FUJIWARA HIROAKI 藤原弘明

… Alternative Names

Fujiwara Hiroaki 藤原弘明

Less

Researcher Number	00814500
Affiliation (Current)	2025: 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行)
Affiliation (based on the past Project Information) *help	2025: 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) 2019 – 2023: 公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) 2020: 東京大学, 医学部附属病院, 特任臨床医 2019: 公益財団法人朝日生命成人病研究所, 消化器内科, 教授 2018: 東京大学, 医学部附属病院, 特任臨床医
Review Section/Research Field	Principal Investigator Basic Section 53010:Gastroenterology-related Except Principal Investigator Basic Section 53010:Gastroenterology-related
Keywords	Principal Investigator エピゲノム / 代謝 / 胆管癌 / IDH / IDH変異 / 肝内胆管癌 Except Principal Investigator 膵癌 / 原発性硬化性胆管炎 / LIGHT / TNFRSF14 … More / うっ血肝 / FALD / Fontan / クロマチン / エピゲノム / 膵臓癌 / 胆道癌 / 肝内胆管癌 / 胆管癌 Less

代謝とエピゲノムを基軸とした肝内胆管発癌機構の解明と新規治療標的の探索Principal Investigator
- Principal Investigator
  
  藤原弘明
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The Institute for Adult Diseases Asahi Life Foundation
Identification of pathogenesis and therapeutic targets in fontan-associated liver disease (FALD)
- Principal Investigator
  
  中塚拓馬
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
原発性硬化性胆管炎における分子生物学的基盤の解明
- Principal Investigator
  
  金井祥子
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
IDH変異陽性肝内胆管癌における特異的分子基盤の解明Principal Investigator
- Principal Investigator
  
  藤原弘明
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The Institute for Adult Diseases Asahi Life Foundation
Comprehensive elucidation of intrahepatic biliary carcinogenesis induced by IDH mutationsPrincipal Investigator
- Principal Investigator
  
  Fujiwara Hiroaki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The Institute for Adult Diseases Asahi Life Foundation
Comprehensive biological network analysis of pancreatic cancer
- Principal Investigator
  
  TATEISHI KEISUKE
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of metabolic reprogramming in intrahepatic cholangiocellular carcinoma
- Principal Investigator
  
  Kogure Hirofumi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo
Analysis of histone modification in patient-derived pancreatic cancer cells.
- Principal Investigator
  
  Nakai Yousuke
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53010:Gastroenterology-related
- Research Institution
  The University of Tokyo

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation Book

[Book] Medical Practice2020
- Author(s)
  藤原弘明、高原楠昊
- Total Pages
  3
- Publisher
  文光堂
- Data Source
  KAKENHI-PROJECT-19K17391
[Journal Article] Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis2024
- Author(s)
  Kanai S, Fujiwara H, Mizuno S, Kishikawa T, Nakatsuka T, Hamada T, Tanaka M, Arita J, Nakai Y, Isayama H, Kasuga M, Tateishi R, Tateishi K, Ushiku T, Hasegawa K, Koike K, Fujishiro M.
- Journal Title
  
  Dig Liver Dis .
  
  Volume: 56(2) Issue: 2 Pages: 305-311
- DOI
  10.1016/j.dld.2023.08.057
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-21K16012, KAKENHI-PROJECT-22K06976, KAKENHI-PROJECT-23K07412, KAKENHI-PROJECT-21H02893
[Journal Article] Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis Carcinogenesis2020
- Author(s)
  Hiroyuki Kato, Keisuke Tateishi*, Hiroaki Fujiwara, Hideaki Ijichi, Keisuke Yamamoto, Takuma Nakatsuka, Miwako Kakiuchi, Makoto Sano, Yotaro Kudo, Yoku Hayakawa, Hayato Nakagawa, Yasuo Tanaka, Motoyuki Otsuka, Yoshihiro Hirata, Makoto Tachibana, Yoichi Shinkai, Kazuhiko Koike
- Journal Title
  
  Cancer Genomics Proteomics
  
  Volume: 17 Issue: 6 Pages: 695705-695705
- DOI
  10.21873/cgp.20224
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18H02419, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-19K22388, KAKENHI-ORGANIZER-17H06423, KAKENHI-PLANNED-17H06424, KAKENHI-PROJECT-19K08435
[Journal Article] Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer2020
- Author(s)
  Takahashi Ryota、Ijichi Hideaki、Sano Makoto、Miyabayashi Koji、Mohri Dai、Kim Jinsuk、Kimura Gen、Nakatsuka Takuma、Fujiwara Hiroaki、Yamamoto Keisuke、Kudo Yotaro、Tanaka Yasuo、Tateishi Keisuke、Nakai Yousuke、Morishita Yasuyuki、Soma Katsura、Takeda Norihiko、Moses Harold L.、Isayama Hiroyuki、Koike Kazuhiko
- Journal Title
  
  Scientific Reports
  
  Volume: 10 Issue: 1 Pages: 1-13
- DOI
  10.1038/s41598-020-78320-3
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07584, KAKENHI-PROJECT-20K08398, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-18K15880
[Journal Article] 5-Aminolevulinic acid-mediated photodynamic activity in patient-derived cholangiocarcinoma organoids2020
- Author(s)
  Fujiwara Hiroaki、Takahara Naminatsu、Tateishi Keisuke、Tanaka Mariko、Kanai Sachiko、Kato Hiroyuki、Nakatsuka Takuma、Yamamoto Keisuke、Kogure Hirofumi、Arita Junichi、Nakai Yousuke、Kasuga Masato、Ushiku Tetsuo、Hasegawa Kiyoshi、Koike Kazuhiko
- Journal Title
  
  Surgical Oncology
  
  Volume: 35 Pages: 484-490
- DOI
  10.1016/j.suronc.2020.10.011
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K08277, KAKENHI-PROJECT-19K17391, KAKENHI-PROJECT-18K07899
[Journal Article] Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2019
- Author(s)
  Fujiwara H、Tateishi K、Misumi K、Hayashi A、Igarashi K、Kato H、Nakatsuka T、Suzuki N、Yamamoto K、Kudo Y、Hayakawa Y、Nakagawa 、Tanaka Y、Ijichi H、Kogure H、Nakai Y、Isayama H、Hasegawa K、Fukayama M、Soga T、Koike K
- Journal Title
  
  Scientific Reports
  
  Volume: 9 Issue: 1 Pages: 18859-18859
- DOI
  10.1038/s41598-019-55211-w
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-19K17391, KAKENHI-PROJECT-19K17478, KAKENHI-PROJECT-17K09454, KAKENHI-PROJECT-18K07899, KAKENHI-PROJECT-18K07900
[Journal Article] Blocking CXCLs?CXCR2 axis in tumor?stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment2019
- Author(s)
  Sano Makoto、Ijichi Hideaki、Takahashi Ryota、Miyabayashi Koji、Fujiwara Hiroaki、Yamada Tomoharu、Kato Hiroyuki、Nakatsuka Takuma、Tanaka Yasuo、Tateishi Keisuke、Morishita Yasuyuki、Moses Harold L.、Isayama Hiroyuki、Koike Kazuhiko
- Journal Title
  
  Oncogenesis
  
  Volume: 8 Issue: 2 Pages: 8-8
- DOI
  10.1038/s41389-018-0117-8
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-17K09454, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-19K08435, KAKENHI-PROJECT-16K07109
[Journal Article] Isocitrate dehydrogenase 1 mutation sensitizes intrahepatic cholangiocarcinoma to the BET inhibitor JQ12018
- Author(s)
  Fujiwara Hiroaki、Tateishi Keisuke、Kato Hiroyuki、Nakatsuka Takuma、Yamamoto Keisuke、Tanaka Yasuo、Ijichi Hideaki、Takahara Naminatsu、Mizuno Suguru、Kogure Hirofumi、Matsubara Saburo、Nakai Yousuke、Koike Kazuhiko
- Journal Title
  
  Cancer Science
  
  Volume: 109 Issue: 11 Pages: 3602-3610
- DOI
  10.1111/cas.13784
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07899, KAKENHI-PROJECT-18K07961, KAKENHI-PROJECT-18K07962, KAKENHI-PROJECT-16K09342, KAKENHI-PROJECT-16K09390, KAKENHI-PROJECT-16K09391
[Presentation] The Possibility of 5-aminolevulinic acid mediated photodynamic diagnosis in cholangiocarcinoma2024
- Author(s)
  Hiroaki Fujiwara, Naminatsu Takahara, Yousuke Nakai, Keisuke Tateishi, Kiyoshi Hasegawa, Tetsuo Ushiku and Mitsuhiro Fujishiro
- Organizer
  The 33rd Annual Meeting of the Asian Pacific Association for the Study of the Liver (APASL)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] TNFRSF14 and LIGHT are upregulated in biliary epithelia of patients with primary sclerosing cholangitis2023
- Author(s)
  Sachiko Kanai, Hiroaki Fujiwara, Suguru Mizuno, Takahiro Kishikawa, Yousuke Nakai, Keisuke Tateishi, and Mitsuhiro Fujishiro
- Organizer
  Digestive Disease Week 2023
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] Mutant IDH1 creates the tumorigenic precondition in biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2022
- Author(s)
  Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Yotaro Kudo, Kiyoshi Hasegawa, Tomoyoshi Soga, Kazuhiko Koike and Mitsuhiro Fujishiro
- Organizer
  Digestive Disease Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] Mutant IDH1 activates glycolysis in biliary epithelial cells through PFKP upregulation2022
- Author(s)
  Hiroaki Fujiwara, Keisuke Tateishi, Tomoyoshi Soga, Kazuhiko Koike and Mitsuhiro Fujishiro
- Organizer
  第81回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] Mutant IDH1 creates the tumorigenic precondition in biliary cells through PFKP-induced aerobic glycolysis and AMPK activationMutant IDH1 creates the tumorigenic precondition in biliary cells through PFKP-induced aerobic glycolysis and AMPK activationMutant IDH1 creates the tumorigenic precondition in biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2022
- Author(s)
  Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Yotaro Kudo, Kiyoshi Hasegawa, Tomoyoshi Soga, Kazuhiko Koike and Mitsuhiro Fujishiro
- Organizer
  Digestive Disease Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] 患者組織検体を用いた原発性硬化性胆管炎における特異的分子病態の探索2022
- Author(s)
  金井祥子、藤原弘明、藤城光弘
- Organizer
  第108回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] Mutant IDH1 creates the tumorigenic precondition in biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2022
- Author(s)
  Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Keisuke Yamamoto, Yotaro Kudo, Kiyoshi Hasegawa, Tomoyoshi Soga, Kazuhiko Koike and Mitsuhiro Fujishiro
- Organizer
  Digestive Disease Week 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] Interplay between metabolism and epigenetics in biliary epithelial cells induced by mutant IDH12022
- Author(s)
  Hiroaki Fujiwara
- Organizer
  アジア太平洋肝臓学会（APASL）Oncology 2022
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] 胆管癌における5-アミノレブリン酸を利用した光線力学的診断法の応用可能性2022
- Author(s)
  藤原弘明、高原楠昊、中井陽介、小池和彦、藤城光弘、立石敬介
- Organizer
  第43回日本臨床薬理学会学術総会
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] 患者組織検体を用いた原発性硬化性胆管炎における特異的分子病態の探索2022
- Author(s)
  金井祥子、藤原弘明、藤城光弘
- Organizer
  第108回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] 患者由来オルガノイドを用いた胆管癌診断における5-アミノレブリン酸の有用性の検討2021
- Author(s)
  藤原弘明、高原楠昊、小池和彦
- Organizer
  第107回日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] ヒト臨床検体由来オルガノイドを利用した、5-アミノレブリン酸による胆管癌の光線力学的診断の可能性についての検討2021
- Author(s)
  藤原弘明、高原楠昊、中井陽介、立石敬介、春日雅人、小池和彦
- Organizer
  第31回日本光線力学学会学術講演会
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] 患者由来オルガノイドを用いた胆道癌診断における5-アミノレブリン酸の有用性の検討2021
- Author(s)
  藤原弘明、高原楠昊、小池和彦
- Organizer
  第107回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] ヒト臨床検体由来オルガノイドを利用した、5-アミノレブリン酸による胆管癌の光線力学的診断の可能性についての検討2021
- Author(s)
  藤原弘明、高原楠昊、中井陽介、立石敬介、春日雅人、小池和彦
- Organizer
  第31回日本光線力学学会学術講演会
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] 患者由来オルガノイドを用いた胆道癌診断における5-アミノレブリン酸の有用性の検討2021
- Author(s)
  藤原弘明、高原楠昊、小池和彦
- Organizer
  第107回　日本消化器病学会総会
- Data Source
  KAKENHI-PROJECT-21K16012
[Presentation] Increased susceptibility to BET inhibition in IDH1-mutant intrahepatic cholangiocarcinoma.2019
- Author(s)
  Hiroaki Fujiwara, Keisuke Tateishi, Hiroyuki Kato, Takuma Nakatsuka, Yasuo Tanaka, Hideaki Ijichi, and Kazuhiko Koike
- Organizer
  Digestive Disease Week (DDW) 2019
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] 胆道癌ゲノム医療に向けたIDH変異陽性肝内胆管癌の標的分子に関する基礎的検討2019
- Author(s)
  藤原弘明、立石敬介、小池和彦
- Organizer
  第55回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17391
[Presentation] 肝内胆管上皮におけるIDH1変異の機能的役割2019
- Author(s)
  藤原弘明、三角健人、林玲匡、加藤裕之、中塚拓馬、田中康雄、伊地知秀明、深山正久、曽我朋義、小池和彦
- Organizer
  第56回日本臨床分子医学会学術集会
- Data Source
  KAKENHI-PROJECT-19K17391

1. TATEISHI KEISUKE (20396948)

# of Collaborated Projects: 3 results

# of Collaborated Products: 3 results
2. 水野卓 (30771050)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. 工藤洋太郎 (90608358)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. Kogure Hirofumi (60568921)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
5. Nakai Yousuke (80466755)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. 中塚拓馬 (50772042)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 金井祥子 (50931581)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. 早河翼 (60777655)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. TANAKA Yasuo

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 建石良介

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. 立花誠

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. 伊地知秀明

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. 高原楠昊

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJIWARA HIROAKI 藤原 弘明

Fujiwara Hiroaki 藤原 弘明

Research Projects

Research Products

Co-Researchers

代謝とエピゲノムを基軸とした肝内胆管発癌機構の解明と新規治療標的の探索Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Identification of pathogenesis and therapeutic targets in fontan-associated liver disease (FALD)

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

原発性硬化性胆管炎における分子生物学的基盤の解明

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

IDH変異陽性肝内胆管癌における特異的分子基盤の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive elucidation of intrahepatic biliary carcinogenesis induced by IDH mutationsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Comprehensive biological network analysis of pancreatic cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of metabolic reprogramming in intrahepatic cholangiocellular carcinoma

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of histone modification in patient-derived pancreatic cancer cells.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Book] Medical Practice2020

Author(s)

Total Pages

Publisher

Data Source

[Journal Article] Increased expression of TNFRSF14 and LIGHT in biliary epithelial cells of patients with primary sclerosing cholangitis2024

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Deletion of Histone Methyltransferase G9a Suppresses Mutant Kras-driven Pancreatic Carcinogenesis Carcinogenesis2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Soluble VCAM-1 promotes gemcitabine resistance via macrophage infiltration and predicts therapeutic response in pancreatic cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] 5-Aminolevulinic acid-mediated photodynamic activity in patient-derived cholangiocarcinoma organoids2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Mutant IDH1 confers resistance to energy stress in normal biliary cells through PFKP-induced aerobic glycolysis and AMPK activation2019

Author(s)

FUJIWARA HIROAKI 藤原弘明

Fujiwara Hiroaki 藤原弘明