Komori Hisakazu 小森久和

… Alternative Names

KOMORI Hisakazu 小森久和

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Researcher Number	00634180
Other IDs
Affiliation (based on the past Project Information) *help	2015 – 2022: 金沢大学, 薬学系, 助教 2012 – 2013: 金沢大学, 薬学系, 助教
Review Section/Research Field	Principal Investigator Basic Section 47060:Clinical pharmacy-related / Medical pharmacy Except Principal Investigator Applied pharmacology
Keywords	Principal Investigator 翻訳後修飾 / 細胞内局在 / ABCG2 / 尿酸 / ユビキチン / SNP / Transporter / Hyperuricemia / Ubiquitination / 内在化 … More / 血管障害 / ABCG2/BCRP / 酸化ストレス / 高尿酸血症 / 輸送体 / 糖尿病 / 解糖系 / インスリン / 尿酸輸送体 … More Except Principal Investigator 肺線維症 / 薬理学 / 薬学 / 酵素 / 輸送体 / 発現 / プロスタグランジン輸送体 / 薬物代謝酵素・トランスポーター / マクロファージ / OATP2A1/SLCO2A1 / 炎症 / プロスタグランジン / 線維化 / 肺 / トランスポーター Less

ABCG2遺伝性疾患の翻訳後修飾制御に基づく治療戦略の分子基盤樹立Principal Investigator
- Principal Investigator
  
  小森久和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Investigation of abnormal ABCG2 localization regulated by post-transcriptional modificationPrincipal Investigator
- Principal Investigator
  
  Komori Hisakazu
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 47060:Clinical pharmacy-related
- Research Institution
  Kanazawa University
Mechanism of vascular injury due to interaction between hyperuricemia and metabolic diseasesPrincipal Investigator
- Principal Investigator
  
  Komori Hisakazu
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University
Role of prostaglandin transporter in pulmonary fibrosis and its therapeutic significance
- Principal Investigator
  
  Nakanishi Takeo
- Project Period (FY)
  2015 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Applied pharmacology
- Research Institution
  Kanazawa University
Exploration of association mechanism between hyperuricemia and insulin resistancePrincipal Investigator
- Principal Investigator
  
  KOMORI Hisakazu
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Medical pharmacy
- Research Institution
  Kanazawa University

All 2021 2019 2018 2015 2014 2013 2012

All Journal Article Presentation

[Journal Article] Uptake pathway of apple-derived nanoparticle by intestinal cells to deliver its cargo.2021
- Author(s)
  Arai M, Komori H, Fujita D, Tamai I
- Journal Title
  
  Pharmaceutical Research
  
  Volume: 38 Issue: 3 Pages: 523-530
- DOI
  10.1007/s11095-021-03018-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21474, KAKENHI-PROJECT-19K16408
[Journal Article] Experimental evidence for resecretion of PGE2 across rat alveolar epithelium by OATP2A1/SLCO2A1-mediated transcellular transport2019
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Journal Title
  
  J Pharmacol Exp Ther
  
  Volume: 368 Issue: 2 Pages: 317-325
- DOI
  10.1124/jpet.118.249789
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia2019
- Author(s)
  Nishizawa Kei、Yoda Noriaki、Morokado Fumi、Komori Hisakazu、Nakanishi Takeo、Tamai Ikumi
- Journal Title
  
  PLOS ONE
  
  Volume: 14 Issue: 4 Pages: 0214862-0214862
- DOI
  10.1371/journal.pone.0214862
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K15500, KAKENHI-PROJECT-16H05111
[Journal Article] Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.2018
- Author(s)
  Hisakazu Komori, Kazuyuki Yamada, Ikumi Tamai
- Journal Title
  
  Biochim Biophys Acta
  
  Volume: 1860(5) Issue: 5 Pages: 973-980
- DOI
  10.1016/j.bbamem.2018.01.006
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K15500, KAKENHI-PROJECT-16H05111
[Journal Article] Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis2015
- Author(s)
  Nakanishi T, Hasegawa Y, Mimura R, Wakayama T, Uetoko Y, Komori H, Akanuma S, Hosoya K, Tamai I.
- Journal Title
  
  PLoS One
  
  Volume: 10(4) Issue: 4 Pages: e0123895-e0123895
- DOI
  10.1371/journal.pone.0123895
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04755
[Journal Article] 薬物トランスポーターと相互作用2014
- Author(s)
  小森久和、玉井郁巳
- Journal Title
  
  日本薬理学雑誌
  
  Volume: 143 Pages: 243-248
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890073
[Journal Article] Transporter-mediated drug interaction2014
- Author(s)
  Hisakazu Komori and Ikumi Tamai
- Journal Title
  
  Folia Pharmacologica Japonica
  
  Volume: 143 Issue: 5 Pages: 243-248
- DOI
  10.1254/fpj.143.243
- NAID
  130004827696
- ISSN
  0015-5691, 1347-8397
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] ABCG2-Q141K変異体の翻訳後修飾による発現低下メカニズムの解明2021
- Author(s)
  小森久和、村山枝美果、諸角芙美、玉井郁巳
- Organizer
  第42回生体膜と薬物の相互作用シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16408
[Presentation] ABCG2 Q141K変異体の発現局在に及ぼす翻訳後修飾の影響2019
- Author(s)
  小森久和、村山枝美果、八杉優護、玉井郁巳
- Organizer
  第14回トランスポーター研究会年会
- Data Source
  KAKENHI-PROJECT-19K16408
[Presentation] Post-transcriptional regulation of prostaglandin transporter (OATP2A1/SLCO2A1) during the epithelial-mesenchymal transition2018
- Author(s)
  Komori H, Nakanishi T, Takashima H, Honda R, Tamai I
- Organizer
  第33回日本薬物動態学会/第22回MDOシンポジウム合同国際学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Pathophysiological relevance prostaglandin transporter OATP2A1/SLCO2A1 expressed in alveolar epithelial cells2018
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Organizer
  International Conference on the Bioscience of Lipids
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] Functional characterization of prostaglandin transporter OATP2A1/SLCO2A1 in alveolar epithelial cells2018
- Author(s)
  Nakanishi T, Takashima H, Uetoko Y, Komori H, Tamai I
- Organizer
  The 2nd Workshop for Korea-Japan Young Scientists on Pharmaceutics
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04755
[Presentation] 血管内皮細胞における尿酸輸送体を介した酸化ストレス調節2013
- Author(s)
  Komori. H
- Organizer
  第46回　日本痛風・核酸代謝学会総会
- Place of Presentation
  京王プラザホテル（東京）
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] 血管内皮細胞障害への尿酸輸送体の関与2013
- Author(s)
  Komori. H
- Organizer
  第23回　北陸尿酸談話会
- Place of Presentation
  KKRホテル金沢（石川）
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] A possible enhanced effect of coffee constituents on intestinal urate excretion via BCRP2013
- Author(s)
  生川幸司,小森久和,中西猛夫,玉井郁巳
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] Involvement of renal reabsorptive transporters in insulin-dependent increase of serum uric acid2013
- Author(s)
  小森久和,大箭考平,中西猛夫,玉井郁巳
- Organizer
  日本薬物動態学会第28年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2013-10-09
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] 血管内皮細胞障害への尿酸輸送体の関与2013
- Author(s)
  小森久和,安西尚彦,中西猛夫,玉井郁巳
- Organizer
  第23回北陸尿酸談話会
- Place of Presentation
  KKRホテル金沢
- Year and Date
  2013-03-02
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] 血管内皮細胞における尿酸輸送体を介した酸化ストレス調節2013
- Author(s)
  小森久和,安西尚彦,中西猛夫,玉井郁巳
- Organizer
  第46回日本痛風・核酸代謝学会総会
- Place of Presentation
  京王プラザホテル
- Year and Date
  2013-02-14
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] A possible enhanced effect of coffee constituents on intestinal urate excretion via BCRP2013
- Author(s)
  生川幸司、小森久和、中西猛夫、玉井郁巳
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] Involvement of renal reabsorptive transporters in insulin-dependent increase of serum uric acid2013
- Author(s)
  小森久和、大箭考平、中西猛夫、玉井郁巳
- Organizer
  日本薬物動態学会第28回年会
- Place of Presentation
  タワーホール船堀（東京）
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] In vitro evidence for functional interplay of SMCT1 and URAT1 for renal reabsorption of urate2012
- Author(s)
  盧楊,中西猛夫,小森久和,玉井郁巳
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] α1-acid glycoprotein exerts protective effect against hemolysis-induced oxidative stress via the enhancement of CD163 expression2012
- Author(s)
  小森久和,渡邊博志,首藤剛,小玉あずさ,甲斐博文,小田切優樹,玉井郁巳,丸山徹
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] OATP transporters is involved in intestinal absorption of urate2012
- Author(s)
  生川幸司,御勢智香,小森久和,中西猛夫,玉井郁巳
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24890073
[Presentation] Effect of drugs on renal urate reabsorption : evaluation by URAT1/URATv1 co-expressing cells2012
- Author(s)
  大箭考平,中西猛夫,小森久和,玉井郁巳
- Organizer
  日本薬物動態学会第27年会
- Place of Presentation
  タワーホール船堀
- Year and Date
  2012-11-20
- Data Source
  KAKENHI-PROJECT-24890073

1. TAMAI Ikumi (20155237)

# of Collaborated Projects: 2 results

# of Collaborated Products: 14 results
2. Nakanishi Takeo (30541742)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
3. Wakayama Tomohiko

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. Deguchi Yoshiharu

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. Hinoi Eiichi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Komori Hisakazu 小森 久和

KOMORI Hisakazu 小森 久和

Research Projects

Research Products

Co-Researchers

ABCG2遺伝性疾患の翻訳後修飾制御に基づく治療戦略の分子基盤樹立Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of abnormal ABCG2 localization regulated by post-transcriptional modificationPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanism of vascular injury due to interaction between hyperuricemia and metabolic diseasesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of prostaglandin transporter in pulmonary fibrosis and its therapeutic significance

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploration of association mechanism between hyperuricemia and insulin resistancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Uptake pathway of apple-derived nanoparticle by intestinal cells to deliver its cargo.2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Experimental evidence for resecretion of PGE2 across rat alveolar epithelium by OATP2A1/SLCO2A1-mediated transcellular transport2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Changes of drug pharmacokinetics mediated by downregulation of kidney organic cation transporters Mate1 and Oct2 in a rat model of hyperuricemia2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Hyperuricemia enhances intracellular urate accumulation via down-regulation of cell-surface BCRP/ABCG2 expression in vascular endothelial cells.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 薬物トランスポーターと相互作用2014

Author(s)

Journal Title

Data Source

[Journal Article] Transporter-mediated drug interaction2014

Author(s)

Journal Title

DOI

NAID

ISSN

Language

Data Source

[Presentation] ABCG2-Q141K変異体の翻訳後修飾による発現低下メカニズムの解明2021

Author(s)

Organizer

Data Source

[Presentation] ABCG2 Q141K変異体の発現局在に及ぼす翻訳後修飾の影響2019

Author(s)

Organizer

Data Source

Komori Hisakazu 小森久和

KOMORI Hisakazu 小森久和