KAMINO HIROKI 加美野宏樹

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KAMINO Hiroki 加美野宏樹

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Researcher Number	00625692
Other IDs
Affiliation (Current)	2025: 島根大学, 学術研究院機能強化推進学系, 准教授
Affiliation (based on the past Project Information) *help	2024 – 2025: 島根大学, 学術研究院機能強化推進学系, 准教授 2022 – 2023: 島根大学, 医学部, 特別協力研究員 2020 – 2021: 島根大学, 学術研究院医学・看護学系, 特任助教 2015: 国立研究開発法人国立がん研究センター, 研究所, 研究員 2014: 国立がん研究センター, 研究所, 研究員 2013 – 2014: 独立行政法人国立がん研究センター, 研究所, 研究員
Review Section/Research Field	Principal Investigator Basic Section 47050:Environmental and natural pharmaceutical resources-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Tumor biology Except Principal Investigator Basic Section 54020:Connective tissue disease and allergy-related / Tumor biology / Carcinogenesis
Keywords	Principal Investigator 抗体療法 / Interleukin-18 / 膵がん / Pancreatic cancer / IL-18 / 5-フルオロウラシル（5-FU） / 阻害抗体 / 膵臓がん / インターロイキン18（IL-18） / 活性酸素種 / ミトコンドリア / p53 … More Except Principal Investigator … More ミトコンドリア / p53 / マクロファージ活性化症候群 / IL-18 / 難治性炎症疾患 / 抗体治療 / 炎症性サイトカイン / 間質性肺炎 / 抗IL-18活性化断端抗体 / インターロイキン-18 / 活性型 IL-18 測定キット / バイオ医薬品 / 潰瘍性大腸炎 / クローン病 / 炎症性腸炎 / 機能阻害抗体 / インターロイキン-18（IL-18） / APCMin/+マウス / 大腸がん / ApcMin/+マウス / がん / 腫瘍抑制 / ROS / がん抑制 / がん浸潤転移 / ミトコンドリア品質管理 / リソソーム / 酸化ストレス / タンパク質分解 / ゲノム不安定性 Less

ショウガの持つIL-18活性化阻害の作用機序解明と医療応用に向けた基礎研究Principal Investigator
- Principal Investigator
  
  加美野宏樹
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47050:Environmental and natural pharmaceutical resources-related
- Research Institution
  Shimane University
マクロファージ活性化症候群の新しいマウスモデルの作製と治療応用に向けた研究
- Principal Investigator
  
  杉浦智子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
Basic research on antibody therapy against inflammatory cytokine IL-18 for refractory inflammatory diseases
- Principal Investigator
  
  Urano Takeshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54020:Connective tissue disease and allergy-related
- Research Institution
  Shimane University
Development of novel pancreatic cancer treatment using IL-18 inhibitory antibodyPrincipal Investigator
- Principal Investigator
  
  KAMINO Hiroki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Shimane University
Analysis of p53/Mieap pathway in primary human cancer tissuesPrincipal Investigator
- Principal Investigator
  
  Kamino Hiroki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Potential role of the Mieap-regulated mitochondrial quality control in murine intestinal tumorigenesis
- Principal Investigator
  
  Nakamura Yasuyuki
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Tumor biology
- Research Institution
  National Cancer Center Japan
Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria
- Principal Investigator
  
  ARAKAWA Hirofumi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Carcinogenesis
- Research Institution
  National Cancer Center Japan

All 2024 2023 2022 2021 2020 2016 2014 2013 Other

All Journal Article Presentation Patent

[Journal Article] Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function2024
- Author(s)
  Mu Jingxi、Maeda Keiko、Ohashi Ayako、Urano Takeshi、Nariai Yuko、Kamino Hiroki、Nakamura Masanao、Yamamura Takeshi、Sawada Tsunaki、Ishikawa Eri、Murate Kentaro、Yamamoto Kenta、Hirose Takashi、Furukawa Kazuhiro、Fujishiro Mitsuhiro、Kawashima Hiroki
- Journal Title
  
  Digestive Diseases and Sciences
  
  Volume: - Issue: 7 Pages: 2573-2585
- DOI
  10.1007/s10620-024-08453-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753
[Journal Article] Generation of the novel anti-FXYD5 monoclonal antibody and its application to the diagnosis of pancreatic and lung cancer2023
- Author(s)
  Hotta Takamasa、Nariai Yuko、Kajitani Naoyo、Kadota Kyuichi、Maruyama Riruke、Tajima Yoshitsugu、Isobe Takeshi、Kamino Hiroki、Urano Takeshi
- Journal Title
  
  Biochimie
  
  Volume: - Pages: 160-169
- DOI
  10.1016/j.biochi.2023.01.002
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753
[Journal Article] Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases2022
- Author(s)
  Uchida Yuki、Nariai Yuko、Obayashi Eiji、Tajima Yoshitsugu、Koga Tomohiro、Kawakami Atsushi、Urano Takeshi、Kamino Hiroki
- Journal Title
  
  Archives of Biochemistry and Biophysics
  
  Volume: 727 Pages: 109322-109322
- DOI
  10.1016/j.abb.2022.109322
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K06049, KAKENHI-PROJECT-21K08438, KAKENHI-PROJECT-21K08753, KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20K16443
[Journal Article] Kinetics of Anti-SARS-CoV-2 Antibody Response Following Two Doses of the BNT162b2 mRNA Vaccine: A Japanese Single-Center Primary Care Clinic Report Involving Volunteers and Patients with Autoimmune Disease2022
- Author(s)
  Sugiura Tomoko、Sugiura Hiroaki、Kato Hiroaki、Nariai Yuko、Mizumoto Yuuki、Hanada Kozue、Takahashi Rieko、Hinotubo Yukari、Tanaka Naoko、Sasaki Mutsumi、Eguchi Haruki、Kamino Hiroki、Urano Takeshi
- Journal Title
  
  Infectious Disease Reports
  
  Volume: 15 Issue: 1 Pages: 24-33
- DOI
  10.3390/idr15010003
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K05505, KAKENHI-PROJECT-20K07635, KAKENHI-PUBLICLY-21H00255
[Journal Article] Screening of a Panel of Low Molecular Weight Compounds That Inhibit Synovial Fibroblast Invasion in Rheumatoid Arthritis2020
- Author(s)
  Sugiura Tomoko、Kamino Hiroki、Nariai Yuko、Murakawa Yohko、Kondo Masahiro、Kawakami Makoto、Ikeda Noboru、Uchio Yuji、Urano Takeshi
- Journal Title
  
  The Journal of Immunology
  
  Volume: 205 Issue: 12 Pages: 3277-3290
- DOI
  10.4049/jimmunol.1901429
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20H01007
[Journal Article] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers2020
- Author(s)
  Sano Hitoya、Futamura Manabu、Gaowa Siqin、Kamino Hiroki、Nakamura Yasuyuki、Yamaguchi Kazuya、Tanaka Yoshihiro、Yasufuku Itaru、Nakakami Akira、Arakawa Hirofumi、Yoshida Kazuhiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 529 Issue: 3 Pages: 582-589
- DOI
  10.1016/j.bbrc.2020.05.168
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07635, KAKENHI-PROJECT-20K08954, KAKENHI-PROJECT-20K20305, KAKENHI-PROJECT-19K07655
[Journal Article] Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer.2016
- Author(s)
  Kamino H, Nakamura Y, Tsuneki M, Sano H, Miyamoto Y, Kitamura N, Futamura M, Kanai Y, Taniguchi H, Shida D, Kanemitsu Y, Moriya Y, Yoshida K, Arakawa H.
- Journal Title
  
  Oncogenesis
  
  Volume: 4 Issue: 1 Pages: e181-e181
- DOI
  10.1038/oncsis.2015.43
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K15093, KAKENHI-PROJECT-25430124, KAKENHI-PROJECT-25430125
[Patent] 活性型ＩＬ－１８検出キット、及び検査方法2023
- Inventor(s)
  浦野健、加美野宏樹、成相裕子、川上純、古賀智裕、他
- Industrial Property Rights Holder
  浦野健、加美野宏樹、成相裕子、川上純、古賀智裕、他
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2023-195765
- Filing Date
  2023
- Data Source
  KAKENHI-PROJECT-21K08438
[Patent] ワクチン組成物2021
- Inventor(s)
  勝又徹、浦野健、成相裕子、加美野宏樹、秋吉一成、他
- Industrial Property Rights Holder
  旭化成（株）、島根大学、京都大学、三重大学、長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-559206
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-21K08438
[Patent] 活性型インターロイキンー１８タンパク質のネオエピトープを認識する抗体、及びその応用2021
- Inventor(s)
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Holder
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K07635
[Patent] 活性型インターロイキンー１８タンパク質のネオエピトープを認識する抗体、及びその応用2021
- Inventor(s)
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Holder
  株式会社 mAbProtein
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Acquisition Date
  2021
- Data Source
  KAKENHI-PROJECT-21K08438
[Patent] ワクチン組成物2021
- Inventor(s)
  加美野宏樹、成相裕子、浦野健（他６人）
- Industrial Property Rights Holder
  旭化成（株）、島根大学、京都大学、三重大学、長崎大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2021-204470
- Filing Date
  2021
- Data Source
  KAKENHI-PROJECT-20K07635
[Patent] 活性型インターロイキンー１８タンパク質のネオエピトープを認識する抗体、及びその応用2021
- Inventor(s)
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Holder
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Type
  特許
- Filing Date
  2021
- Overseas
- Data Source
  KAKENHI-PROJECT-20K07635
[Patent] 活性型インターロイキンー１８タンパク質のネオエピトープを認識する抗体、及びその応用2020
- Inventor(s)
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Holder
  浦野健、成相裕子、加美野宏樹、尾林栄治
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-559206
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-20K07635
[Presentation] ヒト活性型IL-18を高感度に検出する新規ELISAの開発とその応用2023
- Author(s)
  加美野宏樹、成相裕子、前田啓子、川嶋啓揮、浦野健
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08438
[Presentation] ヒト膵がん細胞株MIA PaCa-2は栄養飢餓によりインターロイキン-18活性化を伴うパイロトーシスを誘導し、この現象は抗がん剤5-フルオロウラシルによって増強される2022
- Author(s)
  加美野宏樹、田島義証、浦野健
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-20K07635
[Presentation] ヒト膵がん細胞株MIA PaCa-2は栄養飢餓によりインターロイキン-18活性化を伴うパイロトーシスを誘導し、この現象は抗がん剤5-フルオロウラシルによって増強される2022
- Author(s)
  加美野宏樹、田島義証、浦野健
- Organizer
  第45回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-21K08438
[Presentation] 活性化型マウスIL-18のネオエピトープに対する機能阻害モノクローナル抗体の作製とその評価方法の開発2022
- Author(s)
  成相裕子、内田有紀、尾林栄治、田島義証、古賀智裕、川上純、浦野健、加美野宏樹
- Organizer
  第95回日本生化学会大会
- Data Source
  KAKENHI-PROJECT-20K07635
[Presentation] 活性化型マウスIL-18のネオエピトープに対する機能阻害モノクローナル抗体の作製とその評価方法の開発2022
- Author(s)
  成相裕子, 内田有紀, 尾林栄治, 田島義証, 古賀智裕, 川上純, 浦野健, 加美野宏樹
- Organizer
  第95回日本生化学会
- Data Source
  KAKENHI-PROJECT-21K08438
[Presentation] フルオロウラシル処理は低栄養培養下での膵がん細胞におけるIL-18活性化を増強する2021
- Author(s)
  加美野宏樹、内田有紀、田島義証、浦野健
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K08438
[Presentation] フルオロウラシル処理は低栄養培養下での膵がん細胞におけるIL-18活性化を増強する2021
- Author(s)
  加美野宏樹、内田有紀、田島義証、浦野健
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07635
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer2014
- Author(s)
  Hiroki Kamino, Yasuyuki Nakamura, Hitoya Sano, Ryuya Murai, Yuri Saito, Manabu Futamura, Kazuhiro Yoshida, Nobuyuki Hiraoka, Yae Kanai, Ryoji Kushima, Toyomasa Katagiri, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego（USA）
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer2014
- Author(s)
  Hiroki Kamino, Yasuyuki Nakamura, Hitoya Sano, Ryuya Murai, Yuri Saito, Manabu Futamura, Kazuhiro Yoshida, Nobuyuki Hiraoka, Yae Kanai, Ryoji Kushima, Toyomasa Katagiri, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego (USA)
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] マウス消化管腫瘍の発生及び進展におけるMieap制御性ミトコンドリア品質管理機構の役割2014
- Author(s)
  中村康之、喜多村憲章、加美野宏樹、佐野仁哉、荒川博文
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜パシフィコ（横浜）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Specific role of Mieap alpha in Mieap-induced vacuole generation through an interaction with UVRAG2014
- Author(s)
  Yasuyuki Nakamura, Hiroki Kamino, Yuri Saito, Noriaki Kitamura, Hitoya Sano, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego（USA）
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] p53-dependent and independent functions of Mieap2014
- Author(s)
  Yasuyuki Nakamura, Hiroki Kamino, Yuri Saito, Hitoya Sano, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego（USA）
- Year and Date
  2014-04-07
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] マウス消化管腫瘍の発生及び進展におけるMieap制御性ミトコンドリア品質管理機構の役割2014
- Author(s)
  中村康之、喜多村憲章、加美野宏樹、佐野仁哉、荒川博文
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  パシフィコ横浜（横浜）
- Year and Date
  2014-09-26
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Specific role of Mieap alpha in Mieap-induced vacuole generation through an interaction with UVRAG2014
- Author(s)
  Yasuyuki Nakamura, Hiroki Kamino, Yuri Saito, Noriaki Kitamura, Hitoya Sano, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego (USA)
- Year and Date
  2014-04-06
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] p53-dependent and independent functions of Mieap2014
- Author(s)
  Yasuyuki Nakamura, Hiroki Kamino, Yuri Saito, Hitoya Sano, Hirofumi Arakawa.
- Organizer
  AACR Annual Meeting 2014
- Place of Presentation
  San Diego (USA)
- Year and Date
  2014-04-07
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in colorectal cancer2013
- Author(s)
  加美野宏樹、中村康之、喜多村憲章、二村学、吉田将紀、村井竜也、齋藤有理、佐野仁哉、金井弥栄、森谷宜皓、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  アメリカ(ワシントン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap誘導性液胞様構造物の形成におけるUVRAGとの結合を介したMieap αの役割について2013
- Author(s)
  加美野宏樹、中村康之、喜多村憲章、宮本崇史、吉田将紀、斉藤有理、佐野仁哉、平岡伸介、金井弥栄、九嶋亮治、荒川博文
- Organizer
  第7回オートファジー研究会
- Place of Presentation
  掛川市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer (膵臓がん及び乳がんで見られるMieap によるミトコンドリア品質管理機構の破綻とその意義ついて)2013
- Author(s)
  加美野宏樹、中村康之、佐野仁哉、村井竜也、齋藤有理、二村学、吉田和弘、平岡伸介、金井弥栄、九嶋亮治、荒川博文
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control in mouse intestinal tumorigenesis (Mieapノックアウトマウスの解析について)2013
- Author(s)
  中村康之、加美野宏樹、佐野仁哉、村井竜也、齋藤有理、荒川博文
- Organizer
  平成25年度文科省科研費新学術領域研究『がん研究分野の特性等を踏まえた支援活動』がん若手研究者ワークショップ
- Place of Presentation
  茅野市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer2013
- Author(s)
  加美野宏樹
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Hypoxia induces accumulation of lysosomal proteins within mitochondria2013
- Author(s)
  中村康之、吉田将紀、喜多村憲章、加美野宏樹、村井竜也、齋藤有理、佐野仁哉、荒川博文
- Organizer
  Cell Symposia 2013 Mitochondria
- Place of Presentation
  ポルトガル(リスボン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Critical role of Mieap in sperm motility through mitochondrial quality control2013
- Author(s)
  斎藤有理、中村康之、加美野広樹、佐野仁哉、吉田将紀、村井竜也、荒川博文
- Organizer
  International Symposium on Mitochondoria 2013
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in different types of cancer2013
- Author(s)
  加美野宏樹
- Organizer
  がん若手研究者ワークショップ
- Place of Presentation
  蓼科
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control in mouse intestinal tumorigenesis2013
- Author(s)
  中村康之、加美野広樹、佐野仁哉、吉田将紀、村井竜也、斉藤有理、荒川博文
- Organizer
  International Symposium on Mitochondoria 2013
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Physiological roles of the Mieap-regulated mitochondrial quality control2013
- Author(s)
  中村康之、加美野宏樹、佐野仁哉、村井竜也、齋藤有理、小池正人、内山安男、荒川博文
- Organizer
  第7回オートファジー研究会
- Place of Presentation
  掛川市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer2013
- Author(s)
  加美野宏樹
- Organizer
  International Symposium on Mitochondria 2013
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Hypoxia induces accumulation of lysosomal proteins within mitochondria2013
- Author(s)
  中村康之、加美野宏樹、喜多村憲章、宮本裕士、佐野仁哉、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  アメリカ(ワシントン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control pathway in gastric tumor suppression2013
- Author(s)
  佐野仁哉、中村康之、加美野広樹、二村学、吉田和弘、荒川博文
- Organizer
  The 4th Japanese Cancer Association - American Association for Cancer Research Special Joint Conference
- Place of Presentation
  千葉市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control in mouse intestinal tumorigenesis (マウス消化管腫瘍の発生と進展におけるMieap制御性ミトコンドリア品質管理機構の役割について)2013
- Author(s)
  中村康之、加美野宏樹、佐野仁哉、村井竜也、齋藤有理、荒川博文
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] 様々ながんで見られるMieapによるミトコンドリア品質管理機構の破綻とその意義について2013
- Author(s)
  加美野宏樹、中村康之、佐野仁哉、齋藤有理、二村学、吉田和弘、平岡伸介、金井弥栄、九嶋亮治、荒川博文
- Organizer
  平成25年度文科省科研費新学術領域研究『がん研究分野の特性等を踏まえた支援活動』がん若手研究者ワークショップ
- Place of Presentation
  茅野市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap controls mitochondrial quality by repairing or eliminating unhealthy mitochondria2013
- Author(s)
  加美野宏樹、中村康之、喜多村憲章、佐野仁哉、市ノ瀬志津子、荒川博文
- Organizer
  Cell Symposia 2013 Mitochondria
- Place of Presentation
  ポルトガル(リスボン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Critical role of Mieap in sperm motility through mitochondrial quality control (精子運動能におけるミトコンドリア品質管理機構を介したMieapの極めて重要な役割について)2013
- Author(s)
  齋藤有理、中村康之、加美野宏樹、佐野仁哉、村井竜也、吉田将紀、荒川博文
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap誘導性液胞様構造物の形成におけるUVRAGとの結合を介したMieapαの役割について2013
- Author(s)
  加美野宏樹
- Organizer
  第7回オートファジー研究会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control pathway in gastric tumor suppression (胃がんのがん抑制におけるMieap 制御性ミトコンドリア品質管理構機の役割について)2013
- Author(s)
  佐野仁哉、中村康之、加美野宏樹、村井竜也、齋藤有理、二村学、吉田和弘、荒川博文
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜市
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Potential role of the Mieap-regulated mitochondrial quality control pathway in gastric tumor suppression2013
- Author(s)
  佐野仁哉、中村康之、加美野宏樹、齋藤有理、二村学、吉田和弘、荒川博文
- Organizer
  International Symposium on Mitochondoria 2013
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in colorectal cancer2013
- Author(s)
  加美野宏樹
- Organizer
  第104回米国癌研究会議
- Place of Presentation
  Washington D.C., U.S.A.
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Frequent inactivation of the p53/Mieap/BNIP3 mitochondrial quality control pathway in gastric cancer2013
- Author(s)
  佐野仁哉、加美野宏樹、中村康之、、吉田将紀、村井竜也、齋藤有理、二村学、吉田和弘、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  アメリカ(ワシントン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria2013
- Author(s)
  加美野宏樹
- Organizer
  Cell Symposia [Mitochondria: from Signaling to Disease]
- Place of Presentation
  Lisbon, Portugal
- Data Source
  KAKENHI-PROJECT-25430125
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer2013
- Author(s)
  加美野宏樹、中村康之、佐野仁哉、村井竜也、齋藤有理、二村学、吉田和弘、平岡伸介、金井弥栄、九嶋亮治、荒川博文
- Organizer
  International Symposium on Mitochondoria 2013
- Place of Presentation
  東京都
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria2013
- Author(s)
  中村康之、加美野宏樹、喜多村憲章、宮本裕士、佐野仁哉、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2013
- Place of Presentation
  アメリカ(ワシントン)
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria.
- Author(s)
  Hiroki Kamino
- Organizer
  Cell Symposia “Mitochondria: from signaling to disease”
- Place of Presentation
  Lisbon (Portugal)
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Specific role of Mieap a in Mieap-induced vacuole generation through an interaction with UVRAG
- Author(s)
  中村康之、加美野宏樹、齋藤有理、喜多村憲章、佐野仁哉、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2014
- Place of Presentation
  アメリカ（サンディエゴ）
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] 膵がん及び乳がんで見られるMieapによるミトコンドリア品質管理機構の破綻とその意義について
- Author(s)
  加美野宏樹
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Mieap controls mitochondrial quality by repairing or eliminating unhealthy mitochondria
- Author(s)
  Hiroki Kamino
- Organizer
  The 6th International Symposium on Autophagy 2012
- Place of Presentation
  Okinawa
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] マウス消化管腫瘍の発生及び進展におけるMieap制御性ミトコンドリア品質管理機構の役割
- Author(s)
  中村康之、喜多村憲章、加美野宏樹、佐野仁哉、村井竜也、 Yuri Saito and Hirofumi Arakawa
- Organizer
  第73回日本癌学会学術総会
- Place of Presentation
  横浜市
- Year and Date
  2014-09-25 – 2014-09-27
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] p53-dependent and independent functions of Mieap
- Author(s)
  中村康之、加美野宏樹、齋藤有理、佐野仁哉、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2014
- Place of Presentation
  アメリカ（サンディエゴ）
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] 大腸がんで高頻度に生じるMieap制御性ミトコンドリア品質管理機構の不活性化
- Author(s)
  加美野宏樹
- Organizer
  第35回日本分子生物学会年会
- Place of Presentation
  福岡市
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] 大腸がんでみられるMieap制御性ミトコンドリア品質管理機構の破綻とその意義について
- Author(s)
  加美野宏樹
- Organizer
  第12回日本ミトコンドリア学会年会
- Place of Presentation
  つくば市
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in pancreatic and breast cancer
- Author(s)
  加美野宏樹、中村康之、佐野仁哉、村井竜也、齋藤有理、二村学、吉田和弘、平岡伸介、金井弥栄、九嶋亮治、片桐豊雅、荒川博文
- Organizer
  American Association for Cancer Research Annual Meeting 2014
- Place of Presentation
  アメリカ（サンディエゴ）
- Year and Date
  2014-04-05 – 2014-04-09
- Data Source
  KAKENHI-PROJECT-25430124
[Presentation] 大腸がんで高頻度に生じるMieapによるミトコンドリア品質管理機構の破綻について
- Author(s)
  加美野宏樹
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  札幌市
- Data Source
  KAKENHI-PROJECT-24240117
[Presentation] Frequent inactivation of the Mieap-regulated mitochondrial quality control in colorectal cancer.
- Author(s)
  Hiroki Kamino
- Organizer
  AACR Annual Meeting 2013.
- Place of Presentation
  Washington D.C.(USA)
- Data Source
  KAKENHI-PROJECT-24240117

1. ARAKAWA Hirofumi (70313088)

# of Collaborated Projects: 3 results

# of Collaborated Products: 32 results
2. NAKAMURA Yasuyuki (90569063)

# of Collaborated Projects: 3 results

# of Collaborated Products: 31 results
3. Urano Takeshi (70293701)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
4. 杉浦智子 (60647402)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YOSHIDA Masaki (20625686)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. KATO Hiroaki

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 尾林栄治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

KAMINO HIROKI 加美野 宏樹

KAMINO Hiroki 加美野 宏樹

Research Projects

Research Products

Co-Researchers

ショウガの持つIL-18活性化阻害の作用機序解明と医療応用に向けた基礎研究Principal Investigator

Principal Investigator

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マクロファージ活性化症候群の新しいマウスモデルの作製と治療応用に向けた研究

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Basic research on antibody therapy against inflammatory cytokine IL-18 for refractory inflammatory diseases

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Development of novel pancreatic cancer treatment using IL-18 inhibitory antibodyPrincipal Investigator

Principal Investigator

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Analysis of p53/Mieap pathway in primary human cancer tissuesPrincipal Investigator

Principal Investigator

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Research Institution

Potential role of the Mieap-regulated mitochondrial quality control in murine intestinal tumorigenesis

Principal Investigator

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Research Institution

Mieap, a p53-inducible protein, controls mitochondrial quality by repairing or eliminating unhealthy mitochondria

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Monoclonal Antibodies Against Mature Interleukin-18 Ameliorate Colitis and Repair Goblet Cell Function2024

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DOI

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[Journal Article] Generation of the novel anti-FXYD5 monoclonal antibody and its application to the diagnosis of pancreatic and lung cancer2023

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[Journal Article] Generation of antagonistic monoclonal antibodies against the neoepitope of active mouse interleukin (IL)-18 cleaved by inflammatory caspases2022

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[Journal Article] Kinetics of Anti-SARS-CoV-2 Antibody Response Following Two Doses of the BNT162b2 mRNA Vaccine: A Japanese Single-Center Primary Care Clinic Report Involving Volunteers and Patients with Autoimmune Disease2022

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[Journal Article] Screening of a Panel of Low Molecular Weight Compounds That Inhibit Synovial Fibroblast Invasion in Rheumatoid Arthritis2020

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[Journal Article] p53/Mieap-regulated mitochondrial quality control plays an important role as a tumor suppressor in gastric and esophageal cancers2020

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[Journal Article] Mieap-regulated mitochondrial quality control is frequently inactivated in human colorectal cancer.2016

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KAMINO HIROKI 加美野宏樹

KAMINO Hiroki 加美野宏樹