Akiyama Toru 秋山達

… Alternative Names

AKIYAMA Toru 秋山達

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Researcher Number	40376471
Other IDs
Affiliation (Current)	2022: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2017 – 2021: 自治医科大学, 医学部, 教授 2014 – 2016: 自治医科大学, 医学部, 准教授 2012 – 2013: 自治医科大学, 医学部, 講師 2009: 東京大学, 医学部附属病院, 助教 2008: 東大, 医学部附属病院, 助教 2007: The University of Tokyo, 医学部・附属病院, 助教 2005 – 2006: 東京大学, 医学部附属病院, 助手
Review Section/Research Field	Principal Investigator Orthopaedic surgery / Basic Section 50020:Tumor diagnostics and therapeutics-related Except Principal Investigator Orthopaedic surgery
Keywords	Principal Investigator 悪性腫瘍 / 分子標的薬 / キメラ遺伝子 / 色素上皮由来因子 / 軟骨肉腫 / 破骨細胞 / 抗がん剤 / 骨代謝 / 血管新生阻害因子 / がん治療 … More / 骨吸収 / 血管内皮細胞増殖因子 / 創薬 / 肉腫 / 新規治療法開発 / 化学療法 / アポトーシス / 内軟骨性骨化 / Bcl-2ファミリー / 無機リン酸 / 軟骨分化 / 分子生物学 / apoptosis / enchondral ossification / Bcl-2 family molecule / inorganic phosphate / 脊索腫 / ゲノム探索 / 遺伝子治療 / プレシジョンメディスン / 腫瘍原生 / ゲノム変異 / 希少がん / 腫瘍診断 / 腫瘍治療 … More Except Principal Investigator 骨軟部腫瘍 / 骨肉腫 / 性ホルモン / 治療 / 骨・軟部腫瘍学 / KLF5 / 軟骨肉腫 / MMP9 / 局所浸潤 / 転移 / 肉腫 / ゲノム解析 / がんゲノム / 融合遺伝子 / 癌 / ゲノム / 整形外科 / 骨軟部肉腫 Less

希少がんである脊索腫における腫瘍原生並びに治療標的となるゲノム変異の探索Principal Investigator
- Principal Investigator
  
  秋山達
- Project Period (FY)
  2018 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma
- Principal Investigator
  
  Matsuda Koichi
- Project Period (FY)
  2016 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
The study of novel chondrosarcoma therapy by PEDFPrincipal Investigator
- Principal Investigator
  
  Akiyama Toru
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Jichi Medical University
Novel therapeutic strategy for osteosarcoma using sex hormones
- Principal Investigator
  
  KAWANO Hirotaka
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
軟骨肉腫の浸潤・転移における転写因子KLF5の役割の解明
- Principal Investigator
  
  篠田裕介
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発Principal Investigator
- Principal Investigator
  
  秋山達
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo
The analysis of the mechanism of chondrocyte differentiation and apoptosisPrincipal Investigator
- Principal Investigator
  
  AKIYAMA Toru
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  The University of Tokyo

All 2020 2018 2017 2016 2012 2010 2009 2008

All Journal Article Presentation

[Journal Article] Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan2020
- Author(s)
  Sakaue S, Kanai M, Karjalainen J, Akiyama M, Kurki M, Matoba N, Takahashi A, Hirata M, Kubo M, Matsuda K, Murakami Y; FinnGen, Daly MJ, Kamatani Y, Okada Y
- Journal Title
  
  Nature Medicine
  
  Volume: 26 Pages: 542-548
- DOI
  10.1038/s41591-020-0785-8
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05911, KAKENHI-PROJECT-19H01021, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-16H02676
[Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility lociacross different diseases2020
- Author(s)
  Ishigaki K, Akiyama M, Kohno T, Shiraishi K, Momozawa Y, Matsuda K, Daigo Y, Kubo M, Kamatani Y.
- Journal Title
  
  Nature Genetics
  
  Volume: 52 Pages: 669-679
- DOI
  10.1038/s41588-020-0640-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K10655, KAKENHI-PROJECT-20K07709, KAKENHI-PROJECT-20K08288, KAKENHI-PROJECT-16H02468, KAKENHI-PROJECT-18H02894, KAKENHI-PLANNED-17H06419, KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-18H04053, KAKENHI-PROJECT-20H00543, KAKENHI-PROJECT-18H02688, KAKENHI-PROJECT-18H02931, KAKENHI-PROJECT-18H02932, KAKENHI-PROJECT-18H02940, KAKENHI-PROJECT-19H03559, KAKENHI-PROJECT-19H03881, KAKENHI-PROJECT-19K22525, KAKENHI-PROJECT-19K17962, KAKENHI-PROJECT-16H06277, KAKENHI-PROJECT-20H03695, KAKENHI-PROJECT-20H03943
[Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020
- Author(s)
  Terao Chikashi、Suzuki Akari、Momozawa Yukihide、Akiyama Masato、Ishigaki Kazuyoshi、Yamamoto Kazuhiko、Matsuda Koichi、Murakami Yoshinori、McCarroll Steven A.、Kubo Michiaki、Loh Po-Ru、Kamatani Yoichiro
- Journal Title
  
  Nature
  
  Volume: 584 Pages: 130-135
- DOI
  10.1038/s41586-020-2426-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H05285, KAKENHI-PROJECT-16H02676
[Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018
- Author(s)
  Kanai M, Akiyama M, Takahashi A, Matoba N, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Kubo M, Okada Y, Kamatani Y
- Journal Title
  
  Nature Genetics
  
  Volume: 50 Pages: 390-400
- DOI
  10.1038/s41588-018-0047-6
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670, KAKENHI-PROJECT-16H05378, KAKENHI-PROJECT-17H04251
[Journal Article] Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones2017
- Author(s)
  Kobayashi H, Akiyama T, Okuma T, Shinoda Y, Oka H, Ito N, Fukumoto S, Tanaka S, Kawano H.
- Journal Title
  
  Computer assisted surgery (Abingdon, England)
  
  Volume: 12 Pages: 1-14
- DOI
  10.1080/24699322.2017.1282044
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-15K19529, KAKENHI-PROJECT-15K15536
[Journal Article] Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma2017
- Author(s)
  Kobayashi Hiroshi、Okuma Tomotake、Oka Hiroyuki、Hirai Toshihide、Ohki Takahiro、Ikegami Masachika、Sawada Ryoko、Shinoda Yusuke、Akiyama Toru、Sato Kenji、Abe Satoshi、Kawano Hirotaka、Goto Takahiro、Tanaka Sakae
- Journal Title
  
  International Journal of Clinical Oncology
  
  Volume: 23 Pages: 368-374
- DOI
  10.1007/s10147-017-1199-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.2017
- Author(s)
  Akiyama M, Okada Y, Kanai M, Takahashi A, Momozawa Y, Ikeda M, Iwata N, Ikegawa S, Hirata M, Matsuda K, Iwasaki M, Yamaji T, Sawada N, Hachiya T, Tanno K, Shimizu A, Hozawa A, Minegishi N, Tsugane S, Yamamoto M, Kubo M and Kamatani Y
- Journal Title
  
  Nature Genetics
  
  Volume: 49 Pages: 1458-1462
- DOI
  10.1038/ng.3951
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K09464, KAKENHI-PLANNED-15H05911, KAKENHI-PUBLICLY-16H01566, KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-17H01557, KAKENHI-PROJECT-17H03596, KAKENHI-PROJECT-15H05670
[Journal Article] Prevalence and clinical outcomes of hip fractures and subchondral insufficiency fractures of the femoral head in patients with tumour-induced osteomalacia2017
- Author(s)
  Kobayashi Hiroshi、Ito Nobuaki、Akiyama Toru、Okuma Tomotake、Kinoshita Yuka、Ikegami Masachika、Shinoda Yusuke、Fukumoto Seiji、Tanaka Sakae、Kawano Hirotaka
- Journal Title
  
  Int Orthop
  
  Volume: 41 Pages: 2597-2603
- DOI
  10.1007/s00264-017-3610-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-15K15536
[Journal Article] Cross-cultural adaptation and validation of the Japanese version of the Toronto Extremity Salvage Score (TESS) for patients with malignant musculoskeletal tumors in the upper extremities2017
- Author(s)
  Akiyama T, Uehara K, Ogura K, Shinoda Y, Iwata S, Saita K, Tanzawa Y, Nakatani F, Yonemoto T, Kawano H, Davis AM, Kawai A.
- Journal Title
  
  Journal of Orthopaedic Science
  
  Volume: 22(1) Pages: 127-132
- DOI
  10.1016/j.jos.2016.09.012
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-15K10388
[Journal Article] Analysis of the Infiltrative Features of Chordoma: The Relationship Between Micro-Skip Metastasis and Postoperative Outcomes2017
- Author(s)
  Akiyama Toru、Ogura Koichi、Gokita Tabu、Tsukushi Satoshi、Iwata Shintaro、Nakamura Tomoki、Matsumine Akihiko、Yonemoto Tsukasa、Nishida Yoshihiro、Saita Kazuo、Kawai Akira、Matsumoto Seiichi、Yamaguchi Takehiko
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 25 Pages: 912-919
- DOI
  10.1245/s10434-017-6268-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Best practices for the Management of Local-regional Recurrent Chordoma. A Position Paper by the Chordoma Global Consensus Group.2017
- Author(s)
  Stacchiotti S, Gronchi A, Fossati P, Akiyama T, Alapetite C, Baumann M, Blay JY, Bolle S, Boriani S, Bruzzi P, Capanna R, Caraceni A, Casadei R, Colia V, Debus J, Delaney T, Desai A, Dileo P, Dijkstra S, Doglietto F, Flanagan A, Froelich S,
- Journal Title
  
  Ann Oncol.
  
  Volume: Epib
- DOI
  10.1093/annonc/mdx054
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Reliability and Validity of a Japanese-language and Culturally Adapted Version of the Musculoskeletal Tumor Society Scoring System for the Lower Extremity.2016
- Author(s)
  Iwata S, Uehara K, Ogura K, Akiyama T, Shinoda Y, Yonemoto T, Kawai A
- Journal Title
  
  Clin Orthop Relat Res.
  
  Volume: 474(9) Pages: 2044-2052
- DOI
  10.1007/s11999-016-4880-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676, KAKENHI-PROJECT-26293342, KAKENHI-PROJECT-15K10388
[Journal Article] Large-scale mutational analysis in the EXT1 and EXT2 genes for Japanese patients with multiple osteochondromas.2016
- Author(s)
  Ishimaru D, Gotoh M, Takayama S, Kosaki R, Matsumoto Y, Narimatsu H, Sato T, Kimata K, Akiyama H, Shimizu K, Matsumoto K.
- Journal Title
  
  BMC Genet.
  
  Volume: 17 Pages: 52-52
- DOI
  10.1186/s12863-016-0359-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H01841, KAKENHI-PROJECT-16H02676
[Journal Article] Inferior gluteal artery detection at the greater sciatic notch with a computer-assisted navigation system during pelvic and sacral tumor resection.2016
- Author(s)
  Akiyama T, Kanda S, Maeda A, Saita K.
- Journal Title
  
  Comput Assist Surg (Abingdon)
  
  Volume: 21(1) Pages: 18-24
- DOI
  10.3109/24699322.2016.1174305
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H02676
[Journal Article] Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts.2010
- Author(s)
  Akiyama T, Kawano H, et al.
- Journal Title
  
  J Pharm Pharmacol
  
  Volume: 62 Pages: 470-476
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] PEDF regulates osteoclasts via osteoprotegerin and RANKL2010
- Author(s)
  Akiyama T, Kawano H, et al.
- Journal Title
  
  Biochem Biophys Res Commun
  
  Volume: 391 Pages: 789-794
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Systemic RANK-Fc protein therapy is efficacious against primary osteosarcoma growth in a murine model via activity against osteoclasts.2010
- Author(s)
  Akiyama T, Kawano H, 他
- Journal Title
  
  J Pharm Pharmacol. 62(4)
  
  Pages: 470-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] PEDF regulates osteoclasts via osteoprotegerin and RANKL.2010
- Author(s)
  Akiyama T, Kawano H, 他
- Journal Title
  
  Biochem Biophys Res Commun. 391(1)
  
  Pages: 789-94
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Serum acid phosphatase can be a useful tumour marker for giant cell tumour of bone.2009
- Author(s)
  Goto T, Kawano H, Akiyama T, Shinoda Y, Okuma T, Et al.
- Journal Title
  
  Arch Orthop Trauma Surg. 129(12)
  
  Pages: 1641-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Journal Article] Juxtacortical chondroma of the sacrum.2008
- Author(s)
  Akiyama T, Shinoda Y, Kawano H, 他
- Journal Title
  
  J Orthop Sci. 13(5)
  
  Pages: 476-80
- NAID
  10024301798
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20591749
[Presentation] 骨・軟部悪性腫瘍患者における症候性静脈血栓塞栓症発症のリスクファクター　-骨軟部肉腫治療研究会(JMOG)前向き観察研究-2016
- Author(s)
  岩田慎太郎、米本司、川井章、平賀博明、外堀司、秋山達、角永茂樹、篠田裕介、末原義之、綿貫宗則、上田孝文
- Organizer
  第89回日本整形外科学会学術総会
- Place of Presentation
  パシフィコ横浜（神奈川県・横浜市）
- Year and Date
  2016-05-12
- Data Source
  KAKENHI-PROJECT-16H02676
[Presentation] The PEDF suppresses osteoclast differentiation, bone resorption activity and survival via osteoprotegerin induction2012
- Author(s)
  Toru Akiyama, Jonathan Clark, Peter Choong
- Organizer
  The American Society for Bone and Mineral Research 2012
- Place of Presentation
  アメリカ、ミネアポリス
- Data Source
  KAKENHI-PROJECT-24592243
[Presentation] Tranilast, N-(3,4-dimethoxycinnamoyl) suppresses the progression of desmoid tumor.2010
- Author(s)
  Kawano H, Akiyama T, Shinoda Y, Okuma T, Kobayashi H
- Organizer
  In vitro analysis and interim report of our clinical trial-8th Asia Pacific Musculosteletal Tumor Society Meeting.
- Place of Presentation
  Cebu, Philippines.
- Data Source
  KAKENHI-PROJECT-20591749
[Presentation] Clinical outcome of 6 cases with tumor induced osteomalacia diagnosed by venous sampling for fibroblast growth factor (FGF) 23.2010
- Author(s)
  Okuma T, Shinoda Y, Akiyama T, Kawano H
- Organizer
  8th Asia Pacific Musculosteletal Tumor Society Meeting.
- Place of Presentation
  Cebu, Philippines.
- Data Source
  KAKENHI-PROJECT-20591749

1. KAWANO Hirotaka (20345218)

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58. SUZUKI Akari

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
59. 伊東伸朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
60. 峯岸直子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
61. 鎌谷洋一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 4 results
62. 岡田随象

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
63. 岩崎基

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
64. 津金昌一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
65. 成松久

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
66. 岩田仲生

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
67. 池田匡志

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
68. LOW SIEWKEE

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
69. 三木大樹

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
70. 高橋隆

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
71. 橘逸勢

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
72. 山本一彦

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
73. 山内敏正

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
74. 片桐豊雅

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
75. 稲澤譲治

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
76. 鈴木顕

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
77. 醍醐弥太郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
78. 白石航也

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
79. 寺尾知可史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Akiyama Toru 秋山 達

AKIYAMA Toru 秋山 達

Research Projects

Research Products

Co-Researchers

希少がんである脊索腫における腫瘍原生並びに治療標的となるゲノム変異の探索Principal Investigator

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Review Section

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Identification of diagnostic biomarker and novel fusion genes of bone and soft tissue sarcoma

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The study of novel chondrosarcoma therapy by PEDFPrincipal Investigator

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Novel therapeutic strategy for osteosarcoma using sex hormones

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軟骨肉腫の浸潤・転移における転写因子KLF5の役割の解明

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滑膜肉腫キメラ遺伝子SYT/SSX関連タンパクの網羅的解析による分子標的薬の開発Principal Investigator

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The analysis of the mechanism of chondrocyte differentiation and apoptosisPrincipal Investigator

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[Journal Article] Trans-biobank analysis with 676,000 individuals elucidates the association of polygenic risk scores of complex traits with human lifespan2020

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[Journal Article] Large-scale genome-wide association study in a Japanese population identifies novel susceptibility lociacross different diseases2020

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[Journal Article] Chromosomal alterations among age-related haematopoietic clones in Japan2020

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[Journal Article] Genetic analysis of quantitative traits in the Japanese population links cell types to complex human diseases2018

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[Journal Article] Three-dimensional fluoroscopic navigation-assisted surgery for tumors in patients with tumor-induced osteomalacia in the bones2017

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[Journal Article] Neutrophil-to-lymphocyte ratio after pazopanib treatment predicts response in patients with advanced soft-tissue sarcoma2017

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[Journal Article] Genome-wide association study identifies 112 new loci for body mass index in the Japanese population.2017

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Akiyama Toru 秋山達

AKIYAMA Toru 秋山達

[Presentation] 骨・軟部悪性腫瘍患者における症候性静脈血栓塞栓症発症のリスクファクター　-骨軟部肉腫治療研究会(JMOG)前向き観察研究-2016