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Nunoi Hiroyuki  布井 博幸

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… Alternative Names

NUNOI Hiroyuki  布井 博幸

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Researcher Number 50218260
Other IDs
External Links
Affiliation (Current) 2020: 宮崎大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help 2017 – 2020: 宮崎大学, 医学部, 研究員
2018: 宮崎大学, 医学部, 元教授 研究生
2004 – 2016: 宮崎大学, 医学部, 教授
2001 – 2002: 宮崎医科大学, 医学部, 教授
1998 – 2000: Kumamoto University, School of Med., Associate Professor, 医学部, 助教授 … More
1997: Kumamoto Univ.Sch.of Med.Instructor, 医学部, 講師
1993 – 1996: 東京大学, 医科学研究所, 助手
1994: 医科学研究所, 助手
1991 – 1992: 熊本大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Pediatrics / 内科学一般 / 医学一般 / Pediatrics
Except Principal Investigator
Pediatrics / Clinical psychology / Bacteriology (including Mycology) / 内科学一般 / Structural biochemistry
Keywords
Principal Investigator
慢性肉芽腫症 / gp91-phox / 遺伝子治療 / PA317 / MFGS-gp91 / 遺伝子解析 / 病型分類 / Chronic Granulomatous Disease / pHa-MDR-IRES-gp91 / 293 SPA … More / MND-gp91 / 293 / SPA / gene therapy / Retrovirus Vector / スーパーオキサイド産生酵素 / 細胞質因子 / 低分子G蛋白 / ス-パ-オキサイド産生酵素 / 細胞室因子 / Chronic Granulomatous Disease (CGD) / NADPH oxidase / Small G Protein (rac1 / 2) / p47-phox / p67-phox / 好中球 / 統計 / 病型分類と統計 / 常染色体劣性遺伝 / P47細胞質蛋白 / p67細胞質蛋白 / Neutrophile / Molecular analysis / Classification of the disease / Statistics of the disease / レトロウイルスベクター / レトロウイルス・ベクター / Ha-MDR-IRES-gp91 / 293SPA / レトロウィルス・ベクター / retrovirus vector / PAM51 / IFN-g / PAMP51 レトルウイルス・ベクター / PA317 レトルウイルス・ベクター / SPA レトルウイルス・ベクター / 慢性肉芽腫症遺伝子治療 / MIND-gp91ベクター / Ha-MDR-IRES-gp91ベクター / 239・SPAベクター / PAMP51 / INF-γ / Ha-MDR-IRES-gp91retrovirus / in vivo selection / p40phox / D289A変異 / K355A変異 / インターフェロンγ / MND-gp91-phox遺伝子治療ベクター / MFGS-gp91ベクター / gp91ノックアウト・マウス / Chronic granulomatous disease / p40-phox / Nox family / p41nox / p51nox / 好中球細胞骨格異常症 / 変異β-アクチン / 変異β-アクチンKnock-In Mouse / 変異β-アクチン遺伝子導入細胞 / 変異β-アクチンKnoch-In Mouse / mutantβ-actin / knock-in mouse / neutrophil cytoskeletal disease / Nox5 / p41rox / p5lnox / PEG-ADO酵素補充療法 / CGDマウス / カンジダ死菌誘発性肺炎 / D型アミノ酸 / カンジダ死菌による肺炎実験 / PEG-DAO / D-amino acid / PEG-DAO酵素補充療法 / カンジダ死菌による肺肉芽腫症 / カンジダ死菌による肉芽腫モデル / 酵素補充療法 … More
Except Principal Investigator
好中球 / スーパーオキシド / 慢性肉芽腫症 / CGD / 活性酸素 / シトクロム / Bリンパ球 / スーパーオキシドアニオン / HHV-6 / 発達障害 / ペアレント・トレーニング / p47-phox / レトロウイルスベクター / b型シトクロム / ホジキン病 / Tリンパ球 / 白血球 / 合成ペプチド / CD30 / チトクロームC / 急性脳症 / 急性脳炎 / サイトカイン / インフルエンザ / ロタウイルス / 炎症性サイトカイン / 乳幼児期 / 児童期 / 予防介入 / Super oxide / Neutrophils / gp91-phox / 食細胞 / superoxide / 遺伝子治療 / gene therapy / gp91 / p47 / p67 / 細胞質因子 / CD30陽性細胞 / リンパ腫 / 蛋白質リン酸化 / プロテインキナーゼC / 悪性リンパ腫 / マクロファージ / リンフォマトイド・パピュロ-シス / Bリンパ腫 / ALCL / Tリンパ腫 / ホジキソ病 / 新生児脳虚血性疾患 / インフルエンザ脳症・脳炎 / 血球貧食症候群 / 脳虚血性疾患 / 臓器移植 / 多臓器不全 / 血漿チトクローム / 小児感染症学 / ロタウィルス / チオレドキシン(TRX) / 酸化ストレス / インフルエンザ脳症 / 新型インフルエンザ / DNAマイクロアレイ / 単純ヘルペス / ロタウイルス脳炎・脳症 / 周産期睡眠リズム形成 / LD / AD/HD / ペアレントトレーニング / ADHD / 乳幼児 / 幼児 / 学童期 / 認知行動療法 / 行動療法 / 幼児期 / 早期介入 / 実行可能性 / 脳障害 / 乳幼児版ペアレント・トレーニング / 個別施行のペアレント・トレーニング / 周産期におけるリスクエピソード / 母親の虐待リスク / 愛着 / 早期診断 / 行動理論 / U937細胞 / 47kDa蛋白質 / 電気穿孔法 / Cytochrome / Synthetic peptides / NADPH / Phagocytes / 遺伝子 / ベクター / 慢性肉芽腫症患者 / インベ-ジン / ベェクター / リポソーム / b型のシトクロム / インベージン / p67-phox / B lymphocytes / Vector / Immunocompromised / 好酸球 / βアクチン / β-アクチン / アポトーシス / 高IgE症候群 / 白血球粘着不全症 / 細胞内アクチン異常症 / 遺伝性疾患 / Chronic granulomatous disease / neutrophil / eosinophil / beta-actin / phagocyte / 先天性異常 / B細胞 / 薬剤選択 / phagocytes / inherited disorder / B cell lines / retroviral vectors / cytochrome / MDR遺伝子 / 遺伝子導入 / MDR / B細胞株 / superoxide generation / retroviral vector / chronic granulomatous disease / MDR gene / 単純ヘルペスウイルス / インフルエンザウイルス / マイコプラズマ / 血管内皮細胞 / アデノウイルス / HHV6 / SSPE / SNPs / acute encephalitis / acute encephalopathy / influenza / rotavirus / pathogenesis / 思春期 / ティーチャートレーニング / 心理学的介入 / 二次障害への予防介入 / ティーチャー・トレーニング / 周産期 / 二次障害への予防的介入 / 神経科学 / 子育て支援 Less
  • Research Projects

    (25 results)
  • Research Products

    (5 results)
  • Co-Researchers

    (51 People)
  •  発達障害児への予防的介入システムの思春期への拡大と効果査定Ongoing

    • Principal Investigator
      立元 真
    • Project Period (FY)
      2017 – 2021
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Clinical psychology
    • Research Institution
      University of Miyazaki
  •  Development of PEG-DAO therapy in CGD micePrincipal Investigator

    • Principal Investigator
      Nunoi Hiroyuki
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      University of Miyazaki
  •  The early intervention system of Developmental Disorder

    • Principal Investigator
      TATSUMOTO Shin
    • Project Period (FY)
      2012 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Clinical psychology
    • Research Institution
      University of Miyazaki
  •  Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention

    • Principal Investigator
      MORISHIMA Tsuneo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Okayama University
  •  The Development of Early Diagnosis and Intervention System for Developmental Disorder Suspected Children

    • Principal Investigator
      TATSUMOTO Shin
    • Project Period (FY)
      2008 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Clinical psychology
    • Research Institution
      University of Miyazaki
  •  Research on the pathogenesis, clinical features, diagnostic methods and treatment of acute encephalitis/encephalopathy.

    • Principal Investigator
      MORISHIMA Tsuneo
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Pediatrics
    • Research Institution
      Okayama University
  •  急性疾患において医療行為のレベルを決定する初期検査としての血清中チトクロームC値

    • Principal Investigator
      遠藤 文夫
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Pediatrics
    • Research Institution
      Kumamoto University
  •  Analysis of the mutant β-actin functions in the mutant actin transduced mousePrincipal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      宮崎医科大学
  •  A project of clinical application in a gene therapy for chronic granulomatous disease with gp91-phox deficiencyPrincipal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Miyazaki Medical College
      Kumamoto University
  •  Basic Study for Gene Therapy for the Patients with Chronic Granulomatous Disease -Construction of MND-gp91/PAM51-Principal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Kumamoto University
  •  悪性Tリンパ腫に発現したスーパーオキシド産生系の解析

    • Principal Investigator
      金ヶさき 士朗
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Newly developed retrovirus for CGD gene-therapy : Cooperarive study of its effectiveness

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      The University of Tokyo
  •  Preclinical studies of gene therapy for Chronic Granulomatous DiseasePrincipal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Pediatrics
    • Research Institution
      Kumamoto University
  •  A novel gene therapeutic strategy for chronic granulomatous disease.

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  悪性リンパ腫におけるスーパーオキシド産生系の発現の解析

    • Principal Investigator
      金ケ崎 士朗
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator

    • Principal Investigator
      布井 博幸
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  Analysis of molecular mechanism of inherited phagocyte disorders.

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1996 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator

    • Principal Investigator
      布井 博幸
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      The University of Tokyo
  •  悪性リンパ腫におけるスーパーオキシド産生系の解析とその発現の意義

    • Principal Investigator
      金ヶ崎 士朗
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  白血球スーパーオキシド産生系における蛋白質リン酸化の意義

    • Principal Investigator
      大海 忍
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Structural biochemistry
    • Research Institution
      The University of Tokyo
  •  慢性内芽腫症の基礎的研究 b型シトクロムおよび細胞質因子欠損の遺伝生化学的解析

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Activation mechanism of superoxide generating system in neutrophils upon bacterial infection.

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      The University of Tokyo
  •  Restoration of superoxide generating ability to the cells derived from chronic granulomatous disease by protein or gene transfer.

    • Principal Investigator
      KANEGASAKI Shiro
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for Developmental Scientific Research (B)
    • Research Field
      Bacteriology (including Mycology)
    • Research Institution
      The University of Tokyo
  •  Genetic analysis of Chronic Granulomatous Disease with cytosolic defect in JapanPrincipal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      内科学一般
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  Analysis of the third cytosol factor involving in the neutrophil NADPH oxidasePrincipal Investigator

    • Principal Investigator
      NUNOI Hiroyuki
    • Project Period (FY)
      1991 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      医学一般
    • Research Institution
      Kumamoto University

All 2016 2015 2005

All Journal Article Presentation

  • [Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為化比較試験―2015

    • Author(s)
      立元真,古川望子,鮫島浩,布井博幸,池ノ上克
    • Journal Title

      行動療法研究

      Volume: 41(2) Pages: 1-9

    • NAID

      110009969917

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-24330201
  • [Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為 比較試験―2015

    • Author(s)
      立元真,古川望子,鮫島浩,布井博幸,池ノ上克
    • Journal Title

      行動療法研究

      Volume: 41 Pages: 127-135

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24330201
  • [Journal Article] Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy.2005

    • Author(s)
      Nunoi H, Mercado MR, et al.
    • Journal Title

      Pediatr.Int. 47(2)

      Pages: 175-179

    • NAID

      10016473876

    • Data Source
      KAKENHI-PROJECT-17209037
  • [Presentation] CGD登録事業から学んだこと2016

    • Author(s)
      布井博幸
    • Organizer
      食細胞機能異常研究会
    • Place of Presentation
      東京
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K09972
  • [Presentation] Clinical and Genetic Profiles of Chronic Granulomatous Disease in Japan2016

    • Author(s)
      Tomoyuki Mizukami, Mayumi Iwata-Okada, Toyoki Nishimura,Hiroyuki Nunoi et al
    • Organizer
      European Society of Immuno Deficiency
    • Place of Presentation
      Barcelona, Spain
    • Year and Date
      2016-09-21
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K09972
  • 1.  KANEGASAKI Shiro (10012767)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 2.  KOBAYASHI Sonoko (00013764)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 3.  IMAJOH-OHMI Shinobu (20160046)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  KURIBAYASHI Futoshi (60251443)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 5.  TATSUMOTO Shin (50279965)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 6.  SAMESHIMA Hiroshi (50274775)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 2 results
  • 7.  KIMURA Hioroshi (30303621)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  TOGASAKI Yasuko (40300040)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MORISHIMA Tsuneo (90157892)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  OKABE Nobuhiko (10057028)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 11.  ICHIYAMA Takashi (20263767)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 12.  SATO Shoji (30107205)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 13.  武井 優子 (00727886)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 14.  Maeda Hiroshi (90004613)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 15.  松本 良二 (20272495)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 16.  児玉 由紀 (30305081)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 17.  NAKAGOMI Osamu (70143047)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KONDOU Kazuhiro (70234929)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  HOSOYA Mitsuaki (80192318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  MATSUKAWA Akihiro (90264283)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  YOSHIKAWA Tetsushi (80288472)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  OKUMURA Akihisa (60303624)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 23.  IKENOUE Tuyomu (60232211)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  SATO Youko (50196284)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  ISHIKAWA Shinichi (90404392)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  OGATA Akiko (70452919)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  ONO Yasuo (10177272)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  KOMIYAMA Jun (50020798)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KITAGAWA Seiichi (50133278)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  SENDO Fujiro (80091833)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  KOBAYASHI Kunihiko (60091451)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  MIZUGUCHI Masashi (20209753)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  遠藤 文夫 (00176801)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  足立 尚登 (00264292)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  児玉 由紀 (30305031)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  今野 多助 (00004846)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  竹重 公一朗 (10037450)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  小林 陽之助 (50034062)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  松倉 誠 (70238997)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  前田 泰弘 (10337206)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  石田 康 (20212897)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  湯田 拓史 (20448161)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  尾之上 高哉 (30631775)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 44.  金子 政時 (40264387)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 45.  境 泉洋 (90399220)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  MALY Friedrich
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  DINAUER Mary C.
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  MALECH Harry
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  FRIERICH Ern
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  DINAUER Marr
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 51.  島津 光伸
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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