SAGARA Junji 相良淳二

… Alternative Names

SAGARA Juniji 相良淳二

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Researcher Number	10225831
Other IDs
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Affiliation (based on the past Project Information) *help	2011: 信州大学, 医学部, 教授 2007 – 2009: 信州大学, 医学部, 教授 2005: Shinshu University, School of Health Science, Professor, 医学部, 教授 2004: 信州大学, 大学院・医学研究科, 助教授 2000 – 2002: 信州大学, 医学部, 助教授 1996: Shinshu Univ.School of Medicine, Associate Prof., 医学部, 助教授 1992 – 1995: 京都大学, 薬学部, 助手
Review Section/Research Field	Principal Investigator Cell biology / General medical chemistry / Virology Except Principal Investigator Biological Sciences / Virology / Dermatology / Orthopaedic surgery / Experimental pathology
Keywords	Principal Investigator phactr / scapinin / PYRIN / ASC / アクチン / CD99 / CD44 / ERM / brain / transcription … More / nuclear structure / cell adhesion / protein phosphatase-1 / actin / 葉状仮足 / 転写調節 / 転写調節因子 / 白血病 / 脳 / 転写 / 核構造 / 細胞接着 / プロテインホスファターゼ-1 / innate immunity / inflammation / interleukine-18 / interleukine-1β / caspase-1 / apoptosis / CARD / pyrin / メチレーション / ガン / 細胞死 / 感染 / Toll-like receptor / Pyrin / 炎症疾患 / NF-KB / 自然免疫 / 炎症 / IL-18 / IL-1β / カスペース・1 / アポトーシス / host cell / Heat shock protein / Cytoskeleton / Pathogenicity / Virus / 狂犬病ウイルス / 膜骨格 / 感染防御 / 宿主細胞 / 熱ショック蛋白質 / 細胞骨格 / 病原性 / ウイルス … More Except Principal Investigator ASC / 炎症 / 狂犬病ウイルス / 細胞死 / カスペース1 / 癌 / アポトーシス / 神経病原性 / moesin / tumor formation / transplantation of tumor / nude mice / human melanoma / Has1,2 / Hyaluronate / 造腫瘍性 / 細胞運動性 / 遺伝子導入 / HAS / 遺伝子ASC / dormant state / HAS1あるいはHAS2発現 / 合成酵素遺伝子HAS1、HAS2 / モエシン / 腫瘍形成 / 移植実験 / 免疫不全マウス / ヒト悪性黒色腫 / HAS1,2 / ヒアルロン酸 / Fusion domain / Fusion protein / Acetylcholine recentor / Neuron-Specifi host factor / Cell fusion / Neurovirulence / Rabies virus / 神経細胞因子 / 病原性 / ウイルスの臓器特異性 / ウイルスの侵入 / アセチルコリンレセプター / ウイルスレセプター / ウイルスの病原性 / 膜融合ドメイン / 膜融合タンパク質 / アセチルコリン・レセプター / 神経特異的宿主因子 / 細胞融合能 / コラーゲン誘発関節炎 / DBAマウス / IL-18 / IL-1beta / 関節炎 / リウマチ病学 / 平滑筋細胞 / サイクリンD / ATP / メチル化 / オートファジー / エネルギー産生 / ピロリ菌 / 感染 / 自然免疫 / 腫瘍 / 1L-1β / メチレーション / 癌抑制遺伝子 / 腹膜播種の遺伝子治療 / CN遺伝子導入 / 腹膜中皮細胞 / カルポニン欠失 / カルポニン / メカミラミン / チャンネルブロッカー / エンドソーム / 膜融合能 / プロテインキナーゼ阻害剤 / KT5720 / マトリックスタンパク質 / シンドビスウイルス / 狂犬病ウイスル / 向神経性ウイルス / 神経細胞死 / VAP100 / VAP22 / ウイルス粒子内細胞成分 / CD44 / 細胞骨格系 / アクチン結合タンパク質 / ERMファミリータンパク質 Less

ASC plays a role in the IL-1beta, IL-18 pathway of the immune response to type II collagen in collagen-induced arthritis
- Principal Investigator
  
  TAKEOKA Michiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Orthopaedic surgery
- Research Institution
  Shinshu University
自然免疫制御因子ASCによるATP代謝制御とオートファジーに伴う細胞死の制御
- Principal Investigator
  
  谷口俊一郎
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
Role of ASC, which regulates inflammation and cell death, in Helicobacter pylori infection
- Principal Investigator
  
  TANIGUCHI Shun-ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  Shinshu University
細胞計画死と炎症シグナル制御に関与するASC/TMS1の発癌及び進展への関わり
- Principal Investigator
  
  谷口俊一郎
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
Association of Scapinin, a Protein Phosphatase-1-Binding Protein, with Nuclear StructurePrincipal Investigator
- Principal Investigator
  
  SAGARA Junji
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cell biology
- Research Institution
  Shinshu University
アクチン関連蛋白質カルポニン等を分子標的とした癌の腹膜播種の検討
- Principal Investigator
  
  TANIGUCHI Shun-ichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Shinshu University
Functional Study on a Novel Proapoptotic Protein of ASGPrincipal Investigator
- Principal Investigator
  
  SAGARA Junji
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General medical chemistry
- Research Institution
  SHINSHU UNIVERSITY
Hyaluronate production and the related molecules in human melanoma
- Principal Investigator
  
  TANIGUCHI Shun'ichiro
- Project Period (FY)
  2000 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Shinshu University
狂犬病ウイルスの神経病原性発現の分子機構について
- Principal Investigator
  
  河合明彦
- Project Period (FY)
  1995
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Kyoto University
Identification of cellular proteins in the virus particlesPrincipal Investigator
- Principal Investigator
  
  SAGARA Junji
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Shinshu University
  Kyoto University
向神経性ウイルスによる神経細胞死に関わるウイルス因子及び細胞因子の同定
- Principal Investigator
  
  河合明彦
- Project Period (FY)
  1994
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
ウイルス増殖における宿主細胞骨格系の関与について
- Principal Investigator
  
  KAWAI Akihiko
- Project Period (FY)
  1993
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Research Institution
  Kyoto University
Molecular Mechanism of the neurovirulence of rabies vlrus
- Principal Investigator
  
  KAWAI Akihiko
- Project Period (FY)
  1992 – 1993
- Research Category
  
  Grant-in-Aid for General Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  KYOTO UNIVERSITY

All 2009 2008 2007 2006 2005 2004

All Journal Article Presentation

[Journal Article] Splice Variant of ASC Regulates IL-β Release and Aggregates Differently from Intact ASC.2009
- Author(s)
  Matsushita K, Takeoka M, Sagara J, Itano N, Kurose Y, Nakamura A, Taniguchi S.
- Journal Title
  
  Mediators Inflamm. 2009
  
  Pages: 287387-287387
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012020
[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008
- Author(s)
  Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U
- Journal Title
  
  Circulation 17
  
  Pages: 3079-3087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. 82008
- Author(s)
  Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakavama J, Taniguchi S, Ikeda U.
- Journal Title
  
  Circulation 17
  
  Pages: 3079-3087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20012020
[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. 82008
- Author(s)
  Yajima N, Takahashi M, Morimoto H, Shiba Y, Takahashi Y, Masumoto J, Ise H, Sagara J, Nakayama J, Taniguchi S, Ikeda U.
- Journal Title
  
  Circulation. 17
  
  Pages: 3079-3087
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC2007
- Author(s)
  Taniguchi S, Sagara J
- Journal Title
  
  Semin Immunopathol 29(3)
  
  Pages: 231-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Regulatory molecules involved in inflammasome formation with special reference to a key mediator protein, ASC.2007
- Author(s)
  Taniguchi S, Sagara J.
- Journal Title
  
  Semin Immunopathol. 29(3)
  
  Pages: 231-238
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590385
[Journal Article] Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.2006
- Author(s)
  Yu JW, Taniguchi S, Sagara J, Alnemri ES. 他5名
- Journal Title
  
  Cell Death Differ. 13・2
  
  Pages: 236-249
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.2006
- Author(s)
  Yu JW, Taniguchi S, Sagara J, Alnemri ES. 他5名
- Journal Title
  
  Cell death Differ. 13・2
  
  Pages: 236-249
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization.2006
- Author(s)
  Yu JW, Wu J, Zhang Z, Datta P, Ibrahimi I, Taniguchi S, Sagara J, Fernandes-Alnemri T, Alnemri ES
- Journal Title
  
  Cell Death Differ. 13(2)
  
  Pages: 236-249
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.2005
- Author(s)
  Moriya M, Taniguchi S, Sagara J. 他3名
- Journal Title
  
  Biochemistry 44・2
  
  Pages: 575-583
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.2005
- Author(s)
  Moriya M, Taniguchi S, Wu P, Liepinsh E, Otting G, Sagara J.
- Journal Title
  
  Biochemistry. 44・2
  
  Pages: 575-583
- Data Source
  KAKENHI-PROJECT-16021218
[Journal Article] ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.2005
- Author(s)
  Yamamoto M, Sagara J, Taniguchi S. 他9名
- Journal Title
  
  Gene Cells 9・11
  
  Pages: 1055-1067
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] 新規アポトーシス制御蛋白ASC : インターロイキン変換酵素の新しい活性化経路2005
- Author(s)
  相良淳二
- Journal Title
  
  臨床免疫 42・3
  
  Pages: 306-312
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma.2005
- Author(s)
  Kobayashi H, Sagara J, Taniguchi S. 他4名
- Journal Title
  
  Oral Oncol 41・1
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Role of charged and hydrophobic residues in the oligomerization of PYRIN domain of ASC2005
- Author(s)
  Moriya M, Taniguchi S, Wu P, Liepnish E, Otting G, Sagara J
- Journal Title
  
  Biochemistry 44・2
  
  Pages: 575-583
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma.2005
- Author(s)
  Kobayashi H, Sagara J, Taniguchi S. 他4名
- Journal Title
  
  Oral Oncl. 41・1
  
  Pages: 38-47
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Dihydropyrimidine dehydrogenase expression predicts survival outcome and chemosensitivity to 5-fluorouracil in patients with oral squamous cell carcinoma.2005
- Author(s)
  Kobayashi H, Koike T, Nakatsuka A, Kurita H, Sagara J, Taniguchi S, Kurashina K
- Journal Title
  
  Oral Oncol. 41(1)
  
  Pages: 38-47
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC.2005
- Author(s)
  Moriya M, Taniguchi S, Wu P, Liepinsh E, Otting G, Sagara J
- Journal Title
  
  Biochemistry 44(2)
  
  Pages: 575-583
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] A proapototic protein ASC : a novel signal pathway for interleukin converting enzyme activation.2005
- Author(s)
  Sagara J, Taniguchi S
- Journal Title
  
  Chin.Immunol. 42(3)
  
  Pages: 306-312
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC is essential for LPS-induced activation of procaspase-1 independently Of TLR-associated signal adaptor molecule2004
- Author(s)
  Yamamoto M, Yanaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, et al.
- Journal Title
  
  Genes Cell 9・11
  
  Pages: 1055-1067
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.2004
- Author(s)
  Ohtsuka T, Macip S, Sagara J, Lee SW. 他4名
- Journal Title
  
  Nature Cell Biol. 6・2
  
  Pages: 121-128
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC is a Bax adaptor and regulated the p53-Bax mitochondrial apoptosis pathway2004
- Author(s)
  Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, et al.
- Journal Title
  
  Nature Cell Biol. 6・2
  
  Pages: 121-128
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASCとPYRINファミリー;新しいインターロイキン変換酵素活性化経路2004
- Author(s)
  相良淳二, 谷口俊一郎
- Journal Title
  
  信州医学雑誌 52・5
  
  Pages: 305-312
- NAID
  130005416228
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Clinical significance of cellular distribution of moesin in parients with oral squamous cell carcinoma.2004
- Author(s)
  Kobayasi H, Sagara J, Kurita H, Morifuji M, Ohishi M, Kurashina K, Taniguchi S
- Journal Title
  
  Clin. Cancer Res. 10(2)
  
  Pages: 572-580
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC is essential for LPS-induced activation of procaspase-1 independently of TLR-associated signal adaptor molecules.2004
- Author(s)
  Yamamoto M, Yaginuma K, Tsutsui H, Sagara J, Guan X, Seki E, Yasuda K, Yamamoto M, Akira S, Nakanishi K, Noda T, Taniguchi S
- Journal Title
  
  Genes Cells 9(11)
  
  Pages: 1055-1067
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] Clinical significance of cellular distribution of moesin in parients with oral squamous cell carcinoma.2004
- Author(s)
  Kobayashi H, Sagara J, Kurashina K, Taniguchi S. 他4名
- Journal Title
  
  Clin. Cancer Res. 10・2
  
  Pages: 572-580
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway.2004
- Author(s)
  Ohtsuka T, Ryu H, Minamishima YA, Macip S, Sagara J, Nakayama KI, Aaronson SA, Lee SW
- Journal Title
  
  Nat. Cell Biol. 6(2)
  
  Pages: 121-128
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] ASC and PYRIN family ; a novel signal pathway for interleukin converting enzyme activation.2004
- Author(s)
  Sagara J
- Journal Title
  
  Shinshu Medical Journal 52(5)
  
  Pages: 305-312
- NAID
  130005416228
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-16570156
[Journal Article] 新規アポトーシス制御蛋白ASC:インターロイキン変換酵素の新しい活性化経路2004
- Author(s)
  相良淳二, 谷口俊一郎
- Journal Title
  
  臨床免疫 42・3
  
  Pages: 306-312
- Data Source
  KAKENHI-PROJECT-16021218
[Journal Article] Clinical significant of cellular distribution of moesin in patients with oral squamous carcinama2004
- Author(s)
  Kobayashi H, Sagara J, Kurita H, Morifugi M, Ohishi M, et al.
- Journal Title
  
  Clin.Cancer Res. 10・2
  
  Pages: 572-580
- Data Source
  KAKENHI-PROJECT-16570156
[Presentation] Apoptosis-associated speck-like protein(ASC) promotes cell death through induction of cvclin D12008
- Author(s)
  高橋康子、高橋将文、板野直樹、相良淳二、谷口俊一郎
- Organizer
  第67回日本癌学会学術総会
- Place of Presentation
  名古屋
- Year and Date
  2008-10-28
- Data Source
  KAKENHI-PROJECT-20012020
[Presentation] ASC deficiency enhances autophagy for cell survival.2007
- Author(s)
  Takahashi Y, Takahashi M, Itano N, Sagara J, Taniguchi S.
- Organizer
  66th Annual Meeting of the Japanese Cancer Association
- Place of Presentation
  Yokohama
- Data Source
  KAKENHI-PROJECT-19590385
[Presentation] カスペース-1活性化シグナル経路のアダプター分子ASCスプライシング変異体(vASC)の機能解析2007
- Author(s)
  松下一彦、相良淳二、谷口俊一郎
- Organizer
  第37回日本免疫学会総会・学術集会
- Place of Presentation
  東京
- Data Source
  KAKENHI-PROJECT-19590385

1. TANIGUCHI Shun-ichiro (60117166)

# of Collaborated Projects: 8 results

# of Collaborated Products: 26 results
2. KAWAI Akihiko (70027332)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. MORIMOTO Kinjiro (80183664)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
4. TAKEOKA Michiko (30197280)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TSUTSUI Hiroko (40236914)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. KOBAYASHI Motohiro (00362137)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. ITANO Naoki (40257712)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
8. EHARA Takashi (00203646)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. KATO Hiroyuki (40204490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. SAIDA Toshiaki (10010381)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 中山淳 (10221459)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. YAMAZAKI Hideshi

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

SAGARA Junji 相良 淳二

SAGARA Juniji 相良 淳二

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Association of Scapinin, a Protein Phosphatase-1-Binding Protein, with Nuclear StructurePrincipal Investigator

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Functional Study on a Novel Proapoptotic Protein of ASGPrincipal Investigator

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Identification of cellular proteins in the virus particlesPrincipal Investigator

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[Journal Article] Splice Variant of ASC Regulates IL-β Release and Aggregates Differently from Intact ASC.2009

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[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice2008

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Journal Title

Data Source

[Journal Article] Critical role of bone marrow apoptosis-associated speck-like protein, an inflammasome adaptor molecule, in neointimal formation after vascular injury in mice. 82008

SAGARA Junji 相良淳二

SAGARA Juniji 相良淳二