TAKAKURA Kenji 高倉賢二

Researcher Number	10221350
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2008: Kyoto University, 医学研究科, 非常勤講師 2007: Kyoto University, 医学研究科, 准教授 2001 – 2006: 京都大学, 医学研究科, 助教授 1996 – 1999: 滋賀医科大学, 医学部, 助教授 1990 – 1994: 京都大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology Except Principal Investigator Obstetrics and gynecology / Obstetrics and gynecology
Keywords	Principal Investigator 着床 / 脱落膜化 / 子宮内膜間質細胞 / FSH / 早発卵巣不全 / 胚 / 多嚢胞卵巣症候群 / 排卵障害 / 子宮内膜 / Decidualization … More / Embryo / Endometrial Epithelial Cells / Endometrial Stromal Cells / Implantation / 遺伝子発現 / 子宮内膜上皮細胞 / follicle / ovulation induction / inhibin / premature ovarian failure / 免疫異常 / 卵胞 / 排卵誘発 / インヒビン / PD-L1 / 婦人科悪性腫瘍 / 免疫回避機構 / NK細胞 / BMP / 免疫逃避機構 / 制御性T細胞 / PD-1 / 腫瘍免疫 / 婦人科腫瘍 / BDNF / ヒスタミン / 肥満細胞 / 遺伝子診断 / 抗卵胞細胞自己抗体 / 高脂血症 / 骨粗鬆症 / 自己抗体 / 早発閉経 / 胎盤 / 初期胚 / 卵 / proto-oncogene / c-Kit … More Except Principal Investigator p53 / ストレス / mouse / マウス / decidualization / LIF / M-CSF / 脱落膜化 / 不死化 / モノクロ-ナル抗体 / インタ-ロイキン1 / infertility / stress / implantation / 不妊症 / 着床 / microarray / gray zone / re-perfusion / oxidative stress / uterine smooth muscle tumor / タイプIIIコラーゲン / アポトーシス / TGF-β / 性ステロイド受容体 / Acrogranin / 細胞株 / 子宮肉腫 / 子宮筋腫 / MRI / アクログラニン / 肥満細胞 / 子宮収縮 / 月経 / 子宮平滑筋腫瘍 / マイクロアレイ / 虚血再還流 / 酸化ストレス / グレーゾーン / 子宮平滑筋腫 / co-culture of embryo and endometrial stromal cells / endometrial stromal cells / マウス胚 / 脱落膜細胞 / 胚共培養と子宮内膜間質細胞 / 胚共培養と子宮内脱間質細胞 / 子宮内膜間質細胞 / reproductive endocrinology / cell differentiation / ovarian cells / local regulation system / 生殖内分泌学 / 細胞分化 / 卵巣細胞 / 局所調節機構 / peptidase antigens / androgen / progesterone / prolactin secretion / human endometrium / ペプチダ-ゼ抗原 / MーCSF / ペプチダーゼ阻害剤 / ペプチダーゼ抗原 / アンドロゲン / プロゲステロン / プロラクチン分泌 / ヒト子宮内膜 / helper T細胞 / LAK細胞 / NK / IL-2 / 末梢血単核球 / CD25^+CD4^+T細胞 / 制御性T細胞 / エフェクターT細胞 / モノクローナル抗体 / 腫瘍免疫 / 免疫抑制 / GITR / 婦人科癌 / 免疫療法 / CD25^+CD4^+制御性T細胞 / 癌化細胞株 / 不死化細胞株 / 卵巣表層上皮細胞 / c-erbB-2 / mutant Ha-ras / hTERT / 上皮性卵巣癌 / エンドセリン / ILー1 / cDNA / プロゲステロン・リセプタ- / 増殖と分化 / 卵巣顆粒膜細胞 / インタ-ロイキン2レセプタ-@p55 / フロ-サイトメトリ- / p55 / インタ-ロイキン2レセプタ- / 卵胞顆粒膜細胞 / 卵胞発育 Less

The establishment and clinical application of new immunotherapy for gynecologic cancers by using the activation of self-tolerancePrincipal Investigator
- Principal Investigator
  
  TAKAKURA Kenji, 藤井信吾
- Project Period (FY)
  2006 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
着床期マウス子宮内膜に分布する肥満細胞の機能に関する検討Principal Investigator
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  2005
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Analyses of the influence of maternal stress on the implantation of mouse embryo
- Principal Investigator
  
  HIGUCHI Toshihiro
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
難治性婦人科悪性腫瘍に対する新しい免疫療法の開発を目指して
- Principal Investigator
  
  刈谷方俊
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Development of therapeutic and prophylactic method for the uterine smooth muscle tumors bu understanding novel aspect of its etiology
- Principal Investigator
  
  FUJII Shingo
- Project Period (FY)
  2003 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University, Graduate School of Medicine
卵巣表層上皮をもちいた上皮性卵巣癌発生過程に関与する因子の同定・解析
- Principal Investigator
  
  FUJII Shingo
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Study on Molecular Mechanism of Implantation :based on the Concept of Crosstalk between Embryo and EndometriumPrincipal Investigator
- Principal Investigator
  
  TAKAKURA Kenji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
遺伝子異常からみた排卵障害の新しい概念の構築Principal Investigator
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Prediction of the presence of follicles and development of individualized therapy in premature ovarian failure based on clinical and basic studiesPrincipal Investigator
- Principal Investigator
  
  TAKAKURA Kenji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shiga University of Medical Science
Study of the embryo-derived factors in endometrial stromal cells
- Principal Investigator
  
  NODA Yoichi
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shiga University of Medical Science
異種初期胚・子宮内膜脱落膜細胞共培養系を用いた胚受容機構の研究Principal Investigator
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  1996 – 1997
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Shiga University of Medical Science
排卵障害の免疫・内分泌学的検討及びその発症における抗卵巣自己抗体の意義の解析Principal Investigator
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Endocrinological and immunological study for local regulation of ovarian function
- Principal Investigator
  
  MORI Takahide
- Project Period (FY)
  1993 – 1994
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
C-Kitおよびそのリガンドによる卵成熟・子宮内膜・胎盤の分化調節機構の解析Principal Investigator
- Principal Investigator
  
  高倉賢二
- Project Period (FY)
  1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
Endocrinological and immunological study on regulatory mechanism of human endometrial differentiation
- Principal Investigator
  
  KANZAKI Hideharu
- Project Period (FY)
  1991 – 1992
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  KYOTO UNIVERSITY
卵巣顆粒膜細胞における増殖と分化の調節蛋白の解明
- Principal Investigator
  
  泰井俊造
- Project Period (FY)
  1990 – 1991
- Research Category
  
  Grant-in-Aid for General Scientific Research (B)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University
卵胞の発育・分化に関与する新しい卵胞内因子の同定とその生理作用に関する基礎的研究
- Principal Investigator
  
  MORI Takahide
- Project Period (FY)
  1989 – 1990
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Obstetrics and gynecology
- Research Institution
  Kyoto University

All 2009 2008 2007 2006 2005

All Journal Article Presentation

[Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer2009
- Author(s)
  Li K, Mandai M, Hamanishi J, Kenji Takakura et.al.
- Journal Title
  
  Cancer Immunol Immunother 58
  
  Pages: 649-649
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression2009
- Author(s)
  Liu M, Matsumura N, Mandai M, Kenji Takakura et.al.
- Journal Title
  
  Modern Pathology 22
  
  Pages: 373-378
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Immunostimulatory effect of Fms-like tyrosine kinase 3 ligand on peripheral monocyte-derived dendritic cells2008
- Author(s)
  Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN, Fujii S.
- Journal Title
  
  Oncol Rep. 19
  
  Pages: 19-19
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Programmed cell death 1 ligand 1 and tumor-infiltrating CD8+ T lymphocytes are prognostic factors of human ovarian cancer2007
- Author(s)
  Hamanishi J, Mandai M, Iwasaki M, Okazaki T, Tanaka Y, Yamaguchi K, Higuchi T, Yagi H, Takakura K, Minato N, Honjo T, Fujii S
- Journal Title
  
  Proc Natl Acad Sci USA 104(9)
  
  Pages: 3360-5
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.2007
- Author(s)
  Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN, Fujii S.
- Journal Title
  
  Biochem Biophys Res Commun. 360
  
  Pages: 363-9
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition.2007
- Author(s)
  Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E, Miyanishi M, Fukuhara K, Takakura K, Fujii S
- Journal Title
  
  Gynecol Oncol 105
  
  Pages: 703-11
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Immortalized ovarian surface epithelial cells acquire tumorigenicity by Acrogranin gene overexpression.2007
- Author(s)
  Miyanishi M, Mandai M, Matsumura N, (3), Takakura K, Fujii S.
- Journal Title
  
  Oncol Rep. 17(2)
  
  Pages: 329-333
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] Oncogenic property of acrogranin in human uterine leiomyosarcoma : direct evidence of genetic contribution in in vivo tumorigenesis.2006
- Author(s)
  Matsumura N, Mandai M, Miyanishi M, (4), Takakura K, Fujii S.
- Journal Title
  
  Clin Cancer Res. 12(5)
  
  Pages: 1402-1411
- Data Source
  KAKENHI-PROJECT-18209052
[Journal Article] In vivo anti-tumor effect of dual release of cisplatin and adriamycin from biodegradable gelatin hydrogel.2005
- Author(s)
  Konishi M, Takakura K, Fujii S, et al.
- Journal Title
  
  J Control Release 103・1
  
  Pages: 7-19
- Data Source
  KAKENHI-PROJECT-17659514
[Presentation] Activated local immunity by chemokine CCL19-transduced embryonic endothelial progenitor cells suppresses lung metastasis of murine ovarian cancer2009
- Author(s)
  Hamanishi J, Mandai M, Higuchi T, Yamaguchi K, Takakura K, Fujii S, Konishi I
- Organizer
  40th Annual Meeting of Women's Cancer
- Place of Presentation
  San Antonio, Texas
- Year and Date
  2009-02-06
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌腹膜播種の新生血管を標的として、ケモカイン遺伝子(CCL19)導入胚性血管内皮前駆細胞を用いて局所免疫賦活を目指した新規免疫療法開発の基礎的検討2009
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、山口建高倉賢二、藤井信吾、小西郁生
- Organizer
  第61回日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2009-04-05
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] Activated local immunity by CCL19- transduced endothelial progenitor cells suppresses lung metastasis2008
- Author(s)
  Hamanishi J, Mandai M, Higuchi T, Yamaguchi K, Takakura K, Fujii S, Konishi I
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌の新生血管を標的としてケモカイン遺伝子(CCL19)導入血管内皮前駆細胞を用いた局所免疫賦活療法2008
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾、小西郁生
- Organizer
  第44回日本婦人科腫瘍学会学術講演会
- Place of Presentation
  名古屋
- Year and Date
  2008-07-19
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌におけるNK細胞活性化受容体のリガンド発現とその意義2008
- Author(s)
  濱西潤三、李奎、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
- Organizer
  第60回日本産科婦人科学会学術講演会
- Place of Presentation
  横浜
- Year and Date
  2008-04-13
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌の新生血管での局所免疫賦活を目指した胚性血管内皮前駆細胞によるターゲティング療法2007
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
- Organizer
  第12回生殖医療フォーラム
- Place of Presentation
  奈良
- Year and Date
  2007-06-13
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌の新生血管での局所免疫賦活を目指した胚性血管内皮前駆細胞によるターゲティング療法2007
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
- Organizer
  第59回日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 免疫抑制性補助シグナル分子PD-L1発現は卵巣癌の予後と相関する2007
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、山口建、高倉賢二、藤井信吾
- Organizer
  第59回日本産科婦人科学会学術講演会
- Place of Presentation
  京都
- Year and Date
  2007-04-17
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 卵巣癌における免疫抑制性補助シグナル分子PD-L1発現と予後との相関2006
- Author(s)
  濱西潤三、万代昌紀、樋口壽宏、刈谷方俊、高倉賢二、藤井信吾
- Organizer
  第40回日本婦人科腫瘍学会学術講演会シンポジウム
- Place of Presentation
  岐阜
- Year and Date
  2006-07-21
- Data Source
  KAKENHI-PROJECT-18209052
[Presentation] 婦人科癌再発症例に対する拡大手術の試み~難治性子宮頚癌再発症例に対する骨盤半截術の経験~2006
- Author(s)
  濱西潤三、樋口壽宏、福原健、由良茂夫、万代昌紀、刈谷方俊、高倉賢二、藤井信吾
- Organizer
  第58回日本産科婦人科学会学術講演会
- Place of Presentation
  横浜
- Year and Date
  2006-04-25
- Data Source
  KAKENHI-PROJECT-18209052

1. FUJII Shingo (30135579)

# of Collaborated Projects: 6 results

# of Collaborated Products: 17 results
2. KARIYA Masatoshi (90243013)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
3. HIGUCHI Toshihiro (00283614)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. MORI Takahide (90026865)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. MAEDA Michiyuki (20027329)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. NODA Yoichi (50115911)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
7. TAKEBAYASHI Koichi (20303779)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. OKAZAKI Taku (00362468)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. MANDAI Masaki (80283597)

# of Collaborated Projects: 1 results

# of Collaborated Products: 18 results
10. YAGI Haruhiko (70402857)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
11. SAKAGUCHI Shimon (30280770)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. KANZAKI Hideharu (80135566)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. FUKUOKA Masatsune (80243012)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. KIMURA Toshio (40273411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. HIROSE Masaya (50238408)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. YURA Shigeo (60335289)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. FUJITA Jun (50173430)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. TOGASHI Kaori (90135484)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. NIKAIDO Toshio (50180568)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. FUKUHARA Ken (00362533)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 泰井俊造 (60144367)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. 藤原浩 (30252456)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. 山出一郎 (40252390)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 喜多伸幸 (20273419)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

TAKAKURA Kenji 高倉 賢二

Research Projects

Research Products

Co-Researchers

The establishment and clinical application of new immunotherapy for gynecologic cancers by using the activation of self-tolerancePrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

着床期マウス子宮内膜に分布する肥満細胞の機能に関する検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study on Molecular Mechanism of Implantation :based on the Concept of Crosstalk between Embryo and EndometriumPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

遺伝子異常からみた排卵障害の新しい概念の構築Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Prediction of the presence of follicles and development of individualized therapy in premature ovarian failure based on clinical and basic studiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

異種初期胚・子宮内膜脱落膜細胞共培養系を用いた胚受容機構の研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

排卵障害の免疫・内分泌学的検討及びその発症における抗卵巣自己抗体の意義の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

C-Kitおよびそのリガンドによる卵成熟・子宮内膜・胎盤の分化調節機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

TAKAKURA Kenji 高倉賢二