出穂
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] CRISPR/Casと半数体ES細胞を用いたトリプルノックアウトおよび大規模染色体欠失の作製
- Author(s)
  堀居拓郎，森田純代，木村美香，高橋陵宇，木村博信，末武勲，田嶋正二，落谷孝広，畑田出穂
- Organizer
  日本繁殖生物学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-24613002
[Presentation] 半数体胚由来２倍体ES 細胞(hddES)- 再生医療における新たな多能性幹細胞の選択肢
- Author(s)
  小林遼平，堀居拓郎，田村大樹，森田純代，木村美香，安部由美子，畑田出穂
- Organizer
  日本分子生物学会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-24613002

1. HORII Takuro (00361387)

# of Collaborated Projects: 14 results

# of Collaborated Products: 58 results
2. Morita Sumiyo (40589264)

# of Collaborated Projects: 7 results

# of Collaborated Products: 9 results
3. OBATA Yayoi (70312907)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. 落谷孝広 (60192530)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
5. 小林良祐 (30802855)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. 川端麗香 (90721928)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
7. 横堀武彦 (60420098)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. 堀井明 (40249983)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
9. 調憲 (70264025)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. 川辺浩志 (00582454)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. 六本木麗子 (80719857)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. Nohara Keiko (50160271)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. Nakabayashi Kazuhiko (10415557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
14. Suzuki Takehiro (60425494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. Okamura Kazuyuki (50736064)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. KONO Tomohiro (80153485)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. MIYANO Takashi (80200195)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. Nameki Nobukazu (80302959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
19. 中井謙太 (60217643)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
20. 秦健一郎 (60360335)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 澁谷海大 (70786839)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 西山正彦 (20198526)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
23. 大日方英 (50332557)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 安部由美子 (70261857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
25. 河野大輔 (10382904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 中尾章人 (30748926)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. 平井宏和 (70291086)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. Turtoi Andrei (60787141)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. 佐伯浩司 (80325448)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. Matsushita Junya

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. 末武勲

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
32. 田嶋正二

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hatada Izuho 畑田 出穂

HATADA Izuho 畑田 出穂

畑田 出穂 ハタダ イズホ

Research Projects

Research Products

Co-Researchers

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Innovative Combination Immunotherapy Targets Vulnerability of KMT2 Mutant Uterine CancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Histone methyltransferase KMT2 mutation-induced epigenomic abnormalities and endometrial cancer development and progressionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

A new therapeutic strategy for autoimmune diseases through epigenome editingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Is pseudogene fake?Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Hatada Izuho 畑田出穂

HATADA Izuho 畑田出穂

畑田出穂ハタダイズホ