Shinkuma Satoru 新熊悟

… Alternative Names

SHINKUMA Satoru 新熊悟

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Researcher Number	00613788
Other IDs
Affiliation (Current)	2025: 奈良県立医科大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 奈良県立医科大学, 医学部, 准教授 2017 – 2019: 新潟大学, 医歯学系, 准教授 2015 – 2016: 北海道大学, 大学病院, 助教 2015: 北海道大学, 医学(系)研究科(研究院), 助教 2014: 北海道大学, 医学(系)研究科(研究院), その他 … More 2014: 北海道大学, 大学院医学研究科, 助教 2012 – 2013: 北海道大学, 医学(系)研究科(研究院), 助教 2011 – 2012: 北海道大学, 大学院・医学研究科, 助教 Less
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Medium-sized Section 53:Organ-based internal medicine and related fields
Keywords	Principal Investigator 表皮水疱症 / CRISPR/Cas9 / 遺伝子編集 / 細胞競合 / 再生医療 / 7型コラーゲン / 相同組換え / 復帰変異モザイク / 皮膚科学 / フレームシフト変異 … More / iPS細胞 / 遺伝子治療 / reframing治療 / 遺伝性皮膚疾患 / モデルマウス / モザイク病変 / 電子顕微鏡学的検査 / 免疫組織学的検査 / 遺伝子変異検索 … More Except Principal Investigator 持続感染 / HHV-6 / DIHS / 薬剤性過敏症症候群 / モデルマウス / 表皮水疱症 / 皮膚病態学 / NK細胞 / シングルセルRNA-seq解析 / 再活性化 / 自己免疫疾患 / ヒトヘルペスウイルス / 感受性遺伝子 / 薬疹 / 中毒性表皮壊死症 / Stevens-Johnson症候群 / 細胞死 / 重症薬疹 / 皮膚科学 / 染色体組換え / CRISPR/Cas9 / 遺伝子治療 / 遺伝子編集 / 細胞療法 / 17型コラーゲン / 復帰変異モザイク / 7型コラーゲン / グリシン置換変異 / ドミナントネガティブ効果 / 皮膚生理学 / 自己免疫 / 酵素 / 細胞・組織 / タンパク質 / 生体分子 / 皮膚病理学 Less

X染色体不活性化機構を応用したモザイクマウスを用いた細胞増殖優位性獲得機序の解明Principal Investigator
- Principal Investigator
  
  新熊悟
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Nara Medical University
Elucidation of the elimination mechanism of HHV-6 infected cells with a focus on NK cells in DIHS
- Principal Investigator
  
  浅田秀夫
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Nara Medical University
Elucidation of the mechanism for revertant mosaicism using model micePrincipal Investigator
- Principal Investigator
  
  Shinkuma Satoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Nara Medical University
Elucidation of the pathogenic mechanism of autoimmune diseases focusing on HHV-6 persistent infection in DIHS
- Principal Investigator
  
  Hideo Asada
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Nara Medical University
Elucidation of specific cell death mechanism and biomarker search in severe drug eruption
- Principal Investigator
  
  Riichiro Abe
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Niigata University
Establishment of epidermolysis bullosa model mouse with revertant mosaicism and its treatment
- Principal Investigator
  
  Shimizu Hiroshi
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Regenerative therapy using gene-edited iPS cells derived from an epidermolysis bullosa patientPrincipal Investigator
- Principal Investigator
  
  Shinkuma Satoru
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Niigata University
Generation of model mice using CRISPR/Cas9Principal Investigator
- Principal Investigator
  
  Shinkuma Satoru
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Niigata University
  Hokkaido University
遺伝子編集技術を用いた表皮水疱症の多角的再生医療の開発Principal Investigator
- Principal Investigator
  
  新熊悟
- Project Period (FY)
  2015
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Production of a novel blistering disease model by regulating expression of collagen XVII
- Principal Investigator
  
  Nishie Wataru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Pathogenic roles of collagen XVII in migration of basal keratinocytes
- Principal Investigator
  
  ITO Kei
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
Generation of dominant dystrophic epidermolysis bullosa model mice using humanized COL7 mice
- Principal Investigator
  
  SHIMIZU Hiroshi
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University
New insight into genotype-phenotype correlation in recessive dystrophic epidermolysis bullosaPrincipal Investigator
- Principal Investigator
  
  SHINKUMA Satoru
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Dermatology
- Research Institution
  Hokkaido University

All 2023 2022 2021 2020 2019 2018 2017 2016 2013 2012 Other

All Journal Article Presentation

[Journal Article] 2．表皮水疱症でみられる復帰変異モザイク2023
- Author(s)
  新熊悟
- Journal Title
  
  The Japanese Journal of Dermatology
  
  Volume: 133 Issue: 13 Pages: 3065-3073
- DOI
  10.14924/dermatol.133.3065
- ISSN
  0021-499X, 1346-8146
- Year and Date
  2023-12-20
- Language
  Japanese
- Data Source
  KAKENHI-PROJECT-21H02943
[Journal Article] Possible relation of cathepsin C activity and seasonal fluctuation of skin lesions in Papillon?Lef?vre syndrome2023
- Author(s)
  Sakai Akari、Shinkuma Satoru、Miura Nobuaki、Deguchi Tokiko、Oginezawa Mahoko、Nakajima Mami、Katsumi Tatsuya、Hayashi Ryota、Abe Riichiro
- Journal Title
  
  British Journal of Dermatology
  
  Volume: 190 Issue: 2 Pages: 272-274
- DOI
  10.1093/bjd/ljad373
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02943
[Journal Article] New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa2022
- Author(s)
  Nguyen Hong Ha、Shinkuma Satoru、Hayashi Ryota、Katsumi Tatsuya、Nishiguchi Tomoki、Natsuga Ken、Fujita Yasuyuki、Abe Riichiro
- Journal Title
  
  Journal of Cutaneous Immunology and Allergy
  
  Volume: 5 Issue: 3 Pages: 78-87
- DOI
  10.1002/cia2.12230
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21H02943
[Journal Article] Serum Soluble OX40 as a Diagnostic and Prognostic Biomarker for Drug-Induced Hypersensitivity Syndrome/Drug Reaction with Eosinophilia and Systemic Symptoms2022
- Author(s)
  Mitsui Y, Shinkuma S, Nakamura-Nishimura Y, Ommori R, Ogawa K, Miyagawa F, Mori Y, Tohyama M, Asada H
- Journal Title
  
  J Allergy Clin Immunol Pract
  
  Volume: 10 Issue: 2 Pages: 585-565
- DOI
  10.1016/j.jaip.2021.10.042
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K08797, KAKENHI-PROJECT-19K17811, KAKENHI-PROJECT-20K17357, KAKENHI-PROJECT-21K08306
[Journal Article] Advances in gene therapy and their application to skin diseases: A review2021
- Author(s)
  Shinkuma Satoru
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 103 Issue: 1 Pages: 2-9
- DOI
  10.1016/j.jdermsci.2021.05.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21H02943
[Journal Article] Current topics in Epidermolysis bullosa: Pathophysiology and therapeutic challenges.2021
- Author(s)
  Natsuga K, Shinkuma S, Hsu CK, Fujita Y, Ishiko A, Tamai K, McGrath JA
- Journal Title
  
  J Dermatol Sci
  
  Volume: 104(3) Issue: 3 Pages: 164-176
- DOI
  10.1016/j.jdermsci.2021.11.004
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19H03682, KAKENHI-PROJECT-21H02943
[Journal Article] RIP3 as a diagnostic and severity marker for Stevens-Johnson syndrome and toxic epidermal necrolysis2020
- Author(s)
  Hasegawa Akito、Shinkuma Satoru、Hayashi Ryota、Hama Natsumi、Watanabe Hideaki、Kinoshita Manao、Ogawa Youichi、Abe Riichiro
- Journal Title
  
  The Journal of Allergy and Clinical Immunology: In Practice
  
  Volume: 8 Issue: 5 Pages: 1768-1771
- DOI
  10.1016/j.jaip.2020.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H04047, KAKENHI-PROJECT-18K16022
[Journal Article] Functional analysis of keratin filament network formation indicates clinical severity of epidermolysis bullosa simplex.2020
- Author(s)
  Ansai O, Shinkuma S, Hayashi R, Tomii K, Deguchi T, Aizawa A, Fujiwara H, Shimomura Y, Abe R.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: i n press Issue: 10
- DOI
  10.1111/jdv.16495
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05089
[Journal Article] Efficient gene reframing therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas92019
- Author(s)
  Takashima Shota、Shinkuma Satoru、Fujita Yasuyuki、Nomura Toshifumi、Ujiie Hideyuki、Natsuga Ken、Iwata Hiroaki、Nakamura Hideki、Vorobyev Artem、Abe Riichiro、Shimizu Hiroshi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: in press Issue: 8 Pages: 1711-1721
- DOI
  10.1016/j.jid.2019.02.015
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089, KAKENHI-PROJECT-16K10120, KAKENHI-PROJECT-19K08764, KAKENHI-PROJECT-17H01572
[Journal Article] Amino acid charge and epidermolysis bullosa simplex severity: genotype‐phenotype correlations2019
- Author(s)
  Ansai O.、Shinkuma S.、Kabata Y.、Katsumi T.、Hagiwara R.、Tomii K.、Fujikawa H.、Matsubara M.、Abe R.
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: 34 Issue: 2
- DOI
  10.1111/jdv.15990
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H05089
[Journal Article] Electron Microscopic and Immunohistochemical Findings of the Epidermal Basement Membrane in Two Families with Nail-patella Syndrome2019
- Author(s)
  Shinkuma S、Nakamura H、Maehara M、Takashima S、Nomura T、Fujita Y、Hasegawa S、Sato-Matsumura K、Abe R、Shimizu H
- Journal Title
  
  Acta Dermato Venereologica
  
  Volume: 99(12) Pages: 1110-1115
- DOI
  10.2340/00015555-3318
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08764, KAKENHI-PROJECT-17H01572, KAKENHI-PROJECT-17H05089
[Journal Article] Novel COL7A1 mutation in a family with bullous dermolysis of the newborn: Phenotypic variability associated with a COL7A1 mutation within the same family2018
- Author(s)
  Takashima Shota、Shinkuma Satoru、Fujita Yasuyuki、Natsuga Ken、Nomura Toshifumi、Hida Tokimasa、Ishikawa Shuku、Nakamura Hideki、Abe Riichiro、Shimizu Hiroshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 印刷中 Issue: 9
- DOI
  10.1111/1346-8138.14287
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K15540, KAKENHI-PROJECT-18K19531, KAKENHI-PROJECT-17H05089, KAKENHI-PROJECT-17K16317
[Journal Article] Establishment of integration-free induced pluripotent stem cells from human recessive dystrophic epidermolysis bullosa keratinocytes2018
- Author(s)
  Matsumura Wakana、Fujita Yasuyuki、Nakayama Chihiro、Shinkuma Satoru、Suzuki Shotaro、Nomura Toshifumi、Abe Riichiro、Shimizu Hiroshi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 89 Issue: 3 Pages: 263-271
- DOI
  10.1016/j.jdermsci.2017.11.017
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089, KAKENHI-PROJECT-15K09753, KAKENHI-PROJECT-17H01572
[Journal Article] Epidermal aspects of type VII collagen: Implications for dystrophic epidermolysis bullosa and epidermolysis bullosa acquisita2018
- Author(s)
  Watanabe Mika、Natsuga Ken、Shinkuma Satoru、Shimizu Hiroshi
- Journal Title
  
  The Journal of Dermatology
  
  Volume: 45 Issue: 5 Pages: 515-521
- DOI
  10.1111/1346-8138.14222
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H01572, KAKENHI-PROJECT-17H05089, KAKENHI-PROJECT-17K16317
[Journal Article] The development of induced pluripotent stem cell-derived mesenchymal stem/stromal cells from normal human and RDEB epidermal keratinocytes2018
- Author(s)
  Nakayama Chihiro、Fujita Yasuyuki、Matsumura Wakana、Ujiie Inkin、Takashima Shota、Shinkuma Satoru、Nomura Toshifumi、Abe Riichiro、Shimizu Hiroshi
- Journal Title
  
  Journal of Dermatological Science
  
  Volume: 91 Issue: 3 Pages: 301-310
- DOI
  10.1016/j.jdermsci.2018.06.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K19531, KAKENHI-PROJECT-17H01572, KAKENHI-PROJECT-17H05089
[Journal Article] A case of recessive dystrophic epidermolysis bullosa with a novel c.6885_6898del14 mutation in the COL7A1 gene2017
- Author(s)
  Shinkuma S, Masunaga T, Miyawaki S, Takashima S, Natsuga K, Nomura T, Fujita Y, Nakamura H, Shimizu H
- Journal Title
  
  J Dermatol Sci
  
  Volume: 88 Issue: 1 Pages: 139-141
- DOI
  10.1016/j.jdermsci.2017.03.022
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10120, KAKENHI-PROJECT-17K16317, KAKENHI-PROJECT-16K15540
[Journal Article] The first familial cases of epidermolysis bullosa simplex, generalized severe with p.Asn176Ser in KRT5 revealing the clinical chronology2017
- Author(s)
  Sugai T, Shinkuma S, Inafuku K, Takashima S, Nomura T, Fujita Y, Nakamura H, Shimizu H
- Journal Title
  
  Journal of the European Academy of Dermatology and Venereology
  
  Volume: in press Issue: 5
- DOI
  10.1111/jdv.14036
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K15540, KAKENHI-PROJECT-16K10120
[Journal Article] Extracellular cleavage of collagen XVII is essential for correct cutaneous basement membrane formation.2016
- Author(s)
  Nishimura M, Nishie W, Shirafuji Y, Shinkuma S, Natsuga K, Nakamura H, Sawamura D, Iwatsuki K, Shimizu H
- Journal Title
  
  Hum Mol Genet
  
  Volume: 15;25(2) Issue: 2 Pages: 328-39
- DOI
  10.1093/hmg/ddv478
- NAID
  120005868259
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25461661, KAKENHI-PROJECT-15K15409, KAKENHI-PROJECT-24390274, KAKENHI-PROJECT-26293254, KAKENHI-PROJECT-15K19668, KAKENHI-PROJECT-16K10120, KAKENHI-PROJECT-15KK0289
[Journal Article] Jacyk、Ken Natsuga、Hideyuki Ujiie、Hideki Nakamura、Masashi Akiyama、Hiroshi Shimizu2013
- Author(s)
  Satoru Shinkuma、Wataru Nishie、 Witold K
- Journal Title
  
  A Novel Keratin 5 Mutation in an African Family with Epidermolysis Bullosa Simplex Indicates the Importance of the Amino Acid Located at the Boundary Site Between the H1 and Coil 1A Domains
  
  Volume: 印刷中 Issue: 5 Pages: 585-587
- DOI
  10.2340/00015555-1538
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890006, KAKENHI-PROJECT-24249062, KAKENHI-PROJECT-24659516, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-25670494
[Journal Article] A Novel Keratin 5 Mutation in an African Family with Epidermolysis Bullosa Simplex Indicates the Importance of the Amino Acid Located at the Boundary Site Between the H1 and Coil 1A Domains2013
- Author(s)
  Shinkuma S, Nishie W, Jacyk WK, Natsuga K, Ujiie H, Nakamura H, Akiyama M, Shimizu H.
- Journal Title
  
  Acta Dermato-Venereologica
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890006
[Journal Article] Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa2013
- Author(s)
  Shinkuma S, Sawamura D, Fujita Y, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
- Journal Title
  
  Acta Dermato-Venereologica
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890006
[Journal Article] Long-term Follow-up of Cultured Epidermal Autograft in a Patient with Recessive Dystrophic Epidermolysis Bullosa2013
- Author(s)
  Shinkuma S, Sawamura D, Fujita Y, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
- Journal Title
  
  Acta Dermato-Venereologica
  
  Volume: In press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659516
[Journal Article] Type VII collagen deficiency causesdefective tooth enamel formation due to poor differentiation of ameloblasts2012
- Author(s)
  Umemoto H, Akiyama M, Domon T, Nomura T, Shinkuma S, Ito K, Asaka T, Sawamura D, Uitto J, Uo M, Kitagawa Y, Shimizu H
- Journal Title
  
  Am J Pathol
  
  Volume: 181 Issue: 5 Pages: 1659-71
- DOI
  10.1016/j.ajpath.2012.07.018
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591215, KAKENHI-PROJECT-23390279, KAKENHI-PROJECT-23659546, KAKENHI-PROJECT-23791245, KAKENHI-PROJECT-23890006, KAKENHI-PROJECT-24249062, KAKENHI-PROJECT-24659516, KAKENHI-PROJECT-24659526, KAKENHI-PROJECT-24890008
[Journal Article] Long-term follow-up of cultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient
- Author(s)
  Satoru Shinkuma、Daisuke Sawamura、Yasuyuki Fujita、Hiroyuki Kawasaki、 Hiroyuki Nakamura、Masukazu Inoie、ataru Nishie、Hiroshi Shimizu
- Journal Title
  
  Acta Dermato-Venereologica
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23890006
[Journal Article] Long-term follow-up of cultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient
- Author(s)
  Satoru Shinkuma、Daisuke Sawamura、Yasuyuki Fujita、Hiroyuki Kawasaki、Hiroyuki Nakamura、Masukazu Inoie、ataru Nishie、Hiroshi Shimizu
- Journal Title
  
  Acta Dermato-Venereologica
  
  Volume: (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659516
[Presentation] SCFを介したメラノサイトと表皮角化細胞の細胞間相互作用2023
- Author(s)
  新熊　悟
- Organizer
  第5回日本白斑学会学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02943
[Presentation] 復帰変異モザイクを用いた自家培養表皮による表皮水疱症の治療と復帰変異モデルマウスの作製2023
- Author(s)
  新熊　悟
- Organizer
  第19回加齢皮膚医学研究会　再生医療のシンポジウム
- Invited
- Data Source
  KAKENHI-PROJECT-21H02943
[Presentation] Combination of TARC and soluble OX40 in the diagnosis of DIHS/DRESS.2022
- Author(s)
  Mitsui Y, Shinkuma S, Nakamura-Nishimura Y, Ommori R, Ogawa K, Miyagawa F, Asada H
- Organizer
  日本研究皮膚科学会
- Data Source
  KAKENHI-PROJECT-21K08306
[Presentation] New insight of itch mediators and proinflammatory cytokines in epidermolysis bullosa2022
- Author(s)
  Hong Ha Nguyen, Satoru Shinkuma, Ryota Hayashi, Tatsuya Katsumi, Tomoki Nishiguchi, Ken Natsuga, Yasuyuki Fujita, Riichiro Abe
- Organizer
  Society of Investigative Dermatology annual meeting 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02943
[Presentation] Persistent HHV-6 infection has an increased risk of autoimmune disorders in patients with DIHS.2021
- Author(s)
  Nishimura Y, Shobatake C, Miyagawa F, Shinkuma S, Watanabe H, Kira M, Nakajima S, Higashi Y, Asada H
- Organizer
  The 46th annual meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-21K08306
[Presentation] Cutaneous adverse events caused by EGFR inhibitors may result from reduced expression of human β-defensins induced by staphylococci.2021
- Author(s)
  Ommori R, Nishimura Y, Miyagawa F, Shobatake C, Ogawa K, Shinkuma S, Asada H
- Organizer
  The 46th annual meeting of the Japanese Society for Investigative Dermatology
- Data Source
  KAKENHI-PROJECT-21K08306
[Presentation] モザイク病変と遺伝性皮膚疾患2021
- Author(s)
  新熊　悟
- Organizer
  第72回　日本皮膚科学会中部支部学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21H02943
[Presentation] Exploring the possibilities of genome editing therapy for dystrophic epidermolysis bullosa via non-homologous end-joining pathway2019
- Author(s)
  Satoru Shinkuma
- Organizer
  The 4th Annual Meeting of Chinese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089
[Presentation] Frameshift mutations in different exons of Col17a1 lead to distinctive phenotype of junctional epidermolysis bullosa model mice2019
- Author(s)
  Hong Ha Nguyen, Satoru Shinkuma, Osamu Ansai, Yudai Kabata, Shota Takashima, Masashi Mori, Masahito Ikawa, Hiroshi Shimizu, Riichiro Abe
- Organizer
  The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089
[Presentation] Frameshift mutations in different exons of Col17a1 lead to distinctive phenotype of junctional epidermolysis bullosa model mice.2019
- Author(s)
  Nguyen Hong Ha, Shinkuma Satoru, Ansai Osamu, Kabata Yudai, Takashima Shota, Mori Masashi, Ikawa Masahito, Shimizu Hiroshi, Abe Riichiro
- Organizer
  The 44th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01572
[Presentation] Efficient reframed gene therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9.2018
- Author(s)
  Shota Takashima, Satoru Shinkuma, Yasuyuki Fujita, Toshifumi Nomura, Hideki Nakamura, Hiroshi Shimizu
- Organizer
  The 7th International Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089
[Presentation] Efficient reframed gene therapy for recessive dystrophic epidermolysis bullosa using CRISPR/Cas9.2018
- Author(s)
  Shota Takashima, Satoru Shinkuma, Yasuyuki Fujita, Toshifumi Nomura, Hideki Nakamura, Hiroshi Shimizu
- Organizer
  The 7th International Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01572
[Presentation] The development of mesenchymal stem/stromal cells from keratinocyte-derived induced pluripotent stem cells (iPSCs)2017
- Author(s)
  Chihiro Nakayama, Yasuyuki Fujita, Wakana Matsumura, Shota Takashima, Satoru Shinkuma, Toshifumi Nomura, Riichiro Abe, Hiroshi Shimizu
- Organizer
  The 42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089
[Presentation] Gene-edition targeting mutation site recovers null-expression of type VII collagen caused by frameshift mutation via non-homologous end joining in recessive dystrophic epidermolysis bullosa.2017
- Author(s)
  Takashima S, Shinkuma S, Fujita Y, Nomura T, Ujiie H, Abe R, Shimizu H
- Organizer
  The 73rd Annual Meeting of the Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01572
[Presentation] Long lasting epithelization after cultured epidermal autograft with revertant mosaicism in recessive dystrophic epidermolysis bullosa.2017
- Author(s)
  Matsumura W, Fujita Y, Nakamura H, Nishie W, Shinkuma S, Ujiie I, Nakayama C, Takashima S, Sawamura D, Inoie M, Shimizu H
- Organizer
  DebRA International 2017
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H01572
[Presentation] Gene-edition targeting mutation site recovers null-expression of type VII collagen caused by frameshift mutation via non-homologous end joining in Recessive Dystrophic Epidermolysis Bullosa2017
- Author(s)
  S Takashima, S Shinkuma, Y Fujita, T Nomura, H Ujiie, R Abe, H Shimizu
- Organizer
  the 76th annual meeting of society for investigative dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17H05089
[Presentation] A case of recessive dystrophic epidermolysis bullosa with a novel c.6885_6898del14 mutation.2017
- Author(s)
  Satoru Shinkuma, Tae Masunaga, Saori Miyawaki, Shota Takashima, Toshifumi Nomura, Yasuyuki Fujita, Hideki Nakamura, Hiroshi Shimizu
- Organizer
  The 76th Annual Meeting of the SOCIETY FOR INVESTIGATIVE DERMATOLOGY
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K15540
[Presentation] Long-term follow-up of cultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient2012
- Author(s)
  新熊悟
- Place of Presentation
  Raleigh Convention Center(米国)
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-23890006
[Presentation] Long-term follow-up of cultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient2012
- Author(s)
  Shinkuma S, Sawamura D, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
- Organizer
  72nd Annual Meeting of the SOCIETY FOR INVESTIGATIVE DERMATOLOGY
- Place of Presentation
  Raleigh Convention Center（米国）
- Data Source
  KAKENHI-PROJECT-24659516
[Presentation] Long-term follow-up of cultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient2012
- Author(s)
  Shinkuma S, Sawamura D, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
- Organizer
  72nd Annual Meeting of the SOCIETY FOR INVESTIGATIVE DERMATOLOGY
- Place of Presentation
  Raleigh Convention Center（米国）
- Data Source
  KAKENHI-PROJECT-23890006
[Presentation] ケラチン5のコイル1A領域N末端部にミスセンス変異を生じた単純型表皮水疱症2012
- Author(s)
  新熊悟
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-24659516
[Presentation] ケラチン5のコイル1A領域N末端部にミスセンス変異を生じた単純型表皮水疱症2012
- Author(s)
  新熊　悟、西江　渉、Jacyk WK、夏賀　健、氏家英之、中村秀樹、秋山真志、清水　宏
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  ロイトン札幌（北海道）
- Data Source
  KAKENHI-PROJECT-23890006
[Presentation] Long-term follow-up ofcultured epidermal autograft in a recessive dystrophic epidermolysis bullosa patient2012
- Author(s)
  新熊悟
- Place of Presentation
  Raleigh Convention Center(米国)
- Year and Date
  2012-05-10
- Data Source
  KAKENHI-PROJECT-24659516
[Presentation] ケラチン5のコイル1A領域N末端部にミスセンス変異を生じた単純型表皮水疱症2012
- Author(s)
  新熊悟
- Organizer
  第76回日本皮膚科学会東部支部学術大会
- Place of Presentation
  ロイトン札幌(北海道)
- Year and Date
  2012-09-30
- Data Source
  KAKENHI-PROJECT-23890006

1. Nishie Wataru (20443955)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
2. SHIMIZU Hiroshi (00146672)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
3. Hideo Asada (60252681)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
4. UJIIE HIDEYUKI (60374435)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. NATSUGA KEN (70645457)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
6. ITO Kei (20421977)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. Riichiro Abe (60344511)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 柳輝希 (50755973)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 岩田浩明 (20397334)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 乃村俊史 (50399911)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
11. 藤田靖幸 (80374437)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
12. 小澤岳昌 (40302806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 朝長毅 (80227644)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 森康子 (50343257)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
15. 西村友紀 (90812420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NAKAMURA Hideki

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
17. 宮川史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
18. 玉井克人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Shinkuma Satoru 新熊 悟

SHINKUMA Satoru 新熊 悟

Research Projects

Research Products

Co-Researchers

X染色体不活性化機構を応用したモザイクマウスを用いた細胞増殖優位性獲得機序の解明Principal Investigator

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Elucidation of the elimination mechanism of HHV-6 infected cells with a focus on NK cells in DIHS

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Elucidation of the mechanism for revertant mosaicism using model micePrincipal Investigator

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Elucidation of the pathogenic mechanism of autoimmune diseases focusing on HHV-6 persistent infection in DIHS

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Elucidation of specific cell death mechanism and biomarker search in severe drug eruption

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Establishment of epidermolysis bullosa model mouse with revertant mosaicism and its treatment

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Regenerative therapy using gene-edited iPS cells derived from an epidermolysis bullosa patientPrincipal Investigator

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Generation of model mice using CRISPR/Cas9Principal Investigator

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遺伝子編集技術を用いた表皮水疱症の多角的再生医療の開発Principal Investigator

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Production of a novel blistering disease model by regulating expression of collagen XVII

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Pathogenic roles of collagen XVII in migration of basal keratinocytes

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Generation of dominant dystrophic epidermolysis bullosa model mice using humanized COL7 mice

Principal Investigator

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New insight into genotype-phenotype correlation in recessive dystrophic epidermolysis bullosaPrincipal Investigator

Principal Investigator

Project Period (FY)

Shinkuma Satoru 新熊悟

SHINKUMA Satoru 新熊悟