SHIMIZU HIROMICHI 清水寛路

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Hiromichi Shimizu 清水寛路

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Researcher Number	00733875
Other IDs
Affiliation (Current)	2025: 東京科学大学, 東京科学大学病院, 准教授
Affiliation (based on the past Project Information) *help	2023: 東京医科歯科大学, 東京医科歯科大学病院, 講師 2021 – 2022: 東京医科歯科大学, 統合研究機構, 助教 2019 – 2020: 東京医科歯科大学, 医学部附属病院, 特任助教
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator 潰瘍性大腸炎 / 潰瘍性大腸炎関連発癌 / オルガノイド / 抗IL-12/23抗体製剤 / IL-12/23 / 大腸オルガノイド / ILー12／23 / JAKファミリー分子 / JAK阻害剤 / JAK阻害薬 / クローン病

背景粘膜から見た潰瘍性大腸炎関連大腸癌のリスク解析Principal Investigator
- Principal Investigator
  
  清水寛路
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Investigation of IL-12/23 pathway in ulcerative colitisPrincipal Investigator
- Principal Investigator
  
  Shimizu Hiromichi
- Project Period (FY)
  2021 – 2022
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University
Investigation of novel JAK-STAT pathway in ulcerative colitis.Principal Investigator
- Principal Investigator
  
  Hiromichi Shimizu
- Project Period (FY)
  2019 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tokyo Medical and Dental University

All 2022 2021 2020 2019

All Journal Article Presentation

[Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022
- Author(s)
  Shuji Hibiya, Kazuo Ohtsuka, Kento Takenaka, Ami Kawamoto, Yusuke Matsuyama, Yumi Udagawa, Maiko Motobayashi, Hiromichi Shimizu, Toshimitsu Fujii, Eiko Saito, Masakazu Nagahori, Ryuichi Okamoto, Mamoru Watanabe
- Journal Title
  
  BMC Gastroenterol.
  
  Volume: 22 Issue: 1 Pages: 218-218
- DOI
  10.1186/s12876-022-02300-2
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
[Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022
- Author(s)
  Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
- Journal Title
  
  Lancet Gastroenterol Hepatol
  
  Volume: 7 Issue: 3 Pages: 230-237
- DOI
  10.1016/s2468-1253(21)00372-1
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K07977, KAKENHI-PROJECT-21K15991, KAKENHI-PROJECT-22K07978, KAKENHI-PROJECT-22H00472, KAKENHI-PROJECT-21K15918, KAKENHI-PROJECT-21K15992
[Journal Article] Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus2021
- Author(s)
  Hiromichi Shimizu, Toshimitsu Fujii, Kenji Kinoshita, Ami Kawamoto, Shuji Hibiya, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe, Ryuichi Okamoto
- Journal Title
  
  BMC Gastroenterol
  
  Volume: 21 Issue: 1 Pages: 494-494
- DOI
  10.1186/s12876-021-02043-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20K08378, KAKENHI-PROJECT-21K15991, KAKENHI-PROJECT-21K15992
[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021
- Author(s)
  Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 542 Pages: 40-47
- DOI
  10.1016/j.bbrc.2021.01.021
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis2021
- Author(s)
  Hiromichi Shimizu, Toshimitsu Fujii, Shuji Hibiya, Maiko Motobayashi, Kohei Suzuki, Kento Takenaka, Eiko Saito, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
- Journal Title
  
  Intest Res
  
  Volume: 19 Issue: 1 Pages: 115-118
- DOI
  10.5217/ir.2020.00030
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-20K08304, KAKENHI-PROJECT-20H03658, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-21K15992
[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021
- Author(s)
  Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
- Journal Title
  
  Biochemistry and Biophysics Reports
  
  Volume: 25 Pages: 100906-100906
- DOI
  10.1016/j.bbrep.2020.100906
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21597, KAKENHI-PROJECT-20K22895, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-18H02791, KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-20H03657, KAKENHI-PROJECT-18K07934, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19K23990, KAKENHI-PROJECT-17H04024, KAKENHI-PROJECT-20K22920, KAKENHI-PROJECT-17K19675, KAKENHI-PROJECT-21H02895, KAKENHI-PROJECT-21K15992
[Journal Article] 重症度評価と粘膜治癒の意義2020
- Author(s)
  大塚和朗、竹中健人、藤井俊光、齊藤詠子、本林麻衣子、清水寛路、日比谷秀爾、長堀正和、土屋輝一郎、渡辺　守
- Journal Title
  
  消化器内視鏡
  
  Volume: 32
- Open Access
- Data Source
  KAKENHI-PROJECT-19K17484
[Journal Article] Stem cell-based therapy for inflammatory bowel disease.2019
- Author(s)
  Hiromichi Shimizu, Kohei Suzuki, Mamoru Watanabe, Ryuichi Okamoto
- Journal Title
  
  Intest Res
  
  Volume: 17 Issue: 3 Pages: 311-316
- DOI
  10.5217/ir.2019.00043
- Open Access
- Data Source
  KAKENHI-PROJECT-19H03634, KAKENHI-PROJECT-19K17484
[Journal Article] 【炎症性腸疾患診療のupdate-診断・治療の最新知見】炎症性腸疾患の内科治療　粘膜再生治療法2019
- Author(s)
  清水寛路、鈴木康平、岡本隆一、渡辺　守
- Journal Title
  
  臨床消化器内科
  
  Volume: 34 Pages: 894-898
- Open Access
- Data Source
  KAKENHI-PROJECT-19K17484
[Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019
- Author(s)
  Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
- Journal Title
  
  Clinical Gastroenterology and Hepatology
  
  Volume: inpress Issue: 7 Pages: 1545-1552
- DOI
  10.1016/j.cgh.2019.08.024
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07902, KAKENHI-PROJECT-19K08364, KAKENHI-PROJECT-19K08438, KAKENHI-PROJECT-17K09370, KAKENHI-PROJECT-17K09372, KAKENHI-PROJECT-19K17484, KAKENHI-PROJECT-19H01050, KAKENHI-PROJECT-19K17425
[Presentation] 難治性潰瘍性大腸炎治療におけるトファシチニブの長期使用成績2022
- Author(s)
  青沼　優子、清水　寛路、河本　亜美、日比谷　秀爾、竹中　健人、藤井　俊光、齊藤　詠子、長堀　正和、大塚　和朗、岡本　隆一
- Organizer
  第13回日本炎症性腸疾患学会
- Data Source
  KAKENHI-PROJECT-21K15992
[Presentation] 当院における潰瘍性大腸炎に対するフィルゴチニブの治療成績2022
- Author(s)
  清水寛路、青沼優子、河本亜美、日比谷秀爾、竹中健人、藤井俊光、齊藤詠子、長堀正和、大塚和朗、岡本隆一
- Organizer
  第13回日本炎症性腸疾患学会
- Data Source
  KAKENHI-PROJECT-21K15992
[Presentation] 難治性潰瘍性大腸炎におけるトファシチニブの治療成績2020
- Author(s)
  清水寛路、藤井俊光、日比谷秀爾、本林麻衣子、竹中健人、齊藤詠子、長堀正和、大塚和朗、渡辺　守
- Organizer
  第16回日本消化管学会総会学術集会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] realworldにおける潰瘍性大腸炎に対するウステキヌマブの治療成績2020
- Author(s)
  清水　寛路、宇田川　祐実、河本　亜美、日比谷　秀爾、竹中　健人、藤井　俊光、齊藤　詠子、長堀　正和、大塚　和朗、岡本　隆一
- Organizer
  第11回日本炎症性腸疾患学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] Intolerance to 5-aminosalicylate is a risk of poor prognosis in Ulcerative colitis patients.2020
- Author(s)
  Toshimitsu Fujii, Shuji Hibiya, Chiaki Maeyashiki, Eiko Saito, Kento Takenaka, Maiko Motobayashi, Hiromichi Shimizu, Masakazu Nagahori, Kazuo Ohtsuka, Masayuki Kurosaki, Tsunehito Yauchi, Mamoru Watanabe
- Organizer
  ECCO2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 潰瘍性大腸炎治療における 5-ASA 不耐の予後への影響の検討2019
- Author(s)
  日比谷秀爾、藤井俊光、齊藤詠子、本林麻衣子、竹中健人、清水寛路、長堀正和、大塚和朗、黒崎雅之、矢内常人、泉並木、渡辺守
- Organizer
  第10回日本炎症性腸疾患学会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 【The 6th JSGE International Topic Conference　Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）2019
- Author(s)
  Ryuichi Okamoto, Mao Kawai, Minami Hama, Sayaka Nagata, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Sho Anzai, Junichi Takahashi, Reiko Kuno, Sayaka Takeoka, Yui Hiraguri, Shiro Yui, Mamoru Watanabe
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 【シンポジウム6：難治性潰瘍性大腸炎の治療戦略における外科と内科のコラボレーション】当院における難治性潰瘍性大腸炎における内科治療とその限界，手術症例を含めた検討2019
- Author(s)
  清水寛路、齊藤詠子、渡辺守
- Organizer
  第105回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 【消化器疾患と再生医療】炎症性腸疾患に対する再生医療の開発2019
- Author(s)
  岡本隆一、清水寛路、渡辺　守
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] Small bowel endoscopic healing of Crohn’s disease treated with anti-TNF antibodies2019
- Author(s)
  Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Kohei Suzuki, Hiromichi Shimizu, Maiko Motobayashi, Shuji Hibiya, Eiko Saito, Masakazu Nagahori, Mamoru Watanabe
- Organizer
  AOCC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 【ワークショップ1：IBDに対する新規治療薬の位置付け】トファシチニブによる潰瘍性大腸炎治療における実臨床の成績2019
- Author(s)
  清水寛路、藤井俊光、本林麻衣子、日比谷秀爾、竹中健人、齊藤詠子、長堀正和、大塚和朗、渡辺守
- Organizer
  第10回日本炎症性腸疾患学会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] The clinical efficacy of ustekinumab (UST) in patients with Crohn’s disease (CD)2019
- Author(s)
  Eiko Saito, Kohei Suzuki, Shuuji Hibiya, Maiko Motobayashi, Kento Takenaka, Nobukatsu Horita, Hiromichi Shimizu, Michio Onizawa, Toshimitsu Fujii, Masakazu Nagahori, Kazuo Ohtsuka, Mamoru Watanabe
- Organizer
  AOCC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 潰瘍性大腸炎における5ASA不耐は予後不良因子となる2019
- Author(s)
  藤井俊光、日比谷秀爾、齊藤詠子、竹中健人、清水寛路、長堀正和、大塚和朗、黒崎雅之、矢内常人、泉並木、渡辺守
- Organizer
  JDDW2019
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 患者由来腸上皮オルガノイドを用いたイソフラボン類による腸上皮機能調節機構の解析2019
- Author(s)
  川井麻央、河本亜美、永田紗矢香、安斎　翔、高橋純一、久野玲子、平栗優衣、鈴木康平、清水寛路、油井史郎、岡本隆一、渡辺　守
- Organizer
  第56回日本消化器免疫学会総会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] 潰瘍性大腸炎に対するベドリズマブのreal world experience2019
- Author(s)
  藤井俊光、清水寛路、本林麻衣子、日比谷秀爾、竹中健人、齊藤詠子、長堀正和、大塚和朗、渡辺守
- Organizer
  第10回日本炎症性腸疾患学会
- Data Source
  KAKENHI-PROJECT-19K17484
[Presentation] Functional analysis of isoflavones using patient-derived intestinal organoids2019
- Author(s)
  Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M
- Organizer
  AOCC2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17484

1. 岡本隆一 (50451935)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
2. 長堀正和

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
3. 油井史郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
4. 渡辺守

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
5. 齊藤詠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 3 results
6. 大塚和朗

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
7. 竹中健人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SHIMIZU HIROMICHI 清水 寛路

Hiromichi Shimizu 清水 寛路

Research Projects

Research Products

Co-Researchers

背景粘膜から見た潰瘍性大腸炎関連大腸癌のリスク解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of IL-12/23 pathway in ulcerative colitisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of novel JAK-STAT pathway in ulcerative colitis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mucosal healing of small intestinal stricture is associated with improved prognosis post-dilation in Crohn's disease2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Intravenous tacrolimus is a superior induction therapy for acute severe ulcerative colitis compared to oral tacrolimus2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Rapid prediction of 1-year efficacy of tofacitinib for treating refractory ulcerative colitis2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 重症度評価と粘膜治癒の意義2020

Author(s)

Journal Title

Data Source

[Journal Article] Stem cell-based therapy for inflammatory bowel disease.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 【炎症性腸疾患診療のupdate-診断・治療の最新知見】炎症性腸疾患の内科治療 粘膜再生治療法2019

Author(s)

Journal Title

Data Source

[Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019

Author(s)

Journal Title

DOI

Data Source

[Presentation] 難治性潰瘍性大腸炎治療におけるトファシチニブの長期使用成績2022

Author(s)

Organizer

Data Source

[Presentation] 当院における潰瘍性大腸炎に対するフィルゴチニブの治療成績2022

Author(s)

Organizer

Data Source

[Presentation] 難治性潰瘍性大腸炎におけるトファシチニブの治療成績2020

SHIMIZU HIROMICHI 清水寛路

Hiromichi Shimizu 清水寛路

[Journal Article] 【炎症性腸疾患診療のupdate-診断・治療の最新知見】炎症性腸疾患の内科治療　粘膜再生治療法2019

[Presentation] 【The 6th JSGE International Topic Conference　Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract（role of gut microbiome and diet）2019