Nunoi Hiroyuki 布井博幸

… Alternative Names

NUNOI Hiroyuki 布井博幸

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Researcher Number	50218260
Other IDs
External Links
Affiliation (Current)	2025: 宮崎大学, 医学部, 研究員
Affiliation (based on the past Project Information) *help	2017 – 2022: 宮崎大学, 医学部, 研究員 2018: 宮崎大学, 医学部, 元教授研究生 2004 – 2016: 宮崎大学, 医学部, 教授 2001 – 2002: 宮崎医科大学, 医学部, 教授 1998 – 2000: Kumamoto University, School of Med., Associate Professor, 医学部, 助教授 … More 1997: Kumamoto Univ.Sch.of Med.Instructor, 医学部, 講師 1993 – 1996: 東京大学, 医科学研究所, 助手 1994: 医科学研究所, 助手 1991 – 1992: 熊本大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Pediatrics / 内科学一般 / Pediatrics / 医学一般 Except Principal Investigator Bacteriology (including Mycology) / Clinical psychology / Pediatrics / 内科学一般 / Structural biochemistry
Keywords	Principal Investigator gp91-phox / 慢性肉芽腫症 / 遺伝子治療 / MFGS-gp91 / PA317 / 病型分類 / 遺伝子解析 / gene therapy / SPA / 293 … More / MND-gp91 / 293 SPA / pHa-MDR-IRES-gp91 / Chronic Granulomatous Disease / 酵素補充療法 / カンジダ死菌による肉芽腫モデル / カンジダ死菌による肺肉芽腫症 / D-amino acid / PEG-DAO / カンジダ死菌による肺炎実験 / D型アミノ酸 / カンジダ死菌誘発性肺炎 / CGDマウス / PEG-DAO酵素補充療法 / p5lnox / p41rox / Nox5 / neutrophil cytoskeletal disease / knock-in mouse / mutantβ-actin / 変異β-アクチンKnoch-In Mouse / 変異β-アクチン遺伝子導入細胞 / 変異β-アクチンKnock-In Mouse / 変異β-アクチン / 好中球細胞骨格異常症 / p51nox / p41nox / Nox family / p40-phox / Chronic granulomatous disease / gp91ノックアウト・マウス / MFGS-gp91ベクター / MND-gp91-phox遺伝子治療ベクター / インターフェロンγ / K355A変異 / D289A変異 / p40phox / in vivo selection / Ha-MDR-IRES-gp91retrovirus / INF-γ / PAMP51 / 239・SPAベクター / Ha-MDR-IRES-gp91ベクター / MIND-gp91ベクター / 慢性肉芽腫症遺伝子治療 / SPA レトルウイルス・ベクター / PA317 レトルウイルス・ベクター / PAMP51 レトルウイルス・ベクター / IFN-g / PAM51 / retrovirus vector / レトロウィルス・ベクター / 293SPA / Ha-MDR-IRES-gp91 / レトロウイルス・ベクター / レトロウイルスベクター / Statistics of the disease / Classification of the disease / Molecular analysis / Neutrophile / p67細胞質蛋白 / P47細胞質蛋白 / 常染色体劣性遺伝 / 病型分類と統計 / 統計 / 好中球 / p67-phox / p47-phox / 2) / Small G Protein (rac1 / NADPH oxidase / Chronic Granulomatous Disease (CGD) / 細胞室因子 / ス-パ-オキサイド産生酵素 / 低分子G蛋白 / 細胞質因子 / スーパーオキサイド産生酵素 / Retrovirus Vector … More Except Principal Investigator 好中球 / スーパーオキシド / CGD / 慢性肉芽腫症 / シトクロム / 活性酸素 / レトロウイルスベクター / p47-phox / ペアレント・トレーニング / 発達障害 / HHV-6 / スーパーオキシドアニオン / Bリンパ球 / p67 / p47 / gp91 / gene therapy / 遺伝子治療 / superoxide / 食細胞 / gp91-phox / Neutrophils / Super oxide / 予防介入 / 児童期 / 乳幼児期 / 炎症性サイトカイン / ロタウイルス / インフルエンザ / サイトカイン / 急性脳炎 / 急性脳症 / チトクロームC / CD30 / 合成ペプチド / 白血球 / Tリンパ球 / ホジキン病 / b型シトクロム / 子育て支援 / 神経科学 / 二次障害への予防的介入 / 二次障害への予防介入 / 心理学的介入 / 遠隔介入 / ティーチャートレーニング / 思春期 / 周産期 / ティーチャー・トレーニング / pathogenesis / rotavirus / influenza / acute encephalopathy / acute encephalitis / SNPs / SSPE / HHV6 / アデノウイルス / 血管内皮細胞 / マイコプラズマ / インフルエンザウイルス / 単純ヘルペスウイルス / MDR gene / chronic granulomatous disease / retroviral vector / superoxide generation / B細胞株 / MDR / 遺伝子導入 / MDR遺伝子 / cytochrome / retroviral vectors / B cell lines / inherited disorder / phagocytes / 薬剤選択 / B細胞 / 先天性異常 / phagocyte / beta-actin / eosinophil / neutrophil / Chronic granulomatous disease / 遺伝性疾患 / 細胞内アクチン異常症 / 白血球粘着不全症 / 高IgE症候群 / アポトーシス / β-アクチン / βアクチン / 好酸球 / Immunocompromised / Vector / B lymphocytes / p67-phox / インベージン / b型のシトクロム / リポソーム / ベェクター / インベ-ジン / 慢性肉芽腫症患者 / ベクター / 遺伝子 / Phagocytes / NADPH / Synthetic peptides / Cytochrome / 電気穿孔法 / 47kDa蛋白質 / U937細胞 / 行動理論 / 早期診断 / 愛着 / 母親の虐待リスク / 周産期におけるリスクエピソード / 個別施行のペアレント・トレーニング / 乳幼児版ペアレント・トレーニング / 脳障害 / 実行可能性 / 早期介入 / 幼児期 / 行動療法 / 認知行動療法 / 学童期 / 幼児 / 乳幼児 / ADHD / ペアレントトレーニング / AD/HD / LD / 周産期睡眠リズム形成 / ロタウイルス脳炎・脳症 / 単純ヘルペス / DNAマイクロアレイ / 新型インフルエンザ / インフルエンザ脳症 / 酸化ストレス / チオレドキシン(TRX) / ロタウィルス / 小児感染症学 / 血漿チトクローム / 多臓器不全 / 臓器移植 / 脳虚血性疾患 / 血球貧食症候群 / インフルエンザ脳症・脳炎 / 新生児脳虚血性疾患 / ホジキソ病 / Tリンパ腫 / ALCL / Bリンパ腫 / リンフォマトイド・パピュロ-シス / マクロファージ / 悪性リンパ腫 / プロテインキナーゼC / 蛋白質リン酸化 / リンパ腫 / CD30陽性細胞 / 細胞質因子 Less

Expansion and effect inspection to the puberty of the preventive intervention system to the children with developmental with a disability.
- Principal Investigator
  
  Tatsumoto Shin
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Treatment with Polyethylene Glycol-Conjugated Fungal d-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous DiseasePrincipal Investigator
- Principal Investigator
  
  Nunoi Hiroyuki
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  University of Miyazaki
The early intervention system of Developmental Disorder
- Principal Investigator
  
  TATSUMOTO Shin
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Study on the pathogenesis of acute encephalitis and encephalopathy for the effective treatment and prevention
- Principal Investigator
  
  MORISHIMA Tsuneo
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
The Development of Early Diagnosis and Intervention System for Developmental Disorder Suspected Children
- Principal Investigator
  
  TATSUMOTO Shin
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Clinical psychology
- Research Institution
  University of Miyazaki
Research on the pathogenesis, clinical features, diagnostic methods and treatment of acute encephalitis/encephalopathy.
- Principal Investigator
  
  MORISHIMA Tsuneo
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Pediatrics
- Research Institution
  Okayama University
急性疾患において医療行為のレベルを決定する初期検査としての血清中チトクロームC値
- Principal Investigator
  
  遠藤文夫
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
Analysis of the mutant β-actin functions in the mutant actin transduced mousePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  宮崎医科大学
A project of clinical application in a gene therapy for chronic granulomatous disease with gp91-phox deficiencyPrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Miyazaki Medical College
  Kumamoto University
Basic Study for Gene Therapy for the Patients with Chronic Granulomatous Disease -Construction of MND-gp91/PAM51-Principal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
悪性Tリンパ腫に発現したスーパーオキシド産生系の解析
- Principal Investigator
  
  金ヶさき士朗
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Newly developed retrovirus for CGD gene-therapy : Cooperarive study of its effectiveness
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1997
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Preclinical studies of gene therapy for Chronic Granulomatous DiseasePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Pediatrics
- Research Institution
  Kumamoto University
A novel gene therapeutic strategy for chronic granulomatous disease.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
悪性リンパ腫におけるスーパーオキシド産生系の発現の解析
- Principal Investigator
  
  金ケ崎士朗
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator
- Principal Investigator
  
  布井博幸
- Project Period (FY)
  1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
Analysis of molecular mechanism of inherited phagocyte disorders.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1996 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
慢性肉芽腫症の遺伝子治療の基礎的研究Principal Investigator
- Principal Investigator
  
  布井博幸
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  The University of Tokyo
悪性リンパ腫におけるスーパーオキシド産生系の解析とその発現の意義
- Principal Investigator
  
  金ヶ崎士朗
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
白血球スーパーオキシド産生系における蛋白質リン酸化の意義
- Principal Investigator
  
  大海忍
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Structural biochemistry
- Research Institution
  The University of Tokyo
慢性内芽腫症の基礎的研究 b型シトクロムおよび細胞質因子欠損の遺伝生化学的解析
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  The University of Tokyo
Activation mechanism of superoxide generating system in neutrophils upon bacterial infection.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Restoration of superoxide generating ability to the cells derived from chronic granulomatous disease by protein or gene transfer.
- Principal Investigator
  
  KANEGASAKI Shiro
- Project Period (FY)
  1993 – 1995
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  The University of Tokyo
Genetic analysis of Chronic Granulomatous Disease with cytosolic defect in JapanPrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  内科学一般
- Research Institution
  THE UNIVERSITY OF TOKYO
Analysis of the third cytosol factor involving in the neutrophil NADPH oxidasePrincipal Investigator
- Principal Investigator
  
  NUNOI Hiroyuki
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医学一般
- Research Institution
  Kumamoto University

All 2018 2016 2015 2005

All Journal Article Presentation

[Journal Article] A Hot-spot Mutation in CDC42 (p.Tyr64Cys) and Novel Phenotypes in a Third Patient with Takenouchi-Kosaki Syndrome.2018
- Author(s)
  Motokawa M, Watanabe S, Nakatomi A, Kondoh T, Matsumoto T, Morifuji K, Sawada H, Nishimura T, Nunoi H, Yoshiura KI, Moriuchi H, Dateki S.
- Journal Title
  
  J Hum Genet.
  
  Volume: 63 Issue: 3 Pages: 387-390
- DOI
  10.1038/s10038-017-0396-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16KT0112, KAKENHI-PROJECT-17K12295, KAKENHI-PROJECT-16H05159, KAKENHI-PROJECT-16K09972
[Journal Article] Necrotizing Ulcer After BCG Vaccination in a Girl With Leukocyte-adhesion Deficiency Type 1.2018
- Author(s)
  Kurosawa H, Mizukami T, Nunoi H, Kato M, Sato Y, Okuya M, Fukushima K, Katsuyama Y, Arisaka O.
- Journal Title
  
  J Pediatr Hematol Oncol.
  
  Volume: 49(1) Issue: 1 Pages: 62-66
- DOI
  10.1097/mph.0000000000000853
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K09972
[Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為比較試験―2015
- Author(s)
  立元真，古川望子，鮫島浩，布井博幸，池ノ上克
- Journal Title
  
  行動療法研究
  
  Volume: 41 Pages: 127-135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24330201
[Journal Article] 周産母子センター・小児科より紹介された子どもへの個別ペアレント・トレーニング ―予備的な無作為化比較試験―2015
- Author(s)
  立元真，古川望子，鮫島浩，布井博幸，池ノ上克
- Journal Title
  
  行動療法研究
  
  Volume: 41（2） Pages: 1-9
- NAID
  110009969917
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24330201
[Journal Article] Apoptosis under hypercytokinemia is a possible pathogenesis in influenza-associated encephalopathy.2005
- Author(s)
  Nunoi H, Mercado MR, et al.
- Journal Title
  
  Pediatr.Int. 47(2)
  
  Pages: 175-179
- NAID
  10016473876
- Data Source
  KAKENHI-PROJECT-17209037
[Presentation] CGD登録事業から学んだこと2016
- Author(s)
  布井博幸
- Organizer
  食細胞機能異常研究会
- Place of Presentation
  東京
- Invited
- Data Source
  KAKENHI-PROJECT-16K09972
[Presentation] Clinical and Genetic Profiles of Chronic Granulomatous Disease in Japan2016
- Author(s)
  Tomoyuki Mizukami, Mayumi Iwata-Okada, Toyoki Nishimura,Hiroyuki Nunoi et al
- Organizer
  European Society of Immuno Deficiency
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2016-09-21
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K09972

1. KANEGASAKI Shiro (10012767)

# of Collaborated Projects: 9 results

# of Collaborated Products: 0 results
2. KOBAYASHI Sonoko (00013764)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
3. IMAJOH-OHMI Shinobu (20160046)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
4. KURIBAYASHI Futoshi (60251443)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
5. TATSUMOTO Shin (50279965)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
6. SAMESHIMA Hiroshi (50274775)

# of Collaborated Projects: 3 results

# of Collaborated Products: 2 results
7. KIMURA Hioroshi (30303621)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. TOGASAKI Yasuko (40300040)

# of Collaborated Projects: 2 results

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9. MORISHIMA Tsuneo (90157892)

# of Collaborated Projects: 2 results

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10. OKABE Nobuhiko (10057028)

# of Collaborated Projects: 2 results

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11. ICHIYAMA Takashi (20263767)

# of Collaborated Projects: 2 results

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12. SATO Shoji (30107205)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. 武井優子 (00727886)

# of Collaborated Projects: 2 results

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14. Maeda Hiroshi (90004613)

# of Collaborated Projects: 2 results

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15. 松本良二 (20272495)

# of Collaborated Projects: 2 results

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16. 児玉由紀 (30305081)

# of Collaborated Projects: 2 results

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17. NAKAGOMI Osamu (70143047)

# of Collaborated Projects: 1 results

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18. KONDOU Kazuhiro (70234929)

# of Collaborated Projects: 1 results

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19. HOSOYA Mitsuaki (80192318)

# of Collaborated Projects: 1 results

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20. MATSUKAWA Akihiro (90264283)

# of Collaborated Projects: 1 results

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21. YOSHIKAWA Tetsushi (80288472)

# of Collaborated Projects: 1 results

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22. OKUMURA Akihisa (60303624)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. IKENOUE Tuyomu (60232211)

# of Collaborated Projects: 1 results

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24. SATO Youko (50196284)

# of Collaborated Projects: 1 results

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25. ISHIKAWA Shinichi (90404392)

# of Collaborated Projects: 1 results

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26. OGATA Akiko (70452919)

# of Collaborated Projects: 1 results

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27. ONO Yasuo (10177272)

# of Collaborated Projects: 1 results

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28. KOMIYAMA Jun (50020798)

# of Collaborated Projects: 1 results

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29. KITAGAWA Seiichi (50133278)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SENDO Fujiro (80091833)

# of Collaborated Projects: 1 results

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31. KOBAYASHI Kunihiko (60091451)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. MIZUGUCHI Masashi (20209753)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. 遠藤文夫 (00176801)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. 足立尚登 (00264292)

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35. 児玉由紀 (30305031)

# of Collaborated Projects: 1 results

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36. 今野多助 (00004846)

# of Collaborated Projects: 1 results

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37. 竹重公一朗 (10037450)

# of Collaborated Projects: 1 results

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38. 小林陽之助 (50034062)

# of Collaborated Projects: 1 results

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39. 松倉誠 (70238997)

# of Collaborated Projects: 1 results

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40. 前田泰弘 (10337206)

# of Collaborated Projects: 1 results

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41. 石田康 (20212897)

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42. 湯田拓史 (20448161)

# of Collaborated Projects: 1 results

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43. 尾之上高哉 (30631775)

# of Collaborated Projects: 1 results

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44. 金子政時 (40264387)

# of Collaborated Projects: 1 results

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45. 境泉洋 (90399220)

# of Collaborated Projects: 1 results

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46. 大平洋明 (10806269)

# of Collaborated Projects: 1 results

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47. MALY Friedrich

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
48. DINAUER Mary C.

# of Collaborated Projects: 1 results

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49. MALECH Harry

# of Collaborated Projects: 1 results

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50. FRIERICH Ern

# of Collaborated Projects: 1 results

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51. DINAUER Marr

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
52. 島津光伸

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
53. 吉浦孝一郎

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Nunoi Hiroyuki 布井 博幸

NUNOI Hiroyuki 布井 博幸

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Treatment with Polyethylene Glycol-Conjugated Fungal d-Amino Acid Oxidase Reduces Lung Inflammation in a Mouse Model of Chronic Granulomatous DiseasePrincipal Investigator

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Analysis of the mutant β-actin functions in the mutant actin transduced mousePrincipal Investigator

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A project of clinical application in a gene therapy for chronic granulomatous disease with gp91-phox deficiencyPrincipal Investigator

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Basic Study for Gene Therapy for the Patients with Chronic Granulomatous Disease -Construction of MND-gp91/PAM51-Principal Investigator

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Preclinical studies of gene therapy for Chronic Granulomatous DiseasePrincipal Investigator

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Nunoi Hiroyuki 布井博幸

NUNOI Hiroyuki 布井博幸