YAMAGUCHI RUI 山口類

… Alternative Names

YAMAGUCHI Rui 山口類

山口類ヤマグチルイ

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Researcher Number	90380675
Affiliation (Current)	2022: 愛知県がんセンター(研究所), システム解析学分野, 分野長
Affiliation (based on the past Project Information) *help	2019 – 2022: 愛知県がんセンター(研究所), システム解析学分野, 分野長 2018: 愛知県がんセンター(研究所), 分野長, 分野長 2015 – 2018: 東京大学, 医科学研究所, 准教授 2010 – 2014: 東京大学, 医科学研究所, 講師 2013: 東京大学, 東京大学, 講師 2008: 東京大学, 医科学研究所, 講師 2006: 東京大学, 医科学研究所, 特任講師
Review Section/Research Field	Principal Investigator Bioinformatics/Life informatics / Basic Section 62010:Life, health and medical informatics-related / Life / Health / Medical informatics / Medium-sized Section 90:Biomedical engineering and related fields Except Principal Investigator Bioinformatics/Life informatics / Complex systems / Medium-sized Section 50:Oncology and related fields / Medical genome science / Life / Health / Medical informatics / Orthopaedic surgery … More / Basic Section 53010:Gastroenterology-related / Basic Section 56030:Urology-related / Basic Section 58030:Hygiene and public health-related: excluding laboratory approach / Basic Section 48040:Medical biochemistry-related / Basic Section 55020:Digestive surgery-related / Basic Section 55040:Respiratory surgery-related / Basic Section 50010:Tumor biology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related Less
Keywords	Principal Investigator バイオインフォマティクス / T細胞受容体 / 薬剤効果 / 状態空間モデル / 統計的モデリング / システム生物学 / データ解析 / 統計的時系列モデル / 薬剤応答 / 薬剤構造 … More / 時系列遺伝子発現データ / 免疫細胞シークエンスデータ解析 / 免疫細胞受容体レパトア解析 / B細胞受容体 / 免疫細胞集団シークエンス / 適応免疫 / 免疫細胞集団シークエンスデータ情報処理分野 / 病態予測 / 情報統合 / 異種多次元データ / 異種情報統合 / 有用情報抽出 / 微小残存病変 / 変異検出 / 病態遷移モデル / 個別変異データ / スパースモデリング / 病態予測モデル / 機械学習 / 一細胞シークエンス / シングルセルデータ解析 / ネットワーク推定 / 説明可能AI … More Except Principal Investigator がん / 遺伝子ネットワーク / システム生物学 / シミュレーション / バイオインフォマティクス / 統計的モデリング / ゲノム / 癌 / 膵癌 / PDXモデル / プロテオミクス / プロテオゲノミクス / ゼブラフィッシュ / がんワクチン / 遺伝子発現マイクロアレイデータ / 創薬ターゲット遺伝子 / Fenofibrate / Gefitinib / 漢方薬 / マイクロアレイ / タンパク質相互作用 / 自己分泌パスウェイ / ゲノム科学 / 遺伝統計学 / スーパーコンピュータ / シークエンス解析 / 薬剤応答パスウェイ / 動的モデル / パスウェイ解析 / ベイジアンネットワーク / ペトリネット / 状態空間モデル / パスウェイ解析 / ベトリネット / 薬剤応答パスウェィ / Bayesiamネットワーク / 疾患関連遺伝子 / 大腸がん / ヒストン / メチル基転移酵素 / 大腸癌 / 人工知能 / メディカルインフォマティクス / 個別化ゲノム医療 / シリコン・シークエンサー / 消化器癌 / 血液腫瘍 / シリコンシークエンサー / 肉腫 / ゲノム解析 / がんゲノム / 骨軟部腫瘍 / 融合遺伝子 / 整形外科 / 骨軟部肉腫 / EUS-FNA / 統合オミクスデータベース / 個別化医療 / マルチオミックス / がん組織 / PDX / CRISPRスクリーニング法 / シングルセルRNAシークエンス法 / 地理的格差 / 空間疫学 / がん対策 / 格差 / マイクロペプチド / 癌特異的抗原 / HLAリガンドーム / 患者由来Xenograft / Virtual dissectionモデル / がん微小環境 / PDXマウス / Virtual dissection / 腫瘍免疫 / 非小細胞肺癌 / 化学療法 / 難治がん / 個別化がんワクチン / HLAクラスI結合ペプチド / 免疫グロブリン結合タンパク質 / がん抗原 / HL Aリガンドーム / 自己抗体結合タンパク / 癌・精巣RNA / 化合物スクリーニング / 肺癌 / 腫瘍抗原 / T細胞 / 術後再発予防 Less

癌・精巣リボヌクレオタンパク質の機能解明と、新規抗がん剤創出
- Principal Investigator
  
  細野祥之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Okayama University
The determination of T-cell fate by different tumor antigens and prevention of post-operative recurrence of lung cancer
- Principal Investigator
  
  松下博和
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Aichi Cancer Center Research Institute
説明可能AIによる１細胞計測大規模ネットワークデータからの知識発見技術の開発Principal Investigator
- Principal Investigator
  
  山口類
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Aichi Cancer Center Research Institute
社会経済的格差に着目したがん対策に資する空間疫学的ビッグデータ解析研究
- Principal Investigator
  
  伊藤秀美
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
- Research Institution
  Aichi Cancer Center Research Institute
免疫一細胞データ解析による改変型T細胞受容体デザイン技術の開発Principal Investigator
- Principal Investigator
  
  山口類
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  Aichi Cancer Center Research Institute
In-depth surfaceome analysis of PDX models to develop innovative personalized therapies in pancreatic cancer
- Principal Investigator
  
  田口歩
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Aichi Cancer Center Research Institute
Establishment of precisoin medicine for malti-omics approaches using cancer tissue
- Principal Investigator
  
  植村元秀
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Fukushima Medical University
  Osaka University
ヒトとゼブラフィッシュの類似点・相違点を利用した、遺伝子と化合物スクリーニング
- Principal Investigator
  
  細野祥之
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Pioneering)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Development of clinical micropeptidome in cancer tissues
- Principal Investigator
  
  阿部雄一
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 48040:Medical biochemistry-related
- Research Institution
  Aichi Cancer Center Research Institute
Prediction of cancer microenvironment using deconvolution analysis
- Principal Investigator
  
  笠島理加
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kanagawa Cancer Center Research Institute
末梢血中循環腫瘍細胞を用いた非小細胞肺癌への化学療法による免疫原性細胞死の解析
- Principal Investigator
  
  高橋祐介
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55040:Respiratory surgery-related
- Research Institution
  Aichi Cancer Center Research Institute
個別化がんワクチン療法に向けた統合プロテオミクスによる新規がん抗原同定法の開発
- Principal Investigator
  
  田口歩
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 50:Oncology and related fields
- Research Institution
  Aichi Cancer Center Research Institute
Study on statistical methods to integrate high-dimensional and heterogenous biomedical data for predicting and controlling disease progressionPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Rui
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 62010:Life, health and medical informatics-related
- Research Institution
  Aichi Cancer Center Research Institute
  The University of Tokyo
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
Developments of methods for T-cell receptor sequence data analysis and understanding of diversities in the immune cellsPrincipal Investigator
- Principal Investigator
  
  Yamaguchi Rui
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  The University of Tokyo
Neodimensional exploration for cancer systems by supercomputing and innovative information technology
- Principal Investigator
  
  MIYANO SATORU
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Medical informatics infrastructure for personalized genomic medicine
- Principal Investigator
  
  Satoru Miyano
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Life / Health / Medical informatics
- Research Institution
  The University of Tokyo
Development of methods to extact kowledge from drug-stimulated gene expression time-coure compendium dataPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Rui
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
Functional analysis of a histone methyltransferase in colorectal cancer by comprehensive genome analysis
- Principal Investigator
  
  FURUKAWA Yoichi
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical genome science
- Research Institution
  The University of Tokyo
Development of Systems Cancer Research by Computation and Simulation
- Principal Investigator
  
  MIYANO SATORU
- Project Period (FY)
  2010 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
- Review Section
  
  Complex systems
- Research Institution
  The University of Tokyo
Drug-response pathway analysis methods based on network analysis
- Principal Investigator
  
  MIYANO Satoru
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
Development of method to extract drug effect by state space modelPrincipal Investigator
- Principal Investigator
  
  YAMAGUCHI Rui
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo
In Silico Search for Drug Target Pathways by Gene Networks
- Principal Investigator
  
  MIYANO Satoru
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bioinformatics/Life informatics
- Research Institution
  The University of Tokyo

[Book] 遺伝統計学と疾患ゲノムデータ解析（第2章-6: T細胞受容体レパトア解析）2018
- Author(s)
  井元清哉、長谷川嵩矩、山口類
- Total Pages
  272
- Publisher
  メディカルドゥ
- ISBN
  9784944157631
- Data Source
  KAKENHI-PROJECT-15K00399
[Book] Chapter2: A TCR sequence data analysis pipeline: Tcrip. In Immunopharmacogenomics. Nakamura, Y. (Ed.)2015
- Author(s)
  Yamaguchi R, Imoto S, Miyano S
- Total Pages
  17
- Publisher
  Springer Japan
- Data Source
  KAKENHI-PROJECT-15K00399
[Journal Article] Theoretical Foundation of the Performance of Phylogeny-Based Somatic Variant Detection2020
- Author(s)
  Moriyama Takuya、Imoto Seiya、Miyano Satoru、Yamaguchi Rui
- Journal Title
  
  Lecture Notes in Computer Science
  
  Volume: 12508 Pages: 87-101
- DOI
  10.1007/978-3-030-64511-3_9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H03329
[Journal Article] Variant analysis of prostate　cancer in Japanese patients and a new attempt to predict related biological　pathways2020
- Author(s)
  Kasajima R, Yamaguchi R, Shimizu E, Tamada Y, Niida A, Tremmel G, Kishida T,Aoki I, Imoto S, Miyano S, Uemura H, Miyagi Y
- Journal Title
  
  Oncol Rep.
  
  Volume: 43(3) Pages: 943-952
- DOI
  10.3892/or.2020.7481
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] Successful Clinical Sequencing by Molecular Tumor Board in an Elderly Patient With Refractory Sezary Syndrome2020
- Author(s)
  Hijikata K, Yokoyama K (co-1st and co-corresponding author), Yokoyama N, Matsubara Y, Shimizu E, Nakashima M, Yamagishi M, Ota Y, Lim L, Yamaguchi R, Ito M, Tanaka Y, Denda T, Tani K, Yotsuyanagi H, Imoto S, Miyano S, Uchimaru K, Tojo A.
- Journal Title
  
  JCO Precision Oncology
  
  Volume: 4 Pages: 534-560
- DOI
  10.1200/po.19.00254
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-17H01547, KAKENHI-PROJECT-18H03329, KAKENHI-PROJECT-19H03575, KAKENHI-PROJECT-18K08317, KAKENHI-PROJECT-19K16580
[Journal Article] Automatic sparse principal component analysis2020
- Author(s)
  Park Heewon、Yamaguchi Rui、Imoto Seiya、Miyano Satoru
- Journal Title
  
  Canadian Journal of Statistics
  
  Volume: Online first Pages: 1-24
- DOI
  10.1002/cjs.11579
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20402, KAKENHI-PROJECT-18H03329
[Journal Article] Nanopore basecalling from a perspective of instance segmentation2020
- Author(s)
  Zhang Y-Z, Akdemir A, Tremmel G, Imoto S, Miyano S, Shibuya T, Yamaguchi R.
- Journal Title
  
  BMC Bioinformatics
  
  Volume: 23;21(Suppl 3) Pages: 136-136
- DOI
  10.1186/s12859-020-3459-0
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-17H01693, KAKENHI-PROJECT-17K20023
[Journal Article] Global gene network exploration based on explainable artificial intelligence approach2020
- Author(s)
  Park Heewon、Maruhashi Koji、Yamaguchi Rui、Imoto Seiya、Miyano Satoru
- Journal Title
  
  PLOS ONE
  
  Volume: 15
- DOI
  10.1371/journal.pone.0241508
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K20402, KAKENHI-PROJECT-18H03328, KAKENHI-PROJECT-18H03329
[Journal Article] Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy2019
- Author(s)
  VanderWeele DJ, Finney R, Katayama K, Gillard M, Paner G, Imoto S, Yamaguchi R, Wheeler D, Lack J, Cam M, Pontier A, Nguyen YTM, Maejima K, Sasaki-Oku A, Nakano K, Tanaka H, Vander Griend D, Kubo M, Ratain MJ, Miyano S, Nakagawa H
- Journal Title
  
  European Urology Focus
  
  Volume: pii: S2405-4569(18) Pages: 416-424
- DOI
  10.1016/j.euf.2018.01.006
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-19K12215
[Journal Article] Accurate and Flexible Bayesian Mutation Call from Multi-Regional Tumor Samples.2019
- Author(s)
  Moriyama Takuya、Imoto Seiya、Miyano Satoru、Yamaguchi Rui
- Journal Title
  
  Springer Lecture Notes in Computer Science
  
  Volume: 11826 Pages: 47-61
- DOI
  10.1007/978-3-030-35210-3_4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18H03329, KAKENHI-PROJECT-17J08884
[Journal Article] An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review2019
- Author(s)
  Takeda R, Yokoyama K (corresponding author), Kobayashi S, Kawamata T, S Nakamura, Tomofusa F, Ito M, Yusa N, Shimizu E, Ohno N, Yamaguchi R, Imoto S, Miyano S, Uchimaru K, and Tojo A.
- Journal Title
  
  Case Reports in Hematology
  
  Volume: epub Pages: 4532434-4532434
- DOI
  10.1155/2019/4532434
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PROJECT-18H03329
[Journal Article] ALPHLARD-NT: Bayesian method for HLA genotyping and mutation calling through simultaneous analysis of normal and tumor whole-genome sequence data2019
- Author(s)
  Hayashi S, Moriyama T, Yamaguchi R, Mizuno S, Komura M, Miyano S, Nakagawa H, Imoto S
- Journal Title
  
  Journal of Computational Biology
  
  Volume: 26(9) Pages: 923-937
- DOI
  10.1089/cmb.2018.0224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03328
[Journal Article] Integrated exome and RNA sequencing of dedifferentiated liposarcoma.2019
- Author(s)
  Hirata Makoto、Matsubara Daisuke (21th) etc
- Journal Title
  
  Nat Commun.
  
  Volume: 10 Pages: 1-12
- DOI
  10.1038/s41467-019-13286-z
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07441, KAKENHI-PROJECT-19K07791, KAKENHI-PROJECT-19K09206, KAKENHI-PROJECT-19K12215, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-18H02933, KAKENHI-PROJECT-19H03444, KAKENHI-PROJECT-16K08672
[Journal Article] Virtual Grid Engine: a simulated grid engine environment for large-scale supercomputers2019
- Author(s)
  Ito S, Yadome M, Nishiki T, Ishiduki S, Inoue H, Yamaguchi R, Miyano S
- Journal Title
  
  BMC Bioinformatics.
  
  Volume: 20(Suppl 16) Pages: 591-591
- DOI
  10.1186/s12859-019-3085-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] A Bayesian model integration for mutation calling through data partitioning2019
- Author(s)
  Moriyama T, Imoto S, Hayashi S, Shiraishi Y, Miyano S, Yamaguchi R
- Journal Title
  
  Bioinformatics
  
  Volume: 35(21) Pages: 4247-4254
- DOI
  10.1093/bioinformatics/btz233
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] Prognostic impact of circulating tumor DNA status post-allogeneic hematopoietic stem cell transplantation in AML and MDS2019
- Author(s)
  Nakamura S, Yokoyama K (co-1st and co-corresponding author), Shimizu E, Yusa N, Kondoh K, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Inoue-Nagamura T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Blood
  
  Volume: 133 Pages: 2682-2695
- DOI
  10.1182/blood-2018-10-880690
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Virtual Grid Engine: Accelerating thousands of omics sample analyses using large-scale supercomputers2019
- Author(s)
  Ito S, Yadome M, Nishiki T, Ishiduki S, Inoue H, Yamaguchi R, Miyano S
- Journal Title
  
  IEEE BIBM 2018
  
  Volume: 印刷中
- DOI
  10.1109/bibm.2018.8621285
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] Development of an MSI-positive colon tumor with aberrant DNA methylation in a PPAP patient.2019
- Author(s)
  Yamaguchi K, Shimizu E, Yamaguchi R, Imoto S, Komura M, Hatakeyama S, Noguchi R, Takane K, Ikenoue T, Gohda Y, Yano H, Miyano S, Furukawa Y
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 64(8) Pages: 729-740
- DOI
  10.1038/s10038-019-0611-7
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-17H03575, KAKENHI-PROJECT-17K16530
[Journal Article] Accurate and Flexible Bayesian Mutation Call from Multi-regional Tumor Samples2019
- Author(s)
  Moriyama T, Imoto s, Miyano S, Yamaguchi R
- Journal Title
  
  Lecture Notes in Computer Science
  
  Volume: 11826 Pages: 47-61
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] Massively parallel sequencing of tenosynovial giant cell tumors reveals novel CSF1 fusion transcripts and novel somatic CBL mutations2019
- Author(s)
  Tsuda Yusuke、Matsubara Daisuke (5th) etc
- Journal Title
  
  Int J Cancer.
  
  Volume: 145 Pages: 3276-3284
- DOI
  10.1002/ijc.32421
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K07441, KAKENHI-PROJECT-19K12215, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-18H02933, KAKENHI-PROJECT-19H03444, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-18K15303
[Journal Article] The first case of elderly TCF3-HLF-positive B-cell acute lymphoblastic leukemia2019
- Author(s)
  Takeda R, Yokoyama K (corresponding author), Ogawa M, Kawamata T, Tomofusa F, Kondoh K, Tomomi T, Nakamura S, Ito M, Yusa N, Shimizu E, Ohno N, Uchimaru K, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Leukemia & Lymphoma
  
  Volume: 60 Pages: 2821-2824
- DOI
  10.1080/10428194.2019.1602267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K16605, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Different clonal dynamics of chronic myeloid leukaemia betwecn bone marrow and the central nervous system2018
- Author(s)
  Ogawa M, Yokoyama K, Hirano M, Jimbo K, Ochi K, Kawamata T, Ohno N, Shimizu E, Yokoyama N, Yamaguchi R, Imoto S, Uchimaru K, Takahashi N, Miyano S, Imai Y, Tojo A
- Journal Title
  
  Br J Haematol
  
  Volume: - Pages: 842-845
- DOI
  10.1111/bjh.15065
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K21012, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-15H05912
[Journal Article] Cell-lineage level-targeted sequencing to identify acute myeloid leukemia with myelodysplasia-related changes2018
- Author(s)
  Yokoyama K, Shimizu E, Yokoyama N, Nakamura S, Kasajima R, Ogawa M, Takei T,Ito M, Kobayashi A, Yamaguchi R, Imoto S, Miyano S, Tojo A
- Journal Title
  
  Blood Adv
  
  Volume: 2(19) Pages: 2513-2521
- DOI
  10.1182/bloodadvances.2017010744
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912
[Journal Article] Characterization of the B-cell receptor repertoires in peanut allergic subjects undergoing oral immunotherapy2018
- Author(s)
  Kiyotani K, Mai TH, Yamaguchi R, Yew PY, Kulis M, Orgel K, Imoto S, Miyano S, Burks AW, Nakamura Y
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 63(2) Pages: 239-248
- DOI
  10.1038/s10038-017-0364-0
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H02775, KAKENHI-PROJECT-15K00399
[Journal Article] Phenotype-Based Gene Analysis Allowed Successful Diagnosis of X-Linked Neutropenia Associated with a Novel Wasp Mutation. 2018 ; 97(2) : 367-69.2018
- Author(s)
  Kobayashi M, Yokoyama K, Shimizu E, Yusa N, Ito M, Yamaguchi R, Imoto S, Miyano S, and Tojo A.
- Journal Title
  
  Annals of Hematology
  
  Volume: 97 Issue: 2 Pages: 367-369
- DOI
  10.1007/s00277-017-3134-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K21012, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16J02129, KAKENHI-PROJECT-16H00660
[Journal Article] ALPHLARD: a Bayesian method for analyzing HLA genes from whole genome sequence data2018
- Author(s)
  Hayashi S, Yamaguchi R, Mizuno S, Komura M, Miyano S, Nakagawa H, Imoto S
- Journal Title
  
  BMC Genomics
  
  Volume: 19(1) Pages: 790-790
- DOI
  10.1186/s12864-018-5169-9
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03328
[Journal Article] Wide-spread ignorance on the treatment of subcutaneous malignant tumors; a questionnaire-based study.2018
- Author(s)
  Kikuta Kazutaka、Nakayama Robert、Yamaguchi Sayaka、Nishiwaki Yuuji、Susa Michiro、Nishimoto Kazumasa、Horiuchi Keisuke、Nakamura Masaya、Matsumoto Morio、Morioka Hideo
- Journal Title
  
  Jpn J Clin Oncol
  
  Volume: 48 Pages: 130-134
- DOI
  10.1093/jjco/hyx184
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10874, KAKENHI-PROJECT-16H02676
[Journal Article] Azacitidine effectively reduces TP53-mutant leukemic cell burden in sccondary acute myeloid leukemia after cord blood transplantation2018
- Author(s)
  Takei T, Yokoyama K, Nakamura S, Yusa N, Shimizu E, Kasajima R, Ogawa M, Tanoue S, Konuma T, Takahashi S, Kobayashi A, Yamazaki M, Yamaguchi R, Imoto S, Miyano S, Tojo A
- Journal Title
  
  Leuk Lymphoma
  
  Volume: In press Pages: 1-2
- DOI
  10.1080/10428194.2018.1443335
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K19570, KAKENHI-PROJECT-16H06277, KAKENHI-PLANNED-15H05912
[Journal Article] Circulating tumor DNA dynamically predicts response and/or relapse in patients with hematological malignancies2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Miyano S, Tojo A
- Journal Title
  
  International Journal of Hematology
  
  Volume: 108(4) Pages: 402-410
- DOI
  10.1007/s12185-018-2487-2
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-18H03329
[Journal Article] Identification of a p53-repressed gene module in breast cancer cells2017
- Author(s)
  Miyamoto T, Tanikawa C, Yodsurang V, Zhang YZ, Imoto S, Yamaguchi R, Miyano S, Nakagawa H, Matsuda K
- Journal Title
  
  Oncotarget
  
  Volume: 8(34) Pages: 55821-55836
- DOI
  10.18632/oncotarget.19608
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-16H01566
[Journal Article] The Transcriptional Landscape of p53 Signalling Pathway2017
- Author(s)
  Tanikawa C, Zhang YZ, Yamamoto R, Tsuda Y, Tanaka M, Funauchi Y, Mori J, Imoto S, Yamaguchi R, Nakamura Y, Miyano S, Nakagawa H, Matsuda K
- Journal Title
  
  EBioMedicine
  
  Volume: 20 Pages: 109-119
- DOI
  10.1016/j.ebiom.2017.05.017
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-16H01566
[Journal Article] Identification of a p53 target, CD137L, that mediates growth suppression and immune response of osteosarcoma cells2017
- Author(s)
  Yusuke Tsuda, Chizu Tanikawa, Takafumi Miyamoto, Makoto Hirata, Varalee Yodsurang, Yao-zhong Zhang, Seiya Imoto, Rui Yamaguchi, Satoru Miyano, Hiroshi Takayanagi, Hirotaka Kawano, Hidewaki Nakagawa, Sakae Tanaka, and Koichi Matsuda
- Journal Title
  
  Scientific Reports
  
  Volume: 7(1) Pages: 10739-10739
- DOI
  10.1038/s41598-017-11208-x
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05703
[Journal Article] Sequence-specific bias correction for RNA-seq data using recurrent neural networks2017
- Author(s)
  Zhang Y-Z, Yamaguchi R, Imoto S, Miyano S
- Journal Title
  
  BMC Genomics
  
  Volume: 18(Suppl 1) Pages: 1044-1044
- DOI
  10.1186/s12864-016-3262-5
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16H02676
[Journal Article] Analysis of the Infiltrative Features of Chordoma: The Relationship Between Micro-Skip Metastasis and Postoperative Outcomes2017
- Author(s)
  Akiyama Toru、Ogura Koichi、Gokita Tabu、Tsukushi Satoshi、Iwata Shintaro、Nakamura Tomoki、Matsumine Akihiko、Yonemoto Tsukasa、Nishida Yoshihiro、Saita Kazuo、Kawai Akira、Matsumoto Seiichi、Yamaguchi Takehiko
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 25 Pages: 912-919
- DOI
  10.1245/s10434-017-6268-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer.2017
- Author(s)
  Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
- Journal Title
  
  Oncotarget.
  
  Volume: 8(45) Pages: 78598-78613
- DOI
  10.18632/oncotarget.20009
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K07177, KAKENHI-PROJECT-16K10543, KAKENHI-PROJECT-17K10608, KAKENHI-PROJECT-17K10655, KAKENHI-PROJECT-17K19608, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-15K10150, KAKENHI-PROJECT-15K10170
[Journal Article] Clinical significance of T cell clonality and expression levels of immune-related genes in endometrial cancer2017
- Author(s)
  Ikeda Y, Kiyotani K, Yew PY, Sato S, Imai Y, Yamaguchi R, Miyano S, Fujiwara K, Hasegawa K, Nakamura Y
- Journal Title
  
  Oncology Reports
  
  Volume: 37(5) Pages: 2603-2610
- DOI
  10.3892/or.2017.5536
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K16865, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H02775, KAKENHI-PROJECT-15K00399
[Journal Article] OVarCall: Bayesian Mutation Calling Method Utilizing Overlapping Paired-End Reads2017
- Author(s)
  Moriyama T, Shiraishi Y, Chiba K, Yamaguchi R, Imoto S, Miyano S
- Journal Title
  
  IEEE Transactions on NanoBioscience
  
  Volume: 14 Pages: 116-122
- DOI
  10.1109/tnb.2017.2670601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16H02676
[Journal Article] The hypusine cascade promotes cancer progression and metastasis through the regulation of RhoA in squamous cell carcinoma2016
- Author(s)
  Muramatsu T, Kozaki KI, Imoto S, Yamaguchi R, Tsuda H, Kawano T, Fujiwara N, Morishita M, Miyano S, Inazawa J.
- Journal Title
  
  Oncol Lett
  
  Volume: - Pages: 3643-3649
- DOI
  10.1038/onc.2016.71
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K18401, KAKENHI-PROJECT-25250019, KAKENHI-PLANNED-15H05908, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-16K14630
[Journal Article] Characterization of the T cell repertoire by deep T cell receptor sequencing in tissues and blood from patients with advanced colorectal cancer.2016
- Author(s)
  Tamura K, Hazama S, Yamaguchi R, Imoto S, Takenouchi H, Inoue Y, Kanekiyo S, Shindo Y, Satoru Miyano S, Nakamura Y, Kiyotani K
- Journal Title
  
  Oncology Letters.
  
  Volume: 印刷中
- DOI
  10.3892/ol.2016.4465
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00399, KAKENHI-PROJECT-15K19894
[Journal Article] Characterization of T-cell Receptor Repertoire in Inflamed Tissues of Patients with Crohn's Disease Through Deep Sequencing2016
- Author(s)
  Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, Fang H, Yew PY, Marino SR, Miyano S, Nakamura Y, Kiyotani K
- Journal Title
  
  Inflamm Bowel Dis.
  
  Volume: 22(6) Pages: 1275-1285
- DOI
  10.1097/mib.0000000000000752
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H02775
[Journal Article] A likelihood-free filtering method via approximate Bayesian computation in evaluating biological simulation models2016
- Author(s)
  Hasegawa T, Niida A, Mori T, Shimamura T, Yamaguchi R, Miyano S, Akutsu T, Imoto S
- Journal Title
  
  Computational Statistics and Data Analysis
  
  Volume: 94 Pages: 63-74
- DOI
  10.1016/j.csda.2015.08.003
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K12139, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H06008, KAKENHI-PROJECT-25730173
[Journal Article] Characterization of T Cell Receptor Repertoire in Inflamed Tissues of Crohn’s Disease through Deep Sequencing2016
- Author(s)
  Chapman CG, Yamaguchi R, Tamura K, Weidner J, Imoto S, Kwon J, Marino SR, Miyano S, Nakamura Y, Kiyotani K
- Journal Title
  
  Inflammatory Bowel Diseases
  
  Volume: 印刷中
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00399
[Journal Article] A novel mouse model of intrahepatic cholangiocarcinoma induced by liver-specific Kras activation and Pten deletion2016
- Author(s)
  Ikenoue T, Terakado Y, Nakagawa H, Hikiba Y, Fujii T, Matsubara D, Noguchi R, Zhu C, Yamamoto K, Kudo Y, Asaoka Y, Yamaguchi K, Ijichi H, Tateishi K, Fukushima N, Maeda S, Koike K, Furukawa Y
- Journal Title
  
  Scientific Report
  
  Volume: 印刷中 Pages: 1-11
- DOI
  10.1038/srep23899
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26860206, KAKENHI-PROJECT-25280105, KAKENHI-PROJECT-25290045, KAKENHI-PROJECT-25460432, KAKENHI-PROJECT-26460425, KAKENHI-PROJECT-26461031, KAKENHI-PROJECT-26462136, KAKENHI-PROJECT-16K15422, KAKENHI-PROJECT-16K08672, KAKENHI-PROJECT-16K10558, KAKENHI-PROJECT-26860227, KAKENHI-PROJECT-15H04806
[Journal Article] Gene set differential analysis of time course expression profiles via sparse estimation in functional logistic model with application to time-dependent biomarker detection.2016
- Author(s)
  Kayano M, Matsui H, Yamaguchi R, Imoto S, Miyano S
- Journal Title
  
  Biostat
  
  Volume: 17 Pages: 235-248
- DOI
  10.1093/biostatistics/kxv037
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H02670, KAKENHI-PROJECT-24700290, KAKENHI-PROJECT-25730017, KAKENHI-PROJECT-25250017
[Journal Article] 8q24 Polymorphisms and Diabetes Mellitus Regulate Apolipoprotein A-IV in Colorectal Carcinogenesis.2016
- Author(s)
  Sugimachi K, Yamaguchi R, Eguchi H, Ueda M, Niida A, Sakimura S, Hirata H, Uchi R, Shinden Y, Iguchi T, Morita K, Yamamoto K, Miyano S, Mori M, Maehara Y, Mimori K
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 23(Suppl 4) Pages: 546-551
- DOI
  10.1245/s10434-016-5374-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-16H01576, KAKENHI-PROJECT-15H04921, KAKENHI-PROJECT-15K10168, KAKENHI-PROJECT-16K07177, KAKENHI-PROJECT-16K19197
[Journal Article] Reduced expression of APC-1B but not APC-1A by the deletion of promoter 1B is responsible for familial adenomatous polyposis2016
- Author(s)
  Yamaguchi K, Nagayama S, Shimizu E, Komura M, Yamaguchi R, Shibuya T, Arai M, Hatakeyama S, Ikenoue T, Ueno M, Miyano S, Imoto S, Furukawa Y
- Journal Title
  
  Scientific Report
  
  Volume: 6 Pages: 26011-26011
- DOI
  10.1038/srep26011
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-15H05912, KAKENHI-PUBLICLY-16H01569
[Journal Article] Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum2015
- Author(s)
  Tanakaya K, Furukawa Y, Nakamura Y, Hirata K, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Ishida H, Watanabe T, Sugihara K.
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 45(3) Pages: 307-310
- DOI
  10.1093/jjco/hyu218
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591984, KAKENHI-PROJECT-25280105
[Journal Article] Attenuated familial adenomatous polyposis with desmoids by an APC mutation2015
- Author(s)
  Ikenoue T, Yamaguchi K, Komura M, Imoto S, Yamaguchi R, Shimizu E, Kasuya S, Shibuya T, Hatakeyama S, Miyano S, Furukawa Y
- Journal Title
  
  Human Genome Variation
  
  Volume: 2 Pages: 15011-15011
- DOI
  10.1038/hgv.2015.11
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25280105
[Journal Article] Detection of APC mosaicism by next-generation sequencing in an FAP patient2015
- Author(s)
  Yamaguchi K, Komura M, Yamaguchi R, Imoto S, Shimizu E, Kasuya S, Shibuya T, Hatakeyama S, Takahashi N, Ikenoue T, Hata K, Tsurita G, Shinozaki M, Suzuki Y, Sugano S, Miyano S, Furukawa Y
- Journal Title
  
  Journal of Human Genetics
  
  Volume: 60(5) Pages: 227-231
- DOI
  10.1038/jhg.2015.14
- NAID
  40020462565
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26860206, KAKENHI-PROJECT-25280105
[Journal Article] Genomic data assimilation using a higher moment filtering technique for restoration of gene regulatory networks2015
- Author(s)
  Hasegawa T, Mori T, Yamaguchi R, Shimamura T, Miyano S, Imoto S, Akutsu T
- Journal Title
  
  MC Syst Biol
  
  Volume: 9(1) Pages: 14-14
- NAID
  120005749949
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] A novel APC mosaicism in a patient with familial adenomatous polyposis2015
- Author(s)
  Moriya Iwaizumi, Ken Sugimoto, et al.
- Journal Title
  
  Hum Genome Variation
  
  Volume: 10 Pages: 15057-15057
- DOI
  10.1038/hgv.2015.57
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25460948, KAKENHI-PROJECT-25860530, KAKENHI-PROJECT-26860206, KAKENHI-PROJECT-25280105
[Journal Article] Quantitative characterization of T-cell repertoire in allogeneic hematopoietic stem cell transplant recipients2015
- Author(s)
  Yew PY, Alachkar H, Yamaguchi R, Kiyotani K, Fang H, Yap KL, Liu HT, Wickrema A, Artz A, van Besien K, Imoto S, Miyano S, Bishop MR, Stock W, Nakamura Y
- Journal Title
  
  Bone Marrow Transplantation
  
  Volume: 50 Pages: 1227-1234
- DOI
  10.1038/bmt.2015.133
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K00399, KAKENHI-PLANNED-15H05912
[Journal Article] Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum2015
- Author(s)
  Yamaguchi T, Furukawa Y, Nakamura Y, Matsubara N, Ishikawa H, Arai M, Tomita N, Tamura K, Sugano K, Ishioka C, Yoshida T, Moriya Y, Ishida H, Watanabe T, Sugihara K;
- Journal Title
  
  Japanese Journal of Clinical Oncology
  
  Volume: 45(2) Pages: 153-159
- DOI
  10.1093/jjco/hyu190
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24591984, KAKENHI-PROJECT-25280105
[Journal Article] Molecular profiles of high grade and low grade pseudomyxoma peritonei.2015
- Author(s)
  Noguchi R, Yano H, Gohda Y, Suda R, Igari T, Ohta Y, Yamashita N, Yamaguchi K, Terakado Y, Ikenoue T, Furukawa Y
- Journal Title
  
  Cancer Medicine
  
  Volume: 4(12) Pages: 1809-1816
- DOI
  10.1002/cam4.542
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26860206, KAKENHI-PROJECT-25280105
[Journal Article] Elevated β-catenin pathway as a novel target for patients with resistance to EGF receptor targeting drugs.2015
- Author(s)
  Nakata A, Yoshida R, Yamaguchi R, Yamauchi M, Tamada Y, Fujita A, Shimamura T, Imoto S, Higuchi T, Nomura M, Kimura T, Nokihara H, Higashiyama M, Kondoh K, Nishihara H, Tojo A, Yano S, Miyano S, Gotoh N
- Journal Title
  
  Scientific Reports
  
  Volume: 5 Pages: 13076-13076
- DOI
  10.1038/srep13076
- NAID
  130005161518
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15K12139, KAKENHI-PROJECT-15K18426, KAKENHI-PROJECT-15K20965, KAKENHI-PLANNED-15H05912, KAKENHI-PROJECT-15H04294, KAKENHI-PROJECT-26640072, KAKENHI-PROJECT-25730173
[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014
- Author(s)
  Yamaguchi K, Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] An efficient data assimilation schema for restoration and extension of gene regulatory networks using time-course observation data2014
- Author(s)
  Hasegawa T, Mori T, Yamaguchi R, Imoto S, Miyano S, Akutsu T
- Journal Title
  
  J Comput Biol
  
  Volume: 21(11) Pages: 785-798
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Lung adenocarcinoma subtypes definable by lung development-related miRNA expression profiles in association with clinicopathologic features2014
- Author(s)
  Arima C, Kajino T, Tamada Y, Imoto S, Shimada Y, Nakatochi M, Suzuki M, Isomura H, Yatabe Y, Yamaguchi T, Yanagisawa K, Miyano S, Takahashi T
- Journal Title
  
  Carcinogenesis
  
  Volume: 35(10) Pages: 2224-2231
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Identification of two Wnt-responsive elements in the intron of RING Finger Protein 43 (RNF43) gene.2014
- Author(s)
  Takahashi N, Yamaguchi K, Ikenoue T, Fujii T, Furukawa Y.
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- DOI
  10.1371/journal.pone.0086582
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Identification of two Wnt-responsive elements in the intron of RING Finger Protein 43 (RNF43) gene2014
- Author(s)
  Takahashi N, Yamaguchi K, Ikenoue T, Fujii T, Furukawa Y
- Journal Title
  
  PLoS ONE
  
  Volume: 9
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Overexpression of cohesion establishment factor DSCC1 through E2F in colorectal cancer2014
- Author(s)
  Yamaguchi K, Rui Yamaguchi R, Takahashi N, Ikenoue T, Fujii T, Shinozaki M, Tsurita G, Hata K, Niida A, Imoto S, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  PLoS One
  
  Volume: 9
- DOI
  10.1371/journal.pone.0085750
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-25280105
[Journal Article] An efficient method of exploring simulation models by assimilating literature and biological observational data2014
- Author(s)
  Hasegawa T, Nagasaki M, Yamaguchi R, Imoto S, Miyano S
- Journal Title
  
  Biosystems
  
  Volume: 121 Pages: 54-66
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer2013
- Author(s)
  Takatsuno Y, Mimori K, Yamamoto K, Sato T, Niida A, Inoue H, Imoto S, Kawano S, Yamaguchi R, Toh H, Iinuma H, Ishimaru S, Ishii H, Suzuki S, Tokudome S, Watanabe M, Tanaka JI, Kudo SE, Mochizuki H, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Miyano S, Sugihara K, Mori M
- Journal Title
  
  Ann Surg Oncol.
  
  Volume: 20(4) Pages: 1395-1402
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Multi-omics approach for estimating metabolic networks using low-order partial correlations2013
- Author(s)
  Kayano M, Imoto S, Yamaguchi R, Miyano S.
- Journal Title
  
  J Comput Biol.
  
  Volume: 20(8) Pages: 571-582
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells.2013
- Author(s)
  Hiramoto T
- Journal Title
  
  Proc Natl Acad Sci U S A
  
  Volume: 110 Pages: 3023-3028
- DOI
  10.1073/pnas.1217039110
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591161, KAKENHI-PROJECT-23310137, KAKENHI-PROJECT-23650150, KAKENHI-PROJECT-23790126, KAKENHI-PROJECT-24390257, KAKENHI-PROJECT-24390272, KAKENHI-PROJECT-24659489, KAKENHI-PROJECT-25293231, KAKENHI-PLANNED-23106004
[Journal Article] Twist2 functions as a tumor suppressor in murine osteosarcoma cells2013
- Author(s)
  Ishikawa T, Shimizu T, Ueki A, Yamaguchi SI, Onishi N, Sugihara E, Kuninaka S, Miyamoto T, Morioka H, Nakayama R, Kobayashi E, Toyama Y, Mabuchi Y, Matsuzaki Y, Yamaguchi R, Miyano S, Saya H.
- Journal Title
  
  Cancer Sci.
  
  Volume: 104(7) Pages: 880-888
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Molecular features of triple negative breast cancer cells by genome-wide gene expression profiling analysis2013
- Author(s)
  Komatsu M, Yoshimaru T, Matsuo T, Kiyotani K, Miyoshi Y, Tanahashi T, Rokutan K, Yamaguchi R, Saito A, Imoto S, Miyano S, Nakamura Y, Sasa M, Shimada M, Katagiri T.
- Journal Title
  
  Int J Oncol
  
  Volume: 42(2) Pages: 478-506
- DOI
  10.3892/ijo.2012.1744
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-21119003, KAKENHI-PROJECT-22390146, KAKENHI-PROJECT-24501342, KAKENHI-PROJECT-25670352, KAKENHI-PLANNED-22134004, KAKENHI-PUBLICLY-23134504
[Journal Article] Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms2013
- Author(s)
  Kon A, Shih LY, Sanada M, Shiraishi Y, Okuno Y, Nagae G, Nishimoto A, Nowak D, Sato Y, Shimamura T, Tanaka H, Chiba K, Yamaguchi T, Otsu M, Obara N, Nakamaki T, Ishiyama K, Nolte F, Hofmann WK, Miyawaki S, Chiba S, Mori H, Nakauchi H, Koeffler HP, Aburatani H, Haferlach T, Shirahige K, Miyano S, Ogawa S.
- Journal Title
  
  Nature Genet.
  
  Volume: 45(10) Pages: 1232-1237
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells2013
- Author(s)
  Yoshimaru T, Komatsu M, Matsuo T, Chen YA, Murakami Y, Mizuguchi K, Mizohata E, Inoue T, Akiyama M, Yamaguchi R, Imoto S, Miyano S, Miyoshi Y, Sasa M, Nakamura Y, Katagiri T
- Journal Title
  
  Nature Commun.
  
  Volume: 4 Pages: 2443-2013
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Wnt3a stimulates maturation of impaired neutrophils developed from severe congenital neutropenia patient-derived pluripotent stem cells2013
- Author(s)
  Hiramoto T, Ebihara Y, Mizoguchi Y, Nakamura K, Yamaguchi K, Ueno K, Michizuki S, Yamamoto S, Nagasaki M, Furukawa Y, Tani K, Nakauchi H, Kobayashi M, Tsuji K
- Journal Title
  
  Proc. Natl. Acad. Sci. USA
  
  Volume: 110(8) Pages: 3023-3028
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Computational gene network analysis reveals TNF-induced angiogenesis2012
- Author(s)
  Ogami K, Yamaguchi R, Imoto S, Tamada Y, Araki H, Print C, Miyano S
- Journal Title
  
  BMC Systems Biology
  
  Volume: 6(Supple 2)
- DOI
  10.1186/1752-0509-6-s2-s12
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700292, KAKENHI-PLANNED-22134004
[Journal Article] Epidermal growth factor receptor tyrosine kinase defines criticalprognostic genes of stage I lung adenocarcinoma2012
- Author(s)
  後藤　典子
- Journal Title
  
  PLoS One
  
  Volume: 7
- DOI
  10.1371/journal.pone.0043923
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009, KAKENHI-PROJECT-22300099, KAKENHI-PROJECT-23390062, KAKENHI-PLANNED-22134004
[Journal Article] Identifying Gene pathways associated with cancer characteristics via sparse statistical methods2012
- Author(s)
  Kawano S, Shimamura T, Niida A, Imoto S, Yamaguchi R, Nagasaki M, Yoshida R, Print C, Miyano S
- Journal Title
  
  IEEE/ACM Transactions on Computational Biology and Bioinformatics
  
  Volume: 9(4) Pages: 966-972
- DOI
  10.1109/tcbb.2012.48
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24.2012
- Author(s)
  Ishimaru S, Iinuma H, et al
- Journal Title
  
  Ann. Surg.Oncol
  
  Volume: 21(in press) Pages: 21-21
- DOI
  10.1245/s10434-012-2278-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591734, KAKENHI-PROJECT-21592014, KAKENHI-PROJECT-22570172, KAKENHI-PROJECT-23390199, KAKENHI-PROJECT-24591984, KAKENHI-PLANNED-22134004, KAKENHI-PUBLICLY-23112514
[Journal Article] Identifying regulational alterations in gene regulatory networks by state space representation of vector autoregressive models and variational annealing2012
- Author(s)
  後藤　典子
- Journal Title
  
  BMC Genomics
  
  Volume: Suppl. 1,
- DOI
  10.1186/1471-2164-13-s1-s6
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009, KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-23390062
[Journal Article] Identification of genes up-regulated in ALK-positive and EGFR/KRAS/ALK-negative lung adenocarcinomas2012
- Author(s)
  後藤　典子
- Journal Title
  
  Cancer Res.
  
  Volume: 72 Pages: 100-111
- DOI
  10.1158/0008-5472.can-11-1403
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130009, KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-23390062
[Journal Article] Computational gene network analysis reveals TNF-induced angiogenesis2012
- Author(s)
  Ogami K, Yamaguchi R, Imoto S, Tamada Y, Araki H, Print C, Miyano S.
- Journal Title
  
  BMC Systems Biology
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24700292
[Journal Article] Comprehensive pharmacogenomic pathway screening by data assimilation2011
- Author(s)
  Hasegawa T, Yamaguchi R, Nagasaki M, Imoto S, Miyano S
- Journal Title
  
  Lecture Notes in Bioinformatics
  
  Volume: 6674 Pages: 160-171
- DOI
  10.1007/978-3-642-21260-4_18
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-22300099
[Journal Article] N-cadherin expression is a potential survival mechanism of gefitinib-resistant lung cancer cells2011
- Author(s)
  Yamauchi M, Yoshino I, Yamaguchi R, Shimamura T, Nagasaki M, Imoto S, Niida A, Koizumi F, Kohno T, Yokota J, Miyano S, Gotoh N
- Journal Title
  
  Am J Cancer Res
  
  Volume: 1(7) Pages: 828-833
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] MRG-binding protein contributes to development of colorectal cancer2011
- Author(s)
  Yamaguchi K, Sakai M, Kim J, Tsunesumi SI, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  Cancer Science
  
  Volume: 102(8) Pages: 1486-1492
- DOI
  10.1111/j.1349-7006.2011.01971.x
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] SiGN : large-scale gene network estimation environment for high performance computing2011
- Author(s)
  Tamada Y, Shimamura T, Yamaguchi R, Imoto S, Nagasaki M, Miyano S
- Journal Title
  
  Genome Informatics
  
  Volume: 25 Pages: 40-52
- NAID
  130004567842
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish2011
- Author(s)
  Fujii T, Tsunesumi S, Yamaguchi K, Watanabe S, Furukawa Y
- Journal Title
  
  PLoS One
  
  Volume: 6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] Inferring contagion in regulatory networks2011
- Author(s)
  Fujita A, Sato JR, Demas MAA, Yamaguchi R, Shimamura T, Ferreira CE, Sogayar, MC, Miyano S
- Journal Title
  
  IEEE/ACM Transactions on Computational Biology and Bioinformatics
  
  Volume: 8(2) Pages: 570-576
- DOI
  10.1109/tcbb.2010.40
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Frequent pathway mutations of splicing machinery in myelodysplasia., Nature2011
- Author(s)
  Kenichi Yoshida
- Journal Title
  
  Nature
  
  Volume: 478 Pages: 332-339
- DOI
  10.1038/nature10496
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22130002, KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-22390191, KAKENHI-PROJECT-22659058, KAKENHI-PROJECT-22790895, KAKENHI-PLANNED-23106004, KAKENHI-PUBLICLY-23118503, KAKENHI-PROJECT-23390269, KAKENHI-PROJECT-23659482, KAKENHI-PROJECT-23659533, KAKENHI-PROJECT-23791068, KAKENHI-PROJECT-23791075
[Journal Article] A novel network profiling analysis reveals system changes in epithelial-mesenchymal transition2011
- Author(s)
  Shimamura, T., Imoto, S., Shimada, Y., Hosono, Y., Niida, A., Nagasaki, M., Yamaguchi, R., Takahashi, T., Miyano, S
- Journal Title
  
  PLoS ONE
  
  Volume: 6
- DOI
  10.1371/journal.pone.0020804
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21249037, KAKENHI-PLANNED-22134004, KAKENHI-PLANNED-22134005
[Journal Article] MRG-binding protein contributes to colorectal cancer development2011
- Author(s)
  Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102(8) Pages: 1486-92
- NAID
  10030242078
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] SiGN-SSM open source parallel software for estimating gene networks with state space models2011
- Author(s)
  Tamada Y, Yamaguchi R, Imoto S, Hirose O, Yoshida R, Nagasaki M, Miyano S
- Journal Title
  
  Bioinformatics
  
  Volume: 27(8) Pages: 1172-1173
- DOI
  10.1093/bioinformatics/btr078
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004, KAKENHI-PROJECT-22300099, KAKENHI-PROJECT-22700308, KAKENHI-PROJECT-23700346
[Journal Article] SiGN large-scale gene network estimation environment for high performance computing2011
- Author(s)
  Tamada Y, Shimamura T, Yamaguchi R, Imoto S, Nagasaki M, Miyano S.
- Journal Title
  
  Genome Informatics
  
  Volume: 25巻 Pages: 40-52
- NAID
  130004567842
- URL
  http://www.jstage.jst.go.jp/article/gi/25/1/25_1_40/_article
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700308
[Journal Article] SiGN-SSM : open source parallel software for estimating gene networks with state space models2011
- Author(s)
  Tamada Y, Yamaguchi R, Imoto S, Hirose O, Yoshida R, Nagasaki M, Miyano S.
- Journal Title
  
  Bioinformatics
  
  Volume: 27 Pages: 1172-1173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700308
[Journal Article] Smyd3 is required for the development of cardiac and skeletal muscle in zebrafish2011
- Author(s)
  Fujii T, Tsunesumi S, Yamaguchi K, Watanabe S, & Furukawa Y
- Journal Title
  
  PLoS One
  
  Volume: 6(8)
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] MRG-binding protein contributes to colorectal cancer development2011
- Author(s)
  Yamaguchi K, Sakai M, Kim J, Tsunesumi S, Fujii T, Ikenoue T, Yamada Y, Akiyama Y, Muto Y, Yamaguchi R, Miyano S, Nakamura Y, Furukawa Y
- Journal Title
  
  Cancer Science
  
  Volume: 102 Pages: 1486-1492
- NAID
  10030242078
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23310137
[Journal Article] SiGN : large-scale gene network estimation environment for high performance computing2011
- Author(s)
  Tamada Y, Shimamura T, Yamaguchi R, Imoto S, Nagasaki M, Miyano S
- Journal Title
  
  Genome Informatics
  
  Volume: 25 Pages: 40-52
- NAID
  130004567842
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22700308
[Journal Article] Network-based predictions and simulations by biological state space mo dels : Search for drug mode of action2010
- Author(s)
  Yamaguchi, R., Imoto, S., Miyan o, S.
- Journal Title
  
  J.Computer Science and Technology
  
  Volume: 25(1) Pages: 131-153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300099
[Journal Article] Gene set-based module discovery decodes cis-regulatory codes governing diverse gene expression across human multiple tissues2010
- Author(s)
  Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Miyano, S.
- Journal Title
  
  PLoS ONE
  
  Volume: 5(6):e10910(掲載確定)
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Inferring dynamic gene networks under varying conditions for transcriptomic network comparison2010
- Author(s)
  Shimamura, T., Imoto, S., Yamaguchi, R., Nagasaki, M., Miyano, S.
- Journal Title
  
  Bioinformatics
  
  Volume: 26(8) Pages: 1064-1072
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Network-based predictions and simulations by biological state space models: Search for drug mode of action. J2010
- Author(s)
  Yamaguchi R, Imoto S, Miyano S
- Journal Title
  
  Computer Science and Technology
  
  Volume: 25(1) Pages: 131-153
- DOI
  10.1007/s11390-010-9311-7
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300099
[Journal Article] Discovering functional gene pathways associated with cancer heterogeneity via sparse supervised learning2010
- Author(s)
  Kawano, S., Shimamura, T., Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Yoshida, R., Print, C., Miyano, S.
- Journal Title
  
  Proc.IEEE 10th International Symposium on Bioinformatics & Bioengineering
  
  Pages: 253-258
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Identifying hidden confounders in gene networks by Bayesian networks2010
- Author(s)
  Higashigaki, T., Kojima, K., Yamaguchi, R., Inoue, M., Imoto, S., Miyano, S.
- Journal Title
  
  Proc.10th IEEE Bioinformatics and Bioengineering
  
  Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300099
[Journal Article] Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing2010
- Author(s)
  Fujimoto, A., Nakagawa, H., Hosono, N., Nakano, K., Abe, G., Boroevich, K.A., Nagasaki, M., Yamaguchi, R., Shibuya, T., Kubo, M., Miyano, S., Nakamura, Y., Tsunoda, T.
- Journal Title
  
  Nature Genetics
  
  Volume: 42 Pages: 931-936
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Collocation-based sparse estimation for constructing dynamic gene networks2010
- Author(s)
  Shimamura, T., Imoto, S., Nagasaki, M., Yamauchi, M., Yamaguchi, R., Fujita, A., Tamada, Y, Gotoh, N., Miyano, S.
- Journal Title
  
  Genome Informatics
  
  Volume: 24 Pages: 164-178
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Model-free unsupervised gene set screening based on information enrichment in expression profiles2010
- Author(s)
  Niida, A., Imoto, S., Yamaguchi, R., Nagasaki, M., Fujita, A., Shimamura, T., Miyano, S.
- Journal Title
  
  Bioinformatics
  
  Volume: 26(24) Pages: 3090-3097
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Identifying hidden confounders in gene networks by Bayesian networks2010
- Author(s)
  Higashigaki, T., Kojima, K., Yamaguchi, R., Inoue, M., Imoto, S., Miyano, S.
- Journal Title
  
  Proc.10th IEEE Bioinformatics and Bioengineering
  
  Pages: 168-173
- Peer Reviewed
- Data Source
  KAKENHI-PLANNED-22134004
[Journal Article] Identifying hidden confounders in gene networks by Bayesian networks. Proc.2010
- Author(s)
  Higashigaki T, Kojima K, Yamaguchi R, Inoue M, Imoto S, Miyano S.
- Journal Title
  
  10th IEEE Bioinformatics and Bioengineering
  
  Pages: 168-173
- URL
  http://doi.ieeecomputersociety.org/10.1109/BIBE.2010.35
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300099
[Journal Article] Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine2009
- Author(s)
  Watanabe-Fukuda, Y., Yamamoto, M., Miura, N., Fukutake, M., Ishige, A., Yamaguchi, R., Nagasaki, M., Saito, A., Imoto, S., Miyano, S., Takeda, J., Watanabe, K.
- Journal Title
  
  J.Gastroenterology 44(5)
  
  Pages: 380-389
- NAID
  10025174631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Orengedokuto and berberine improve indomethacin-induced small intestinal injury via adenosine2009
- Author(s)
  Watanabe, Y., Yamamoto, M., Miura, N., Fukutake, M., Ishige, A., Yamaguchi, R., Nagasaki, M., Saito, A., Imoto, S., Miyano, S., Takeda, J., Watanabe, K.
- Journal Title
  
  J. Gastroenterology (印刷中)
- NAID
  10025174631
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Predicting differences in gene regulatory systems by state space models2008
- Author(s)
  Yamaguchi, R., Imoto, S., Yamauchi, M., Nagasaki, M., Yoshida, R., Shimamura, T., Hatanaka, Y., Ueno, K., Higuchi, T., Gotoh, N., Miyano, S.
- Journal Title
  
  Genome Informatics 21
  
  Pages: 101-113
- NAID
  130003997534
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Statistical absolute evaluation of gene ontology terms with gene expression data2007
- Author(s)
  Gupta, P.K., Yoshida, R., Imoto, S., Yamaguchi, R., Miyano, S.
- Journal Title
  
  Lecture Notes in Bioinformatics 4463
  
  Pages: 146-157
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Identification of activated transcription factors from microarray gene expression data of Kampo-medicine treated mice2007
- Author(s)
  Yamaguchi, R., Yamamoto, M., Imoto, S., Nagasaki, M., Yoshida, R., Tsujii, K., Ishiga, A., Asou, H., Watanabe, K., Miyano, S.
- Journal Title
  
  Genome Informatics 18
  
  Pages: 119-129
- NAID
  130003812136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Identification of activated transcription factors from microarray gene expression data of Kampo-medicine treated mice2007
- Author(s)
  Yamaguchi, R., Yamamoto, M., Imoto, S., Nagasaki, M. Ybshida, R., Tsujii, K., Ishiga, A., Asou, H., Watanabe, K., Miano, S.
- Journal Title
  
  Genome Informatics 18
  
  Pages: 119-129
- NAID
  130003812136
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18300097
[Journal Article] Genetic alterations in Japanese extrahepatic biliary tract cancer
- Author(s)
  Noguchi R, Yamaguchi K, Ikenoue T, Terakado Y, Ohta Y, Yamashita N, Kainuma O, Yokoi S, Maru Y, Nagase H, Furukawa Y. Genetic alterations in Japanese extrahepatic biliary tract cancer
- Journal Title
  
  Oncology Letters
  
  Volume: 印刷中
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25280105
[Presentation] Theoretical Foundation of the Performance of Phylogeny-Based Somatic Variant Detection2020
- Author(s)
  Moriyama Takuya、Imoto Seiya、Miyano Satoru、Yamaguchi Rui
- Organizer
  International Symposium on Mathematical and Computational Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 治療関連骨髄系腫瘍15例のゲノム解析と液体生検によるファウンダークローンの後方視的追跡2019
- Author(s)
  近藤幹也, 横山和明, 遊佐希, 伊藤美香, 清水英悟, 中村聡介, 小川弥穂, 武井智美, 小林麻子, 笠島理加, 和田結花, 山口類, 井元清哉, 長村登紀子, 内丸薫, 宮野悟, 東條有伸
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 臨床シークエンスにて確定診断に至った慢性好中球性白血病の２例2019
- Author(s)
  小川弥穂, 横山和明, 塚田信弘, 余語孝夫3, 近藤幹也, 武井智美, 中村聡介, 伊藤美香, 小林麻子, 遊佐希, 山本茉子, 笠島理加, 清水英悟, 山口類, 井元清哉, 宮野悟, 東條有伸
- Organizer
  日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Accurate and Flexible Bayesian Mutation Call from Multi-regional Tumor Samples2019
- Author(s)
  Moriyama Takuya、Imoto Seiya、Miyano Satoru、Yamaguchi Rui
- Organizer
  International Symposium on Mathematical and Computational Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] The utility of exome sequence of circulating tumor DNA in drug-resistant and/or advanced phase chronic myeloid leukemia2019
- Author(s)
  Tomomi Takei, Kazuaki Yokoyama, Sousuke Nakamura, Miho Ogawa, Kanya Kondoh, Eigo Shimizu, Rika Kasajima, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Arinobu Tojo
- Organizer
  日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Circulating tumor DNA predicts post-allogeneic hematopoietic stem cell transplantation in AML and MDS2019
- Author(s)
  Nakamura S, Yokoyama K, Shimizu E, Yusa N, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Nagamura-Inoue T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, Tojo A
- Organizer
  Molecular Med Tri-Con
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Prognostic Impact of Circulating Tumor DNA Status Post-Allogeneic Hematopoietic Stem Cell Transplantation in Acute Myeloid Leukemia and Myelodysplastic Syndrome2018
- Author(s)
  Nakamura S, Yokoyama K, Shimizu E, Yusa N, Kondoh K, Ogawa M, Takei T, Kobayashi A, Ito M, Isobe M, Konuma T, Kato S, Kasajima R, Wada Y, Inoue-Nagamura T, Yamaguchi R, Takahashi S, Imoto S, Miyano S, Tojo A
- Organizer
  60th ASH Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Circulating tumor DNA predicts relapse after allogeneic hematopoietic stem cell transplantation in AML and MDS2018
- Author(s)
  中村聡介、横山和明、近藤幹也、武井智美、清水英悟、笠島理加、山口類、井元清哉、宮野悟、東條有伸
- Organizer
  第77回日本癌学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Residual circulating tumor DNA status in relapse prediction post allogeneic hematopoietic stem cell transplantation2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  第13回生命医科学研究所ネットワーク国際シンポジウム
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Successful application of RHOA p.G17V for diagnosis and disease monitoring in a case of AITL2018
- Author(s)
  水澤　舞、小川弥穂、横山和明、川俣豊隆、安藤匠平、近藤幹也、武井智美、中村聡介、伊藤美香、遊佐希、笠島理加、清水英悟、牧山純也、安井寛、山口類、井本清哉、宮野悟、吉川賢忠、田中廣壽、今井陽一、東條有伸
- Organizer
  第80回日本血液学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Impact of residual circulating tumor DNA status post allogeneic hematopoietic stem cell transplantation on outcome in acute myeloid leukemia and myelodysplastic syndrome2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  45th IMSUT Founding Commemorative Symposium
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] Residual circulating tumor DNA status in relapse prediction post allogeneic hematopoietic stem cell transplantation2018
- Author(s)
  中村聡介、横山和明、遊佐希、近藤幹也、小川弥穂、武井智美、小林麻子、伊藤美香、神保光児、田上晋、磯部優理、小沼貴晶、加藤せい子、清水英悟、笠島理加、和田結花、山口類、井元清哉、長村登紀子、高橋聡、宮野悟、東條有伸
- Organizer
  第１８回東京大学生命科学シンポジウム
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 腫瘍由来循環DNAを用いたAMLおよびMDSの移植後微小残存病変の検出に関する後方視的解析2018
- Author(s)
  Nakamura S, Yokoyama K, Yusa N, Kondo K, Ogawa M, Takei T, Kobayashi A, Ito M, Jimbo K, Tanoue S, Isobe M, Konuma T, Kato S, Shimizu E, Kasajima R, Wada Y, Yamaguchi R, Imoto S, Nagamura-Inoue T, Takahashi S, Miyano S, Tojo A
- Organizer
  第80回日本血液学会学術総会
- Data Source
  KAKENHI-PROJECT-18H03329
[Presentation] 大腸癌患者におけるペプチドワクチン特異的T細胞のTCRシークエンス解析2017
- Author(s)
  清谷一馬、田村賢司、山口類、井元清哉、竹之内寛子、宮野悟、硲彰一、中村祐輔
- Organizer
  日本癌学会学術総会
- Place of Presentation
  神奈川県横浜市
- Data Source
  KAKENHI-PROJECT-15K00399
[Presentation] MYD88 L265P Mutated Splenic Marginal Zone Lymphoma associated with Cold Agglutinin Disease2016
- Author(s)
  越智清純、横山和明、遊佐希、伊藤美香、小林真之、小川弥穂、竹田玲奈、武井智美、川俣豊隆、福山朋房、大野伸広、高橋聡、山口類、内丸薫、井元清哉、古川洋一、宮野悟、東條有伸
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25280105
[Presentation] WASPの一アミノ酸変異に起因するX連鎖重症好中球減少症の本邦第一例2016
- Author(s)
  小林真之、横山和明、遊佐希、川俣豊隆、大野伸広、清水英悟、山口類、井元清哉、古川洋一、宮野悟、東條有伸
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25280105
[Presentation] コグニティブ・コンピューティングの造血器腫瘍臨床シーケンスへの試験的導入2016
- Author(s)
  横山和明、遊佐希、伊藤美香、小林真之、小川弥穂、竹田玲奈、武井智美、越智清純、川俣豊隆、小沼貴晶、加藤せい子、清水英悟、小山尚彦、大野伸広、高橋聡、内丸薫、山口類、井元清哉、古川洋一、宮野悟、東條有伸
- Organizer
  第78回日本血液学会学術集会
- Place of Presentation
  パシフィコ横浜(神奈川県横浜市)
- Year and Date
  2016-10-13
- Data Source
  KAKENHI-PROJECT-25280105
[Presentation] Modeling of dynamic drug effect on gene networks2013
- Author(s)
  Maruyama Y, Yamaguchi R, Imoto S, Miyano S
- Organizer
  The 13th Annual International Workshop on Bioinformatics and Systems Biology (IBSB2013)
- Place of Presentation
  京都大学宇治キャンパス
- Data Source
  KAKENHI-PROJECT-24700292
[Presentation] Modeling of dynamic drug effect on gene networks2013
- Author(s)
  Maruyama Y, Yamaguchi R, Imoto S, Miyano S.
- Organizer
  The 13^<th> Annual International Workshop on Bioinformatics and Systems Biology
- Place of Presentation
  京都大学
- Year and Date
  2013-08-01
- Data Source
  KAKENHI-PROJECT-24700292
[Presentation] リングフィンガープロテイン43の転写調節機構および下流遺伝子解析2013
- Author(s)
  髙橋則彦　山口貴世志　池上恒雄　古川洋一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] Idenntification of a single nucleotide polymorphism associated with SIAH2 expression2013
- Author(s)
  Seham Elgazzar 髙橋則彦　山口貴世志　前仏均　片桐豊雅　池上恒雄　中村祐輔　古川洋一
- Organizer
  第72回日本癌学会学術総会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] DSCC1 is a novel biomarker for chemo-resistant colorectal cancer.2013
- Author(s)
  Kiyoshi Yamaguchi, Rui Yamaguchi, Masaru Shinozaki, GIichiro Tsurita, Keisuke Hata, Seiya Imoto, Satoru Miyano, Yusuke Nakamura, Yoichi Furukawa
- Organizer
  The 9th AACR-JCA Joint Conference
- Place of Presentation
  Maui HI, USA
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] Computational gene network analysis reveals TNF-induced angiogenesis2012
- Author(s)
  尾上健太郎、山口類、井元清哉、玉田嘉紀、荒木啓充、Cristin Print、宮野悟
- Organizer
  The 23rd International Conference on Genome Informatics (GIW2012)
- Place of Presentation
  台湾、台南市
- Data Source
  KAKENHI-PROJECT-24700292
[Presentation] Estimation of dynamic drug effects on gene modules from time-course transcriptome data by using state-space mode2012
- Author(s)
  Rui Yamaguchi, Seiya Imoto, Mai Yamauchi, Asuka Nakata, Kunihiko Hinohara, Yoshinori Tamada, Ryo Yoshida, Teppei Shimamura, Masao Nagasaki, Noriko Gotoh, Satoru Miyano
- Organizer
  X-Gen Congress & Expo
- Place of Presentation
  Hilton hotel,米国(San Diego)
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Estimation of dynamic drug effects on gene modules from time-course transcriptome data by using state-space model2012
- Author(s)
  Rui Yamaguchi, 他
- Organizer
  X-Gen Congress & Expo
- Place of Presentation
  Hilton hotel,米国(San Diego)
- Year and Date
  2012-03-06
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Computational gene network analysis reveals TNF-induced angiogenesis2012
- Author(s)
  尾上健太郎、山口類、井元清也、玉田嘉紀、荒木啓充、Cristin Pring、宮野悟
- Organizer
  The 23^<rd> International Conference on Genome Informatics
- Place of Presentation
  台湾
- Year and Date
  2012-12-12
- Data Source
  KAKENHI-PROJECT-24700292
[Presentation] Identifying the target of histone methyltransferase SMYD3 in colorectal cancer cells2012
- Author(s)
  山口貴世志、池上恒雄、宮野悟、中村祐輔、古川洋一
- Organizer
  第71回日本癌学会学術総会
- Place of Presentation
  ロイトン札幌（札幌）
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] DSCC1 promotes survival of colorectal cancer cells through the inhibition of BCL2 expression2012
- Author(s)
  Kiyoshi Yamaguchi, Rui Yamaguchi, Masaru Shinozaki, GIichiro Tsurita, Keisuke Hata, Seiya Imoto, Satoru Miyano, Yusuke Nakamura, Yoichi Furukawa
- Organizer
  The 8th, International Symposium on Cancer Research and Therapy
- Place of Presentation
  東京会館（東京）
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] Identification of dissimilarities in high-dimensional gene regulatory systems by predicted discrepancies from state space model2011
- Author(s)
  Yamaguchi R
- Organizer
  Joint Meeting of the 2011 Taipei International Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC
- Place of Presentation
  Academia Sinica, Taipei, Taiwan(招待講演)
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-22300099
[Presentation] Defective in sister chromatoid cohesion 1 homolog (DSCC1), a novel target of E2F1 is overexpressed in colorectal cancer2011
- Author(s)
  山口貴世志、藤井智明、池上恒雄、中村祐輔、古川洋一
- Organizer
  第70回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2011-10-04
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] MRGBP (C20orf20) contributes to development of colorectal cancer2011
- Author(s)
  Kiyoshi Yamaguchi, Michihiro Sakai, Joohun Kim, Yoshinao Yamada, Yoshiyuki Akiyama, Yusuke Nakamura, Yoichi Furukawa
- Organizer
  The 102th. Annual meeting of American Association for Cancer Research
- Place of Presentation
  Orlando FL, USA
- Year and Date
  2011-04-04
- Data Source
  KAKENHI-PROJECT-23310137
[Presentation] Identification of dissimilarities in high-dimensional gene regulatory systems by predicted discrepancies from state space model2011
- Author(s)
  Rui Yamaguchi
- Organizer
  The Joint Meeting of the 2011 Taipei International Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC
- Place of Presentation
  Academia Sinica,台湾(台北)(招待講演)
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Identification of dissimilarities in high-dimensional gene regulatory systems by predicted discrepancies from state space model2011
- Author(s)
  Yamaguchi R
- Organizer
  Joint Meeting of the 2011 TaipeiInternational Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC
- Place of Presentation
  Academia Sinica,Taipei,Taiwan
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-22300099
[Presentation] Identification of dissimilarities in high-dimensional gene regulatory systems by predicted discrepancies from state space model2011
- Author(s)
  Rui Yamaguchi
- Organizer
  The Joint Meeting of the 2011 Taipei International Statistical Symposium and 7th Conference of the Asian Regional Section of the IASC
- Place of Presentation
  Academia Sinica、台湾
- Year and Date
  2011-12-17
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] 状態空間モデリングによる遺伝子発現制御に関わる動的薬剤効果の推定2010
- Author(s)
  山口類, 井元清哉, 山内麻衣, 島村徹平, 後藤典子, 宮野悟
- Organizer
  2010年度統計関連学会連合大会
- Place of Presentation
  早稲田大学東京
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Detection of Systematic Differences in Gene Regulations and Extraction of Gene Signatures by Using State Space Model2010
- Author(s)
  Rui Yamaguchi
- Organizer
  2010 NCTS International Conference on Probability and Statistics with Applications in Biology
- Place of Presentation
  National Center for Theoretical Sciences, Taiwan
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Detection of Systematic Differences in Gene Regulations and Extraction of Gene Signatures by Using State Space Model2010
- Author(s)
  Rui Yamaguchi
- Organizer
  2010 NCTS International Conference on Probability and Statistics with Applications in Biology
- Place of Presentation
  National Center for Theoretical Sciences,台湾
- Year and Date
  2010-07-15
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] 動的予測による遺伝子間制御関係の異常探索2010
- Author(s)
  山口類
- Organizer
  大分統計談話会第42回大会
- Place of Presentation
  富士通大分ソフトウェアラボラトリ大分
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] 状態空間モデリングによる遺伝子発現制御に関わる動的薬剤効果の推定2010
- Author(s)
  山口類、井元清哉、山内麻衣、島村徹平、後藤典子、宮野悟
- Organizer
  2010年度統計関連学会連合大会
- Place of Presentation
  早稲田大学、東京
- Year and Date
  2010-09-08
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] 動的予測による遺伝子間制御関係の異常探索2010
- Author(s)
  山口類
- Organizer
  大分統計談話会第42回大会
- Place of Presentation
  富士通大分ソフトウェアラボラトリ、大分
- Year and Date
  2010-10-21
- Data Source
  KAKENHI-PROJECT-22700308
[Presentation] Identification of Oncogenic Co-regulators using Infinite Relational Models
- Author(s)
  Yoichi Chikahara, Atsushi Niida, Rui Yamaguchi, Seiya Imoto, Satoru Miyano
- Organizer
  The 15th International Conference on Systems Biology (ICSB) 2014
- Place of Presentation
  メルボルン(オーストラリア)
- Year and Date
  2014-09-14 – 2014-09-18
- Data Source
  KAKENHI-PLANNED-22134004

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YAMAGUCHI RUI 山口 類

YAMAGUCHI Rui 山口 類

山口 類 ヤマグチ ルイ

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説明可能AIによる１細胞計測大規模ネットワークデータからの知識発見技術の開発Principal Investigator

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免疫一細胞データ解析による改変型T細胞受容体デザイン技術の開発Principal Investigator

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Study on statistical methods to integrate high-dimensional and heterogenous biomedical data for predicting and controlling disease progressionPrincipal Investigator

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Developments of methods for T-cell receptor sequence data analysis and understanding of diversities in the immune cellsPrincipal Investigator

YAMAGUCHI RUI 山口類

YAMAGUCHI Rui 山口類

山口類ヤマグチルイ