KOYAMA Tsukasa 小山司

Researcher Number	10113557
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2002 – 2005: 北海道大学, 大学院・医学研究科, 教授 2002: 北海道大学, 大学院・医学系研究科, 教授 2000: Hokkaido Univ.Grad.School of Medicine, Prof., 大学院・医学研究科, 教授 1993 – 1999: Hokkaido Univ.Sch.of Med., Professor, 医学部, 教授 1987 – 1992: Hokkaido University School of Medicine (Yoshihara,Te), 医学部, 助教授 1986: 北海道大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Psychiatric science / Psychiatric science Except Principal Investigator Psychiatric science
Keywords	Principal Investigator Dopamine / Schizophrenia / Methamphetamine / Serotonin / ラット / 不安 / 扁桃体 / 病態モデル / Atypical antipsychotic drug / Clozapine … More / Serotonin-Dopamine antagonist / Negative Symptoms / Prefrontal Cortex / Extrapyramidal side effects / 非定型抗精神病薬 / セロトニン / SSRI / mRNA / リチウム / 覚せい剤精神病 / NMDA / TNF-α / 胎児 / 行動観察 / 情動 / 強制水泳 / 学習 / 空間認知 / 恐怖条件付けストレス / セロトニン(5-HT) / セロトニン再取り込み阻害薬(SSRI) / c-Fos / セロトニン(S-HT) / 悪性症候群 / Fawn-Hooded系ラット / ダントロレン / FawnーHooded系ラット / Neuroleptic malignant syndrome / Animal model / Fawn-Hooded rat / Dantrolene / 前頭葉皮質ドーパミン / clozapine / ドーパミンD_4受容体 / 恐怖条件付け / Noradrenaline / Transporter / Atypical Antipsychotics / Conditioned Fear / Nitric Oxide (NO) / 一酸化窒素生成 / グルタミン / NO合成酸素阻害剤 / 覚醒剤精神病 / Nitric oxide (NO) / モノアミン酸化酵素阻害剤 / ドーパミン / SSR1 / 精神分裂症 / うつ病 / 情動ストレス / コレシストキニン / 精神分裂病 / Anxiety / Monoamine oxidase inhibitor / amygdala / Lithium / 分裂病 / 認知障害 / 前頭前野 / 統合失調症 / 治療抵抗性 / フェンサイクリジン / 認知機能障害 / 前頭葉 / schizophrenia / cognitive dysfunction / atypical antipsychotics / prefrontal cortex / トリプトファン / 5-HT受容体 … More Except Principal Investigator セロトニン / 感情障害 / Serotonin2 receptor / Atypical antipsychotic drugs / EEDQ / In vivo receptor occupancy / ドーパミン / ド-パミン / mRNA / cDNA / 抗うつ薬 / ストレス / Serotonin / CRF / 感情制御 / 脳機能画像解析 / 分子生物学 / 動物モデル / 養育環境 / ストレス脆弱性 / 発達心理学 / Dopamine Dー1 receptor / Dopamine Dー2 receptor / 非定型抗精神病薬 / 錐体外路症状 / ジ-パミン受容体 / セロトニン_2受容体 / In vivo受容体占有率 / Dopamine D-1 receptor / Dopamine D-2 receptor / 興奮性アミノ酸 / 精神分裂病 / てんかん / フェンシクリジン / NMDAレセプター / 神経毒 / 脳 / メタンフェタミン / D-セリン / GABA / グリシン結合部位 / NMDAレセプタ-複合体 / ジュロウグモ毒素 / メタボトロピックレセプタ- / Exatatory amino acid / schizophrenia / epilepsy / phencyclidine / NMDA receptor / dopamine / newrotoxin / brain / 躁うつ病 / G蛋白質 / 単核白血球 / ラット脳 / G蛋白質サブクラス / 血小板 / カルシウム / トロンビン / Depression / G protein / mononuclear leukocyte / affective disorder / 免疫 / 内分泌 / セロトユン / affective disorders / immunology / endocrinology / antidepressant / stress / serptonin / アルコール症 / 毛根 / ALDH-I / ALDH-1 / Alcoholism / Aldehyde dehydrogenase / シグナル伝達 / 神経伝達 / カテコ-ルアミン / セカンド・メッセンジャ- / ジグナル伝達 / GTP結合 / イノシト-ルリン脂質代謝 / セロトニン受容体 / β受容体 / GABA受容体 / イミプラミン結合 / 細胞内情報伝達 / 神経伝達機構 / 細胞内情報伝達系 / アドレナリン受容体 / アミノ酸受容体 / Affective Disorders / Antidepressants / Signal Transduction / Neural Transmission / Catecholamine / Second Messenger / メトアンフェタミン / 脳内透析 / 恐怖条件付け / 学習正絶望 / 学習性絶望 / Methamphetamine / Dopamine / In vivo microdialysis / Stress / Conditioned fear / Learned helplessness Less

不安の治療における前頭葉一扁桃体神経回路の役割の研究Principal Investigator
- Principal Investigator
  
  小山司
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
感情制御とその障害に関する脳科学研究
- Principal Investigator
  
  YAMAWAKI Shigeto
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hiroshima University
The mechanism for the effects of atypical antipsychotics on the cognitive dysfunction of schizophreniavia the modulation of the function of the neuronal networkPrincipal Investigator
- Principal Investigator
  
  KOYAMA Tsukasa
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  HOKKAIDO UNIVERSITY
マウス胎児脳の発達に対するTNF-αの影響-精神分裂病の病因論としての神経発達障害仮説の検証-Principal Investigator
- Principal Investigator
  
  小山司
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Study on the role of emotional stress for the pathogenesis of psychiatric disorders. -To clarify the relationship between emotional stress and central monoaminergic/peptidergic neural systems using animal models-Principal Investigator
- Principal Investigator
  
  KOYAMA Tsukasa
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Psychiatric science
- Research Institution
  HOKKAIDO UNIVERSITY
Role of nitric oxide and glutamate in methamphetamine-induced psychosisPrincipal Investigator
- Principal Investigator
  
  KOYAMA Tsukasa
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Neuro-immuno-endocrinological aspects of pathophysiology of affective disorders
- Principal Investigator
  
  YAMAWAKI Shigeto
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  HIROSHIMA UNIVERSITY
Neurochemical and pharmacological studies on the noves mode of action mechanisms of antipsychotic drugs : Preferential dopaminergic activation in the prefrontal cortex.Principal Investigator
- Principal Investigator
  
  KOYAMA Tsukasa
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Molecular biological studies on G protein mRNA of depressed patients
- Principal Investigator
  
  YAMASHITA Itaru
- Project Period (FY)
  1992 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokusei Gakuen University
  Hokkaido University
覚せい剤精神病の発症機転と再発準備性に関する実験的研究ードーパミン-グルタミン酸およびドーパミン-セロトニン相互作用の役割ーPrincipal Investigator
- Principal Investigator
  
  小山司
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Study on pathoetilogy of schizophrenia and epilepsy fowsing on EAA newrons
- Principal Investigator
  
  TORU Michio
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Tokyo Medical and Dental University, School of Medicine
Dopamine D-1, D-2 and Serotonin 2 receptor Occupation by Atypical Antipsychotic Drugs In Vivo.
- Principal Investigator
  
  MATSUBARA Shigehiro
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Animal Model of Neuroleptic Malignant SyndromePrincipal Investigator
- Principal Investigator
  
  KOYAMA Tsukasa
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Biochemical and Pharmacological Research on Affective Disorders from the Aspect of the Mechanism of Neural Transmission and Intracellural Signal Transduction
- Principal Investigator
  
  HIGUCHI Teruhiko
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  Psychiatric science
- Research Institution
  Gunma University Scholl of Medicine
  Saitama Medical University
Effect of emotional stress on onset and relapse in metal diseases -A neuroendocrinological and neurochemical study using animal models-
- Principal Investigator
  
  YAMASHITA Itaru
- Project Period (FY)
  1988 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
セロトニン関連伝達機構および生体機能に及ぼすリチウムの影響-躁うつ病に対するリチウム・トリプトファン併用療法の臨床応用に関する基礎的検討-Principal Investigator
- Principal Investigator
  
  小山司
- Project Period (FY)
  1987 – 1988
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University
Enzymological study on alcoholism
- Principal Investigator
  
  YAMASHITA Itaru
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokkaido University

All 2005 2004 2003 2002 Other

All Journal Article Book

[Book] 覚せい剤精神病と麻薬依存〜逆耐性現象とアミノ酸伝達2004
- Author(s)
  小山司, 安部川智浩, 本田稔他
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 社会不安障害の病態と治療2005
- Author(s)
  小山司
- Journal Title
  
  分子精神医学 5巻1号
  
  Pages: 87-93
- Data Source
  KAKENHI-PROJECT-16659299
[Journal Article] 社会不安・障害の病態と治療2005
- Author(s)
  小山司
- Journal Title
  
  分子精神医学 5巻1号
  
  Pages: 87-93
- Data Source
  KAKENHI-PROJECT-16659299
[Journal Article] Effect of the protein kinase C inhibitor, staurosporine, on the high dose of methamphetamine-induced behavioral sensitization to MK-8012005
- Author(s)
  Fang YR, Abekawa T, Li XB, Wang ZC, Inoue T, Koyama T
- Journal Title
  
  Psychopharmacology (On-line)(In press)
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 抗精神病薬による統合失調症の認知障害への対策2005
- Author(s)
  久住一郎, 小山司
- Journal Title
  
  精神科治療学 20
  
  Pages: 51-58
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Selective serotonin re uptake inhibitor reduces conditioned fear through its effect in the amygdala2004
- Author(s)
  Inoue T, Li XB, Abekawa T, Kitaichi Y, Izumi T, Nakagawa S, Koyama T
- Journal Title
  
  Eur J Pharmacol 497
  
  Pages: 311-316
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 統合失調症の病態モデルと治療メカニズム〜治療抵抗性と治療メカニズム2004
- Author(s)
  安部川智浩, 伊藤侯輝, 小山司
- Journal Title
  
  Schizophrenia Frontier 5
  
  Pages: 37-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of MS-153 on the acquisition and expression of conditioned fear in rats2004
- Author(s)
  Li XB, Inoue T, Abekawa T, Fang YR, Koyama T
- Journal Title
  
  Eur J Pharmacology 505
  
  Pages: 145-149
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Selective serotonin reuptake inhibitor reduces conditioned fear through its effect in the amygdala2004
- Author(s)
  Inoue T, Li XB, Abekawa T, Kitaichi Y, Izumi T, Nakagawa S, Koyama T
- Journal Title
  
  Eur J Pharmacology 497
  
  Pages: 311-316
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of MS-153 on the acuisition and expression of conditioned fear in rats2004
- Author(s)
  Li XB, Inoue T, Abekawa T, Fang YR, Koyama T
- Journal Title
  
  Eur J Pharmacol 505
  
  Pages: 145-149
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 治療抵抗性分裂病(統合失調症)への対策〜薬物療法-Clozapine2004
- Author(s)
  久住一郎, 小山司
- Journal Title
  
  Schizophrenia Frontier 4
  
  Pages: 13-17
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 治療抵抗性分裂病への対処薬物療法-Clozapine2004
- Author(s)
  久住一郎, 小山司
- Journal Title
  
  Schizophrenia Frontier 4
  
  Pages: 3713-18
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 前部帯状皮質下位領域と精神疾疾患2004
- Author(s)
  豊巻敦人, 久住一郎, 小山司
- Journal Title
  
  精神科 4
  
  Pages: 262-265
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 「統合失調症の警告期状態」に対する非定型抗精神病薬の使用経験2004
- Author(s)
  安部川智浩, 北市雄士, 松山哲晃, 小山司
- Journal Title
  
  精神神経学雑誌 106
  
  Pages: 1357-1372
- NAID
  10018962562
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 前部帯状皮質下位領域と精神疾患2004
- Author(s)
  豊巻敦人, 久住一郎, 小山司
- Journal Title
  
  精神科
  
  Pages: 262-265
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 抗精神病薬の開発動向と問題点2004
- Author(s)
  久住一郎, 小山司
- Journal Title
  
  臨床精神医学 33
  
  Pages: 263-267
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] 統合失調症の病態モデルと治療メカニズム-治療抵抗性モデルと治療メカニズム2004
- Author(s)
  安部川智浩, 伊藤侯輝, 小山司
- Journal Title
  
  Schizophrenia Frontier 5
  
  Pages: 37-43
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of NRA0045, a novel potent antagonist at dopamine D4, 5-HT2A, and 1 adrenaline receptors, and NRA0160, a selective D4 receptor antagonist, on phencyclidine-induced behavior and glutamate release in rats2003
- Author(s)
  Abekawa T, Honda M, Koyama T
- Journal Title
  
  Psychopharmacol 169
  
  Pages: 247-256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of MS-153 on the development of behavioral sensitization to stereotypy-inducing effect of phencyclidine2002
- Author(s)
  Abekawa T, Honda M, Ito K, Takeshi I, Koyama T
- Journal Title
  
  BrainR esearch 926
  
  Pages: 176-180
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of MS-153 on the development of behavioral sensitization to locomotion-and ataxia-inducing effects of phencyclidine2002
- Author(s)
  Abekawa T, Honda M, Ito K, Inoue T, Koyama T
- Journal Title
  
  Psychopharmacol 160
  
  Pages: 122-131
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287
[Journal Article] Effect of the protein kinase C inhibitor, staurosporine, on the high dose of methamphetamine-induced behavioral sensitization to dizocilpine(MK-801)
- Author(s)
  Fang YR, Abekawa T, Li XB, Wang ZC, Inoue T, Koyama T
- Journal Title
  
  Psychopharmacology (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370287

1. MATSUBARA Shigehiro (40142731)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. YAMASHITA Itaru (60000923)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MIKUNI Masahiko (00125353)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
4. KUSUMI Ichiro (30250426)

# of Collaborated Projects: 3 results

# of Collaborated Products: 6 results
5. OHMORI Tetsuro (00221135)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. YAMAWAKI Shigeto (40230601)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. ODAGAKI Yuji (10221160)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. SAITO Toshikazu (50128518)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. INOUE Takeshi (70250438)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. HIGUCHI Teruhiko (90105883)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. KATO Nobumasa (10106213)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. 市川淳二 (60184610)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. TORU Michio (20013972)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. ALIYAMA Kazufumi (40150990)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. YONEDA Yukio (50094454)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. NISHIKAWA Toru (00198441)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. KAWAI Nobufumi (00073065)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. KANBA Shigenobu (50195187)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. ABEKAWA Tomihiro (80301901)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
20. SHIBUYA Haruo (10158959)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. NOMURA Soichiro (80113091)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. ASAKURA Mikio (70103504)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 内富庸介 (60243565)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 加藤忠史 (30214381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. 中川伸 (60360905)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. 山下謙二

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

KOYAMA Tsukasa 小山 司

Research Projects

Research Products

Co-Researchers

不安の治療における前頭葉一扁桃体神経回路の役割の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The mechanism for the effects of atypical antipsychotics on the cognitive dysfunction of schizophreniavia the modulation of the function of the neuronal networkPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

マウス胎児脳の発達に対するTNF-αの影響-精神分裂病の病因論としての神経発達障害仮説の検証-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the role of emotional stress for the pathogenesis of psychiatric disorders. -To clarify the relationship between emotional stress and central monoaminergic/peptidergic neural systems using animal models-Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Role of nitric oxide and glutamate in methamphetamine-induced psychosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Neurochemical and pharmacological studies on the noves mode of action mechanisms of antipsychotic drugs : Preferential dopaminergic activation in the prefrontal cortex.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

覚せい剤精神病の発症機転と再発準備性に関する実験的研究 ードーパミン-グルタミン酸およびドーパミン-セロトニン相互作用の役割ーPrincipal Investigator

Principal Investigator

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Principal Investigator

Project Period (FY)

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Research Institution

Principal Investigator

Project Period (FY)

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Research Institution

Animal Model of Neuroleptic Malignant SyndromePrincipal Investigator

Principal Investigator

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Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

KOYAMA Tsukasa 小山司

覚せい剤精神病の発症機転と再発準備性に関する実験的研究ードーパミン-グルタミン酸およびドーパミン-セロトニン相互作用の役割ーPrincipal Investigator