Nunoi Hiroyuki 布井博幸

… Alternative Names

Researcher Number	50218260
Other IDs
External Links
Affiliation (Current)	2022: 宮崎大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2021: 宮崎大学, 医学部, 研究員 2018: 宮崎大学, 医学部, 元教授研究生 2004 – 2016: 宮崎大学, 医学部, 教授 2001 – 2002: 宮崎医科大学, 医学部, 教授 1998 – 2000: Kumamoto University, School of Med., Associate Professor, 医学部, 助教授 … More
Review Section/Research Field	Principal Investigator Pediatrics / 内科学一般 / 医学一般 / Pediatrics Except Principal Investigator Pediatrics / Clinical psychology / Bacteriology (including Mycology) / 内科学一般 / Structural biochemistry
Keywords	Principal Investigator 慢性肉芽腫症 / gp91-phox / 遺伝子治療 / PA317 / MFGS-gp91 / 遺伝子解析 / 病型分類 / Chronic Granulomatous Disease / pHa-MDR-IRES-gp91 / 293 SPA … More Except Principal Investigator 好中球 / スーパーオキシド / 慢性肉芽腫症 / CGD / 活性酸素 / シトクロム / Bリンパ球 / スーパーオキシドアニオン / HHV-6 / 発達障害 / ペアレント・トレーニング / p47-phox / レトロウイルスベクター / b型シトクロム / ホジキン病 / Tリンパ球 / 白血球 / 合成ペプチド / CD30 / チトクロームC / 急性脳症 / 急性脳炎 / サイトカイン / インフルエンザ / ロタウイルス / 炎症性サイトカイン / 乳幼児期 / 児童期 / 予防介入 / Super oxide / Neutrophils / gp91-phox / 食細胞 / superoxide / 遺伝子治療 / gene therapy / gp91 / p47 / p67 / 細胞質因子 / CD30陽性細胞 / リンパ腫 / 蛋白質リン酸化 / プロテインキナーゼC / 悪性リンパ腫 / マクロファージ / リンフォマトイド・パピュロ-シス / Bリンパ腫 / ALCL / Tリンパ腫 / ホジキソ病 / 新生児脳虚血性疾患 / インフルエンザ脳症・脳炎 / 血球貧食症候群 / 脳虚血性疾患 / 臓器移植 / 多臓器不全 / 血漿チトクローム / 小児感染症学 / ロタウィルス / チオレドキシン(TRX) / 酸化ストレス / インフルエンザ脳症 / 新型インフルエンザ / DNAマイクロアレイ / 単純ヘルペス / ロタウイルス脳炎・脳症 / 周産期睡眠リズム形成 / LD / AD/HD / ペアレントトレーニング / ADHD / 乳幼児 / 幼児 / 学童期 / 認知行動療法 / 行動療法 / 幼児期 / 早期介入 / 実行可能性 / 脳障害 / 乳幼児版ペアレント・トレーニング / 個別施行のペアレント・トレーニング / 周産期におけるリスクエピソード / 母親の虐待リスク / 愛着 / 早期診断 / 行動理論 / U937細胞 / 47kDa蛋白質 / 電気穿孔法 / Cytochrome / Synthetic peptides / NADPH / Phagocytes / 遺伝子 / ベクター / 慢性肉芽腫症患者 / インベ-ジン / ベェクター / リポソーム / b型のシトクロム / インベージン / p67-phox / B lymphocytes / Vector / Immunocompromised / 好酸球 / βアクチン / β-アクチン / アポトーシス / 高IgE症候群 / 白血球粘着不全症 / 細胞内アクチン異常症 / 遺伝性疾患 / Chronic granulomatous disease / neutrophil / eosinophil / beta-actin / phagocyte / 先天性異常 / B細胞 / 薬剤選択 / phagocytes / inherited disorder / B cell lines / retroviral vectors / cytochrome / MDR遺伝子 / 遺伝子導入 / MDR / B細胞株 / superoxide generation / retroviral vector / chronic granulomatous disease / MDR gene / 単純ヘルペスウイルス / インフルエンザウイルス / マイコプラズマ / 血管内皮細胞 / アデノウイルス / HHV6 / SSPE / SNPs / acute encephalitis / acute encephalopathy / influenza / rotavirus / pathogenesis / 思春期 / ティーチャートレーニング / ティーチャー・トレーニング / 周産期 / 遠隔介入 / 心理学的介入 / 二次障害への予防介入 / 二次障害への予防的介入 / 神経科学 / 子育て支援 Less

発達障害児への予防的介入システムの思春期への拡大と効果査定
- Principal Investigator
  
  立元真
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Development of PEG-DAO therapy in CGD micePrincipal Investigator
- Principal Investigator
  
  Nunoi Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Miyazaki
The early intervention system of Developmental Disorder
- Principal Investigator
  
  TATSUMOTO Shin
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention
- Principal Investigator
  
  MORISHIMA Tsuneo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
The Development of Early Diagnosis and Intervention System for Developmental Disorder Suspected Children
- Principal Investigator
  
  TATSUMOTO Shin
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Research on the pathogenesis, clinical features, diagnostic methods and treatment of acute encephalitis/encephalopathy.
- Principal Investigator
  
  MORISHIMA Tsuneo
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
急性疾患において医療行為のレベルを決定する初期検査としての血清中チトクロームC値
- Principal Investigator
  
  遠藤文夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
Analysis of the mutant β-actin functions in the mutant actin transduced mousePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  宮崎医科大学
A project of clinical application in a gene therapy for chronic granulomatous disease with gp91-phox deficiencyPrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Miyazaki Medical College
  Kumamoto University
Basic Study for Gene Therapy for the Patients with Chronic Granulomatous Disease -Construction of MND-gp91/PAM51-Principal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
悪性Tリンパ腫に発現したスーパーオキシド産生系の解析
- Principal Investigator
  
  金ヶさき士朗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Newly developed retrovirus for CGD gene-therapy : Cooperarive study of its effectiveness
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Preclinical studies of gene therapy for Chronic Granulomatous DiseasePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
A novel gene therapeutic strategy for chronic granulomatous disease.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
悪性リンパ腫におけるスーパーオキシド産生系の発現の解析
- Principal Investigator
  
  金ケ崎士朗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator
- Principal Investigator
  
  布井博幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of molecular mechanism of inherited phagocyte disorders.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator
- Principal Investigator
  
  布井博幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
悪性リンパ腫におけるスーパーオキシド産生系の解析とその発現の意義
- Principal Investigator
  
  金ヶ崎士朗
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
白血球スーパーオキシド産生系における蛋白質リン酸化の意義
- Principal Investigator
  
  大海忍
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
慢性内芽腫症の基礎的研究 b型シトクロムおよび細胞質因子欠損の遺伝生化学的解析
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Activation mechanism of superoxide generating system in neutrophils upon bacterial infection.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Restoration of superoxide generating ability to the cells derived from chronic granulomatous disease by protein or gene transfer.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Genetic analysis of Chronic Granulomatous Disease with cytosolic defect in JapanPrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  THE UNIVERSITY OF TOKYO
Analysis of the third cytosol factor involving in the neutrophil NADPH oxidasePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Kumamoto University

All 2016 2015 2005

All Journal Article Presentation

[Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為比較試験―2015
- Author(s)
  立元真，古川望子，鮫島浩，布井博幸，池ノ上克
- Journal Title
  
  行動療法研究
  
  Volume: 41 Pages: 127-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24330201
[Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為化比較試験―2015
- Author(s)
  立元真，古川望子，鮫島浩，布井博幸，池ノ上克
- Journal Title
  
  行動療法研究
  
  Volume: 41（2） Pages: 1-9
- NAID
  110009969917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24330201
[Journal Article] Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy.2005
- Author(s)
  Nunoi H, Mercado MR, et al.
- Journal Title
  
  Pediatr.Int. 47(2)
  
  Pages: 175-179
- NAID
  10016473876
- Data Source
  KAKENHI-PROJECT-17209037
[Presentation] CGD登録事業から学んだこと2016
- Author(s)
  布井博幸
- Organizer
  食細胞機能異常研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-16K09972
[Presentation] Clinical and Genetic Profiles of Chronic Granulomatous Disease in Japan2016
- Author(s)
  Tomoyuki Mizukami, Mayumi Iwata-Okada, Toyoki Nishimura,Hiroyuki Nunoi et al
- Organizer
  European Society of Immuno Deficiency
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09972

1. KANEGASAKI Shiro (10012767)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. KOBAYASHI Sonoko (00013764)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. IMAJOH-OHMI Shinobu (20160046)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. KURIBAYASHI Futoshi (60251443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TATSUMOTO Shin (50279965)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. SAMESHIMA Hiroshi (50274775)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. KIMURA Hioroshi (30303621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TOGASAKI Yasuko (40300040)

# of Collaborated Projects: 2 results

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9. MORISHIMA Tsuneo (90157892)

# of Collaborated Projects: 2 results

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10. OKABE Nobuhiko (10057028)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. ICHIYAMA Takashi (20263767)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SATO Shoji (30107205)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 武井優子 (00727886)

# of Collaborated Projects: 2 results

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14. Maeda Hiroshi (90004613)

# of Collaborated Projects: 2 results

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15. 松本良二 (20272495)

# of Collaborated Projects: 2 results

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16. 児玉由紀 (30305081)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
17. NAKAGOMI Osamu (70143047)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KONDOU Kazuhiro (70234929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HOSOYA Mitsuaki (80192318)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. MATSUKAWA Akihiro (90264283)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. YOSHIKAWA Tetsushi (80288472)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. OKUMURA Akihisa (60303624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IKENOUE Tuyomu (60232211)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. SATO Youko (50196284)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. ISHIKAWA Shinichi (90404392)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. OGATA Akiko (70452919)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. ONO Yasuo (10177272)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. KOMIYAMA Jun (50020798)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. KITAGAWA Seiichi (50133278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SENDO Fujiro (80091833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. KOBAYASHI Kunihiko (60091451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. MIZUGUCHI Masashi (20209753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 遠藤文夫 (00176801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 足立尚登 (00264292)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 児玉由紀 (30305031)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 今野多助 (00004846)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 竹重公一朗 (10037450)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 小林陽之助 (50034062)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 松倉誠 (70238997)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 前田泰弘 (10337206)

# of Collaborated Projects: 1 results

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41. 石田康 (20212897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. 湯田拓史 (20448161)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
43. 尾之上高哉 (30631775)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
44. 金子政時 (40264387)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
45. 境泉洋 (90399220)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
46. 大平洋明 (10806269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
47. MALY Friedrich

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. DINAUER Mary C.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
49. MALECH Harry

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
50. FRIERICH Ern

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
51. DINAUER Marr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 島津光伸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Nunoi Hiroyuki 布井 博幸

NUNOI Hiroyuki 布井 博幸

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Development of PEG-DAO therapy in CGD micePrincipal Investigator

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Analysis of the mutant β-actin functions in the mutant actin transduced mousePrincipal Investigator

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A project of clinical application in a gene therapy for chronic granulomatous disease with gp91-phox deficiencyPrincipal Investigator

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Basic Study for Gene Therapy for the Patients with Chronic Granulomatous Disease -Construction of MND-gp91/PAM51-Principal Investigator

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Preclinical studies of gene therapy for Chronic Granulomatous DiseasePrincipal Investigator

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Nunoi Hiroyuki 布井博幸

NUNOI Hiroyuki 布井博幸