IMAI Kiyohiro 今井清博

Researcher Number	50028528
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2015: 法政大学, 生命科学部, 教授 2012: 法政大学, 生命機能学部, 教授 2008 – 2012: Hosei University, 生命科学部, 教授 2011: 法政大学, 工学部, 教授 2007: Hosei University, 工学部, 教授 … More 2002 – 2004: 法政大学, 工学部, 教授 2001: 大阪大学, 医学系研究科, 助教授 1987 – 1996: Associate professor, Osaka Univ. Medical School, 医学部, 助教授 1986: 大阪大学, 医学部, 講師 1986: 阪大, 医学部, 講師 Less
Review Section/Research Field	Principal Investigator General physiology / Biophysics / Evolutionary biology Except Principal Investigator General physiology / Emergency medicine / 生物物性学 / General medical chemistry
Keywords	Principal Investigator ヘモグロビン / Hemoglobin / 分子進化 / 部位特異的変異導入 / 人工変異体 / 蛋白質工学 / 酸素親和性 / アミノ酸置換 / アロステリック効果 / ミオグロビン … More / Site-directed mutagenesis / Artificial mutants / 人工変異蛋白質 / 円口類 / 祖先型蛋白質 / amino acid sequence / molecular evolution / Fourier-transform infrared absorption / electron paramagnetic resonance spectrum / oxygen binging characteristics / myoglobin / hemoglobin / lamprey / 酸素平衡特性 / 一次構造 / フーリエ変換近赤外線吸収 / アミノ酸配列 / フーリエ変換赤外線吸収 / 電子常磁性共鳴スペクトル / 酸素結合特性 / ヤツメウナギ / Molecular dynamics / Molecular evolution / Molecular spectroscopy / Artificial mutation / Myoglobin / Oxygen binding proteins / 分子動力学 / 分子分光学 / 人工変異 / 酸素結合蛋白質 / Species adaptation / Protein engneering / Ligand affinity / Oxygen affinity / 種の適応 / リガンド親和性 / Bovine hemoglobin / Crocodile hemoglobin / Function mimicry / Functional differentiation / Protein engineering / 炭酸水素イオン / ワニ / 生理機能の分化 / ウシ・ヘモグロビン / ワニ・ヘモグロビン / 機能の模擬 / 機能分化 / Allosteric Effect / Recombinant DNA / Amino Acid Substitution / Protein Engineering / Site-directed Mutagenesis / Artificial Mutants / 部位指定変異導入 / ヘモグトビン / 組換えDNA / タンパク質工学 / 大腸菌 / 部位指定変異導入法 / 機能改変 / アロステリック単位 / 協同効果 / 酸素平衡曲線 / 酸素結合 / 巨大分子酸素担体 / 魚類 / 硬骨魚類 / 進化系統樹 / 逆分子進化 / 遺伝子組換え / 祖先型 / 分子設計 / ヘム蛋白質 … More Except Principal Investigator ヘモグロビン / Hemoglobin / ボーア効果 / 酸素結合機能 / SH3 / 赤血球 / 老化 / Comparative physiology / Xenopus laevis / Salamander / Amphibia / Bohr effect / Oxygen binding function / 協同効果 / 酸素平衡曲線 / 酸素親和性 / 比較生理学 / アフリカツメガエル / サンショウウオ / 両棲類 / Intermediate / Two state model / Bohr Effect / Conformation / Metalloporphyrin / Allosteric / 立体構造エネルギー / ラマン分光 / ボーアグループ / 混成ヘモグロビン / アロステリック / 2状態モデル / 構造 / 遺伝子操作 / 中間状態 / 金属ポルフィリン / アロステリック効果 / quaternary structure transition / tryptophan / tyrosine / mutants / UV resonance Raman / near-UV CD / hemoglobin / 円二色性 / 共鳴ラマン分光 / SrcSH3 domein / 異常血色素 / PI3K / 円二色性(CD) / 蛋白質の機能 / アロステリックエフェクター / HbM / 共鳴ラマン / CD / 芳香族アミノ酸 / 高次構造変化 / 四次構造変化 / トリプトファン / チロシン / 変異体 / 紫外共鳴ラマン / 近紫外域CD / Rheology / Deformability, / Energy metabolism, / ATP, / 2.3-DPG, / Aging, / Life span, / Erythrocytes, / レオロジ- / 変形能 / エネルギ-代謝 / ATP / 2,3ーDPG / 寿命 / 立体構造形成要因の解析 / ヘモグロビン変異体 / チトクロムP-450 / 変異蛋白質のデザインによる機能解析 / 二次および三次構造予知 / 膜蛋白質 / モジュール構造 / 蛋白質分子の立体構造形成と機能発現 / 再還流障害 / 人工酸素運搬対 / 水素 / シアン中毒 / 一酸化炭素中毒 / 酸素代謝障害 / 再灌流障害 / 虚血 / 人工酸素運搬体 / 薬理学 / 内呼吸 / 外呼吸 / 酸素 / エネルギー代謝 / 救急 / 救命 / ナノバイオ / 酸素ラジカル / 酸化ストレス / 虚血・再還流 / 創傷治癒 / 脳梗塞 / 微小循環 / 人工赤血球 / 救急蘇生学 Less

Innovative Approaches for Oxygen Metabolism Disorder with Artificial Oxygen Carriers and Related Compounds
- Principal Investigator
  
  KAWAGUCHI Akira
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Clarification of hemoglobin evolution process by reverse molecular evolutionPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Evolutionary biology
- Research Institution
  Hosei University
Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements
- Principal Investigator
  
  KAWAGUCHI Akira
- Project Period (FY)
  2008 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Emergency medicine
- Research Institution
  Tokai University
Experimental verification of acquisition of hemoprotein high-order functions by reverse molecular evolutionPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  2007 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Evolutionary biology
- Research Institution
  Hosei University
Relation between the structure and function of proteins studied by the changes of tyrosine and tryptophan residues.
- Principal Investigator
  
  NAGAI Masako
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  Hosei University
  Kanazawa University
Structure, function and evolution of cyclostomata hemoglobin and myoglobinPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Biophysics
- Research Institution
  Hosei University
  Osaka University
Molecular manipulation of oxygen binding proteins and new development of precise structure-function studies on themPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Biophysics
- Research Institution
  Osaka University
Study of the regulation mechanism of ligand affinity of hemoglobin by protein engineeringPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka University
Study on the differentiation of physiological function of hemoglobin using artificial mutantsPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka University
Mechanism of impaired rheology of aged erythrocytes in relation to the determinants of life span
- Principal Investigator
  
  SHIGA Takeshi
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Osaka University
Studies on the Mechanism of Physiological Function of Hemoglobin by Using Artificial MutantsPrincipal Investigator
- Principal Investigator
  
  IMAI Kiyohiro
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  General physiology
- Research Institution
  Osaka University
蛋白質工学によるヘモグロビン分子機能の改変Principal Investigator
- Principal Investigator
  
  今井清博
- Project Period (FY)
  1987
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Osaka University
巨大分子酸素担体の分子構築と機能発現の機序Principal Investigator
- Principal Investigator
  
  今井清博
- Project Period (FY)
  1986
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Osaka University
蛋白質分子の立体構造形成と機能発現メカニズムに関する研究
- Principal Investigator
  
  旗野昌弘
- Project Period (FY)
  1986 – 1988
- Research Category
  
  Grant-in-Aid for Special Project Research
- Research Institution
  Tohoku University
Comparative physiological studies of regulation mechanism of hemoglobin function
- Principal Investigator
  
  TYUMA Itiro
- Project Period (FY)
  1986 – 1987
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  General physiology
- Research Institution
  Osaka University Medical School
The allosteric effect in hemoglobin.
- Principal Investigator
  
  MORIMOT H.
- Project Period (FY)
  1985 – 1987
- Research Category
  
  Grant-in-Aid for Co-operative Research (A)
- Research Field
  
  生物物性学
- Research Institution
  Faculty of Engineering Science Osaka University

All 2014 2013 2012 2011 2010 2009 2008 2007

All Journal Article Presentation Book

[Book] Fronteras Cientificas en el Siglo XXI (Javier Navarro, Ed., Kosmotropic salts from the Hofmeister series decrease the oxygen affinity of human hemoglobin A)2007
- Author(s)
  A. Tsuneshige, K. Imai, T. Haga
- Publisher
  Editorial Cordillera SAC
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Circular dichroism of hemoglobin and myoglobin2014
- Author(s)
  Masako Nagai M., Yoshifumi Nagai Y., Kiyohiro Imai K., and Saburo Neya S.
- Journal Title
  
  Chrality
  
  Volume: 15 Issue: 9 Pages: 438-442
- DOI
  10.1002/chir.22273
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24249086
[Journal Article] Electronic Control of Discrimination between O2 and CO in Myoglobin Lacking the Distal Histidine Residue2013
- Author(s)
  R. Nishimura, T. Shibata, I. Ishigami, T. Ogura, H. Tai, S. Nagao, T. Matsuo, S Hirota, O. Shoji, Y. Watanabe, K. Imai, S. Neya, A. Suzuki, Y. Yamamoto
- Journal Title
  
  Inorg. Chem.
  
  Volume: 53 Issue: 2 Pages: 1091-1099
- DOI
  10.1021/ic402625s
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-24225004, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24550189, KAKENHI-PUBLICLY-25105724, KAKENHI-PUBLICLY-25109540
[Journal Article] Relationship between the Electron Density of the Heme Fe Atom and the Vibrational Frequencies of the Fe-Bound Carbon Monoxide in Myoglobin2013
- Author(s)
  R. Nishimura, T. Shibata, H. Tai, I. Ishigami, T. Ogura, S. Nagao, T. Matsuo, S. Hirota, K. Imai, S. Neya, A. Suzuki, and Y, Yamamoto
- Journal Title
  
  Inorg. Chem.
  
  Volume: 52 Issue: 6 Pages: 3349-3355
- DOI
  10.1021/ic3028447
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11J00949, KAKENHI-PROJECT-23655151, KAKENHI-PROJECT-24249086, KAKENHI-PROJECT-24350086, KAKENHI-PROJECT-24550189, KAKENHI-PUBLICLY-23105530, KAKENHI-PUBLICLY-23108703
[Journal Article] Relationship between oxygen affinity and autoxodation of myoglobin.2012
- Author(s)
  Shibata, T, Matsumoto, D;, Nishimura, R, Tai, H, Matsuoka, A, Nagao, S, Matsuo, T, Hirata, S, Imai, K, Neya, S, Suzuki, A. and Yamamoto, T.
- Journal Title
  
  Inorg. Chem
  
  Volume: 51 Pages: 11955-11960
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Near-UVcircular dichroism and UV resonance Ramanspectra of individual tryptophan residues inhuman hemoglobin and their changes uponthe quaternary st2012
- Author(s)
  Nagai, M, Nagatomo, S, Nagai, Y, Ohkubo,K, Imai, K, and Kitagawa, T.
- Journal Title
  
  Biochemistry
  
  Volume: 51 Pages: 5932-5941
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Determination of oxygen binding properties of the individual subunits of intact human adult hemoglobin2011
- Author(s)
  A. Sato, H. Tai, S. Nagatomo, K. Imai and Y.Yamamoto
- Journal Title
  
  Bull. Chem. Soc. Jpn
  
  Volume: 84 Pages: 1107-1111
- NAID
  10030215259
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Allosteric models of hemoglobin, still evolving, In Hemoglobin: Recent Developments and Topics2011
- Author(s)
  H. Fujimoto and K. Imai
- Journal Title
  
  Research Signpost, Kerala, India (M. Nagai, ed.)
  
  Pages: 161-177
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Differences in coordination states of substituted tyrosine residues and quaternary structures among hemoglobin M probed by resonance Raman spectroscopy2010
- Author(s)
  Y. Aki, M. Nagai, Y. Nagai, K. Imai, M. Aki, A. Sato, M. Kubo, S. Nagatomo and T. Kitagawa
- Journal Title
  
  J. Biol. Inorg. Chem.
  
  Volume: Vol. 15 Pages: 147-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Diffrerences in coordination states of substituted tyrosine residues and quaternary structures among hemoglobin M probed by resonacne Raman spectroscopy2010
- Author(s)
  Y. Aki, M. Nagai, Y. Nagai, K. Imai, M. Aki, A. Sato, M. Kubo, S. Nagatomo, T. Kitagawa
- Journal Title
  
  J. Biol. Inorg. Chem. 15
  
  Pages: 147-158
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Effect of heme modification on oxygen affinity of myoglobin and equilibrium of the acid-alkaline transition in metmyoglobin2010
- Author(s)
  T. Shibata, S. Nagao, M. Fukaya, H. Tai, S.Nagatomo, K. Morihashi, T. Matsuo, S. Hirota, A. Suzuki, K. Imai and Y. Yamamoto
- Journal Title
  
  J. Am. Chem. Soc.
  
  Volume: Vol. 132 Pages: 6091-6098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Molecular insight into intrinsic heme distortion in ligand binding in hemoprotein2010
- Author(s)
  S. Neya, M. Suzuki, T. Hoshino, H. Ode, K. Imai, T. Komatsu, A. Ikezaki, M. Nakamura,Y. Furutani and H. Kandon
- Journal Title
  
  Biochemistry.
  
  Volume: Vol. 49 Pages: 5642-5650
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22570217
[Journal Article] Analysis of the water binding capacity of membrane by molecular dynamics simulation.2009
- Author(s)
  Yamaguchi J, Imai Y, Mori K, Suzuyki M, Neya S, Hoshino T.
- Journal Title
  
  e-J Surface Sci Nanotech 28
  
  Pages: 170-176
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249072
[Journal Article] Functional evaluation of iron oxypyriporphyrin in protein heme pocket2008
- Author(s)
  S. Neya, M. Suzuki, H. Ode, T. Hashimoto, Y. Furutani, H. Kandori, H. Hori, K. Imai, T. Komatsu
- Journal Title
  
  Inorg. Chem. 47
  
  Pages: 10771-10778
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Effect of reversed heme orientation on circular dichroism and cooperative oxygen binding of human adult hemoglobin2008
- Author(s)
  M. Nagai, Y. Nagai, Y. Aki, K. Imai, Y. Wada, S. Nagatomo, Y. Yamamoto
- Journal Title
  
  Biochemistry 47
  
  Pages: 517-525
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Reduction in hemoglobin-oxygen affinity results in the improvement of exercise capacity in mice with chronic heart failure2008
- Author(s)
  T. Watanabe, T. Takeda, S. Omiya, S. Hikoso, O. Yamaguchi, Y. Nakano, Y. Higuchi, A. Nakai, Y. Abe, Y. Aki-Jin, M. Taniike, I. Mizote, Y. Matsumura, T. Shimizu, K. Nishida, K. Imai, M. Hori, T. Shirasawa, K. Otsu
- Journal Title
  
  J. Amer. College Cardiol. 52
  
  Pages: 779-786
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Changes of near-UV CD spectra of human hemoglobin upon the R→T quaternary structure transition2007
- Author(s)
  Y. Aki-Jin, Y. Nagai, K. Imai, M. Nagai
- Journal Title
  
  ACS Symposium Series on New Approaches in Biomedical Spectroscopy 963
  
  Pages: 297-311
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] 哺乳類ヘモグロビンの協同作用とボーア効果は協調して酸素の獲得と輸送を行っている-規範タンパク質における新たな視点-2007
- Author(s)
  張岩、今井清博、小林道頼
- Journal Title
  
  生物物理 47
  
  Pages: 167-173
- NAID
  110006273084
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Oxygenation properties of extracellular giant hemoglobin from Oligobrachia mashikoi2007
- Author(s)
  Y. Aki, T. Nakagawa, M. Nagai, Y. Sasayama, Y. Fukumori, K. Imai
- Journal Title
  
  Biochim. Biophys. Res. Commun 360
  
  Pages: 673-678
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Journal Article] Heme orientational disorder in human adult hemoglobin reconstituted with a ring Fluorinated heme and its functional consequences2007
- Author(s)
  S. Nagao, Y. Hirai, S. Kawano, K. Imai, A. Suzuki, Y. Yamamoto
- Journal Title
  
  Biochem. Biophys. Res. Commun 354(3)
  
  Pages: 681-685
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 硬骨魚類の祖先型ヘモグロビン Node296α・Node203β 遺伝子設計・合成および大腸菌内発現2012
- Author(s)
  杉山将,松尾高稔,関一葉,中川太郎,今井清博
- Organizer
  マイクロ・ナノテクノロジー研究センター開設 10 周年記念シンポジウム
- Place of Presentation
  法政大学,東京都
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ヒトヘモグロビンの酸素結合機能における近位ヒスチジンの役割2012
- Author(s)
  丸山夏未,安芸弥生,長井幸史,今井清博,長友重紀,小倉尚志,北川禎三,長井雅子
- Organizer
  第85回日本生化学会大会(2P-357
- Place of Presentation
  福岡国際会議場,マリンメッセ福岡,福岡県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ヘモグロビンの自動酸化速度に対する糖類の効果2012
- Author(s)
  上原航,今井清博
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学,愛知県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] トリプトファンの近紫外円二色性及び紫外共鳴ラマンに基づくヘモグロビンの四次構造変化の解明2012
- Author(s)
  長井雅子,長友重紀,長井幸史,大久保賢一, 今井清博,北川禎三
- Organizer
  第39回生体分子科学討論会要旨集
- Place of Presentation
  東北大学,宮城県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ヒトヘモグロビンのβ145Tyr の Thr または Leu への置換が機能と構造に与える影響2012
- Author(s)
  一居桃子,長井幸史,今井清博,長井雅子
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学,愛知県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ヤツメウナギ由来の祖先型ヘモグロビン遺伝子(node25)の発現系構築2012
- Author(s)
  幕晋一,松尾高稔,中川太郎,今井清博
- Organizer
  マイクロ・ナノテクノロジー研究センター開設10周年記念シンポジウム
- Place of Presentation
  法政大学,東京都
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] 硬骨魚類の祖先型ヘモグロビン遺伝子の設計・合成およびその大腸菌内発現2012
- Author(s)
  杉山将, 松尾高稔, 関一葉, 長井幸史, 中川太郎,今井清博
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学愛知県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] Expression of ancestral Cyclstomes hemoglobin Node23 gene in Escherichia coli2012
- Author(s)
  松尾高稔,喜多かつら,尾澤雄太,中川太郎,今井清博
- Organizer
  マイクロ・ナノテクノロジー研究センター開設10周年記念シンポジウム
- Place of Presentation
  法政大学東京都
- Year and Date
  2012-10-13
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ヒトヘモグロビンのα鎖の近位ヒスチジンのグリシンへの置換が構造と酸素結合機能に与える影響2012
- Author(s)
  安芸弥生,長井幸史,今井清博,長友重紀,小倉尚志,北川禎三,長井雅子
- Organizer
  第50回日本生物物理学会年会
- Place of Presentation
  名古屋大学,愛知県
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] ミオグロビンの機能調節機構の解明2011
- Author(s)
  西村龍、松本大地、西山康太郎、柴田友和、深谷昌史、太虎林、長尾聡、松尾貴史、廣田俊、鈴木秋弘、今井清博、石上泉、小倉尚志、根矢三郎、庄司長三、渡辺芳人、山本泰彦
- Organizer
  第38回生体分子科学討論会
- Place of Presentation
  筑波大学,茨城県
- Year and Date
  2011-06-23
- Data Source
  KAKENHI-PROJECT-22570217
[Presentation] Hemoglobin as the normative protein2009
- Author(s)
  K. Imai
- Organizer
  第47回日本生物物理学会年会「Symposium "Hemoglobin revisted"」
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Structure and function of Root effect fish hemoglobins2009
- Author(s)
  S. Unzai, K. Imai, T. Yokoyama, S. Park, K. Nagai, J. Tame
- Organizer
  第47回日本生物物理学会年会「シンポジウム"ヘモグロビンはいま"」
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Relationship between oxygen affinity of myoglobin and the equililbrium constant of acid- alkaline transition in metmyoglobin2009
- Author(s)
  T. Shibata, K. Mizuseki, S. Nagao, H. Tai, S. Nagatomo, A. Suzuki, K. Imai, Y. Yamamoto
- Organizer
  14th International Conference on Biological Inorganic Chemistry
- Place of Presentation
  Nagoya
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Tetramer-dimer equilibrium of chemically modified hemoglobin as studied by protein concentration- dependences of the oxygen equilibrium curve2009
- Author(s)
  T. Inao, S. Kuriyama, K. Imai
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Hemoglobin as the normative protein2009
- Author(s)
  K.Imai
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  徳島文理大学
- Year and Date
  2009-11-01
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] ヘム側鎖の修飾がミオグロビンの酸素親和性と酸塩基平衡に与える影響2009
- Author(s)
  柴田友和、水関和哉、長尾聡、太虎林、長友重紀、鈴木秋弘、今井清博、山本泰彦
- Organizer
  日本化学会第89回春期年会
- Place of Presentation
  日大工学部(船橋市)
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Coordiation states of proximal or distal tyrosine residue in hemoglobins M and their quaternary structures probed by resonance Raman spectroscopy2009
- Author(s)
  Y. Aki, M. Nagai, K. Imai, M. Aki, T. Kitagawa
- Organizer
  第47回日本生物物理学会年会
- Place of Presentation
  徳島
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 規範蛋白質としてのヘモグロビン2008
- Author(s)
  今井清博
- Organizer
  兵庫県立大学大学院生命理学研究科グローバルCOEプログラム「ピコバイオロジー : 原子レベルの生命科学」グローバルCOE研究集会
- Place of Presentation
  兵庫県立先端科学支援センター
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Circular Dichroism and Oxygen Binding Properties of Human Adult Hemoglobin with Reversed Heme2008
- Author(s)
  M. Nagai, Y. Nagai, Y. Aki, K. Imai, S. Nagatomo, Y. Yamamoto
- Organizer
  Biophysical Society 52nd Annual Meeting and 16th International Biophysics Congress (IUPAB)
- Place of Presentation
  Long Beach, California, USA
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Temperature- dependences of oxygen binding by myoglobin from animals with different body temperatures2008
- Author(s)
  M. Ishida, M. Hashiride, I. Yamasaki, A. Yasuda, Y. Murakami, M. Ota, Y. Isogai, K. Imai
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Functional properties of mersaryl-modified hemoglobin (2)2008
- Author(s)
  S. Kuriyama, Y. Aki, K. Imai
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Circular dichroism of the extracellular giant hemoglobin from annelied, Oligobrachia mashikoi2008
- Author(s)
  T. Nakagawa, Y. Fukumori, K. Imai, M. Nagai
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Temperature-dependence of auto- oxidation of ancestral and closely related extant myoglobins (2)2008
- Author(s)
  M. Ishida, Y. Murakami, A. Yasuda, I. Yamasaki, M. Ota, Y. Isogai, K. Imai
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Environmental alteration of three tryptophan residues in human adult hemoglobin upon ligand binding2008
- Author(s)
  M. Nagai, Y. Nagai, Y. Aki, K. Imai, S. Nagatomo, T. Kitagawa
- Organizer
  Proceedings of the XX1st International Conference on Raman Spectroscopy
- Place of Presentation
  London
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 逆配向ヘムをもつヘモグロビンの酸素平衡機能と円二色性2008
- Author(s)
  長井雅子、長井幸史、今井清博、安芸弥生、長友重紀、山本泰彦
- Organizer
  第35回生体分子科学討論会講演要旨集
- Place of Presentation
  兵庫県立先端科学支援センター
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] Environmental alteration of three tryptophan residues in human adult hemoglobin (Hb A): A near-UV circular dichroism study2008
- Author(s)
  K. Ohkubo, Y. Aki, K. Imai, Y. Nagai, M. Nagai
- Organizer
  第46回生物物理学会年会
- Place of Presentation
  博多
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 規範蛋白質としてのヘモグロビン2008
- Author(s)
  今井清博
- Organizer
  兵庫県立大学大学院生命理学研究科グローバルCOEプログラム「ピコバイオロジー:原子レベルの生命科学」グローバルCOE研究集会:ヘモグロビン-この未知なるもの-
- Place of Presentation
  兵庫県立先端科学技術支援センター
- Year and Date
  2008-11-21
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 祖先型と最近接現存種ミオグロビンの自動酸化反応の温度依存性2007
- Author(s)
  石田学、村上祐太、安田温、山崎伊織、太田元規、磯貝泰弘、今井清博
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 酸素結合特性に対するpH及び温度の効果2007
- Author(s)
  石田学、山崎伊織、村上祐太、太田元規、磯貝泰弘、今井清博:組み換え祖先型ミオグロビン
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] ヒトヘモグロビンにおける3つのトリプトファン残基の酸素結合にともなう変化:近紫外CDおよび紫外共鳴ラマン分光による研究2007
- Author(s)
  長井雅子、長井幸史、小久保昭秀、川口裕貴、安藝弥生、今井清博、長友重紀、北川禎三
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 有髭動物マシコヒゲムシのもつ巨大ヘモグロビンの酸素運搬機能2007
- Author(s)
  安藝弥生、中川太郎、長井雅子、笹山雄一、福森義宏、今井清博
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570222
[Presentation] 化学修飾ヘモグロビンの機能特性2007
- Author(s)
  栗山紗子、安藝弥生、今井清博
- Organizer
  第45回日本生物物理学会年会
- Place of Presentation
  横浜
- Data Source
  KAKENHI-PROJECT-19570222

1. NAGAI Masako (60019578)

# of Collaborated Projects: 4 results

# of Collaborated Products: 20 results
2. MIYAZAKI Gentaro (50166146)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
3. WATANABE Manabu (30182950)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. KITAGAWA Teizo (40029955)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MORIMOTO Hideki (20029474)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. TSUNESHIGE Antonio (30409346)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
7. KAWAGUCHI Akira (30195052)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. KANO Koji (60038031)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
9. NEYA Saburo (10156169)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
10. YAMANO Mariko (80192409)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
11. OKU Naoto (10167322)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. SHIRAI Mikiyasu (70162758)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
13. INOKUCHI Sadaki (60160008)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
14. HAIDA Munetaka (20208408)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
15. KURODA Yasuhiro (40398756)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. MATSUO Takatoshi (00500737)

# of Collaborated Projects: 1 results

# of Collaborated Products: 7 results
17. NAKAGAWA Taro (30401889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
18. MURAYAMA Chieko (50307295)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. TAMAKI Tetsuro (10217177)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. ENDO Hitoshi (10550551)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. SHIGA Takeshi (10028350)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. MAEDA Nobuji (50036464)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. ISHIMORI Koichiro (20192487)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. KOSAKA Hiroaki (60158897)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. IIZUKA Tetsutaro (30029475)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MORISHIMA Isao (50026093)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. HORI Hiroshi (20127294)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. YAZAWA Yoichi (30000871)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. OKOUCHI Shoichi (90105859)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. SAKURAI Hiroshi (00225848)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. GO N. (50011549)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. KAJITA A. (80049113)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. TYUMA Itiro (10028269)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
34. YOKOTA Shizuo (00191502)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
35. 旗野昌弘 (50006293)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
36. 油谷克英 (90089889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
37. 齋藤信彦 (20063125)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
38. 和田昭允 (10011462)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
39. 須貝新太郎 (80000727)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
40. 小西康子 (80129238)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
41. KAWAMURA-KONISHI Y.

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
42. SHOJI Osami

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
43. 渡辺芳人

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

IMAI Kiyohiro 今井 清博

Research Projects

Research Products

Co-Researchers

Innovative Approaches for Oxygen Metabolism Disorder with Artificial Oxygen Carriers and Related Compounds

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Clarification of hemoglobin evolution process by reverse molecular evolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Utility of Innovative Artificial Oxygen Carriers for Diseases Derived From Circulatory Derangements

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Experimental verification of acquisition of hemoprotein high-order functions by reverse molecular evolutionPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Relation between the structure and function of proteins studied by the changes of tyrosine and tryptophan residues.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Structure, function and evolution of cyclostomata hemoglobin and myoglobinPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular manipulation of oxygen binding proteins and new development of precise structure-function studies on themPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of the regulation mechanism of ligand affinity of hemoglobin by protein engineeringPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the differentiation of physiological function of hemoglobin using artificial mutantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Mechanism of impaired rheology of aged erythrocytes in relation to the determinants of life span

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Studies on the Mechanism of Physiological Function of Hemoglobin by Using Artificial MutantsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

蛋白質工学によるヘモグロビン分子機能の改変Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

巨大分子酸素担体の分子構築と機能発現の機序Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Institution

IMAI Kiyohiro 今井清博