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KAWASHIMA Seinosuke  川嶋 成乃亮

ORCIDConnect your ORCID iD *help
Researcher Number 10177678
Other IDs
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Affiliation (based on the past Project Information) *help 2006: Kobe University, Graduate School of Medicine, Medical researcher, 大学院・医学系研究科循環呼吸器病態学, 医学研究員
2006: 神戸大学, 大学院医学系研究科, 医学研究員
2001 – 2005: Kobe University, Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Associate Professor, 大学院・医学系研究科, 助教授
2003: Kobe University Graduate School of Medicine, Division of Cardiovascular and Respiratory Medicine, Department of Internal Medicine, Associate Professor, 大学院・医学研究科, 助教授
2001: 神戸大学, 大学院・医学系研究科, 教授 … More
2000 – 2001: Kobe University, School of medicine, associate professor, 医学部, 助教授
1998 – 1999: Kobe Univ, Hospital.Lecturer, 医学部・附属病院, 講師
1998: 神戸大学, 医学部, 講師
1998: 神戸大学, 医学部附属病院, 講師
1995 – 1997: Kobe University School of Medicine The 1st Department of Internal Medicine Assos, 医学部・付属病院, 講師
1996: 神戸大学, 医学部附属病院, 講師
1995 – 1996: 神戸大学, 医学部・附属病院, 講師
1992 – 1994: Kobe university School of Medicine First Department of Medicine Assistant Professor, 医学部, 助手
1990 – 1991: 兵庫医科大学, 医学部, 助手 Less
Review Section/Research Field
Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Except Principal Investigator
Circulatory organs internal medicine / Circulatory organs internal medicine
Keywords
Principal Investigator
心筋細胞 / 遺伝子導入 / 一酸化窒素 / 心筋炎 / エンドセリン / Rho / 心肥大 / 細胞移植 / reperfusion / 心不全 … More / heart failure / cardiotrophin-1 / 酸化低比重リポ蛋白質 / 血管内皮細胞 / NO合成酵素 / 内皮由来血管弛緩因子 / 低比重リポ蛋白質 / リゾホスファチジルコリン / 遺伝性高脂血症家兎 / インターフェロン / 一酸化窒素合成酵素 / 細胞接着 / エンドセリン変換酵素 / 培養内皮細胞 / 心血管疾患 / 低分子量G蛋白質 / c-fos / c-fos遺伝子 / 分化 / 骨髄細胞 / Y染色体 / Infarct Expansion / Infarct Healing / SHR / Repirfusion / congestine Heart Failure / Rat / Reperfusion / Ventricular Remodeling / expansion / myocardial infarction / hypertension / 心筋梗塞 / 再潅流 / ラット / infarct expansion / infarct healing / congestive heart failure / rats / 酸化ストレス / 抗酸化薬 / 心筋細胞肥大 / p38MAPキナーゼ / 肥大 / p42 / p44MAPキナーゼ / oxidative stress / antioxidant / viral myocarditis / endothelin / cardiac hypertrophy / MAP kinase / 骨格筋芽細胞 / 不全心 / 遺伝子治療 / カルジオトロフィン / cell transpdlantation / myoblast / gene therapy / 動脈硬化 / 炎症 / Toll-like受容体 / 冠動脈疾患 / Toll-like 受容体 / 接着因子 / atherosclerosis / Toll-like receptor / coronary artery disease / carotid artery / rabbits / peripheral monocytes … More
Except Principal Investigator
動脈硬化 / 血管平滑筋細胞 / atherosclerosis / 活性酸素 / 内皮細胞 / 血管内皮細胞 / NO合成酵素 / NADH / NADPH oxidase / サイトカイン / リゾホスファチジルコリン / 増殖 / 血管リモデリング / vascular remodeling / マクロファージ / 酸化ストレス / 冠動脈 / glutathione peroxidase / superoxide / セロトニン / 一酸化窒素 / 一酸化窒素合成酵素 / シグナル伝達 / 遊走 / 内皮由来血管弛緩因子 / 高比重リポ蛋白質 / プロテインキナーゼC / 血管平滑筋 / 急性心筋梗塞 / トランスジェニックマウス / transgenic mice / アポトーシス / Vascular Smooth Muscle Cells / Proliferation / Migration / 内皮型NO合成酵素 / nitric oxide / 血管形成術後再狭窄 / 再狭窄 / 血管障害 / restenosis / macrophage / differentiation / NADH oxidase / cytokine / リパーゼ / リポ蛋白 / 平滑筋細胞 / 炎症 / lipase / lipoprotein / endothelial cell / smooth muscle cell / 血管内超音波画像法 / 冠攣縮 / ヒト冠動脈 / 組織性状 / 経時的形態的分析 / アルギニン / 血管作動物質 / アンジオテンシンll / MAPキナーゼ / 低分子量G蛋白 / 接着斑 / パキシリン / 低比重リポ蛋白質 / 細胞内Ca^<2+>濃度 / vascular endothelial cells / endothelium-derived relaxing factor / low density lipoprotein / high density lipoprotein / nitric synthase / protein kinase C / lysophosphatidylcholine / intracellular calcium concentration / 酸化低比重リポ蛋白 / 低比重リボ蛋白質 / 高比重リボ蛋白質 / リゾホスファチジツコリン / 細胞内Ca^2濃度 / Nitric oxide synthase / Oxidized low density lipoprotein / Lysophosphatidylcholine / Atherosclerosis / Vascular endothelial cells / Protein kinase C / 冠動脈萎縮 / 分子生物学 / 細胞内カルシウム濃度 / 冠動脈攣縮 / 遺伝子多型性 / serotonin / coronary spasm / vascular smooth muscle / molecular biology / intracellular calcium / acute myocardial infarction / polymorphism / 遺伝子工学 / nitric oxyde synthase / endthelial cell / genetic engineering / アンジオテンシンII / Vascular Remodeling / Angiotensin / Siganal Transduction / 血圧 / 血管拡張反応 / 敗血症性ショック / 接着因子 / 血管反応性 / eNOS / vascular response / septic shock / adhesion molecule / レプチン / OB-R / 細胞遊走 / 肥満 / 血管形成術後再挟窄 / 細胞増殖 / Leptin / Signal Transduction / MAP kinase / PI 3-kinase / 血管形成術 / 血管外膜細胞 / 単球 / 分化 / 筋原性転写因子 / angioplasty / adventitial cell / monocyte / carotid arteries / ズリ応力 / グルタシオンペルオキシダーゼ / チオレドキシン / グルタチオンペルオキシダーゼ / 酸化的ストレス / superoxide dismutase / MMP / shear stress / gene transfer / coronary artery / 冠動脈疾患 / 酸化LDL / 免疫染色法 / coronary artery disease / oxidized LDL / モレキュラークローニング / 高脂血症 / ELISA / HDL / coronary arteries / molecular cloning / カイロミクロンレムナント / MCP-1 / 血管内非細胞 / アポートシス / 細胞内シグナル伝達 / chylomicron remnants / endothelial cells / vascular smooth muscle cell / apoptosis / monocyte chemoattractant protein 1 / NAD(P)H oxidase / 虚血性心疾患 / Superoxide dismutase / 粥腫不安定化機構 / thioredoxin / 精神的ストレス / Coronary artery disease / SOD / Unstable plaque / テトラヒドロビオプテリン / 遺伝子操作マウス / スーパーオキシド / ジヒドロビオプテリン / GTPCH 1 / スパーオキシド / BH4 / apoE遺伝子欠損マウス / endothelial nitric oxide synthase / tetrahydrobiopterin / gene-engineered mice / 細胞分化 / 遺伝子治療 / ステント / ヒストン脱アセチル化酵素阻害剤 / p21蛋白 / gene therapy / stent / HDLコレステロール / 血管内皮 / リポ蛋白質 / ノックアウトマウス / 遺伝子多型 / inflammation / HDL cholesterol / knockout mouse Less
  • Research Projects

    (30 results)
  • Research Products

    (2 results)
  • Co-Researchers

    (12 People)
  •  Roll of Toll-like receptors in atherosclerotic lesion formationPrincipal Investigator

    • Principal Investigator
      KAWASHIMA Seinosuke
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  The role of endothelial lipase in pathogenesis of atherosclerosis : A novel therapeutic target for raising HDL cholesterol

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Balance-shift in the production of NO and superoxide via endothelial nitric oxide synthase in atherogenesis

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Gene therapy to prevent vascular remodeling-vascular smooth muscle cell as a target cell

    • Principal Investigator
      TANIGUCHI Takahiro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Development of ELISA system for plasma EDL and its clinical application for atherosclerosis

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Gene Therapy in Combination with Myoblast Transplantation for Global Non-ischemic Failing Hearts.Principal Investigator

    • Principal Investigator
      KAWASHIMA Seinosuke
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Role of chylomicron remnants in vascular remodeling

    • Principal Investigator
      ISHIKAWA Yuichi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Cross talk of oxidative and chronic mental stress in pathogenesis of coronary artery disease.

    • Principal Investigator
      INOUE Nobutaka
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  骨髄細胞による傷害心筋の修復〜細胞移植による不全心の治療法の開発〜Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      2000
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Role of Vascular NADH/NAPDH oxidase in atherogenesis

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      2000 – 2001
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Identification of Adventitial cells and Molecular Mechanisms of Phenotypic Modulation in the vasclar remodeling after bolloon injury

    • Principal Investigator
      TANIGUCHI Takahiro
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Regulation of Gene Expression of Antioxidative Enzymes in Vascular Cells and their Gene Transfer

    • Principal Investigator
      INOUE Nobutaka
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Analysis of the role of NO in cardiovascular disease by use of transgenic mice overexpressing endothelial NO synthase.

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Oxidative stress in heart failurePrincipal Investigator

    • Principal Investigator
      KAWASHIMA Seinosuke
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Regulation by Leptin of Vascular Smooth Muscle Cells Proliferation and Migration

    • Principal Investigator
      ISHIKAWA Yuichi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University School of Medicine
  •  血管内皮細胞機能制御の情報伝達機構とその脂質による修飾

    • Principal Investigator
      横山 光宏
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      Kobe University
  •  生体心筋内への遺伝子導入を用いた低分子量G蛋白質Rhoの心筋肥大への関与の検討Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      1997
    • Research Category
      Grant-in-Aid for Exploratory Research
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Vascular Smooth Muscle Cell Singnal Transduction in Vascular Remodeling

    • Principal Investigator
      TANIGUCHI Takahiro
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  心筋細胞肥大形成過程における低分子量G蛋白質Rho、Rasの関与Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  The role of endothelial nitric oxide synthase in cardiovascular regulation. -approach using genetic engineering.

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  エンドセリン変換酵素の調節機構ならびに病態モデルでのその発現の変化Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  血管収縮物質のシグナル伝達と血管平滑筋細胞の遊走、増殖の制御機構

    • Principal Investigator
      川原 康洋
    • Project Period (FY)
      1995
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  Serotonin receptors and ischemic heart disease

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1995 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  心筋細胞由来NOの病的心における病態的意義(細胞間接着ならびに心筋障害への影響)Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  血管平滑筋細胞における誘導型NO合成酵素の発現制御機構とその病態

    • Principal Investigator
      KAWAHARA Ysuhiro
    • Project Period (FY)
      1994
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  An approach to understand the pathophysiological role of endothelial constitutive nitric oxide synthase

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1994 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University School of Medicine
  •  血管内皮細胞におけるNO合成酵素の調節機構Principal Investigator

    • Principal Investigator
      川嶋 成乃亮
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  血管内超音波画像システムを用いたヒト冠動脈攣縮部位の経時的形態的分析

    • Principal Investigator
      SUEMATU Masakuni
    • Project Period (FY)
      1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  An approach to understand the interaction of lipoproteins and vascular endothelial cells

    • Principal Investigator
      YOKOYAMA Mitsuhiro
    • Project Period (FY)
      1992 – 1993
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
  •  An experimental study of infarct expansion and congestive heart failurePrincipal Investigator

    • Principal Investigator
      KAWASHIMA Seinosuke
    • Project Period (FY)
      1990 – 1992
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Circulatory organs internal medicine
    • Research Institution
      Kobe University
      Hyogo Medical University

All 2006

All Book

  • [Book] 循環器疾患と神経体液性因子2006

    • Author(s)
      川嶋 成乃亮
    • Total Pages
      181
    • Publisher
      メディカル・サイエンス・インターナショナル
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17590733
  • [Book] ?環器疾患と神経体液性因子2006

    • Author(s)
      川嶋 成乃亮
    • Total Pages
      181
    • Publisher
      メデイカル・サイエンス・インターナショナル
    • Data Source
      KAKENHI-PROJECT-17590733
  • 1.  YOKOYAMA Mitsuhiro (40135794)
    # of Collaborated Projects: 18 results
    # of Collaborated Products: 0 results
  • 2.  TANIGUCHI Takahiro (20263379)
    # of Collaborated Projects: 9 results
    # of Collaborated Products: 0 results
  • 3.  KAWAHARA Ysuhiro (80169755)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 0 results
  • 4.  ISHIKAWA Yuichi (90159707)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 0 results
  • 5.  INOUE Nobutaka (10304099)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  SUEMATU Masakuni (90240853)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 7.  AKITA Hozuka (60175792)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  HIRATA Ken-ichi (20283880)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  三輪 陽一
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  EMOTO Noriaki (30294218)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  松田 祐一
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 12.  岩橋 正典
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results

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