Hayashi Kotaro 林光太朗

Researcher Number	00780660
Affiliation (based on the past Project Information) *help	2023: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 2017 – 2021: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), ナノ医療イノベーションセンター, 研究員 2016: 公益財団法人川崎市産業振興財団(ナノ医療イノベーションセンター), 川崎市産業振興財団, 研究員
Review Section/Research Field	Principal Investigator Basic Section 90120:Biomaterials-related / Biomedical engineering/Biomaterial science and engineering Except Principal Investigator Medium-sized Section 90:Biomedical engineering and related fields
Keywords	Principal Investigator 核酸医薬 / 核酸デリバリー / 機能性高分子 / バイオマテリアル Except Principal Investigator アンチジーン核酸 / 生体適合性高分子 / 機能性核酸 / 核酸医薬デリバリー / 脳疾患 / 核酸デリバリー / 核酸医薬 / ナノ医薬 / 薬物送達システム

Development of advanced nanomedicines for brain-targeted oligonucleotide delivery
- Principal Investigator
  
  Miyata Kanjiro
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Review Section
  
  Medium-sized Section 90:Biomedical engineering and related fields
- Research Institution
  The University of Tokyo
Construction of nucleic acid delivery carrier using biodegradable block copolymersPrincipal Investigator
- Principal Investigator
  
  Hayashi Kotaro
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine
Construction of polymeric micelle with thermo-responsive poly(amino acid)sPrincipal Investigator
- Principal Investigator
  
  Hayashi Kotaro
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Biomedical engineering/Biomaterial science and engineering
- Research Institution
  Kawasaki Institute of Industrial Promotion Innovation Center of NanoMedicine

All 2022 2021 2020 2019 2018 2017 2016

All Journal Article Presentation Book Patent

[Book] 中分子創薬に向けたDDS開発の新展開2022
- Author(s)
  杉林堅次、他
- Total Pages
  239
- Publisher
  シーエムシー出版
- ISBN
  9784781316598
- Data Source
  KAKENHI-PROJECT-20H00658
[Journal Article] Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)-<i>b</i>-poly(<scp>l</scp>-lysine)2021
- Author(s)
  Chaya Hiroyuki、Naito Mitsuru、Cho Masaru、Toh Kazuko、Hayashi Kotaro、Fukushima Shigeto、Yamasaki Yuichi、Kataoka Kazunori、Miyata Kanjiro
- Journal Title
  
  Biomacromolecules
  
  Volume: 23 Issue: 1 Pages: 388-397
- DOI
  10.1021/acs.biomac.1c01344
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20H00658
[Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells.2019
- Author(s)
  Y. Yi, H. J. Kim, M. Zheng, P. Mi, M. Naito, B. S. Kim, H. S. Min, K. Hayashi, F. Perche, K. Toh, X. Liu, Y. Mochida, H. Kinoh, H. Cabral, K. Miyata, K. Kataoka
- Journal Title
  
  J. Control. Release
  
  Volume: 295 Pages: 268-277
- DOI
  10.1016/j.jconrel.2019.01.006
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-18K18378, KAKENHI-PROJECT-17H02098, KAKENHI-PROJECT-18H04170, KAKENHI-PROJECT-20K20386, KAKENHI-PROJECT-18K18391, KAKENHI-PROJECT-18K18379
[Journal Article] Self-Assembly of siRNA/PEG-b-Catiomer at Integer Molar Ratio into 100 nm-Sized Vesicular Polyion Complexes (siRNAsomes) for RNAi and Codelivery of Cargo Macromolecules2019
- Author(s)
  Kim Beob Soo、Chuanoi Sayan、Suma Tomoya、Anraku Yasutaka、Hayashi Kotaro、Naito Mitsuru、Kim Hyun Jin、Kwon Ick Chan、Miyata Kanjiro、Kishimura Akihiro、Kataoka Kazunori
- Journal Title
  
  Journal of the American Chemical Society
  
  Volume: 141 Issue: 8 Pages: 3699-3709
- DOI
  10.1021/jacs.8b13641
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K20109, KAKENHI-PROJECT-17H02098, KAKENHI-PROJECT-17H04742, KAKENHI-PROJECT-17K20094, KAKENHI-PROJECT-18K19900, KAKENHI-PROJECT-18K18391
[Journal Article] Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor2019
- Author(s)
  Beob Soo Kim, Hyun Jin Kim, Shigeto Osawa, Kotaro Hayashi, Kazuko Toh, Mitsuru Naito, Hyun Su Min, Yu Yi, Ick Chan Kwon, Kazunori Kataoka, Kanjiro Miyata
- Journal Title
  
  ACS Biomaterials Science & Engineering
  
  Volume: 5 Issue: 11 Pages: 5770-5780
- DOI
  10.1021/acsbiomaterials.9b00384
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18391
[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019
- Author(s)
  Watanabe Sumiyo、Hayashi Kotaro、Toh Kazuko、Kim Hyun Jin、Liu Xueying、Chaya Hiroyuki、Fukushima Shigeto、Katsushima Keisuke、Kondo Yutaka、Uchida Satoshi、Ogura Satomi、Nomoto Takahiro、et al.
- Journal Title
  
  Nature Communications
  
  Volume: 10 Issue: 1 Pages: 1894-1894
- DOI
  10.1038/s41467-019-09856-w
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K18383, KAKENHI-PROJECT-17KT0048, KAKENHI-PROJECT-19K12799, KAKENHI-PROJECT-17K20086, KAKENHI-PROJECT-18K18391, KAKENHI-PROJECT-17KK0102, KAKENHI-PROJECT-18H04163, KAKENHI-PROJECT-16H03178, KAKENHI-PROJECT-17H03582, KAKENHI-PROJECT-18H02797, KAKENHI-PROJECT-18H03529, KAKENHI-PROJECT-17H04743, KAKENHI-PROJECT-17K07234, KAKENHI-PROJECT-17H02098
[Patent] 刺激応答性ポリマー2020
- Inventor(s)
  林光太朗、片岡一則
- Industrial Property Rights Holder
  川崎市産業振興財団
- Industrial Property Rights Type
  特許
- Filing Date
  2020
- Overseas
- Data Source
  KAKENHI-PROJECT-18K18391
[Patent] 刺激応答性ポリマー2019
- Inventor(s)
  林光太郎、片岡一則
- Industrial Property Rights Holder
  川崎市産業振興財団
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K18391
[Patent] 刺激応答性ポリマー2019
- Inventor(s)
  林光太朗・片岡一則
- Industrial Property Rights Holder
  川崎市産業振興財団
- Industrial Property Rights Type
  特許
- Filing Date
  2019
- Overseas
- Data Source
  KAKENHI-PROJECT-18K18391
[Patent] 刺激応答性ポリマー2018
- Inventor(s)
  林光太朗、片岡一則
- Industrial Property Rights Holder
  川崎市産業振興財団
- Industrial Property Rights Type
  特許
- Filing Date
  2018
- Data Source
  KAKENHI-PROJECT-16H07494
[Presentation] 1分子核酸医薬内包ユニットポリイオンコンプレックスの血中滞留性向上を指向したブロック共重合体のカチオン鎖長設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山﨑裕一, 片岡一則, 宮田完二郎
- Organizer
  第71回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中滞留性向上を目指した1分子siRNA内包ユニットポリイオンコンプレックスの設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山崎裕一, 片岡一則, 宮田完二郎
- Organizer
  日本核酸医薬学会第7回年会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中滞留性向上を目指した１分子siRNA内包ユニットポリイオンコンプレックスの設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 山崎裕一, 片岡一則, 宮田完二郎
- Organizer
  第27回創剤フォーラム若手研究会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 1分子核酸内包ユニットポリイオンコンプレックスの血中滞留性向上を指向した分子設計2022
- Author(s)
  内藤瑞, 茶谷洋行, 張賢, 藤加珠子, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第71回高分子討論会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] Prolonged blood circulation of siRNA-loaded ultrasmall polymeric nanocarriers by fine-tuning of oligonucleotide structures2021
- Author(s)
  H. Chaya, M. Naito, K. Toh, B. S. Kim, K. Hayashi, S. Fukushima, K. Kataoka, K. Miyata
- Organizer
  The 48th Annual Meeting of the Controlled Release Society
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 血中動態の改善を指向した化学修飾核酸siRNA封入ユニットポリイオンコンプレックスの構築2021
- Author(s)
  茶谷洋行, 内藤瑞, 藤加珠子, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] 1分子核酸内包キャリアの血中滞留性向上を指向したブロック共重合体の精密設計2021
- Author(s)
  茶谷洋行, 内藤瑞, 張賢, 藤加珠子, キムボブス, キムヒョンジン, 林光太朗, 福島重人, 片岡一則, 宮田完二郎
- Organizer
  第70回高分子討論会
- Data Source
  KAKENHI-PROJECT-20H00658
[Presentation] ポリアミノ酸骨格を有する温度応答性ポリマーの合成と機能評価2019
- Author(s)
  林光太朗・片岡一則
- Organizer
  第68回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] siRNA 送達に向けたカチオン性ポリアミノ酸の検討2019
- Author(s)
  林光太朗、福島重人、西山伸宏、宮田完二郎、片岡一則
- Organizer
  第68回高分子学会討論会
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] ポリアミノ酸骨格を有する温度応答性ポリマーの合成と機能評価2019
- Author(s)
  林光太朗、片岡一則
- Organizer
  第68回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] カチオン性ブロック共重合体の重合度がsiRNA会合体の構造に与える効果2019
- Author(s)
  林光太朗、福島重人、長田健介、西山伸宏、宮田完二郎、片岡一則
- Organizer
  第29回バイオ高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] siRNA 送達に向けたカチオン性ポリアミノ酸の検討2018
- Author(s)
  林光太朗・福島重人・西山伸宏・宮田完二郎・片岡一則
- Organizer
  第67回高分子学会討論会
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] ナノメディシンへの展開に向けた siRNA とブロック共重合体からなる最小単位の会合体形成2018
- Author(s)
  林光太朗・福島重人・長田健介・西山伸宏・宮田完二郎・片岡一則
- Organizer
  第67回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] 核酸医薬の送達に向けた RNA とブロック共重合体の会合の物理化学的解析2018
- Author(s)
  林光太朗・福島重人・長田健介・西山伸宏・宮田完二郎・片岡一則
- Organizer
  第28回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-18K18391
[Presentation] Effect of ionomer rigidity on the complex formation with block-catiomer and RNAs2017
- Author(s)
  Kotaro Hayashi, Shigeto Fukushima, Hiroyasu Takemoto, Kensuke Osada, Nobuhiro Nishiyama, Kanjiro Miyata, Kazunori Kataoka
- Organizer
  253rd ACS National meeting & Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07494
[Presentation] RNA鎖と重合度の異なるカチオン性ブロック共重合体の会合挙動の解析2017
- Author(s)
  林光太朗、福島重人、長田健介、西山伸宏、宮田完二郎、片岡一則
- Organizer
  第66回高分子学会年次大会
- Data Source
  KAKENHI-PROJECT-16H07494
[Presentation] siRNAとブロック共重合体のイオン性会合体における会合数の制御2016
- Author(s)
  林光太朗
- Organizer
  第65回高分子討論会
- Place of Presentation
  神奈川大学
- Year and Date
  2016-09-14
- Data Source
  KAKENHI-PROJECT-16H07494
[Presentation] Control of nanoparticle assembly between nucleic acid and block-catiomer2016
- Author(s)
  Kotaro Hayashi
- Organizer
  3rd International Conference on Biomaterials Science in Tokyo
- Place of Presentation
  The University of Tokyo
- Year and Date
  2016-11-28
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H07494

1. Miyata Kanjiro (50436523)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
2. 谷口陽祐 (00452714)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 劉学瑩 (30777470)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. 藤加珠子 (90342732)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. KISHIMURA Akihiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
6. 藤和珠子

# of Collaborated Projects: 0 results

# of Collaborated Products: 8 results
7. 喜納宏昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
8. 野本貴大

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Hayashi Kotaro 林 光太朗

Research Projects

Research Products

Co-Researchers

Development of advanced nanomedicines for brain-targeted oligonucleotide delivery

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of nucleic acid delivery carrier using biodegradable block copolymersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Construction of polymeric micelle with thermo-responsive poly(amino acid)sPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 中分子創薬に向けたDDS開発の新展開2022

Author(s)

Total Pages

Publisher

ISBN

Data Source

[Journal Article] Dynamic Stabilization of Unit Polyion Complexes Incorporating Small Interfering RNA by Fine-Tuning of Cationic Block Length in Two-Branched Poly(ethylene glycol)-<i>b</i>-poly(<scp>l</scp>-lysine)2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Glucose-linked sub-50-nm unimer polyion complex-assembled gold nanoparticles for targeted siRNA delivery to glucose transporter 1-overexpressing breast cancer stem-like cells.2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Self-Assembly of siRNA/PEG-b-Catiomer at Integer Molar Ratio into 100 nm-Sized Vesicular Polyion Complexes (siRNAsomes) for RNAi and Codelivery of Cargo Macromolecules2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dually stabilized triblock copolymer micelles with hydrophilic shell and hydrophobic interlayer for systemic antisense oligonucleotide delivery to solid tumor2019

Author(s)

Journal Title

DOI

Data Source

[Journal Article] In vivo rendezvous of small nucleic acid drugs with charge-matched block catiomers to target cancers2019

Author(s)

Journal Title

DOI

Data Source

[Patent] 刺激応答性ポリマー2020

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 刺激応答性ポリマー2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 刺激応答性ポリマー2019

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Patent] 刺激応答性ポリマー2018

Inventor(s)

Industrial Property Rights Holder

Industrial Property Rights Type

Filing Date

Data Source

[Presentation] 1分子核酸医薬内包ユニットポリイオンコンプレックスの血中滞留性向上を指向したブロック共重合体のカチオン鎖長設計2022

Author(s)

Organizer

Hayashi Kotaro 林光太朗