Akiyama Toru 秋山達

… Alternative Names

AKIYAMA Toru 秋山達

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Researcher Number	40376471
Other IDs
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2022: 自治医科大学, 医学部, 教授 2014 – 2016: 自治医科大学, 医学部, 准教授 2012 – 2013: 自治医科大学, 医学部, 講師 2009: 東京大学, 医学部附属病院, 助教 2008: 東大, 医学部附属病院, 助教 2007: The University of Tokyo, 医学部・附属病院, 助教 2005 – 2006: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 悪性腫瘍 / 創薬 / がん治療 / 腫瘍治療 / 腫瘍診断 / ゲノム変異 / 腫瘍原生 / 腫瘍原生遺伝子変異 / プレシジョンメディスン / 遺伝子治療 … More / ゲノム探索 / precision medecine / がん遺伝子 / 希少がん / 脊索腫 / inorganic phosphate / Bcl-2 family molecule / enchondral ossification / apoptosis / 分子生物学 / 軟骨分化 / 無機リン酸 / Bcl-2ファミリー / 内軟骨性骨化 / アポトーシス / 化学療法 / 新規治療法開発 / 肉腫 / 血管内皮細胞増殖因子 / 骨吸収 / 血管新生阻害因子 / 骨代謝 / 抗がん剤 / 破骨細胞 / 軟骨肉腫 / 色素上皮由来因子 / キメラ遺伝子 / 分子標的薬 … More Except Principal Investigator 骨軟部腫瘍 / 骨軟部肉腫 / 整形外科 / ゲノム / 癌 / 融合遺伝子 / がんゲノム / ゲノム解析 / 肉腫 / 転移 / 局所浸潤 / MMP9 / 軟骨肉腫 / KLF5 / 骨・軟部腫瘍学 / 治療 / 性ホルモン / 骨肉腫 Less

The whole genome analysis to rule out responsible mutation inducing chordomaPrincipal Investigator
- Principal Investigator
  
  Akiyama Toru
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
The study of novel chondrosarcoma therapy by PEDFPrincipal Investigator
- Principal Investigator
  
  Akiyama Toru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Jichi Medical University
Novel therapeutic strategy for osteosarcoma using sex hormones
- Principal Investigator
  
  KAWANO Hirotaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
軟骨肉腫の浸潤・転移における転写因子KLF5の役割の解明
- Principal Investigator
  
  篠田裕介
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発Principal Investigator
- Principal Investigator
  
  秋山達
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
The analysis of the mechanism of chondrocyte differentiation and apoptosisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Toru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2020 2018 2017 2016 2012 2010 2009 2008 Other

All Journal Article Presentation Other

[Journal Article] Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan2020
- Author(s)
  Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y
- Journal Title
  
  Nat Med
  
  Volume: 26 Issue: 4 Pages: 542-548
- DOI
  10.1038/s41591-020-0785-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-16H02676
[Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases2020
- Author(s)
  Ishigaki K, Akiyama M, Kanai M, Takahashi A, Kawakami E, Sugishita H, Sakaue S, Matoba N, Low SK, Okada Y, Yamaji T, et al
- Journal Title
  
  Nature Genetics
  
  Volume: 52 Issue: 7 Pages: 669-679
- DOI
  10.1038/s41588-020-0640-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10655, KAKENHI-PROJECT-20K07709, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18H02931, KAKENHI-PROJECT-18H02932, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-19H03881, KAKENHI-PROJECT-19K22525, KAKENHI-PROJECT-19K17962, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03695, KAKENHI-PROJECT-20H03943, KAKENHI-PROJECT-18H02940
[Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020
- Author(s)
  Terao Chikashi、Suzuki Akari、Momozawa Yukihide、Akiyama Masato、Ishigaki Kazuyoshi、Yamamoto Kazuhiko、Matsuda Koichi、Murakami Yoshinori、McCarroll Steven A.、Kubo Michiaki、Loh Po-Ru、Kamatani Yoichiro
- Journal Title
  
  Nature
  
  Volume: 584 Issue: 7819 Pages: 130-135
- DOI
  10.1038/s41586-020-2426-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676
[Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018
- Author(s)
  Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y
- Journal Title
  
  Nat Genet
  
  Volume: 50 Issue: 3 Pages: 390-400
- DOI
  10.1038/s41588-018-0047-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-16H05378, KAKENHI-PROJECT-17H04251
[Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population2017
- Author(s)
  Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M and Kamatani Y
- Journal Title
  
  Nat Genet
  
  Volume: 49 Issue: 10 Pages: 1458-1462
- DOI
  10.1038/ng.3951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09464, KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H01557, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670
[Journal Article] Analysis of the Infiltrative Features of Chordoma: The Relationship Between Micro-Skip Metastasis and Postoperative Outcomes2017
- Author(s)
  Akiyama Toru、Ogura Koichi、Gokita Tabu、Tsukushi Satoshi、Iwata Shintaro、Nakamura Tomoki、Matsumine Akihiko、Yonemoto Tsukasa、Nishida Yoshihiro、Saita Kazuo、Kawai Akira、Matsumoto Seiichi、Yamaguchi Takehiko
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 25 Issue: 4 Pages: 912-919
- DOI
  10.1245/s10434-017-6268-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Best practices for the Management of Local-regional Recurrent Chordoma. A Position Paper by the Chordoma Global Consensus Group.2017
- Author(s)
  Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S,
- Journal Title
  
  Ann Oncol.
  
  Volume: Epib Issue: 6 Pages: 1230-1242
- DOI
  10.1093/annonc/mdx054
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Reliability and validity of a Japanease-language and culturally adapted version of the Musculoskeletal Tumor Society scoring system for the lower extremity.2016
- Author(s)
  Iwata S, Uehara K, Ogura K, Akiyama T, Shinoda Y, Yonemoto T, Kawai A
- Journal Title
  
  Clin Orthop Relat Res
  
  Volume: 474(9) Issue: 9 Pages: 2044-2052
- DOI
  10.1007/s11999-016-4880-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-15K10388
[Journal Article] Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas.2016
- Author(s)
  Ishimaru D, Gotoh M, Takayama S, Kosaki R, Matsumoto Y, Narimatsu H, Sato T, Kimata K, Akiyama H, Shimizu K, Matsumoto K.
- Journal Title
  
  BMC Genet.
  
  Volume: 17 Issue: 1 Pages: 52-52
- DOI
  10.1186/s12863-016-0359-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01841, KAKENHI-PROJECT-16H02676
[Journal Article] Inferior gluteal artery detection at the greater sciatic notch with a computer-assisted navigation system during pelvic and sacral tumor resection.2016
- Author(s)
  Akiyama T, Kanda S, Maeda A, Saita K.
- Journal Title
  
  Comput Assist Surg (Abingdon)
  
  Volume: 21(1) Issue: 1 Pages: 18-24
- DOI
  10.3109/24699322.2016.1174305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts.2010
- Author(s)
  Akiyama T, Kawano H, et al.
- Journal Title
  
  J Pharm Pharmacol
  
  Volume: 62 Pages: 470-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] PEDF regulates osteoclasts via osteoprotegerin and RANKL2010
- Author(s)
  Akiyama T, Kawano H, et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 391 Pages: 789-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts.2010
- Author(s)
  Akiyama T, Kawano H, 他
- Journal Title
  
  J Pharm Pharmacol. 62(4)
  
  Pages: 470-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] PEDF regulates osteoclasts via osteoprotegerin and RANKL.2010
- Author(s)
  Akiyama T, Kawano H, 他
- Journal Title
  
  Biochem Biophys Res Commun. 391(1)
  
  Pages: 789-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Serum acid phosphatase can be a useful tumour marker for giant cell tumour of bone.2009
- Author(s)
  Goto T, Kawano H, Akiyama T, Shinoda Y, Okuma T, Et al.
- Journal Title
  
  Arch Orthop Trauma Surg. 129(12)
  
  Pages: 1641-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Juxtacortical chondroma of the sacrum.2008
- Author(s)
  Akiyama T, Shinoda Y, Kawano H, 他
- Journal Title
  
  J Orthop Sci. 13(5)
  
  Pages: 476-80
- NAID
  10024301798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Presentation] 骨・軟部悪性腫瘍患者における症候性静脈血栓塞栓症発症のリスクファクター　-骨軟部肉腫治療研究会(JMOG)前向き観察研究-2016
- Author(s)
  岩田慎太郎、米本司、川井章、平賀博明、外堀司、秋山達、角永茂樹、篠田裕介、末原義之、綿貫宗則、上田孝文
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16H02676
[Presentation] The PEDF suppresses osteoclast differentiation, bone resorption activity and survival via osteoprotegerin induction2012
- Author(s)
  Toru Akiyama, Jonathan Clark, Peter Choong
- Organizer
  The American Society for Bone and Mineral Research 2012
- Place of Presentation
  アメリカ、ミネアポリス
- Data Source
  KAKENHI-PROJECT-24592243
[Presentation] Tranilast, N-(3,4-dimethoxycinnamoyl) suppresses the progression of desmoid tumor.2010
- Author(s)
  Kawano H, Akiyama T, Shinoda Y, Okuma T, Kobayashi H
- Organizer
  In vitro analysis and interim report of our clinical trial-8th Asia Pacific Musculosteletal Tumor Society Meeting.
- Place of Presentation
  Cebu, Philippines.
- Data Source
  KAKENHI-PROJECT-20591749
[Presentation] Clinical outcome of 6 cases with tumor induced osteomalacia diagnosed by venous sampling for fibroblast growth factor (FGF) 23.2010
- Author(s)
  Okuma T, Shinoda Y, Akiyama T, Kawano H
- Organizer
  8th Asia Pacific Musculosteletal Tumor Society Meeting.
- Place of Presentation
  Cebu, Philippines.
- Data Source
  KAKENHI-PROJECT-20591749
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1. KAWANO Hirotaka (20345218)

# of Collaborated Projects: 4 results

# of Collaborated Products: 8 results
2. KADONO Yuho (70401065)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. KOBAYASHI Hiroshi (20407951)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. TANAKA Sakae (50282661)

# of Collaborated Projects: 2 results

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5. SHINODA Yusuke (80456110)

# of Collaborated Projects: 2 results

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6. OKUMA Tomotake (90534909)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
7. Matsuda Koichi (90401257)

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8. 川井章 (90252965)

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9. SAITA Kazuo (20241995)

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10. CHUNG Ungil (30345053)

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11. 小倉浩一 (20583115)

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35. 馬場一郎 (60330073)

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37. 末原義之 (70509405)

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38. 國定俊之 (80346428)

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46. 吉川秀樹 (60191558)

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47. 中紀文 (90601964)

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48. 岡本健 (30414113)

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49. 五嶋孝博 (20272544)

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50. 岩田慎太郎 (90549685)

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51. 山口岳彦 (80245125)

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52. SATO Takashi

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53. YAMAJI Taiki

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54. SUZUKI Akari

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55. 峯岸直子

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56. 鎌谷洋一郎

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59. 寺尾知可史

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Akiyama Toru 秋山 達

AKIYAMA Toru 秋山 達

Research Projects

Research Products

Co-Researchers

The whole genome analysis to rule out responsible mutation inducing chordomaPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study of novel chondrosarcoma therapy by PEDFPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Novel therapeutic strategy for osteosarcoma using sex hormones

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

軟骨肉腫の浸潤・転移における転写因子KLF5の役割の解明

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The analysis of the mechanism of chondrocyte differentiation and apoptosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of the Infiltrative Features of Chordoma: The Relationship Between Micro-Skip Metastasis and Postoperative Outcomes2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Best practices for the Management of Local-regional Recurrent Chordoma. A Position Paper by the Chordoma Global Consensus Group.2017

Author(s)

Journal Title

Akiyama Toru 秋山達

AKIYAMA Toru 秋山達

[Presentation] 骨・軟部悪性腫瘍患者における症候性静脈血栓塞栓症発症のリスクファクター　-骨軟部肉腫治療研究会(JMOG)前向き観察研究-2016