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Goto Yusuke  五島 悠介

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GOTO YUSUKE  五島 悠介

GOTO Yusuke  五島 悠介

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Researcher Number 00710576
Other IDs
Affiliation (Current) 2025: 帝京大学, 医学部, 准教授
Affiliation (based on the past Project Information) *help 2024: 帝京大学, 医学部, 講師
2021 – 2023: 千葉大学, 大学院医学研究院, 助教
2020 – 2021: 千葉大学, 大学院医学研究院, 特任助教
2015 – 2016: 千葉大学, 医学部附属病院, 医員
Review Section/Research Field
Principal Investigator
Basic Section 56030:Urology-related / 0906:Surgery related to the biological and sensory functions and related fields / Urology
Except Principal Investigator
Basic Section 53030:Respiratory medicine-related / Basic Section 57060:Surgical dentistry-related / Basic Section 56030:Urology-related
Keywords
Principal Investigator
去勢抵抗性前立腺癌 / 前立腺癌 / 機能性RNA / ムスカリン受容体 / YAP / FAK / Gタンパク共役型受容体 / G蛋白共役型受容体 / 去勢抵抗性増殖 / 神経支配 / 神経依存的増殖 / マイクロRNA … More
Except Principal Investigator
… More 肺癌 / がん微小環境 / 免疫回避 / 口腔扁平上皮癌 / YAP/TAZ / Hippo経路 / miRNA / スーパーエンハンサー / マイクロRNA / ATAC sequence / シスプラチン / 治療抵抗性 / 尿路上皮癌 Less
  • Research Projects

    (7 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (11 People)
  •  Deciphering the regulatory mechanism of cancer microenvironment induced by disruption of the Hippo pathway and novel therapeutic approach

    • Principal Investigator
      安藤 俊範
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 57060:Surgical dentistry-related
    • Research Institution
      Hiroshima University
  •  合成致死性に基づいたKRAS変異陽性肺癌におけるソトラシブ併用新規治療法の開発

    • Principal Investigator
      萩原 陽子
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53030:Respiratory medicine-related
    • Research Institution
      Kagoshima University
  •  アンドロゲン受容体標的薬と合成致死性をもつシグナル伝達分子の網羅的探索Principal Investigator

    • Principal Investigator
      五島 悠介
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Teikyo University
  •  Identification of super-enhancer and master genes involved in treatment resistance of urothelial cancer

    • Principal Investigator
      KATO MAYUKO
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Chiba University
  •  Identification of GPCR which activates FAK-YAP signaling and promotes castration-resistant growth of prostate cancerPrincipal Investigator

    • Principal Investigator
      Goto Yusuke
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Early-Career Scientists
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Chiba University
  •  Identification of mechanism of castration resistant growth of prostate cancer cells by innervationPrincipal Investigator

    • Principal Investigator
      GOTO YUSUKE
    • Project Period (FY)
      2020 – 2021
    • Research Category
      Grant-in-Aid for Research Activity Start-up
    • Review Section
      0906:Surgery related to the biological and sensory functions and related fields
    • Research Institution
      Chiba University
  •  Identification of novel CRPC therapeutics by inhibition of activated functional RNA signalingPrincipal Investigator

    • Principal Investigator
      GOTO Yusuke
    • Project Period (FY)
      2015 – 2016
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Urology
    • Research Institution
      Chiba University

All 2023 2021 2020 2017 2016 2015

All Journal Article Presentation

  • [Journal Article] Identification of Tumor-Suppressive miR-139-3p-Regulated Genes: TRIP13 as a Therapeutic Target in Lung Adenocarcinoma2023

    • Author(s)
      Hagihara Yoko、Tomioka Yuya、Suetsugu Takayuki、Shinmura Masahiro、Misono Shunsuke、Goto Yusuke、Kikkawa Naoko、Kato Mayuko、Inoue Hiromasa、Mizuno Keiko、Seki Naohiko
    • Journal Title

      Cancers

      Volume: 15 Issue: 23 Pages: 5571-5571

    • DOI

      10.3390/cancers15235571

    • URL

      https://pure.teikyo.jp/en/publications/29f65983-768e-487b-a27c-8efc44c7def8

    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-22K16196, KAKENHI-PROJECT-21K09577, KAKENHI-PROJECT-22K09679, KAKENHI-PROJECT-21K09367
  • [Journal Article] MiR-15b-5p inhibits castration-resistant growth of prostate cancer cells by targeting the muscarinic cholinergic receptor CHRM32023

    • Author(s)
      Shunichi Asai, Yusuke Goto, Kengo Tanigawa, Yuya Tomioka, Mayuko Kato, Keiko Mizuno, Shinichi Sakamoto, Naohiko Seki
    • Journal Title

      FEBS Letter

      Volume: - Issue: 8 Pages: 1164-1175

    • DOI

      10.1002/1873-3468.14598

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-21K09367, KAKENHI-PROJECT-20K09555, KAKENHI-PROJECT-21K09577, KAKENHI-PROJECT-21K16753
  • [Journal Article] EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB12021

    • Author(s)
      Ando Toshinori、Arang Nadia、Wang Zhiyong、Costea Daniela Elena、Feng Xiaodong、Goto Yusuke、Izumi Hiroki、Gilardi Mara、Ando Kazuyo、Gutkind J. Silvio
    • Journal Title

      Communications Biology

      Volume: 4 Issue: 1

    • DOI

      10.1038/s42003-021-02744-4

    • Data Source
      KAKENHI-PROJECT-20K22970
  • [Journal Article] Identification of tumor suppressive genes regulated by mir-31-5p and mir-31-3p in head and neck squamous cell carcinoma2021

    • Author(s)
      Oshima Sachi、Asai Shunichi、Seki Naohiko、Minemura Chikashi、Kinoshita Takashi、Goto Yusuke、Kikkawa Naoko、Moriya Shogo、Kasamatsu Atsushi、Hanazawa Toyoyuki、Uzawa Katsuhiro
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22 Issue: 12 Pages: 6199-6199

    • DOI

      10.3390/ijms22126199

    • URL

      https://pure.teikyo.jp/en/publications/80dd3537-f32b-4bad-a818-252a9e5b0f28

    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-19K09863, KAKENHI-PROJECT-19K18759, KAKENHI-PROJECT-20K22970
  • [Journal Article] Regulation of oncogenic targets by the tumor-suppressive mir-139 duplex (Mir-139-5p and mir-139-3p) in renal cell carcinoma2020

    • Author(s)
      Okada Reona、Goto Yusuke、Yamada Yasutaka、Kato Mayuko、Asai Shunichi、Moriya Shogo、Ichikawa Tomohiko、Seki Naohiko
    • Journal Title

      Biomedicines

      Volume: 8 Issue: 12 Pages: 1

    • DOI

      10.3390/biomedicines8120599

    • URL

      https://pure.teikyo.jp/en/publications/3732b6d5-5256-40f2-a789-91b6b4436ecc

    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-20K22970, KAKENHI-PROJECT-20H03813, KAKENHI-PROJECT-18K09338
  • [Journal Article] Aberrantly expressed microRNAs in bladder cancer and renal cell carcinoma2017

    • Author(s)
      Kurozumi A, Goto Y, Okato A, Ichikawa T, Seki N.
    • Journal Title

      J Hum Genet

      Volume: 62 Issue: 1 Pages: 49

    • DOI

      10.1038/jhg.2016.84

    • URL

      https://pure.teikyo.jp/en/publications/7905ff57-984e-4066-a590-1cb945e568eb

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-15K20071
  • [Journal Article] Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer2017

    • Author(s)
      Nohata N, Goto Y, Gutkind JS.
    • Journal Title

      J Hum Genet.

      Volume: 62 Issue: 1 Pages: 87

    • DOI

      10.1038/jhg.2016.124

    • URL

      https://pure.teikyo.jp/en/publications/524253f6-1b7a-460f-aafa-1b7f73155bb8

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Journal Article] The roles of microRNAs in the progression of castration-resistant prostate cancer.2017

    • Author(s)
      Kojima, S. Goto, Y. Naya, Y.
    • Journal Title

      J Hum Genet

      Volume: 62(1) Issue: 1 Pages: 25-31

    • DOI

      10.1038/jhg.2016.69

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-17K11160
  • [Journal Article] Regulation of E3 ubiquitin ligase-1 (WWP1) by microRNA-452 inhibits cancer cell migration and invasion in prostate cancer.2016

    • Author(s)
      Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Matsushita R, Ichikawa T, Seki N.
    • Journal Title

      Br J Cancer

      Volume: 114 Issue: 10 Pages: 1135-1144

    • DOI

      10.1038/bjc.2016.95

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071
  • [Journal Article] Regulation of UHRF1 by dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR 145-3p): class FormattedString { value: Inhibition of bladder cancer cell aggressiveness }2016

    • Author(s)
      Matsushita R, Yoshino H, Enokida H, Goto Y, Miyamoto K, Yonemori M, Inoguchi S, Nakagawa M, Seki N.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 19 Pages: 28460

    • DOI

      10.18632/oncotarget.8668

    • URL

      https://localhost/en/publications/c60002b3-2a7f-4967-bd88-b12428c875d1

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26293354, KAKENHI-PROJECT-26462416, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-16K20145
  • [Journal Article] The microRNA signature of patients with sunitinib failure: Regulation of UHRF1 pathways by microRNA-101 in renal cell carcinoma2016

    • Author(s)
      Goto Y, Kurozumi A, Nohata N, Kojima S, Matsushita R, Yoshino H, Yamazaki K, Ishida Y, Ichikawa T, Naya Y, Seki N.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 37 Pages: 59070

    • DOI

      10.18632/oncotarget.10887

    • URL

      https://pure.teikyo.jp/en/publications/c3fc2cc9-a524-4a56-b73c-fd643ab15d71

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071
  • [Journal Article] Regulation of TPD52 by antitumor microRNA-218 suppresses cancer cell migration and invasion in lung squamous cell carcinoma2016

    • Author(s)
      Kumamoto T, Seki N, Mataki H, Mizuno K, Kamikawaji K, Samukawa T, Koshizuka K, Goto Y, Inoue H.
    • Journal Title

      Int J Oncol.

      Volume: 49 Issue: 5 Pages: 1870

    • DOI

      10.3892/ijo.2016.3690

    • URL

      https://localhost/en/publications/8f8a4557-a292-4b38-a19c-8bc23a88421e

    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-15K09179
  • [Journal Article] Dual-strand tumor-suppressor microRNA-145 (miR-145-5p and miR-145-3p) coordinately targeted MTDH in lung squamous cell carcinoma2016

    • Author(s)
      Mataki H, Seki N, Mizuno K, Nohata N, Kamikawaji K, Kumamoto T, Koshizuka K, Goto Y, Inoue H.
    • Journal Title

      Oncotarget

      Volume: 7 Issue: 44 Pages: 72084

    • DOI

      10.18632/oncotarget.12290

    • URL

      https://pure.teikyo.jp/en/publications/1355d42e-148c-4eaa-bb93-df7207cf527a

    • Language
      English
    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Journal Article] Real-Time GFP Intravital Imaging of the Differences in Cellular and Angiogenic Behavior of Subcutaneous and Orthotopic Nude-Mouse Models of Human PC-3 Prostate Cancer2016

    • Author(s)
      Zhang Y, Toneri M, Ma H, Yang Z, Bouvet M, Goto Y, Seki N, Hoffman RM.
    • Journal Title

      J Cell Biochem.

      Volume: 未定 Issue: 11 Pages: 2546

    • DOI

      10.1002/jcb.25547

    • URL

      https://pure.teikyo.jp/en/publications/3dcab7bb-3455-4c6a-a653-4134160aebe9

    • Language
      English
    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Journal Article] Direct regulation of LAMP1 by tumor-suppressive microRNA-320a in prostate cancer.2016

    • Author(s)
      Okato A, Goto Y, Kurozumi A, Kato M, Kojima S, Matsushita R, Yonemori M, Miyamoto K, Ichikawa T, Seki N.
    • Journal Title

      Int J Oncol

      Volume: 49 Issue: 1 Pages: 111-122

    • DOI

      10.3892/ijo.2016.3522

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05462, KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071
  • [Journal Article] Regulation of the collagen cross-linking enzymes LOXL2 and PLOD2 by tumor-suppressive microRNA-26a/b in renal cell carcinoma2016

    • Author(s)
      Kurozumi A, Kato M, Goto Y, Matsushita R, Nishikawa R, Okato A, Fukumoto I, Ichikawa T, Seki N.
    • Journal Title

      Int J Oncol

      Volume: 48 Issue: 5 Pages: 1837

    • DOI

      10.3892/ijo.2016.3440

    • URL

      https://pure.teikyo.jp/en/publications/2e4d8748-5839-4705-8fb9-449cb38b1380

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-25293333, KAKENHI-PROJECT-15K20070, KAKENHI-PROJECT-15K20071
  • [Journal Article] Tumor-suppressive microRNA-223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer2016

    • Author(s)
      Kurozumi A, Goto Y, Matsushita R, Fukumoto I, Kato M, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
    • Journal Title

      Cancer Sci.

      Volume: 107 Issue: 1 Pages: 84

    • DOI

      10.1111/cas.12842

    • URL

      https://localhost/en/publications/74302ba8-6d76-4fa9-97e3-303411deaa0b

    • Language
      English
    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-25462469, KAKENHI-PROJECT-25293333, KAKENHI-PROJECT-15K20070
  • [Journal Article] MicroRNA-26a/b directly regulate La-related protein 1 and inhibit cancer cell invasion in prostate cancer2015

    • Author(s)
      Kato M, Goto Y, Matsushita R, Kurozumi A, Fukumoto I, Nishikawa R, Sakamoto S, Enokida H, Nakagawa M, Ichikawa T, Seki N.
    • Journal Title

      International Journal of Oncology

      Volume: 47 Issue: 2 Pages: 710

    • DOI

      10.3892/ijo.2015.3043

    • URL

      https://pure.teikyo.jp/en/publications/cadcc8b8-f9f2-4a5d-87f3-fec7805bb4a9

    • Language
      English
    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20070, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-25462469, KAKENHI-PROJECT-25293333
  • [Journal Article] MicroRNA expression signature of castration-resistant prostate cancer: the microRNA-221/222 cluster functions as a tumour suppressor and disease progression marker.2015

    • Author(s)
      Goto Y, Kojima S, Nishikawa R, Kurozumi A, Kato M, Enokida H, Matsushita R, Yamazaki K, Ishida Y, Nakagawa M, Naya Y, Ichikawa T, Seki N
    • Journal Title

      Br J Cancer

      Volume: 113 Issue: 7 Pages: 1055-1065

    • DOI

      10.1038/bjc.2015.300

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-26462430, KAKENHI-PROJECT-15K20071, KAKENHI-PROJECT-25293333
  • [Presentation] microRNA-15b-5p/ Muscarinic receptors/ YAP signaling Contributes to Castration-resistant Growth of Prostate Cancer2023

    • Author(s)
      Yusuke Goto*, Shunichi Asai, Shinichi Sakamoto, Tomokazu Sazuka, Yusuke Imamura, Naohiko Seki, Tomohiko Ichikawa, Chiba, Japan
    • Organizer
      2023年 米国泌尿器科学会年次総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-21K16753
  • [Presentation] Identification of dual tumor-suppressors (miR-222-5p/miR-222-3p) based on microRNA expression signature by deep sequencing of CRPC2016

    • Author(s)
      Yusuke Goto, Satoko Kojima, Akira Kurozumi, Mayuko Kato, Atsushi Okato, Yukio Naya, Hideki Enokida, Ryosuke Matsushita, Masayuki Nakagawa, Tomohiko Ichikawa, Naohiko Seki
    • Organizer
      American Urological Association
    • Place of Presentation
      アメリカ合衆国サンディエゴ市 サンディエゴコンベンションセンター
    • Year and Date
      2016-05-06
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Presentation] Identification of dual tumor-suppressors (miR-222-5p/miR-222-3p) based on microRNA expression signature by deep sequencing of CRPC2016

    • Author(s)
      Goto Y, Kojima S, Kurozumi A, Kato M, Okato A, Naya Y, Enokida H, Matsushita R, Nakagawa M, Ichikawa T, Seki N
    • Organizer
      AUA annual meeting 2016
    • Place of Presentation
      アメリカ合衆国サンディエゴ市
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Presentation] Regulation of UHRF1-mediated pathways by tumor-suppressive microRNA-101 in molecular targeted therapy resistant renal cell carcinoma.2016

    • Author(s)
      Goto Y, Kurozumi A, Kato M, Okato A, Kojima S, Matsushita R, Yoshino H, Enokida H, Nakagawa M, Naya Y, Ichikawa T, Seki N.
    • Organizer
      AUA annual meeting 2016
    • Place of Presentation
      アメリカ合衆国サンディエゴ市
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Presentation] 全ゲノムCRPC機能性RNA発現解析に基づくCRPC活性化分子経路の探索2016

    • Author(s)
      五島悠介、小島聡子、松下良介、黒住顕、加藤繭子、西川里佳、 坂本信一、榎田英樹、中川昌之、納谷幸男、市川智彦、関直彦
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Presentation] 去勢抵抗性前立腺癌克服に向けた全ゲノム機能性RNA解析2016

    • Author(s)
      五島悠介
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台国際センター(宮城県仙台市)
    • Invited
    • Data Source
      KAKENHI-PROJECT-15K20071
  • [Presentation] miR-221/222 cluster as a tumor suppressor based on microRNA expression signature of castration-resistant prostate cancer.2015

    • Author(s)
      Yusuke Goto, Satoko Kojima, Rika Nishikawa, Ryosuke Matsushita, Ichiro Fukumoto, Shinichi Sakamoto, Hideki Enokida, Masayuki Nakagawa, Yukio Naya, Tomohiko Ichikawa, Naohiko Seki.
    • Organizer
      第74回日本癌学会総会
    • Place of Presentation
      愛知県名古屋市 名古屋国際会議場
    • Year and Date
      2015-10-06
    • Data Source
      KAKENHI-PROJECT-15K20071
  • 1.  関 直彦 (50345013)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 2.  KATO MAYUKO (80733857)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 3.  市川 智彦 (20241953)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 2 results
  • 4.  安藤 俊範 (40754552)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 5.  加治屋 幹人 (00633041)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 6.  柳本 惣市 (10315260)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 7.  泉 大樹 (80813485)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 8.  萩原 陽子 (30992226)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 9.  水野 圭子 (50531414)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 10.  末次 隆行 (90862863)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  小島 聡子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results

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