Kuwahara Kyoko 桑原京子

… Alternative Names

Researcher Number	10167976
Other IDs
Affiliation (Current)	2022: 順天堂大学, 医学部, 非常勤講師
Affiliation (based on the past Project Information) *help	2010 – 2020: Juntendo University, 医学部, 准教授 2007 – 2010: Juntendo University, School of Medicine, Assistant Professor 2003 – 2006: 順天堂大学, 医学部, 助手 1997 – 1998: 順天堂大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Public health/Health science Except Principal Investigator Bacteriology (including Mycology) / Bacteriology (including mycology) / Bacteriology (including Mycology)
Keywords	Principal Investigator CA-MRSA / MRC-NS / SCCmec / 市中獲得型MRSA / MRC-NNS / 健康な子供 / 健康成人 / MLST / 市中獲得型 MRSA Except Principal Investigator 敗血症 … More

好中球エクトソームと危険信号分子アラーミンに着目した敗血症の新たな病態制御
- Principal Investigator
  
  長岡功
- Project Period (FY)
  2017 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Roles of NETs and alarmins in the pathogenesis of sepsis
- Principal Investigator
  
  NAGAOKA ISAO
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including mycology)
- Research Institution
  Juntendo University
Modulation of a novel death, pyroptosis by alarmins in septic shock
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of host cell apoptosis during sepsis by alarmins
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Trends and Molecular Epidemiological Analysis of Community-associated MRSA isolated from healthy children and adultsPrincipal Investigator
- Principal Investigator
  
  KUWAHARA Kyoko
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Public health/Health science
- Research Institution
  Juntendo University
Molecular mechanism for the regulation of septic shock by endogenous antimicrobial cathelicidin peptides
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2005 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University
Modulation of neutrophil apoptosis in septic shock and its regulation by endogenous antimicrobial peptides
- Principal Investigator
  
  NAGAOKA Isao
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  JUNTENDO UNIVERSITY
Observation with time of the rise and fall of community-acquired MRSA and its pathogenicinvestigation
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  2002 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  JUNTENDO UNIVERSITY
Emergence of vancomycin-resistant MRSA and its countermesures
- Principal Investigator
  
  HIRAMATSU Keiichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Bacteriology (including Mycology)
- Research Institution
  Juntendo University

All 2020 2019 2018 2017 2016 2014 2011 2010 2009 2008 2007 2005

All Journal Article Presentation Book

[Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡　功
- Total Pages
  82
- Publisher
  医学図書出版株式会社
- ISBN
- Data Source
  KAKENHI-PROJECT-17K08840
[Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils.2020
- Author(s)
  Kumagai Y, Murakami T, Kuwahara-Arai, Iba T, Reich J, Nagaoka I
- Journal Title
  
  Innate Immunity
  
  Volume: 26 Pages: 565-579
- DOI
  10.1177/1753425920936754
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-19K07562, KAKENHI-PROJECT-20K07486
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory response in a mouse septic model2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Mol Med Rep
  
  Volume: 16 Pages: 5618-5626
- DOI
  10.3892/mmr.2017.7267
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840
[Journal Article] Neutrophil extracellular traps (NETs) induces the IL-1β production by macrophages in combination with lipopolysaccharide.2017
- Author(s)
  Hu Z, Murakami T, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoka I.
- Journal Title
  
  Int J Mol Med
  
  Volume: in press Pages: 549-558
- DOI
  10.3892/ijmm.2017.2870
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15K08653, KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model2017
- Author(s)
  Takehara K, Murakami T, Kuwahara-Arai K, Iba T, Nagaoka I, Sakamoto K
- Journal Title
  
  Exp Ther Med
  
  Volume: 13 Pages: 2969-2974
- DOI
  10.3892/etm.2017.4308
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-16K08789, KAKENHI-PROJECT-17K08840, KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model2017
- Author(s)
  Hosoda H, Nakamura K, Hu Z, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Tabe Y, Nagaoaka I
- Journal Title
  
  Mol Med Reports
  
  Volume: 印刷中
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Human host defense cathelicidin peptide LL-37 enhances the lipopolysaccharide uptake by liver sinusoidal endothelial cells without cell activation.2016
- Author(s)
  Suzuki K, Murakami T, Hu Z, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  J Immunol
  
  Volume: 196 Pages: 1338-1347
- DOI
  10.4049/jimmunol.1403203
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice.2016
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Reich J, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  Int Immunol
  
  Volume: 28 Pages: 245-253
- DOI
  10.1093/intimm/dxv113
- Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26460538, KAKENHI-PROJECT-16K08789
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-26460538
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism.2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I.
- Journal Title
  
  PLoS One
  
  Volume: 9
- DOI
  10.1371/journal.pone.0085765
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATP-induced pyroptosis of macrophages by dual mechanism2014
- Author(s)
  Hu Z, Murakami T, Suzuki K, Tamura H, Kuwahara-Arai K, Iba T, Nagaoka I
- Journal Title
  
  PLOS ONE
  
  Volume: 9(1)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Human antimicrobial cathelicidin peptide LL-37 suppresses the lipopolysaccharide-induced apoptosis of endothelial cell.2011
- Author(s)
  Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
- Journal Title
  
  Int Imunol (in press)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590456
[Journal Article] Human antimicrobial cathelicidin peptide LL-372011
- Author(s)
  Suzuki K, Murakami T, Kuwahara-Arai K, Tamura H, Hiramatsu K, Nagaoka I
- Journal Title
  
  International Immunology
  
  Volume: 23 Pages: 185-193
- DOI
  10.1093/intimm/dxq471
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590519
[Journal Article] Augmentation of the antimicrobial activities of guinea pig cathelicidin CAP11-derived peptides by amino acid substitutions.2009
- Author(s)
  Okuda D, Yomogida S, Kuwahara-Arai K, Hitamatsu K, Tamura H, Nagaoka I
- Journal Title
  
  Int J Mol Med 23
  
  Pages: 501-508
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20590456
[Journal Article] Antibacterial cathelicidin peptide CAP 11 suppresses the anandamide production from lipopolysaccharide-stimulated mononuclear phagocytes2007
- Author(s)
  Murakami, T, Yomogida, S, Someya, A, Kuwahara-Arai, K, Tamura, H, Nagaoka, I
- Journal Title
  
  FEBS Lett 581
  
  Pages: 140-144
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590401
[Journal Article] Augmentation of the bactericidal activities of human cathelicidin CAP18/LL-37-derived antimicrobial peptides by amino acid substitutions.2005
- Author(s)
  Nagaoka I, Kuwahara-Arai K, Tamura H, Hiramatsu K, Hirata M
- Journal Title
  
  Inflamm Res 54
  
  Pages: 66-73
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590400
[Presentation] Antimicrobial peptide LL-37 induces neutrophil-derived extracellular vesicles with antibacterial potential and protects murine sepsis2020
- Author(s)
  Kumagai Y, Murakami T, Kuwahara K, Nagaoka I
- Organizer
  ISEV (International Society of Extracellular Vesicles) 2020
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] Antimicrobial peptide LL-37 induces antibacterial ectosomes from neutrophils2020
- Author(s)
  熊谷由美, 村上泰介, 桑原京子, 長岡　功
- Organizer
  第93回日本細菌学会総会
- Invited
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 抗菌ペプチドLL-37による好中球細胞外（エクトソーム）の放出を介したマウス敗血症の病態改善2019
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, 長岡　功
- Organizer
  第6回日本細胞外小胞学会学術集会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] Antimicrobial peptide LL-37 ameliorates mouse sepsis through microparticle release from neutrophils2019
- Author(s)
  熊谷由美, 村上泰介, 桑原京子, 長岡　功
- Organizer
  第92回日本細菌学会総会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 好中球細胞外小胞の産生を介したLL-37によるマウス敗血症の病態改善.2018
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, 射場敏明, 長岡　功
- Organizer
  第101回日本細菌学会関東支部総会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] 抗菌ペプチドLL-37による好中球細胞外小胞（エクトソーム）の産生を介したマウス敗血症の病態改善.2018
- Author(s)
  熊谷由美, 村上泰介, 桒原京子, Reich Johannes, 田村弘志, 長岡　功
- Organizer
  第24回日本エンドトキシン・自然免疫研究会
- Data Source
  KAKENHI-PROJECT-17K08840
[Presentation] LPSで誘導される血管内皮細胞のアポトーシスに対するヒト抗菌ペプチドLL-37の抑制効果2010
- Author(s)
  鈴木香,栞原京子,射場敏明,山倉文幸,田村弘志,村上泰介,細田浩司,長岡功
- Organizer
  第57回毒素シンポジウム予稿集(60-62)
- Place of Presentation
  長浜
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] 健康な子供の鼻腔に存在するメチシリン耐性ブドウ球菌の調査2009
- Author(s)
  桑原京子
- Organizer
  日本感染症学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] 東京都内某保育園のこどもから分離されたMRSAおよびMRC-NSの分子疫学的解析2009
- Author(s)
  桑原京子
- Organizer
  日本化学療法学会総会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] Cathelicidinファミリー抗菌ペプチドLL-37はLPSで誘導される血管内皮細胞のアポトーシスを抑制する2009
- Author(s)
  鈴木香,渋沢謙太郎,栞原京子,射場敏明,山倉文幸,田村弘志,長岡功
- Organizer
  生化学81:200,396,第82回日本生化学会大会
- Place of Presentation
  神戸
- Data Source
  KAKENHI-PROJECT-20590456
[Presentation] 東京都内某保育園の子供から分離されたMRSAおよびMRC-NSの分子疫学的解析2008
- Author(s)
  桑原京子、椿下早絵、廣瀧慎一郎、清水俊明、平松啓一
- Organizer
  順天堂大学医学部細菌学、感染制御科学、小児科化学療法学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658
[Presentation] 健康な子供の鼻腔に存在するメチシリン耐性ブドウ球菌の調査2008
- Author(s)
  桑原京子、椿下早絵、廣瀧慎一郎、清水俊明、平松啓一
- Organizer
  順天堂大学医学部細菌学、感染制御科学、小児科感染症学会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-20590658

1. NAGAOKA Isao (60164399)

# of Collaborated Projects: 6 results

# of Collaborated Products: 22 results
2. IBA Toshiaki (40193635)

# of Collaborated Projects: 4 results

# of Collaborated Products: 13 results
3. HIRAMATSU Keiichi (10173262)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. SHIMIZU Toshiaki (30260889)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. SUZUKI Kaori (90631929)

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
6. TABE Yoko (70306968)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
7. SASAKI Kazumi (90276478)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. HANAKI Hideaki (60286747)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. ITO Teruyo (10095763)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. YAMAMOTO Munetaka (50338414)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. MURAKAMI Taisuke (40384135)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
12. 堀典子 (50245700)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. HU Zhongshuang

# of Collaborated Projects: 1 results

# of Collaborated Products: 5 results
14. KONDO Noriko

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. 熊谷由美

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Kuwahara Kyoko 桑原 京子

KUWAHARA Kyoko 桑原 京子

新井 京子 アライ キョウコ

ARAI Kyoko 新井 京子

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Trends and Molecular Epidemiological Analysis of Community-associated MRSA isolated from healthy children and adultsPrincipal Investigator

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[Book] エンドトキシン・自然免疫研究22 -エンドトキシン・自然免疫研究の新たな可能性を求めて2019

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[Journal Article] Antimicrobial peptide LL-37 ameliorates a murine sepsis model via the induction of microvesicle release from neutrophils.2020

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[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory response in a mouse septic model2017

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[Journal Article] Neutrophil extracellular traps (NETs) induces the IL-1β production by macrophages in combination with lipopolysaccharide.2017

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[Journal Article] Evaluation of the effect of recombinant thrombomodulin on a lipopolysaccharide-induced murine sepsis model2017

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[Journal Article] Antimicrobial cathelicidin peptide LL-37 induces NET formation and suppresses the inflammatory responses in a mouse septic model2017

Kuwahara Kyoko 桑原京子

KUWAHARA Kyoko 桑原京子

新井京子アライキョウコ

ARAI Kyoko 新井京子