OKU Naoto 奥直人

… Alternative Names

奥直人オクナオト

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Researcher Number	10167322
Other IDs
External Links
Affiliation (Current)	2025: 静岡県立大学, 薬学部, 特任教授
Affiliation (based on the past Project Information) *help	2020 – 2023: 帝京大学, 薬学部, 教授 2018 – 2019: 静岡県立大学, 薬学部, 特任教授 2018 – 2019: 帝京大学, 薬学部, 特任教授 2018: 帝京大学, 薬学部, 教授 1998 – 2017: 静岡県立大学, 薬学部, 教授 … More 1993 – 1997: 静岡県立大学, 薬学部, 助教授 1993: 静岡大学, 薬学部, 助教授 1992: 静岡大, 薬学部, 助教授 1991: 慶應義塾大学, 薬学部, 助教授 1991: University of Shizuoka, School of Pharmaceutical Sciences, Associate professor, 薬学部, 助教授 1988 – 1990: 摂南大学, 薬学部, 助教授 1986: 摂南大学, 薬学部, 講師 Less
Review Section/Research Field	Principal Investigator Physical pharmacy / 医薬分子機能学 / Medical pharmacy / Biological pharmacy / Biological Sciences Except Principal Investigator Biological pharmacy / Emergency medicine / Ophthalmology / General surgery / Basic Section 47030:Pharmaceutical hygiene and biochemistry-related … More / Basic Section 90120:Biomaterials-related / Medium-sized Section 47:Pharmaceutical sciences and related fields / Basic Section 90110:Biomedical engineering-related / Physical pharmacy / Drug development chemistry Less
Keywords	Principal Investigator リポソーム / DDS / 薬物送達システム / がん治療 / 血管新生 / 標的化 / 新生血管 / ナノ粒子 / 脳梗塞 / 薬物送達 … More / 虚血性疾患 / ドラッグデリバリー / ターゲティング / アクティブターゲティング / Targeting / Liposome / Angiogenesis / Cancer / 腫瘍 / ポジトロンCT (PET) / ポジトロンCT(PET) / cancer therapy / drug delivery system / liposomes / 血中滞留性リポソーム / 癌治療 / TNF / ファスジル / ＤＤＳ / アシアロエリスロポエチン / 細胞保護効果 / アレルギー / 逆標的化 / 腫瘍新生血管傷害療法 / ファージディスプレイライブラリー / ＭＭＰ / 脳出血抑制 / ＰＤＧＦ / 血栓溶解剤 / 治療可能時間 / 脳血管障害 / 脳血管疾患 / 組織プラスミノーゲン活性化因子 / 脳梗塞治療 / 解毒 / 人工抗体 / 中和活性 / 毒素 / ポリマーリガンド / ポリマー粒子 / 膜流動性 / 毒素の中和 / ヒストン / 敗血症 / プラスチック抗体 / ノンインプリント人工抗体 / autoimmune disease / allergy / desensitization / liposome / active targeting / reverse targeting / リボソーム / 自己免疫疾患 / 減感作 / Photodynamic Therapy / Active Targeting / Drug Delivery System (DDS) / Antineovascular Therapy / Drug delivery system / Phage displayed library / Cancer treatment / Neovessel / metastasis suppresion / macrophage / integrin / selectin / imaging / cell trafficking / positron emission tomography (PET) / metastasis / シアリルルイスX / スルファチド / NR細胞 / シアリルルイスA / 免疫監視機構 / 転移標的組織 / 転移抑制 / マクロファージ / インテグリン / セレクチン / イメージング / 細胞交通 / がん転移 / laser / long circulating liposomes / positron CT (PET) / benzoporphyrin / photodynamic therapy (PDT) / レーザー / ベンゾポルフィリン / 癌光化学治療(PDT) / long-curculating liposomes / reticuloendothelial system / 抗腫瘍 / 温度感受性 / RES回避 / 細網内皮系 / Signal Transduction / G-protein / Prostaglandin / Cellular Growth / Cytotoxicity / Tumor Necrosis Factor / 情報伝達機構 / Gタンパク質 / プロスタグランジン / 細胞増殖 / 細胞傷害 / 腫瘍壊死因子 / 新生血管標的化 / ドキソルビシン / 併用療法 / 腫瘍血管新生 / miR-499 / miR499 / TEPA-PCL / 血管正常化 / マイクロRNA / ポリカチオンリポソーム / RNA干渉 / 核酸医薬品 / バイオパニング / ファージディスプレイペプチドライブラリー / 長期血中滞留性 / 薬学 / 行動薬理 / エリスロポエチン / タクロリムス / ＰＥＴ / 運動機能 / 脳保護薬 / 虚血再灌流障害 / 脳虚血再灌流障害 / ナノ粒 / タムスロシン / Cryjl / Cryj 1 / Cryj1 / ABC現象 / 免疫疾患 / 花粉症 / 複標的化 / 2D-DIGE / 膵がんモデル … More Except Principal Investigator ナノ粒子 / リポソーム / イメージング / 老化 / ヘモグロビン / 酸化ストレス / がん / 抗体 / 分子認識 / ドラッグデリバリー / Rhoキナーゼ阻害剤 / ファスジル / Rho-キナーゼ阻害剤 / 薬物送達学 / 加齢黄斑変性 / Na^+ / 癌転移 / UVC / UVB / ペプチド / 再灌流障害 / 人工酸素運搬体 / 内呼吸 / 外呼吸 / 酸素 / インテグリン / リポソ-ム / 遺伝子導入 / 食品 / 認知症 / 消化吸収 / シアル酸 / シアリダーゼ / 吸着剤 / 解毒剤 / アミノ酸 / 毒素 / 脂質二重膜小胞 / mRNA / 取り込み / 細胞外小胞 / 薬物送達 / エクソソーム / 腎不全 / N-Isopropylacrylamide / 経口投与 / 体内動態 / 潰瘍性大腸炎 / 多価効果 / 腎疾患 / 糖尿病 / 合成高分子 / ドラッグデリバリーシステム / 脈絡膜新生血管 / 循環 / 臓器虚血 / 抗炎症作用 / アポトーシス / 虚血再灌流障害 / 一酸化炭素 / ドラックデリバリー / Fasudil / Ｆａｓｕｄｉｌ / Ｒｈｏキナーゼ阻害剤 / APRPG修飾リポソーム / ドラッグディバリーシステム / Dibucaine / Lidocaine / Anesthetics / Transport of ions / Amiloride / Reconstitution / Liposome / H^+ antiporter / H^+アンチポーター / ジブカイン / リドカイン / 麻酔薬 / イオン輸送 / アミロライド / 再構成 / Na^+@H^+アンチポ-タ- / Metastasis / Stress protein / memory / Learning / Green tea catechins / Brain / Oxidative stress / Senescence-accelerated mice / Aging / Hsp / がん転移 / ストレス蛋白質 / 学習・記憶 / 緑茶カテキン / 脳 / 老化促進モデルマウス / Gene therapy / Biosurfactant / Endocytosis / Microscopy / Non-viral vector / Cationic liposome / Cationic cholesterol / Gene transfection / 膜融合 / 非ウイルスベクター / 遺伝子治療 / バイオサーファクタント / エンドサイトーシス / 顕微光学法 / 非ウィルスベクター / 正電荷リポソーム / 正電荷コレステロール / laser / cancer therapy / long circulating liposomes / anti-metastasis / diagnostic imaging / positron CT (PET) / cancer metastasis / ポジトロンCT (PET) / セレクチン / シアリルルイスX / RGD / 転移抑制 / 画像診断 / ポジトロンCT(PET) / DNA repair / dimethyl arsine / active oxygen / pyrimidine dimer / DNA strand breaks / DNA damage / 過酸化ラジカル / 活性酵素 / ピリミジンニ量体 / DNA一重鎖切断 / ジメチル砒素 / DNA修復 / ジメチル石素 / 活性酸素 / ピリミジンダイマー / DNA切断 / 遺伝子傷害 / VVC / Urgent Work / Prince Khaemwaset, / Ramesses II, / New Kingdom, / Necropolis, / North Saqqara, / Abusir South, / Egypt, / modeling / domain / cross-linking / protein / cell surface / binding / platelet / heparin / 解析 / 分子レベル / 相互作用 / カエムワセト王子 / 移籍の緊急保全 / ラメセス2世 / 新王国時代 / ネクロポリス / 北サッカラ / アブ・シール南 / エジプト / 架橋化剤 / 結合ドメイン / モデリング / ドメイン / 架橋 / 蛋白質 / 細胞表層 / 結合 / 血小板 / ヘパリン / リチウムイオンとリン酸化反応 / A-431細胞 / 細胞形態 / 上皮増殖因子 / 細胞増殖因子 / フルオラス化学 / PEG化医薬品 / 体内動態解析 / フッ素化 / Huisgen反応 / PEG / 蛍光色素 / フッ素アニオン / 創薬 / ＰＥＧ化医薬品 / クリック化学 / ポリエチレングリコール / 再還流障害 / 人工酸素運搬対 / 水素 / シアン中毒 / 一酸化炭素中毒 / 酸素代謝障害 / 虚血 / 薬理学 / エネルギー代謝 / 救急 / 救命 / ナノバイオ / 酸素ラジカル / 虚血・再還流 / 創傷治癒 / 脳梗塞 / 微小循環 / 人工赤血球 / 救急蘇生学 / 増殖因子 / 基質分解酵素 / カドヘリン / 転移の臓器特異性 / 接着分子 / 癌の転移 / 細網内皮系 / ドラッグデリバリ- / モノクロ-ナル抗体(B4G7) / 低アフィニティ-タイプ / イムノトキシン療法 / 上皮増殖因子受容体(EGFR) / リガンド結合型接合体 / 抗体結合型接合体 / 癌細胞 / 殺細胞効果 / 固相法 / 扁平上皮癌 / イムノジーン / イムノトキシン / 接合体 / ドラッグデリバリー・システム(DDS) / モノクローナル抗体(B4G7) / 上皮増殖因子レセプター(EGFR) Less

老化脳に蓄積する神経障害性非ヒト型シアル酸の発見に基づく革新的認知症対策の構築
- Principal Investigator
  
  南彰
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
- Research Institution
  University of Shizuoka
Exploration of highly functional exosomes using a continuous media recovery system and its application to drug delivery
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2022 – 2023
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 47:Pharmaceutical sciences and related fields
- Research Institution
  University of Shizuoka
Development of biomimetic nano-antibody that neutralizes target molecules in blood for cancer therapy
- Principal Investigator
  
  小出裕之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90120:Biomaterials-related
- Research Institution
  University of Shizuoka
Development of plastic antibodies that inhibit intestinal absorption of target molecules
- Principal Investigator
  
  Koide Hiroyuki
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 90110:Biomedical engineering-related
- Research Institution
  University of Shizuoka
Development of new eye drop treatment using liposomal delivery system for age-related macular degeneration.
- Principal Investigator
  
  Honda Miki
- Project Period (FY)
  2016 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Juntendo University
Development of liposomal plastic antibody for novelDDS and applicaion for sepsis treatmentPrincipal Investigator
- Principal Investigator
  
  Oku Naoto
- Project Period (FY)
  2016 – 2017
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of FA-Snap, a smart DDS drug, for proposing an innovative therapeutic modality of ischemic stroke.Principal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Teikyo University
  University of Shizuoka
Experimental approach to respiratory and circulatory failure using artificial oxygen carriers and their derivatives
- Principal Investigator
  
  KAWAGUCHI Akira
- Project Period (FY)
  2015 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Novel strategy of tumor treatiment via the normalization of tumor vasculature by microRNAPrincipal Investigator
- Principal Investigator
  
  Oku Naoto
- Project Period (FY)
  2014 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Innovative Approaches for Oxygen Metabolism Disorder with Artificial Oxygen Carriers and Related Compounds
- Principal Investigator
  
  KAWAGUCHI Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Innovation of a novel technology for supporting the development of DDS drugs and protein medicines by controling their pharmacokinetics.Principal Investigator
- Principal Investigator
  
  OKU NAOTO
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Synthesis of PEGylated drug candidates for PET imaging
- Principal Investigator
  
  AKAI Shuji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Drug development chemistry
- Research Institution
  Osaka University
  University of Shizuoka
Developent of new drug delivery system using targeted liposomes for age-related macular degeneration
- Principal Investigator
  
  Honda Miki
- Project Period (FY)
  2012 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Ophthalmology
- Research Institution
  Juntendo University
New development of diagnostic and therapeutic modality for ischemia/reperfusion injury by intelligent DDSPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2011 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of novel nanoparticles for DDS, and establishment of Therapeutic modality for brain ischemia by use of these nanoparticles.Principal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2010 – 2011
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
難治がんの克服を目標した発展型腫瘍新生血管標的化DDSに関する研究Principal Investigator
- Principal Investigator
  
  奥直人
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Shizuoka
Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements
- Principal Investigator
  
  KAWAGUCHI Akira
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
A novel targeting DDS for the treatment of autoimmune diseases and allergyPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  University of Shizuoka
Development of Radical Treatment Modality for Curing Allergies and Immune Diseases by a Novel Consept, RTDDSPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  University of Shizuoka
難治がんの克服を目標とした腫瘍新生血管標的化DDSに関する包括的研究Principal Investigator
- Principal Investigator
  
  奥直人
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  University of Shizuoka
Establishment of Antineovascular Therapy by use of Structure-recognizing targeting probesPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Medical pharmacy
- Research Institution
  UNIVERSITY OF SHIZUOKA
接着分子の制御による癌転移の抑制
- Principal Investigator
  
  松浦成昭
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Osaka University
Angiogenesis Suppression and Cancer Treatment by Use of Neovascular Targeted ProbePrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  医薬分子機能学
- Research Institution
  University of Shizuoka
Gene transfection by cationic liposome with a cationic cholesterol derivative
- Principal Investigator
  
  NAKANISHI Mamoru
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Physical pharmacy
- Research Institution
  Nagoya City University
Role of Stress Proteins in Protection from Cancer Metastasis and Aging
- Principal Investigator
  
  UNNO Keiko
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
腫瘍標的化リポソームを用いたがん治療法の開発Principal Investigator
- Principal Investigator
  
  奥直人
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (A)
- Research Institution
  University of Shizuoka
Non-invasive in vivo analysis of early metastatic processesPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  1997 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  University of Shizuoka
Development of anti-metastatic agents related to the early event of metastasis : screened by novel imaging thchnique.
- Principal Investigator
  
  OKADA Shoji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biological pharmacy
- Research Institution
  UNIVERSITY OF SHIZUOKA
Cancer Photodynamic Therapy by use of RES-avoiding LiposomesPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  UNIVERSITY OF SHIZUOKA
Joint Research for Heparin-Platelet Interaction
- Principal Investigator
  
  SUDA Yasuo, YOSHIMURA Sakuji
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Overseas Scientific Survey.
- Research Institution
  Osaka University
  Waseda University
Effect of peroxide radicals on UVB-induced DNA damage
- Principal Investigator
  
  OKADA Shoji
- Project Period (FY)
  1994 – 1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Biological pharmacy
- Research Institution
  UNIVERSITY OF SHIZUOKA
DEVELOPMENT OF FUNCTIONAL RES-AVOIDING LIPOSOMES AND THEIR USE IN CANCER THERAPYPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  医薬分子機能学
- Research Institution
  UNIVERSITY OF SHIZUOKA
増殖因子受容体を標的とする新しいDDSの開発と実用化の試み
- Principal Investigator
  
  清水信義
- Project Period (FY)
  1991 – 1993
- Research Category
  
  Grant-in-Aid for Developmental Scientific Research (B)
- Research Field
  
  General surgery
- Research Institution
  Keio University
Study of the Signal Transduction of and Cellular Response (Growth Stimulation and Cytotoxicity) to Tumor Necrosis FactorPrincipal Investigator
- Principal Investigator
  
  OKU Naoto
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  UNIVERSITY OF SHIZUOKA
  Setsunan University
RECONSTITUTION OF THE Na^+/H^+ ANTIPORTER IN LIPOSOMES
- Principal Investigator
  
  ITO Fumiaki
- Project Period (FY)
  1988 – 1989
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  SETSUNAN UNIVERSITY
細胞形態変化を指標とした細胞増殖因子のシグナル伝達機構の解明
- Principal Investigator
  
  伊藤文昭
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Biological pharmacy
- Research Institution
  Setsunan University

[Book] Brain Tumor Diagnosis Using PET with Angiogenic Vessel-Targeting Liposomes."Tumors of the Centra Nervous System volume3 Brain Tumors"(Part 1)2011
- Author(s)
  Kosuke Shimizu, Naoto Oku
- Publisher
  Springer London
- Data Source
  KAKENHI-PROJECT-22659010
[Book] Tumors of the Centra Nervous System volume3 Brain Tumors2011
- Author(s)
  K.Shimizu, N.Oku
- Total Pages
  8
- Publisher
  Springer London
- Data Source
  KAKENHI-PROJECT-22659010
[Book] Methods in Enzymology, 391 (N.Duzugunes ed.)2005
- Author(s)
  Naoto Oku, et al.
- Publisher
  Elsevier Academic Press
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Cooling-induced, localized release of cytotoxic peptides from engineered polymer nanoparticles in living mice for cancer therapy2023
- Author(s)
  Koide Hiroyuki、Saito Kazuhiro、Yoshimatsu Keiichi、Chou Beverly、Hoshino Yu、Yonezawa Sei、Oku Naoto、Asai Tomohiro、Shea Kenneth J.
- Journal Title
  
  Journal of Controlled Release
  
  Volume: 355 Pages: 745-759
- DOI
  10.1016/j.jconrel.2023.02.020
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-22K19384, KAKENHI-ORGANIZER-22H05047, KAKENHI-PLANNED-22H05048, KAKENHI-PROJECT-22K19940, KAKENHI-PLANNED-22H05051, KAKENHI-PROJECT-23K25211
[Journal Article] Treatment of PTEN-Null Breast Cancer by a Synthetic Lethal Approach Involving PARP1 Gene Silencing2023
- Author(s)
  Asai Tomohiro、Yokota Masafumi、Isomura Hideki、Koide Hiroyuki、Sakurai Naoyuki、Okamoto Ayaka、Ando Hidenori、Dewa Takehisa、Oku Naoto
- Journal Title
  
  Journal of Pharmaceutical Sciences
  
  Volume: - Issue: 7 Pages: 1908-1914
- DOI
  10.1016/j.xphs.2023.02.017
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22K19384, KAKENHI-PROJECT-23K25211, KAKENHI-PROJECT-22K19940, KAKENHI-PROJECT-23K24016
[Journal Article] Enhancement of target toxin neutralization effect in?vivo by PEGylation of multifunctionalized lipid nanoparticles2021
- Author(s)
  Koide Hiroyuki、Suzuki Hikaru、Ochiai Hiroki、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 555 Pages: 32-39
- DOI
  10.1016/j.bbrc.2021.03.073
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Synthetic hydrogel nanoparticles for sepsis therapy2021
- Author(s)
  Koide Hiroyuki、Okishima Anna、Hoshino Yu、Kamon Yuri、Yoshimatsu Keiichi、Saito Kazuhiro、Yamauchi Ikumi、Ariizumi Saki、Zhou Yuqi、Xiao Ting-Hui、Goda Keisuke、Oku Naoto、Asai Tomohiro、Shea Kenneth J.
- Journal Title
  
  Nature Communications
  
  Volume: 12 Issue: 1 Pages: 5552-5552
- DOI
  10.1038/s41467-021-25847-2
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450, KAKENHI-PROJECT-21J10990
[Journal Article] Influence of Purification Process on the Function of Synthetic Polymer Nanoparticles2021
- Author(s)
  Yasuno Go、Koide Hiroyuki、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Chemical and Pharmaceutical Bulletin
  
  Volume: 69 Issue: 8 Pages: 773-780
- DOI
  10.1248/cpb.c21-00273
- NAID
  130008070212
- ISSN
  0009-2363, 1347-5223
- Year and Date
  2021-08-01
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Design of abiotic polymer ligand-decorated lipid nanoparticles for effective neutralization of target toxins in the blood2021
- Author(s)
  Koide Hiroyuki、Yamauchi Ikumi、Hoshino Yu、Yasuno Go、Okamoto Takumi、Akashi Sotaro、Saito Kazuhiro、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biomaterials Science
  
  Volume: 9 Issue: 16 Pages: 5588-5598
- DOI
  10.1039/d1bm00515d
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Design of synthetic polymer nanoparticles that inhibit glucose absorption from the intestine2021
- Author(s)
  Koide Hiroyuki、Hayashi Naoki、Yasuno Go、Okishima Anna、Hoshino Yu、Egami Hiromichi、Hamashima Yoshitaka、Oku Naoto、Asai Tomohiro
- Journal Title
  
  Biochemical and Biophysical Research Communications
  
  Volume: 561 Pages: 1-6
- DOI
  10.1016/j.bbrc.2021.05.005
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Engineering of lipid nanoparticles by the multifunctionalization of the surface with amino acid derivatives for the neutralization of a target toxic peptide.2020
- Author(s)
  Koide H, Hirano S, Ide T, Saito K, Suzuki H, Yasuno G, Hamashima Y, Yonezawa S, Oku N, Asai T
- Journal Title
  
  Adv Funct Mater.
  
  Volume: 31 Issue: 3 Pages: 2005641-2005641
- DOI
  10.1002/adfm.202005641
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20K21905, KAKENHI-PROJECT-19H04450
[Journal Article] Engineering the Binding Kinetics of Synthetic Polymer Nanoparticles for siRNA Delivery2019
- Author(s)
  Hiroyuki Koide, Tatsuya Fukuta, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Hiroki Tsuchida, Masahiko Nakamoto, Keiichi Yoshimatsu, Hidenori Ando, Takehisa Dewa, Tomohiro Asai, Naoto Oku, Yu Hoshino, Kenneth J. Shea
- Journal Title
  
  Biomacromolecules
  
  Volume: 20 Issue: 10 Pages: 3648-3657
- DOI
  10.1021/acs.biomac.9b00611
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Journal Article] Macrophage-targeted, enzyme-triggered fluorescence switch-on system for detection of embolism-vulnerable atherosclerotic plaques.2019
- Author(s)
  Narita Y, Shimizu K, Ikemoto K, Uchino R, Kosugi M, Maess MB, Magata Y, Oku N, Ogawa M.
- Journal Title
  
  J. Control. Release
  
  Volume: 302 Pages: 105-115
- DOI
  10.1016/j.jconrel.2019.03.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16H05081, KAKENHI-PROJECT-15H02569
[Journal Article] Applications of Liposomal Drug Delivery Systems to Develop Neuroprotective Agents for the Treatment of Ischemic Stroke2019
- Author(s)
  Fukuta T, Ishii T, Asai T, Oku N.
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 42 Issue: 3 Pages: 319-326
- DOI
  10.1248/bpb.b18-00683
- NAID
  130007606450
- ISSN
  0918-6158, 1347-5215
- Year and Date
  2019-03-01
- Language
  English
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16H05081, KAKENHI-PROJECT-17H06906, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15H02569
[Journal Article] Co-administration of liposomal fasudil and tissue plasminogen activator ameliorated ischemic brain damage in occlusion model rats prepared by photochemically induced thrombosis.2018
- Author(s)
  Fukuta T, Yanagida Y, Asai T, Oku N
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 495 Issue: 1 Pages: 873-877
- DOI
  10.1016/j.bbrc.2017.11.107
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Propofol induces nuclear localization of Nrf2 under conditions of oxidative stress in cardiac H9c2 cells2018
- Author(s)
  Shinjo T, Tanaka T, Okuda H, Kawaguchi AT, Ohhashi K, Terada Y, Isonishi A ,Morita-Takemura S, Tatsumi K, Kawaguchi M, Wanaka A.
- Journal Title
  
  PLOS ONE
  
  Volume: ー
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Process optimization by use of design of experiments: Application for liposomalization of FK5062017
- Author(s)
  Toyota H, Asai T, Oku N
- Journal Title
  
  Eur. J. Pharm. Sci
  
  Volume: 102 Pages: 196-202
- DOI
  10.1016/j.ejps.2017.03.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Inducibility of Ventricular Arrhythmia 1 Year Following Treatment with Heavy Ion Irradiation in Dogs with Myocardial Infarction.2017
- Author(s)
  Amino M, Yoshioka K, Furusawa Y, Tanaka S, Kawabe N, Hashida T, Tsukada T, Izumi M, Inokuchi S, Tanabe T, Ikari Y
- Journal Title
  
  Pacing and Clinical Electrophysiology
  
  Volume: 40 Issue: 4 Pages: 379-390
- DOI
  10.1111/pace.13031
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-15K10012
[Journal Article] Targeted delivery of anticancer drugs to tumor vessels by use of liposomes modified with a peptide identified by phage biopanning with human endothelial progenitor cells2017
- Author(s)
  Fukuta T, Asai T, Kiyokawa Y, Nakada T, Bessyo-Hirashima K, Fukaya N, Hyodo K, Takase K, Kikuchi H, Oku N.
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 524 Issue: 1-2 Pages: 364-372
- DOI
  10.1016/j.ijpharm.2017.03.059
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-15H02569
[Journal Article] Novel CPR system that predicts return of spontaneous circulation from amplitude spectral area before electric shock in ventricular fibrillation.2017
- Author(s)
  Nakagawa Y, Amino M, Inokuchi S, Hayashi S, Wakabayashi T, Noda T.
- Journal Title
  
  Resuscitation
  
  Volume: 113 Pages: 8-12
- DOI
  10.1016/j.resuscitation.2016.12.025
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Combination therapy with liposomal neuroprotectants and tissue plasminogen activator for treatment of ischemic stroke.2017
- Author(s)
  Fukuta T, Asai T, Yanagida Y, Namba M, Koide H, Shimizu K, Oku N.
- Journal Title
  
  The FASEB Journal
  
  Volume: 印刷中 Issue: 5 Pages: 1879-1890
- DOI
  10.1096/fj.201601209r
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Detection of synthetic cannabinoids using GC-EI-MS, positive GC-CI-MS, and negative GC-CI-MS.2017
- Author(s)
  Umebachi R, Saito T, Aoki H, Namera A, Nakamoto A, Kawamura M, Inokuchi S.
- Journal Title
  
  International Journal of Legal Medicine
  
  Volume: 131 Issue: 1 Pages: 143-152
- DOI
  10.1007/s00414-016-1428-y
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] A polymer nanoparticle with engineered affinity for a vascular endothelial growth factor (VEGF165)2017
- Author(s)
  Hiroyuki Koide,Keiichi Yoshimatsu,Yu Hoshino,Shih-Hui Lee,Ai Okajima,Saki Ariizumi, Yudai Narita,Yusuke Yonamine,Adam C. Weisman,Yuri Nishimura,Naoto Oku,Yoshiko Miura,Kenneth J. Shea
- Journal Title
  
  Nature Chemistry
  
  Volume: 9 Issue: 7 Pages: 715-722
- DOI
  10.1038/nchem.2749
- Peer Reviewed / Acknowledgement Compliant / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H03818, KAKENHI-PROJECT-16K14007, KAKENHI-PROJECT-17K14519, KAKENHI-PROJECT-16K15111
[Journal Article] Innovations in Liposomal DDS Technology and Its Application for the Treatment of Various Diseases2017
- Author(s)
  Naoto Oku
- Journal Title
  
  Biological and Pharmaceutical Bulletin
  
  Volume: 40 Issue: 2 Pages: 119-127
- DOI
  10.1248/bpb.b16-00857
- NAID
  130005308411
- ISSN
  0918-6158, 1347-5215
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] 脳梗塞治療におけるリポソームDDS製剤の有用性2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Journal Title
  
  オレオサイエンス
  
  Volume: 17 Pages: 15-22
- NAID
  130007687705
- Data Source
  KAKENHI-PROJECT-16H05081
[Journal Article] Rational designing of an antidote nanoparticle decorated with abiotic polymer ligands for capturing and neutralizing target toxins.2017
- Author(s)
  Koide H, Tsuchida H, Nakamoto M, Okishima A, Ariizumi S, Kiyokawa C, Asai T, Hoshino Y, Oku N
- Journal Title
  
  J. Control. Release.
  
  Volume: 68 Pages: 335-342
- DOI
  10.1016/j.jconrel.2017.10.028
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16K15111
[Journal Article] 脳梗塞治療におけるリポソームDDS製剤の有用性　(総説)2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Journal Title
  
  オレオサイエンス
  
  Volume: 17 Pages: 359-366
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Non-invasive evaluation of neuroprotective drug candidates for cerebral infarction by PET imaging of mitochondrial complex-1 activity2016
- Author(s)
  Tatsuya Fukuta, Tomohiro Asai, Takayuki Ishii, Hiroyuki Koide, Chiaki Kiyokawa, Masahiro Hashimoto, Takashi Kikuchi, Kosuke Shimizu, Norihiro Harada, Hideo Tsukada, Naoto Oku
- Journal Title
  
  Scientific Reports
  
  Volume: 6 Issue: 1 Pages: 30127-30127
- DOI
  10.1038/srep30127
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-16K08201, KAKENHI-PROJECT-16H05081
[Journal Article] Neuroprotection against cerebral ischemia/reperfusion injury by intravenous administration of liposomal fasudil2016
- Author(s)
  Fukuta T, Asai T, Sato A, Namba M, Yanagida Y, Kikuchi T, Koide H, Shimizu K, Oku N.
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 506 Issue: 1-2 Pages: 129-137
- DOI
  10.1016/j.ijpharm.2016.04.046
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-15H02569, KAKENHI-PROJECT-16H05081
[Journal Article] Enhanced Efficacy of Doxorubicin by microRNA-499-Mediated Improvement of Tumor Blood Flow.2016
- Author(s)
  Okamoto A, Asai T, Ryu S, Ando H, Maeda N, Dewa T, Oku N.
- Journal Title
  
  J Clin Med.
  
  Volume: 5 Issue: 1 Pages: 10-10
- DOI
  10.3390/jcm5010010
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-15J11660, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-26670018
[Journal Article] Clinical characteristics of α-pyrrolidinovalerophenone (α-PVP) poisoning.2016
- Author(s)
  Umebachi R, Aoki H, Sugita M, Taira T, Wakai S, Saito T, Inokuchi S.
- Journal Title
  
  Clinical Toxicology
  
  Volume: 54 Issue: 7 Pages: 563-567
- DOI
  10.3109/15563650.2016.1166508
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Reduced Immunocompetent B Cells and Increased Secondary Infection in Elderly Patients With Severe Sepsis.2016
- Author(s)
  Suzuki K, Inoue S, Kametani Y, Komori Y, Chiba S, Sato T, Inokuchi S, Ogura S.
- Journal Title
  
  Shock
  
  Volume: 46 Issue: 3 Pages: 270-278
- DOI
  10.1097/shk.0000000000000619
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Decomposition of Organic Chemicals in the Air and Inactivation of Aerosol-Associated Influenza Infectivity by Photocatalysis2015
- Author(s)
  Tohru Daikoku, Masaya Takemoto, Yoshihiro Yoshida, Tomoko Okuda, Yasuaki Takahashi, Kanji Ota, Fumio Tokuoka, Akira T. Kawaguchi, Kimiyasu Shiraki
- Journal Title
  
  Aerosol and Air Quality Research
  
  Volume: 15 Pages: 1469-1484
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15H02569
[Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron-emission tomography.2014
- Author(s)
  Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N.
- Journal Title
  
  Artif Organs
  
  Volume: 38 Pages: 662-666
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24249086
[Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimmer as an antidote for cyanide poisoning.2014
- Author(s)
  Yamagiwa T, Kawaguchi AT, Saito T, Inoue S, Morita S, Watanabe K, Kitagishi H, Kano K, Inokuchi S.
- Journal Title
  
  Hum Exp Toxicol
  
  Volume: 33 Pages: 360-368
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-24249086
[Journal Article] Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.2014
- Author(s)
  Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N.
- Journal Title
  
  Brain Res.
  
  Volume: 1559 Pages: 46-54
- DOI
  10.1016/j.brainres.2014.02.007
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-25460041, KAKENHI-PUBLICLY-26102736
[Journal Article] Real-time trafficking of PEGylated liposomes in the ischemic region of ischemia model rat brain as analyzed by positron-emission tomography2014
- Author(s)
  Fukuta T, Ishii T, Asai T, Nakamura G, Tkeuchi Y, Sato A, Agato Y, Shimizu K, Akai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N.
- Journal Title
  
  Artificial Organs
  
  Volume: 38
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249086
[Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography2014
- Author(s)
  Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Asai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N
- Journal Title
  
  Artificial organs
  
  Volume: 38 Issue: 8 Pages: 662-6
- DOI
  10.1111/aor.12350
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-14J10730, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24659049, KAKENHI-PROJECT-25460041, KAKENHI-PROJECT-25461167
[Journal Article] Dynamic Analysis of Fluid Distribution in the Gastrointestinal Tract in Rats: Positron Emission Tomography Imaging after Oral Administration of Nonabsorbable Marker, [(18)F]Deoxyfluoropoly(ethylene glycol)2013
- Author(s)
  Takashima T, Shingaki T, Katayama Y, Hayashinaka E, Wada Y, Kataoka M, Ozaki D, Doi H, Suzuki M, Ishida S, Hatanaka K, Sugiyama Y, Akai S, Oku N, Yamashita S, Watanabe Y
- Journal Title
  
  Mol. Pharmaceutics
  
  Volume: 10 Issue: 6 Pages: 2261-2269
- DOI
  10.1021/mp300469m
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659049, KAKENHI-PROJECT-25242070
[Journal Article] Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors.2013
- Author(s)
  Sugiyama T, Asai T, Nedachi YM, Katanasaka Y, Shimizu K, Maeda N, Oku N.
- Journal Title
  
  PLoS One.
  
  Volume: 8 Issue: 6 Pages: e67550-e67550
- DOI
  10.1371/journal.pone.0067550
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24659021, KAKENHI-PROJECT-25460041
[Journal Article] Supramolecular ferric porphyrins and a cyclodextrin dimer as an antidote for cyanide poisoning2013
- Author(s)
  Yamagiwa T, Kawaguchi AT, Saito T, INoue S, Morita S, Watanabe K, Kitagishi H, Koji K, Inokuchi S.
- Journal Title
  
  Human and experimental toxicology
  
  Volume: Aug5 Issue: 4 Pages: 1-9
- DOI
  10.1177/0960327113499041
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25810106
[Journal Article] Treatment of cerebral ischemia-reperfusion injury with PEGylated liposomes encapsulating FK506.2013
- Author(s)
  Ishii T, Asai T, Oyama D, Agato Y, Yasuda N, Fukuta T, Shimizu K, Minamino T, Oku N.
- Journal Title
  
  FASEB J.
  
  Volume: 27 Issue: 4 Pages: 1362-1370
- DOI
  10.1096/fj.12-221325
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041
[Journal Article] Liposomes and nanotechnology in drug development: focus on ocular targets.2013
- Author(s)
  M. Honda, T. Asai, N. Oku, Y. Araki, M. Tanaka, N. Ebihara
- Journal Title
  
  Int J Nanomedicine
  
  Volume: 8 Pages: 495-504
- DOI
  10.2147/ijn.s30725
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24592679
[Journal Article] Enhanced active targeting via cooperative binding of ligands on liposomes to target receptors2013
- Author(s)
  Sugiyama T, Asai T, Nedachi YM, Katanasaka Y, Shimizu K, Maeda N, Oku N
- Journal Title
  
  PLoS One
  
  Volume: 8
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] Importance of pH in in vitro assessment of cyanide toxicity2013
- Author(s)
  Yamagiwa T, Inokuchi S, Saito T, INoue S, Morita S, Kawaguchi AT.
- Journal Title
  
  Tokai J Exp Clin Med
  
  Volume: 38 Pages: 114-122
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249086
[Journal Article] Systemic delivery of small interfering RNA by use of targeted polycation liposomes for cancer therapy.2013
- Author(s)
  Kenjo E, Asai T, Yonenaga N, Ando H, Ishii T, Hatanaka K, Shimizu K, Urita Y, Dewa T, Nango M, Tsukada H, Oku N.
- Journal Title
  
  Biol Pharm Bull.
  
  Volume: 36 Pages: 287-291
- NAID
  130003361373
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] Nanoparticles accumulate in ischemic core and penumbra region even when cerebral perfusion is reduced.2013
- Author(s)
  Ishii T, Fukuta T, Agato Y, Oyama D, Yasuda N, Shimizu K, Kawaguchi AT, Asai T, Oku N.
- Journal Title
  
  Biochem Biophys Res Commun.
  
  Volume: 430 Issue: 4 Pages: 1201-1205
- DOI
  10.1016/j.bbrc.2012.12.080
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24790047, KAKENHI-PROJECT-25460041
[Journal Article] A comparative study of cerebral microcirculation during pulsatile and nonpulsatile selective cerebral perfusion: Assessment by synchrotron radiation microangiography.2013
- Author(s)
  Inamori S, Shirai M, Yahagi N, Pearson JT, Fujii Y, Umetani K, Kobayashi Y, Okura Y, Yakehiro M, Minamiyama M.
- Journal Title
  
  ASAIO J
  
  Volume: 59 Issue: 4 Pages: 374-379
- DOI
  10.1097/mat.0b013e3182976939
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-25871231
[Journal Article] Amelioration of cerebral ischemia-reperfusion injury based on liposomal drug delivery system with asialo-erythropoietin2012
- Author(s)
  T.Ishii, T.Asai, D.Oyama, T.Fukuta, N.Yasuda, K.Shimizu, T.Minamino, N.Oku
- Journal Title
  
  Journal of Controlled Release
  
  Volume: (In press) Issue: 1 Pages: 81-87
- DOI
  10.1016/j.jconrel.2012.02.004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-10J55523, KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-23659416, KAKENHI-PROJECT-24591096, KAKENHI-PROJECT-24790047
[Journal Article] A single injection of liposomal asialo-erythropoietin improves motor function deficit caused by cerebral ischemia/reperfusion.2012
- Author(s)
  T. Ishii, T. Asai, T. Fukuta, D. Oyama, N. Yasuda, Y. Agato, K. Shimizu, T. Minamino, N. Oku
- Journal Title
  
  Int. J. Pharm.
  
  Volume: 439 Issue: 1-2 Pages: 269-274
- DOI
  10.1016/j.ijpharm.2012.09.026
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-23249005, KAKENHI-PROJECT-24790047
[Journal Article] Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles2012
- Author(s)
  H. Koide, T. Asai, H. Ando, K. Shiraishi,M. Yokoyama, and N. Oku
- Journal Title
  
  International Journal of Pharmaceutics
  
  Volume: 432 Issue: 1-2 Pages: 75-79
- DOI
  10.1016/j.ijpharm.2012.04.049
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22300170, KAKENHI-PROJECT-22790045, KAKENHI-PROJECT-24659021
[Journal Article] Size-dependent induction of accelerated blood clearance phenomenon by repeated injections of polymeric micelles2012
- Author(s)
  Koide H, Asai T, Kato H, Ando H, Shiraishi K,Yokoyama M, Oku N
- Journal Title
  
  Int J Pharm
  
  Volume: 432 Pages: 75-79
- Data Source
  KAKENHI-PROJECT-24659021
[Journal Article] T cell-independent B cell response is responsible for ABC phenomenon induced by repeated injection of PEGylated liposomes.2010
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Shuji Akai, Takayuki Ishii, Eriya Kenjo, Tatsuhiro Ishida, Hiroshi Kiwada, Hideo Tsukada, Naoto Oku
- Journal Title
  
  Int.J. of Pharmaceutics 392
  
  Pages: 218-223
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] PET imaging of brain cancer with positron emitter-labeled liposomes2010
- Author(s)
  Naoto Oku, Mina Yamashita, Yurie Katayama, Takeo Urakami, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Hideo Tsukada, Shuji Akai, Hiroaki Kanazawa
- Journal Title
  
  Int. J. Pharm
  
  Volume: 403 Pages: 170-177
- Data Source
  KAKENHI-PROJECT-22659010
[Journal Article] Accumulation of macromolecules in brain parenchyma in acute phase of cerebral infarction/reperfusion2010
- Author(s)
  Takayuki Ishii, Tomohiro Asai, Takeo Urakami, Naoto Oku
- Journal Title
  
  Brain Res
  
  Volume: 1321 Pages: 164-168
- Data Source
  KAKENHI-PROJECT-22659010
[Journal Article] In vivo Distribution of LEH determined by positron emission Tomography2009
- Author(s)
  Urakami T, Kawaguchi AT, Tsukada H, Oku N
- Journal Title
  
  Artif Organs
  
  Volume: 33 Pages: 164-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249072
[Journal Article] In vivo Distribution of LEH Determined by Positron Emission Tomography2009
- Author(s)
  (5)Urakami T, Kawaguchi AT, Tsukada H, Oku N
- Journal Title
  
  Artificial Organs 33
  
  Pages: 164-168
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249072
[Journal Article] PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明2009
- Author(s)
  小出裕之、浅井知浩、畑中剣太朗、清水広介、横山昌幸、石田竜弘、際田弘志、奥直人
- Journal Title
  
  YAKUGAKU ZASSHI 129
  
  Pages: 1445-1451
- NAID
  130000136135
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] Particle size-dependent triggering of accelerated blood clearance phenomenon.2008
- Author(s)
  Hiroyuki Koide, Tomohiro Asai, Kentaro Hatanaka, Takeo Urakami, Takayuki Ishii, Eriya Kenjo, Masamichi Nishihara, Masayuki Yokoyama, Tatsuhiro Ishida, Hiroshi Kiwada, Naoto Oku
- Journal Title
  
  Int.J.Pharm 362
  
  Pages: 197-200
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20390014
[Journal Article] Effective tumor regression by antineovascular therapy in hypovascular orthotopic pancreatic tumor model2007
- Author(s)
  S. Yonezawa, T. Asai, N. Oku
- Journal Title
  
  J. Control 118Release
  
  Pages: 303-309
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Journal Article] Antiangiogenic photodynamic therapy (PDT) by using long-circulating liposomes modified with peptide specific to angiogenic vessels2005
- Author(s)
  K.Ichikawa, N.Oku, et al.
- Journal Title
  
  Biochim.Biophy.Acta 1669
  
  Pages: 69-74
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Antineovasucular therapy, a novel antiangiogenic approach.2005
- Author(s)
  K.Shimizu, T.Asai, N.Oku
- Journal Title
  
  Expert Opin.Ther.Targets 9
  
  Pages: 63-76
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Applicability of anti-neovascular therapy to drug-resistant tumor : Suppression of drug-resistant P388 tumor growth with neovessel-targeted liposomal adriamycin.2005
- Author(s)
  K.Shimizu, T.Asai, N.Oku, et al.
- Journal Title
  
  Int.J.Pharm. 296
  
  Pages: 133-141
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Intracellular target for photosensitization in cancer antiangiogenic photodynamic therapy mediated by polycation liposome.2004
- Author(s)
  Y.Takeuchi, N.Oku, et al.
- Journal Title
  
  J. Controlled Release 97
  
  Pages: 231-240
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] In vivo trafficking of endothelial progenitor cell and their possible involvement in tumor neovascularization.2004
- Author(s)
  M.Tamura, N.Oku, et al.
- Journal Title
  
  Life Sci. 75
  
  Pages: 575-584
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Synthesis of angiogenesis-targeted peptides and hydrophobized polyethylene glycol conjugate.2004
- Author(s)
  N.Maeda, N.Oku, et al.
- Journal Title
  
  Bioorg.Med.Chem.Lett. 14
  
  Pages: 1015-1017
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Antiangionenic photodynamic therapy (PDT) using visudyne causes effective suppression of tumor growth.2004
- Author(s)
  K.Ichikawa, N.Oku, et al.
- Journal Title
  
  Cancer Lett. 205
  
  Pages: 39-48
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Cancer anti-angiogenic therapy.2004
- Author(s)
  K.Shimizu, N.Oku
- Journal Title
  
  Biol.Pharm.Bull. 27
  
  Pages: 599-605
- NAID
  110003608815
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Anti- neovasucular therapy by liposomal drug targeted to membrane type-1 matrix metalloproteinase.2004
- Author(s)
  M.Kondo, T.Asai, N.Oku, et al.
- Journal Title
  
  Int. J. Cancer 108
  
  Pages: 301-306
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Anti-neovasucular therapy by use of tumor neovasculature-targeted long-circulating liposome.2004
- Author(s)
  N.Maeda, N.Oku, et al.
- Journal Title
  
  J. Controlled Release 100
  
  Pages: 41-52
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Polycation liposome enhances the endocytic uptake of photosensitizer into cells in the presence of serum.2003
- Author(s)
  Y.Takeuchi, N.Oku, et al.
- Journal Title
  
  Bioconjugate Chem. 74
  
  Pages: 790-796
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Induction of intensive tumor suppression by antiangiogenic photodynamic therapy using polycation-modified liposomal photosensitizer.2003
- Author(s)
  Y.Takeuchi, N.Oku, et al.
- Journal Title
  
  Cancer 97
  
  Pages: 2027-2034
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Journal Article] Application of polyethyleneglycol (PEG)-modified liposomes for oral vaccine ; effect of lipid dose on systemic and mucosal immunity.2003
- Author(s)
  S.Minato, N.Oku, et al.
- Journal Title
  
  J. Controlled Release 89
  
  Pages: 189-197
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15390050
[Patent] [18F]Fまたは蛍光色素で標識されたPEG化生物活性化合物の製造方法、ならびにその体内動態解析2014
- Inventor(s)
  赤井周司，奥　直人
- Industrial Property Rights Holder
  赤井周司，奥　直人
- Industrial Property Rights Type
  特許
- Filing Date
  2014-03-27
- Overseas
- Data Source
  KAKENHI-PROJECT-24659049
[Patent] [18F]Fまたは蛍光色素で標識されたPEG化生物活性化合物の製造方法、ならびにその体内動態解析2013
- Inventor(s)
  赤井周司，奥　直人
- Industrial Property Rights Holder
  静岡県立大学
- Industrial Property Rights Type
  特許
- Industrial Property Number
  2013-070277
- Filing Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659049
[Patent] Reverse Targeting Lipid Vesicles2009
- Inventor(s)
  Oku. N, etal.
- Industrial Property Rights Holder
  Oku. N, etal.
- Filing Date
  2009-02-18
- Overseas
- Data Source
  KAKENHI-PROJECT-20390014
[Patent] ポリカチオン化リン脂質誘導体2008
- Inventor(s)
  奥直人, 他
- Industrial Property Rights Holder
  奥直人, 他
- Filing Date
  2008-09-02
- Overseas
- Data Source
  KAKENHI-PROJECT-20015039
[Presentation] 凍結融解による簡便なタンパク質内封リポソームの調製とタンパク質の細胞内送達への応用2022
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  日本薬剤学会第37年会
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 血液中で標的分子を中和するポリマーリガンド修飾リポソームの開発2022
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第71回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 脂凍結融解技術を駆使した核酸・タンパク質送達方法の開発2022
- Author(s)
  小出裕之、米澤正、出羽毅久、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 温度に応答して標的分子を吸着・放出する多官能性ナノ粒子の開発とがん治療への応用2022
- Author(s)
  山口和馬、小出裕之、齊藤和弘、星野友、奥直人、浅井知浩
- Organizer
  遺伝子・デリバリー研究会第20回夏期セミナー
- Data Source
  KAKENHI-PROJECT-22K19384
[Presentation] 凍結融解技術を駆使した核酸・タンパク質送達方法の開発2022
- Author(s)
  小出裕之、米澤正、出羽毅久、奥直人、浅井知浩
- Organizer
  第38回日本DDS学会学術集会
- Invited
- Data Source
  KAKENHI-PROJECT-23K25211
[Presentation] 多官能性ポリマーナノ粒子の敗血症治療への応用2021
- Author(s)
  小出裕之、星野　友、奥　直人、シェアケネス、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of synthetic polymer nanoparticle for sepsis therapy2021
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Naoto Oku, Tomohiro Asai, Kenneth J,Shea
- Organizer
  Serendipity Symposium 2020
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 凍結融解技術を駆使したリポソームによるタンパク質の細胞内送達2021
- Author(s)
  平田真也、小出裕之、落合広樹、鈴木ひかる、出羽毅久、奥　直人、浅井知浩
- Organizer
  第67回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾リポソームの開発2021
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ynthetic polymer nanoparticles that release toxic peptides below lower critical solution temperature for cancer therapy2021
- Author(s)
  Hiroyuki Koide, Kazuhiro Saito, Keiichi Yoshimatsu, Yu Hoshino, Naoto Oku, Kenneth J. Shea, Tomohiro Asai
- Organizer
  Pacifichem
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子の開発とがん治療応用2021
- Author(s)
  安野　豪、小出裕之、齊藤和弘、星野　友、シアケネス、奥　直人、米澤　正、浅井知浩
- Organizer
  日本薬剤学会第36年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 標的分子を吸着し中和する多官能性リポソームの開発2021
- Author(s)
  鈴木ひかる、小出裕之、平野覚士、井出貴文、濱島義隆、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマー結合PEG修飾リポソームの開発2021
- Author(s)
  岡本卓巳、小出裕之、山内郁実、星野　友、奥　直人、浅井知浩
- Organizer
  第37回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of a synthetic polymer nanoparticle that captures and neutralizes target molecules in the body2021
- Author(s)
  Hiroyuki Koide, Hoshino Yu, Oku Naoto, Shea Kenneth, Asai Tomohiro
- Organizer
  第65回高分子討論会日韓ジョイントシンポジウム
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的分子を吸着・放出するナノゲル粒子を用いたがん治療研究2021
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第65回高分子討論会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答して標的ペプチドを吸着・放出する合成高分子ナノ粒子の開発とがん治療応用2021
- Author(s)
  小出裕之、齋藤和弘、星野友、Shea Kenneth、奥直人、浅井知浩
- Organizer
  第70回高分子討論会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 凍結融解技術を用いたタンパク質内封リポソームの調製と細胞内送達2021
- Author(s)
  落合広樹、小出裕之、鈴木ひかる、出羽毅久、奥直人、浅井知浩
- Organizer
  第36回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 標的分子を吸着してその機能を中和する合成高分子ナノ粒子「プラスチック抗体」開発2021
- Author(s)
  小出裕之、星野友、三浦佳子、シェアケネス、奥直人、浅井知浩
- Organizer
  日本薬剤学会第35年会
- Invited
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Development of polymer nanoparticles adsorbing α-glucosidase for diabetes treatment2019
- Author(s)
  Ayaka Masuda, Hiroyuki Koide, Hiromichi Egami,Yoshitaka Hamashima, Naoto Oku, Tomohiro asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 敗血症治療に向けた多官能性ポリマーナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、 Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Development of a plastic antibody that captures vascular endothelial growth factor (VEGF) for anticancer therapy2019
- Author(s)
  Hiroyuki Koide, Yu Hoshino, Yuri Noshimura, Yoshiko Miura, Naoto Oku, and Kenneth J Shea, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] Design of multi-functionalized liposome for adsorbing and neutralizing target molecules in vivo2019
- Author(s)
  Satoshi Hirano, Hiroyuki Koide, Takahumi Ide, Yoshitaka Hamashima, Naoto Oku, Tomohiro Asai
- Organizer
  ACS meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] ペプチドを可逆的に吸着・放出する温度応答性ナノゲル粒子の生体内応用2019
- Author(s)
  齋藤和弘、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第29回バイオ・高分子シンポジウム
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] タンパク質の細胞内送達を可能にする多官能性リポソームの開発2019
- Author(s)
  鈴木ひかる、小出裕之、菱木麻美、江上寛通、橋本博、濱島　義隆、出羽毅久、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 温度に応答してペプチドを吸着・放出するナノゲル粒子の生体内利用に向けた検討2019
- Author(s)
  齋藤和弘、小出裕之、星野友、Shea Kenneth J.、奥直人、浅井知浩
- Organizer
  第35回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 敗血症治療に向けた合成高分子ナノ粒子の開発2019
- Author(s)
  小出裕之、星野友、奥直人、浅井知浩
- Organizer
  第 65 回日本薬学会東海支部総会・大会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 生体内で標的毒素を中和するポリマー修飾リポソームの開発2019
- Author(s)
  山内郁実、小出裕之、星野友、奥直人、浅井知浩
- Organizer
  日本薬剤学会第34年会
- Data Source
  KAKENHI-PROJECT-19H04450
[Presentation] 脳虚血再灌流障害治療へ向けた HMGB-1 結合ポリマーナノ粒子の設計2018
- Author(s)
  沖嶋杏奈，小出裕之，清川千秋，星野友，三浦佳子，Kenneth J. SHEA，奥直人，浅井知浩
- Organizer
  日本薬学会東海支部合同学術大会2018
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 脳梗塞モデルラットを用いた血栓溶解療法におけるFasudil-Lipの脳保護効果の解析2018
- Author(s)
  山本裕和、柳田洋翼、奥　直人、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 脳梗塞モデルラットを用いた血栓溶解療法におけるFasudil-Lipの脳保護効果の解析2018
- Author(s)
  山本裕和、柳田洋翼、奥　直人、浅井知浩
- Organizer
  日本薬剤学会第33年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 脳虚血再灌流障害治療へ向けた HMGB-1 結合ポリマーナノ粒子の設計2018
- Author(s)
  沖嶋杏奈，小出裕之，清川千秋，星野友，三浦佳子，Kenneth J. SHEA，奥直人，浅井知浩
- Organizer
  日本薬学会東海支部合同学術大会2018
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Treatment of ischemic stroke by combination therapy with liposomal neuroprotectants plus tissue plasminogen activator2017
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 生体内で標的生体高分子を吸着するPEG修飾ポリマーナノ粒子の設計2017
- Author(s)
  林直希、小出裕之、有泉早紀、清川千秋、土田大貴、沖嶋杏奈、香門悠里、星野友、Kenneth J. Shea、奥直人
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] アクチベータブル蛍光プローブDDS製剤による動脈硬化宇安定プラークイメージング2017
- Author(s)
  成田雄大、清水広介、Maess Marten、間賀田泰寛、外村和也、小川美香子、奥　直人
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 脳梗塞を標的としたDDS製剤の開発2017
- Author(s)
  奥直人
- Organizer
  第2回生物構造学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] 動脈硬化不安定プラークの近赤外蛍光イメージングを目的としたマクロファージ標的化リポソームの開発2017
- Author(s)
  成田雄大、清水広介、間賀田泰寛、外村和也、小川美香子、奥　直人
- Organizer
  第12回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] Treatment of ischemic stroke by combination therapy with liposomal neuroprotectants plus tissue plasminogen activator2017
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku:
- Organizer
  The 12th China-Japan Symposium on Health Sciences
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Development of enzyme-specific, macrophage-targeted near-infrared fluorescence probe for easy diagnosis of atherosclerosis2017
- Author(s)
  Kosuke Shimizu, Yudai Narita, Marten Maess, Yasuhiro Magata, Mikako Ogawa, Naoto Oku
- Organizer
  Controlled Release Society 2017 Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 敗血症治療に向けたPEG含有ポリマーナノ粒子の開発2017
- Author(s)
  林直希、小出裕之、沖島杏奈、星野友、シェアケネスジェイ、奥直人
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Application of liposomal DDS for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku
- Organizer
  Annual Meeting of the German Pharmaceutical Society - DPhG
- Invited
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] マクロファージ標的化蛍光プローブによる動脈硬化不安定プラークの検出2017
- Author(s)
  清水広介、成田雄大、Marten Maess、外村和也、間賀田泰寛、奥　直人、小川美香子
- Organizer
  日本薬剤学会第32年会
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] Development of polymer nanoparticles with affinity to a vascular endothlial growth factor for cancer therapy2017
- Author(s)
  H. Koide, S. Ariizumi, Y. Hoshino, Y. Miura, S.J. Kenneth, N. Oku
- Organizer
  American Association of Pharmaceutical Scientists Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Application of liposomal DDS for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku
- Organizer
  Annual Meeting of the German Pharmaceutical Society（ DPhG）
- Invited
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Development of long-circulating polymer nanoparticles for sepsis treatment.2017
- Author(s)
  N. Hayashi, H. Koide, A. Okishima, Y. Kamon, Y. Hoshino, K.J. Shea, N. Oku
- Organizer
  American Association of Pharmaceutical Scientists Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] VEGFを吸着し中和する多官能性合成ポリマーナノ粒子を用いたがん治療2017
- Author(s)
  小出裕之、有泉早紀、沖嶋杏奈、星野友、三浦佳子、Kenneth J. Shea、奥直人
- Organizer
  第33回日本DDS学会学術集会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] リポソームDDS製剤と血栓融解剤併用による新規脳梗塞治療法の開発2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Organizer
  第26回DDSカンファランス
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Usefulness of liposomal neuro-protectants for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku, Tatsuya Fukuta, Hiroyuki Koide, Kosuke Shimizu, Tomohiro Asai
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] がん治療に向けたプラスチック人工抗体の開発2017
- Author(s)
  小出裕之、有泉早紀、星野友、三浦佳子、Kenneth J. Shea、奥直人：
- Organizer
  第81回日本生化学会中部支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Usefulness of liposomal neuro-protectants for the treatment of ischemic stroke2017
- Author(s)
  Naoto Oku, Tatsuya Fukuta, Hiroyuki Koide, Kosuke Shimizu, Tomohiro Asai
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Invited / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] リポソーム化脳保護薬と血栓溶解剤の併用による脳梗塞治療2017
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] NIRF imaging vulnerable atherosclerotic plaques with activatable probe-encapsulated liposomes2017
- Author(s)
  Yudai Narita, Kosuke Shimizu, Marten Maess, Kazuya Hokamura, Yasuhiro Magata, Mikako Ogawa, Naoto Oku
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] マクロファージ標的化アクチベータブル蛍光プローブによる動脈硬化不安定プラークの近赤外蛍光イメージング2017
- Author(s)
  清水広介、成田雄大、Marten Maess、外村和也、間賀田泰寛、奥　直人、小川美香子
- Organizer
  第12回日本分子イメージング学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] Combination therapy with liposomal fasudil and tissue plasminogen activator for ischemic stroke treatment2017
- Author(s)
  Yosuke Yanagida, Tatsuya Fukuta, Tomohiro Asai, Kosuke Shimizu, Hiroyuki Koide, Naoto Oku:
- Organizer
  Liposomes Advances Progress in Drug and Vaccine Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Combination therapy with liposomal fasudil and tissue plasminogen activator for ischemic stroke treatment2017
- Author(s)
  Yosuke Yanagida, Tatsuya Fukuta, Tomohiro Asai, Kosuke Shimizu, Hiroyuki Koide, Naoto Oku
- Organizer
  Liposome Advances Progress in Drug and Vaccine Delivery
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] VEGFと結合して中和する多官能性ポリマーナノ粒子の開発とがん治療へ応用2017
- Author(s)
  小出裕之、有泉早紀、星野友、三浦佳子、シェアケネス、奥直人
- Organizer
  第66回高分子討論会
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 脳梗塞を標的としたDDS製剤の開発2017
- Author(s)
  奥直人
- Organizer
  平成28年度第2回生物構造学研究会
- Invited
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] リポソームDDS製剤と血栓融解剤併用による新規脳梗塞治療法の開発2017
- Author(s)
  福田達也、浅井知浩、奥直人
- Organizer
  第26回DDSカンファランス
- Invited
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] リポソーム化脳保護薬と血栓溶解剤の併用による脳梗塞治療2017
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬学会第137年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] NIRF imaging of atherosclerotic plaques with fluorescence activatable probe and macrophage-targeting DDS2017
- Author(s)
  Yudai Narita, Kosuke Shimizu, Marten Maess, Kazuya Hokamura, Yasuhiro Magata, Mikako Ogawa, Naoto Oku
- Organizer
  AAPS Annual Meeting and Exposition
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 近赤外蛍光アクチベータブルプローブとマクロファージ標的化DDSによる動脈硬化不安定プラークイメージング2017
- Author(s)
  成田雄大、清水広介、間賀田泰寛、外村和也、小川美香子、奥　直人
- Organizer
  第81回日本生化学会中部支部例会・シンポジウム
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 脳保護薬内封リポソームと血栓溶解剤併用による脳梗塞治療2016
- Author(s)
  福田達也、柳田洋翼、浅井知浩、奥直人
- Organizer
  日本薬剤学会第31年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Multifunctional polymer-modified liposomes that capture and neutralize toxic protein, histones.2016
- Author(s)
  48.Hiroki Tsuchida, Hiroyuki Koide, Masahiko Nakamoto, Anna Okishima, Saki Ariizumi, Chiaki Kiyokawa, Tomohiro Asai, Yu Hoshino, Naoto Oku
- Organizer
  International Conference on Nanomedicine and Nanobiotechnoloty
- Place of Presentation
  Paris, France
- Year and Date
  2016-09-29
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Combination therapy with liposomal neuroprotective agents plus tissue plasminogen activator for the treatment of ischemic stroke.2016
- Author(s)
  Tatsuya Fukuta, Yosuke Yanagida, Tomohiro Asai, Naoto Oku
- Organizer
  2016 AAPS Annual Meeting and Exposition
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Liposome-Encapsulated Tacrolimus Ameliorates Total Brain Ischemia and Reperfusion Injury in the Rat.2016
- Author(s)
  Kawaguchi AT, Endo H, Yamano M, Fukuta T, Ishii T, Oku N.
- Organizer
  ASAIO 62th conference
- Place of Presentation
  Hyatt Regency San Francisco, Embarcadero Center (SAN FRANCISCO, CA, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 生体内で標的毒素を中和する“リポソーム解毒剤”の開発2016
- Author(s)
  43.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、星野友、奥直人
- Organizer
  第10回QCM研究会
- Place of Presentation
  東京
- Year and Date
  2016-08-26
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 生体内で標的毒素を中和する脂質ナノ粒子解毒剤“Nano-dotes”の開発2016
- Author(s)
  45.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、星野友、奥直人
- Organizer
  第25回DDSカンファランス
- Place of Presentation
  静岡
- Year and Date
  2016-09-02
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] Development of synthetic polymer nanoparticles interacting with HMGB1 for the treatment of cerebral ischemia/reperfusion injury2016
- Author(s)
  C. Kiyokawa, H. Koide, K.J. Shea, N. Oku
- Organizer
  2016 AAPS Annual Meeting and Exposition Final Program
- Place of Presentation
  Colorado Convention Center　(Denver, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 血管障害の診断・治療におけるDDS製剤の有用性2016
- Author(s)
  奥直人
- Organizer
  オレオナノサイエンス部会シンポジウム2016
- Invited
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Mitochondrial Complex-1活性のPET解析によるDDS製剤の脳保護効果評価2016
- Author(s)
  福田達也、浅井知浩、原田典弘、塚田秀夫、奥直人
- Organizer
  第16回放射性医薬品・画像診断薬研究会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] Combination therapy with liposomal neuroprotective agents plus tissue plasminogen activator for the treatment of ischemic stroke2016
- Author(s)
  T. Fukuta, Y. Yanagida, T. Asai, N. Oku
- Organizer
  2016 AAPS Annual Meeting and Exposition Final Program
- Place of Presentation
  Colorado Convention Center　(Denver, USA)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 生体内で標的毒素を中和するポリマーリガンド修飾脂質ナノ粒子の開発2016
- Author(s)
  59.土田大貴、小出裕之、仲本正彦、沖嶋杏奈、有泉早紀、清川千秋、浅井知浩、星野友、奥直人
- Organizer
  第38回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  名古屋
- Year and Date
  2016-11-17
- Data Source
  KAKENHI-PROJECT-16K15111
[Presentation] 脳虚血再灌流障害モデルにおけるリポソーム化Fasudilの脳内挙動解析と治療効果2016
- Author(s)
  柳田洋翼、福田達也、南場美緒、浅井知浩、奥直人
- Organizer
  日本薬剤学会第31年会
- Data Source
  KAKENHI-PROJECT-16H05081
[Presentation] miR-499血管正常化作用による抗がん剤の薬効増強2015
- Author(s)
  58.Sho Ryu, Hidenori Ando,劉暁、安藤英紀、前田典之、浅井知浩、出羽毅久、奥直人
- Organizer
  日本薬学会第135年会
- Place of Presentation
  神戸
- Year and Date
  2015-03-28
- Data Source
  KAKENHI-PROJECT-26670018
[Presentation] Miniature cardiopulmonary bypass for rats to undergo hypothermic circulatory arrest.2015
- Author(s)
  Kawaguchi AT, Kawaguchi G, Okubo T, Yokoi R, Sato K
- Organizer
  European Association for Artificial Organs
- Place of Presentation
  The Gasthuisberg hospital, Leuven, Belgium
- Year and Date
  2015-09-02
- Data Source
  KAKENHI-PROJECT-15H02569
[Presentation] 分子イメージングとDDS創薬2014
- Author(s)
  奥直人、清水広介、浅井知浩、菅敏幸、塚田秀夫
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-31
- Invited
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] リポソームを用いた脳虚血部位への脳保護剤デリバリー2014
- Author(s)
  11.福田達也、浅井知浩、佐藤晶彦、清水広介、南野哲男、塚田秀雄、奥直人
- Organizer
  第36回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  徳島
- Year and Date
  2014-11-21
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] NMDA受容体遮断薬内封リポソームを用いた脳虚血再灌流障害の治療2014
- Author(s)
  3.菊地隆司、上戸由里佳、福田達也、清水広介、浅井知浩、奥　直人
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] リポソームDDS製剤の虚血時投与による脳虚血/再灌流障害治療2014
- Author(s)
  1.福田達也、佐藤昌彦、菊地隆司、清水広介、浅井知浩、南野哲男、奥　直人
- Organizer
  日本薬剤学会第29年会
- Place of Presentation
  大宮
- Year and Date
  2014-05-20
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Development of anti-high mobility group box-1 synthetic polymer nanoparticles for the treatment of cerebral ischemia-reperfusion injury.2014
- Author(s)
  6.Tatsuya Fukuta, Hiroyuki Koide, Yu Hoshino, Yoshiko Miura, Kenneth J. Shea, Naoto Oku
- Organizer
  248th American Chemical Society National Meeting & Exposition
- Place of Presentation
  San Francisco, USA
- Year and Date
  2014-08-12
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳虚血時におけるリポソームの動態解析と脳梗塞治療への応用2014
- Author(s)
  2.福田達也、佐藤昌彦、菊地隆司、清水広介、浅井知浩、南野哲男、塚田秀夫、奥　直人
- Organizer
  第30回日本DDS学会学術集会
- Place of Presentation
  東京
- Year and Date
  2014-07-30
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] The design of a liposomal delivery system for the treatment of ischemic stroke.2014
- Author(s)
  5.Tomohiro Asai, Tatsuya Fukuta, Takayuki Ishii, Akihiko Sato, Takashi Kikuchi, Kosuke Shimizu, Hideo Tsukada, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Advanced cancer therapy by systemic administration of miR-499.2014
- Author(s)
  39.Sho Ryu, Hidenori Ando, Tomohiro Asai, Takehisa Dewa, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposome Research Days 2014
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2014-08-06
- Data Source
  KAKENHI-PROJECT-26670018
[Presentation] Delivery of neuroprotective agents to ischemic brain region using liposomes for stroke treatment.2014
- Author(s)
  10.Tatsuya Fukuta, Tomohiro Asai, Akihiko Sato, Kosuke Shimizu, Tetsuo Minamino, Hideo Tsukada, Naoto Oku
- Organizer
  The 2nd International Conference on Pharma and Food
- Place of Presentation
  静岡
- Year and Date
  2014-11-05
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Enhanced circulation of secondly injected PEGylated liposomes after injection of doxorubicin-encapsulatd PEGylated liposomes2013
- Author(s)
  Jantana Yahuafai, Yuri Kiyokawa, Yoshito Takeuchi, Daiki Saito, Kosuke Shimizu, Tomohiro Asai, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  The 5 th Conference
- Place of Presentation
  名古屋
- Year and Date
  2013-08-05
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] FK506封入PEG修飾リポソームによる脳虚血/再灌流障害治療2013
- Author(s)
  上戸由里佳、石井貴之、尾山大、安田和、福田達也、佐藤晶彦、清水広介、浅井知浩、南野哲男、奥直人
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳梗塞に対する新規脳保護療法の構築に向けたリポソームDDSの応用2013
- Author(s)
  佐藤晶彦、福田達也、石井貴之、尾山大、安田和、上戸由里佳、清水広介、浅井知浩、南野哲男、奥直人
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] ファージライブラリーを用いた長期血中滞留性ペプチドの探索2013
- Author(s)
  清河友理、中田貴志、古屋恵一、清水広介、浅井知浩、奥直人
- Organizer
  日本薬学会第133年会
- Place of Presentation
  横浜
- Year and Date
  2013-03-28
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Increased Half-life of secondly injected PEGylated liposomes in mice pretreated with doxorubicin-encapsulated PEGylated liposome2013
- Author(s)
  Jantana Yahuafai, Tomohiro Asai, Genki Nakamura, Yuri Kiyokawa, Yoshihito Takeuchi, Kosuke Shimizu, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  International Liposome Society 2013 Meeting Liposome Advances : Progress in Drug and Vaccine Delivery
- Place of Presentation
  London, UK
- Year and Date
  2013-12-14
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Identification of a novel peptide targeting to human tumor vasculature for drug delivery2012
- Author(s)
  Takashi Nakada, Koji Hirashima, Yuri Kiyokawa, Kentaro Hatanaka, Kosuke Shimizu, Tomohiro Asai, Nanoto Oku
- Organizer
  Liposome Research Days
- Place of Presentation
  Hangzou, China
- Year and Date
  2012-10-09
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] FK506封入PEG修飾リポソームを用いた脳虚血再灌流障害治療2012
- Author(s)
  石井貴之、上戸由里佳、尾山大、安田和、福田達也、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] リポソームDDS技術を応用した脳虚血/再灌流障害治療法の開発2012
- Author(s)
  石井貴之、浅井知浩、尾山大、福田達也、安田和、上戸由里佳、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームDDSを応用した脳虚血時における新規脳保護戦略の構築2012
- Author(s)
  福田達也、石井貴之、尾山大、安田和、上戸由里佳、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-30
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Development of PEGylated liposomes encapsulating FK506 for the treatment of cerebral ischemia/reperfusion injury2012
- Author(s)
  Takayuki Ishii, Tomohiro Asai, Dai Oyama, Yurika Agato, Nodoka Yasuda, Tatsuya Fukuta, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposome Research Days 2012
- Place of Presentation
  Hangzhou, China
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳梗塞に対する新規脳保護戦略構築に向けたリポソームDDSの応用2012
- Author(s)
  福田達也、石井貴之、尾山大、安田和、上戸由里佳、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第28回日本DDS学会学術集会
- Place of Presentation
  札幌
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Treatment of cerebral ischemia/reperfusion injury with asialoerythropoietin　-modified PEGylated liposomes2012
- Author(s)
  Tatsuya Fukuta, Takayuki Ishii, Tomohiro Asai, Dai Oyama, Nodoka Yasuda, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposome Research Days 2012
- Place of Presentation
  Hangzhou, China
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳虚血再灌流モデルラットにおけるFK506封入PEG修飾リポソームの薬理効果及び脳内挙動の解析2012
- Author(s)
  上戸由里佳、石井貴之、尾山大、安田和、福田達也、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  日本薬学会第132年会
- Place of Presentation
  札幌
- Year and Date
  2012-03-29
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] FK506のリポソーム化による脳虚血/再灌流障害抑制効果の増強2012
- Author(s)
  上戸由里佳、石井貴之、尾山大、安田和、福田達也、佐藤晶彦、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第58回日本薬学会東海支部総会･大会
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Identification of a novel peptide targeting to human tumor vasculature for drug delivery2012
- Author(s)
  T Nakada, K Hirashima, Y Kiyokawa, K Hatanaka, K Shimizu, T Asai, N Oku
- Organizer
  Liposome Research Days 2012
- Place of Presentation
  Hangzhou, China
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Treatment of Cerebral Ischemia-Reperfusion Injury with Liposomal Asialo-Erythropoietin2011
- Author(s)
  Dai Oyama, Takayuki Ishii, Tomohiro Asai, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposomes Jerusalem 2011
- Place of Presentation
  Jerusalem Israel
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Application of liposomal DDS for the treatment of ischemia/reperfusion injury2011
- Author(s)
  Naoto Oku, et al
- Organizer
  International Liposome Society 2011
- Place of Presentation
  London, UK(Invited)
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳虚血再灌流障害治療に向けたFK506封入PEG修飾リポソームの応用2011
- Author(s)
  安田和、石井貴之、尾山大、上戸由里佳、福田達也、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第33回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  岡山
- Year and Date
  2011-11-24
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Application of liposomal DDS for the treatment of ischemia/reperfusion injury2011
- Author(s)
  Naoto Oku, Takayuki Ishii, Dai Oyama, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino
- Organizer
  International Liposome Society 2011 Meeting
- Place of Presentation
  London, UK
- Year and Date
  2011-12-10
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] リポソームDDSによるAsialo-erythropoietinの脳虚血再灌流障害抑制効果の増強2011
- Author(s)
  石井貴之、浅井知浩、福田達也、尾山大、安田和、清水広介、南野哲男、奥直人
- Organizer
  第27回日本DDS学会
- Place of Presentation
  東京
- Year and Date
  2011-06-09
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Liposomal Drug Delivery System as a Potential Strategy for the Treatment of Cerebral Ischemia-Reperfusion Injury2011
- Author(s)
  Takayuki Ishii, Tomohiro Asai, Dai Oyama, Tatsuya Fukuta, Nodoka Yasuda, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  Liposomes Jerusalem 2011
- Place of Presentation
  Jerusalem Israel
- Year and Date
  2011-05-15
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] DDS製剤のイメージングと脳虚血再灌流障害治療の新戦略2010
- Author(s)
  奥直人
- Organizer
  第35回製剤セミナー
- Place of Presentation
  浜松
- Year and Date
  2010-07-21
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Treatment of cerebral ischemia-reperfusion injury by liposomal drug delivery system2010
- Author(s)
  Takayuki Ishii, Dai Oyama, Tomohiro Asai, Kosuke Shimizu, Tetsuo Minamino, Naoto Oku
- Organizer
  LRD/LLMB 2010 Conference
- Place of Presentation
  Vancouver, Canada
- Year and Date
  2010-08-04
- Data Source
  KAKENHI-PROJECT-22659010
[Presentation] Efficient cancer therapy by use of neo vascular-targeted liposomes2008
- Author(s)
  Oku, N.
- Organizer
  EHRLICH-2^<nd> World Conference on Magic Bullets
- Place of Presentation
  Numbers, Germany
- Year and Date
  2008-10-05
- Data Source
  KAKENHI-PROJECT-20390014
[Presentation] Liposomal application for cancer antineovascular therapy2008
- Author(s)
  Oku, N
- Organizer
  The 8^<th> Emerging Information and Technology Conference
- Place of Presentation
  Tainan, Taiwan
- Year and Date
  2008-07-27
- Data Source
  KAKENHI-PROJECT-20015039
[Presentation] Flow patterns of liposome-encapsulated hemoglobin (LEH) in cerebral ischemia as shown by ^〈18〉F-labeled LEH on PET in the rat.2008
- Author(s)
  Kawaguchi AT Haida M Oku N. Tsukada H, et al.
- Organizer
  American Society for Artificial Internal Organs ASAIO J 2008 ; 54:3A.
- Place of Presentation
  San Francisco
- Data Source
  KAKENHI-PROJECT-20249072
[Presentation] Flow patterns of liposome-encapsulated hemoglobin(LEH) in cerebral ischemia as shown by^<18> F-labeled LEH on PET in the rat2008
- Author(s)
  Kawaguchi AT, Haida M, Oku N, Tsukada H, et al
- Organizer
  ASAIO J
- Place of Presentation
  SF, CA
- Year and Date
  2008-06-20
- Data Source
  KAKENHI-PROJECT-20249072
[Presentation] 抗原特異的薬物送達技術、Reverse-Targeting DDS(RT-DDS)2007
- Author(s)
  奥直人
- Organizer
  第23回日本DDS学会
- Place of Presentation
  熊本
- Year and Date
  2007-06-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Presentation] Antigen-specific drug delivery, reverse-targeting DDS (RT-DDS)2007
- Author(s)
  N. Oku
- Organizer
  23rd Annual Meeting of The Japan Society of Drug Delivery System
- Place of Presentation
  Kumamoto
- Year and Date
  2007-06-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Presentation] Angiogenic vessel-targeted cancer therapy2006
- Author(s)
  Naoto Oku
- Organizer
  Particles 2006
- Place of Presentation
  Orlando,FL,USA
- Year and Date
  2006-05-14
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Presentation] Angiogenic vessel-targeted cancer therapy2006
- Author(s)
  N. Oku
- Organizer
  Particles
- Place of Presentation
  2006 Orlando FL,USA
- Year and Date
  2006-05-14
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-18390052
[Presentation] Neuroprotective Effect of PEGylated Liposomes Encapsulating FK506 on Cerebral Ischemia-reperfusion Injury.
- Author(s)
  Yurika Agato, Takayuki Ishii, Dai Oyama, Nodoka Yasuda, Tatsuya Fukuta, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino, Naoto Oku:
- Organizer
  40th Annual Meeting & Exposition of the Controlled Release Society
- Place of Presentation
  Honolulu, Hawaii, USA
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Increased Half-life of secondly injected PEGylated liposomes in mice pretreated with doxorubicin-encapsulated PEGylated liposomes
- Author(s)
  Jantana Yafuafai, Tomohiro Asai, Genki Nakamura, Yuri Kiyokawa, Yoshihito Takeuchi, Kosuke Shimizu, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  International Liposome Society 2013 Meeting
- Place of Presentation
  London UK
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] Enhanced circulation of secondly injected PEGylated liposomes after injection of doxorubicin-encapsulatd PEGylated liposomes
- Author(s)
  Jantana Yahuafai, Yuri Kiyokawa, Yoshito Takeuchi, Daiki Saito, Kosuke Shimizu, Tomohiro Asai, Pongpun Siripong, Kenji Hyodo, Hiroshi Ishihara, Hiroshi Kikuchi, Naoto Oku
- Organizer
  The 5th Asian Arden Conference
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-24659021
[Presentation] 脳虚血/再灌流障害治療を目的としたリポソームDDSの応用
- Author(s)
  石井貴之、尾山大、福田達也、安田和、上戸由里佳、佐藤晶彦、浅井知浩、清水広介、南野哲男、奥直人
- Organizer
  第22回DDSカンファランス
- Place of Presentation
  静岡
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Development of liposomal drug delivery system for ischemic stroke treatment before reperfusion of cerebral blood flow
- Author(s)
  Tatsuya Fukuta, Takayuki Ishii, Akihiko Sato, Yurika Agato, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino, Naoto Oku
- Organizer
  Development of liposomal drug delivery system for ischemic stroke treatment before reperfusion of cerebral blood flow
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Liposomal drug delivery system as a pre-reperfusion therapy for ischemic stroke
- Author(s)
  Fukuta T, Ishii T, Sato A, Agato Y, Shimizu K, Asai T, Minamino T, Tsukada H, Oku N
- Organizer
  The 4th International Symposium on Artificial Oxygen Carriers
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] Liposomal drug delivery system for the treatment of ischemic stroke before restoration of cerebral blood flow
- Author(s)
  Tatsuya Fukuta, Tomohiro Asai, Akihiko Sato, Yurika Agato, Kosuke Shimizu, Hideo Tsukada, Naoto Oku
- Organizer
  International Liposome Society 2013 Meeting
- Place of Presentation
  London, UK
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] 脳梗塞新規治療戦略構築に向けたリポソームDDSの応用
- Author(s)
  福田達也、佐藤晶彦、清水広介、浅井知浩、南野哲男、塚田秀夫、奥直人
- Organizer
  日本薬剤学会第28年会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-23249005
[Presentation] NMDA受容体遮断薬内封リポソームを用いた脳虚血/再灌流障害治療による神経保護
- Author(s)
  上戸由里佳、石井貴之、菊地隆司、福田達也、清水広介、浅井知浩、奥直人
- Organizer
  第35回生体膜と薬物の相互作用シンポジウム
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-23249005

1. ASAI Tomohiro (00381731)

# of Collaborated Projects: 11 results

# of Collaborated Products: 80 results
2. SHIMIZU Kosuke (30423841)

# of Collaborated Projects: 9 results

# of Collaborated Products: 50 results
3. Koide Hiroyuki (60729177)

# of Collaborated Projects: 5 results

# of Collaborated Products: 46 results
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35. HIRASHIMA Naohide (10192296)

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36. OHWADA Tomohiko (20177025)

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37. UNNO Keiko (10106437)

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38. ARAKI YOSHIHIKO (70250933)

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55. HASEGAWA So

# of Collaborated Projects: 1 results

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# of Collaborated Projects: 1 results

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OKU Naoto 奥 直人

奥 直人 オク ナオト

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Development of liposomal plastic antibody for novelDDS and applicaion for sepsis treatmentPrincipal Investigator

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Development of FA-Snap, a smart DDS drug, for proposing an innovative therapeutic modality of ischemic stroke.Principal Investigator

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Novel strategy of tumor treatiment via the normalization of tumor vasculature by microRNAPrincipal Investigator

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Innovation of a novel technology for supporting the development of DDS drugs and protein medicines by controling their pharmacokinetics.Principal Investigator

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New development of diagnostic and therapeutic modality for ischemia/reperfusion injury by intelligent DDSPrincipal Investigator

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OKU Naoto 奥直人

奥直人オクナオト