Hirose Katsutoshi 廣瀬勝俊

Researcher Number	00824898
Other IDs	https://orcid.org/0000-0003-4148-1106
Affiliation (Current)	2025: 大阪大学, 大学院歯学研究科, 助教
Affiliation (based on the past Project Information) *help	2022 – 2024: 大阪大学, 大学院歯学研究科, 助教 2018 – 2021: 大阪大学, 歯学研究科, 助教
Review Section/Research Field	Principal Investigator Basic Section 57010:Oral biological science-related / Basic Section 57020:Oral pathobiological science-related / 0907:Oral science and related fields Except Principal Investigator Basic Section 57020:Oral pathobiological science-related / Basic Section 57070:Developmental dentistry-related / Basic Section 49020:Human pathology-related
Keywords	Principal Investigator 骨 / Fam20C / リン酸化 / 象牙質 / 酸性リン蛋白質 / DSPP / Dmp1 / 線維性異形成症 / GNAS / 象牙衛室 … More / トランスジェニックマウス / Dspp / リン酸化酵素 / DPP / 骨細胞 … More Except Principal Investigator 幹細胞 / 軟骨 / 線維性骨異形成症 / ホルモン補充療法 / 歯牙萌出不全 / 顎顔面形成不全 / 副甲状腺ホルモンシグナル / PIK3CA / TEK / 静脈奇形 / 脈管異常 / 空間トランスクリプトーム解析解析 / 体細胞モザイク / GNAS変異 / 再生医療 / 遺伝子多発性骨軟骨腫症 / 線維芽細胞 / 軟骨膜 / 創傷治癒 / ケロイド / 骨軟骨腫 / 細胞内ｃAMP / シングルセル解析 / 未分化間葉系幹細胞 / 機能亢進型GNAS変異疾患 / 骨髄間質細胞 / 細網線維 / シグナル伝達異常 / 骨髄間質幹細胞 / 機能亢進型GNAS変異 Less

体細胞モザイクである線維性骨異形成症のシングルセル解析による病態解明と創薬展開
- Principal Investigator
  
  豊澤悟
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
遺伝子異常に基づく静脈奇形の病態解明・新規治療法開発
- Principal Investigator
  
  廣瀬由美子 (堀由美子)
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  Osaka University
遺伝子異常に基づく機能亢進型GNAS変異疾患の根治的治療薬の探索Principal Investigator
- Principal Investigator
  
  廣瀬勝俊
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
高齢マウスの骨膜・軟骨膜内に存在する骨軟骨前駆細胞の同定と骨軟骨修復への利用
- Principal Investigator
  
  宇佐美悠
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
Development of a treatment method for maxillofacial dysplasia caused by parathyroid hormone (PTH) signaling disorder
- Principal Investigator
  
  黒坂寛
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57070:Developmental dentistry-related
- Research Institution
  Osaka University
Pathogenesis of fibrous dysplasia using hyperfunctional GNAS-mutant mice and drug discovery
- Principal Investigator
  
  Toyosawa Satoru
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
Osteo-chondro-progenitor cell in perichondrium: Identification and application for cartilage repair.
- Principal Investigator
  
  Usami Yu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 57020:Oral pathobiological science-related
- Research Institution
  Osaka University
Analysis of the role of Fam20C-mediated phosphorylation in mineralized tissues using Fam20C and Dmp1/Dspp overexpression micePrincipal Investigator
- Principal Investigator
  
  Hirose Katsutoshi
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Osaka University
The development of dentin formation-promoting peptides using odontoblast-specific Fam20C overexpression micePrincipal Investigator
- Principal Investigator
  
  Hirose Katsutoshi
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 57010:Oral biological science-related
- Research Institution
  Osaka University
象牙質形成おけるリン酸化修飾の意義Principal Investigator
- Principal Investigator
  
  廣瀬勝俊
- Project Period (FY)
  2018 – 2019
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Review Section
  
  0907:Oral science and related fields
- Research Institution
  Osaka University

All 2024 2023 2022 2021 2020 2019 2018

All Journal Article Presentation

[Journal Article] Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation2023
- Author(s)
  Naniwa Kohei、Hirose Katsutoshi、Usami Yu、Hata Kenji、Araki Rikita、Uzawa Narikazu、Komori Toshihisa、Toyosawa Satoru
- Journal Title
  
  Journal of Molecular Histology
  
  Volume: 54 Issue: 4 Pages: 329-347
- DOI
  10.1007/s10735-023-10123-y
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21K16930
[Journal Article] CRTC1-MAML2融合遺伝子を検出した石灰化を伴う舌下腺粘表皮癌の1例2022
- Author(s)
  奥村将, 宇佐美悠, 廣瀬勝俊, 大家香織, 福田康夫, 小原正治, 堀由美子, 森井英一, 豊澤悟
- Journal Title
  
  診断病理
  
  Volume: 39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19K18944
[Journal Article] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021
- Author(s)
  廣瀬勝俊, 豊澤悟
- Journal Title
  
  大阪大学歯学会雑誌
  
  Volume: 65 Pages: 1-3
- NAID
  120007177082
- Data Source
  KAKENHI-PROJECT-21K16930
[Journal Article] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021
- Author(s)
  廣瀬勝俊, 豊澤悟
- Journal Title
  
  大阪大学歯学会雑誌
  
  Volume: 65 Pages: 1-3
- NAID
  120007177082
- Data Source
  KAKENHI-PROJECT-19K18944
[Journal Article] Overexpression of Fam20C in osteoblast in vivo leads to increased cortical bone formation and osteoclastic bone resorption2020
- Author(s)
  Hirose Katsutoshi、Ishimoto Takuya、Usami Yu、Sato Sunao、Oya Kaori、Nakano Takayoshi、Komori Toshihisa、Toyosawa Satoru
- Journal Title
  
  Bone
  
  Volume: - Pages: 115414-115414
- DOI
  10.1016/j.bone.2020.115414
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17H04368, KAKENHI-PROJECT-19K18944
[Presentation] 遺伝子変異に基づいた骨疾患と血管疾患研究2024
- Author(s)
  廣瀬勝俊
- Organizer
  令和5年度岩垂育英会賞受賞者講演
- Invited
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα 構成的活性化が骨形成に及ぼす影響2024
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 芝原巧, 豊澤悟
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルマウスの解析2024
- Author(s)
  廣瀬勝俊, 兵頭美穂, 宇佐美悠, 芝原巧, 豊澤悟
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 皮膚創傷治癒における線維芽細胞へパラン硫酸鎖の役割2024
- Author(s)
  宇佐美悠, 寺本朱里, Li-Jie Li, 廣瀬勝俊, 豊澤悟
- Organizer
  第113回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21K09857
[Presentation] 線維性異形成症モデルマウスの検討：骨格系幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 豊澤悟
- Organizer
  歯科基礎医学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルの検討：LepR＋骨髄間質細胞におけるGsalpha構成的活性化が骨2023
- Author(s)
  豊澤悟、阿部真土、廣瀬勝俊、兵頭美穂、宇佐美悠、佐藤淳
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα;構成的活性化が骨形成に及ぼす影響2023
- Author(s)
  兵頭美穂、廣瀬勝俊、宇佐美悠、豊澤悟
- Organizer
  第112回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルマウス作製の試み2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 芝原巧, 宇佐美悠, 鵜澤成一, 豊澤悟
- Organizer
  日本臨床口腔病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性骨異形成症の病態解明を目指したモデルマウスの作製2023
- Author(s)
  兵頭美穂, 廣瀬勝俊, 宇佐美悠, 豊澤悟
- Organizer
  日本口腔科学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 新たな診断ツールとしての遺伝子パネル検査 -免疫染色のその先へ-2023
- Author(s)
  廣瀬勝俊
- Organizer
  第34回日本臨床口腔病理学会総会・学術大会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 線維性異形成症モデルの検討：骨髄間質幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2022
- Author(s)
  豊澤悟、阿部真土、廣瀬勝俊、宇佐美悠、佐藤淳
- Organizer
  第111回日本病理学会総会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] GNAS遺伝子変異マウスを用いたFibrous dysplasia の病態解析2022
- Author(s)
  兵頭美穂、廣瀬勝俊、宇佐美悠、豊澤悟
- Organizer
  第33回日本臨床口腔病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] Osteocytic constitutive activation of Gαs activity exerts an anabolic effect on the bone.2022
- Author(s)
  Hirose K, Naniwa K, Hyodo M, Usami Y, Abe M, Hata K, Inubushi T, Toyosawa S
- Organizer
  American Society for Bone and Mineral Research 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] 線維性異形成症モデルの検討: 骨髄間質幹細胞におけるGsα構成的活性化が骨形成に及ぼす影響2022
- Author(s)
  豊澤　悟、阿部真土、廣瀬勝俊、宇佐美悠、佐藤　淳
- Organizer
  日本病理学会
- Data Source
  KAKENHI-PROJECT-21H03110
[Presentation] Osteocytic constitutive activation of Gαs activity exerts an anabolic effect on the bone.2022
- Author(s)
  Katsutoshi Hirose, Kohei Naniwa, Miho Hyodo, Yu Usami, Makoto Abe, Kenji Hata, Toshihiro Inubushi, Satoru Toyosawa
- Organizer
  ASBMR 2022 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 象牙質形成におけるFam20Cによるリン酸化の役割について2022
- Author(s)
  浪花耕平、廣瀬勝俊、宇佐美悠、小守壽文、豊澤悟、青田桂子
- Organizer
  第58回日本口腔組織培養学会学術大会
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 骨細胞における Gsαの構成的活性化による骨格形成への影響2021
- Author(s)
  廣瀬勝俊, 浪花耕平, 宇佐美悠, 阿部真土, 豊澤悟
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] Fam20C overexpression in odontoblasts regulates dentin mineralization and odontoblast differentiation2021
- Author(s)
  Kohei Naniwa, Katsutoshi Hirose, Yu Usami, Toshihisa Komori, Satoru Toyosawa
- Organizer
  ASBMR 2021 Annual Meeting
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021
- Author(s)
  廣瀬勝俊
- Organizer
  大阪大学歯学会第67回総会第130回例会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] 骨細胞における Gsαの構成的活性化による骨格形成への影響2021
- Author(s)
  廣瀬勝俊, 浪花耕平, 宇佐美悠, 阿部真土, 豊澤悟
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] Fam20C の過剰発現は、歯冠象牙質の石灰化を促進し、歯根形成において象牙芽細胞の骨芽細胞への形質転換を誘導する2021
- Author(s)
  浪花耕平, 廣瀬勝俊, 宇佐美悠, 小守壽文, 豊澤悟
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] Fam20C の過剰発現は、歯冠象牙質の石灰化を促進し、歯根形成において象牙芽細胞の骨芽細胞への形質転換を誘導する2021
- Author(s)
  浪花耕平, 廣瀬勝俊, 宇佐美悠, 小守壽文, 豊澤悟
- Organizer
  第39回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021
- Author(s)
  廣瀬勝俊
- Organizer
  大阪大学歯学会第67回総会第130回例会
- Invited
- Data Source
  KAKENHI-PROJECT-21K16930
[Presentation] Fam20C overexpression in odontoblasts regulates dentin mineralization and odontoblast differentiation2021
- Author(s)
  Kohei Naniwa, Katsutoshi Hirose, Yu Usami, Toshihisa Komori, Satoru Toyosawa
- Organizer
  ASBMR 2021 Annual Meeting
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] 象牙質形成におけるFam20Cの役割2020
- Author(s)
  廣瀬勝俊, 浪花耕平, 宇佐美悠, 佐藤淳, 大家香織, 小守壽文, 豊澤悟
- Organizer
  第37回日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] Overexpression of Fam20C in odontoblasts leads to decreased dentin formation2020
- Author(s)
  浪花耕平, 廣瀬勝俊, 宇佐美悠, 白銀陽一郎, 奥村将, 小守壽文, 豊澤悟
- Organizer
  第62回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] 象牙質形成におけるゴルジ体キナーゼ Fam20C の役割について2020
- Author(s)
  浪花耕平, 廣瀬勝俊, 宇佐美悠, 大家香織, 佐藤淳, 小守壽文, 豊澤悟
- Organizer
  第61回歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] 象牙質形成におけるゴルジ体キナーゼ Fam20C の役割について2019
- Author(s)
  浪花耕平, 廣瀬勝俊, 宇佐美悠, 佐藤淳, 鵜澤成一, 豊澤悟
- Organizer
  第128回大阪大学歯学会
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] The role of Fam20C in dentin formation2019
- Author(s)
  Hirose K, Naniwa K, Usami Y, Oya K, Komori T, Toyosawa S
- Organizer
  American Society for Bone and Mineral Research annual meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K18944
[Presentation] 骨形成におけるゴルジ体キナーゼFam20Cの役割2018
- Author(s)
  廣瀬勝俊、宇佐美悠、佐藤淳、大家香織、社領美紀、小守壽文、豊澤悟
- Organizer
  第36回　日本骨代謝学会学術集会
- Data Source
  KAKENHI-PROJECT-18H06276
[Presentation] 骨形成におけるゴルジ体キナーゼFam20Cの役割2018
- Author(s)
  廣瀬勝俊、宇佐美悠、佐藤淳、大家香織、社領美紀、小守壽文、豊澤悟
- Organizer
  第60回　歯科基礎医学会学術大会
- Data Source
  KAKENHI-PROJECT-18H06276
[Presentation] The role of Fam20C in bone and tooth formation2018
- Author(s)
  Hirose K, Usami Y, Sato S, Sharyo M, Oya K, Komori T, Toyosawa S
- Organizer
  American Society for Bone and Mineral Research annual meeting 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H06276
[Presentation] 石灰化異常メカニズムの解明2018
- Author(s)
  廣瀬勝俊
- Organizer
  第107回　日本病理学会総会
- Data Source
  KAKENHI-PROJECT-18H06276

1. Usami Yu (80444579)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
2. Toyosawa Satoru (30243249)

# of Collaborated Projects: 3 results

# of Collaborated Products: 12 results
3. 鵜澤成一 (30345285)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
4. 阿部真土 (40448105)

# of Collaborated Projects: 2 results

# of Collaborated Products: 4 results
5. 廣瀬由美子 (60528785)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. 松井崇浩 (50747037)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. 犬伏俊博 (30550941)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 波多賢二 (80444496)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. 田熊一敞 (90289025)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 吉村信一郎 (60584521)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐藤淳 (70335660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 大家香織 (00779126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 山口雅也 (00714536)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 黒坂寛 (20509369)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 鈴木誠 (10533193)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 鹿島誠 (10780562)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 山城隆 (70294428)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 堀由美子

# of Collaborated Projects: 0 results

# of Collaborated Products: 11 results

Hirose Katsutoshi 廣瀬 勝俊

Research Projects

Research Products

Co-Researchers

体細胞モザイクである線維性骨異形成症のシングルセル解析による病態解明と創薬展開

Principal Investigator

Project Period (FY)

Research Category

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遺伝子異常に基づく静脈奇形の病態解明・新規治療法開発

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遺伝子異常に基づく機能亢進型GNAS変異疾患の根治的治療薬の探索Principal Investigator

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高齢マウスの骨膜・軟骨膜内に存在する骨軟骨前駆細胞の同定と骨軟骨修復への利用

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Development of a treatment method for maxillofacial dysplasia caused by parathyroid hormone (PTH) signaling disorder

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Pathogenesis of fibrous dysplasia using hyperfunctional GNAS-mutant mice and drug discovery

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Osteo-chondro-progenitor cell in perichondrium: Identification and application for cartilage repair.

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Analysis of the role of Fam20C-mediated phosphorylation in mineralized tissues using Fam20C and Dmp1/Dspp overexpression micePrincipal Investigator

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The development of dentin formation-promoting peptides using odontoblast-specific Fam20C overexpression micePrincipal Investigator

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象牙質形成おけるリン酸化修飾の意義Principal Investigator

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[Journal Article] Fam20C overexpression in odontoblasts regulates dentin formation and odontoblast differentiation2023

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[Journal Article] CRTC1-MAML2融合遺伝子を検出した石灰化を伴う舌下腺粘表皮癌の1例2022

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[Journal Article] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021

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NAID

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[Journal Article] 分泌型キナーゼFam20Cによるリン酸化を介した骨形成制御2021

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Hirose Katsutoshi 廣瀬勝俊

[Presentation] 線維性異形成症モデルの検討：骨格系幹細胞におけるGsα 構成的活性化が骨形成に及ぼす影響2024