Tohyama Chiharu 遠山千春

… Alternative Names

TOHYAMA Chiharu 遠山千春

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Researcher Number	10150872
Other IDs
Affiliation (based on the past Project Information) *help	2018 – 2020: 筑波大学, 医学医療系, 客員教授 2014 – 2016: 筑波大学, 医学医療系, 客員教授 2012 – 2013: 東京大学, 医学(系)研究科(研究院), 教授 2009 – 2012: The University of Tokyo, 大学院・医学系研究科, 教授 2006: The University of Tokyo, Graduate School of Medicine, Professor, 大学院医学系研究科, 教授 … More 2005: 東京大学, 大学院・医学系研究科, 教授 2001 – 2004: 独立行政法人国立環境研究所, 環境健康研究領域, 領域長 2002: 国立環境研究所, 環境健康研究領域, 領域長 2000 – 2001: 国立環境研究所, 環境健康部, 部長 1999: 国立環境研究所, 環境健康部, 部長・研究職 1994: NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES,ENVIRONMENTAL HEALTH SCIENCES DIVISION,DIRECTOR, 環境健康部, 部長 1993: 国立環境研究所, 環境健康部・病態機構研究室, 室長 Less
Review Section/Research Field	Principal Investigator Risk sciences of radiation/Chemicals / Basic Section 58020:Hygiene and public health-related: including laboratory approach / Hygiene / 環境影響評価(含放射線生物学) / Hygiene Except Principal Investigator Obstetrics and gynecology / Hygiene
Keywords	Principal Investigator 高次脳機能 / 環境化学物質 / 発達神経毒性 / PCB / メタロチオネイン / ダイオキシン / 環境 / リスク評価 / 脳発達 / 行動試験 … More / 行動柔軟性 / 環境リスク評価 / 全自動行動試験 / 幼若期マウス行動試験 / 安全性評価 / 幼若期マウス / 認知行動試験 / Gene expression / Learning performance / Dioxin / Environment / 毒性 / 複合曝露 / 遺伝子プロファイル / TCDD / ポリ塩素化ビフェニル / 社会医学 / 健康影響 / 遺伝子発現 / 学習機能 / Genotoxicity / X-irradiation / N-ethyl-N-nitrosourea / Benzo[a]pyren / 7, 12-dimethylbenz[a] anthracene / Anticarcinogenic effect / Environmental carcinogenesis / Metallothionein / 胃腫瘍 / 皮膚腫瘍 / ras遺伝子 / 肺腫瘍 / 小核試験 / ベンゾ(a)ピレン / ジメチルベンズ(a)アントラセン / 遺伝子欠損マウス / 化学発がん / 遺伝子損傷 / 放射線 / エチルニトロソウレア / ベンゾ[a]ピレン / ジメチルベンズ[a]アントラセン / 抗発がん作用 / 環境発がん / IN SITU HYBRIDIZATION / METALLOTHIONEIN / MERCURY / CADMIUM / HEAVY METALS / RENAL DAMAGE / X-RAY FLUORESCENCE MICROANALYSIS / 二次元イメージング / シンクロトロン放射光 / 腎毒性 / in situ hybridization / 水銀 / カドミウム / 重金属 / 腎障害 / 放射光蛍光X線分析 / ストレス障害モデル / 社会行動 / 母子行動 / 周産期 / ストレス応答 / 神経内分泌 / 毒性発現 / 健康リスク / トキシコロジー / 化学物質曝露 / 細胞移動 / 軸索 / 樹状突起 / 胎児期起源環境疾患 / 認知・行動毒性 / 超音波発声 / 芳香族炭化水素受容体 / 内分泌かく乱作用 / アリール炭化水素受容体 / ヒ素 / ビスフェノールA / 微細形態 / 衛生 / 栄養学 / 遺伝子 / ゲノム / ト芳香族炭化水素 / マウス / 行動毒性 / 芳香族炭化水素 … More Except Principal Investigator endocrinc disruptor / estrogen receptor / blastocyst / bisphenol A / preimpaniation exposure / in vitro fertilization / low dose effect / emhryo / Ahレセプター / 内分泌撹乱物質 / 卵胞液 / 不妊症 / 子宮内膜症 / 内分泌撹乱化学物質 / 性差 / 多嚢胞性卵巣症候群 / ビスフェノールA / 低用量作用 / 次世代影響 / ダイオキシンレセプター / ダイオキシン / ピスフェノールA / エストロゲンレセプター / 初期胚 / 内分泌攪乱化学物質 / 感受性 / メタロチオネイン / 交絡因子 / 低濃度曝露 / セレン / カドミウム / 水銀 / 鉛 Less

Establishment of test method to detect developmental disorders in juvenile animal models by environmental factorsPrincipal Investigator
- Principal Investigator
  
  Tohyama Chiharu
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 58020:Hygiene and public health-related: including laboratory approach
- Research Institution
  University of Tsukuba
Elucidation of mechanisms of developmental neurotoxicity by micro-morphological analysisPrincipal Investigator
- Principal Investigator
  
  Tohyama Chiharu
- Project Period (FY)
  2012 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (S)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  University of Tsukuba
  The University of Tokyo
in vivo解析によるダイオキシン発達神経毒性メカニズムの解明Principal Investigator
- Principal Investigator
  
  遠山千春
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  The University of Tokyo
Developmental toxicity of the neuroendocrine stress response system caused by environmental chemicalsPrincipal Investigator
- Principal Investigator
  
  TOHYAMA Chiharu
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  The University of Tokyo
Elucidation of developmental neurotoxicity mechanisms of polycyclic aromatic hydrocarbons via aryl hydrocarbon receptorPrincipal Investigator
- Principal Investigator
  
  TOHYAMA Chiharu
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  The University of Tokyo
亜鉛欠乏による毒性感受性遺伝子への胎生期エピジェネティックプログラミングの解析Principal Investigator
- Principal Investigator
  
  遠山千春
- Project Period (FY)
  2009 – 2010
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  The University of Tokyo
The profiling of gene expression evoked by co-exposure to dioxin and polychlorinated biphenyl.Principal Investigator
- Principal Investigator
  
  TOHYAMA Chiharu
- Project Period (FY)
  2003 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Risk sciences of radiation/Chemicals
- Research Institution
  The University of Tokyo
  National Institute for Environmental Studies
重金属中毒学のパラダイムシフト
- Principal Investigator
  
  佐藤洋
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Hygiene
- Research Institution
  Tohoku University
Physiological significance of metallothionein on environmental carcinogenesisPrincipal Investigator
- Principal Investigator
  
  TOHYAMA Chiharu
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Hygiene
- Research Institution
  National Institute for Environmental Studies
ANALYSIS OF ENDOCRINE DISRUPTORS AFFECTING REPRODUCTIVE FUNCTION
- Principal Investigator
  
  TSUTUMI Osamu
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  THE UNIVERSITY OF TOKYO
NEW METHODOLOGY FOR EVALUATION OF RENAL DAMAGE CAUSED BY HEAVY METALS ON THE TUBULAR LEVELPrincipal Investigator
- Principal Investigator
  
  TOHYAMA Chiharu
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  環境影響評価(含放射線生物学)
- Research Institution
  NATIONAL INSTITUTE FOR ENVIRONMENTAL STUDIES

[Journal Article] Embryonic and postnatal expression of aryl hydrocarbon receptor mRNA in mouse brain2017
- Author(s)
  Kimura E, Tohyama C
- Journal Title
  
  Frontiers in Neuroanatomy
  
  Volume: 11 Pages: 1-10
- DOI
  10.3389/fnana.2017.00004
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24221003
[Journal Article] Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse2017
- Author(s)
  Eiki Kimura, Ken-ichiro Kubo, Toshihiro Endo, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 42 Issue: 1 Pages: 25-30
- DOI
  10.2131/jts.42.25
- NAID
  130005286645
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01293, KAKENHI-PLANNED-16H06482, KAKENHI-PROJECT-24221003, KAKENHI-PROJECT-15H02355, KAKENHI-PROJECT-26241016, KAKENHI-PROJECT-14J06373, KAKENHI-PROJECT-15K09723, KAKENHI-PROJECT-26430075
[Journal Article] In utero and lactational dioxin exposure induces Sema3b and Sema3g gene expression in the developing mouse brain2016
- Author(s)
  Kimura E, Endo T, Yoshioka W, Ding Y, Ujita W, Kakeyama M, Tohyama C
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 476 Issue: 2 Pages: 108-113
- DOI
  10.1016/j.bbrc.2016.05.048
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003, KAKENHI-PROJECT-26241016, KAKENHI-PROJECT-14J06373
[Journal Article] Prenatal Exposure to Arsenic Impairs Behavioral Flexibility and Cortical Structure in Mice2016
- Author(s)
  Aung KH, Kyi-Tha-Thu C, Sano K, Nakamura K, Tanoue A, Nohara K, Kakeyama M, Tohyama C, Tsukahara S, Maekawa F
- Journal Title
  
  Frontiers in Neuroscience
  
  Volume: 10 Pages: 1-12
- DOI
  10.3389/fnins.2016.00137
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24221003, KAKENHI-PROJECT-15K14556
[Journal Article] AhR signaling activation disrupts migration and dendritic growth of olfactory interneurons in the developing mouse2016
- Author(s)
  Kimura E, Ding Y, Tohyama C
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 1-11
- DOI
  10.1038/srep26386
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24221003
[Journal Article] In utero bisphenol A exposure induces abnormal neuronal migration in the cerebral cortex of mice.2016
- Author(s)
  Wenting Ling, Toshihiro Endo, Ken-ichiro Kubo, Masaki Kakeyama, Kazunori Nakajima, and Chiharu Tohyama.
- Journal Title
  
  Front. Endocrinol.
  
  Volume: 7 Pages: 7-7
- DOI
  10.3389/fendo.2016.00007
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01293, KAKENHI-PROJECT-24221003, KAKENHI-PROJECT-15H02355
[Journal Article] Developmental neurotoxicity test guidelines: problems and perspectives2016
- Author(s)
  Tohyama C
- Journal Title
  
  The Journal of Toxicological Sciences
  
  Volume: 41 Issue: Special Pages: SP69-SP79
- DOI
  10.2131/jts.41.SP69
- NAID
  130005399499
- ISSN
  0388-1350, 1880-3989
- Language
  English
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24221003
[Journal Article] Developmental origin of abnormal dendritic growth in the mouse brain induced by in utero disruption of aryl hydrocarbon receptor signaling.2015
- Author(s)
  Eiki Kimura, Ken-ichiro Kubo, Chieri Matsuyoshi, Seico Benner, Mayuko Hosokawa, Toshihiro Endo, Wenting Ling, Masanobu Kohda, Kazuhito Yokoyama, Kazunori Nakajima, Masaki Kakeyama, and Chiharu Tohyama.
- Journal Title
  
  Neurotoxicol. Teratol.
  
  Volume: 52 Pages: 42-50
- DOI
  10.1016/j.ntt.2015.10.005
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PUBLICLY-15H01293, KAKENHI-PROJECT-26241016, KAKENHI-PROJECT-24221003, KAKENHI-PROJECT-15H02355
[Journal Article] Prenatal exposure to bisphenol A impacts neuronal morphology in the hippocampal CA1 region in developing and aged mice.2015
- Author(s)
  Kimura E, Matsuyoshi C, Miyazaki W, Benner S, Hosokawa M, Yokoyama K, Kakeyama M, Tohyama C.
- Journal Title
  
  Archives of Toxicology
  
  Volume: in press Issue: 3 Pages: 691-700
- DOI
  10.1007/s00204-015-1485-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26870445, KAKENHI-PROJECT-24221003
[Journal Article] Disruption of paired-associate learning in rat offspring perinatally exposed to dioxins2013
- Author(s)
  Kakeyama M, Endo T, Zang Y, Miyazaki Y, Tohyama C
- Journal Title
  
  Archives of Toxicology
  
  Volume: 88 Pages: 789-98
- DOI
  10.1007/s00204-013-1161-y
- NAID
  120006986679
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21671002, KAKENHI-PROJECT-22681008, KAKENHI-PROJECT-24221003
[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in IntelliCage.2011
- Author(s)
  Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
- Journal Title
  
  Behav Brain Res.
  
  Volume: 221 Pages: 172-181
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186
[Journal Article] Polychlorinated dioxins, furans and biphenyls in the blood of children and adults living in a dioxin-contaminated area in Tokyo2011
- Author(s)
  Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M, Ohkubo S.
- Journal Title
  
  Environ Health Prev Med
  
  Volume: 16 Issue: 1 Pages: 6-15
- DOI
  10.1007/s12199-010-0156-z
- NAID
  10029519698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186
[Journal Article] Automated test of behavioral flexibility in mice using a behavioral sequencing task in Intelli Cage2011
- Author(s)
  Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wolfer DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
- Journal Title
  
  Behav Brain Res
  
  Volume: 221 Issue: 1 Pages: 172-181
- DOI
  10.1016/j.bbr.2011.02.037
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186, KAKENHI-PROJECT-21671002, KAKENHI-PROJECT-22681008, KAKENHI-PROJECT-22790228, KAKENHI-PROJECT-23310043
[Journal Article] Polychlorinated dioxins, furans and biphenyls in the blood of children and adults living in a dioxin-contaminated area in Tokyo.2011
- Author(s)
  Tohyama C, Uchiyama I, Hoshi S, Hijiya M, Miyata H, Nagai M, Nakai S, Yauchi M, Ohkubo S.
- Journal Title
  
  Environ Health Prev Med.
  
  Volume: 16 Pages: 6-15
- NAID
  10029519698
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186
[Journal Article] Development of novel behavioral toxicity tests in rodents aimed for application to health risks in humans2011
- Author(s)
  掛山正心
- Journal Title
  
  Japanese Journal of Animal Psychology
  
  Volume: 61 Issue: 1 Pages: 33-42
- DOI
  10.2502/janip.61.1.11
- NAID
  130000780092
- ISSN
  0916-8419, 1880-9022
- Language
  Japanese
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J05801, KAKENHI-PROJECT-21390186, KAKENHI-PROJECT-21671002
[Journal Article] In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice2010
- Author(s)
  Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C
- Journal Title
  
  Neurotoxicology (掲載確定,印刷中)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186
[Journal Article] In utero and lactational exposure to low doses of chlorinated and brominated dioxins induces deficits in the fear memory of male mice2010
- Author(s)
  Haijima A, Endo T, Zhang Y, Miyazaki W, Kakeyama M, Tohyama C.
- Journal Title
  
  Neurotoxicology
  
  Volume: 31 Issue: 4 Pages: 385-390
- DOI
  10.1016/j.neuro.2010.04.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21390186, KAKENHI-PROJECT-22681008
[Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007
- Author(s)
  Sakata Y., Yoshioka W, Tohyama C., Ohsako S.
- Journal Title
  
  Biochem Biophys Res Comm 355
  
  Pages: 687-692
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Induction of metallothionein by manganese is completely dependent on interleukin-6 production.2007
- Author(s)
  Kobayashi K, Kuroda J, Shibata N, Hasegawa T, Seko Y, Satoh M, Tohyama C, Takano H, Imura N, Sakabe K, Fujishiro H, Himeno S
- Journal Title
  
  J Pharmacol Exp Ther. 320
  
  Pages: 721-727
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007
- Author(s)
  Sakata Y., Yoshioka W., Tohyama C., Ohsako S.
- Journal Title
  
  Biochem Biophys Res Comm 355
  
  Pages: 687-692
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Internal genomic sequence of human CYP1A1 gene is involved in superinduction of dioxin-induced CYP1A1 transcription by cycloheximide.2007
- Author(s)
  Sakata Y, Yoshioka W, tohyama C, Ohsako S.
- Journal Title
  
  Biochem Biophys Res Comm 355
  
  Pages: 687-692
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006
- Author(s)
  Kawakami T., Ishimura R., Nohara K., Takeda K., Tohyama, C., Ohsako, S.
- Journal Title
  
  Tox.Appl.Pharmacol. 212
  
  Pages: 224-236
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Comparison of the 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-induced CYP1A1 gene expression profile in lymphocytes from mice, rats, and humans : Most potent induction in humans.2006
- Author(s)
  Nohara K, Ao K, Miyamoto Y, Ito T, Suzuki T, Toyoshiba H, Tohyama C.
- Journal Title
  
  Toxicology 225
  
  Pages: 204-213
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.2006
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Tohyama C.
- Journal Title
  
  Toxicology. 227
  
  Pages: 117-126
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Differential susceptibilities of Holtzman and Sprague-Dawley rats to fetal death and placental dysfunction induced by 2,3,7,8-teterachlorodibenzo-p-dioxin (TCDD) despite the identical primary structure of the aryl hydrocarbon receptor.2006
- Author(s)
  Kawakami T., Ishimura R., Nohara K., Takeda K., Tohyama C., Ohsako S.
- Journal Title
  
  Tox. Appl. Pharmacol. 212
  
  Pages: 224-236
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.2006
- Author(s)
  Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE
- Journal Title
  
  Toxicol Sci. 93
  
  Pages: 223-241
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses contextual fear conditioning-accompanied activation of cyclic AMP response element-binding protein in the hippocampal CA1 region of male rats.2006
- Author(s)
  Mitsui T, Sugiyama N, Maeda S, Tohyama C, Arita J.
- Journal Title
  
  Neurosci Lett. 398
  
  Pages: 206-210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006
- Author(s)
  Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
- Journal Title
  
  Toxicol. Sci. 225
  
  Pages: 204-213
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Induction of metallothionein by manganese is completely dependent on interleukin-6 production.2006
- Author(s)
  Kobayashi K, Kuroda J, Shibata N, Hasegawa T, Seko Y, Satoh M, Tohyama C, Takano H, Imura N, Sakabe K, Fujishiro H, Himeno S.
- Journal Title
  
  J Pharmacol Exp Ther 320(2)
  
  Pages: 721-727
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin suppresses contextual fear conditioning-accompanied activation of cyclic AMP response element-binding protein in the hippocampal CA1 region of male rats.2006
- Author(s)
  Mitsui T, Sugiyama N, Maeda S, Tohyama C, Arita J
- Journal Title
  
  Neurosci Lett. 389
  
  Pages: 206-210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin.2006
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Tohyama C.
- Journal Title
  
  Toxicology 227(1-2)
  
  Pages: 117-126
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Localization of cytochrome P450 1A1 in a specific region of hydronephrotic kidney of rat neonates lactationally exposed to 2,3,7,8-tetrachlorodibenzo-P-dioxin.2006
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Tohyama C
- Journal Title
  
  Toxicology. 227
  
  Pages: 117-126
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] The 2005 World Health Organization reevaluation of human and Mammalian toxic equivalency factors for dioxins and dioxin-like compounds.2006
- Author(s)
  Van den Berg M, Birnbaum LS, Denison M, De Vito M, Farland W, Feeley M, Fiedler H, Hakansson H, Hanberg A, Haws L, Rose M, Safe S, Schrenk D, Tohyama C, Tritscher A, Tuomisto J, Tysklind M, Walker N, Peterson RE.
- Journal Title
  
  Toxicol Sci. 93
  
  Pages: 223-241
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo -p- dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006
- Author(s)
  Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
- Journal Title
  
  Toxicol.Sci. 91
  
  Pages: 265-274
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Suppressive effect of 2,3,7,8-tetrachlorodibenzo -p- dioxin on vascular remodeling that takes place in the normal labyrinth zone of rat placenta during late gestation.2006
- Author(s)
  Ishimura R., Kawakami T., Ohsako S., Nohara K., Tohyama C.
- Journal Title
  
  Toxicol. Sci. 91
  
  Pages: 265-274
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Localization and role of metallothioneins in the olfactory pathway after exposure to mercury vapor.2005
- Author(s)
  Shimada A, Nagayama Y, Morita T, Yoshida M, Suzuki JS, Satoh M, Tohyama C.
- Journal Title
  
  Exp Toxicol Pathol. 57
  
  Pages: 117-125
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] T cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)2005
- Author(s)
  Inouye K, Pan X, Imai N, Ito T, Takei T, Tohyama C, Nohara K
- Journal Title
  
  Chemosphere 60
  
  Pages: 907-913
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.2005
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Ikushiro S, Tohyama C.
- Journal Title
  
  Toxicol Sci. 85
  
  Pages: 607-614
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Disruption of Thyroid Homone Homeostasis at Weaning of Holtzman Rats by Lactational But Not in Utero Exposure to 2,3,7,8-Tetrachlorodibenzo-p-Dioxin2005
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Ikushiro Sl, Tohyama C.
- Journal Title
  
  Toxicol. Sci. (in press)
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Disruption of thyroid hormone homeostasis at weaning of Holtzman rats by lactational but not in utero exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.2005
- Author(s)
  Nishimura N, Yonemoto J, Nishimura H, Ikushiro S, Tohyama C
- Journal Title
  
  Toxicol Sci. 85
  
  Pages: 607-614
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Constitutivery active aryl-hydrocarbon receptor expressed specially in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes2005
- Author(s)
  Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C.
- Journal Title
  
  J. Immunol. 174・5
  
  Pages: 2770-2777
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes.2005
- Author(s)
  Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C
- Journal Title
  
  J Immunol. 174
  
  Pages: 2770-2777
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SKHEP-1 to dioxin.2005
- Author(s)
  Shiizaki K., Ohsako, S., Koyama, T., Nagata R., Yonemoto, J., Tohyama, C.
- Journal Title
  
  Toxicol.Lett. 160
  
  Pages: 22-33
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Localization and role of metallothioneins in the olfactory pathway after exposure to mercury vapor.2005
- Author(s)
  Shimada A, Nagayama Y, Morita T, Yoshida M, Suzuki JS, Satoh M, Tohyama C
- Journal Title
  
  Exp Toxicol Pathol. 57
  
  Pages: 117-125
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice.2005
- Author(s)
  Nishimura N, Yonemoto J, Miyabara Y, Fujii-Kuriyama Y Tohyama C.
- Journal Title
  
  Arch Toxicol 79
  
  Pages: 260-267
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] In utero and lactational exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation.2005
- Author(s)
  Ikeda M, Mitsui T, Setani K, Tamura M, Kakeyama M, Sone H, Tohyama C, Tomita T
- Journal Title
  
  Tox. Appl. Pharmacol. 205
  
  Pages: 98-105
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Constitutively active aryl hydrocarbon receptor expressed specifically in T-lineage cells causes thymus involution and suppresses the immunization-induced increase in splenocytes.2005
- Author(s)
  Nohara K, Pan X, Tsukumo S, Hida A, Ito T, Nagai H, Inouye K, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Tohyama C.
- Journal Title
  
  J Immunol. 174
  
  Pages: 2770-2777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice.2005
- Author(s)
  Nagai H, Takei T, Tohyama C, Kubo M, Abe R, Nohara K.
- Journal Title
  
  Int Immunopharmacol. 5
  
  Pages: 331-343
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] In utero and lactational exposure to 2,3,7,8tetrachlorodibenzo-p-dioxin in rats disrupts brain sexual differentiation.2005
- Author(s)
  Ikeda M, Mitsui T, Setani K, Tamura M, Kakeyama M, Sone H, Tohyama C, Tomita T.
- Journal Title
  
  Toxicol Appl Pharmacol. 205
  
  Pages: 98-105
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] cell-derived IL-5 production is a sensitive target of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).2005
- Author(s)
  Inouye K, Pan X, Imai N, Ito T, Takei T, Tohyama C, Nohara K.
- Journal Title
  
  Chemosphere 60
  
  Pages: 907-913
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Search for the target genes involved in the suppression of antibody production by TCDD in C57BL/6 mice.2005
- Author(s)
  Nagai H, Takei T, Tohyama C, Kubo M, Abe R, Nohara K
- Journal Title
  
  Int Immunopharmacol. 5
  
  Pages: 331-343
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SKHEP-1 to dioxin.2005
- Author(s)
  Shiizaki K., Ohsako S., Koyama T., Nagata R., Yonemoto J., Tohyama C.
- Journal Title
  
  Toxicol. Lett. 160
  
  Pages: 22-33
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in aryl hydrocarbon receptor-null mice.2005
- Author(s)
  Nishimura N, Yonemoto J, Miyabara Y, Fujii-Kuriyama Y, Tohyama C
- Journal Title
  
  Arch Toxicol 79
  
  Pages: 260-267
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] A constitutively active arylhydrocarbon receptor inhibits growth of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.2004
- Author(s)
  Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Mimura J., Lin T-M., Peterson R.E., Tohyama C., Nohara K.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 25204-25210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] A constitutively active arylhydrocarbon receptor inhibits growth of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.2004
- Author(s)
  Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Mimura J., Lin T-M., Peterson RE., Tohyama C., Nohara K.
- Journal Title
  
  J.Biol.Chem. 279
  
  Pages: 25204-25210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] MP7/ActRIIB regulates estrogenependent apoptosis : New biomarkers for environmental estrogens.2004
- Author(s)
  Kusumegi T., Tanaka J., Kawano M., Yonemoto J., Tohyama C., Sone H.
- Journal Title
  
  J.Biochem.Mol.Toxicol. 18
  
  Pages: 1-11
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] MP7/ActRIIB regulates estrogen-dependent apoptosis : New biomarkers for environmental estrogens.2004
- Author(s)
  Kusumegi T., Tanaka J., Kawano M., Yonemoto J., Tohyama C., Sone H
- Journal Title
  
  J. Biochem. Mol. Toxicol. 18
  
  Pages: 1-11
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Altered thyroxin and retinoid metabolic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin in anyl hydrocarbon-null mice2004
- Author(s)
  Nishimura N, Yonemoto J, Miyabara Y, Fujii-Kuriyama Y, Tohyama C.
- Journal Title
  
  Arch. Toxicol. (in press)
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-diosin (TCDD) in the mouse.2004
- Author(s)
  Fukuzawa N.H., Ohsako S., Wu Q., Sakaue M., Fujii-Kuriyama Y, Baba T., Tohyama C.
- Journal Title
  
  Mol.Cell.Endocrinol. 221(1-2)
  
  Pages: 87-96
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] A constitutively active arylhydrocarbon receptor induces growth inhibition of jurkat T cells through changes in the expression of genes related to apoptosis and cell sysle arrest2004
- Author(s)
  Ito T, Tsukumo S, Suzuki N, Motohashi H, Yamamoto M, Fujii-Kuriyama Y, Mimura J, Lin TM, Peterson RE, Tohyama C, Nohara K.
- Journal Title
  
  J. Biol. Chem. 279・24
  
  Pages: 25204-25210
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] A constitutively active arylhydrocarbon receptor inhibits growth of Jurkat T cells through changes in the expression of genes related to apoptosis and cell cycle arrest.2004
- Author(s)
  Ito T., Tsukumo S., Suzuki N., Motohashi H., Yamamoto M., Fujii-Kuriyama Y., Mimura J., Lin T-M., Peterson R.E., Tohyama C., Nohara K.
- Journal Title
  
  J. Biol. Chem. 279
  
  Pages: 25204-25210
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2.2004
- Author(s)
  Wu Q., Ohsako S., Ishimura R., Suzuki J.S., Tohyama C.
- Journal Title
  
  Biol.Reproduction 70
  
  Pages: 1790-1797
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-diosin (TCDD) in the mouse.2004
- Author(s)
  Fukuzawa N.H., Ohsako S., Wu Q., Sakaue M., Fujii-Kuriyama Y, Baba T., Tohyama C.
- Journal Title
  
  Mol. Cell. Endocrinol. 221
  
  Pages: 87-96
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Testicular cytochrome P450scc and LHR as possible targets of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the mouse2004
- Author(s)
  Fukuzawa NH, Ohsako S, Wu Q, Sakaue M, Fujii-Kuriyama Y, Baba T, Tohyama C.
- Journal Title
  
  Mol. Cell. Endocrinol. 221・1-2
  
  Pages: 87-96
- Data Source
  KAKENHI-PROJECT-15201014
[Journal Article] Exposure of Mouse Preimplantation Embryos to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Alters the Methylation Status of Imprinted Genes H19 and Igf2.2004
- Author(s)
  Wu Q., Ohsako S., Ishimura R., Suzuki J.S., Tohyama C.
- Journal Title
  
  Biol. Reproduction 70
  
  Pages: 1790-1797
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15201014
[Presentation] 幼若期マウスの全自動認知行動毒性試験法の確立2021
- Author(s)
  遠藤俊裕、前川文彦、遠山千春
- Organizer
  第48回日本毒性学会学術年会
- Data Source
  KAKENHI-PROJECT-18H03036
[Presentation] Development of an automated cognitive behavioral testing method for juvenile mice in a group-housed environment and its application to developmental neurotoxicological study2021
- Author(s)
  Toshihiro Endo, Fumihiko Maekawa, Chiharu Tohyama
- Organizer
  EUROTOX 20212021
- Data Source
  KAKENHI-PROJECT-18H03036
[Presentation] Automated Cognitive Assay for Juvenile Mice:An application to a mixed-sex colony of C57BL/6N strain in IntelliCage2019
- Author(s)
  Toshihiro ENDO, Seico BENNER, Hans-Peter LIPP, Chiharu TOHYAMA
- Organizer
  第6回アジア神経精神薬理学会
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H03036
[Presentation] 「個性」はいつ現れるか？：離乳後からの全成長過程を追うマウス高次脳機能試験系の確立2019
- Author(s)
  遠藤俊裕、ベナー聖子、遠山千春
- Organizer
  第8回日本DOHaD学会学術集会
- Data Source
  KAKENHI-PROJECT-18H03036
[Presentation] 幼若期マウスにおける集団飼育ホームケージ環境下全自動認知行動試験法の確立2019
- Author(s)
  遠藤俊裕、ベナー聖子、Hans-Peter LIPP、遠山千春
- Organizer
  第49回日本神経精神薬理学会
- Data Source
  KAKENHI-PROJECT-18H03036
[Presentation] In utero and lactational TCDD exposure impairs ultrasonic vocalization of neonatal mice2017
- Author(s)
  Eiki Kimura, Chiharu Tohyama
- Organizer
  Society of Toxicology (56th Annual Meeting and ToxExpo)
- Place of Presentation
  Baltimore Convention Center, Baltimore, Maryland, USA
- Year and Date
  2017-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 「環境ホルモン」と毒性学：問題提起から今日まで2016
- Author(s)
  遠山千春
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  愛知県名古屋市（ウインクあいち）
- Year and Date
  2016-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Significance of AHR signaling on the mammalian brain development2016
- Author(s)
  Kimura E, Tohyama C
- Organizer
  AHR Conference 2016
- Place of Presentation
  University of Rochester School of Medicine, Rochester, New York, USA
- Year and Date
  2016-08-03
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 周産期ダイオキシン曝露が発達期マウスの神経回路構築に及ぼす影響2016
- Author(s)
  木村栄輝、遠藤俊裕、吉岡亘、松吉智瑛里、宇治田和佳、掛山正心、遠山千春
- Organizer
  環境ホルモン学会第19回研究発表会
- Place of Presentation
  茨城県つくば市（文部科学省研究交流センター）
- Year and Date
  2016-12-08
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 新生仔マウスの超音波発声を指標とした新たな毒性評価手法の検討2016
- Author(s)
  木村栄輝、遠山千春
- Organizer
  第43回日本毒性学会学術年会
- Place of Presentation
  愛知県名古屋市（ウインクあいち）
- Year and Date
  2016-06-29
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Constitutive activation of AhR signaling disrupts dendritic growth and cellular migration of cortical pyramidal neurons in the developing mouse brain2016
- Author(s)
  Kimura E, Kubo K, Endo T, Ling W, Nakajima K, Kakeyama M, Tohyama C
- Organizer
  Society of Toxicology (55th Annual Meeting and ToxExpo)
- Place of Presentation
  New Orleans, Louisiana, USA
- Year and Date
  2016-03-12
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 神経細胞におけるAhRシグナルの活性化が発達期の細胞移動および形態に与える影響2015
- Author(s)
  木村栄輝、丁雲潔、掛山正心、遠山千春
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県金沢市（石川県立音楽堂、金沢市アートホール、ホテル日航金沢）
- Year and Date
  2015-06-29
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 健康環境医工学における毒性学研究の展開2015
- Author(s)
  遠山千春
- Organizer
  第42回日本毒性学会学術年会
- Place of Presentation
  石川県金沢市（石川県立音楽堂、金沢市アートホール、ホテル日航金沢）
- Year and Date
  2015-06-29
- Invited
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] AhR activation and TCDD exposure impair dendritic morphology in the developing olfactory bulb2015
- Author(s)
  Kimura E, Ding Y, Kakeyama M, Tohyama C
- Organizer
  The 51st Congress of the European Societies of Toxicology
- Place of Presentation
  Porto, Portugal
- Year and Date
  2015-09-13
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 発達期大脳皮質ニューロンにおけるAhRシグナル活性化が樹状突起成長と移動距離に及ぼす影響2015
- Author(s)
  木村栄輝、久保健一郎、遠藤俊裕、凌文てい、仲嶋一範、掛山正心、遠山千春
- Organizer
  第18回環境ホルモン学会
- Place of Presentation
  栃木県下野市（自治医科大学）
- Year and Date
  2015-12-10
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Activation of AhR signaling and perinatal TCDD exposure impair neuronal morphology in the developing olfactory bulb2015
- Author(s)
  Ding Y, Kimura E, Kakeyama M, Tohyama C
- Organizer
  The 7th International Congress of Asia Society of Toxicology
- Place of Presentation
  Jeju island, Korea
- Year and Date
  2015-06-23
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Novel methods to study how environmental factors affect the developing rodent brain2015
- Author(s)
  Tohyama C
- Organizer
  The 7th International Congress of Asia Society of Toxicology
- Place of Presentation
  Jeju island, Korea
- Year and Date
  2015-06-23
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Abnormal neuronal migration and behavior in mice exposed in utero to Bisphenol A2014
- Author(s)
  Ling W, Endo T, Miyazaki W, Kimura E, Kubo K, Nakajima K, Kakeyama M, and Tohyama C
- Organizer
  53rd Annual Meeting of the Society of Toxicology and ToxExpo
- Place of Presentation
  Phoenix, Arizona, USA
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Impact of perinatal TCDD exposure on neuroendocrine stress response system in mice2014
- Author(s)
  Benner S, Inoshita T, Ding Y, Kakeyama M, and Tohyama C.
- Organizer
  53rd Annual Meeting of the Society of Toxicology and ToxExpo
- Place of Presentation
  Phoenix, Arizona, USA
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 周産期低用量ダイオキシン曝露マウスの恐怖情動性評価2013
- Author(s)
  ベナー聖子、〓島旭、小早川令子、小早川高、掛山正心、遠山千春
- Organizer
  第12回分子予防環境医学研究会
- Place of Presentation
  茨城県つくば市、つくばインフォーメーションプラザ
- Year and Date
  2013-02-01
- Data Source
  KAKENHI-PROJECT-24651059
[Presentation] Perinatal Exposure to Bisphenol A Affects Cortical Development and Induces Impulsive Behavior in Mice2013
- Author(s)
  Ling W, Endo T, Miyazaki W, Kimura E, Kubo K, Nakajima K, Kakeyama M, Tohyama M
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 胎仔期ビスフェノールA曝露によるマウス大脳皮質形成障害と衝動行動2013
- Author(s)
  凌文てい、遠藤俊裕、宮崎航、木村栄輝、久保健一郎、仲嶋一範、掛山正心、遠山千春
- Organizer
  Neuro2013 (第36回日本神経科学大会)
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Abnormality in Fear-Related Emotional Function in Mice Perinatally Exposed to a Low Dose of TCDD2013
- Author(s)
  S. Benner, A. Haijima, Y. Zhang, R. Kobayakawa, K. Kobayakawa, M. Kakeyama C. Tohyama
- Organizer
  52nd Annual Meeting of the Society of Toxicology (SOT)
- Place of Presentation
  Convention Center, San Antonio, Texas, USA
- Year and Date
  2013-03-13
- Data Source
  KAKENHI-PROJECT-24651059
[Presentation] Behavioral flexibililty in mice: Development of a novel high-throughput assay for comprehensive analysis applicable to psychiatry research2013
- Author(s)
  Endo T, Benner S, Endo N, Furuse T, Wakana S, Kajii Y, Wolfer D P, Lipp H P, Tohyama C, Kakeyama M
- Organizer
  The 11th World Federation of Societies of Biological Psychiatry（第11回世界生物学的精神医学会国際会議）
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 周産期TCDD曝露モデルマウスにおけるストレス応答系への発達毒性影響2013
- Author(s)
  ベナー聖子, 井下太貴, 丁雲潔, 掛山正心, 遠山千春
- Organizer
  環境ホルモン学会第16回研究発表会
- Place of Presentation
  東京大学　（東京都文京区）
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] マウスにおける行動柔軟性：包括的解析のための新規ハイスループット試験系の開発2013
- Author(s)
  遠藤俊裕、ベナー聖子、遠藤のぞみ、古瀬民夫、若菜茂晴、梶井靖、David P. Wolfer、Hans-Peter Lipp、遠山千春、掛山正心
- Organizer
  Neuro2013 (第36回日本神経科学大会)
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 周産期化学物質曝露による神経発達毒性・高次脳機能異常の検出手法開発2013
- Author(s)
  遠山千春、掛山正心
- Organizer
  第40回　日本毒性学会学術年会
- Place of Presentation
  千葉県千葉市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Exposure to Bisphenol A during Gestation Alters Neuronal Morphology in the Hippocampus of Mouse Offspring2013
- Author(s)
  Kimura E, Miyazaki W, Matsuyoshi C, Kakeyama M, Tohyama C
- Organizer
  The XIII International Congress of Toxicology
- Place of Presentation
  Seoul, Korea
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] Perinatal Exposure to Bisphenol A Affects Cortical Development and Induces Impulsive Behavior in Mice2013
- Author(s)
  Ling W, Endo T, Miyazaki W, Kimura E, Kubo K, Nakajima K, Kakeyama M, Tohyama C
- Organizer
  World Federation of Societies of Biological Psychiatry Congress 2013
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] 発達期における低用量TCDD曝露がマウスの恐怖情動性に及ぼす影響2013
- Author(s)
  ベナー聖子、〓島旭、小早川令子、小早川高、掛山正心、遠山千春
- Organizer
  第83回日本衛生学会学術総
- Place of Presentation
  金沢市、金沢美術工芸大学
- Year and Date
  2013-03-24
- Data Source
  KAKENHI-PROJECT-24651059
[Presentation] In utero exposure to Bisphenol A interrupts cerebral cortex development and behavior in mice2013
- Author(s)
  Ling W, Endo T, Miyazaki W, Kimura E, Kubo K, Nakajima K, Kakeyama M and Tohyama C
- Organizer
  環境ホルモン学会第16回研究発表会
- Place of Presentation
  東京大学　（東京都文京区）
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] AhRシグナルの活性化は発達期脳における海馬CA1錐体細胞の樹状突起成長を制御している2013
- Author(s)
  木村栄輝、松吉智瑛里、宮崎航、久保健一郎、遠藤俊裕、凌文てい、仲嶋一範、掛山正心、遠山千春
- Organizer
  Neuro2013 (第36回日本神経科学大会)
- Place of Presentation
  京都府京都市
- Data Source
  KAKENHI-PROJECT-24221003
[Presentation] IntelliCage による Social Dominanceの評価2012
- Author(s)
  ベナー聖子、遠藤のぞみ、遠藤俊裕、遠山千春、掛山正心
- Organizer
  第17回日本行動神経内分泌研究会全国集会
- Place of Presentation
  京都市、関西セミナーハウス
- Year and Date
  2012-08-30
- Data Source
  KAKENHI-PROJECT-24651059
[Presentation] 周産期低用量TCDD曝露マウスにおける恐怖情動性の行動学的評価2012
- Author(s)
  ベナー聖子、〓島旭、小早川令子、小早川高、掛山正心、遠山千春
- Organizer
  環境ホルモン学会第15回研究発表会
- Place of Presentation
  東京、東京大学山上会館
- Year and Date
  2012-12-18
- Data Source
  KAKENHI-PROJECT-24651059
[Presentation] マウス行動試験法を用いた発達期ストレスの社会性影響評価2012
- Author(s)
  ベナー聖子、掛山正心、遠山千春
- Organizer
  第82回日本衛生学会学術総会
- Place of Presentation
  京都大学(京都府)
- Year and Date
  2012-03-25
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Assessment of advanced cognitive behaviors in rodents : Maternal exposure to dioxin causes psychobehavioral abnormality and learning defecits2011
- Author(s)
  Tohyama C, Kakeyama M.
- Organizer
  The 7th Congress of the Federations of Asian and Oceanian Physiological Societies
- Place of Presentation
  台北、台湾
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Assessment of advanced cognitive behaviors in rodents : maternal exposure to dioxin causes psychobehavioral abnormality and learning deficits2011
- Author(s)
  Tohyama C, Kakeyama M
- Organizer
  the 7th Congress of the Federations of Asian and Oceanian Physiological Societies (FAOPS)
- Place of Presentation
  NTUH Convention Center台北(台湾)(招待講演)
- Year and Date
  2011-09-13
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Corridor shuttling spatial learning task[ 1]: Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system2010
- Author(s)
  Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
- Organizer
  40th Annual meeting of Society for Neuroscience
- Place of Presentation
  San Diego, USA
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Corridor shuttling spatial learning task[1] : Automated analysis of behavioral flexibility and reversal learning-set in mice using IntelliCage system.2010/10, San Diego.2010
- Author(s)
  Endo T, Maekawa F, Voikar V, Haijima A, Uemura Y, Zhang Y, Miyazaki W, Suyama S, Shimazaki K, Wofler DP, Yada T, Tohyama C, Lipp HP, Kakeyama M.
- Organizer
  40th Annual meeting of Society for Neuros cience
- Place of Presentation
  San Diego (USA)
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 実験動物高次脳機能評価法の今後展開2010
- Author(s)
  掛山正心・遠山千春
- Organizer
  環境ホルモン学会第13回研究発表会
- Place of Presentation
  東京大学山上会館(東京都)
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 『環境ホルモン』問題の現状と今後の課題2010
- Author(s)
  遠山千春
- Organizer
  松本大学特別講演会
- Place of Presentation
  松本大学(長野県)
- Year and Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Perinatal TCDD exposure induce learning and affective behavioral deficits in adult male mice : Its low-dose specificity and the possible causal brain regions2010
- Author(s)
  Endo T, Tohyama C, Kakeyama M.
- Organizer
  49th Annual meeting of Society of Toxicology(SOT)
- Place of Presentation
  Salt Lake City、USA
- Year and Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 実験動物高次脳機能評価法の今後の展開2010
- Author(s)
  掛山正心・遠山千春
- Organizer
  環境ホルモン学会第13回研究発表会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Perinatal TCDD exposure induce learning and affective behavioral deficits in adult male mice : Its low-dose specificity and the possible causal brain regions2010
- Author(s)
  Endo T, Tohyama C, Kakeyama M
- Organizer
  49^<th> Annual meeting of Society of Toxicology(SOT)
- Place of Presentation
  Salt Lake City U.S.A
- Year and Date
  2010-03-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 『環境ホルモン』問題の現状と今後の課題2010
- Author(s)
  遠山千春
- Organizer
  松本大学特別講演会
- Place of Presentation
  松本大学長野県
- Year and Date
  2010-02-05
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 胎仔期・授乳期の低用量ダイオキシン曝露が情動機能に及ぼす影響:低用量特異的影響と用量依存的影響2010
- Author(s)
  配島旭・張艶・遠藤俊裕・掛山正心・遠山千春
- Organizer
  環境ホルモン学会第13回研究発表会
- Place of Presentation
  東京大学(東京都)
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 日本衛生学会賞受賞講演「環境と健康・・・衛生学徒の毒性学」2010
- Author(s)
  遠山千春
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 胎仔期・授乳期の低用量ダイオキシン曝露が情動機能に及ぼす影響:低用量特異的影響と用量依存的影響2010
- Author(s)
  〓島旭・張艶・遠藤俊裕・掛山正心・遠山千春
- Organizer
  環境ホルモン学会第13回研究発表会
- Place of Presentation
  東京大学山上会館(東京都)
- Year and Date
  2010-12-16
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 日本衛生学会賞講演「環境と健康・・・衛生学徒の毒性学」2010
- Author(s)
  遠山千春
- Organizer
  第80回日本衛生学会学術総会
- Place of Presentation
  仙台国際センター(宮城県)
- Year and Date
  2010-05-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Corridor shuttling spatial learning task[ 2]: Chemically-induced emotional dysfunctions in group-housed mice as an animal model of perseveration and social anxiety2010
- Author(s)
  Kakeyama M, Endo T, Tohyama C.
- Organizer
  40th Annual meeting of Society for Neuroscience
- Place of Presentation
  San Diego. USA
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Corridor shuttling spatial learning task[2] : Chemically-induced) emotional dysfunctions in group-housed mice as an animal model of perseveration and social anxiety.2010
- Author(s)
  Kakeyama M, Endo T, Tohyama C.
- Organizer
  40th Annual meeting of Society for Neuros cience
- Place of Presentation
  San Diego (USA)
- Year and Date
  2010-10-17
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 集団型全自動マウス行動特性評価法の構築:周産期低用量TCDD曝露マウスを用いた行動毒性試験への応用2009
- Author(s)
  遠藤俊裕、掛山正心、遠山千春
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  盛岡市民文化ホール(岩手県)
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 内分泌かく乱化学物質のリスク研究と公衆衛生2009
- Author(s)
  遠山千春
- Organizer
  第68回日本公衆衛生学会総会
- Place of Presentation
  奈良県文化会館(奈良県)
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 集団型全自動マウス行動特性評価法の構築:周産期低用量TCDD曝露マウスを用いた行動毒性試験への応用2009
- Author(s)
  遠藤俊裕、掛山正心、遠山千春
- Organizer
  第36回日本トキシコロジー学会学術年会
- Place of Presentation
  盛岡市民文化ホール岩手県
- Year and Date
  2009-07-07
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice.2009
- Author(s)
  Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
- Organizer
  29th International Symposium on Halogenated Persistent Organic Pollutants(Dioxin2009)
- Place of Presentation
  Beijing China
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] Perinatal exposure to a low-dose of dioxin induces deficits in fear conditioning in mice2009
- Author(s)
  Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
- Organizer
  29th International Symposium on Halogenated Persistent Organic Pollutants
- Place of Presentation
  北京、中国
- Year and Date
  2009-08-23
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] In utero and lactational exposure to dioxins induces deficits in fear conditioning in mice2009
- Author(s)
  Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
- Organizer
  5th International Congress of Asian Society of Toxicology
- Place of Presentation
  台北、台湾
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 内分泌かく乱化学物質のリスク研究と公衆衛生2009
- Author(s)
  遠山千春
- Organizer
  第68回日本公衆衛生学会総会
- Place of Presentation
  奈良県文化会館奈良県
- Year and Date
  2009-10-22
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] In utero and lactational exposure to dioxins induces deficits in fear conditioning in mice.2009
- Author(s)
  Haijima A, Endo T, Zhang Y, Kakeyama M, Tohyama C.
- Organizer
  5th International Congress of Asian Society of Toxicology
- Place of Presentation
  Taipei Taiwan
- Year and Date
  2009-09-10
- Data Source
  KAKENHI-PROJECT-21390186
[Presentation] 環境ホルモン研究の現状---低用量影響とエピジェネティックス
- Author(s)
  遠山千春
- Organizer
  ダイオキシン・環境ホルモン国民会議講演会
- Place of Presentation
  エコギャラリー新宿　東京都
- Invited
- Data Source
  KAKENHI-PROJECT-24221003

1. KAKEYAMA Masaki (30353535)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
2. NAKAJIMA Kazunori (90280734)

# of Collaborated Projects: 1 results

# of Collaborated Products: 8 results
3. MAEKAWA Fumihiko (40382866)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
4. KIMURA Eiki (90710054)

# of Collaborated Projects: 1 results

# of Collaborated Products: 19 results
5. SHIMOJO Nobuhiro (00080622)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. TSUTUMI Osamu (60134574)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SATOH Masahiko (20256390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. YONEMOTO Junzo (30072664)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
9. AOKI Yasunobu (20159297)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. OHSAKO Seiichiro (00274837)

# of Collaborated Projects: 1 results

# of Collaborated Products: 15 results
11. NISHIMURA Noriko (10097800)

# of Collaborated Projects: 1 results

# of Collaborated Products: 9 results
12. 佐藤洋 (40125571)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 永沼章 (80155952)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. 藤田博美 (60142931)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 小野坂敏見 (20068274)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. 吉田稔 (80081660)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. 渡辺知保 (70220902)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HOMMA Shino

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. KUBO Ken-Ichiro

# of Collaborated Projects: 0 results

# of Collaborated Products: 2 results
20. MIYAZAKI Wataru

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Tohyama Chiharu 遠山 千春

TOHYAMA Chiharu 遠山 千春

Research Projects

Research Products

Co-Researchers

Establishment of test method to detect developmental disorders in juvenile animal models by environmental factorsPrincipal Investigator

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Elucidation of mechanisms of developmental neurotoxicity by micro-morphological analysisPrincipal Investigator

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in vivo解析によるダイオキシン発達神経毒性メカニズムの解明Principal Investigator

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Developmental toxicity of the neuroendocrine stress response system caused by environmental chemicalsPrincipal Investigator

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Elucidation of developmental neurotoxicity mechanisms of polycyclic aromatic hydrocarbons via aryl hydrocarbon receptorPrincipal Investigator

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亜鉛欠乏による毒性感受性遺伝子への胎生期エピジェネティックプログラミングの解析Principal Investigator

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The profiling of gene expression evoked by co-exposure to dioxin and polychlorinated biphenyl.Principal Investigator

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重金属中毒学のパラダイムシフト

Principal Investigator

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Physiological significance of metallothionein on environmental carcinogenesisPrincipal Investigator

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ANALYSIS OF ENDOCRINE DISRUPTORS AFFECTING REPRODUCTIVE FUNCTION

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NEW METHODOLOGY FOR EVALUATION OF RENAL DAMAGE CAUSED BY HEAVY METALS ON THE TUBULAR LEVELPrincipal Investigator

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[Journal Article] Embryonic and postnatal expression of aryl hydrocarbon receptor mRNA in mouse brain2017

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[Journal Article] Excessive activation of AhR signaling disrupts neuronal migration in the hippocampal CA1 region in the developing mouse2017

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Tohyama Chiharu 遠山千春

TOHYAMA Chiharu 遠山千春