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Ikeuchi Takeshi  池内 健

… Alternative Names

池内 健  イケウチ タケシ

IKEUCHI Takeshi  池内 健

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Researcher Number 20372469
Other IDs
  • ORCIDhttps://orcid.org/0000-0001-8828-8085
External Links
Affiliation (Current) 2022: 新潟大学, 脳研究所, 教授
Affiliation (based on the past Project Information) *help 2019 – 2022: 新潟大学, 脳研究所, 教授
2013 – 2017: 新潟大学, 脳研究所, 教授
2016: 新潟大学, 医学部, 教授
2011 – 2012: 新潟大学, 研究推進機構, 准教授
2010 – 2011: 新潟大学, 研究推進機構超域学術院, 准教授
2007 – 2010: Niigata University, Brain Research Institute, 助教
2004 – 2006: 新潟大学, 脳研究所, 助手
Review Section/Research Field
Principal Investigator
Neurology / Biological Sciences / Basic Section 52020:Neurology-related / 基礎ゲノム科学
Except Principal Investigator
Basic Section 52020:Neurology-related / Medical genome science / Nerve anatomy/Neuropathology / Basic Section 48040:Medical biochemistry-related / Human pathology / Laboratory medicine / General internal medicine(including psychosomatic medicine) / Basic Section 52030:Psychiatry-related
Keywords
Principal Investigator
認知症 / アルツハイマー病 / シグナル伝達 / ミクログリア / 大脳白質 / 脳神経疾患 / プレセニリン / 神経科学 / 脂質 / 薬理学 … More / 遺伝子発現 / タウ / 神経変性 / アミロイド前駆体タンパク / Alzheimer disease / 遺伝子変異 / セクレターゼ / プロテアーゼ / 阻害剤 / 遷移状態アナログ / 糖尿病 / インスリンシグナル伝達 / 神経疾患 / 遺伝子コピー数 / 遺伝性神経疾患 / 遺伝子同定 / ゲノムワイド解析 / 候補遺伝子アプローチ / 遺伝性精神疾患 / アミロイド / リン酸化 / 転写障害 / 神経細胞死 / Transcription / Amyloid precursor protein / Neuronal cell death / Presenilin / アルツハイマー型認知症 / コレステロール / スタチン / cholesterol / statin / amyloid precursor protein / tau / アミノ酸 / ネットワーク / 神経病理学 / 細胞移植 … More
Except Principal Investigator
アルツハイマー病 / バイオマーカー / タウオパチー / アストロサイト / 神経変性疾患 / 認知症 / 遺伝子発現 / リスク遺伝子 / タウ / 神経変性 / CSF1R / ミクログリア / ALSP / 多系統萎縮症 / 臨床医学研究 / 基礎医学研究 / トランスレーションリサーチ / 科学研究費 / トランスレーショナルリサーチ / 前頭側頭葉型認知症 / CHMP2B / オートファジー / ユビキチン陽性封入体 / ALS / エンドソーム / 前頭側頭型認知症 / ゲノム / 脳組織 / ターゲット分子 / 染色体 / 培養細胞 / 老人斑 / 神経原繊維変化 / 次世代シークエンサー / RNA / 死後脳 / トランスクリプトーム / globular glial tauopathy / オリゴマー / ピック病 / タウオリゴマー / 進行性核上性麻痺 / 筋萎縮性側索硬化症 / 神経病理学 / 脳神経疾患 / TDP-43 / 可溶性 / LR11 / 病的細胞 / 検査マーカー / リンパ腫 / 肺高血圧症 / LR11 / 肺高血圧 / 黄斑前膜 / 褐色脂肪 / 基礎代謝 / 熱産生 / 糖尿病 / 遺伝子 / 痴呆 / βアミロイド / microglia / macrophage / astrocyte / leukoencephalopathy / CSF1R / 白質脳症 / rare variants / association study / 低頻度バリアント / rare variant / 関連解析 / exome解析 / 多発性硬化症 / Bassoon / パーキンソニズム / モデル動物 / ショウジョウバエ / 遺伝子変異 / スクリーニング / 脳脊髄液 / 血液 / 伸長リピート配列 / ロングリードシーケンス Less
  • Research Projects

    (27 results)
  • Research Products

    (191 results)
  • Co-Researchers

    (72 People)
  •  comprehensive search for expanded repeats in neurodegenerative diseaess

    • Principal Investigator
      辻 省次
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      International University of Health and Welfare
  •  Loss of homeostatic microglia and cell replacement therapy in primary microgliopathyPrincipal Investigator

    • Principal Investigator
      池内 健
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  認知症治療標的としてのミクログリアによるアストロサイト制御機構に剖検脳から迫る

    • Principal Investigator
      他田 真理
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52030:Psychiatry-related
    • Research Institution
      Niigata University
  •  タウオパチー病態機序解明を目指すゲノムリソースの網羅的機能解析

    • Principal Investigator
      杉江 淳
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  多系統萎縮症の3つの病態を反映し,早期診断を可能とするバイオマーカーの検討と確立

    • Principal Investigator
      徳武 孝允
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  Bassoon proteinopathyの病態解析研究

    • Principal Investigator
      矢部 一郎
    • Project Period (FY)
      2020 – 2022
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Hokkaido University
  •  白質脳症におけるミクログリアによるアストロサイトの制御機構

    • Principal Investigator
      他田 真理
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  低頻度バリアントに重点をおくアルツハイマー病の発症に関与する遺伝子の探索法開発

    • Principal Investigator
      辻 省次
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 48040:Medical biochemistry-related
    • Research Institution
      International University of Health and Welfare
  •  Impaired essential function of microglia in the pathogenesis of HDLS/ALSPPrincipal Investigator

    • Principal Investigator
      池内 健
    • Project Period (FY)
      2019 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 52020:Neurology-related
    • Research Institution
      Niigata University
  •  CSF-1受容体異常によるミクログリア機能破綻と一次性ミクログリア病の病態Principal Investigator

    • Principal Investigator
      池内 健
    • Project Period (FY)
      2016 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Niigata University
  •  Amino acid profile in plasma of Alzheimer's diseasePrincipal Investigator

    • Principal Investigator
      Ikeuchi Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Validation study on insulin resistance occuring in brain of Alzheimer diseasePrincipal Investigator

    • Principal Investigator
      Ikeuchi Takeshi
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Identification of the pathologically-transited immature cells diagnosed by soluble LR11

    • Principal Investigator
      BUJO Hideaki
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Challenging Exploratory Research
    • Research Field
      Laboratory medicine
    • Research Institution
      Toho University
  •  一次性ミクログリア病:CSF-1R変異関連HDLSにおけるミクログリアの機能異常Principal Investigator

    • Principal Investigator
      池内 健
    • Project Period (FY)
      2014 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • Review Section
      Biological Sciences
    • Research Institution
      Niigata University
  •  Globular glial tauopathy: investigation of the pathological features

    • Principal Investigator
      TOYOSHIMA Yasuko
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Niigata University
  •  Amyotrophic Lateral Sclerosis and TDP-43: Elucidation of molecular neuropathology in terms of spread from its beginning

    • Principal Investigator
      Takahashi Hitoshi
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Nerve anatomy/Neuropathology
    • Research Institution
      Niigata University
  •  Analysis of the mechanism of homeostatic maintenance against Alzheimer's disease and its failure due to diabetes

    • Principal Investigator
      SATO Naoyuki
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General internal medicine(including psychosomatic medicine)
    • Research Institution
      National Center for Geriatrics and Gerontology
      Osaka University
  •  Identification of target molecules related the progression of Alzheimer's disease

    • Principal Investigator
      KUWANO Ryozo
    • Project Period (FY)
      2012 – 2014
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Medical genome science
    • Research Institution
      Niigata University
  •  末梢血におけるアルツハイマー病脳関連遺伝子のエピジェネティック・遺伝子発現解析

    • Principal Investigator
      宮下 哲典
    • Project Period (FY)
      2012 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Medical genome science
    • Research Institution
      Niigata University
  •  Genetical, morphological, and functional analysis of CHMP2B in a patient of familial FTD

    • Principal Investigator
      TOYOSHIMA Yasuko
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Human pathology
    • Research Institution
      Niigata University
  •  Non-biased expression analysis to search for molecules associated with amyloid-beta induced hyperphosphorylation of tauPrincipal Investigator

    • Principal Investigator
      IKEUCHI Takeshi
    • Project Period (FY)
      2011 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Mutations associated with copy number variation in neurological disordersPrincipal Investigator

    • Principal Investigator
      IKEUCHI Takeshi
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
    • Research Field
      Neurology
      基礎ゲノム科学
    • Research Institution
      Niigata University
  •  A role of insulin signal impairment in the pathogenesis of Alzheimer diseasePrincipal Investigator

    • Principal Investigator
      IKEUCHI Takeshi
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  Global survey on clinical research supporting and promoting system, aiming Japanese clinical research improvement.

    • Principal Investigator
      YAMADA Nobuhiro
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Special Purposes
    • Research Institution
      University of Tsukuba
  •  Modulation of β-amyloid and phosphorylated tau production by statinPrincipal Investigator

    • Principal Investigator
      IKEUCHI Takeshi
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University
  •  特異的γセクレターゼ阻害剤を用いた活性型プレセニリン複合体の調節機構の解析Principal Investigator

    • Principal Investigator
      池内 健
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Niigata University
  •  A role of transcriptional impairment in pathogenesis for Alzheimer diseasePrincipal Investigator

    • Principal Investigator
      IKEUCHI Takeshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Neurology
    • Research Institution
      Niigata University

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 Other

All Journal Article Presentation Book

  • [Book] Annual Review神経20192019

    • Author(s)
      今野卓哉,野崎洋明,池内 健,小野寺理
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Book] 認知症診療Q&A2012

    • Author(s)
      池内 健,他
    • Publisher
      中外医学社
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Book] 最新医学生化学マーカー,遺伝子2011

    • Author(s)
      池内 健,他
    • Total Pages
      2122
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Book] 日本臨床,認知症学 (上)2011

    • Author(s)
      池内 健,他
    • Total Pages
      103
    • Publisher
      Progranulin
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Book] 綜合臨牀認知症の疫学・遺伝学2011

    • Author(s)
      池内 健
    • Total Pages
      1809
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Book] Dentatorubral-pallidoluysian atrophy (DRPLA) : clinical and genetic features, and neuroimaging2008

    • Author(s)
      Ikeuchi, et al.
    • Total Pages
      172
    • Publisher
      Research Singpost
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Book] Dentatorubral-pallidoluysian atrophy(DRPLA): clinical and genetic features, and neuroimaging.2008

    • Author(s)
      Ikeuchi, et. al.
    • Publisher
      Research Signpost(印刷中)
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Book] Dentatorubral-pallidoluysian atrophy (DRPい): clinical and genetic features, and neuroimaging.

    • Author(s)
      Ikeuchi, et. al.
    • Publisher
      Research Signpost (In press)
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] Sporadic Japanese case of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia caused by a de novo p.Phe849del mutation in CSF1R.2020

    • Author(s)
      Senzaki S, Miura S, Ochi M, Kato T, Okada T, Matsumoto S, Shiraoka A, Ochi H, Igase M, Kitazawa R, Zhu B, Ikeuchi T, Ohyagi Y
    • Journal Title

      Neurology Clinical Neuroscience

      Volume: 8 Pages: 96-98

    • DOI

      10.1111/ncn3.12367

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Journal Article] Biallelic hypomorphic mutations in CSF1R associated with fatal childhood neurodegeneration.2020

    • Author(s)
      Tamhankar PM, Zhu B, Tamhankar VP, Withbawkar SM, Seabra L, Livingston J, Ikeuchi T, Crow YJ.
    • Journal Title

      Neuropediatrics

      Volume: 51 Pages: 302-306

    • DOI

      10.1055/s-0040-1702161

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Journal Article] Novel CHP1 mutation in autosomal-recessive cerebellar ataxia: autopsy features of two siblings.2020

    • Author(s)
      Saito Rie、Hara Norikazu、Tada Mari、Honma Yoshiaki、Miyashita Akinori、Onodera Osamu、Ikeuchi Takeshi、Kakita Akiyoshi
    • Journal Title

      Acta Neuropathol Commun

      Volume: 8 Pages: 134-134

    • DOI

      10.1186/s40478-020-01008-2

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K07972, KAKENHI-PROJECT-20K20468
  • [Journal Article] ミクログリアの機能破綻を原因とする一次性ミクログリオパチー2019

    • Author(s)
      池内 健,朱 斌
    • Journal Title

      実験医学

      Volume: 37 Pages: 2926-2930

    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Journal Article] Remarkable behavioral signs and progressive non-fluent aphasia in a patient with adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)2019

    • Author(s)
      Funayama M, Sugihara M, Takata T, Mimura M, Ikeuchi T.
    • Journal Title

      Psychogeriatrics

      Volume: 2019 Pages: 282-285

    • DOI

      10.1111/psyg.12387

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Journal Article] A sporadic case of young-onset rapidly progressive dementia with a novel frameshift mutation in exon 3 of the CSF1R gene.2019

    • Author(s)
      Kawazoe T, Abe K, Ikeuchi T, Miura T, Mezaki N, Tsukamoto T, Takahashi Y
    • Journal Title

      Neurology Clinical Neuroscience

      Volume: 7 Pages: 103-104

    • DOI

      10.1111/ncn3.12259

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Journal Article] Diagnostic criteria for adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)2018

    • Author(s)
      Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
    • Journal Title

      European Journal of Neurology

      Volume: 25 Pages: 142-147

    • DOI

      10.1111/ene.13464

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Journal Article] Cognitive dysfunction and symptoms of movement disorders in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia2018

    • Author(s)
      Ikeuchi T, Mezaki N, Miura T
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 46 Pages: 39-46

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Journal Article] Partial loss of function of colony-stimulating factor 1 receptor in a patient with white matter abnormalities2018

    • Author(s)
      Konno T, Miura T, Harriott A, Mezaki N, Edwards ES, Ross OA, Meschia JF, Ikeuchi T, Wszolek ZK
    • Journal Title

      European Journal of Neurology

      Volume: 印刷中 Pages: 875-881

    • DOI

      10.1111/ene.13611

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331, KAKENHI-WRAPUP-18H05199
  • [Journal Article] Effects of super hard rice bread blended with black rice bran on amyloid  peptide production and abrupt increase in postprandial blood glucose levels in mice2017

    • Author(s)
      S.Nakamura, T.Hara, T.Joh, A.Kobayashi, A.Yamazaki, K.Kasuga, T.Ikeuchi, K.Ohtsubo
    • Journal Title

      Bioscience, Biotechnology, Biochemistry

      Volume: 81 Pages: 323-334

    • DOI

      10.1080/09168451.2016.1240605

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-15H02891, KAKENHI-PROJECT-15K15335
  • [Journal Article] Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia associated with CSF1R mutation2017

    • Author(s)
      Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
    • Journal Title

      European Journal of Neurology

      Volume: 24 Pages: 37-45

    • DOI

      10.1111/ene.13125

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331, KAKENHI-PROJECT-15K15335
  • [Journal Article] Diagnostic value of brain calcifications in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia2017

    • Author(s)
      Konno T, Broderick DF, Mezaki N, Isami A, Kaneda D, Tashiro Y, Tokutake T, Keegan M, Woodruff BK, Miura T, Nozaki H, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
    • Journal Title

      American Journal of Neuroradiology

      Volume: 38 Pages: 77-83

    • DOI

      10.3174/ajnr.a4938

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Journal Article] Modifiable factors associated with cognitive impairment in 1143 Japanese outpatients: The Project in Sado for Total Health (PROST).2016

    • Author(s)
      Kitamura K, Watanabe Y, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Ruwano R, Momotsu T, Narita I, Endo N.
    • Journal Title

      Dementia Geriatric Cognitive Disorder EXTRA

      Volume: 6 Pages: 341-349

    • DOI

      10.1159/000447963

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Journal Article] Pathological and clinical spectrum of progressive surpranuclear palsy: with special reference to astrocytic tau pathology.2016

    • Author(s)
      Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H.
    • Journal Title

      Brain Pathol

      Volume: 26 Pages: 155-166

    • DOI

      10.1111/bpa.12265

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PLANNED-26117006, KAKENHI-PROJECT-26250017, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26640029, KAKENHI-PROJECT-15K09860
  • [Journal Article] Characteristic microglial features in patients with hereditary diffuse leukoencephalopathy with spheroids.2016

    • Author(s)
      Tada M,Konno T,Tada M, Tezuka T, Okazaki K, Arakawa M,Itoh K,Yamamoto T, Yokoo H, Yoshikura N,Ishihara K, Horie M, Takebayashi H, Toyoshima Y, Naito M, Onodera O, Nishizawa M, Takahashi H, Ikeuchi T,Kakita A
    • Journal Title

      Ann Neurol.

      Volume: 80 Pages: 554-565

    • DOI

      10.1002/ana.24754

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PUBLICLY-16H01331, KAKENHI-ORGANIZER-25117001, KAKENHI-PROJECT-16K07041
  • [Journal Article] Elevated C-reactive protein is associated with cognitive decline in outpatients of a general hospital: The Project in Sato for Total Health (PROST).2016

    • Author(s)
      Watanabe Y, Kitamura K, Nakamura K, Sanpei K, Wakasugi M, Yokoseki A, Onodera O, Ikeuchi T, Kuwano R, Momotsu T, Narita I, Endo N
    • Journal Title

      Dementia Geriatric Cognitive Disorder EXTRA

      Volume: 6 Pages: 10-16

    • DOI

      10.1159/000442585

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Journal Article] Familial idiopathic basal ganglia calcification: histopathologic features of an autopsied patient with an SLC20A2 mutation2016

    • Author(s)
      Kimura T, Miura T, Aoki K, Saito S, Hondo H, Konno T, Uchiyama A, Ikeuchi T, Takahashi H, Kakita A
    • Journal Title

      Neuropathology

      Volume: 36 Pages: 365-371

    • DOI

      10.1111/neup.12280

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Journal Article] Globular glial mixed four repeat tau and TDP-43 proteinopathy with motor neuron disease and frontotemporal dementia2016

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H.
    • Journal Title

      Brain Pathol.

      Volume: in press Pages: 82-92

    • DOI

      10.1111/bpa.12262

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25830038, KAKENHI-PROJECT-26250017, KAKENHI-PUBLICLY-26117506, KAKENHI-PROJECT-25253065, KAKENHI-PROJECT-25430048, KAKENHI-PROJECT-26640029, KAKENHI-PROJECT-15H04839
  • [Journal Article] Reduced CSF Water Influx in Alzheimer's Disease Supporting the β-Amyloid Clearance Hypothesis2015

    • Author(s)
      Suzuki Y, Nakamura Y, Yamada K, Igarashi H, Kasuga K, Yokoyama Y, Ikeuchi T, Nishizawa M, Kwee IL, Nakada T
    • Journal Title

      PLoS One

      Volume: 10

    • DOI

      10.1371/journal.pone.0123708

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335, KAKENHI-PROJECT-25461310
  • [Journal Article] ApoE-isoform-dependent cellular uptake of amyloid-b is mediated by lipoprotein receptor LR11/SorLA2015

    • Author(s)
      Yajima,et al
    • Journal Title

      Biochemical Biophysical Research Communications

      Volume: 456 Pages: 482-488

    • DOI

      10.1016/j.bbrc.2014.11.111

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25893077, KAKENHI-PROJECT-15H04839
  • [Journal Article] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Tanaka H, Shimizu H, Shiga A, Miura T, Aoki K, Aikawa A, Ishizawa S, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
    • Journal Title

      Brain Pathology

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Journal Article] Pathological and Clinical Spectrum of Progressive Supranuclear Palsy: with Special Reference to Astrocytic Tau Pathology2015

    • Author(s)
      Yokoyama Y, Toyoshima Y, Shiga A, Tada M, Kitamura H, Hasegawa K, Onodera O, Ikeuchi T, Someya T, Nishizawa M, Kakita A, Takahashi H
    • Journal Title

      Brain Pathology

      Volume: 印刷中

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Journal Article] Systematic review and meta-analysis of Japanese familial Alzheimer's disease and FTDP-172015

    • Author(s)
      Kasuga,et al
    • Journal Title

      Journal of Human Genetics

      Volume: in press Pages: 281-283

    • DOI

      10.1038/jhg.2015.15

    • NAID

      40020462601

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25893077, KAKENHI-PROJECT-26870209, KAKENHI-PROJECT-15H04839
  • [Journal Article] Variable expression of microglial DAP12 and TREM2 genes in Nasu-Hakola disease2015

    • Author(s)
      Sasaki A, Kakita A, Yoshida K, Konno T, Ikeuchi T, Hayashi S, Matsuo H, Shioda K
    • Journal Title

      Neurogenetics

      Volume: 16 Pages: 265-276

    • DOI

      10.1007/s10048-015-0451-3

    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26117506, KAKENHI-PROJECT-25430051
  • [Journal Article] Plasma desmosterol is associated with longitudinal cognitive decline in Alzheimer’s disease.2015

    • Author(s)
      Sato Y, Bernier F, Yamanaka Y, Aoshima K, Oda Y, Ingelsson M, Lannfelt L, Miyashita A, Kuwano R, Ikeuchi T
    • Journal Title

      Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring

      Volume: 1 Pages: 67-74

    • DOI

      10.1016/j.dadm.2014.11.009

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Journal Article] 神経軸索スフェロイド形成を伴う遺伝性びまん性白質脳症(HDLS)の臨床像と画像所見2014

    • Author(s)
      池内健
    • Journal Title

      臨床神経学

      Volume: 54 Pages: 1158-1161

    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Journal Article] HDLS2014

    • Author(s)
      他田正義,池内 健
    • Journal Title

      医学のあゆみ

      Volume: 249 Pages: 435-435

    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Journal Article] Clinical and neuroimaging features of patient with early-onset Parkinson's disease with dementia carrying SNCA p.G51D mutation.2014

    • Author(s)
      Tokutake T, Ishikawa A, Yoshimura N, Miyashita A, Kuwano R, Nishizawa M, Ikeuchi T
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 20 Pages: 262-264

    • DOI

      10.1016/j.parkreldis.2013.11.008

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-22129004, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25893077
  • [Journal Article] スフェロイドを伴う遺伝性びまん性白質脳症(HDLS)とCSF-1R遺伝子変異2014

    • Author(s)
      今野卓哉,他田正義,他田真理,池内 健
    • Journal Title

      Brain & Nerve

      Volume: 66 Pages: 581-590

    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Journal Article] Ratio and lebel of Aß surrogate in cerebrospinal fluid of familal Alzheimer's disease patients with presenilin 1 mutations2014

    • Author(s)
      Tagami et al.
    • Journal Title

      Neurodegener Dis. .

      Volume: 13 Pages: 166-170

    • DOI

      10.1159/000355258

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-23591234, KAKENHI-PROJECT-23591694, KAKENHI-PROJECT-24310144, KAKENHI-PROJECT-25461768, KAKENHI-PROJECT-26461733, KAKENHI-PROJECT-26461746
  • [Journal Article] Haploinsufficiency of CSF-1R and Clinicopathological Characterization in patients with HDLS.2014

    • Author(s)
      Konno T, Tada M, Tada M, Koyama A, Nozaki H, Harigaya Y, Nishimiya J, Matsunaga A, Yoshikura N, Ishihara K, Arakawa M, Isami A, Okazaki K, Yokoo H, Itoh K, Yoneda M, Kawamura M, Inuzuka T, Takahashi H, Nishizawa M, Onodera O, Kakita A, Ikeuchi T
    • Journal Title

      Neurology

      Volume: 82 Pages: 139-148

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Journal Article] Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene2013

    • Author(s)
      Shimizu H, Toyoshima Y, Shiga A, Yokoseki A, Arakawa K, Sekine Y, Shimohata T, Ikeuchi T, Nishizawa M, Kakita A, Onodera O, Takahashi H
    • Journal Title

      Acta Neuropathol

      Volume: 126(3) Pages: 453-9

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590390
  • [Journal Article] Extensive aggregation ofα-synuclein and tau in juvenile-onset neuroaxonal dystrophy : an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site2013

    • Author(s)
      Riku Y, Ikeuchi T, Yoshino H, Mimuro M, Mano K, Goto Y, Hattori N, Sobue G, Yoshida M
    • Journal Title

      Acta Neuropathologica Communication

      Volume: 1 Pages: 12-12

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Sporadic ALS with compound heterozygous mutations in the SQSTM1 gene2013

    • Author(s)
      Shimizu H, Toyoshima Y, Yokoseki A, Shiga A, Arakawa K, Sekine Y, Shimohata T, Ikeuchi T, Nishizawa M, Kakita A, Onodera O, Takahashi H.
    • Journal Title

      Acta Neuropathologica

      Volume: 126 Pages: 453-459

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasian2013

    • Author(s)
      Miyashita A, Koike A, Jun G, Wang LS, Takahashi S, Matsubara E, Kawarabayashi T, Shoji M, Tomita N, Arai H, Asada T, Harigaya Y, Ikeda M, Amari M, Hanyu H, Higuchi S, Ikeuchi T, Nishizawa M, Suga M, Kawase Y, Akatsu H, Kosaka K, Yamamoto T, Imagawa M, Hamaguchi T, Yamada M, Moriaha T, Takeda M, Takao T, Nakata K, Fujisawa Y, Sasaki K, Watanabe K, Nakashima K, Urakami K, Ooya T, Takahashi M, Yuzuriha T, Serikawa K, Yoshimoto S, Nakagawa R, Kim JW, Ki CS, Won HH, Na DL, Seo SW, Mook-Jung I; Alzheimer Disease Genetics Consortium, St George-Hyslop P, Mayeux R, Haines JL, Pericak-Vance MA, Yoshida M, Nishida N, Tokunaga K, Yamamoto K, Tsuji S, Kanazawa I, Ihara Y, Schellenberg GD, Farrer LA, Kuwano R
    • Journal Title

      PLOS One

      Volume: 8

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Parkinsonian features in a patient with diffuse neurofibrillary tangles with calcification (DNTC)2012

    • Author(s)
      Ikeuchi T, Katsui T, Kasuga K, Hirose M, Nishizawa M
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 18 Pages: 649-650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Novel G37V mutation of SOD1 gene in autopsied patient with familial amyotrophic lateral sclerosis2012

    • Author(s)
      Kobayashi J, Kuroda M, Kawata A, Mochizuki Y, Mizutani T, Komori T, Ikeuchi T, Koide R
    • Journal Title

      Amyotrophic Lateral Sclerosis

      Volume: 14 Pages: 570-572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] α-Synuclein as CSF and Blood Biomarker of Dementia with Lewy Bodies2012

    • Author(s)
      Kasuga K, Nishizawa M, Ikeuchi T
    • Journal Title

      International Journal of Alzheimer's Disease

      Volume: 437025

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Hyperphosphorylation of tau induced by naturally secreted amyloid-βat low nanomolar concentrations is modulated by insulin-dependent Akt-GSK3βsignaling pathway2012

    • Author(s)
      Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T
    • Journal Title

      Journal of Biological Chemistry

      Volume: 287 Pages: 35222-35233

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Autosomal dominant tauopathy with parkinsonism and central hypoventilation2012

    • Author(s)
      Omoto M, Suzuki S, Ikeuchi T, Ishihara T, Kobayashi T, Tsuboi Y, Ogasawara J, Koga M, Kawai M, Iwaki T, Kanda T
    • Journal Title

      Neurology

      Volume: 78 Pages: 752-764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Parkinsonian features in a patient with diffuse neurofibrillary tangles with calcification (DNTC)2012

    • Author(s)
      Ikeuchi T, Katsui T, Kasuga K, Hirose M, Nishizawa M
    • Journal Title

      Parkinsonism & Related Disorders

      Volume: 18 Pages: 649-650

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Alteredγ-secretase activity in mild cognitive impairment and Alzheimer's disease2012

    • Author(s)
      Kakuda N, Shoji M, Arai H, Furukawa K, Kuwano R, Ikeuchi T, Akazawa K, Yamaguchi H, Murayama S, Nagashima Y, Nagaike K, Ihara Y, Japanese Alzheimer's Disease Neuroimaging Initiative
    • Journal Title

      EMBO Molecular Medicine

      Volume: 4 Pages: 344-352

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Identification of a TPR-like domain in the Nicastrin subunit ofγ-secretase using synthetic antibodies2012

    • Author(s)
      Zhang X, Hoey RJ, Lin G, Koide A, Leung B, Ahn K, Dolios G, Paduch M, Ikeuchi T, Wang R, Li Y, Koide S, Sisodia SS
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Pages: 8534-8539

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Coordinated increase levels of severalγ-secretase product peptides in the CSF of a subpopulation of sporadic Alzheimer's disease subjects2012

    • Author(s)
      Hata S, Taniguchi M, Piao Y, Ikeuchi T, Fagan AM, Holtzman DM, Bateman R, Gandy S, Urakami K, Suzuki T, Japanese Alzheimer's Disease Neuroimaging Initiatives
    • Journal Title

      Molecular Neurodegeneration

      Volume: 7 Pages: 16-16

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Autosomal dominant tauopathy with parkinsonism and central hypoventilation2012

    • Author(s)
      Omoto M, Suzuki S, Ikeuchi T, Ishihara T, Kobayashi T, Tsuboi Y, Ogasawara J, Koga M, Kawai M, Iwaki T, Kanda T
    • Journal Title

      Neurology

      Volume: 78 Pages: 752-764

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Novel G37V mutation of SOD1 gene in autopsied patient with familial amyotrophic lateral sclerosis2012

    • Author(s)
      Kobayashi J, Kuroda M, Kawata A, Mochizuki Y, Mizutani T, Komori T, Ikeuchi T, Koide R
    • Journal Title

      Amyotrophic Lateral Sclerosis

      Volume: 14 Pages: 570-572

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Clinical characteristics and evidence for a common founder in Japanese families with MAPT R406W mutation2011

    • Author(s)
      Ikeuchi T, Imamura T, Kawase Y, Kitade Y, Tokutake T, Yajima R, Tsukie T, Miyashita A, Sugishita M, Kuwano R, Nishizawa M
    • Journal Title

      Dementia Geriatric Cognitive Disorders EXTRA

      Volume: 1 Pages: 267-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Cerebral small-vessel disease protein HTRA1 controls TGF-β1 signaling via cleavage of proTGF-β12011

    • Author(s)
      Shiga A, Nozaki H, Nihonmatsu M, Kawata H, Arima K, Ikeda S, Tanaka A, Nakano I, Ikeuchi T, Nishizawa M, Onodera O
    • Journal Title

      Human Molecular Genetics

      Volume: 20 Pages: 1800-1810

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Genotype-phenotype correlations in early onset ataxia with ocular motor apraxia and hypoalbuminemia2011

    • Author(s)
      Yokoseki A, Ishihara T, Yamada M, Murakami C, Tsuchiya M, Date H, Sato T, Tada M, Ikeuchi T, Tsuji S, Nishizawa M, Onodera O
    • Journal Title

      Brain

      Volume: 134 Pages: 1387-1399

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Evidence for a common founder and clinical characteristics of Japanese families with MAPT R406W mutation2011

    • Author(s)
      Ikeuchi, et al.
    • Journal Title

      Dementia Geriatric Cognitive Disorder EXTRA

      Volume: 1 Pages: 267-275

    • DOI

      10.1159/000331243

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Clinical characteristics and evidence for a common founder in Japanese families with MAPT R406W mutation.2011

    • Author(s)
      Ikeuchi T et al.
    • Journal Title

      Dementia Geriatric Cognitive Disorders EXTRA

      Volume: 1 Pages: 267-275

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Journal Article] Predominant executive cognitive deficit and cerebral white matter lesion in a patient with fragile X-associated tremor/ataxia syndrome (FXTAS)2011

    • Author(s)
      Kasuga K, Ikeuchi T, Arakawa K, Yajima R, Tokugake T, Nishizawa M
    • Journal Title

      Case Reports in Neurology

      Volume: 3 Pages: 118-123

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Long-term disability and prognosis in dentatorubral-pallidoluysian atrophy (DRPLA): a correlation with CAG repeat length2010

    • Author(s)
      Hasegawa A, Ikeuchi T, Koike R, Mataubara N, Tsuchiya M, Nozaki H, Homma A, Idezuka J, Nishizawa M, Onodera O
    • Journal Title

      Movement Disorders

      Volume: 25 Pages: 1694-1700

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, parkinsonism and motor neuron disease : a distinct clinicopathological and biochemical disease entity.2010

    • Author(s)
      Fu Y, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koide R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H.
    • Journal Title

      Acta Neuropathologica 120

      Pages: 21-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease2010

    • Author(s)
      Ikeuchi, et al
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: 30 Pages: 28-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Alzheimer's disease : Report of two autopsy cases with a clinical diagnosis of corticobasal degeneration.2010

    • Author(s)
      Okazaki K, Fu Y-J, Nishihira Y, Endo M, Fukushima T, Ikeuchi T, Okamoto K, Onodera O, Nishizawa M, Takahashi H.
    • Journal Title

      Neuropathology 30

      Pages: 140-148

    • NAID

      10029320298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Involvement of Onuf's nucleus in Machado-Joseph disease2010

    • Author(s)
      Shimizu H, Yamada M, Toyoshima Y, Ikeuchi T, Onodera O, Takahashi H
    • Journal Title

      Acta Neuropathologica

      Volume: 120 Pages: 439-448

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Dementia Geriat Cogn Disord2010

    • Author(s)
      Ikeuchi T, Hirayama S, Miida T, Fukamachi I, Tokutake T, Ebinuma H, Takubo K, Kaneko H, Kasuga K, Kakita A, Takahashi H, Bujo H, Saito Y, Nishizawa M.
    • Journal Title

      30

      Pages: 28-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Alzheimer's disease: Report of two autopsy cases with a clinical diagnosis of corticobasal degeneration2010

    • Author(s)
      Okazaki K, Fu Y-J, Nishihira Y, Endo M, Fukushima T, Ikeuchi T, Okamoto K, Onodera O, Nishizawa M, Takahashi H
    • Journal Title

      Neuropathology

      Volume: 30 Pages: 140-148

    • NAID

      10029320298

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Increased levels of soluble LR11 in cerebrospinal fluid of patients with Alzheimer disease2010

    • Author(s)
      Ikeuchi, et al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: 30 Pages: 28-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Sporadic four-repeat tauopathy with frontotemporal lobar degeneration, parkinsonism and motor neuron disease: a distinct clinicopathological and biochemical disease entity2010

    • Author(s)
      Fu Y, Nishihira Y, Kuroda S, Toyoshima Y, Ishihara T, Shinozaki M, Miyashita A, Piao YS, Tan CF, Tani T, Koide R, Iwanaga K, Tsujihata M, Onodera O, Kuwano R, Nishizawa M, Kakita A, Ikeuchi T, Takahashi H
    • Journal Title

      Acta Neuropathologica

      Volume: 120 Pages: 21-32

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Differential levels of α-synuclein, β-amyloid, and tau in cerebrospinal fluid between patients with dementia with Lewy bodies and Alzheimer disease2010

    • Author(s)
      Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, Nishizawa M, Ikeuchi T
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 81 Pages: 608-610

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Differential levels of α-synuclein, β-amyloid, and tau in cerebrospinal fluid between patients with dementia with Lewy bodies and Alzheimer disease.2010

    • Author(s)
      Kasuga K, Tokutake T, Ishikawa A, Uchiyama T, Tokuda T, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry 81

      Pages: 608-610

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] The 28-amino acid form of an APLP1-derived Aβ-like peptide is a surrogate marker for Aβ42 production in the central nervous system.2009

    • Author(s)
      Yanagida K, Okochi M, Tagami S, Nakayama T, Kodama TS, Nishitomi K, Jiang J, Mori K, Tatsumi S,T Arai T, Ikeuchi T, Kasuga K, Tokuda T, Masaki Kondo M, Masaki Ikeda M, Kentaro Deguchi K, Hiroaki Kazui H, Tanaka T, Morihara T, Hashimoto R, Kudo T, Steiner H, Haass C, Tsuchiya K, Akiyama H, Kuwano R, Takeda M.
    • Journal Title

      EMBO Molecular Medicine 1

      Pages: 223-235

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Identification of independent APP locus duplication in Japanese patients with early-onset Alzheimer disease.2009

    • Author(s)
      Kasuga K, Shimohata T, Nishimura A, Shiga A, Mizuguchi T, Tokunaga J, Ohno T, Miyashita A, Kuwano R, Matsumoto N, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry 80

      Pages: 1050-1052

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Depression and psychiatric symptoms preceding onset of dementia in family with early-onset Alzheimer disease with novel PSEN1-mutation.2009

    • Author(s)
      Kasuga K, Ohno T, Ishihara T, Miyashita A, Kuwano R, Onodera O, Nishizawa M, Ikeuchi T.
    • Journal Title

      Journal of Neurology 256

      Pages: 1351-1353

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Journal Article] Mutational analysis of early-onset familial dementia: role of PSEN1 mutations and MAPT R406W mutation2008

    • Author(s)
      Ikeuchi, et. al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorders (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] Homozygous and heterozygous patients for SNCA duplication in family with parkinsonism and dementia2008

    • Author(s)
      Ikeuchi, T, et. al.
    • Journal Title

      Archives of Neurology 65

      Pages: 514-519

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] Homozygous and heterozygous patients for SNCA duplication in family with parkinsonism and dementia.2007

    • Author(s)
      Ikeuchi T, et. al.
    • Journal Title

      Archives of Neurology 65

      Pages: 514-519

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] PS1 mutation and a-synuclein accumulation2006

    • Author(s)
      Ikeuchi, T, Ishikawa, A
    • Journal Title

      Dementia Japan 20

      Pages: 246-252

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] PS1変異とα-synuclein蓄積2006

    • Author(s)
      池内 健, 石川 厚
    • Journal Title

      Dementia Japan 20

      Pages: 246-252

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] Presenilin2005

    • Author(s)
      Ikeuchi T
    • Journal Title

      Dementia Japan 19(1)

      Pages: 11-20

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] プレセニリン2005

    • Author(s)
      池内 健
    • Journal Title

      Dementia Japan (印刷中)

    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] 痴呆症治療をめぐる戦略:セクレターゼ阻害剤による治療アプローチ2005

    • Author(s)
      池内 健
    • Journal Title

      老年精神医学雑誌 16・増刊号

      Pages: 105-110

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] ブレセニリン2005

    • Author(s)
      池内 健
    • Journal Title

      Dementia Japan 19・1

      Pages: 11-20

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] 群発頭痛からReader症候群に進展し副腎皮質ステロイドが著効した1例2005

    • Author(s)
      池内 健
    • Journal Title

      臨床神経学 45・4

      Pages: 321-323

    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] Therapeutic strategy for Alzheimer disease : Approach by using secretase inhibitors2005

    • Author(s)
      Ikeuchi T
    • Journal Title

      Ronen Seishin Igaku-Zasshi 16

      Pages: 105-110

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] プレセニリン2005

    • Author(s)
      池内 健
    • Journal Title

      Dementia Japan 19・1

      Pages: 11-20

    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] プレセニリン2005

    • Author(s)
      池内 健
    • Journal Title

      Dementia Japan (印刷中)

    • Data Source
      KAKENHI-PROJECT-16015243
  • [Journal Article] 痴呆症治療をめぐる戦略-セクレターゼ阻害剤による治療アプローチ2005

    • Author(s)
      池内 健
    • Journal Title

      老年精神医学雑誌 16・増刊号

      Pages: 105-110

    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] アルツハイマー病:β・γセクレターゼ阻害剤2004

    • Author(s)
      池内 健
    • Journal Title

      BRAIN MEDICAL 16・1

      Pages: 9-15

    • Data Source
      KAKENHI-PROJECT-16015243
  • [Journal Article] アルツハイマー病:β・γセクレターゼ阻害剤2004

    • Author(s)
      池内 健
    • Journal Title

      Brain Medical 16・1

      Pages: 9-15

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] Dementia2004

    • Author(s)
      Ikeuchi T
    • Journal Title

      Molecular medicine 41

      Pages: 322-327

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] 病気はどこまでゲノムで決められているか:痴呆2004

    • Author(s)
      池内 健
    • Journal Title

      Molecular Medicine 41・増刊号

      Pages: 322-327

    • Data Source
      KAKENHI-PROJECT-16015243
  • [Journal Article] アルツハイマー病:β・γセクレターゼ阻害剤2004

    • Author(s)
      池内 健
    • Journal Title

      BRAIN MEDICAL 16・1

      Pages: 9-15

    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] Alzheimer disease : β/γ-secretase inhibitor2004

    • Author(s)
      Ikeuchi, T
    • Journal Title

      Brain Medical 16(1)

      Pages: 9-15

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] 病気はどこまでゲノムで決められているか:痴呆2004

    • Author(s)
      池内 健
    • Journal Title

      Molecular Medicine 41・増刊号

      Pages: 322-327

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-16590816
  • [Journal Article] Mutational analysis in early-onset familial dementia in Japanese population: role of PSEN1 and MAPT R406W mutations

    • Author(s)
      Ikeuchi T, et. al.
    • Journal Title

      Dementia and Geriatric Cognitive Disorders (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Journal Article] Kuwano R. SORL1 is genetically associated with late-onset al.zheimer's disease in Japanese, Koreans and Caucasian

    • Author(s)
      Miyashita A, Koike A, Jun G, (13名略), Ikeuchi T, (42名略)
    • Journal Title

      PLOS One

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Journal Article] Extensive aggregation of α-synuclein and tau in juvenile-onset neuroaxonal dystrophy: an autopsied individual with a novel mutation in the PLA2G6 gene-splicing site

    • Author(s)
      Riku Y, Ikeuchi T, Yoshino H, Mimuro M, Mano K, Goto Y, Hattori N, Sobue G, Yoshida M
    • Journal Title

      Acta Neuropathologica Communication

      Volume: (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 一次性ミクログリア病:病態研究の進歩と新規治療法2020

    • Author(s)
      池内 健
    • Organizer
      第32回日本神経免疫学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Presentation] 中枢性希少難病に対するミクログリアを標的とした新規治療アプローチ2020

    • Author(s)
      池内 健
    • Organizer
      第93回日本薬理学会年会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Presentation] 一次性ミクログリア病の病態から考えるミクログリアを標的とした治療の可能性2020

    • Author(s)
      池内 健
    • Organizer
      第63回日本神経化学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Presentation] 神経軸索スフェロイド形成をともなう遺伝性びまん性白質質脳症 (HDLS)の画像と病理2020

    • Author(s)
      池内 健
    • Organizer
      第61回日本神経学会
    • Invited
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Presentation] CSF1RバリアントのキナーゼアッセイによるCSF1R関連脳症の発症機序解明2020

    • Author(s)
      朱 斌,Liu Lixin,樋口 陽,Yusran Ady Fitrah,三浦 健,目崎直実,原 範和,月江珠緖,今野卓哉,春日健作,宮下哲典,池内 健
    • Organizer
      第39回日本認知症学会学術集会
    • Data Source
      KAKENHI-PROJECT-19H03571
  • [Presentation] Globular glial tauopathy: characteristic histologic features of an autopsied patient with its type II2017

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Shimizu H, Miura T, Ikeuchi T, Takahashi H, Kakita A
    • Organizer
      The 10th Congress of Asia Pacific International Academy of Pathology &
    • Place of Presentation
      Bali (Indonesia)
    • Year and Date
      2017-04-24
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] 分子遺伝学を基盤とした成人発症大脳白質脳症の理解2017

    • Author(s)
      池内 健
    • Organizer
      第36回日本認知症学会
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] Partial loss of autophosphorylation of CSF1R in a patient with familial ischemic cerebrovascular syndrome2017

    • Author(s)
      Konno T, Harriott, Miura T, Mezaki N, Ross OA, Edwards ES, Meschia JF, Ikeuchi T, Wszolek ZK
    • Organizer
      Annual Meeting of American Neurological Association
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] Identification of serum microRNA as a potential biomarker related to the progression of Alzheimer’s disease.2017

    • Author(s)
      Kuwano R, Hara N, Kikuchi M, Miyashita A, Hatsuta H, Saito Y, Kasuga K, Murayama S, Ikeuchi T
    • Organizer
      Alzheimer's Association International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] Identification and functional assay of novel missense mutations of CSF1R in patients with HDLS/ALSP2017

    • Author(s)
      Miura T, Mezaki N, Ishiguro T, Tokutake T, Kasuga K, Konno T, Nozaki H, Onodera O, Ikeuchi T
    • Organizer
      World Congress of Neurology
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] Cognitive dysfunction and movement disorder in adult-onset leukoencephalopathies2017

    • Author(s)
      Ikeuchi T
    • Organizer
      XXII World Congress on Parkinson’s disease and Related Disorders
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Presentation] Age-weighted polygenic risk model effectively predicts the onset of Alzheimer disease.2017

    • Author(s)
      Lee JJ, Kang S, Lee W, Gunasekaran TI, Park JE, Seo H, Park M, Rhee S, Kim H, Kim BC, Choo IH, Ikeuchi T, Choi KY, Lee KH
    • Organizer
      Alzheimer's Association International Conference
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] アルツハイマー病の遺伝因子と臨床的意義2017

    • Author(s)
      池内 健
    • Organizer
      第59回日本老年医学会学術集会
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Presentation] 運動と認知症:最新の疫学研究から見えてきた認知症予防2016

    • Author(s)
      池内 健
    • Organizer
      第6回認知症予防学会
    • Place of Presentation
      東北大学川内萩ホール(宮城県仙台市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] White matter calcifications in adult-onset leukoencephalopathy with axonal spheroids and pigmented glia2016

    • Author(s)
      Konno T, Wszolek Z, Broderick D, Ikeuchi T, Onodera O
    • Organizer
      Keystone Symposia Conference
    • Place of Presentation
      Keystone, Colorado, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] Proposed diagnostic criteria for adult-onset leukoencephalopathy with axonal spheroids and pigmeneted glia2016

    • Author(s)
      Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
    • Organizer
      68th Annual Meeting of American Academy of Neurology
    • Place of Presentation
      Vancouver, Canada
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] 糖尿病の観点から見た認知症の治療・予防戦略2016

    • Author(s)
      池内 健
    • Organizer
      第6回認知症予防学会
    • Place of Presentation
      東北大学川内萩ホール(宮城県仙台市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] Immunohistochemical features of GGT revealed using a tau oligomer-specific antibody2016

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Ikeuchi T, Nishizawa M, Takahashi H, Kakita A
    • Organizer
      11th European Congress of Neuropathology
    • Place of Presentation
      Bordeaux (France)
    • Year and Date
      2016-07-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] ゲノム・遺伝子からみた認知症の病態解明2016

    • Author(s)
      池内 健
    • Organizer
      第57回 日本神経学会学術大会
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Presentation] 遺伝子とバイオマーカー研究がもたらすアルツハイマー病の新しい理解2016

    • Author(s)
      池内 健
    • Organizer
      Alzheimer Academy Japan
    • Place of Presentation
      トレストシティカンファレンス(宮城県仙台市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Presentation] Clinical characterization of Adult-onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia.2016

    • Author(s)
      Konno T, Yoshida K, Mizuno T, Kawarai T, Tada M, Nozaki H, Ikeda S, Nishizawa M, Onodera O, Wszolek ZK, Ikeuchi T
    • Organizer
      141st Annual Meeting of American Neurological Association
    • Place of Presentation
      Baltimore, MD, USA
    • Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-16H01331
  • [Presentation] Immunohistochemical features of tauopathies revealed usiing a tau oligomer-specific antibody.2016

    • Author(s)
      Tanaka H, Toyoshima Y, Tada M, Shimizu H, Shiga A, Ikeuchi T, Takahashi H, Kakita A
    • Organizer
      第57回日本神経病理学会総会学術研究会
    • Place of Presentation
      ホテルニューキャッスル (青森県・弘前市)
    • Year and Date
      2016-06-01
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] アルツハイマー病のプレクリニカル期の診断と治療戦略2015

    • Author(s)
      池内 健
    • Organizer
      BMB2015
    • Place of Presentation
      神戸国際会議場(兵庫県神戸市)
    • Year and Date
      2015-12-04
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] Globular glial tauopathy (type II) clinically mimicking ALS2015

    • Author(s)
      Tanaka H, Toyoshima Y, Miura T, Tada M, Shimizu H, Shiga A, Ikeuchi T, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] 神経軸索ジストロフィーのオーバービュー:臨床と最近の知見.ミクログリアの関与2015

    • Author(s)
      池内 健
    • Organizer
      第34回日本認知症学会
    • Place of Presentation
      リンク青森(青森県青森市)
    • Year and Date
      2015-10-04
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] 世代間で著しい臨床的多様性を呈したHDLS一家系の臨床的および分子遺伝的解析2015

    • Author(s)
      勇亜衣子,目崎直実,徳武孝允,石川正典,三浦 健,今野卓哉,長谷川有香,三瓶一弘,西澤正豊,池内 健
    • Organizer
      第112回日本内科学会
    • Place of Presentation
      みやこメッセ、京都市
    • Year and Date
      2015-04-11
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] 神経軸索ジストロフィーのオーバービュー:臨床と最近の知見.ミクログリアの関与2015

    • Author(s)
      池内 健
    • Organizer
      第56回日本神経学会学術集会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-05-21
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] Globular glial tauopathy:蓄積タウの特徴2015

    • Author(s)
      豊島靖子、竹内亮子、田中英智、他田真理、清水 宏、池内 健、柿田明美、高橋 均
    • Organizer
      第56回日本神経病理学会総会学術研究会
    • Place of Presentation
      九州大学医学部百年講堂、福岡
    • Year and Date
      2015-06-03
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] 認知症治療に向けた新たな病態の理解 糖代謝2015

    • Author(s)
      池内 健
    • Organizer
      第33回日本神経治療学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-11-27
    • Invited
    • Data Source
      KAKENHI-PROJECT-15H04839
  • [Presentation] Globular glial mixed four repeat tau and TDP-43 proteinopathy with motor neuron disease and frontotemporal dementia.2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
    • Organizer
      26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-11
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26250017
  • [Presentation] Globular Glial Mixed Four Repeat Tau and TDP-43 Proteinopathy with Motor Neuron Disease and Frontotemporal Dementia2015

    • Author(s)
      Takeuchi R, Toyoshima Y, Tada M, Shiga A, Miura T, Aoki K, Ikeuchi T, Nishizawa M, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] Tau oligomer accumulation in patients with globular glial tauopathies -type III2015

    • Author(s)
      Toyoshima Y, Tanaka H, Takeuchi R, Shimizu H, Tada M, Shiga A, Yokota O, Kuroda S, Ikeuchi T, Kakita A, Takahashi H
    • Organizer
      The 26th International Symposium on ALS/MND
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-12-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] 認知症の診断学:実際的アプローチと将来展望2015

    • Author(s)
      池内 健
    • Organizer
      第52回 日本リハビリテーション医学会学術集会
    • Place of Presentation
      朱鷺メッセ(新潟県新潟市)
    • Year and Date
      2015-05-29
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K15335
  • [Presentation] 軸索スフェロイド形成を伴うびまん性白質脳症(HDLS)の診断基準案の策定2014

    • Author(s)
      今野卓哉,他田正義,吉田邦広,水野敏樹,野崎洋明,池田修一,西澤正豊,小野寺理,池内 健
    • Organizer
      第33回日本認知症学会
    • Place of Presentation
      パシフィコ横浜、横浜市
    • Year and Date
      2014-11-30
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] Hereditary Diffuse Leukoencephalopathy With Spheroids (HDLS): Histological Features Of Microglia.2014

    • Author(s)
      Tada M, Konno T, Tada M, Okazaki K, Arakawa M,Itoh K, Yamamoto T, Yokoo H, Yoshikura N, Ishihara K, Toyoshima Y, Onodera O,Nishizawa M, Ikeuchi T, Takahashi H, Kakita A
    • Organizer
      66th Meeting American Academy of Neurology
    • Place of Presentation
      Pennsylvania Convention Center, Philadelphia, USA
    • Year and Date
      2014-04-28
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] CSF-1R変異陽性・HDLS患者の臨床・画像所見の特徴:診断基準(案)の策定に向けて2014

    • Author(s)
      池内 健
    • Organizer
      第55回日本神経学会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      2014-05-21
    • Invited
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] HDLSはCSF-1Rの機能喪失で生じる -シグナル伝達障害とハプロ不全-2014

    • Author(s)
      勇亜衣子,今野卓哉,他田正義,他田真理,小山哲秀,野崎洋明,金田大太,田代裕一,山本徹,高橋均,西澤正豊,小野寺理,柿田明美,池内 健
    • Organizer
      第55回日本神経学会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      2014-05-24
    • Data Source
      KAKENHI-PUBLICLY-26117506
  • [Presentation] 代謝恒常性の破綻によるアルツハイマー病の発症機序と新規治療法開発2013

    • Author(s)
      池内健
    • Organizer
      第3回日本認知症予防学会
    • Place of Presentation
      新潟市
    • Year and Date
      2013-09-29
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] An emerging role of insulin resistance in amyloid-beta cascade hypothesis2013

    • Author(s)
      Ikeuchi T
    • Organizer
      The 20th IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2013-06-24
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病の未病診断2013

    • Author(s)
      池内健
    • Organizer
      第32回分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2013-12-03
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] 細胞特異的なゲノム高次構造解析法の検討2013

    • Author(s)
      長谷川 舞衣, 原 範和, 菊地 正隆, 宮下 哲典, 中谷 明弘, 池内 健, 桑野 良三
    • Organizer
      第36回日本分子生物学会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-24310144
  • [Presentation] 神経軸索スフェロイドを伴う白質脳症HDLSの臨床・遺伝学的解析2013

    • Author(s)
      他田正義,今野卓哉,他田真理,荒川武蔵,小山哲秀,野崎洋明,針谷康夫,西宮仁,松永晶子,米田誠,吉倉延亮,犬塚貴,石原健司,河村満,高橋均,小野寺理,西澤正豊,池内 健
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 神経軸索スフェロイドを伴う白質脳症HDLSにおけるCSF-1Rシグナル伝達異常の解析2013

    • Author(s)
      今野卓哉,他田正義,小山哲秀,他田真理,荒川武蔵,野崎洋明,針谷康夫,西宮仁,松永晶子,米田誠,吉倉延亮,犬塚貴,石原健司,河村満,高橋均,小野寺理,西澤正豊,池内 健
    • Organizer
      第54回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2013-05-31
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 晩期発症型アルツハイマー病とTREM2の関連解析2013

    • Author(s)
      宮下哲典, 温雅楠, 初田裕幸, 村山繁雄, 山口晴保, 赤津裕康, 柿田明美, 高橋均, 井原康夫, 池内健, 桑野良三
    • Organizer
      第32回日本認知症学会
    • Place of Presentation
      長野県松本市
    • Data Source
      KAKENHI-PROJECT-24510275
  • [Presentation] Hyperphosphorylation of tau induced by naturally secreted amyloid-βat low nanomolar concentrations is mediated by insulin-dependent signaling pathway2012

    • Author(s)
      Tokutake T, Kasuga K, Yajima R, Sekine Y, Tezuka T, Nishizawa M, Ikeuchi T
    • Organizer
      Society for Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2012-10-16
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] Aβにより生じるタウリン酸化はインスリン依存性Akt-GSK3βシグナル障害が関連する2012

    • Author(s)
      徳武孝允,手塚敏之,関根有美,矢島隆二,春日健作,西澤正豊,池内健
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば市(ポスター発表)
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] 脳アミロイドアンギオパチー関連炎症の臨床的多様性:画像所見,APOE,血中Aβ抗体2012

    • Author(s)
      須貝章弘,石井賢二,赤岩靖久,本間篤,藤田信也,田中晋,豊原潤,石渡喜一,西澤正豊,池内 健
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば市
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] βアミロイド依存性タウ・リン酸化におけるインスリン抵抗性の関与:初代神経培養細胞を用いた共培養による解析2012

    • Author(s)
      徳武孝允,池内健,春日健作,矢島隆二,西澤正豊
    • Organizer
      第53回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] リポタンパク受容体LR11によるアポリポ蛋白E(ApoE)アイソフォーム依存性の調節機構2012

    • Author(s)
      西野香織,矢島隆二,徳武孝允,手塚敏之,西澤正豊,池内 健
    • Organizer
      第35回分子生物学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-14
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 若年性認知症を呈する白質脳症:HDLS患者のCSF1R変異,MRI所見,臨床像,病理像の検討2012

    • Author(s)
      今野卓哉,他田正義,小山哲秀,荒川武蔵,岡崎健一,柿田明美,高橋均,西澤正豊,小野寺理,池内 健
    • Organizer
      第31回日本認知症学会
    • Place of Presentation
      つくば市
    • Year and Date
      2012-10-26
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] Late Breaking Symposium「新たな若年性認知症:神経軸索ジストロフィーを伴う遺伝性白質脳症(HDLS).HDLSの分子病態と白質を主病変とする他疾患との異常2012

    • Author(s)
      池内 健
    • Organizer
      第53回 日本神経学会学術大会.
    • Place of Presentation
      東京
    • Year and Date
      2012-05-25
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 共培養システムを用いたβアミロイド依存性タウリン酸化の解析:インスリンシグナル伝達障害の関与2011

    • Author(s)
      徳武孝允,春日健作,矢島隆二,西澤正豊,池内健
    • Organizer
      第30回日本認知症学会
    • Place of Presentation
      東京(ポスター発表)
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病患者・髄液中における可溶性LR11の増加2011

    • Author(s)
      池内健,他
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] β-amyloid induced hyperphosphorylation of tau : possible involvement of insulin signal dysfunction2011

    • Author(s)
      Tokutake T, Kasuga K, Yajima R, Nishizawa M, Ikeuchi T
    • Organizer
      Alzheimer's Association International Conference
    • Place of Presentation
      Paris, France
    • Year and Date
      2011-07-20
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] βアミロイドによる誘発されるタウリン酸化におけるインスリンシグナル障害の関与2011

    • Author(s)
      徳武孝允,池内 健,春日健作,矢島隆二,石原智彦,西澤正豊
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] βアミロイドによる誘発されるタウリン酸化におけるインスリンシグナル障害の関与2011

    • Author(s)
      徳武孝允,池内健,春日健作,矢島隆二,石原智彦,西澤正豊
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋(口演発表)
    • Year and Date
      2011-05-19
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病の発症機構における糖尿病の関与2011

    • Author(s)
      池内健
    • Organizer
      第30回認知症学会.シンポジウム5「生活習慣病と認知症」
    • Place of Presentation
      東京
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病の発症機構における糖尿病の関与2011

    • Author(s)
      池内健
    • Organizer
      第30回日本認知症学会(招待講演)
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病患者・髄液中における可溶性LR11の増加2011

    • Author(s)
      池内 健,平山哲,三井田孝,深町勇,矢島隆二,徳武孝允,金子博之,春日健作,海老沼宏幸,田久保耕平,武城英明,西澤正豊
    • Organizer
      第52回日本神経学会
    • Place of Presentation
      名古屋
    • Year and Date
      2011-05-20
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] アルツハイマー病の発症機構における糖尿病の関与2011

    • Author(s)
      池内健
    • Organizer
      第30回日本認知症学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-11
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] APOEε4(+)群とε4(-)群との臨床経過,側頭葉内側部萎縮,髄液バイオマーカーの比較2010

    • Author(s)
      矢島隆二, 池内健, 春日健作, 徳武孝允, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-22
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] レビー小体型認知症(DLB)の新規バイオマーカー:髄液αシヌクレインのELISA定量2010

    • Author(s)
      徳武孝允,春日健作,矢島隆二,石川厚,内山剛,徳田隆彦,西澤正豊,池内 健
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] アルツハイマー病患者・髄液中では可溶性LR11が増加する2010

    • Author(s)
      池内健, 平山哲, 三井田孝, 深町勇, 矢島隆二, 徳武孝允, 春日健作, 金子博之, 田久保耕平, 海老沼宏幸, 武城英明, 西澤正豊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] レビー小体型認知症(DLB)の新規バイオマーカー:髄液αシヌクレインのELISA定量2010

    • Author(s)
      徳武孝允, 春日健作, 矢島隆二, 石川厚, 内山剛, 徳田隆彦, 西澤正豊, 池内健
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] βアミロイド依存性タウリン酸化カスケードにおけるインスリンシグナル障害の関与2010

    • Author(s)
      徳武孝允,池内 健,春日健作,篠崎 真,小野寺理,西澤正豊
    • Organizer
      第51回日本神経学会 2
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] アルツハイマー病患者・髄液中では可溶性LR11が増加する2010

    • Author(s)
      池内 健,平山哲,三井田孝,深町勇,矢島隆二,徳武孝允,春日健作,金子博之,田久保耕平,海老沼宏幸,武城英明,西澤正豊
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 健忘主体の臨床徴候を呈するタウ遺伝子R406W変異を伴う家族性認知症2010

    • Author(s)
      池内健, 他
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京フォーラム(東京都)
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 健忘主体の臨床徴候を呈するタウ遺伝子R406W変異を伴う家族性認知症2010

    • Author(s)
      池内 健,春日健作,宮下哲典,川瀬康裕,杉下守弘,桑野良三,西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] βアミロイド依存性タウリン酸化カスケードにおけるインスリンシグナル障害の関与2010

    • Author(s)
      徳武孝允, 池内健, 春日健作, 篠崎真, 小野寺理, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      東京
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 遺伝子変異を伴った家族性アルツハイマー病の表現型の比較2010

    • Author(s)
      池内健, 他
    • Organizer
      第50回日本神経学会
    • Place of Presentation
      仙台国際センター (宮城県)
    • Year and Date
      2010-05-24
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 健忘主体の臨床徴候を呈するタウ遺伝子R406W変異を伴う家族性認知症2010

    • Author(s)
      池内健, 春日健作, 宮下哲典, 川瀬康裕, 杉下守弘, 桑野良三, 西澤正豊
    • Organizer
      第51回日本神経学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-20
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] アルツハイマー病患者・髄液中では可溶型LR11が増加する2010

    • Author(s)
      池内健, 他
    • Organizer
      第29回日本認知症学会学術集会
    • Place of Presentation
      名古屋市
    • Year and Date
      2010-11-05
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] アルツハイマー病関連・βアミロイド(Aβ)配列内変異がAβ産生および高次構造に及ぼす影響2009

    • Author(s)
      篠崎真, 金子博之, 春日健作, 徳武孝允 ,小野寺理, 西澤正豊, 池内健
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 健忘主体の特異な臨床型を呈したタウ遺伝子(MAPT)R406W変異を伴う家族性認知症の臨床分子遺伝子学的解析2009

    • Author(s)
      池内健, 春日健作, 宮下哲典, 川瀬康裕, 小野寺理, 杉下守弘, 桑野良三, 西澤正豊
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-21
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] レビー小体の大脳皮質におけるαシヌクレイン蓄積とSNCAmRNA発現の検討2009

    • Author(s)
      野崎洋明, 石平悠, 金子博之, 豊島靖子, 柿田明美, 高橋均, 小野寺理, 西澤正豊, 池内健
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-21
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] Aβはインスリンシグナルを障害することでタウの過剰リン酸化を引き起こすか?2009

    • Author(s)
      春日健作, 徳武孝允, 篠崎真, 西澤正豊, 小野寺理, 池内健
    • Organizer
      第28回日本認知症学会
    • Place of Presentation
      仙台
    • Year and Date
      2009-11-20
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 健忘主体な特異な臨床型を呈したタウ遺伝子(MAPT)R406W変異を伴う家族性認知症の臨床分子遺伝学的解析2009

    • Author(s)
      池内健, 他
    • Organizer
      第28回日本認知症学会学術集会
    • Place of Presentation
      東北大学百周年記念会館(宮城県)
    • Year and Date
      2009-11-21
    • Data Source
      KAKENHI-PROJECT-21200041
  • [Presentation] 遺伝子変異を伴った家族性アルツハイマー病の表現形の比較2009

    • Author(s)
      池内健, 春日健作, 野崎洋明, 石原智彦, 金子博之, 篠崎真, 桑野良三, 小野寺理, 西澤正豊
    • Organizer
      第50回日本神経学会口演発表
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-22
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] 認知症性疾患の髄液バイオマーカーとしてのαシヌクレインの検討2009

    • Author(s)
      春日健作, 池内健, 石川厚, 徳田隆彦, 中川正法, 小野寺理, 西澤正豊
    • Organizer
      第50回日本神経学会口演発表
    • Place of Presentation
      仙台
    • Year and Date
      2009-05-24
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] プレセニリン1変異による難溶性αシヌクレイン蓄積の分子機序2008

    • Author(s)
      池内健, 他
    • Organizer
      49回日本神経学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2008-05-17
    • Data Source
      KAKENHI-PROJECT-20590990
  • [Presentation] Mutational analysis of early-onset Alzheimer disease in Japanese population revealed PSEN1 mutations, MAPT mutation, and APP duplication2007

    • Author(s)
      Ikeuchi T, et. al.
    • Organizer
      International Psychogeriatrics Association Osaka Meeting
    • Place of Presentation
      Osaka, Japan
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Presentation] Mutational analysis of early-onset Alzheimer disease in Japanese population revealed PSEN1 mutations, MAPT mutation, and APP duplication2007

    • Author(s)
      Ikeuchi T, et. al.
    • Organizer
      International Psychogeriatrics Association Osaka Meeting
    • Place of Presentation
      Osaka
    • Year and Date
      2007-10-18
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Presentation] Insulin receptor undergoes presenilin/γ-secretase dependent processing to generate soluble intracellular domain.2007

    • Author(s)
      Kasuga K, Ikeuchi T, et. al.
    • Organizer
      37th Annual Meeting Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-05
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Presentation] Presenilin-1 Mutant, ΔT440, Enhances Accumulation of Phosphorylated α-Synuclein in Culture Cells and Autopsied Brain2007

    • Author(s)
      Kaneko H, Ikeuchi T, et. al.
    • Organizer
      37th Annual Meeting Society for Neuroscience
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2007-11-06
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-18590930
  • [Presentation] An emerging role of insulin resistance in amyloid-beta cascade hypothesis

    • Author(s)
      Takeshi Ikeuchi
    • Organizer
      IAGG World Congress of Gerontology and Geriatrics
    • Place of Presentation
      Seoul, South Korea
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] Genes associated with the progression of neurofibrillary tangles in Alzheimer’s disease brains

    • Author(s)
      Miyashita A, Kuwano R, Hatsuta H, Kikuchi M, Nakaya A, Saito Y, Tsukie T, Hara N, Ogishima S, Kakita A, Takahashi H, Murayama S, Ihara, Ikeuchi T
    • Organizer
      AAIC
    • Place of Presentation
      Bella Center, Copenhagen, Denmark
    • Year and Date
      2014-07-11 – 2014-07-17
    • Data Source
      KAKENHI-PROJECT-24310144
  • [Presentation] 代謝恒常性の破綻によるアルツハイマー病の発症機序と新規治療法開発

    • Author(s)
      池内 健
    • Organizer
      日本認知症予防学会
    • Place of Presentation
      新潟市
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] アルツハイマー病の未病診断

    • Author(s)
      池内 健
    • Organizer
      日本分子生物学会
    • Place of Presentation
      神戸市
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] HDLSの分子病態と白質を主病変とする他疾患との鑑別

    • Author(s)
      池内 健
    • Organizer
      第53回 日本神経学会学術集会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-23591234
  • [Presentation] 細胞特異的な遺伝子発現は染色体高次構造の影響を受けるのか?

    • Author(s)
      菊地正隆, 長谷川舞衣, 原 範和, 宮下哲典, 中谷明弘, 池内健, 桑野良三
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2014-11-25 – 2014-11-27
    • Data Source
      KAKENHI-PROJECT-24310144
  • [Presentation] Astrocyteのタウ病理に注目したPSP関連タウオパチーの連続性について

    • Author(s)
      横山裕一、豊島靖子、志賀篤、池内健、長谷川一子、柿田明美、高橋均
    • Organizer
      第55回日本神経病理学会総会学術研究会
    • Place of Presentation
      東京 学術総合センター
    • Year and Date
      2014-06-05 – 2014-06-07
    • Data Source
      KAKENHI-PROJECT-26430052
  • [Presentation] アルツハイマー病における生体分子間ネットワーク解析手法の提案

    • Author(s)
      菊地正隆, 原範和, 宮下哲典, 初田裕幸, 齊藤祐子, 村山繁雄, 池内健, 桑野良三
    • Organizer
      日本認知症学会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2014-11-27 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-24310144
  • [Presentation] ヒト剖検脳を用いたアルツハイマー病関連マイクロRNAの解析.

    • Author(s)
      原範和、菊地正隆、宮下哲典、初田裕幸、齊藤祐子、村山 繁雄、赤津裕康、池内健、桑野良三
    • Organizer
      日本認知症学会
    • Place of Presentation
      横浜パシフィコ
    • Year and Date
      2014-11-29 – 2014-12-01
    • Data Source
      KAKENHI-PROJECT-24310144
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