Kuwahara Kyoko 桑原京子

… Alternative Names

KUWAHARA Kyoko 桑原京子

新井京子アライキョウコ

ARAI Kyoko 新井京子

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Researcher Number	10167976
Other IDs
Affiliation (Current)	2025: 順天堂大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2021: 順天堂大学, 医学部, 非常勤講師 2010 – 2020: Juntendo University, 医学部, 准教授 2007 – 2010: Juntendo University, School of Medicine, Assistant Professor 2003 – 2006: 順天堂大学, 医学部, 助手 1997 – 1998: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Public health/Health science Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including Mycology) / Bacteriology (including mycology)
Keywords	Principal Investigator 市中獲得型 MRSA / MLST / 健康成人 / 健康な子供 / MRC-NNS / 市中獲得型MRSA / SCCmec / MRC-NS / CA-MRSA Except Principal Investigator 敗血症 … More / 好中球 / 抗菌ペプチド / エンドトキシン / alarmin / アポトーシス / Apoptosis / Sepsis / Toll-like receptor / PFGE / MLST / hetero-VRSA / VRSA / サイトカイン / 細胞死 / マクロファージ / microparticle / cathelicidin / ectosome / エクソソーム / 生体防御ペプチド / アラーミン / 細胞外小胞 / LL-37 / エクトソーム / Lipopolvsaccharide / Endotoxin shock / Defensins / Cathelicidin / Antimicrobial peptides / Neutrophils / アナンダミド / マクロファージ・単球 / リボ多糖(LPS) / HMGB(high mobility group& / 細菌 / 感染症 / デフェンシン / cathelicidins / リポ多糖(LPS) / エンドトキシンショック / Integrins / Macrophage / Monocyte / Cytokine / Endotoxin / Neutrophil / インテグリン / 単球・マクロファージ / Coagulase typing / SCC mec / Healthy / Healthy children / Hospital MRSA / Community aquired MRSA / フィールド調査 / 健康キャリアー / 小児 / ブドウ球菌 / メチシリン耐性遺伝子 / 市中感染 / MRSA / 院内獲得型MRSA / 看護師 / MRC-NS / コアグラーゼ型 / SCCmec / 健康成人 / 一般健康児 / 病院内獲得型MRSA / 市中獲得型MRSA / glycopeptide / teicoplanin / cell wall / peptidoglycan / Staphylococcus aureus / vancomycin / 細胞壁合成 / genotyping / PBP / 疫学 / ムレインモノアー / hetero- VRSA / 併用療法 / 細胞集団解析 / affinity trapping / ムレインモノマー / バンコマイシン耐性 / 感染防御・制御 / リポ多糖 / DAMPs / NETs / カスパーゼ / ピロトーシス / alrmin / HMGB-1 / 血管内皮細胞 Less

Regulation of sepsis by alarmin that induces the release of ectosomes with antibacterial potential from neutrophils
- Principal Investigator
  
  Nagaoka Isao
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Roles of NETs and alarmins in the pathogenesis of sepsis
- Principal Investigator
  
  NAGAOKA ISAO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Modulation of a novel death, pyroptosis by alarmins in septic shock
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of host cell apoptosis during sepsis by alarmins
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Trends and Molecular Epidemiological Analysis of Community-associated MRSA isolated from healthy children and adultsPrincipal Investigator
- Principal Investigator
  
  KUWAHARA Kyoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Juntendo University
Molecular mechanism for the regulation of septic shock by endogenous antimicrobial cathelicidin peptides
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of neutrophil apoptosis in septic shock and its regulation by endogenous antimicrobial peptides
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  JUNTENDO UNIVERSITY
Observation with time of the rise and fall of community-acquired MRSA and its pathogenicinvestigation
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  JUNTENDO UNIVERSITY
Emergence of vancomycin-resistant MRSA and its countermesures
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University

All 2021 2020 2019 2018 2017 2016 2014 2011 2010 2009 2008 2007 2005

All Journal Article Presentation Book

[Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡　功
- Total Pages
  82
- Publisher
  医学図書出版株式会社
- ISBN
- Data Source
  KAKENHI-PROJECT-17K08840
[Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils2020
- Author(s)
  Kumagai Y, Murakami T, Kuwahara-Arai, Iba T, Reich J, Nagaoka I
- Journal Title
  
  Innate Immun
  
  Volume: 26 Issue: 7 Pages: 565-579
- DOI
  10.1177/1753425920936754
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-19K07562, KAKENHI-PROJECT-20K07486
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model.2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Molecular Medicine Reports
  
  Volume: 16 Issue: 4 Pages: 5618-5626
- DOI
  10.3892/mmr.2017.7267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide.2017
- Author(s)
  Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I.
- Journal Title
  
  Int J Mol Med.
  
  Volume: in press Issue: 3 Pages: 549-558
- DOI
  10.3892/ijmm.2017.2870
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model.2017
- Author(s)
  Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K
- Journal Title
  
  Experimental and Therapeutic Medicine
  
  Volume: 13 Issue: 6 Pages: 2969-2974
- DOI
  10.3892/etm.2017.4308
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Mol Med Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Human host defense cathelicidin peptide LL-37 enhances the lipopolysaccharide uptake by liver sinusoidal endothelial cells without cell activation.2016
- Author(s)
  Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  J Immunol
  
  Volume: 196 Issue: 3 Pages: 1338-1347
- DOI
  10.4049/jimmunol.1403203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice.2016
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  Int Immunol
  
  Volume: 28 Issue: 5 Pages: 245-253
- DOI
  10.1093/intimm/dxv113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I.
- Journal Title
  
  PLoS One
  
  Volume: 9 Issue: 1 Pages: e85765-e85765
- DOI
  10.1371/journal.pone.0085765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Human antimicrobial cathelicidin peptide LL-37 suppresses the lipopolysaccharide-induced apoptosis of endothelial cell.2011
- Author(s)
  Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
- Journal Title
  
  Int Imunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590456
[Journal Article] Human antimicrobial cathelicidin peptide LL-37 suppresses the lipopolysaccharide-induced apoptosis of endothelial cells2011
- Author(s)
  Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
- Journal Title
  
  Int Immunol
  
  Volume: 23 Issue: 3 Pages: 185-193
- DOI
  10.1093/intimm/dxq471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Augmentation of the antimicrobial activities of guinea pig cathelicidin CAP11-derived peptides by amino acid substitutions.2009
- Author(s)
  Okuda D, Yomogida S, Kuwahara-Arai K, Hitamatsu K, Tamura H, Nagaoka I
- Journal Title
  
  Int J Mol Med 23
  
  Pages: 501-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590456
[Journal Article] Antibacterial cathelicidin peptide CAP 11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes2007
- Author(s)
  Murakami, T, Yomogida, S, Someya, A, Kuwahara-Arai, K, Tamura, H, Nagaoka, I
- Journal Title
  
  FEBS Lett 581
  
  Pages: 140-144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590401
[Journal Article] Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.2005
- Author(s)
  Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M
- Journal Title
  
  Inflamm Res 54
  
  Pages: 66-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590400
[Presentation] 生体防御ペプチドLL-37は、抗菌活性を有する細胞外小胞の放出を介してマウス敗血症の病態改善をする2021
- Author(s)
  熊谷由美, 角田宗一郎, 桒原京子, 長岡　功
- Organizer
  第94回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] LL-37 ameliorates mouse sepsis by inducing the secretion of antibacterial extracellular vesicles2021
- Author(s)
  Kumagai Y, Kakuta S, Kuwahara K, Susaki E, Nagaoka I
- Organizer
  10th Annual Meeting ISEV (International Society of Extracellular Vesicles) 2021
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] Antimicrobial peptide LL-37 induces neutrophil-derived extracellular vesicles with antibacterial potential and protects murine sepsis2020
- Author(s)
  Kumagai Y, Murakami T, Kuwahara K, Nagaoka I
- Organizer
  ISEV (International Society of Extracellular Vesicles) 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] Antimicrobial peptide LL-37 induces antibacterial ectosomes from neutrophils2020
- Author(s)
  熊谷由美, 村上泰介, 桑原京子, 長岡　功
- Organizer
  第93回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 抗菌ペプチドLL-37による好中球細胞外（エクトソーム）の放出を介したマウス敗血症の病態改善2019
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, 長岡　功
- Organizer
  第6回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] Antimicrobial peptide LL-37 ameliorates mouse sepsis through microparticle release from neutrophils2019
- Author(s)
  熊谷由美, 村上泰介, 桑原京子, 長岡　功
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 好中球細胞外小胞の産生を介したLL-37によるマウス敗血症の病態改善.2018
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, 射場敏明, 長岡　功
- Organizer
  第101回日本細菌学会関東支部総会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 抗菌ペプチドLL-37による好中球細胞外小胞（エクトソーム）の産生を介したマウス敗血症の病態改善.2018
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡　功
- Organizer
  第24回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] LPSで誘導される血管内皮細胞のアポトーシスに対するヒト抗菌ペプチドLL-37の抑制効果2010
- Author(s)
  鈴木香,栞原京子,射場敏明,山倉文幸,田村弘志,村上泰介,細田浩司,長岡功
- Organizer
  第57回毒素シンポジウム予稿集(60-62)
- Place of Presentation
  長浜
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] 健康な子供の鼻腔に存在するメチシリン耐性ブドウ球菌の調査2009
- Author(s)
  桑原京子
- Organizer
  日本感染症学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] 東京都内某保育園のこどもから分離されたMRSAおよびMRC-NSの分子疫学的解析2009
- Author(s)
  桑原京子
- Organizer
  日本化学療法学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] Cathelicidinファミリー抗菌ペプチドLL-37はLPSで誘導される血管内皮細胞のアポトーシスを抑制する2009
- Author(s)
  鈴木香,渋沢謙太郎,栞原京子,射場敏明,山倉文幸,田村弘志,長岡功
- Organizer
  生化学81:200,396,第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] 東京都内某保育園の子供から分離されたMRSAおよびMRC-NSの分子疫学的解析2008
- Author(s)
  桑原京子、椿下早絵、廣瀧慎一郎、清水俊明、平松啓一
- Organizer
  順天堂大学医学部細菌学、感染制御科学、小児科化学療法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] 健康な子供の鼻腔に存在するメチシリン耐性ブドウ球菌の調査2008
- Author(s)
  桑原京子、椿下早絵、廣瀧慎一郎、清水俊明、平松啓一
- Organizer
  順天堂大学医学部細菌学、感染制御科学、小児科感染症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658

1. NAGAOKA Isao (60164399)

# of Collaborated Projects: 6 results

# of Collaborated Products: 23 results
2. IBA Toshiaki (40193635)

# of Collaborated Projects: 4 results

# of Collaborated Products: 10 results
3. HIRAMATSU Keiichi (10173262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHIMIZU Toshiaki (30260889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SUZUKI Kaori (90631929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
6. TABE Yoko (70306968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SASAKI Kazumi (90276478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HANAKI Hideaki (60286747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITO Teruyo (10095763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAMOTO Munetaka (50338414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MURAKAMI Taisuke (40384135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 堀典子 (50245700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HU Zhongshuang

# of Collaborated Projects: 1 results

# of Collaborated Products: 4 results
14. KONDO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Kuwahara Kyoko 桑原 京子

KUWAHARA Kyoko 桑原 京子

新井 京子 アライ キョウコ

ARAI Kyoko 新井 京子

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Trends and Molecular Epidemiological Analysis of Community-associated MRSA isolated from healthy children and adultsPrincipal Investigator

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[Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019

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[Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils2020

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[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model.2017

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[Journal Article] Neutrophil extracellular traps induce IL-1β production by macrophages in combination with lipopolysaccharide.2017

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[Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model.2017

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[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model2017

Kuwahara Kyoko 桑原京子

KUWAHARA Kyoko 桑原京子

新井京子アライキョウコ

ARAI Kyoko 新井京子