NAGASHIMA Hiroaki 長嶋宏明

… Alternative Names

Nagashima Hiroaki 長嶋宏明

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Researcher Number	00794950
Other IDs
Affiliation (Current)	2025: 神戸大学, 医学研究科, 助教
Affiliation (based on the past Project Information) *help	2021 – 2025: 神戸大学, 医学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 56010:Neurosurgery-related Except Principal Investigator Basic Section 56010:Neurosurgery-related
Keywords	Principal Investigator Wee1 / Glioma / CDKN2A / PAR / Temozolomide / DNA damage / DNA複製異常 / 悪性神経膠腫 / WEE1 / グリオーマ … More / テモゾロミド / PARG / temozolomide / IDH wild-type … More Except Principal Investigator グリオーマ / microbiota / ketogenic diet / glioma / 腸内細菌 / ケトン食 / thick wall / thin wall / mechanism / cerebral aneurysm / myoglobin / 光免疫療法 / Drug resistance / Glioblastoma / Ror1 / EGFR / 低酸素 / 膜脂質代謝 / 髄芽腫 / medulloblastoma / D47 / sCD163 / macrophage / SIRPa / マクロファージ / CD163 / M2マクロファージ Less

Elucidation of drug resistance mechanisms and development of novel therapeutic strategies for EGFR-mutant glioblastoma
- Principal Investigator
  
  堀達雄
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Establishment of near-infrared photoimmunotherapy targeting the CD44 gene for diffuse midline glioma
- Principal Investigator
  
  田中宏知
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Elucidation of the pathogenesis of CDKN2A co-deleted gliomas and development of a novel targeting therapyPrincipal Investigator
- Principal Investigator
  
  長嶋宏明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Elucidating the novel pathophysiology of thickened and thinned walls in cerebral aneurysms through transcriptome analysis and chemotaxis assay
- Principal Investigator
  
  木村英仁
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Microbiota of ketogenic diet in glioblastoma patients and enhancement effect of synbiotics
- Principal Investigator
  
  篠山隆司
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Molecular mechanism of membrane lipid remodeling in hypoxic glioma cells
- Principal Investigator
  
  田中一寛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Development of new treatments for medulloblastoma targeting macrophage
- Principal Investigator
  
  Nishihara Masamitsu
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University
Targeting PARG in malignant glioma therapyPrincipal Investigator
- Principal Investigator
  
  Nagashima Hiroaki
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 56010:Neurosurgery-related
- Research Institution
  Kobe University

All 2025 2024 2023 2022

All Journal Article Presentation

[Journal Article] A morphological features-based nomogram for predicting facial nerve function in the immediate postoperative period after vestibular schwannoma surgery2025
- Author(s)
  Fujita Yuichi、Uozumi Yoichi、Fujimoto Yosuke、Nagashima Hiroaki、Kohta Masaaki、Tanaka Kazuhiro、Kimura Hidehito、Fujita Atsushi、Kohmura Eiji、Sasayama Takashi
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: - Issue: 2 Pages: 1-10
- DOI
  10.1007/s11060-025-04984-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09258, KAKENHI-PROJECT-24K12243
[Journal Article] Postoperative Air in the Cisterns or Ventricles Predicts Early Leptomeningeal Disease of Brain Metastases: A Retrospective Study2025
- Author(s)
  Ikeuchi Yusuke、Nishihara Masamitsu、Hosoda Kohkichi、Ashida Noriaki、Yamanishi Shunsuke、Nagashima Hiroaki、Tanaka Kazuhiro、Muragaki Yoshihiro、Sasayama Takashi
- Journal Title
  
  World Neurosurgery
  
  Volume: 193 Pages: 903-910
- DOI
  10.1016/j.wneu.2024.10.118
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-24K12243
[Journal Article] Association of preoperative seizures with reduced expression of soluble CD163, an M2 macrophage marker, in the cerebrospinal fluid in isocitrate dehydrogenase wild-type glioblastoma2024
- Author(s)
  Yamanishi Shunsuke、Nagashima Hiroaki、Tanaka Kazuhiro、Uno Takiko、Ikeuchi Yusuke、Iwahashi Hirofumi、Hashiguchi Mitsuru、Horii Shintaro、Itoh Tomoo、Muragaki Yoshihiro、Sasayama Takashi
- Journal Title
  
  Journal of Neuro-Oncology
  
  Volume: 171 Issue: 1 Pages: 95-103
- DOI
  10.1007/s11060-024-04837-6
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-23K08542, KAKENHI-PROJECT-24K12243, KAKENHI-PROJECT-24K19528
[Journal Article] Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases2024
- Author(s)
  Fujimoto Yosuke、Fujita Yuichi、Tanaka Kazuhiro、Nagashima Hiroaki、Yamanishi Shunsuke、Ikeuchi Yusuke、Iwahashi Hirofumi、Sanada Shoji、Muragaki Yoshihiro、Sasayama Takashi
- Journal Title
  
  Neurosurgery
  
  Volume: 13 Issue: 6 Pages: 1374-1385
- DOI
  10.1227/neu.0000000000003247
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-24K12243, KAKENHI-PROJECT-24K19528
[Journal Article] Potential of GSPT1 as a novel target for glioblastoma therapy2024
- Author(s)
  Sasayama Takashi、Hamada Takeshi、Tanaka Kazuhiro、Nagashima Hiroaki、Yamanishi Shunsuke、Ueyama Takehiko
- Journal Title
  
  Cell Death & Disease
  
  Volume: 15 Issue: 8 Pages: 1-11
- DOI
  10.1038/s41419-024-06967-1
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-24K12243
[Journal Article] <i>CDKN2A/B</i> Homozygous Deletion Sensitizes IDH-Mutant Glioma to CDK4/6 Inhibition2024
- Author(s)
  Nasser Ali M.、Melamed Lisa、Wetzel Ethan A.、Chang Jenny Chia-Chen、Nagashima Hiroaki、Kitagawa Yosuke、Muzyka Logan、Wakimoto Hiroaki、Cahill Daniel P.、Miller Julie J.
- Journal Title
  
  Clinical Cancer Research
  
  Volume: 30 Issue: 14 Pages: 2996-3005
- DOI
  10.1158/1078-0432.ccr-24-0562
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16630
[Journal Article] Association between accumulation of 2-hydroxyglutarate detected by MR spectroscopy and preoperative seizure in IDH-mutant glioma2024
- Author(s)
  Nagashima Hiroaki、Tanaka Kazuhiro、Yamanishi Shunsuke、Hashiguchi Mitsuru、Iwahashi Hirofumi、Uno Takiko、Somiya Yuichiro、Komatsu Masato、Itoh Tomoo、Sasaki Ryohei、Sasayama Takashi
- Journal Title
  
  Journal of Neurosurgery
  
  Volume: 712-721 Pages: 712-721
- DOI
  10.3171/2024.6.jns24166
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K06430, KAKENHI-PROJECT-21K07642, KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-20KK0192, KAKENHI-PROJECT-23K08542, KAKENHI-PROJECT-24K12243, KAKENHI-PROJECT-24K19528, KAKENHI-PROJECT-24KK0154
[Journal Article] Mutant IDH inhibitors induce lineage differentiation in IDH-mutant oligodendroglioma2024
- Author(s)
  Spitzer Avishay、Gritsch Simon、Nomura Masashi、Nagashima Hiroaki, Landau Dan A.、Ligon Keith L.、Cahill Daniel P.、Suva Mario L.、Tirosh Itay
- Journal Title
  
  Cancer Cell
  
  Volume: 42 Issue: 5 Pages: 904-914.e9
- DOI
  10.1016/j.ccell.2024.03.008
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16630
[Journal Article] Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.2023
- Author(s)
  Ishikawa T, Ogura Y, Tanaka K, Nagashima H, Sasayama T, Endo M, Minami Y.
- Journal Title
  
  Cancer Sci.
  
  Volume: 114 Issue: 2 Pages: 561-561
- DOI
  10.1111/cas.15630
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-23K08542
[Journal Article] 2-Hydroxyglutarate magnetic resonance spectroscopy in adult brainstem glioma.2023
- Author(s)
  Iwahashi H, Nagashima H, Tanaka K, Uno T, Hashiguchi M, Maeyama M, Somiya Y, Komatsu M, Hirose T, Itoh T, Sasaki R, Sasayama T.
- Journal Title
  
  J Neurosurg
  
  Volume: 1 Issue: 2 Pages: 1-1
- DOI
  10.3171/2022.12.jns221954
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-20K09369, KAKENHI-PROJECT-21K16630, KAKENHI-PROJECT-20KK0192, KAKENHI-PROJECT-20K06430, KAKENHI-PROJECT-21K07594, KAKENHI-PROJECT-21K07642, KAKENHI-PROJECT-23K08542, KAKENHI-PROJECT-20K08108, KAKENHI-PROJECT-20K21576, KAKENHI-PROJECT-23K24287
[Journal Article] Glutamic Acid and Total Creatine as Predictive Markers for Epilepsy in Glioblastoma by Using Magnetic Resonance Spectroscopy Before Surgery2022
- Author(s)
  Hashiguchi Mitsuru、Tanaka Kazuhiro、Nagashima Hiroaki、Fujita Yuichi、Tanaka Hirotomo、Kohta Masaaki、Nakai Tomoaki、Uozumi Yoichi、Maeyama Masahiro、Somiya Yuichiro、Kohmura Eiji、Sasayama Takashi
- Journal Title
  
  World Neurosurgery
  
  Volume: 160 Pages: 501-501
- DOI
  10.1016/j.wneu.2022.01.056
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20K09369, KAKENHI-PROJECT-22K09284, KAKENHI-PROJECT-20K09389
[Presentation] 播種にて発症した転移性脳腫瘍の特徴2024
- Author(s)
  篠山隆司、田中一寛、長嶋宏明、山西俊介、池内佑介、伊藤智雄
- Organizer
  日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-24K12243
[Presentation] GSPT1をターゲットとしたグリオーマの新規治療の可能性2024
- Author(s)
  篠山隆司、濱田　猛、長嶋宏明、田中一寛、山西俊介、上山健彦
- Organizer
  第24回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] GSPT1をターゲットとしたグリオーマの新規治療の可能性2024
- Author(s)
  篠山隆司、濱田　猛、長嶋宏明、田中一寛、山西俊介、上山健彦
- Organizer
  日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-24K12243
[Presentation] Potential of GSPT1 as a novel target for glioblastoma therapy2024
- Author(s)
  Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama
- Organizer
  29th Annual Meeting of the Society for Neuro-Oncology
- Data Source
  KAKENHI-PROJECT-24K12243
[Presentation] 中枢神経悪性リンパ腫における髄液IL-6とIL-10の臨床的意義について2024
- Author(s)
  篠山隆司、山西俊介、長嶋宏明、池内佑介、田中一寛、西原賢在
- Organizer
  第42回日本脳腫瘍学会学術集会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 膠芽腫患者における造影病変全摘出後のFLAIR高信号域からの再発と代謝物変化2024
- Author(s)
  田中一寛、長嶋宏明、山西俊介、池内佑介、藤本陽介、篠山隆司
- Organizer
  第83回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] Clinical effect of CD25 on the MTX-based chemosensitivity of primary central nervous system lymphoma2024
- Author(s)
  2Shunsuke Yamanishi, Hiroaki Nagashima, Kazuhiro Tanaka, Takashi Sasayama
- Organizer
  29th Annual Meeting of the Society for Neuro-Oncology, November 21-24, 2024, Houston, Texas
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] Extended resection improves patient survival outcomes after gross-total resection of glioblastoma2024
- Author(s)
  Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Yoshihiro Muragaki, and Takashi Sasayama
- Organizer
  29th Annual Meeting of the Society for Neuro-Oncology, November 21-24, 2024, Houston, Texas
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 脳幹グリオーマに対する診断・治療戦略2024
- Author(s)
  篠山隆司、田中一寛、長嶋宏明、山西俊介、池内佑介、岩橋洋文、西原賢在、河村淳史
- Organizer
  一般社団法人日本脳神経外科学会第83回学術総会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 中枢神経系びまん性大細胞型B細胞性リンパ腫の化学療法感受性に対するCD25の臨床的影響2024
- Author(s)
  長嶋宏明、田中一寛、山西俊介、篠山隆司
- Organizer
  第24回日本分子脳神経外科学会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 中枢神経悪性リンパ腫における髄液IL-6とIL-10の臨床的意義について2024
- Author(s)
  篠山隆司1)、山西俊介1)、長嶋宏明1)、池内佑介1)、田中一寛1)、西原賢在2)
- Organizer
  日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-24K12243
[Presentation] 播種にて発症した転移性脳腫瘍の特徴2024
- Author(s)
  篠山隆司、田中一寛、長嶋宏明、山西俊介、池内佑介、伊藤智雄
- Organizer
  第43回　日本脳腫瘍病理学会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 播種にて発症した転移性脳腫瘍の特徴2024
- Author(s)
  篠山隆司、田中一寛、長嶋宏明、山西俊介、池内佑介、伊藤智雄
- Organizer
  日本癌治療学会
- Data Source
  KAKENHI-PROJECT-24K12243
[Presentation] 側頭葉膠芽腫に対する側頭葉内側部分は切除すべきか？温存すべきか？2024
- Author(s)
  田中一寛、長嶋宏明、山西俊介、藤本陽介、篠山隆司
- Organizer
  第42回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] Potential of GSPT1 as a novel target for glioblastoma therapy2024
- Author(s)
  Takashi Sasayama, Takeshi Hamada, Kazuhiro Tanaka, Hiroaki Nagashima, Shunsuke Yamanishi, Takehiko Ueyama
- Organizer
  29th Annual Meeting of the Society for Neuro-Oncology, November 21-24, 2024, Houston, Texas
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] Extended resection improves patient survival outcomes after gross-total resection of glioblastoma2024
- Author(s)
  Tanaka K, Nagashima H, Yamanishi S, Muragaki Y, Sasayama T
- Organizer
  29th Annual Scientific Meeting and Education Day of the society for Neuro-Oncology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023
- Author(s)
  田中一寛、長嶋宏明、山西俊介、伊藤智雄、篠山隆司
- Organizer
  第82回日本脳神経外科学会学術総会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] 成人diffuse midline gliomaにおけるH3K27M変異と生命予後2023
- Author(s)
  田中一寛、長嶋宏明、篠山隆司
- Organizer
  第82回日本脳神経外科学会学学術総会
- Data Source
  KAKENHI-PROJECT-22K09284
[Presentation] 一次運動野近傍にある悪性脳腫瘍に対する術中画像支援と摘出術2023
- Author(s)
  田中一寛、長嶋宏明、山西俊介、藤本陽介、篠山隆司
- Organizer
  第41回日本脳腫瘍学会
- Data Source
  KAKENHI-PROJECT-23K08542
[Presentation] 3テスラMRSによるグリオーマ術前てんかん予測因子2023
- Author(s)
  長嶋宏明、田中一寛、篠山隆司
- Organizer
  第82回日本脳神経外科学会学学術総会
- Data Source
  KAKENHI-PROJECT-22K09284

1. 篠山隆司 (10379399)

# of Collaborated Projects: 7 results

# of Collaborated Products: 25 results
2. 田中一寛 (70467661)

# of Collaborated Projects: 7 results

# of Collaborated Products: 24 results
3. 藤田祐一 (40895132)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. Nishihara Masamitsu (20452493)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
5. 高橋政友 (30844419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 堀達雄 (00900169)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 田中宏知 (10569239)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. 木村英仁 (90514753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
9. 佐々木良平

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 赤坂浩亮

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 魚住洋一

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

NAGASHIMA Hiroaki 長嶋 宏明

Nagashima Hiroaki 長嶋 宏明

Research Projects

Research Products

Co-Researchers

Elucidation of drug resistance mechanisms and development of novel therapeutic strategies for EGFR-mutant glioblastoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Establishment of near-infrared photoimmunotherapy targeting the CD44 gene for diffuse midline glioma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidation of the pathogenesis of CDKN2A co-deleted gliomas and development of a novel targeting therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Elucidating the novel pathophysiology of thickened and thinned walls in cerebral aneurysms through transcriptome analysis and chemotaxis assay

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Microbiota of ketogenic diet in glioblastoma patients and enhancement effect of synbiotics

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Molecular mechanism of membrane lipid remodeling in hypoxic glioma cells

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of new treatments for medulloblastoma targeting macrophage

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Targeting PARG in malignant glioma therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] A morphological features-based nomogram for predicting facial nerve function in the immediate postoperative period after vestibular schwannoma surgery2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Postoperative Air in the Cisterns or Ventricles Predicts Early Leptomeningeal Disease of Brain Metastases: A Retrospective Study2025

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Association of preoperative seizures with reduced expression of soluble CD163, an M2 macrophage marker, in the cerebrospinal fluid in isocitrate dehydrogenase wild-type glioblastoma2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Clinical Benefits of Photodynamic Therapy Using Talaporfin Sodium in Patients With Isocitrate Dehydrogenase-Wildtype Diagnosed Glioblastoma: A Retrospective Study of 100 Cases2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Potential of GSPT1 as a novel target for glioblastoma therapy2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] <i>CDKN2A/B</i> Homozygous Deletion Sensitizes IDH-Mutant Glioma to CDK4/6 Inhibition2024

Author(s)

NAGASHIMA Hiroaki 長嶋宏明

Nagashima Hiroaki 長嶋宏明