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Jiang Meizi  姜 美子

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JIANG Meizi  姜 美子

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Researcher Number 00624066
Affiliation (Current) 2025: 東邦大学, 医学部, 非常勤研究生
Affiliation (based on the past Project Information) *help 2018 – 2022: 東邦大学, 医学部, 非常勤研究生
2016: 東邦大学, 医学部, 非常勤研究生
2014 – 2015: 東邦大学, 医学部, 研究員
2013: 東邦大学, 医学部, 博士研究員
2012: 千葉大学, 医学(系)研究科(研究院), 研究員
Review Section/Research Field
Principal Investigator
Metabolomics / Basic Section 52010:General internal medicine-related
Except Principal Investigator
Laboratory medicine
Keywords
Principal Investigator
糖尿病 / 可溶性LR11 / 褐色脂肪 / 肥満 / LR11 / インスリン抵抗性 / 熱代謝 / 検査学 / 検査医学 / 可溶性 … More / ブラウニング / 病的フェノタイプ変換 / ベージュ脂肪 / ディファレンシエーション / 脂肪細胞 / LDLレセプタースーパーファミリー / フェノタイプ変換 / 皮下脂肪 / ノックアウトマウス / 褐色分化 / 機能獲得 / 褐色細胞 / エネルギー消費 / 脂肪分化 / 脂質代謝異常症 / 脂質代謝異常 / メタボリックシンドローム … More
Except Principal Investigator
熱産生 / 基礎代謝 / 褐色脂肪 / 黄斑前膜 / 肺高血圧 / LR11 / アルツハイマー病 / 肺高血圧症 / リンパ腫 / 検査マーカー / 病的細胞 / LR11 / 可溶性 Less
  • Research Projects

    (4 results)
  • Research Products

    (29 results)
  • Co-Researchers

    (11 People)
  •  Establishment of examinational basis for pathological trans-differentiation of adipocytes through soluble LR11Principal Investigator

    • Principal Investigator
      Jiang Meizi
    • Project Period (FY)
      2018 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52010:General internal medicine-related
    • Research Institution
      Toho University
  •  Identification of the pathologically-transited immature cells diagnosed by soluble LR11

    • Principal Investigator
      BUJO Hideaki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Toho University
  •  Molecular basis of the severe ectopic browning transition of adipocytes in novel mice with resistance against obesity and diabetesPrincipal Investigator

    • Principal Investigator
      JIANG Meizi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Metabolomics
    • Research Institution
      Toho University
  •  Clarification of mechanism underlying adipocyte differentiation using a novel model for ectopic accumulation of brown fat tissuesPrincipal Investigator

    • Principal Investigator
      JIANG Meizi
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Metabolomics
    • Research Institution
      Toho University
      Chiba University

All 2022 2021 2020 2019 2018 2017 2016 2015 2014 2013 2012

All Journal Article Presentation

  • [Journal Article] Soluble LR11 as a Novel Biomarker in Acute Kawasaki Disease2022

    • Author(s)
      Watanabe Kenichi、Suzuki Hiroshi、Jiang Meizi、Tsukano Shinya、Kataoka Satoshi、Ito Sueshi、Sakai Takatsugu、Hirokawa Toru、Saitoh Akihiko、Bujo Hideaki
    • Journal Title

      Circ J

      Volume: 86 Issue: 6 Pages: 977-983

    • DOI

      10.1253/circj.CJ-20-1271

    • NAID

      130008088823

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2022-05-25
    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07840, KAKENHI-PROJECT-18K19526, KAKENHI-PROJECT-18K07428
  • [Journal Article] LR11, an LDL Receptor Gene Superfamily Member, Represses the Norepinephrine-Induced Expression of Uncoupling Protein 1 in Primary Cultured Beige Adipocytes2021

    • Author(s)
      Shoko Nakamura, Meizi Jiang, Rena Oka, Takashi Yamaguchi, Nobuyuki Hiruta, Hiroyuki Ebinuma, Wolfgang J Schneider, Ichiro Tatsuno and Hideaki Bujo
    • Journal Title

      Toho Journal of Medicine

      Volume: 7 Issue: 1 Pages: 48-56

    • DOI

      10.14994/tohojmed.2020-019

    • NAID

      120006976149

    • ISSN
      21891990
    • URL

      https://toho.repo.nii.ac.jp/records/2002962

    • Year and Date
      2021-03-01
    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07428, KAKENHI-PROJECT-18K19526
  • [Journal Article] Levels of circulating soluble LR11, a regulator of smooth muscle cell migration, are highly associated with atherosclerotic plaques in patients with carotid artery stenosis2019

    • Author(s)
      Harada M, Jiang M, Terai K, Ebinuma H, Hiruta N, Schneider WJ, Sugo N, Nagao T, Bujo H
    • Journal Title

      Clin Chim Acta

      Volume: 490 Pages: 69-76

    • DOI

      10.1016/j.cca.2018.12.005

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07428, KAKENHI-PROJECT-16H05231
  • [Journal Article] Susceptibilities of epicardial and subcutaneous fat tissue for browning-gene expression and diet-induced volume reduction are different2018

    • Author(s)
      Mikamo H, Jiang M, Noro M, Suzuki Y, Hiruta N, Unoki-Kubota H, Schneider WJ, Bujo H.
    • Journal Title

      Mol Med Rep

      Volume: 17 Pages: 6542-6550

    • DOI

      10.3892/mmr.2018.8690

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16H05231, KAKENHI-PROJECT-18K07428
  • [Journal Article] Soluble form of LR11 is highly increased in the vitreous fluids of patients with idiopathic epiretinal membrane.2017

    • Author(s)
      Hashimoto R, Jiang M, Shiba T, Hiruta N, Takahashi M, Higashi M, Hori Y, Bujo H, Maeno T.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol.

      Volume: 255 Issue: 5 Pages: 885-891

    • DOI

      10.1007/s00417-017-3585-1

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K10882
  • [Journal Article] Deletion of LR11 attenuates hypoxia-induced pulmonary arterial smooth muscle cell proliferation with medial thickening in mice.2016

    • Author(s)
      Jiang L, Konishi H, Nurwidya F, Satoh K, Takahashi F, Ebinuma H, Fujimura K, Takasu K, Jiang M, Shimokawa H, Bujo H, Daida H.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 36 Issue: 9 Pages: 1972-1979

    • DOI

      10.1161/atvbaha.116.307900

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04816, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K09127
  • [Journal Article] Prognostic impact of circulating soluble LR11 on long-term clinical outcomes in patients with coronary artery disease2016

    • Author(s)
      Ogita M, Miyauchi K, Kasai T, Tsuboi S, Wada H, Naito R, Konishi H, Dohi T, Tamura H, Okazaki S, Yanagisawa N, Shimada K, Suwa S, Jiang M, Bujo H, Daida H
    • Journal Title

      Atherosclerosis

      Volume: 244 Pages: 216-221

    • DOI

      10.1016/j.atherosclerosis.2015.11.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-16K19431
  • [Journal Article] Serum soluble LR11, a novel tumor derived biomarker associated with the outcome of patients with diffuse large B-cell lymphoma.2015

    • Author(s)
      Ohwada C, Yamazaki A, Kawaguchi T, Sugita Y, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Tsukamoto S, Muto T, Jiang M, Higashi M, Yokote K, Tamaru JI, Bujo H, Nakaseko C.
    • Journal Title

      Leuk Lymphoma.

      Volume: 印刷中 Issue: 10 Pages: 1-4

    • DOI

      10.3109/10428194.2015.1016930

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-25461409, KAKENHI-PROJECT-15K15198, KAKENHI-PROJECT-15K08366, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-26293165
  • [Journal Article] Soluble LR11/SorLA represses thermogenesis in adipose tissue and correlates with BMI in humans.2015

    • Author(s)
      Whittle AJ, Jiang M, Peirce V, Relat J, Virtue S, Ebinuma H, Fukamachi I, Yamaguchi T, Takahashi M, Murano T, Tatsuno I, Takeuchi M, Nakaseko C, Jin W, Jin Z, Campbell M, Schneider WJ, Vidal-Puig A, Bujo H.
    • Journal Title

      Nat Commun

      Volume: 6 Issue: 1 Pages: 8951-8951

    • DOI

      10.1038/ncomms9951

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461369
  • [Journal Article] Unsuppressed lipolysis in adipocytes is linked with enhanced gluconeogenesis and altered bile acid physiology in Insr(P1195L/+) mice fed high-fat-diet.2015

    • Author(s)
      Lee EY, Sakurai K, Zhang X, Toda C, Tanaka T, Jiang M, Shirasawa T, Tachibana K, Yokote K, Vidal-Puig A, Minokoshi Y, Miki T.
    • Journal Title

      Sci Rep

      Volume: 30 Issue: 1 Pages: 17565-17565

    • DOI

      10.1038/srep17565

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461369, KAKENHI-PROJECT-15K14375, KAKENHI-PROJECT-26670362, KAKENHI-PROJECT-25293051, KAKENHI-PROJECT-26293165
  • [Journal Article] Soluble LR11 is a novel biomarker for vascular lesions late after Kawasaki disease.2015

    • Author(s)
      Watanabe K, Suzuki H, Jiang M, Haniu H, Numano F, Hoshina S, Saitoh A, Uchiyama M, Bujo H.
    • Journal Title

      Atherosclerosis

      Volume: 246 Pages: 94-97

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461369
  • [Journal Article] Prognostic impact of circulating soluble LR11 on long-term clinical outcomes in patients with coronary artery disease.2015

    • Author(s)
      Ogita M, Miyauchi K, Kasai T, Tsuboi S, Wada H, Naito R, Konishi H2, Dohi T2, Tamura H2, Okazaki S2, Yanagisawa N, Shimada K, Suwa S, Jiang M, Bujo H, Daida H
    • Journal Title

      Atherosclerosis

      Volume: 244 Pages: 216-221

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461369
  • [Journal Article] Tetraspanin CD9 modulates ADAM17-mediated shedding of LR11 in leukocytes.2014

    • Author(s)
      Tsukamoto S, Takeuchi M, Kawaguchi T, Togasaki E, Yamazaki A, Sugita Y, Muto T, Sakai S, Takeda Y, Ohwada C, Sakaida E, Shimizu N, Nishii K, Jiang M, Yokote K, Bujo H, Nakaseko C.
    • Journal Title

      Exp Mol Med.

      Volume: - Issue: 4 Pages: 46-89

    • DOI

      10.1038/emm.2013.161

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-26461369
  • [Journal Article] Circulating soluble LR11, a novel marker of smooth muscle cell proliferation, is enhanced after coronary stenting in response to vascular injury.2014

    • Author(s)
      Ogita M, Miyauchi K, Jiang M, Kasai T, Tsuboi S, Naito R, Konishi H1, Dohi T1, Yokoyama T, Okazaki S, Shimada K, Bujo H, Daida H
    • Journal Title

      Atherosclerosis.

      Volume: 237 Pages: 374-378

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26461369
  • [Journal Article] Vitreous fluid and circulating levels of soluble lr11, a novel marker for progression of diabetic retinopathy2013

    • Author(s)
      Shiba T, Bujo H, Takahashi M, Sato Y, Jiang M, Hori Y, Maeno T, Shirai K
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 251(12) Issue: 12 Pages: 2689-95

    • DOI

      10.1007/s00417-013-2373-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] Amyloid cascade and tau pathology cerebrospinal fluid markers in mild cognitive impairment with regards to Alzheimer's disease cerebral metabolic signature2013

    • Author(s)
      Alexopoulos P, Guo LH, Jiang M, Bujo H, Grimmer T, Förster S, Drzezga A, Kurz A, Perneczky R
    • Journal Title

      J Alzheimers Dis

      Volume: 36(2) Issue: 2 Pages: 401-8

    • DOI

      10.3233/jad-122329

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] Increased circulating soluble LR11 in patients with acute coronary syndrome2013

    • Author(s)
      Ogita M, Miyauchi K, Dohi T, Tsuboi S, Miyazaki T, Yokoyama T, Yokoyama K, Shimada K, Kurata T, Jiang M, Bujo H, Daida H
    • Journal Title

      Clin Chim Acta

      Volume: 16(415) Pages: 191-4

    • DOI

      10.1016/j.cca.2012.10.047

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] The soluble form of LR11 is a regulator of hypoxia-induced, uPAR-mediated adhesion of immature hematological cells2013

    • Author(s)
      Keigo Nishii, Chiaki Nakaseko, Meizi Jiang, Naomi Shimizu, Masahiro Takeuchi, Wolfgang Johann Schneider, and Hideaki Bujo
    • Journal Title

      The Journal of Biological Chemistry

      Volume: 288(17) Issue: 17 Pages: 11877-11886

    • DOI

      10.1074/jbc.m112.442491

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591368, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
  • [Journal Article] β-Site amyloid precursor protein-cleaving enzyme 1 activity is related to cerebrospinal fluid concentrations of sortilin-related receptor with A-type repeats, soluble amyloid precursor protein, and tau2013

    • Author(s)
      Tsolakidou A, Alexopoulos P, Guo LH, Grimmer T, Westerteicher C, Kratzer M, Jiang M, Bujo H, Roselli F, Leante MR, Livrea P, Kurz A, Perneczky R
    • Journal Title

      Alzheimers Dement

      Volume: 9(4) Issue: 4 Pages: 386-91

    • DOI

      10.1016/j.jalz.2012.01.015

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] LR11 : a novel biomarker identified in follicular lymphoma2013

    • Author(s)
      Kawaguchi T, Ohwada C, Takeuchi M, Shimizu N, Sakaida E, Takeda Y, Sakai S, Tsukamoto S, Yamazaki A, Sugita Y, Jiang M, Higashi M, Yokote K, Tamura J, Bujo H, Nakaseko C
    • Journal Title

      Br J Haematol

      Volume: 163(2) Issue: 2 Pages: 277-280

    • DOI

      10.1111/bjh.12467

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23390185, KAKENHI-PROJECT-23590413, KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24659346, KAKENHI-PROJECT-24790907, KAKENHI-PROJECT-25461409
  • [Journal Article] Interrelations between CSF soluble AβPPβ, amyloid-β 1-42, SORL1, and tau levels in Alzheimer's disease2012

    • Author(s)
      Alexopoulos P, Guo LH, Tsolakidou A, Kratzer M, Grimmer T, Westerteicher C, Jiang M, Bujo H, Diehl-Schmid J, Kurz A, Perneczky R
    • Journal Title

      J Alzheimers Dis

      Volume: 28(3) Issue: 3 Pages: 543-52

    • DOI

      10.3233/jad-2011-110983

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] Circulating Soluble LRU in Patients with Diabetic Retinopathy.2012

    • Author(s)
      Takahashi M, Bujo H, Shiba T, Jiang M, Maeno T, Shirai K
    • Journal Title

      Am J Ophthalmol

      Volume: 154 Issue: 1 Pages: 187-192

    • DOI

      10.1016/j.ajo.2012.01.035

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24390231, KAKENHI-PROJECT-24790907
  • [Journal Article] SORL1 genetic variants and cerebrospinal fluid biomarkers of Alzheimer's disease2012

    • Author(s)
      Guo LH, Westerteicher C, Wang XH, Kratzer M, Tsolakidou A, Jiang M, Grimmer T, Laws SM, Alexopoulos P, Bujo H, Kurz A, Perneczky R
    • Journal Title

      Eur Arch Psychiatry Clin Neurosci

      Volume: 262(6) Pages: 529-34

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/22286501

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24790907
  • [Journal Article] Circulating soluble LR11/SorLA levels are highly increased and ameliorated by chemotherapy in acute leukemias2012

    • Author(s)
      Sakai S, Nakaseko C, Takeuchi M, Ohwada C, Shimizu N, Tsukamoto S, Kawaguchi T, Jiang M, Sato Y, Ebinuma H, Yokote K, Iwama A, Fukamachi I, Schneider WJ, Saito Y, Bujo H.
    • Journal Title

      Clin Chim Acta

      Volume: 96 Issue: 19-20 Pages: 542-1548

    • DOI

      10.1016/j.cca.2012.06.025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24591380, KAKENHI-PROJECT-24790907
  • [Presentation] 疾患マーカーとしての可溶性リポ蛋白受容体-脂肪細胞バイオマーカ ーの可能性-2020

    • Author(s)
      姜 美子, 武城英明
    • Organizer
      第52回日本動脈硬化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K07428
  • [Presentation] The LDL-receptor relative LR11 is an autonomous regulator of white-to-beige trans-differentiation in polymer-scaffold 3D-cultured adipocytes.2019

    • Author(s)
      Meizi Jiang, Tatsuro Kanaki, Akiteru Hayashi, Hiroyuki Ebinuma, Wolfgang J. Schneider, Hideaki Bujo
    • Organizer
      American Heart Association(AHA)Scientific Sessions 2019
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07428
  • [Presentation] ベージュ脂肪は高脂肪摂取マウスの脂質異常を抑制する―脂肪の質を変える食事生活指導の可能性―2018

    • Author(s)
      姜 美子, Antonio Vidal-Puig, Monique T. Mulder, Wolfgang J.Schneider, 武城英明
    • Organizer
      第50回日本動脈硬化学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-18K07428
  • [Presentation] Expression of LR11/SorLA, a thermogenesis suppressor, is regulated in adipogenesis of cultured adipocytes2018

    • Author(s)
      Jiang M, Ebinuma H, Murano T, Bujo H
    • Organizer
      25th European Congress on Obesity
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K07428
  • [Presentation] Identification of a regulator for energy expenditure in adipose tissues2016

    • Author(s)
      姜 美子、武城 英明
    • Organizer
      18th International Conference on Emerging Infectious Diseases (EID)
    • Place of Presentation
      ワシントンD.C.(アメリカ)
    • Year and Date
      2016-01-13
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461369
  • 1.  BUJO Hideaki (80291300)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 10 results
  • 2.  SHIMIZU Naomi (30375802)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 3 results
  • 3.  HIGASHI Morihiko (00323395)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 4.  HIRUTA Nobuyuki (50201736)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 5.  NAGAO Tateki (20167555)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  NAKASEKO Chiaki (30323398)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  IKEUCHI Takeshi (20372469)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  Antonio Vidal-Puig
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  SATOH Kimio
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 10.  武内 正博
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 11.  横手 幸太郎
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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