Yamashita Kohei 山下晃平

Researcher Number	00867202
Other IDs
Affiliation (Current)	2025: 熊本大学, 病院, 特任助教
Affiliation (based on the past Project Information) *help	2025: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2021 – 2023: 熊本大学, 大学院生命科学研究部(医), 特定研究員 2021: 熊本大学, 大学, 特定研究員 2020 – 2021: 熊本大学, 病院, 非常勤診療医師
Review Section/Research Field	Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 50010:Tumor biology-related Except Principal Investigator Basic Section 55020:Digestive surgery-related / Basic Section 50010:Tumor biology-related
Keywords	Principal Investigator 胃癌 / 腫瘍免疫 / 癌性腹水 / 腹水 / 免疫微小環境 / サブクローン / 腫瘍免疫微小環境 / 腹膜播種 / NKG2A / 免疫チェックポイント分子 … More / Monalizumab / NKG2 / 可溶性HLA-E / HLA-E / NK細胞 … More Except Principal Investigator 腹膜播種 / 胃癌 / エキソソーム / microRNA / 細胞外マトリックス / SERPINE2 / 腹水 / 腫瘍微小環境 / 癌関連線維芽細胞 / NK細胞 / HLA-E / 免疫チェックポイント阻害剤 / heterogeneity / liquid biopsy Less

空間トランスクリプトーム解析による胃癌免疫治療抵抗性の解明Principal Investigator
- Principal Investigator
  
  山下晃平
- Project Period (FY)
  2025 – 2027
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kumamoto University
Deciphering the dynamic immune microenvironment in gastric cancer with peritoneal metastasis to identify novel Immunotherapeutic targets and biomarkersPrincipal Investigator
- Principal Investigator
  
  Yamashita Kohei
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Kumamoto University
Development of innovative therapies targeting tumor heterogeneity and tumor microenvironment in peritoneal dissemination of gastric cancer
- Principal Investigator
  
  Iwatsuki Masaaki
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University
Investigation of the cause of gastric cancer peritoneal dissemination by exosome-encapsulated microRNA/gene regulation
- Principal Investigator
  
  Kurashige Junji
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Kumamoto University
Analysis of regulatory mechanism of NKG2A / HLA-E pathway in gastric cancerPrincipal Investigator
- Principal Investigator
  
  Yamashita Kohei
- Project Period (FY)
  2020 – 2021
- Research Category
  
  Grant-in-Aid for Early-Career Scientists
- Review Section
  
  Basic Section 50010:Tumor biology-related
- Research Institution
  Kumamoto University

All 2022 2021 2020

All Journal Article Presentation

[Journal Article] Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia2022
- Author(s)
  Matsumoto Chihiro、Iwatsuki Masaaki、Iwagami Shiro、Morinaga Takeshi、Yamashita Kohei、Nakamura Kenichi、Eto Kojiro、Kurashige Junji、Baba Yoshifumi、Miyamoto Yuji、Yoshida Naoya、Komohara Yoshihiro、Baba Hideo
- Journal Title
  
  Gastric Cancer
  
  Volume: 25 Issue: 2 Pages: 473-478
- DOI
  10.1007/s10120-021-01253-x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09107
[Journal Article] Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer2022
- Author(s)
  Morinaga Takeshi、Iwatsuki Masaaki、Yamashita Kohei、Yasuda-Yoshihara Noriko、Yamane Taishi、Matsumoto Chihiro、Harada Kazuto、Eto Kojiro、Kurashige Junji、Ishimoto Takatsugu、Baba Yoshifumi、Miyamoto Yuji、Yoshida Naoya、Baba Hideo
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 30 Issue: 2 Pages: 1240-1252
- DOI
  10.1245/s10434-022-12505-0
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07594, KAKENHI-PROJECT-20K09107
[Journal Article] Evaluation of HLA-E Expression Combined with Natural Killer Cell Status as a Prognostic Factor for Advanced Gastric Cancer2022
- Author(s)
  Morinaga Takeshi、Iwatsuki Masaaki、Yamashita Kohei、Matsumoto Chihiro、Harada Kazuto、Kurashige Junji、Iwagami Shiro、Baba Yoshifumi、Yoshida Naoya、Komohara Yoshihiro、Baba Hideo
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: - Issue: 8 Pages: 4951-4960
- DOI
  10.1245/s10434-022-11665-3
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K16308, KAKENHI-PROJECT-20K07594, KAKENHI-PROJECT-20K09107
[Journal Article] ASO Visual Abstract: Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer2022
- Author(s)
  Morinaga Takeshi、Iwatsuki Masaaki、Yamashita Kohei、Yasuda-Yoshihara Noriko、Yamane Taishi、Matsumoto Chihiro、Harada Kazuto、Eto Kojiro、Kurashige Junji、Ishimoto Takatsugu、Baba Yoshifumi、Miyamoto Yuji、Yoshida Naoya、Baba Hideo
- Journal Title
  
  Annals of Surgical Oncology
  
  Volume: 30 Issue: 2 Pages: 1253-1254
- DOI
  10.1245/s10434-022-12555-4
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09107
[Journal Article] Evaluation of HLA-E expression combined with natural killer cell status as a prognostic factor for advanced gastric cancer2021
- Author(s)
  Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita, Chihiro Matsumoto, Kazuto Harada, Junji Kurashige, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Yoshihiro Komohara, Hideo Baba
- Journal Title
  
  Ann Surg Oncol
  
  Volume: -
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K07594
[Journal Article] Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer.2021
- Author(s)
  Yamashita K, Iwatsuki M, Yasuda-Yoshihara N, Morinaga T, Nakao Y, Harada K, Eto K, Kurashige J, Hiyoshi Y, Ishimoto T, Nagai Y, Iwagami S, Baba Y, Miyamoto Y, Yoshida N, Ajani JA, Baba H
- Journal Title
  
  Br J Cancer
  
  Volume: Feb;124(3) Pages: 595-603
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K07594
[Journal Article] Analysis of the survival and clinical characteristics of colorectal cancer patients with mental disorders2021
- Author(s)
  Kurashige Junji、Iwatsuki Masaaki、Mima Kosuke、Nomoto Daichi、Shigaki Hironobu、Yamashita Kohei、Morinaga Takeshi、Iwagami Shiro、Miyanari Nobutomo、Baba Hideo
- Journal Title
  
  Annals of Gastroenterological Surgery
  
  Volume: 5 Issue: 3 Pages: 314-320
- DOI
  10.1002/ags3.12421
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09107
[Journal Article] Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer2020
- Author(s)
  Yamashita Kohei、Iwatsuki Masaaki、Yasuda-Yoshihara Noriko、Morinaga Takeshi、Nakao Yosuke、Harada Kazuto、Eto Kojiro、Kurashige Junji、Hiyoshi Yukiharu、Ishimoto Takatsugu、Nagai Yohei、Iwagami Shiro、Baba Yoshifumi、Miyamoto Yuji、Yoshida Naoya、Ajani Jaffer A.、Baba Hideo
- Journal Title
  
  British Journal of Cancer
  
  Volume: 124 Issue: 3 Pages: 595-603
- DOI
  10.1038/s41416-020-01138-3
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K09107, KAKENHI-PROJECT-19K18095
[Journal Article] Oligometastatic recurrence as a prognostic factor after curative resection of esophageal squamous cell carcinoma2020
- Author(s)
  Morinaga Takeshi、Iwatsuki Masaaki、Yamashita Kohei、Harada Kazuto、Kurashige Junji、Nagai Yohei、Iwagami Shiro、Baba Yoshihumi、Yoshida Naoya、Baba Hideo
- Journal Title
  
  Surgery Today
  
  Volume: － Issue: 5 Pages: 798-806
- DOI
  10.1007/s00595-020-02173-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09107
[Journal Article] Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy2020
- Author(s)
  Kanemitsu Kosuke、Iwatsuki Masaaki、Yamashita Kohei、Komohara Yoshihiro、Morinaga Takeshi、Iwagami Shiro、Eto Kojiro、Nagai Yohei、Kurashige Junji、Baba Yoshifumi、Yoshida Naoya、Baba Hideo
- Journal Title
  
  Clinical Journal of Gastroenterology
  
  Volume: 14 Issue: 1 Pages: 92-97
- DOI
  10.1007/s12328-020-01290-6
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K09107
[Presentation] 胃癌におけるHLA-E発現制御機構とsoluble HLA-Eの臨床的意義の検討2022
- Author(s)
  森永剛司、岩槻政晃、山下晃平、山根大侍、松本千尋、江藤弘二郎、原田和人、岩上志朗、石本崇胤、馬場祥史、宮本裕士、吉田直矢、馬場秀夫
- Organizer
  第122回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K07594
[Presentation] 胃癌におけるHLA-E発現制御機構とsoluble HLA-Eの臨床的意義の検討2022
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、中村　健一、江藤　弘二郎、岩上　志朗、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第122回日本外科学会定期学術集
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] 胃癌におけるHLA-E発現制御機構とsoluble HLA-Eの臨床的意義の検討2022
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、中村　健一、江藤　弘二郎、岩上　志朗、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] Evaluation of HLA-E expression combined with natural killer cell status as a prognostic factor for advanced gastric cancer2021
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、中村　健一、江藤　弘二郎、岩上　志朗、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] Evaluation of HLA-E expression combined with natural killer cell status as a prognostic factor for advanced gastric cancer2021
- Author(s)
  Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita ,Kojiro Eto, Kazuto Harada, Junji Kurashige, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Yoshihiro Komohara, Hideo Baba
- Organizer
  第80回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K07594
[Presentation] 胃癌におけるHLA-E発現制御機構の解明2021
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、江藤　弘二郎、原田　和人、岩上　志朗、石本　崇胤、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第32回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-20K07594
[Presentation] The elucidation of regulatory mechanism of HLA-E expression in gastric cancer2021
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、中村　健一、江藤　弘二郎、岩上　志朗、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第32回日本消化器癌発生学会
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] The clinicopathological significance of HLA-E and NK expression in gastric cancer2021
- Author(s)
  Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita, Taishi Yamane, Tasuku Toihata, Kenichi Nakamura, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
- Organizer
  第76回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] The clinicopathological significance of HLA-E expression in advanced gastric cancer2020
- Author(s)
  Takeshi Morinaga, Masaaki Iwatsuki, Kohei Yamashita, Taishi Yamane, Tasuku Toihata, Kenichi Nakamura, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
- Organizer
  第79回日本癌学会学術総会
- Data Source
  KAKENHI-PROJECT-20K16308
[Presentation] 胃癌におけるPD-L1発現の空間的・時間的不均一性の検討2020
- Author(s)
  岩槻政晃、山下晃平、森永剛司、山根大侍、原田和人、江藤弘二郎、長井洋平、岩上志朗、吉田直矢、馬場秀夫
- Organizer
  第120回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-20K07594
[Presentation] 胃癌細胞におけるTrastuzumabが与えるPD-L1発現への影響2020
- Author(s)
  岩槻政晃、山下晃平、森永剛司、松本千尋、Lou mei yue、中村健一、岩上志朗、馬場祥史、吉田直矢、馬場秀夫
- Organizer
  第31回日本消化器癌発生学会総会
- Data Source
  KAKENHI-PROJECT-20K07594
[Presentation] 胃癌におけるHLA-E発現の臨床病理学的意義の検討2020
- Author(s)
  森永　剛司、岩槻　政晃、山下　晃平、山根　大侍、松本　千尋、中村　健一、江藤　弘二郎、岩上　志朗、馬場　祥史、宮本　裕士、吉田　直矢、馬場　秀夫
- Organizer
  第28回日本消化器関連学会週間/第18回日本消化器外科学会大会
- Data Source
  KAKENHI-PROJECT-20K16308

1. 原田和人 (70608869)

# of Collaborated Projects: 2 results

# of Collaborated Products: 10 results
2. Iwatsuki Masaaki (50452777)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. Kurashige Junji (90594474)

# of Collaborated Projects: 1 results

# of Collaborated Products: 6 results
4. 吉田直矢 (60467983)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
5. 江藤弘二郎 (40585717)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results

Yamashita Kohei 山下 晃平

Research Projects

Research Products

Co-Researchers

空間トランスクリプトーム解析による胃癌免疫治療抵抗性の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Deciphering the dynamic immune microenvironment in gastric cancer with peritoneal metastasis to identify novel Immunotherapeutic targets and biomarkersPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Development of innovative therapies targeting tumor heterogeneity and tumor microenvironment in peritoneal dissemination of gastric cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of the cause of gastric cancer peritoneal dissemination by exosome-encapsulated microRNA/gene regulation

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Analysis of regulatory mechanism of NKG2A / HLA-E pathway in gastric cancerPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Prophylactic laparoscopic total gastrectomy for gastric adenocarcinoma and proximal polyposis of the stomach (GAPPS): the first report in Asia2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of HLA-E Expression Combined with Natural Killer Cell Status as a Prognostic Factor for Advanced Gastric Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] ASO Visual Abstract: Dynamic Alteration in HLA-E Expression and Soluble HLA-E via Interaction with Natural Killer Cells in Gastric Cancer2022

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Evaluation of HLA-E expression combined with natural killer cell status as a prognostic factor for advanced gastric cancer2021

Author(s)

Journal Title

Data Source

[Journal Article] Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer.2021

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of the survival and clinical characteristics of colorectal cancer patients with mental disorders2021

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Trastuzumab upregulates programmed death ligand-1 expression through interaction with NK cells in gastric cancer2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Oligometastatic recurrence as a prognostic factor after curative resection of esophageal squamous cell carcinoma2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Two Asian families with gastric adenocarcinoma and proximal polyposis of the stomach successfully treated via laparoscopic total gastrectomy2020

Author(s)

Journal Title

Yamashita Kohei 山下晃平