Tajima Kazuki 田島一樹

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TAJIMA Kazuki 田島一樹

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Researcher Number	00725236
Other IDs
Affiliation (Current)	2025: 独立行政法人国立病院機構横浜医療センター(臨床研究部), 臨床研究部2, 医長
Affiliation (based on the past Project Information) *help	2017 – 2018: 横浜市立大学, 医学研究科, 客員研究員 2015 – 2016: 横浜市立大学, 附属病院, 助教
Review Section/Research Field	Principal Investigator Metabolomics Except Principal Investigator Metabolomics
Keywords	Principal Investigator 膵β細胞 / メトホルミン / 糖尿病 / アポトーシス / 高脂肪食 / 小胞体ストレス / インスリン抵抗性 / 増殖 Except Principal Investigator 糖 / 糖尿病 … More / S100A8 / 膵β細胞 / グルコキナーゼ / 膵島 Less

Effect of metformin on pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  TAJIMA Kazuki
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Fate determination of pancreatic beta cells by glucokinase activation
- Principal Investigator
  
  Terauchi Yasuo
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University
Effect of metformin on pancreatic beta cellsPrincipal Investigator
- Principal Investigator
  
  TAJIMA Kazuki
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Metabolomics
- Research Institution
  Yokohama City University

All 2018 2017 2016 2015

All Journal Article Presentation

[Journal Article] Signaling between pancreatic beta-cells and macrophages via S100 calcium-binding protein A8 exacerbates beta-cell apoptosis and islet inflammation.2018
- Author(s)
  Inoue H, Shirakawa J, Togashi Y, Tajima K, Okuyama T, Kyohara M, Tanaka Y, Saisho Y, Yamada T, Shibue K, Kulkarni RN, Terauchi Y
- Journal Title
  
  The Journal of Biological Chemistry
  
  Volume: 293 Issue: 16 Pages: 5934-5946
- DOI
  10.1074/jbc.m117.809228
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H04714, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-18K16240, KAKENHI-PROJECT-17K16152
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7(1) Issue: 1 Pages: 2345-2345
- DOI
  10.1038/s41598-017-02535-0
- NAID
  120007134459
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-17H06992
[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017
- Author(s)
  Okuyama T, Shirakawa J, Yanagisawa H, Kyohara M, Yamasaki S, Tajima K, Togashi Y, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- NAID
  120007134459
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-9062017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamazaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Sci Rep.
  
  Volume: 7 Issue: 1 Pages: 4119-4119
- DOI
  10.1038/s41598-017-04304-5
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K16152, KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-16K19542
[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.2017
- Author(s)
  Kyohara M, Shirakawa J, Okuyama T, Kimura A, Togashi Y, Tajima K, Hirano H, Terauchi Y.
- Journal Title
  
  Endocrinology
  
  Volume: 158(12) Issue: 12 Pages: 4152-4164
- DOI
  10.1210/en.2017-00339
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329, KAKENHI-PROJECT-15K19028
[Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Yamasaki S, Okuyama T, Kyohara M, Konishi H, Terauchi Y.
- Journal Title
  
  Scientific Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16H05329
[Journal Article] Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.2017
- Author(s)
  Tajima K, Shirakawa J, Okuyama T, Kyohara M, Yamazaki S, Togashi Y, Terauchi Y.
- Journal Title
  
  Am J Physiol Endocrinol Metab
  
  Volume: 313 Issue: 3 Pages: E367-E380
- DOI
  10.1152/ajpendo.00447.2016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K16152
[Journal Article] Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model.2015
- Author(s)
  Orime K, Shirakawa J, Togashi Y, Tajima K, Inoue H, Nagashima Y, Terauchi Y
- Journal Title
  
  Eur J Pharmacol
  
  Volume: 5 Pages: 22-22
- DOI
  10.1016/j.ejphar.2015.12.043
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K19521
[Journal Article] ホエイペプチド配合免疫調整流動食経口摂取が歯周炎患者における歯肉溝滲出液の炎症性サイトカインに与える影響2015
- Author(s)
  久保田健彦, 冨田尊志, 濃野要, 阿部大輔, 清水太郎, 杉田典子, 金子昇, 根津新, 川島昭浩, 坪井洋, 佐々木一, 吉江弘正
- Journal Title
  
  日本歯科保存学雑誌
  
  Volume: 58 Issue: 1 Pages: 109-116
- DOI
  10.1186/s13098-016-0138-4
- NAID
  130005068919
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K00890, KAKENHI-PROJECT-15K19521
[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017
- Author(s)
  田島一樹, 白川純, 富樫優, 寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会
- Data Source
  KAKENHI-PROJECT-17K16152
[Presentation] 膵β細胞増殖モデルマウスを用いた糖尿病研究2017
- Author(s)
  富樫優、白川純、田島一樹、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Invited
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017
- Author(s)
  田島一樹、白川純、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] OSI-906投与マウスモデルにおけるDPP-4阻害薬およびSGLT-2阻害薬の膵β細胞、肝臓、脂肪組織へ効果2017
- Author(s)
  市川大河、山崎伸悟、白川純、田島一樹、奥山朋子、山崎俊介、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017
- Author(s)
  田島一樹、白川純、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホールヴィアマーレ（横浜市西区）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-15K19521
[Presentation] ムスカリニックアゴニストによる膵β細胞増殖機構の解析2017
- Author(s)
  伊藤譲、田島一樹、富樫優、寺内康夫
- Organizer
  第31回日本糖尿病・肥満動物学会年次学術集会
- Place of Presentation
  はまぎんホール（神奈川県横浜市）
- Year and Date
  2017-02-10
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] シンポジウム Effects of metformin on pancreatic beta cells2016
- Author(s)
  田島一樹, 白川純, 富樫優、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  国立京都国際会館（京都市）
- Year and Date
  2016-05-20
- Invited
- Data Source
  KAKENHI-PROJECT-15K19521
[Presentation] S100A8を介した膵島とマクロファージの相互作用による膵島炎症惹起機構の解明2016
- Author(s)
  井上英昭、白川純、折目和基、田島一樹、富樫優、京原麻由、奥山朋子、吉田瑛子、山崎俊介、小西裕美、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  京都国際会館（京都府）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンによる膵β細胞保護作用の検討2016
- Author(s)
  田島一樹、白川純、富樫優、折目和基、寺内康夫
- Organizer
  第53回日本臨床分子医学会学術総会
- Place of Presentation
  東京国際フォーラム（東京都千代田区）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-15K19521
[Presentation] メトホルミンによる膵β細胞保護作用の検討2016
- Author(s)
  田島一樹、白川純、富樫優、折目和基、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K19521
[Presentation] A Mouse of Model of Acute Reversible Lipodystrophy with Dual Inhibition of Insulin and IGF-1 Receptors.2016
- Author(s)
  Tajima K, Shirakawa J, Togashi Y, Terauchi Y.
- Organizer
  76th American Diabetes Association (ADA) meeting
- Place of Presentation
  New Orleans，USA
- Year and Date
  2016-06-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] メトホルミンによる膵β細胞保護作用の検討2016
- Author(s)
  田島一樹、白川　純、富樫　優、折目和基、寺内康夫
- Organizer
  日本臨床分子医学会
- Place of Presentation
  東京国際フォーラム（東京都）
- Year and Date
  2016-04-15
- Data Source
  KAKENHI-PROJECT-16H05329
[Presentation] Effects of metformin on pancreatic beta cells.2016
- Author(s)
  田島一樹、白川純、富樫優、寺内康夫
- Organizer
  第59回日本糖尿病学会年次学術総会
- Place of Presentation
  国立京都国際会館（京都府京都市）
- Year and Date
  2016-05-19
- Invited
- Data Source
  KAKENHI-PROJECT-15K19521
[Presentation] メトホルミンによる膵β細胞保護作用の検討2015
- Author(s)
  田島一樹, 白川純, 富樫優、井上英昭、伊藤譲、寺内康夫
- Organizer
  第58回日本糖尿病学会年次学術総会
- Place of Presentation
  シーモールホール (山口県下関市）
- Year and Date
  2015-05-23
- Data Source
  KAKENHI-PROJECT-15K19521

1. Terauchi Yasuo (40359609)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
2. 伊藤譲 (00512980)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 富樫優 (10710444)

# of Collaborated Projects: 1 results

# of Collaborated Products: 11 results
4. 白川純 (70625532)

# of Collaborated Projects: 1 results

# of Collaborated Products: 10 results
5. YAMADA koji

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 佐々木一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 山田健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 伊藤讓

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tajima Kazuki 田島 一樹

TAJIMA Kazuki 田島 一樹

Research Projects

Research Products

Co-Researchers

Effect of metformin on pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Fate determination of pancreatic beta cells by glucokinase activation

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effect of metformin on pancreatic beta cellsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Signaling between pancreatic beta-cells and macrophages via S100 calcium-binding protein A8 exacerbates beta-cell apoptosis and islet inflammation.2018

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017

Author(s)

Journal Title

DOI

NAID

Data Source

[Journal Article] Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.2017

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Metabolic recovery of lipodystrophy, liver steatosis, and pancreatic β cell proliferation after the withdrawal of OSI-9062017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Serum quantitative proteomic analysis reveals soluble EGFR to be a marker of insulin resistance in male mice and humans.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid recovery of adipose tissue atrophy, liver steatosis, and pancreatic β cells proliferation after dual inhibition of insulin and IGF-1 receptors.2017

Author(s)

Journal Title

Data Source

[Journal Article] Effects of metformin on compensatory pancreatic β-cell hyperplasia in mice fed a high-fat diet.2017

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Lipid-lowering agents inhibit hepatic steatosis in a non-alcoholic steatohepatitis-derived hepatocellular carcinoma mouse model.2015

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ホエイペプチド配合免疫調整流動食経口摂取が歯周炎患者における歯肉溝滲出液の炎症性サイトカインに与える影響2015

Author(s)

Journal Title

DOI

NAID

Data Source

[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017

Author(s)

Organizer

Data Source

[Presentation] 膵β細胞増殖モデルマウスを用いた糖尿病研究2017

Author(s)

Organizer

Place of Presentation

Year and Date

Data Source

[Presentation] メトホルミンは、インスリン抵抗性とは独立して、膵β細胞に保護的に作用する2017

Tajima Kazuki 田島一樹

TAJIMA Kazuki 田島一樹