Takashashi Kenji 高橋賢治

… Alternative Names

Takahashi Kenji 高橋賢治

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Researcher Number	00736332
Other IDs	https://orcid.org/0000-0002-6166-6848
Affiliation (Current)	2025: 旭川医科大学, 医学部, 講師
Affiliation (based on the past Project Information) *help	2024: 旭川医科大学, 医学部, 講師 2018 – 2023: 旭川医科大学, 大学病院, 助教 2016 – 2017: 旭川医科大学, 大学病院, 医員 2015: 旭川医科大学, 大学病院, その他
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related / Gastroenterology Except Principal Investigator Basic Section 53010:Gastroenterology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Medium-sized Section 53:Organ-based internal medicine and related fields / Gastroenterology / Metabolomics
Keywords	Principal Investigator 膵癌 / 細胞外小胞 / リキッドバイオプシー / ncRNA / EMT / extracellular vesicles / long non-coding RNA / 上皮間葉形質転換 / 長鎖機能性RNA / 遺伝子変異 … More / 分子サブタイプ / エクソソーム / 長鎖ノンコーディングRNA / lncRNA / バイオマーカー / 上皮間葉形質転換(EMT) / 細胞外小胞(EV) / liquid biopsy / 体液診断 / Extracellular vesicle / Long non-coding RNA / microRNA … More Except Principal Investigator 早期診断 / 膵癌 / バイオマーカー / リキッドバイオプシー / IPMN / 前駆病変 / 肝細胞癌 / マルチレイヤ―核酸解析 / ノンコーディングRNA(ncRNA) / マルチレイヤー核酸解析 / ノンコーディングRNA / 自己免疫性膵炎 / 遊離RNA / ゲノム編集 / ドライバー変異 / 遊離核酸 / RNA結合蛋白 / circular RNA / 炎症性腸疾患 / 分子マーカー / 浸潤 / 分子サブタイプ / cell-of-origin / クローン進化 / チロシンキナーゼ阻害薬 / 微小環境 / microRNA / 耐性 / エキソソーム / 癌幹細胞 / 結節性病変電顕所見 / in vivo imaging / 腎症バイオマーカー / 低酸素 / 酸化ストレス / HIF-1 / 糖尿病腎症 / メタロチオネイン3 Less

Early Diagnosis of Pancreatic Cancer Based on the Mechanism of Development of Precancerous Lesions and the Emergence of Invasive Buds during Carcinogenesis
- Principal Investigator
  
  水上裕輔
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
膵癌分子サブタイプに関わるncRNAの探索と分子診断および創薬への応用Principal Investigator
- Principal Investigator
  
  高橋賢治
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
炎症性腸疾患におけるCircular RNA-RNA結合蛋白相互作用の解析
- Principal Investigator
  
  安藤勝祥
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Liquid Biopsy using Multi-Nucleic Acid for the early diagnosis of PDAC
- Principal Investigator
  
  小野裕介
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Center for Clinical and Biomedical Research, Sapporo Higashi Tokushukai Hospital
血漿遊離核酸マルチレイヤー解析の自己免疫性膵炎診断・活動性評価への応用
- Principal Investigator
  
  岩本英孝
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
Strategy for an early diagnosis by modeling the developmental and evolutionary paths of human pancreatic cancer
- Principal Investigator
  
  水上裕輔
- Project Period (FY)
  2022 – 2025
- Research Category
  
  Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
- Review Section
  
  Medium-sized Section 53:Organ-based internal medicine and related fields
- Research Institution
  Asahikawa Medical College
The clinical applications of long non-coding RNA and extracellular vesicles to diagnosis and therapy for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI Kenji
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Asahikawa Medical College
肝癌のチロシンキナーゼ阻害薬に対する耐性獲得機序の解明と耐性克服薬の探索
- Principal Investigator
  
  小暮高之
- Project Period (FY)
  2020 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  Tohoku Medical and Pharmaceutical University
Analysis of the mechanism of tumor microenvironment modulation through exosomes in hepatocellular cancer stem cells
- Principal Investigator
  
  Kogure Takayuki
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Tohoku Medical and Pharmaceutical University
  Tohoku University
Analysis of EV encapsulated long non-coding RNA as the liquid biopsy for pancreatic cancerPrincipal Investigator
- Principal Investigator
  
  TAKAHASHI KENJI
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College
Metallothionein 3: A New Player in Diabetic Nephropathy
- Principal Investigator
  
  TAKIYAMA YUMI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Asahikawa Medical College
EV mediated transfer of long non-coding RNA in pancreatic cancer developmentPrincipal Investigator
- Principal Investigator
  
  Takahashi Kenji
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Gastroenterology
- Research Institution
  Asahikawa Medical College

All 2024 2023 2022 2021 2020 2019 2018 2017 2016 2015

All Journal Article Presentation Book Patent

[Book] 胆と膵 Vol.44No.7(2023-7)2023
- Author(s)
  小野裕介、高橋賢治、水上裕輔
- Publisher
  医学図書出版
- ISBN
  9784865175400
- Data Source
  KAKENHI-PROJECT-21K07954
[Book] 日本臨牀　増刊号　膵癌・胆道癌2023　上　膵癌編2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔
- Total Pages
  13
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-21K07954
[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔．
- Total Pages
  99
- Publisher
  日本臨牀社
- Data Source
  KAKENHI-PROJECT-22KK0125
[Book] 胆と膵2022
- Author(s)
  高橋賢治, 大森優子, 小野裕介, 古川　徹, 水上裕輔
- Total Pages
  10
- Publisher
  医学図書出版
- Data Source
  KAKENHI-PROJECT-21K07954
[Journal Article] Liquid Biopsy for Pancreatic Cancer by Serum Extracellular Vesicle-Encapsulated Long Noncoding RNA HEVEPA.2024
- Author(s)
  Takahashi K, Inuzuka T, Shimizu Y, Sawamoto K, Taniue K, Ono Y, Asai F, Koyama K, Sato H, Kawabata H, Iwamoto H, Yamakita K, Kitano Y, Teramoto T, Fujiya M, Fujii S, Mizukami Y, Okumura T.
- Journal Title
  
  Pancreas.
  
  Volume: - Issue: 5 Pages: 395-404
- DOI
  10.1097/mpa.0000000000002315
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-23K07389, KAKENHI-PROJECT-21K07954
[Journal Article] New gel immersion endoscopic ultrasonography technique for accurate periampullary evaluation.2024
- Author(s)
  Sato H, Kawabata H, Iwamoto H, Okada T, Fujibayashi S, Takahashi K, Kitano Y, Goto T, Mizukami Y, Okumura T, Fujiya M.
- Journal Title
  
  Surg Endosc.
  
  Volume: 38 (4) Issue: 4 Pages: 2297-2394
- DOI
  10.1007/s00464-024-10762-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-23K07389, KAKENHI-PROJECT-21K07954
[Journal Article] Genomic insights into familial adenomatous polyposis: unraveling a rare case with whole APC gene deletion and intellectual disability2024
- Author(s)
  Tanabe Hiroki、Ijiri Masami、Takahashi Kenji、Sasagawa Honoka、Kamanaka Tomomi、Kuroda Shohei、Sato Hiroki、Sarashina Takeo、Mizukami Yusuke、Makita Yoshio、Okumura Toshikatsu
- Journal Title
  
  Human Genome Variation
  
  Volume: 11 Issue: 1 Pages: 13-13
- DOI
  10.1038/s41439-024-00270-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-21K07954
[Journal Article] Local recurrence after successful endoscopic submucosal dissection for rectal mucinous mucosal adenocarcinoma: A case report2023
- Author(s)
  Murakami Yuki、Tanabe Hiroki、Ono Yusuke、Sugiyama Yuya、Kobayashi Yu、Kunogi Takehito、Sasaki Takahiro、Takahashi Keitaro、Ando Katsuyoshi、Ueno Nobuhiro、Kashima Shin、Yuzawa Sayaka、Moriichi Kentaro、Mizukami Yusuke、Fujiya Mikihiro、Okumura Toshikatsu
- Journal Title
  
  World Journal of Gastrointestinal Oncology
  
  Volume: 15 Issue: 1 Pages: 186-194
- DOI
  10.4251/wjgo.v15.i1.186
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-19K17419, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759
[Journal Article] Multiplex Digital PCR Assay to Detect Multiple KRAS and GNAS Mutations Associated with Pancreatic Carcinogenesis from Minimal Specimen Amounts2023
- Author(s)
  Maeda Chiho、Ono Yusuke、Hayashi Akihiro、Takahashi Kenji、Taniue Kenzui、Kakisaka Rika、Mori Miyuki、Ishii Takahiro、Sato Hiroki、Okada Tetsuhiro、Kawabata Hidemasa、Goto Takuma、Tamamura Nobue、Omori Yuko、Takahashi Kuniyuki、Katanuma Akio、Karasaki Hidenori、Liss Andrew Scott、Mizukami Yusuke
- Journal Title
  
  The Journal of Molecular Diagnostics
  
  Volume: 23 Issue: 6 Pages: 1525-1578
- DOI
  10.1016/j.jmoldx.2023.02.007
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-21K20855, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-23K06759, KAKENHI-PROJECT-22K16010, KAKENHI-PROJECT-21H02758
[Journal Article] Current status of molecular diagnostic approaches using liquid biopsy2023
- Author(s)
  Takahashi Kenji、Takeda Yohei、Ono Yusuke、Isomoto Hajime、Mizukami Yusuke
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 58 Issue: 9 Pages: 834-847
- DOI
  10.1007/s00535-023-02024-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-21K07954
[Journal Article] Genomic medicine for the early detection of pancreatic cancer2022
- Author(s)
  SATO Hiroki、TAKAHASHI Kenji、MIZUKAMI Yusuke
- Journal Title
  
  Suizo
  
  Volume: 37 Issue: 1 Pages: 29-39
- DOI
  10.2958/suizo.37.29
- NAID
  130008164821
- ISSN
  0913-0071, 1881-2805
- Year and Date
  2022-02-28
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-21K07954
[Journal Article] Mutant GNAS limits tumor aggressiveness in established pancreatic cancer via antagonizing the KRAS-pathway2022
- Author(s)
  Kawabata Hidemasa、Ono Yusuke、Tamamura Nobue、Oyama Kyohei、Ueda Jun、Sato Hiroki、Takahashi Kenji、Taniue Kenzui、Okada Tetsuhiro、Fujibayashi Syugo、Hayashi Akihiro、ほか
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 57 Issue: 3 Pages: 208-220
- DOI
  10.1007/s00535-021-01846-4
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K16947, KAKENHI-PUBLICLY-20H04896, KAKENHI-PROJECT-19K07261, KAKENHI-PROJECT-19K16484, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-20K17009, KAKENHI-PROJECT-21KK0283, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-19H03448, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-20K09070, KAKENHI-PROJECT-19K17480, KAKENHI-PROJECT-19K06452, KAKENHI-PROJECT-21H02758
[Journal Article] ゲノム解析による膵癌の早期診断．2022
- Author(s)
  佐藤裕基、高橋賢治、水上裕輔．
- Journal Title
  
  膵臓
  
  Volume: 37 Pages: 29-39
- NAID
  130008164821
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22KK0125
[Journal Article] IPMN の悪性度評価とliquid biopsy．2022
- Author(s)
  高橋賢治、大森優子、小野裕介、古川　徹、水上裕輔．
- Journal Title
  
  胆と膵
  
  Volume: 43 Pages: 99-99
- Data Source
  KAKENHI-PROJECT-22KK0125
[Journal Article] RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival2022
- Author(s)
  Taniue Kenzui、Tanu Tanzina、Shimoura Yuki、Mitsutomi Shuhei、Han Han、Kakisaka Rika、Ono Yusuke、Tamamura Nobue、Takahashi Kenji、Wada Youichiro、Mizukami Yusuke、Akimitsu Nobuyoshi
- Journal Title
  
  International Journal of Molecular Sciences
  
  Volume: 23 Issue: 1 Pages: 496-496
- DOI
  10.3390/ijms23010496
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18KT0016, KAKENHI-PUBLICLY-20H04838, KAKENHI-PROJECT-21K19402, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-20KK0174, KAKENHI-PROJECT-22KK0125, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-21H02758
[Journal Article] Long Non-Coding RNAs in Epithelial-Mesenchymal Transition of Pancreatic Cancer2021
- Author(s)
  Takahashi Kenji、Taniue Kenzui、Ono Yusuke、Fujiya Mikihiro、Mizukami Yusuke、Okumura Toshikatsu
- Journal Title
  
  Frontiers in Molecular Biosciences
  
  Volume: 8 Pages: 717890-717890
- DOI
  10.3389/fmolb.2021.717890
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K07671, KAKENHI-PROJECT-21K07954, KAKENHI-PROJECT-21K19402, KAKENHI-PROJECT-20H03655, KAKENHI-PROJECT-21H02758
[Patent] 膵癌のバイオマーカー2020
- Inventor(s)
  高橋賢治、犬塚達俊
- Industrial Property Rights Holder
  高橋賢治、犬塚達俊
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2020-010122
- Filing Date
  2020
- Data Source
  KAKENHI-PROJECT-17K09450
[Presentation] 専門医セミナー「膵胆道癌診療最新Topics」講演1: 膵胆道癌の個別化治療とがん遺伝子診療2024
- Author(s)
  高橋賢治
- Organizer
  第134回日本消化器病学会北海道支部例会
- Invited
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Crucial knowledge for early detection and prevention of pancreatic cancer：Genomic alterations and subtypes in precancerous lesions2024
- Author(s)
  Kenji Takahashi, Yusuke Mizukami
- Organizer
  The 13th International Forum of The Japanese Society of Gastroenterology
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] IPMN関連膵癌におけるGNAS遺伝子の病態解明からみた治療戦略2023
- Author(s)
  河端秀賢、高橋賢治、梶浦麻未、小杉英史、佐藤裕基、岡田哲弘、岩本英孝、北野陽平、藤谷幹浩、奥村利勝、水上裕輔
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Circulating extracellular vesicle-encapsulated long non-coding RNAs obtained via liquid biopsy are potential biomarkers for pancreatic ductal adenocarcinoma2023
- Author(s)
  Kenji Takahashi, Tatsutoshi Inuzuka, Fumi Asai, Kazuya Koyama, Yusuke Ono, Kenzui Taniue, Mami Kajiura, Hiroki Sato, Tetsuhiro Okada,Hidemasa Kawabata, Hidetaka Iwamoto, Yohei Kitano, Takashi Teramoto, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura
- Organizer
  United European Gastroenterology Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] High-sensitive liquid biopsy using pancreatic juice/duodenal fluid containing tumor-derived DNA to capture genetic mutations by molecular barcode sequencing2023
- Author(s)
  Ono Y, Takahashi K, Maeda C, Hayashi A, Kawabata H, Okada T, Sato H, Saito A, Kawamoto T, Takahashi K, Kimura K, Iwano H, Yanagawa N, Suzuki M, Mori M, Karasaki H, Mizukami Y
- Organizer
  31st UEG week 2023; Abstract Session "New insights into pancreatic diseases: From inflammation to cancer"
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K06759
[Presentation] 膵液由来遊離核酸を用いた膵癌liquid biopsyの取り組みについて2023
- Author(s)
  高橋賢治、水上裕輔、奥村利勝
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔
- Organizer
  第109回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 細胞外小胞内包型ノンコーディングRNAの膵癌リキッドバイオプシー標的としての有用性2023
- Author(s)
  小山一也、高橋賢治、梶浦麻未、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第31回若手膵臓研究会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] High-sensitive liquid biopsy using pancreatic juice/duodenal fluid containing tumor-derived DNA to capture genetic mutations by molecular barcode sequencing.2023
- Author(s)
  Yusuke Ono, Kenji Takahashi, Chiho Maeda, Akihiro Hayashi, Hidemasa Kawabata, Tetsuhiro Okada, Hiroki Sato, Atsushi Saito, Toru Kawamoto, Kuniyuki Takahashi, Keisuke Kimura, Hirotoshi Iwano, Nobuyuki Yanagawa, Mayumi Suzuki, Miyuki Mori, Hidenori Karasaki, Yusuke Mizukami.
- Organizer
  UEGW 112th Annual Meeting. Abstract session.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] IPMN関連膵癌におけるGNAS遺伝子の病態解明からみた治療戦略2023
- Author(s)
  河端秀賢、高橋賢治、梶浦麻未、小杉英史、佐藤裕基、岡田哲弘、岩本英孝、北野陽平、藤谷幹浩、奥村利勝、水上裕
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] 細胞外小胞EV内RNAに着目した膵癌バイオマーカー探索2023
- Author(s)
  高橋賢治、梶浦麻未、小杉英史、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、奥村利勝、水上裕輔
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Tumor suppressor miRNA-665 based serum biomarker for detecting pancreatobiliary cancer2023
- Author(s)
  Shuichi Mitsunaga, Makoto Ueno, Masahiro Tsuda, Takamichi Kuwahara, Yukiko Takayama, Keiji Hanada, Hitoshi Yoshida, Kenji Takahashi, Kohei Nakata, Masafumi Ikeda, Satoshi Kobayshi, Ikuya Miki, Kasuo Hara, Ryota Higuchi, Akinori Shimizu, Tomohiro Nomoto, Hidetaka Iwamoto, Masafumi Nakamura, Atsushi Ochiai
- Organizer
  AACR Annual Meeting 2023
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Tumor suppressor miRNA-665 based serum biomarker for detecting pancreatobiliary cancer2023
- Author(s)
  Shuichi Mitsunaga, Makoto Ueno, Masahiro Tsuda, Takamichi Kuwahara, Yukiko Takayama, Keiji Hanada, Hitoshi Yoshida, Kenji Takahashi, Kohei Nakata, Masafumi Ikeda, Satoshi Kobayshi, Ikuya Miki, Kasuo Hara, Ryota Higuchi, Akinori Shimizu, Tomohiro Nomoto, Hidetaka Iwamoto, Masafumi Nakamura, Atsushi Ochiai
- Organizer
  AACR Annual Meeting 2023
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] Circulating extracellular vesicle-encapsulated long non-coding RNAs obtained via liquid biopsy are potential biomarkers for pancreatic ductal adenocarcinoma2023
- Author(s)
  Kenji Takahashi, Tatsutoshi Inuzuka, Fumi Asai, Kazuya Koyama, Yusuke Ono, Kenzui Taniue, Mami Kajiura, Hiroki Sato, Tetsuhiro Okada,Hidemasa Kawabata, Hidetaka Iwamoto, Yohei Kitano, Takashi Teramoto, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura
- Organizer
  United European Gastroenterology Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] 細胞外小胞内包型ノンコーディングRNAの膵癌リキッドバイオプシー標的としての有用性2023
- Author(s)
  小山一也、高橋賢治、梶浦麻未、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第31回若手膵臓研究会
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] 細胞外小胞EVsとノンコーディングRNAを用いた新規膵癌リキッドバイオプシー体系の構築2023
- Author(s)
  高橋賢治、小山一也、梶浦麻未、佐藤裕基、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第8回 Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 循環EVs中miR-425による膵癌進展制御機構およびリキッドバイオプシー標的としての有用性の検討2023
- Author(s)
  小山一也、高橋賢治、梶浦麻未、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第31回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] DIC合併重症急性膵炎の臨床的アウトカムに関する検討2023
- Author(s)
  岩本英孝、高橋賢治、梶浦麻未、小杉英史、佐藤裕基、岡田哲弘、河端秀賢、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] DIC合併重症急性膵炎の臨床的アウトカムに関する検討2023
- Author(s)
  岩本英孝、高橋賢治、梶浦麻未、小杉英史、佐藤裕基、岡田哲弘、河端秀賢、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] 細胞外小胞EVsとノンコーディングRNAを用いた新規膵癌リキッドバイオプシー体系の構築2023
- Author(s)
  高橋賢治、小山一也、梶浦麻未、佐藤裕基、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第8回 Gastro-PLUS
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] Identification of microRNAs involved in resistance of lenvatinib under hypoxia in hepatocellular carcinoma2023
- Author(s)
  Mari Satoh, Takayuki Kogure, Takehito Ito, Masanori Takahashi, Kouji Okada, Kensuke Usui, Kennichi Satoh
- Organizer
  The Liver Meeting 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K08293
[Presentation] 膵液由来遊離核酸を用いた膵癌liquid biopsyの取り組みについて.2023
- Author(s)
  高橋賢治、水上裕輔、奥村利勝.
- Organizer
  第109回日本消化器病学会総会. ワークショップ2：消化器診療とliquid biopsy.
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] IPMN関連膵癌における変異型GNASによる腫瘍悪性度の制御.2023
- Author(s)
  河端秀賢、高橋賢治、水上裕輔.
- Organizer
  第109回日本消化器病学会総会. シンポジウム 6:消化器がん分子標的・免疫療法の新展開.
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] 循環EVs中miR-425による膵癌進展制御機構およびリキッドバイオプシー標的としての有用性の検討2023
- Author(s)
  小山一也、高橋賢治、梶浦麻未、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第31回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] 細胞外小胞EV内RNAに着目した膵癌バイオマーカー探索2023
- Author(s)
  高橋賢治、梶浦麻未、小杉英史、岡田哲弘、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、奥村利勝、水上裕輔
- Organizer
  第54回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-23K07389
[Presentation] Circulating extracellular vesicle-encapsulated long non-coding RNAs obtained via liquid biopsy are potential biomarkers for pancreatic ductal adenocarcinoma.2023
- Author(s)
  Kenji Takahashi, Tatsutosi Inuzuka, Fumi Asai, Kazuya Koyama, Mami Kajiura, Hiroki Sato, Tetsuhiro Okada,Hidemasa Kawabata, Hidetaka Iwamoto, Yohei Kitano, Mikihiro Fujiya, Yusuke Mizukami, Toshikatsu Okumura.
- Organizer
  UEGW 112th Annual Meeting. Moderated Posters.
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Serum miRNA signature for detecting pancreatobiliary cancer2023
- Author(s)
  Tomomi Hamaguchi, Shuichi Mitsunaga, Makoto Ueno, Masafumi Ikeda, Seiya Miki, Takamichi Kuwahara, Yukiko Takayama, Keiji Hanada, Hitoshi Yoshida, Kenji Takahashi, Kohei Nakata, Hideaki Iwama, Satoko Takizawa
- Organizer
  第82回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] GNAS変異はKRAS経路に拮抗することにより、膵癌の悪性度を抑える.2022
- Author(s)
  Hidemasa Kawabata, Yusuke Ono, Kenji Takahashi, Kenzui Taniue, Hidenori Karasaki, Yusuke Mizukami.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Molecular barcode sequencing using duodenal fluid for profiling genomic alterations in pancreatic neoplasms.2022
- Author(s)
  Ono Y, Takahashi K, Hayashi A, Kawamoto T, Okada T, Kimura K, Yanagawa N, Iwano H, Takahashi K, Karasaki H, Mizukami Y．
- Organizer
  第26回国際膵臓学会　Panel Discussion 4 Quest for early diagnosis of pancreatic cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] High-sensitive mutation detection in liquid biopsy with duodenal fluid captures genetic mutations associated with pancreatic carcinogenesis.2022
- Author(s)
  Yusuke Ono , Chiho Maeda, Kenji Takahashi, Hidenori Karasaki, Yusuke Mizukami
- Organizer
  AACR Special Conference on Pancreatic Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Development of the diagnostic method for pancreatic cancer using novel isolation technology of extracellular vesicles2022
- Author(s)
  Yuta Shimizu, Kenji Takahashi, Fumi Asai, Tatsutoshi Inuzuka
- Organizer
  AACR Special Conference on Precision Prevention, Early Detection, and Interception of Cancer
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] Molecular barcode sequencing using duodenal fluid for profiling genomic alterations in pancreatic neoplasms2022
- Author(s)
  Yusuke Ono, Kenji Takahashi, Hidenori Karasaki, Yusuke Mizukami, Akihiro Hayashi, Toru Kawamoto, Tetsuhiro Okada, Keisuke Kimura, Nobuyuki Yanagawa, Hirotoshi Iwano, Kuniyuki Takahashi, Yusuke Mizukami
- Organizer
  The 26th International Association of Pancreatology (IAP) & The 53rd Annual Meeting of Japan Pancreats Society (JPS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 十二指腸液由来遊離核酸を用いた膵癌リキッドバイオプシーの有用性2022
- Author(s)
  高橋賢治、林　明宏、水上裕輔
- Organizer
  第108回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 膵癌微小環境における細胞外小胞EVs の役割について2022
- Author(s)
  小山一也、高橋賢治、佐藤裕基、藤林周吾、河端秀賢、岩本英孝、北野陽平、藤谷幹浩、水上裕輔、奥村利勝
- Organizer
  第30 回若手膵臓研究会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 十二指腸液由来遊離核酸を用いた膵癌リキッドバイオプシーの有用性.2022
- Author(s)
  高橋賢治、林明宏、水上裕輔.
- Organizer
  第108回日本消化器病学会総会.　ワークショップ 16:胆膵疾患の遺伝子解析による病態解明・臨床展開
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] The application of EV RNA panel as liquid biopsy for pancreatic ductal adenocarcinoma2022
- Author(s)
  Kenji Takahashi, Hiroki Sato, Shugo Fujibayashi, Akihiro Hayashi, Hidemasa Kawabata, Hidetaka Iwamoto, Takuma Goto, Yohei Kitano, Yusuke Mizukami, Toshikatsu Okumura
- Organizer
  The 26th International Association of Pancreatology (IAP) & The 53rd Annual Meeting of Japan Pancreats Society (JPS) 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] High-sensitive mutation detection in liquid biopsy with duodenal fluid captures genetic mutations associated with pancreatic carcinogenesis.2022
- Author(s)
  Ono Y, Maeda C, Takahashi K, Karasaki H, Mizukami Y.
- Organizer
  AACR Special Conference on Pancreatic Cancer (Plenary session)
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] The application of EV RNA panel as liquid biopsy for pancreatic ductal adenocarcinoma.2022
- Author(s)
  Takahashi K, Sato H, Fujibayashi S, Hayashi A, Kawabata H, Iwamoto H, Goto T, Kitano Y, Mizukami Y, Okumura T.
- Organizer
  第26回国際膵臓学会 Symposium 5 Molecular profiling of pancreatic cancer and application of liquid biopsy to clinical practice
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] 細胞外小胞によるmiR-425の細胞間伝達は上皮間葉形質転換を促進し膵癌進展を制御する2022
- Author(s)
  小山一也、高橋賢治、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、北野陽平、藤谷幹浩、水上裕輔、横山和典、奥村利勝
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 細胞外小胞によるmiR-425の細胞間伝達は上皮間葉形質転換を促進し膵癌進展を制御する.2022
- Author(s)
  小山一也、高橋賢治、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、北野陽平、藤谷幹浩、水上裕輔、奥村利勝.
- Organizer
  第30回日本消化器関連学会週間
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] 消化液に存在する膵癌由来の遺伝子変異検出を目指したリキッドバイオプシー.2022
- Author(s)
  Yusuke Ono, Chiho Maeda, Kenji Takahashi, Hidenori Karasaki, Yusuke Mizukami.
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] Tumor-suppressive effect of mutant GNAS through the restriction of tumor aggressiveness in established pancreatic cancer.2022
- Author(s)
  Kawabata H, Ono Y, Tamamura N, Sato H, Takahashi K, Taniue K, Okada T, Fujibayashi S, Hayashi A, Goto T, Konishi H, Fujiya M, Karasaki H, Liss AS, Mizukami Y, Okumura T.
- Organizer
  DDW2022/AGA2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22KK0125
[Presentation] MicroRNA-491-5p is involved in the resistance to lenvatinib induced under hypoxia in hepatocellular carcinoma2021
- Author(s)
  Mari Satoh, Takayuki Kogure, Masanori Takahashi, Kouji Okada, Kennichi Satoh
- Organizer
  The Liver Meeting 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09401
[Presentation] EUS-FNA検体と血清を用いた膵癌診断における長鎖ノンコーディングRNAの有用性2021
- Author(s)
  高橋賢治、小山一也、川尻はるな、佐藤裕基、藤林周吾、林　明宏、河端秀賢、岩本英孝、後藤拓磨、山北圭介、北野陽平、水上裕輔、奥村利勝
- Organizer
  第52回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] 細胞外小胞EVを用いた新規膵癌体液診断法の開発2021
- Author(s)
  高橋賢治、北野陽平、麻生和信
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K07954
[Presentation] CIRCULATING EXTRACELLULAR VESICLE LNCRNA LINC02280 IS A NOVEL BIOMARKER FOR HUMAN PANCREATIC DUCTAL ADENOCARCINOMA2019
- Author(s)
  Kenji Takahashi, Yu Ota, Yuko Suzuki, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Tsuguhito Ota
- Organizer
  DDW (Digestive Disease Week) 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K09450
[Presentation] 膵癌患者血清中細胞外小胞における新規長鎖機能性RNAのliquid biopsyとしての有用性2019
- Author(s)
  高橋賢治、太田雄、小山一也、鈴木裕子、岩本英孝、山北圭介、北野陽平、太田嗣人
- Organizer
  第50回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K09450
[Presentation] 膵癌における血清細胞外小胞中長鎖機能性RNAのLiquid biopsyとしての有用性の検討2018
- Author(s)
  高橋賢治、北野陽平、太田嗣人
- Organizer
  第104回日本消化器病学会総会　パネルディスカッション11「膵臓癌の新規スクリーニング法の開発と有効性の比較（IPMNを含む）」
- Data Source
  KAKENHI-PROJECT-15K19303
[Presentation] 血清中細胞外小胞EVにおける長鎖機能性RNAの膵癌バイオマーカーとしての有用性の検討2017
- Author(s)
  高橋賢治、太田雄、水元克俊、鈴木裕子、岩本英孝、山北圭介、北野陽平、牧野雄一
- Organizer
  第48回日本膵臓学会大会　ミニシンポジウム 2-1　膵癌の早期診断・治療の現状と展望
- Data Source
  KAKENHI-PROJECT-15K19303
[Presentation] Long Non-coding RNA HULC Derived From Circulating Extracellular Vesicles Would Correlate With Tumor Invasion and Metastasis in Patients With Pancreatic Cancer2017
- Author(s)
  Kenji Takahashi, Yu Ota, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitan, Yuichi Makino
- Organizer
  The 48th Annual Meeting of American Pancreatic Association
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19303
[Presentation] microRNA-133b mediates epithelial-mesenchymal transition via regulation of extracellular vesicle long non-coding RNA HULC in human pancreatic cancer2016
- Author(s)
  Kenji Takahashi, Yu Ota, Yuko Suzuki, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Yuichi Makino and Masakazu Haneda
- Organizer
  The 47th annual meeting of the Japan Pancreas Society & The 20th meeting of the International Association of Pancreatology & The 6th meeting of the Asian Oceanic Pancreatic Association
- Place of Presentation
  仙台、日本
- Year and Date
  2016-08-04
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19303
[Presentation] ヒト近位尿細管細胞において、亜鉛はTGF-β1誘導線維化を抑制しHIF-1 target遺伝子発現を増強する。2016
- Author(s)
  別所瞭一, 前田愛実, 滝山由美, Kuralay. K. Atageldiyeva, 柳町剛司、長南茉欧, 高橋耕平, 酒井健太郎, 中村知伸, 永島優樹, 竹田安孝、辻賢, 本庄潤, 藤田征弘, 安孫子亜津子, 羽田勝計。
- Organizer
  第 59 回日本糖尿病学会年次学術集会
- Place of Presentation
  京都
- Year and Date
  2016-05-19
- Data Source
  KAKENHI-PROJECT-15K09372
[Presentation] Extracellular vesicle-encapsulated long non-coding RNA HULC modulates epithelial mesenchymal transition in human pancreatic cancer2015
- Author(s)
  Kenji Takahashi, Yu Ota, Yuko Suzuki, Hidetaka Iwamoto, Keisuke Yamakita, Yohei Kitano, Ryuji Sudo, Yosui Tamaki, Mitsuyoshi Okada, Kazunobu Aso, Yuichi Makino, Masakazu Haneda
- Organizer
  DDW (Digestive Disease Week) 2015
- Place of Presentation
  Walter E. Washington Convention Center in Washington, DC, USA.
- Year and Date
  2015-05-16
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K19303

1. 水上裕輔 (30400089)

# of Collaborated Projects: 6 results

# of Collaborated Products: 48 results
2. 小野裕介 (40742648)

# of Collaborated Projects: 6 results

# of Collaborated Products: 19 results
3. Kogure Takayuki (70400330)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
4. 谷上賢瑞 (90648627)

# of Collaborated Projects: 4 results

# of Collaborated Products: 4 results
5. 嘉数英二 (20509377)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TAKIYAMA YUMI (00396350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 世良俊博 (40373526)

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8. 中村匡徳 (20448046)

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9. 佐藤麻理 (20846018)

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10. 藤井聡 (90291228)

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11. 河端秀賢 (50548691)

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# of Collaborated Products: 8 results
12. 安藤勝祥 (70548677)

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13. 小西弘晃 (30777181)

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14. 藤谷幹浩 (80322915)

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15. 岩本英孝 (10596274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
16. 林明宏

# of Collaborated Projects: 0 results

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17. 佐藤裕基

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
18. 秋光信佳

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# of Collaborated Products: 1 results

Takashashi Kenji 高橋 賢治

Takahashi Kenji 高橋 賢治

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膵癌分子サブタイプに関わるncRNAの探索と分子診断および創薬への応用Principal Investigator

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The clinical applications of long non-coding RNA and extracellular vesicles to diagnosis and therapy for pancreatic cancerPrincipal Investigator

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Analysis of EV encapsulated long non-coding RNA as the liquid biopsy for pancreatic cancerPrincipal Investigator

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EV mediated transfer of long non-coding RNA in pancreatic cancer developmentPrincipal Investigator

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[Book] 胆と膵 Vol.44No.7(2023-7)2023

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[Book] 日本臨牀 増刊号 膵癌・胆道癌2023 上 膵癌編2023

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[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各 論2023

Takashashi Kenji 高橋賢治

Takahashi Kenji 高橋賢治

[Book] 日本臨牀　増刊号　膵癌・胆道癌2023　上　膵癌編2023

[Book] 膵癌・胆道癌 2023 (上) 膵癌編 ―基礎・臨床の最新研究動向― II.各論2023