Kobayashi Tominari 小林富成

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KOBAYASHI Tominari 小林富成

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Researcher Number	00634164
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2016 – 2017: 自治医科大学, 医学部, 助教 2012 – 2014: 自治医科大学, 医学部, 助教
Review Section/Research Field	Principal Investigator Virology Except Principal Investigator Virology
Keywords	Principal Investigator リアルタイムRT-PCR法 / リバースジェネティクス法 / ウイルス複製 / E型肝炎ウイルス / PSAP / RNA複製 / HEV / PSAPモチーフ / 細胞培養 / レプリコン / cell-free蛋白質翻訳系 / 5'非翻訳領域 … More Except Principal Investigator … More E型肝炎ウイルス / 放出 / Tsg101 / エンベロープ / エクソソーム分泌経路 / 出芽 / 多胞体 / エクソソーム / ESCRT機構 / MVB経路 / エンドソーム輸送 / Vps4 / MVB 経路 / 粒子形成 / E 型肝炎ウイルス / MVB sorting / 放出機構 / PSAPモチーフ / ORF3蛋白質 / ゲノム変異 / 劇症肝炎 / 感染性cDNAクローン / 細胞レセプター候補分子 / 吸着 / 感受性細胞 / 感染性 cDNA クローン / 感染培養系 Less

Functional analysis of host factor participating in replication mechanism of the hepatitis E virus genome RNAPrincipal Investigator
- Principal Investigator
  
  Kobayashi Tominari
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on mechanism of hepatitis E virus egress utilizing membrane traffic
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the functional role of 5' untranslated region of the genome RNA in the replication of hepatitis E virusPrincipal Investigator
- Principal Investigator
  
  KOBAYASHI Tominari
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles
- Principal Investigator
  
  NAGASHIMA Shigeo
- Project Period (FY)
  2011 – 2012
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University
Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV
- Principal Investigator
  
  OKAMOTO Hiroaki
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  Jichi Medical University

All 2018 2017 2016 2014 2013 2012 Other

All Journal Article Presentation

[Journal Article] An analysis of two open reading frames (ORF3 and ORF4) of rat hepatitis E virus genome using its infectious cDNA clones with mutations in ORF3 or ORF42018
- Author(s)
  Tanggis、Kobayashi Tominari、Takahashi Masaharu、Jirintai Suljid、Nishizawa Tsutomu、Nagashima Shigeo、Nishiyama Takashi、Kunita Satoshi、Hayama Emiko、Tanaka Takeshi、Mulyanto、Okamoto Hiroaki
- Journal Title
  
  Virus Research
  
  Volume: 249 Pages: 16-30
- DOI
  10.1016/j.virusres.2018.02.014
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19144, KAKENHI-PROJECT-16K08817
[Journal Article] Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan2017
- Author(s)
  Primadharsini PP, Miyake M, Kunita S, Nishizawa T, Takahashi M, Nagashima S, Tanggis, Ohnishi H, Kobayashi T, Nishiyama T, Jirintai S, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 240 Pages: 147-153
- DOI
  10.1016/j.virusres.2017.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway2017
- Author(s)
  Nagashima Shigeo、Takahashi Masaharu、Kobayashi Tominari、Nishizawa Tsutomu、Nishiyama Takashi、Primadharsini Putu Prathiwi、Okamoto Hiroaki、Tanggis
- Journal Title
  
  Journal of Virology
  
  Volume: 91 Issue: 22
- DOI
  10.1128/jvi.00822-17
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system.2016
- Author(s)
  Kobayashi T, Takahashi M, Tanggis, Mulyanto, Jirintai S, Nagashima S, Nishizawa T, Okamoto H.
- Journal Title
  
  Journal of Virological Methods
  
  Volume: 233 Pages: 78-88
- DOI
  10.1016/j.jviromet.2016.03.004
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles.2016
- Author(s)
  Takahashi M, Kobayashi T, Tanggis, Jirintai S, Mulyanto, Nagashima S, Nishizawa T, Kunita S, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume: 161 Issue: 12 Pages: 3391-3404
- DOI
  10.1007/s00705-016-3047-9
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K19144
[Journal Article] Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.2016
- Author(s)
  Nagashima S, Kobayashi T, Tanaka T, Tanggis, Jirintai S, Takahashi M, Nishizawa T, Okamoto H.
- Journal Title
  
  Virus Research
  
  Volume: 223 Pages: 170-180
- DOI
  10.1016/j.virusres.2016.07.011
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08817, KAKENHI-PROJECT-16K19144
[Journal Article] Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient.2016
- Author(s)
  Nishizawa T, Hoshino T, Naganuma A, Kobayashi T, Nagashima S, Takahashi M, Takagi H, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume: 97 Issue: 10 Pages: 2643-2656
- DOI
  10.1099/jgv.0.000566
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K19144
[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 22014
- Author(s)
  Nagashima S, Takahashi M, Jirintai S, Tanggis, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Archives of Virology
  
  Volume: 159 Issue: 5 Pages: 979-991
- DOI
  10.1007/s00705-013-1912-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines2014
- Author(s)
  Jirintai S, Tanggis, Mulyanto, Suparyatmo JB, Takahashi M, Kobayashi T, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Research
  
  Volume: 185 Pages: 92-102
- DOI
  10.1016/j.virusres.2014.03.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Hepatitis E virus egress depends on the exosomal pathway, with secretory exosomes derived from multivesicular bodies2014
- Author(s)
  Nagashima S, Jirintai S, Takahashi M, Kobayashi T, Tanggis, Nishizawa T, Kouki T, Yashiro T, Okamoto H
- Journal Title
  
  Journal of General Virology
  
  Volume: 95 Issue: 10 Pages: 2166-2175
- DOI
  10.1099/vir.0.066910-0
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-25860343, KAKENHI-PROJECT-25860344
[Journal Article] Characterization of sporadic acute hepatitis E and comparison of hepatitis E virus genomes in acute hepatitis patients and pig liver sold as food in Mie, Japan2014
- Author(s)
  Okano H, Takahashi M, Isono Y, Tanaka H, Nakano T, Oya Y, Sugimoto K, Ito K, Ohmori S, Maegawa T, Kobayashi M, Nagashima S, Nishizawa T, Okamoto H
- Journal Title
  
  Hepatology Research
  
  Volume: 印刷中 Issue: 10
- DOI
  10.1111/hepr.12216
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25860343
[Journal Article] New findings regarding the epidemic history and population dynamics of Japan-indigenous genotype 3 hepatitis E virus inferred by molecular evolution2012
- Author(s)
  Nakano T, Takahashi K, Pybus OG, Hashimoto N, Kato H, Okano H, Kobayashi M, Fujita N, Shiraki K, Takei Y, Ayada M, Arai M, Okamoto H, Mishiro S.
- Journal Title
  
  Liver Int
  
  Volume: 32(4) Pages: 675-88
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  D, Mulyanto, Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H
- Journal Title
  
  Virus Res
  
  Volume: 170(1-2) Pages: 126-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular epidemiology and genetic history of European-type genotype 3 hepatitis E virus indigenized in the central region of Japan2012
- Author(s)
  Nakano T, Okano H, Kobayashi M, Ito K, Ohmori S, Nomura T, Kato H, Ayada M, Nakano Y, Akachi S, Sugimoto K, Fujita N, Shiraki K, Takei Y, Takahashi M, Okamoto H
- Journal Title
  
  Infect Genet Evol
  
  Volume: 12(7) Pages: 1524-34
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090
[Journal Article] Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells2012
- Author(s)
  Jirintai S
- Journal Title
  
  Virus Research
  
  Volume: 170 Issue: 1-2 Pages: 126-137
- DOI
  10.1016/j.virusres.2012.09.015
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390090, KAKENHI-PROJECT-22590419, KAKENHI-PROJECT-23790508
[Presentation] 感染培養系を用いたE型肝炎治療薬の検討2017
- Author(s)
  小林富成、西山尚志、長嶋茂雄、西澤勉、高橋雅春、唐吉思、Putu Prathiwi Primadharsini、岡本宏明
- Organizer
  第65回　日本ウイルス学会学術集会
- Data Source
  KAKENHI-PROJECT-16K19144
[Presentation] Development of a plasmid-based reverse genetics system for hepatitis E virus2016
- Author(s)
  小林富成、長嶋茂雄、西澤勉、唐吉思、高橋雅春、岡本宏明
- Organizer
  第64回日本ウイルス学会学術集会
- Place of Presentation
  北海道　札幌市　札幌コンベンションセンター
- Year and Date
  2016-11-23
- Data Source
  KAKENHI-PROJECT-16K19144
[Presentation] E型肝炎ウイルスの5’非翻訳領域におけるステム構造変異の増殖効率への影響2014
- Author(s)
  小林富成、高橋雅春、長嶋茂雄、西澤勉、吉林台、岡本宏明
- Organizer
  第62回　日本ウイルス学会学術集会
- Place of Presentation
  パシフィコ横浜　会議センター
- Year and Date
  2014-11-10
- Data Source
  KAKENHI-PROJECT-25860344
[Presentation] 細胞内膜輸送系を利用したE型肝炎ウイルスの放出機構の解析2013
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、小林富成、西澤勉、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] 培養細胞から放出された E 型肝炎ウイルスの粒子表面に存在する膜成分の抗原性の解析2012
- Author(s)
  長嶋茂雄、高橋雅春、吉林台、西澤勉、小林富成、岡本宏明
- Organizer
  第60回日本ウイルス学会学術集会
- Place of Presentation
  大阪
- Year and Date
  2012-11-14
- Data Source
  KAKENHI-PROJECT-23790508
[Presentation] E型肝炎ウイルスの細胞侵入機構の解析
- Author(s)
  長嶋茂雄、吉林台、小林富成、唐吉思、高橋雅春、西澤勉、岡本宏明
- Organizer
  第62回日本ウイルス学会学術集会
- Place of Presentation
  横浜（パシフィコ横浜）
- Year and Date
  2014-11-10 – 2014-11-12
- Data Source
  KAKENHI-PROJECT-25860343
[Presentation] E型肝炎ウイルスの複製機構に関与する5’非翻訳領域の構造と機能に関する研究
- Author(s)
  小林富成、高橋雅春、長嶋茂雄、西澤勉、吉林台、岡本宏明
- Organizer
  第61回日本ウイルス学会学術集会
- Place of Presentation
  神戸国際会議場
- Data Source
  KAKENHI-PROJECT-25860344

1. OKAMOTO Hiroaki (30177092)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
2. NAGASHIMA Shigeo (60433116)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. TAKAHASHI Masaharu (70326841)

# of Collaborated Projects: 3 results

# of Collaborated Products: 10 results
4. NISHIZAWA Tsutomu (30306112)

# of Collaborated Projects: 2 results

# of Collaborated Products: 7 results
5. YASUDA Jiro (10282518)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. YASHIRO Takashi (80119859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. KOUKI Tom (70350436)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 田中利典 (30146154)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kobayashi Tominari 小林 富成

KOBAYASHI Tominari 小林 富成

Research Projects

Research Products

Co-Researchers

Functional analysis of host factor participating in replication mechanism of the hepatitis E virus genome RNAPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on mechanism of hepatitis E virus egress utilizing membrane traffic

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the functional role of 5' untranslated region of the genome RNA in the replication of hepatitis E virusPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the identification and acquisition mechanism ofcell-derived membrane on the surface of hepatitis E virus particles

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Research on release mechanism, genome mutations and cellular receptor of hepatitis E virus (HEV) using cell culture systems for HEV

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] An analysis of two open reading frames (ORF3 and ORF4) of rat hepatitis E virus genome using its infectious cDNA clones with mutations in ORF3 or ORF42018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Full-length genome of a novel genotype 3 hepatitis E virus strain obtained from domestic pigs in Japan2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization of the Quasi-Enveloped Hepatitis E Virus Particles Released by the Cellular Exosomal Pathway2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Characterization and epitope mapping of monoclonal antibodies raised against rat hepatitis E virus capsid protein: An evaluation of their neutralizing activity in a cell culture system.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Production of monoclonal antibodies against the ORF3 protein of rat hepatitis E virus (HEV) and demonstration of the incorporation of the ORF3 protein into enveloped rat HEV particles.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of adaptive mutations selected during the consecutive passages of hepatitis E virus produced from an infectious cDNA clone.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patient.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] The membrane on the surface of hepatitis E virus particles is derived from the intracellular membrane and contains trans-Golgi network protein 22014

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rat hepatitis E virus derived from wild rats (Rattus rattus) propagates efficiently in human hepatoma cell lines2014

Author(s)

Journal Title

DOI

Data Source

Kobayashi Tominari 小林富成

KOBAYASHI Tominari 小林富成