UTSUMI Toshiaki 内海俊明

… Alternative Names

内海俊明ウツミトシアキ

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Researcher Number	10176711
Other IDs
Affiliation (based on the past Project Information) *help	2019 – 2021: 藤田医科大学, 医学部, 教授 2015: 藤田保健衛生大学医学部, 乳腺外科学, 教授 2014: 藤田保健衛生大学, 医学部乳腺外科, 教授 2009 – 2014: 藤田保健衛生大学, 医学部, 教授 2011: 藤田保健衛生大学, 医学部・乳腺外科, 教授 2000 – 2004: 藤田保健衛生大学, 医学部, 助教授 1995: 藤田保健衛生大学, 医学部, 講師
Review Section/Research Field	Principal Investigator General surgery Except Principal Investigator General surgery / Basic Section 55010:General surgery and pediatric surgery-related / Tumor diagnostics / Biological Sciences / Metabolomics
Keywords	Principal Investigator alternative splicing / breast cancer / aromatase gene Except Principal Investigator 乳癌 / アロマターゼ / エストロゲン / エストロゲン受容体 / ステロイドサルファターゼ / Akt / アロマターゼ阻害薬 … More / Rab / 薬剤耐性 / CDK4/6 / パルボシクリブ / 乳がん / 難治性乳がん治療 / 癌 / 品質管理機構 / mRNA / スプライシング / 遺伝子発現調節 / aromatase knockout mice / breast cancer / fluorescent probe / estrogen sulfotransferase / CVP IB 1 / steroid sulfatase / aromatase / estrogen / 組織特異的発現 / SNP / ノックアウトマウス / 発癌感受性 / 17β-水酸化ステロイド脱水素酵素 / ホルモン療法 / Cyp1B1 / トランスジェニックマウス / 炎症性サイトカイン / OAT-3 / siRNA / GFP / ナロマターゼ / 細胞間相互作用 / エストロゲン依存性癌 / アロマターゼ欠損マウス / 蛍光プローブ / エストロゲン硫酸転移酵素 / cyp1B1 / RNAスプライシング / RNA結合蛋白質 / 選択的スプライシング / 癌遺伝子産物 / 乳腺外科学 / HMGA1a / ストロゲン受容体 / 内分泌外科学 / ホルモン依存性腫瘍 Less

Overcoming Molecular Targeted Drug Resistance in Aromatase Inhibitor-Resistant Breast Cancer.
- Principal Investigator
  
  Hikichi Masahiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Fujita Health University
Search for the cause of proteomic disorder without genomic mutations in the global mis-regulation of splicing
- Principal Investigator
  
  MAYEDA Akila
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Tumor diagnostics
- Research Institution
  Fujita Health University
Exploring a novel therapy of hormone-resistant breast cancer by short RNA
- Principal Investigator
  
  OHE Kenji
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Kyoto University
Regulation of Estrogen Receptor Alpha through novel function of HMGA1a.-Towards a novel breast cancer therapy-
- Principal Investigator
  
  OHE Kenji
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Fujita Health University
エストロゲン依存性癌におけるエストロゲン生合成と代謝に関する研究
- Principal Investigator
  
  坂本秀生
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Fujita Health University
Study on the protection against estrogen-dependent cancer
- Principal Investigator
  
  HARADA Nobuhiro
- Project Period (FY)
  2000 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  藤田保健衛生大学
乳癌組織のaromataseの発現調節に関する基礎的検討Principal Investigator
- Principal Investigator
  
  内海俊明
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  General surgery
- Research Institution
  Fujita Health University

All 2020 2013 2012 2011 2010 2009 2000

All Journal Article Presentation

[Journal Article] Upregulation of CIP2A in estrogen depletion‐resistant breast cancer cells treated with low‐dose everolimus2020
- Author(s)
  Nishio Eiji、Hayashi Takanori、Akaza Mao、Hisatomi Yukiko、Hikichi Masahiro、Fujii Takuma、Utsumi Toshiaki、Harada Nobuhiro、Shimono Yohei
- Journal Title
  
  FEBS Open Bio
  
  Volume: 10 Issue: 10 Pages: 2072-2080
- DOI
  10.1002/2211-5463.12956
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-19K09084, KAKENHI-PROJECT-20K09681, KAKENHI-PROJECT-18K07231
[Journal Article] Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol2011
- Author(s)
  Honma N, Saji S, Hirose M, Horiguchi SI, Kuroi K, Hayashi SI, Utsumi T, Harada N.
- Journal Title
  
  Cancer Sci
  
  Volume: 102 Pages: 1848-1854
- NAID
  10030244004
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years2009
- Author(s)
  Honma N, Takubo K, Sawabe M, Arai T, Akiyama F, Sakamoto G, Utsumi T, Yoshimura N, Harada N
- Journal Title
  
  Breast Cancer Res
  
  Volume: 11(4)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients2009
- Author(s)
  Suzuki M, Ishida H, Shiotsu Y, Nakata T, Akinaga S, Takashima S, Utsumi T, Saeki T, Harada N
- Journal Title
  
  J Steroid Biochem Mol Biol
  
  Volume: 113 Pages: 195-201
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591679
[Journal Article] Correlation of cyclin D1 mRNA levels with clinico-pathological parameters and clinical outcome in human breast carcinoma.2000
- Author(s)
  Utsumi T, Yoshimura N, Maruta M, Mizoguchi Y, Harada N.
- Journal Title
  
  Int.J.Cancer 89
  
  Pages: 39-43
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213132
[Journal Article] Elevated steroid sulfatase expression in breast cancers.2000
- Author(s)
  Utsumi T, Yoshimura N, Takeuchi S, Maruta M, Maeda K, Harada, N.
- Journal Title
  
  J.Steroid Biochem.Mol.Biol. 73
  
  Pages: 141-145
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-12213132
[Journal Article] Correlation of cyclin D1 mRNA levels with clinicopathological parameters and clinical outcome in human breast carcinoma2000
- Author(s)
  Utsumi T
- Journal Title
  
  Int.J.Cancer 89
  
  Pages: 39-43
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-12213132
[Presentation] Sequence-specific RNA-binding of HMGA1a may play a role in acquired resistance of estrogen receptor-positive breast carcinoma2013
- Author(s)
  Kenji Ohe, Shinsuke Miyajima, Kanako Kuwasako, Yutaka Muto, Toshiaki Utsumi, Masatoshi Hagiwara, Akila Mayeda
- Organizer
  2013 CSHL Meeting on Eukaryotic mRNA Processing
- Place of Presentation
  コールドスプリングハーバー、ニューヨーク、米国
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] 乳癌における癌遺伝子産物HMGA1aによるERα46 の発現調節機構2012
- Author(s)
  宮島慎介、大江賢治、牛窓かおり、引地理浩、小林尚美、前田明、内海俊明
- Organizer
  第20回　日本乳癌学会学術総会
- Place of Presentation
  熊本市民会館
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体アルファ-46（ERα46）の選択的スプライシング改変により腫瘍増殖を促進する2012
- Author(s)
  大江賢治、宮島慎介、内海俊明
- Organizer
  第85回　日本内分泌学会学術総会
- Place of Presentation
  名古屋国際会議場
- Data Source
  KAKENHI-PROJECT-24591920
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  大江賢治, 内海俊明, 前田明
- Organizer
  14th International Congress of Endocrinology
- Place of Presentation
  京都市、国立京都国際会館
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体αの異常スプライシングを是正する2010
- Author(s)
  江賢治、内海俊明、前田明
- Organizer
  第18回日本ステロイドホルモン学会年会
- Place of Presentation
  名古屋市
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, kila Mayeda
- Organizer
  14^<th> International Congress of Endocrinology
- Place of Presentation
  京都市、国立京都国際会館
- Year and Date
  2010-03-26
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  第6回国際ホルモン依存性癌シンポジウム
- Place of Presentation
  千葉、シエラトン・グランデ・トーキョーベイ・ホテル
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体αの異常スプライシングを是正する2010
- Author(s)
  大江賢治、内海俊明、前田明
- Organizer
  第18回日本ステロイドホルモン学会年会
- Place of Presentation
  名古屋市、WINC AICHI
- Year and Date
  2010-11-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] HMGA1a induces aberrant splicing of Estrogen Receptor α in MCF-7 breast cancer cells2010
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  第6回国際ホルモン依存性癌シンポジウム
- Place of Presentation
  シエラトン・グランデ・トーキョーベイ・ホテル
- Year and Date
  2010-09-12
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] 癌遺伝子産物HMGA1が、乳癌においてエストロゲン受容体αの異常スプライシングの誘導因子として機能しているかもしれない!2009
- Author(s)
  大江賢治、内海俊明、前田明
- Organizer
  第11回日本RNA学会年会
- Place of Presentation
  新潟市
- Year and Date
  2009-07-27
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] 癌遺伝子産物HMGA1が、乳癌においてエストロゲン受容体αの異常スプライシングの誘導因子として機能しているかもしれない!2009
- Author(s)
  大江賢治, 内海俊明, 前田明
- Organizer
  第11回日本RNA学会年会
- Place of Presentation
  新潟市、朱鷺メッセ
- Data Source
  KAKENHI-PROJECT-21591679
[Presentation] Oncogenic Product HMGA1a Might Function as Aberrant Splicing Inducer of Estrogen Receptor α in Breast Cancer2009
- Author(s)
  Kenji Ohe, Toshiaki Utsumi, Akila Mayeda
- Organizer
  2009 EUKARYOTIC mRNA PROCESSING meeting(Cold Spring Harbor Laboratory meeting)
- Place of Presentation
  ニューヨーク州、コールド・スプリング・ハーバー
- Year and Date
  2009-08-18
- Data Source
  KAKENHI-PROJECT-21591679

1. MAYEDA Akila (50212204)

# of Collaborated Projects: 3 results

# of Collaborated Products: 11 results
2. HONDA Shin-ichiro (40257639)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. HARADA Nobuhiro (00189705)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
4. OHE Kenji (30419527)

# of Collaborated Projects: 2 results

# of Collaborated Products: 11 results
5. HAYASHI Shin-ichi (60144862)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. KAMEYAMA Toshiki (60298544)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. SHIROKI Ryoichi (70226330)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. SUGIOKA Atsushi (20171150)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. Hikichi Masahiro (80794130)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
10. 坂本秀生 (30225817)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 佐々木恵美 (20178635)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 林孝典 (40724315)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
13. 下野洋平 (90594630)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
14. 喜島祐子 (60381175)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

UTSUMI Toshiaki 内海 俊明

内海 俊明 ウツミ トシアキ

Research Projects

Research Products

Co-Researchers

Overcoming Molecular Targeted Drug Resistance in Aromatase Inhibitor-Resistant Breast Cancer.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Search for the cause of proteomic disorder without genomic mutations in the global mis-regulation of splicing

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Exploring a novel therapy of hormone-resistant breast cancer by short RNA

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Regulation of Estrogen Receptor Alpha through novel function of HMGA1a.-Towards a novel breast cancer therapy-

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

エストロゲン依存性癌におけるエストロゲン生合成と代謝に関する研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on the protection against estrogen-dependent cancer

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

乳癌組織のaromataseの発現調節に関する基礎的検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Upregulation of CIP2A in estrogen depletion‐resistant breast cancer cells treated with low‐dose everolimus2020

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol2011

Author(s)

Journal Title

NAID

Data Source

[Journal Article] Alternative use of multiple exons 1 of aromatase gene in cancerous and normal breast tissues from women over the age of 80 years2009

Author(s)

Journal Title

Data Source

[Journal Article] Expression level of enzymes related to in situ estrogen synthesis and clinicopathological parameters in breast cancer patients2009

Author(s)

Journal Title

Data Source

[Journal Article] Correlation of cyclin D1 mRNA levels with clinico-pathological parameters and clinical outcome in human breast carcinoma.2000

Author(s)

Journal Title

Description

Data Source

[Journal Article] Elevated steroid sulfatase expression in breast cancers.2000

Author(s)

Journal Title

Description

Data Source

[Journal Article] Correlation of cyclin D1 mRNA levels with clinicopathological parameters and clinical outcome in human breast carcinoma2000

Author(s)

Journal Title

Description

Data Source

UTSUMI Toshiaki 内海俊明

内海俊明ウツミトシアキ

[Presentation] HMGA1に対する「おとり」RNAは、エストロゲン受容体アルファ-46（ERα46）の選択的スプライシング改変により腫瘍増殖を促進する2012