YOKOYAMA KAZUAKI 横山和明

Researcher Number	00647498
Affiliation (Current)	2025: 東京大学, 医科学研究所, 准教授
Affiliation (based on the past Project Information) *help	2022 – 2024: 東京大学, 医科学研究所, 准教授 2016 – 2021: 東京大学, 医科学研究所, 助教
Review Section/Research Field	Principal Investigator Basic Section 49030:Experimental pathology-related / Tumor therapeutics Except Principal Investigator Basic Section 54010:Hematology and medical oncology-related / Basic Section 62010:Life, health and medical informatics-related
Keywords	Principal Investigator オミクス解析 / マルチオミクス / 全ゲノム / エンハンサー / 全ゲノム解析 / 有毛細胞白血病 / シングルセルRNA解析 / １細胞RNAシーケンス / シングルセル解析 / 間葉系幹細胞 … More / 1細胞RNAシーケンス解析 / 急性移植片対宿主病 / 造血幹細胞移植 / mTORC1 / 進行期慢性骨髄性白血病 / 薬剤耐性 / TKI / CML / Akt / PI3K / mTOR / チロシンキナーゼ阻害剤 / 慢性骨髄性白血病 … More Except Principal Investigator 薬剤耐性 / チロシンキナーゼ阻害薬 / 慢性骨髄性白血病 / 病態予測モデル / スパースモデリング / 個別変異データ / 病態遷移モデル / 変異検出 / 微小残存病変 / 有用情報抽出 / 異種情報統合 / 異種多次元データ / 情報統合 / 病態予測 Less

TKI抵抗性CMLに対するエキソーム解析とFRET解析の統合による個別化治療の可能性
- Principal Investigator
  
  高橋直人
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 54010:Hematology and medical oncology-related
- Research Institution
  Akita University
whole genome and multiomics analysis of hairy cell leukemia japansese variantPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA KAZUAKI
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Harnessing the single-cell biology and biomarker involving in the therapeutic response of patients with severe acute graft-versus-host disease undergoing mesenchymal stem cell transfusionPrincipal Investigator
- Principal Investigator
  
  Yokoyama Kazuaki
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 49030:Experimental pathology-related
- Research Institution
  The University of Tokyo
Study on statistical methods to integrate high-dimensional and heterogenous biomedical data for predicting and controlling disease progression
- Principal Investigator
  
  Yamaguchi Rui
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Aichi Cancer Center Research Institute
  The University of Tokyo
Identification of deregulated mTORC1 signaling in advanced chronic myelogenous leukemiaPrincipal Investigator
- Principal Investigator
  
  YOKOYAMA KAZUAKI
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Tumor therapeutics
- Research Institution
  The University of Tokyo

All 2023 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book

[Book] 令和３年度厚生労働省委託事業がんの全ゲノム解析に関する人材育成推進事業テキスト4章2021
- Author(s)
  横山和明清水英悟
- Publisher
  厚生労働省
- Data Source
  KAKENHI-PROJECT-21H02711
[Book] 人工知能の臨床応用-血液疾患-,日本病院薬剤師会雑誌2018
- Author(s)
  小川弥穂、横山和明、東條有伸.
- Total Pages
  5
- Publisher
  日本病院薬剤師会
- Data Source
  KAKENHI-PROJECT-16K21012
[Book] 人工知能ワトソンを用いた疾患診断. 感染炎症免疫2017
- Author(s)
  中村聡介、横山和明
- Total Pages
  3
- Publisher
  医薬の門社
- Data Source
  KAKENHI-PROJECT-16K21012
[Book] 血液がんの臨床シークエンスにおける人工知能Watsonの活用. 医学のあゆみ2017
- Author(s)
  横山和明、東條有伸
- Total Pages
  4
- Publisher
  医歯薬出版株式会社
- Data Source
  KAKENHI-PROJECT-16K21012
[Book] 人口知能を用いた臨床シークエンス. 腫瘍内科2017
- Author(s)
  横山和明、東條有伸
- Total Pages
  5
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16K21012
[Book] 腫瘍内科2017
- Author(s)
  横山和明　東條有伸
- Total Pages
  6
- Publisher
  科学評論社
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] Explainable AI for Estimating Pathogenicity of Genetic Variants Using Large-Scale Knowledge Graphs.2023
- Author(s)
  Abe S, Tago S, Yokoyama K, Ogawa M, Takei T, Imoto S, Fuji M.
- Journal Title
  
  Cancers (Basel)
  
  Volume: 15 Issue: 4 Pages: 1118-1118
- DOI
  10.3390/cancers15041118
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02711
[Journal Article] MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.2022
- Author(s)
  Hayashi Y, Inoue D, et al.
- Journal Title
  
  Cell Reports
  
  Volume: VOLUME 39, ISSUE 6 Issue: 6 Pages: 110805-110805
- DOI
  10.1016/j.celrep.2022.110805
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21622, KAKENHI-PROJECT-22K19539, KAKENHI-PROJECT-21K16258, KAKENHI-PROJECT-20H00537, KAKENHI-PROJECT-20H03711, KAKENHI-PROJECT-21H02711, KAKENHI-PROJECT-20J01911, KAKENHI-PROJECT-19K10024, KAKENHI-PROJECT-18KK0449, KAKENHI-PROJECT-20H03717, KAKENHI-PROJECT-21H02954
[Journal Article] Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses.2022
- Author(s)
  Sahara N, Yokoyama K, Matsunaga T, Kitahara S, Fujii T, Kobayashi S, Yusa N, Shimizu E, Imoto S, Tojo A, Ohno N.
- Journal Title
  
  Leuk Res Rep.
  
  Volume: 18 Pages: 100348-100348
- DOI
  10.1016/j.lrr.2022.100348
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H02711
[Journal Article] Repeated Lineage Switches in an Elderly Case of Refractory B-Cell Acute Lymphoblastic Leukemia With MLL Gene Amplification: A Case Report and Literature Review2022
- Author(s)
  Takeda Reina、Yokoyama Kazuaki、Fukuyama Tomofusa、Kawamata Toyotaka、Ito Mika、Yusa Nozomi、Kasajima Rika、Shimizu Eigo、Ohno Nobuhiro、Uchimaru Kaoru、Yamaguchi Rui、Imoto Seiya、Miyano Satoru、Tojo Arinobu
- Journal Title
  
  Frontiers in Oncology
  
  Volume: 12
- DOI
  10.3389/fonc.2022.799982
- Data Source
  KAKENHI-PROJECT-21H02711
[Journal Article] 急性骨髄性白血病や骨髄異形成症候群において同種移植後の循環腫瘍DNA残存は再発を予測するバイオマーカーである2021
- Author(s)
  横山和明
- Journal Title
  
  臨床血液
  
  Volume: in press
- NAID
  130008063721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16605
[Journal Article] 急性骨髄性白血病や骨髄異形成症候群において同種移植後の循環腫瘍DNA残存は再発を予測するバイオマーカーである2021
- Author(s)
  横山和明
- Journal Title
  
  臨床血液
  
  Volume: -
- NAID
  130008063721
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03329
[Journal Article] Role of Circulating Tumor DNA in Hematological Malignancy2021
- Author(s)
  Ogawa Miho、Yokoyama Kazuaki、Imoto Seiya、Tojo Arinobu
- Journal Title
  
  Cancers
  
  Volume: 13 Issue: 9 Pages: 2078-2078
- DOI
  10.3390/cancers13092078
- Data Source
  KAKENHI-PROJECT-21H02711
[Journal Article] Comprehensive molecular analysis of genomic profiles and PD-L1 expression in lung adenocarcinoma with a high-grade fetal adenocarcinoma component2021
- Author(s)
  Masaki Suzuki, Rika Kasajima, Tomoyuki Yokose, Hiroyuki Ito, Eigo Shimizu, Seira Hatakeyama, Kazuaki Yokoyama, Rui Yamaguchi, Yoichi Furukawa, Satoru Miyano, Seiya Imoto, Emi Yoshioka, Kota Washimi, Yoichiro Okubo, Kae Kawachi, Shinya Sato, Yohei Miyagi
- Journal Title
  
  Translational Lung Cancer Research
  
  Volume: 10 Issue: 3 Pages: 1292-1304
- DOI
  10.21037/tlcr-20-1158
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09422, KAKENHI-PROJECT-18K15111, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-21H02711
[Journal Article] Successful clinical sequencing by molecular tumor board in an elderly patient with refractory Sezary syndrome2020
- Author(s)
  Hijikata K, Yokoyama K (co-1st and co-corresponding author), Yokoyama N, Matsubara Y, Shimizu E, Nakashima M, Yamagishi M, Ota Y, Lim L, Yamaguchi R, Ito M, Tanaka Y, Denda T, Tani K, Yotsuyanagi H, Imoto S, Miyano S, Uchimaru K, Tojo A.
- Journal Title
  
  JCO Precis Oncol
  
  Volume: 4 Issue: 4 Pages: 534-560
- DOI
  10.1200/po.19.00254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-18H03329, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580
[Journal Article] Clinical features and outcomes of adult Langerhans cell histiocytosis: a single-center experience2020
- Author(s)
  Kobayashi Masayuki、Ando Shohei、Kawamata Toyotaka、Makiyama Junya、Yokoyama Kazuaki、Imai Yoichi、Tojo Arinobu
- Journal Title
  
  International Journal of Hematology
  
  Volume: 112 Issue: 2 Pages: 185-192
- DOI
  10.1007/s12185-020-02892-z
- Data Source
  KAKENHI-PROJECT-19K16605
[Journal Article] The EGFL7-ITGB3-KLF2 axis enhances survival of multiple myeloma in preclinical models.2020
- Author(s)
  Salama Y, Andries H, Yokoyama K, Takahashi S Hattori K and Heissig B,.
- Journal Title
  
  Blood Adv
  
  Volume: in press Issue: 6 Pages: 1021-1037
- DOI
  10.1182/bloodadvances.2019001002
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K08657, KAKENHI-PROJECT-19K08858, KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-17K09941, KAKENHI-PROJECT-19K08857
[Journal Article] 血液がんのプレシジョン・メディスンにおけるAI活用の試み2020
- Author(s)
  横山和明
- Journal Title
  
  臨床血液
  
  Volume: 61 Pages: 1-10
- NAID
  130007852311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K16605
[Journal Article] Immunophenotypic analysis of cerebrospinal fluid reveals concurrent development of ATL in the CNS of a HAM/TSP patient.2020
- Author(s)
  Takeda R, Ishigaki T, Ohno N, Yokoyama K, Kawamata T, Fukuyama T, Araya N, Yamano Y, Uchimaru K, Tojo A.
- Journal Title
  
  Int J Hematol
  
  Volume: 111(6) Issue: 6 Pages: 891-896
- DOI
  10.1007/s12185-019-02815-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08004, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-19K16605
[Journal Article] Artificial intelligence-guided precision medicine in hematological disorders2020
- Author(s)
  横山和明
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 61 Issue: 5 Pages: 554-563
- DOI
  10.11406/rinketsu.61.554
- NAID
  130007852311
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03329, KAKENHI-PROJECT-19K16605
[Journal Article] High Prevalence of Left Ventricular Non-Compaction and Its Effect on Chemotherapy-Related Cardiac Dysfunction in Patients With Hematological Diseases2020
- Author(s)
  Hirano M, Kimura K, Ishigaki T, Nojima M, Daimon M, Morita H, Takenaka K, Xu B, Sawada N, Hirokawa M, Komuro I, Morisaki T, Yotsuyanagi H, Kawamata T, Yokoyama K, Konuma T, Kato S, Yasui H, Nagamura-Inoue T, Uchimaru K, Takahashi S, Imai Y, Tojo A.
- Journal Title
  
  Circ J
  
  Volume: 84 Issue: 11 Pages: 1957-1964
- DOI
  10.1253/circj.CJ-20-0344
- NAID
  130007928999
- ISSN
  1346-9843, 1347-4820
- Year and Date
  2020-10-23
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K08748, KAKENHI-PROJECT-17K07092, KAKENHI-PROJECT-19K16605
[Journal Article] Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS.2019
- Author(s)
  Nakamura S, Yokoyama K (co-1st and co-corresponding author), Shimizu E, Yusa N, Kondoh K, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Inoue-Nagamura T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Blood
  
  Volume: In Press
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review2019
- Author(s)
  Takeda R, Yokoyama K (corresponding author), Kobayashi S, Kawamata T, S Nakamura, Tomofusa F, Ito M, Yusa N, Shimizu E, Ohno N, Yamaguchi R, Imoto S, Miyano S, Uchimaru K, and Tojo A.
- Journal Title
  
  Case Rep Hematol
  
  Volume: epub Pages: 4532434-4532434
- DOI
  10.1155/2019/4532434
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-18H03329
[Journal Article] The first case of elderly TCF3-HLF-positive B-cell acute lymphoblastic leukemia.2019
- Author(s)
  Takeda R, Yokoyama K (corresponding author), Ogawa M, Kawamata T, Tomofusa F, Kondoh K, Tomomi T, Nakamura S, Ito M, Yusa N, Shimizu E, Ohno N, Uchimaru K, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Leuk lymphoma.
  
  Volume: 60 Issue: 11 Pages: 2821-2824
- DOI
  10.1080/10428194.2019.1602267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS.2019
- Author(s)
  Nakamura S, Yokoyama K (co-1st and co-corresponding author), Shimizu E, Yusa N, Kondoh K, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Inoue-Nagamura T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Blood
  
  Volume: 133 Issue: 25 Pages: 2682-2695
- DOI
  10.1182/blood-2018-10-880690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Myeloablative single-unit cord blood transplantation overcomes the negative prognostic impact of FLT3-ITD in adult acute myeloid leukemia2019
- Author(s)
  Konuma Takaaki、Kato Seiko、Oiwa-Monna Maki、Mizusawa Mai、Isobe Masamichi、Yokoyama Kazuaki、Takahashi Satoshi、Tojo Arinobu
- Journal Title
  
  Leukemia & Lymphoma
  
  Volume: - Issue: 9 Pages: 2320-2323
- DOI
  10.1080/10428194.2019.1579325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03329
[Journal Article] サラセミア形質2例．2018
- Author(s)
  神保光児、小沼貴晶、横山和明、東條有伸
- Journal Title
  
  臨床血液
  
  Volume: In press
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] Phenotype-Based Gene Analysis Allowed Successful Diagnosis of X-Linked Neutropenia Associated with a Novel Wasp Mutation.2018
- Author(s)
  Kobayashi M, Yokoyama K, Shimizu E, Yusa N, Ito M, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Ann Hematol
  
  Volume: 97 Issue: 2 Pages: 367-369
- DOI
  10.1007/s00277-017-3134-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16J02129, KAKENHI-PROJECT-16H00660
[Journal Article] Azacitidine effectively reduces TP53-mutant leukemic cell burden in secondary acute myeloid leukemia after cord blood transplantation.2018
- Author(s)
  Takei T, Yokoyama K, Shimizu E, Konuma T, Takahashi S, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Leukemia and Lymphoma.
  
  Volume: In press
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] "Role of exosomes as a proinflammatory mediator in the development of EBV-associated lymphoma"2018
- Author(s)
  Higuchi H, Yamakawa N, Imadome K, Yahata T, Kotaki R, Ogata J, Kakizaki M, Fujita K, Jun Lu, Yokoyama K, Okuyama K, Sato A, Takamatsu M,Kurosaki N, Mohamad AS, Azhim A, Horie R, Watanabe T, Kitamura T, Ando K, Kashiwagi T, Matsui T, Okamoto A, Handa H, Kuroda M,Nakamura N, and Kotani A.
- Journal Title
  
  Blood
  
  Volume: In press
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation2018
- Author(s)
  Yoichi Imai, Mitsuhito Hirano, Koji Jimbo, Miho Ogawa, Kiyosumi Ochi, Junya Makiyama, Toyotaka Kawamata, Kazuaki Yokoyama, Takashi Tanaka, Yoshihiro Inamoto, Takahiro Fukuda, Yoshihisa Yamano, Kaoru Uchimaru, and Arinobu Tojo
- Journal Title
  
  Bone marrow transplantation
  
  Volume: In press
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] Circulating tumor DNA dynamically predicts response and/or relapse in patients with hematological malignancies2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Miyano S, Tojo A
- Journal Title
  
  Int J Hematol
  
  Volume: 108(4) Issue: 4 Pages: 402-410
- DOI
  10.1007/s12185-018-2487-2
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Cell lineage-oriented sequencing unveils the ontogeny of acute myeloid leukemia with myelodysplasia-related changes.2018
- Author(s)
  Yokoyama K, Shimizu E, Yokoyama N, Nakamura S, Kasajima R, Ogawa M, Takei T, Ito M, Kobayashi A, Yamaguchi R, Imoto S, Miyano S, Tojo A.
- Journal Title
  
  Blood Adv.
  
  Volume: 2 Pages: 2513-2421
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21012
[Journal Article] Different Clonal Dynamics of Chronic Myeloid Leukaemia between Bone Marrow and the Central Nervous System.2017
- Author(s)
  Ogawa M, Yokoyama K, Hirano M, Jimbo K, Ochi K, Kawamata T, Ohno N, Shimizu E, Yokoyama N, Yamaguchi R, Imoto S, Uchimaru K, Takahashi N, Miyano S, Imai Y, and Tojo A.
- Journal Title
  
  Br J Haematol
  
  Volume: - Issue: 5 Pages: 842-845
- DOI
  10.1111/bjh.15065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21012, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-15H05912
[Journal Article] Autologous peripheral blood stem cell transplantation for double-refractory myeloma with <i>K-RAS</i> and <i>N-RAS</i> mutations2017
- Author(s)
  神保光児、横山和明、小川弥穂、平野光人、越智清純、小林真之、遊佐　希、清水英悟、川俣豊隆、大野伸広、山口　類、井元清哉、古川洋一、宮野　悟、今井陽一、東條有伸.
- Journal Title
  
  Rinsho Ketsueki
  
  Volume: 58 Issue: 12 Pages: 2380-2385
- DOI
  10.11406/rinketsu.58.2380
- NAID
  130006308839
- ISSN
  0485-1439, 1882-0824
- Language
  Japanese
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21012, KAKENHI-PROJECT-16J02129, KAKENHI-PROJECT-16H06277
[Presentation] Unraveling heterogeneity of aged hematopoietic stem cells by single-cell RNA sequence analysis2021
- Author(s)
  Shuhei Koide, Motohiko Oshima, Akira Nishiyama, Koichi Murakami, Yaeko-Nakajima Takagi, Naoki Itokawa, Nozomi Yusa, Kazuaki Yokoyama, Kiyoshi Yamaguchi, Yoichi Furukawa, Arinobu Tojo, Tomohiko Tamura, Atsushi Iwama.
- Organizer
  第83回日本血液学会総会
- Data Source
  KAKENHI-PROJECT-21H02711
[Presentation] Myeloid/Natural Killer (NK) Cell Precursor Acute Leukemia As a Novel Distinctive Leukemia Entity2021
- Author(s)
  Akira Nishimura, Kazuaki Yokoyama, Masatoshi Takagi et al.
- Organizer
  第83回日本血液学会総会プレナリーセッション
- Data Source
  KAKENHI-PROJECT-21H02711
[Presentation] The impact of circulating tumor DNA status on acute myeloid leukemia and myelodysplastic syndromes with alloSCT: Interim results of a prospective study2020
- Author(s)
  Ogawa M, Yokoyama K, et al.
- Organizer
  46th EBMT2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 急性骨髄性白血病や骨髄異形成症候群において同種移植後の循環腫瘍DNA残存は再発を予測するバイオマーカーである2020
- Author(s)
  横山和明
- Organizer
  第82回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Cell free-DNA based detection of minimal residual disease post allogenic-stem cell transplantation in acute myeloid leukemia and myelodysplastic syndromes2020
- Author(s)
  Kazuaki Yokoyama, Nozomi Yusa, Mika Ito, Miho Ogawa, Kanya Kondoh, Eigo Shimizu, Seiya Imoto, Arinobu Tojo, Satoshi Takahashi
- Organizer
  7th US-Japan Workshop on Biomarkers for Cancer Early Detection
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 臨床シークエンスにて確定診断に至った慢性好中球性白血病の２例2019
- Author(s)
  小川弥穂, 横山和明, 塚田信弘, 余語孝夫3, 近藤幹也, 武井智美, 中村聡介, 伊藤美香, 小林麻子, 遊佐希, 山本茉子, 笠島理加, 清水英悟, 山口類, 井元清哉, 宮野悟, 東條有伸
- Organizer
  第81回日本血液学会学術集会 Presidential シンポジウム
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] 治療関連骨髄系腫瘍15例のゲノム解析と液体生検によるファウンダークローンの後方視的追跡2019
- Author(s)
  近藤幹也, 横山和明, 遊佐希, 伊藤美香, 清水英悟, 中村聡介, 小川弥穂, 武井智美, 小林麻子, 笠島理加, 和田結花, 山口類, 井元清哉, 長村登紀子, 内丸薫, 宮野悟, 東條有伸
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Cell free-DNA based detection of minimal residual disease post allogenic-stem cell transplantation in acute myeloid leukemia and myelodysplastic syndromes2019
- Author(s)
  1.Kazuaki Yokoyama, Nozomi Yusa, Mika Ito, Miho Ogawa, Kanya Kondoh, Eigo Shimizu, Seiya Imoto, Arinobu Tojo, Satoshi Takahashi
- Organizer
  7th US-Japan Workshop on Biomarkers for Cancer Early Detection (AMED-NCI)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] 治療関連骨髄系腫瘍15例のゲノム解析と液体生検によるファウンダークローンの後方視的追跡2019
- Author(s)
  近藤幹也, 横山和明, 遊佐希, 伊藤美香, 清水英悟, 中村聡介, 小川弥穂, 武井智美, 小林麻子, 笠島理加, 和田結花, 山口類, 井元清哉, 長村登紀子, 内丸薫, 宮野悟, 東條有伸
- Organizer
  第81回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] がんのプレシジョン・メディスンにおけるAI活用の試み2019
- Author(s)
  横山和明
- Organizer
  日本血液学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 腫瘍由来循環DNAを用いたAMLおよびMDSの移植後微小残存病変検出に関する後方視的解析2019
- Author(s)
  横山和明
- Organizer
  神奈川移植Forum
- Invited
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] The utility of exome sequence of circulating tumor DNA in drug-resistant and/or advanced phase chronic myeloid leukemia2019
- Author(s)
  omomi Takei, Kazuaki Yokoyama, Sousuke Nakamura, Miho Ogawa, Kanya Kondoh, Eigo Shimizu, Rika Kasajima, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
- Organizer
  The 78th Annual Meeting of the Japanese Cancer Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] The utility of exome sequence of circulating tumor DNA in drug-resistant and/or advanced phase chronic myeloid leukemia2019
- Author(s)
  Tomomi Takei, Kazuaki Yokoyama, Sousuke Nakamura, Miho Ogawa, Kanya Kondoh, Eigo Shimizu, Rika Kasajima, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 臨床シークエンスにて確定診断に至った慢性好中球性白血病の２例2019
- Author(s)
  小川弥穂, 横山和明, 塚田信弘, 余語孝夫3, 近藤幹也, 武井智美, 中村聡介, 伊藤美香, 小林麻子, 遊佐希, 山本茉子, 笠島理加, 清水英悟, 山口類, 井元清哉, 宮野悟, 東條有伸
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 血液がんのプレシジョン・メディスンにおけるAI活用の試み2019
- Author(s)
  横山和明
- Organizer
  第81回日本血液学会学術集会 Presidential シンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605
[Presentation] Circulating tumor DNA predicts post-allogeneic hematopoietic stem cell transplantation in AML and MDS2019
- Author(s)
  Nakamura S, Yokoyama K, Shimizu E, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Nagamura-Inoue T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, Tojo A
- Organizer
  Molecular Med Tri-Con
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 腫瘍由来循環DNAを用いたAMLおよびMDSの移植後微小残存病変検出に関する後方視的解析2019
- Author(s)
  横山和明
- Organizer
  神奈川移植Forum
- Invited
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Prognostic Impact of Circulating Tumor DNA Status Post-Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome2018
- Author(s)
  Nakamura S, Yokoyama K, Shimizu E, Yusa N, Kondoh K, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Inoue-Nagamura T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, Tojo A
- Organizer
  60th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Residual circulating tumor DNA status in relapse prediction post allogeneic hematopoietic stem cell transplantation2018
- Author(s)
  中村聡介、横山和明、遊佐希、近藤幹也、小川弥穂、武井智美、小林麻子、伊藤美香、神保光児、田上晋、磯部優理、小沼貴晶、加藤せい子、清水英悟、笠島理加、和田結花、山口類、井元清哉、長村登紀子、高橋聡、宮野悟、東條有伸
- Organizer
  第１８回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Circulating tumor DNA predicts relapse after allogeneic hematopoietic stem cell transplantation in AML and MDS2018
- Author(s)
  中村聡介、横山和明、近藤幹也、武井智美、清水英悟、笠島理加、山口類、井元清哉、宮野悟、東條有伸
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Residual circulating tumor DNA status in relapse prediction post allogeneic hematopoietic stem cell transplantation2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  第13回生命医科学研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia and myelodysplastic syndrome.2018
- Author(s)
  Nakamura S, Yokoyama K, Shimizu E, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, KasajimaR, Wada Y, Nagamura-Inoue T, RYamaguchi R, Takahashi S, Imoto S, Miyano S, Tojo A.
- Organizer
  60th ASH Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] イマチニブ単剤で速やかに細胞遺伝学的寛解を得たFIP1L1-PDGFRA陽性AMLの一例2018
- Author(s)
  近藤幹也、牧山純也、安藤匠平、水澤　舞、川俣豊隆、横山和明、安井　寛、今井陽一、東條有伸．
- Organizer
  第8回日本血液学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] Successful application of RHOA p.G17V for diagnosis and disease monitoring in a case of AITL2018
- Author(s)
  水澤　舞、小川弥穂、横山和明、川俣豊隆、安藤匠平、近藤幹也、武井智美、中村聡介、伊藤美香、遊佐希、笠島理加、清水英悟、牧山純也、安井寛、山口類、井本清哉、宮野悟、吉川賢忠、田中廣壽、今井陽一、東條有伸
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 湿疹続発性紅皮症を伴った低悪性度B細胞性リンパ腫．2018
- Author(s)
  安藤匠平、横山和明、水澤　舞、近藤幹也、牧山純也、川俣豊隆、安井　寛、今井陽一、高橋　聡、東條有伸．
- Organizer
  第8回日本血液学会関東甲信越地方会
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] 腫瘍由来循環DNAを用いたAMLおよびMDSの移植後微小残存病変の検出に関する後方視的解析2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  第80回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Impact of residual circulating tumor DNA status post allogeneic hematopoietic stem cell transplantation on outcome in acute myeloid leukemia and myelodysplastic syndrome2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  45th IMSUT Founding Commemorative Symposium
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Personalized Circulating Tumor DNA Dynamically Predicts Response and/or Relapse in Hematological Malignancies.2017
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Kobayashi M, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Furukawa Y, Nagamura-Inoue T, Miyano S, Tojo A.
- Organizer
  American Society of Hematology (ASH) 59th Annual Meeting and Exposition.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] 血中循環腫瘍DNAは造血器腫瘍の個別化バイオマーカーとなり得るか？2017
- Author(s)
  中村聡介、横山和明、遊佐　希、小林麻子、伊藤美香、小林真之、神保光児、小川弥穂、平野光人、武井智美、田上　晋、越智清純、磯部優理、川俣豊隆、小沼貴晶、加藤せい子、清水英悟、大野伸広、高橋　聡、山口　類、井元清哉、古川洋一、宮野　悟、今井陽一、東條有伸．
- Organizer
  第79回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] Cell lineage-oriented clinical sequencing unveils distinct clonal ontogeny of acute myeloid leukemia with myelodysplasia-related changes.2017
- Author(s)
  Yokoyama K, Yusa N, Kobayashi A, Kobayashi M, Kasajima R, Yui H, Shimizu E, Yamaguchi R, Imoto S, Furukawa Y, Miyano S, and Tojo A.
- Organizer
  American Association for Cancer Research (AACR) Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] A novel mutant WASp in X-linked neutropenia partially recapitulates defective neutrophil production through its expression in WASp-deficient NB4 Cells.2017
- Author(s)
  Kobayashi M, Chanda B, Futami M, Yamashita M, Hirano M, Yokoyama K, Imai Y, Shimizu E, Yusa N, Yamaguchi R, Imoto S, Miyano S, Tojo A.
- Organizer
  American Society of Hematology (ASH) 59th Annual Meeting and Exposition.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] Personalized Circulating Tumor DNA Predicts Relapse after Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome.2017
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Kobayashi M, Jimbo K, Tanoue S, Takaaki K, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Furukawa YNagamura-Inoue T, Takahashi S, , Miyano S, Tojo A.
- Organizer
  American Society of Hematology (ASH) 59th Annual Meeting and Exposition.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012
[Presentation] Exploratory introduction of cognitive computing to clinical sequencing in hematological malignancies2016
- Author(s)
  Kazuaki Yokoyama, et al
- Organizer
  The 78th Annual Meeting of the Japanese Society of Hematology
- Place of Presentation
  パシフィコ横浜
- Data Source
  KAKENHI-PROJECT-16K21012

1. Yamaguchi Rui (90380675)

# of Collaborated Projects: 1 results

# of Collaborated Products: 12 results
2. 井元清哉 (10345027)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
3. 木村晋也 (80359794)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 石井敬人 (90814294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 高橋直人 (80344753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 三浦昌朋 (30265194)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 大場雄介 (30333503)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. ARAYA Natsumi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. SATO Shinya

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. WASHIMI Kota

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 服部浩一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 井上大地

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 宮野悟

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

YOKOYAMA KAZUAKI 横山 和明

Research Projects

Research Products

Co-Researchers

TKI抵抗性CMLに対するエキソーム解析とFRET解析の統合による個別化治療の可能性

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whole genome and multiomics analysis of hairy cell leukemia japansese variantPrincipal Investigator

Principal Investigator

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Harnessing the single-cell biology and biomarker involving in the therapeutic response of patients with severe acute graft-versus-host disease undergoing mesenchymal stem cell transfusionPrincipal Investigator

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Study on statistical methods to integrate high-dimensional and heterogenous biomedical data for predicting and controlling disease progression

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Identification of deregulated mTORC1 signaling in advanced chronic myelogenous leukemiaPrincipal Investigator

Principal Investigator

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Research Institution

[Book] 令和３年度厚生労働省委託事業がんの全ゲノム解析に関する人材育成推進事業 テキスト4章2021

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[Book] 人工知能の臨床応用-血液疾患-,日本病院薬剤師会雑誌2018

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[Book] 人工知能ワトソンを用いた疾患診断. 感染炎症免疫2017

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[Book] 血液がんの臨床シークエンスにおける人工知能Watsonの活用. 医学のあゆみ2017

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[Book] 人口知能を用いた臨床シークエンス. 腫瘍内科2017

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[Book] 腫瘍内科2017

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[Journal Article] Explainable AI for Estimating Pathogenicity of Genetic Variants Using Large-Scale Knowledge Graphs.2023

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DOI

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[Journal Article] MDS cells impair osteolineage differentiation of MSCs via extracellular vesicles to suppress normal hematopoiesis.2022

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DOI

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[Journal Article] Anti-inflammatory effects of ruxolitinib on chronic neutrophilic leukemia harboring CSF3R-T618I mutation with bilateral renal abscesses.2022

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Data Source

[Journal Article] Repeated Lineage Switches in an Elderly Case of Refractory B-Cell Acute Lymphoblastic Leukemia With MLL Gene Amplification: A Case Report and Literature Review2022

Author(s)

YOKOYAMA KAZUAKI 横山和明

[Book] 令和３年度厚生労働省委託事業がんの全ゲノム解析に関する人材育成推進事業テキスト4章2021