TAKESHIGE Koichiro 竹重公一朗

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TAKESIGE Koichiro 竹重公一朗

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Researcher Number	10037450
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Affiliation (based on the past Project Information) *help	2006: Kyushu University, Faculty of Medical Sciences, Professor, 大学院医学研究院, 教授 2004 – 2006: 九州大学, 医学研究院, 教授 2003 – 2005: 九州大学, 大学院・医学研究院, 教授 2000: KYUSHU UNIVERSITY, Factory of Medicine, Prof., 大学院・医学研究院, 教授 1999: 九州大学, 大学院・医学系研究科, 教授 … More 1996 – 1998: 九州大学, 医学部, 教授 1993: Kyushu University, Biochemistry, Professor, 医学部, 教授 1986 – 1992: Kyushu Univ., Fac. Med., Assistant professor, 医学部, 助教授 Less
Review Section/Research Field	Principal Investigator Pathological medical chemistry / General medical chemistry / General medical chemistry / Functional biochemistry / Structural biochemistry Except Principal Investigator Pathological medical chemistry / General medical chemistry / Circulatory organs internal medicine / Functional biochemistry / 内科学一般
Keywords	Principal Investigator 活性酸素 / NADPHオキシダーゼ / 好中球 / IκB-ζ / シグナル伝達 / NADPH oxidase / Signal transduction / Superoxide / Active oxygens / スーパーオキサイド … More / Signaling / mRNA Stabilization / Regulation of Transcription / Innate Immunity / mRNA安定化 / 転写制御 / 自然免疫 / p40^<phox> / p67^<phox> / p47^<phox> / Rac / neurophils / active oxygens / superoxide / SH3ドメイン / 食細胞 / タンパク・タンパク相互作用 / シゲナル伝達 / タンパク質相互作用 / 細胞質因子p47 / Neutrophils / スーパーオキシド / 細胞障害 / 殺菌 / NADPHoxidase / Neurophils / リン脂質 / 細胞膜 / チトクロムb_<558> / ス-パ-オキサイド / GTP結合タンパク質 / NADPHオキシダ-ゼ / 複製 / ミトコンドリアDNA / 慢性肉芽腫症 / シトクロームb_<558> … More Except Principal Investigator 好中球 / 活性酸素 / ロイコトリエンB_4 / Superoxide / NADPHオキシダーゼ / Nuclear factor-κB (NF-κB) / IκB-ζ / p47-phox / gp91-phox / 慢性肉芽腫症 / カルシウム / 食作用 / チトクロムP_<450> / ミクロソ-ム / Cytochrome b_<558> / Phospholipid / Plasma membrane / NADPH oxidase / Neutrophils / チトクロム_558 / アラキドン酸 / グアニンヌクレオチド / チトクロムb558 / リン脂質 / 細胞膜 / ス-パ-オキサイド / NADPHオキシダ-ゼ / Ubiquinone / Cytochrome / NADPH-analog / HADPH-oxidase / Intracellular pH / Phagocytosis / モノクローン抗体 / ユビキノン / チトクローム / 超酸化物 / NADPH誘導体 / 細胞内pH変化 / Microcirculation / Rho-kinase / Cardiovascular diseases / Atherosclerosis / Nitric oxide / Hydrogen peroxide / Endothelium-derived hyperpolarizing factor / Endothelium-derived relaxing factors / eNOS欠損マウス / NOS欠損マウス / 内皮型NO合成酵素(eNOS) / 内皮由来弛緩因子 / 内皮由来過分極因子(EDHF) / 微小循環 / Rho-キナーゼ / 心血管病 / 動脈硬化 / 一酸化水素 / 過酸化水素 / 内皮由来過分極因子 / 内皮由来池緩因子 / Post-transcriptional regulation / Lipopolysaccharide (LPS) / Cytokine / Inflammation / Transcription / Innate immunity / Green Fluoresence Protein(GFP) / Green Fluorescence Protein (GFP) / アンキリンリピート / 核移行シグナル(NLS) / interleukin-6 (IL-6) / β-defensin / Nuclear Factor-κB (NF-κB) / 転写後修飾 / リポ多糖(LPS) / サイトカイン / 炎症 / 転写 / 自然免疫 / Nuclear factor-κB(NF-κB) / phagocyte / beta-actin / eosinophil / superoxide / neutrophil / Chronic granulomatous disease / 遺伝性疾患 / 細胞内アクチン異常症 / 白血球粘着不全症 / CGD / 高IgE症候群 / アポトーシス / β-アクチン / レトロウイルスベクター / シトクロム / 食細胞 / βアクチン / 好酸球 / ナトリウム / BCECF / H^+exchanger / Na^+ / ATP / 細胞内pH / 培養血管内皮細胞 / 顆粒内容放出 / タンパク質リン酸化反応 / 殺菌 / スーパーオキサイド / ロイコトリエン【B_4】 / 脂質過酸化反応 / ミトコンドリア / MPP^+ / MPTP / ω-水酸化反応 / チトクロムP-_<450> / ラット肝 Less

Studies on stimulus-specific induction of a novel NF-κB regulator, IκB-ζ, and its physiological rolesPrincipal Investigator
- Principal Investigator
  
  TAKESHIGE Koichiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KYUSHU UNIVERCITY
Experimental and Clinical Studies on the Significance of Endothelium-Derived Hyperpolarizing Factor (EDHF)
- Principal Investigator
  
  SHIMOKAWA Hiroaki
- Project Period (FY)
  2004 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Circulatory organs internal medicine
- Research Institution
  Tohoku University
  Kyushu University
Mechanisms for regulation of activation of innate immunity by a nuclear protein, IκB-ζ which functions in both acceleration and inhibition of transcription
- Principal Investigator
  
  MUTA Tatsushi
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Functional biochemistry
- Research Institution
  KYUSHU UNIVERSITY
ヒトミトコンドリアゲノム複製装置の分子機構―むだなDNA合成反応の解析―Principal Investigator
- Principal Investigator
  
  竹重公一朗
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Functional biochemistry
- Research Institution
  Kyushu University
細胞膜蛋白質複合体の活性化における立体構造変化を解析するPrincipal Investigator
- Principal Investigator
  
  竹重公一朗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Structural biochemistry
- Research Institution
  Kyushu University
Activation of the phagocyte NADPH oxidase and its disordersPrincipal Investigator
- Principal Investigator
  
  TAKESHIGE Koichiro
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  KYUSHU UNIVERSITY
Analysis of molecular mechanism of inherited phagocyte disorders.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Studies on the phagocyte-specific NADPH oxidase involving in the killing of micro organisms and cell damage and the mechanism of activationPrincipal Investigator
- Principal Investigator
  
  TAKESHIGE Koichiro, 水上茂樹
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
MPTPによるパ-キンソニズム発症の生化学的研究
- Principal Investigator
  
  水上茂樹
- Project Period (FY)
  1991
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
ロイコトリエンB_4のωー水酸化を行うチトクロ-ムPー450
- Principal Investigator
  
  水上茂樹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
多価不飽和脂肪酸による白血球機能の調節
- Principal Investigator
  
  水上茂樹
- Project Period (FY)
  1990
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
Studies on the production active oxygens by neutrophils and its regulation.Principal Investigator
- Principal Investigator
  
  TAKESIGE Koichiro
- Project Period (FY)
  1990 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  KYUSHU UNIVERSITY
多価不飽和脂肪酸による白血球機能の調節
- Principal Investigator
  
  MINAKAMI Shigeki
- Project Period (FY)
  1989
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyushu University
培養血管内皮細胞の刺激時における代謝変化に関する研究
- Principal Investigator
  
  水上茂樹
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyushu University
Purification and Characterization of Phagocyte NADPH Oxedase Participating in Bacterial Killing and Cell Damage
- Principal Investigator
  
  MINAKAMI Shigeki
- Project Period (FY)
  1987 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (A)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Kyushu University
食作用とカルシウム
- Principal Investigator
  
  水上茂樹
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Kyushu University
Phagocytosis-specific NADPH-oxidase and its Induction by Phagocytosis
- Principal Investigator
  
  MINAKAMI Shigeki
- Project Period (FY)
  1985 – 1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General medical chemistry
- Research Institution
  KYUSHU UNIVERSITY

All 2007 2006 2005 2004 2003

All Journal Article

[Journal Article] 誘導型NF-κB制御因子IκB-ζの研究2007
- Author(s)
  竹重公一朗
- Journal Title
  
  福岡医学会雑誌印刷中
- NAID
  120001219675
- Data Source
  KAKENHI-PROJECT-17590252
[Journal Article] 誘導型NF-κB制御因子IκB-ζの研究2007
- Author(s)
  竹重公一朗
- Journal Title
  
  福岡医学会雑誌 (印刷中)
- NAID
  120001219675
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590252
[Journal Article] A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy.2006
- Author(s)
  Hidaka, F., Matsuo, S., Muta, T., Takeshige, K., Mizukami, T., Nunoi, H.
- Journal Title
  
  Clin.Immunol. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] Positive and Negative Regulation of Nuclear Factor-κB-mediated Transcription by IκB-ζ, an Inducible Nuclear Protein.2005
- Author(s)
  Motoyama, M., Yamazaki, S., Eto-Kimura, A., Takeshige, K., Muta, T.
- Journal Title
  
  J.Biol.Chem. 280(9)
  
  Pages: 7444-7451
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] Stimulus-specific Induction of a Novel Nuclear Factor-κB Regulator, IκB-ζ, via Toll/Interleukin-1 Receptor Is Mediated by mRNA Stabilization.2005
- Author(s)
  Yamazaki, S., Muta, T., Matsuo, S., Takeshige, K.
- Journal Title
  
  J.Biol.Chem. 280(2)
  
  Pages: 1678-1687
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] The Amino-Terminal Region of Toll-like Receptor 4 is Essential for Binding to MD-2 and Receptor Translocation to the Cell Surface.2004
- Author(s)
  Fujimoto, T., Yamazaki, S., Eto-Kimura, A., Takeshige, K., Muta, T.
- Journal Title
  
  J.Biol.Chem. 279(46)
  
  Pages: 47431-47437
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] Regulation of Toll/IL-1 Receptor-mediated Gene Expression by the Inducible nuclear protein IκBζ.2004
- Author(s)
  Yamamoto, M., Yamazaki, S., Uematsu, S., Sato, S.Hemmi, H., Hoshino, K.Kaisho, T.Kuwata, H., Takeuchi, O., Takeshige, K., Saitoh, T., Yamaoka, S., Akira, S.
- Journal Title
  
  Nature 430(6996)
  
  Pages: 218-222
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] Purification and Characterization of Human Soluble CD14 Expressed in Pichia pastoris.2003
- Author(s)
  Nomura, S., Inamori, K., Muta, T.Yamazaki, S., Sunakawa, Y., Iwanaga, S., Takeshige, K.
- Journal Title
  
  Protein Expr.Purif. 28(2)
  
  Pages: 310-320
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059
[Journal Article] IκB-ζ, a New Anti-inflammatory Nuclear Protein Induced by Lipopolysaceharide, Is a Negative Regulator for Nuclear Factor-κB.2003
- Author(s)
  Muta, T., Yamazaki, S., Eto, A., Motoyama, M., Takeshige, K.
- Journal Title
  
  J.Endotoxin Res. 9(3)
  
  Pages: 187-191
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15370059

1. MINAKAMI Shigeki (90037325)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. SUMIMOTO Hideki (30179303)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
3. NANRI Hiroki (80150415)

# of Collaborated Projects: 6 results

# of Collaborated Products: 0 results
4. HINO Yukinobu (40112338)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. YAMASAKI Soh (70315084)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
6. MUTA Tatsushi (60222337)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
7. KANEGASAKI Shiro (10012767)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. NUNOI Hiroyuki (50218260)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KOMIYAMA Jun (50020798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. KITAGAWA Seiichi (50133278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. SENDO Fujiro (80091833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KOBAYASHI Kunihiko (60091451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. SHIMOKAWA Hiroaki (00235681)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. UTSUMI Hideo (20101694)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. AKAIKE Takaaki (20231798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. IBAYASHI Setsurou (40213201)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. HIROOKA Yoshitaka (90284497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 大石智也 (50038907)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 村井由之 (80038637)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 今野多助 (00004846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 小林陽之助 (50034062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 栗林太 (60251443)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 大場誠介 (80380666)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKESHIGE Koichiro 竹重 公一朗

TAKESIGE Koichiro 竹重 公一朗

Research Projects

Research Products

Co-Researchers

Studies on stimulus-specific induction of a novel NF-κB regulator, IκB-ζ, and its physiological rolesPrincipal Investigator

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Research Institution

Principal Investigator

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ヒトミトコンドリアゲノム複製装置の分子機構―むだなDNA合成反応の解析―Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

細胞膜蛋白質複合体の活性化における立体構造変化を解析するPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Activation of the phagocyte NADPH oxidase and its disordersPrincipal Investigator

Principal Investigator

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Research Field

Research Institution

Principal Investigator

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Research Category

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Research Institution

Studies on the phagocyte-specific NADPH oxidase involving in the killing of micro organisms and cell damage and the mechanism of activationPrincipal Investigator

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Research Field

Research Institution

Principal Investigator

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Principal Investigator

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Principal Investigator

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Studies on the production active oxygens by neutrophils and its regulation.Principal Investigator

Principal Investigator

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Research Category

Research Field

Research Institution

Principal Investigator

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Principal Investigator

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TAKESHIGE Koichiro 竹重公一朗

TAKESIGE Koichiro 竹重公一朗