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KOYAMA Hiroyuki  小山 博之

ORCIDConnect your ORCID iD *help
… Alternative Names

小山 博之  コヤマ ヒロユキ

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Researcher Number 10241994
External Links
Affiliation (based on the past Project Information) *help 2016 – 2018: 東京大学, 医学部附属病院, 登録研究員
2015: 東京大学, 医学部附属病院, 特任准教授
2014 – 2015: 東京大学, 医学部附属病院, 准教授
2007 – 2013: The University of Tokyo, Hospital, Project Associate Professor
2009: 東京大学, 医学部附属病院, 客員准教授 … More
2007 – 2009: The University of Tokyo, Faculty of medicine, Specially appointed associate professor
2008: The University of Tokyo, 医学部付属病院, 特任准教授
2007: The University of Tokyo, 医学部付属病院, 寄付講座教員
2007: 東京大学, 医学部附属病院, 寄付講座教員
2006 – 2007: 東京大学, 医学部附属病院, 客員准教授
2006: 東京大学, 医学部附属病院, 寄付講座教員(客員准教授)
2005: The University of Tokyo, Faculty of Medicine, Visiting Associate Professor, 医学部附属病院, 寄附講座教員
2003 – 2005: The University of Tokyo, Faculty of Medicine, visiting Associate Professor, 医学部附属病院, 客員助教授
2004: 東京大学, 医学部附属病院, 寄付講座教員
2003: 医学部附属病院, 助教授
2003: 東京大学, 医学部附属病院, 客員助教授(常勤形態)
2002 – 2003: THE UNIVERSITY OF TOKYO, The University of Tokyo, Faculty of Medicine, Associate prof
1999 – 2001: The Univ. of Tokyo, Hospital, Instructor, 医学部・附属病院, 助手
1994: 東京大学, 医学部(病), 助手 Less
Review Section/Research Field
Principal Investigator
General surgery / Cardiovascular surgery / General surgery / Surgical dentistry
Except Principal Investigator
General surgery / General surgery / Plastic surgery / Cardiovascular surgery / Surgical dentistry
Keywords
Principal Investigator
血管新生 / RGD / bFGF / Reverse transfection / 内膜肥厚 / TRAF / 再生医学 / 塩基性線維芽細胞増殖因子 / ドラッグデリバリー / 急性下肢虚血 … More / 血管再生医療 / PICsome / 虚血肢モデル / ナノ粒子 / ischemia / Nano-micelle / Therapeutic angiogenesis / Rabbit carotid artery / Intimal Hyperplasia / Polymer nano-micellsb / Acidic gelatin hydrogel / 高分子ミセル型ナノ・パーティクル / 血管新生療法 / TRAF6 / 治療的血管新生 / Artery wall binding peptide / RGDペプチド / 高分子ミセル型ナノパーティクル / コーティング / 高分子ミセル型ナノパーティク / 治療的血管新生療法 / ウサギ頚動脈 / 高分子ミセル型ナノパーテ / 酸性ゼラチンハイドロゲル / smooth muscle cell / intimal hyperplasia / inflammation / rabbit / reinjury / stent / Protein kinase C / Protein kinase B / 再障害モデル / ラビット / 血管内ステント / p70^<S6k> / Pootion kinase C / Phosphatidylinositol-3-kinase / 平滑筋細胞 / 炎症 / ウサギ / 再障害 / ステント / 細胞・組織 / 外科 / 人工臓器 / ハイドロゲル / 生体材料 / 大型化 / 三次元再生組織 / 足場材料 / 膵島移植 / スフェロイド / 栄養血管 / 再生組織 / 人工臓器学 / 再生骨 / スカフォール / トマテリアル / スカフォールド / マテリアル / 口腔外外科一般 … More
Except Principal Investigator
bFGF / 血管新生療法 / electroporation / 内膜肥厚 / 遺伝子治療 / 血管外科学 / ナノ材料 / RGD / Reverse transfection / Recipient bed / In vivo electroporation / Axial skin flap / 高分子ナノミセル構造体 / 遺伝子導入 / plasmid DNA / Electroporation / TRAF6 / ラビット / Ex vivo / Ephrin B2 / VEGF / Gene therapy / p27 / endothelial cell / 血管内皮細胞 / thrombomodulin / tissue plasminogen activator / adenovirus / 塩基性線維芽細胞増殖因子 / 小口径人工血管 / 血管新生 / ステント留置後再狭窄 / TRAF / バルーン障害モデル / 超分子 / 超分子化学 / platelet-activating factor / osteoclast / bone destruction / lipid mediator / 骨破壊病変遺伝子治療 / 非病原性ベクター / 血小板活性化因子 / 破骨細胞 / 骨破壊性病変 / 脂質メディエータ / Circulation, Hypertension / Surgery / Nano-material / 循環器・高血圧 / 外科 / Vascular tissue / Gene delivery / Bone regeneration / collagen gel / Polymer nano-micellsb / Reverse transfect / Artery wall binding peptide / RGDペプチド / 血管組織 / 再生骨 / コラーゲンゲル / Polymer micelle / Micropheres / Acidic gelatin hydrogel / 高分子ミセル型ナノ・パーティクル / Skin flap / Recipient b / マイクロスフィアー / 酸性ゼラチンハイドロゲル / signal pathway / smooth muscle cell / intival hyperplasia / 静脈置換モデル / 細胞内signal伝達機構 / 血管平滑筋細胞 / gene transfer / In-stent restenosis / Inflammatory signaling pathway / Intimal hyperplasia / Balloon injury model / 再狭窄 / バルーン障害 / 再障害 / ジーンチップ / ステント / 再障害モデル / 炎症シグナル伝達 / Rabbit / Angiogenic therapy / 虚血肢 / ラテンウイエルス / Ephrine B2 / Therapeutic angiogenesis / ポリエチレンイミン / ウサギ / CD40リガンド / Eph B4 / Ex vivo法 / ウサギ下肢虚血モデル / Rb protein / Cyclin D / neointimal hyperplasia / Rat carotid balloon injury / Adenovirus / p21 / Rb蛋白 / サイクリンD / ラット頚動脈バルーン障害 / アデノウイルス / small caliber vascular prosthesis / hybrid-type vascular prosthesis / gene therapy / vetrovirus / retrovirus / ハイブリッド型人工血管 / IL-1β / マウス重症虚血肢モデル / ドラッグデリバリーシステム / 側副血管 / 重症虚血肢 / ナノメディシン / ドラッグデリバリー / 急性下肢虚血 / 血管外科 / 人工血管 / ラビット虚血肢モデル / 側副血行路 / 再生医療 / 抗血栓性 / MPCポリマー / RNA干渉 / 血管再生 / 低酸素誘導因子 / 乳癌抑制遺伝子 / 低酸素応答因子 / 血管外外科一般 / GPCR受容体 / オーファン受容体 / 脂質リガンド / 骨吸収性疾患 / コラーゲン線維束 / 腹部大動脈 / コラーゲン線維 / 加齢変化 / 腹部大動脈瘤 / レボビスト / 無侵襲治療 / 下肢静脈瘤 / HIFU / 炎症性シグナル伝達 Less
  • Research Projects

    (26 results)
  • Research Products

    (128 results)
  • Co-Researchers

    (52 People)
  •  Development of novel supramolecular drug for the treatments of neointimal lesions and aortic aneurysm

    • Principal Investigator
      Miura Yutaka
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      The University of Tokyo
  •  New treatment strategy for acute lower limb ischemia by using nano-micellPrincipal Investigator

    • Principal Investigator
      KOYAMA HIROYUKI
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      The University of Tokyo
  •  Novel approach to acute limb ischemia with nano-DDS

    • Principal Investigator
      Nishiyama Ayako
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular surgery
    • Research Institution
      The University of Tokyo
  •  Increasing in size of 3-dimentional regenerative tissue by intra-structural perfusion system.Principal Investigator

    • Principal Investigator
      KOYAMA Hiroyuki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Construction of vascular network in regenerative tissue by using angiogenic materials.Principal Investigator

    • Principal Investigator
      KOYAMA Hiroyuki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Molecular pathological analyses of collateral augmentation for a development of novel angiogenic therapy

    • Principal Investigator
      MIYATA Tetsurou
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Experimental evaluation of a silk fibroin-coated vascular prosthesis

    • Principal Investigator
      SHIGEMATSU Kunihiro
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Development of small-diameter vascular graft composed of antithrombogenic phospholipid polymer

    • Principal Investigator
      OKAMOTO Hiroyuki
    • Project Period (FY)
      2009 – 2011
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Development of therapy targeting orphan GPCR-related lipid mediators for prevention of bone destruction

    • Principal Investigator
      HIKIJI Hisako
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      Kyushu Dental College
  •  Silencing of Int6 Promotes Recovery of Blood Perfusion after Limb Ischemia via Stabilizing Hypoxia-Inducible Factor 2α

    • Principal Investigator
      KIMURA Hideo
    • Project Period (FY)
      2008 – 2010
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Development of novel living material by regulation of angiogenesisPrincipal Investigator

    • Principal Investigator
      KOYAMA Hiroyuki
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokyo
  •  Development of a less invasive treatment for varicose veins with high intensity focused ultrasound

    • Principal Investigator
      MIYATA Tetsuro, 西蔭 誠二
    • Project Period (FY)
      2007 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Structural analysis of collagen fiber of arterial wall in patients with abdominal aortic aneurysm

    • Principal Investigator
      SHIGEMATSU Kunihiro, 出口 順夫
    • Project Period (FY)
      2006 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  炎症性シグナルの制御による新しいステント内再狭窄発生予防の開発

    • Principal Investigator
      石井 誠之
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Gene delivery using polyion complex micelle for the treatment of aortic aneurysm

    • Principal Investigator
      MIYATA Tetsuro
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Gene therapy targeting lipid mediators for prevention of bone destruction

    • Principal Investigator
      HIKIJI Hisako
    • Project Period (FY)
      2005 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Surgical dentistry
    • Research Institution
      The University of Tokyo
  •  Novel tissue regeneration using polymer nano-micelle gene delivery system

    • Principal Investigator
      TAKATO Tsuyoshi
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Plastic surgery
    • Research Institution
      The University of Tokyo
  •  New support system of vascular surgery using novel bio-materialsPrincipal Investigator

    • Principal Investigator
      KOYAMA Hiroyuki
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Non-invasive soft tissue reconstruction using therapeutic angiogenesis.

    • Principal Investigator
      EGUCHI Tomoaki
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Plastic surgery
    • Research Institution
      The University of Tokyo
  •  Development of gene transfer by in vivo electroporation to the vascular wall

    • Principal Investigator
      MIYATA Tetsuro
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Neointimal formation in the earotid artery of in IP3^R knock out mouse

    • Principal Investigator
      NAKAZAWA Tatsu
    • Project Period (FY)
      2002 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Novel angiogenic gene therapy for the treatment of ischemic limb

    • Principal Investigator
      MIYATA Tetsuro
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  The pathophysiological study of mechanisms which contribute to in-stent restenosis

    • Principal Investigator
      SHIGEMATSU Hiroshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  Signal transduction regulating intimal cell replication in arterial lesionPrincipal Investigator

    • Principal Investigator
      KOYAMA Hiroyuki
    • Project Period (FY)
      2000 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  Gene therapy for anastomotic stenosis after arterial reconstruction

    • Principal Investigator
      OSHIRO Hidemi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      The University of Tokyo
  •  APPLICATION OF GENETRANSFER TECHNIQUE TO ENDOTHELIAL CELL SEEDED VASCULAR PROSTHESIS

    • Principal Investigator
      MIYATA Tetsuro
    • Project Period (FY)
      1994 – 1996
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      General surgery
    • Research Institution
      UNIVERSITY OF TOKYO

All 2018 2016 2015 2014 2013 2012 2011 2010 2009 2008 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Patent Other

  • [Journal Article] Targeting ability of self-assembled nanomedicines in rat acute limb ischemia model is affected by size2018

    • Author(s)
      Suhara Masamitsu、Miura Yutaka、Cabral Horacio、Akagi Daisuke、Anraku Yasutaka、Kishimura Akihiro、Sano Masaya、Miyazaki Takuya、Nakamura Noriko、Nishiyama Ayako、Kataoka Kazunori、Koyama Hiroyuki、Hoshina Katsuyuki
    • Journal Title

      Journal of Controlled Release

      Volume: 286 Pages: 394-401

    • DOI

      10.1016/j.jconrel.2018.07.049

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K10748, KAKENHI-PROJECT-16H03179, KAKENHI-PROJECT-16H05422, KAKENHI-PROJECT-17H04742, KAKENHI-PROJECT-16K10652
  • [Journal Article] Adequately-sized nanocarriers allow sustained targeted drug delivery to neointimal lesions in rat arteries2016

    • Author(s)
      R. Taniguchi, Y. Miura, H. Koyama, T. Chida, Y. Anraku, A. Kishimura, K. Shigematsu, K. Kataoka, T. Watanabe
    • Journal Title

      Molecular Pharmaceutics

      Volume: 13 Issue: 6 Pages: 2108-2116

    • DOI

      10.1021/acs.molpharmaceut.6b00219

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-16H05422
  • [Journal Article] Nanoparticles effectively target rapamycin delivery to sites of experimental aortic aneurysm in rats2016

    • Author(s)
      T. Shirasu, H. Koyama, Y. Miura, K. Hoshina, K. Kataoka, T. Watanabe
    • Journal Title

      PLOS ONE

      Volume: 11 Issue: 6 Pages: e0157813-e0157813

    • DOI

      10.1371/journal.pone.0157813

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-16H05422
  • [Journal Article] Silencing of eIF3e promotes blood perfusion recovery after limb ischemia through stabilization of hypoxia-inducible factor 2α activity.2015

    • Author(s)
      Hashimoto T, Chen L, Kimura H, Endler A, Koyama H, Miyata T, Shibasaki F, Watanabe T.
    • Journal Title

      J Vasc Surg.

      Volume: published online Issue: 1 Pages: 219-226.e3

    • DOI

      10.1016/j.jvs.2015.01.004

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] Therapeutic site selection is important for the successful development of collateral vessels.2015

    • Author(s)
      Nishiyama A, Koyama H, Miyata T, Watanabe T
    • Journal Title

      J Vasc Surg

      Volume: 62 Issue: 1 Pages: 190-199

    • DOI

      10.1016/j.jvs.2014.02.004

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462100, KAKENHI-PROJECT-25293273
  • [Journal Article] Adequate Selection of a Therapeutic Site Enables Efficient Development of Collateral Vessels in Angiogenic Treatment With Bone Marrow Mononuclear Cells.2015

    • Author(s)
      Nemoto M, Koyama H, Nishiyama A, Shigematsu K, Miyata T, Watanabe T.
    • Journal Title

      J Am Heart Assoc

      Volume: 4 Issue: 9

    • DOI

      10.1161/jaha.115.002287

    • Peer Reviewed / Acknowledgement Compliant / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26462100, KAKENHI-PROJECT-25293273
  • [Journal Article] Therapeutic site selection is important for the successful development of collateral vessels2015

    • Author(s)
      Ayako Nishiyama, Hiroyuki Koyama, Tetsuro Miyata, Toshiaki Watanabe
    • Journal Title

      Jounal of Vascular Surgery, In Press Corrected Proof

      Volume: 62 Pages: 190-199

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26462100
  • [Journal Article] Sugar-based crosslinker forms a stable atelocollagen hydrogel that is a favorable microenvironment for 3D cell culture2014

    • Author(s)
      Kamimura W, Koyama H, Miyata T, Takato T
    • Journal Title

      Journal of Biomedical Materials Research

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] Therapeutic site selection is important for the successful development of collateral vessels2014

    • Author(s)
      Nishiyama A, Koyama H, Miyata T, Watanabe T
    • Journal Title

      Journal of Vascular Surgery

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] Sugar-based crosslinker forms a stable atelocollagen hydrogel that is a favorable microenvironment for 3D cell culture2014

    • Author(s)
      Kamimura W, Koyama H, Miyata T, Takato T.
    • Journal Title

      J Biomed Mater Res A.

      Volume: 102 Pages: 4309-4316

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] An in vivo murine model for screening cranial bone regenerative materials: testing of a novel synthetic collagen gel2014

    • Author(s)
      Hikiji H, Tomizuka K, Taguchi T, Koyama H, Chikazu D, Mori Y, Takato T
    • Journal Title

      The Journal of Materials Science: Materials in Medicine

      Volume: 印刷中

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] Bone regeneration by the combined use of tetrapod-shaped calcium phosphate granules with basic fibroblast growth factor-binding ion complex gel in canine segmental radial defects.2014

    • Author(s)
      Honnami M, Choi S, Liu IL, Kamimura W, Taguchi T, Hojo H, Shimohata N, Ohba S, Koyama H, Nishimura R, Chung UI, Sasaki N, Mochizuki M.
    • Journal Title

      J Vet Med Sci.

      Volume: 76 Pages: 955-961

    • NAID

      130003391309

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Journal Article] Vascular-inducing poly(glycolic acid)-collagen nanocomposite-fiber scaffold2013

    • Author(s)
      H. Kobayashi, D. Terada, Y. Yokoyama, D. WonMoon, Y. Yasuda, H. Koyama, T. Takato
    • Journal Title

      Journal of Biomedical Nanotechnology

      Volume: 9 Issue: 8 Pages: 1318-1326

    • DOI

      10.1166/jbn.2013.1638

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-24300176, KAKENHI-PROJECT-25293273
  • [Journal Article] Impact of polyplex micelles installed with cyclic RGD peptide as ligand on gene delivery to vascular lesions2012

    • Author(s)
      Kagaya H, Koyama H, Miyata T
    • Journal Title

      Gene Therapy

      Volume: 19 Issue: 1 Pages: 61-69

    • DOI

      10.1038/gt.2011.74

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244, KAKENHI-PROJECT-22390245, KAKENHI-PROJECT-22800013, KAKENHI-PROJECT-23350049
  • [Journal Article] A calcium-cross-linked hydrogel based on alginate-modified atelocollagen functions as a scaffold material.2012

    • Author(s)
      Kamimura W, Koyama H, MiyataT
    • Journal Title

      Journal of biomaterials science. Polymer edition

      Volume: 23 Pages: 609-628

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Journal Article] A calcium-cross-linked hydrogel based on alginate-modified atelocollagen functions as a scaffold material2012

    • Author(s)
      Kamimura W, Koyama H, et al.
    • Journal Title

      Journal of biomaterials science. Polymer edition

      Volume: 23 Issue: 5 Pages: 609-628

    • DOI

      10.1163/092050611x555678

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244, KAKENHI-PROJECT-22390245
  • [Journal Article] Polylex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery2011

    • Author(s)
      M.Oba, K.Miyata, K.Osada, R.J.Christie, M.Sanjoh, W.Li, S.Fukushima, T.Ishii, M.R.Kano, N.Nishiyama, H.Koyama, K.Kataoka
    • Journal Title

      Biomaterials

      Volume: 32(2) Issue: 2 Pages: 652-663

    • DOI

      10.1016/j.biomaterials.2010.09.022

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20689024, KAKENHI-PROJECT-21659299, KAKENHI-PROJECT-22390244, KAKENHI-PROJECT-22750098
  • [Journal Article] A Calcium-Cross-Linked Hydrogel Based on Alginate-Modified Atelocollagen Functions as a Scaffold Material.2011

    • Author(s)
      Kamimura W, Koyama H, et al.
    • Journal Title

      Journal of biomaterials science. Polymer edition

      Volume: (In press)(掲載確定)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Journal Article] Enhanced Neovascular Formation in a Novel Hydrogel Matrix Consisting of Citric Acid and Collagen2011

    • Author(s)
      Nagayoshi M, Koyama H, Miyata T
    • Journal Title

      Ann Vasc Dis

      Volume: 4 Issue: 3 Pages: 196-203

    • DOI

      10.3400/avd.oa.11.00017

    • NAID

      130004487910

    • ISSN
      1881-641X, 1881-6428
    • Language
      English
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244, KAKENHI-PROJECT-22390245
  • [Journal Article] Improvement in wound healing by a novel synthetic collage-gel dressing in genetically diabetic mice.2010

    • Author(s)
      Chikazu D, Taguchi T, Koyama H, Hikiji1 H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T.
    • Journal Title

      Asian. J.Oral.Maxillofac. Surg. 22

      Pages: 61-67

    • Data Source
      KAKENHI-PROJECT-20390508
  • [Journal Article] Improvement in wound healing by a novel synthetic collage-gel dressing in genetically diabetic mice2010

    • Author(s)
      Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y, Seto I, Iino M, Takato T
    • Journal Title

      Asian. J. Oral. Maxillofac. Surg

      Volume: 22 Pages: 61-67

    • Data Source
      KAKENHI-PROJECT-20390508
  • [Journal Article] Polyplex micelles prepared from ω-cholesteryl PEG-polycation block copolymers for systemic gene delivery2010

    • Author(s)
      Oba M, Koyama H, et al.
    • Journal Title

      Biomaterials

      Volume: 32 Pages: 652-663

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micell es loading plasmid DNA encoding soluble flt-12010

    • Author(s)
      Oba M, Koyama H, Kataoka K, et al.
    • Journal Title

      Mol Pharm. 7 (2)

      Pages: 201-509

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble flt-12010

    • Author(s)
      Oba M, Koyama H, et al.
    • Journal Title

      Molecular pharmaceutics

      Volume: 7 Pages: 501-509

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Journal Article] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Genetically Diabetic Mice2010

    • Author(s)
      Chikazu D., Koyama H., et al
    • Journal Title

      Asian Journal of Oral and Maxillofacial Surgery (In press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Antiangiogenic gene therapy of solid tumor by systemic injection of polyplex micelles loading plasmid DNA encoding soluble Flt-12010

    • Author(s)
      M. Oba, Y. Vachutinsky, K. Miyata, M. R. Kano, S. Ikeda, N. Nishiyama, K. Itaka, K. Miyazono, H. Koyama, K. Kataoka
    • Journal Title

      Mol. Pharm

      Volume: 7(2) Issue: 2 Pages: 501-509

    • DOI

      10.1021/mp9002317

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21659299, KAKENHI-PROJECT-22390244
  • [Journal Article] The growth of a vascular net work insi de a coll agen-citric acid derivative hydrogel in rats2009

    • Author(s)
      Takayama T, Taguchi T, Koyama H, et al.
    • Journal Title

      Biomaterials 30 (21)

      Pages: 3580-3587

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Selective and sustained delivery of basic fibroblast growth factor(bFGF)for treatment of peripheral arterial disease : results of a phase I trial.2009

    • Author(s)
      Hashimoto T., Koyama H., et al
    • Journal Title

      European Journal of Vascular & Endovascular Surgery 38

      Pages: 71-75

    • NAID

      10026912168

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Environment-responsive block copolymer micelles with a disul fide cross-linked core for enhanced si RNA delivery2009

    • Author(s)
      Matsumoto S, Oba M, Koyama H, et al.
    • Journal Title

      Biomacromol ecules 10

      Pages: 119-127

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Selective and sustained delivery of basic fibrobl ast growth factor (bFGF) for treatment of peripheral arterial disease : results of a phase I trial2009

    • Author(s)
      Hashimoto T, Koyama H, Miyata T, at al.
    • Journal Title

      Eur J Vasc Endovasc Surg. 38

      Pages: 71-75

    • NAID

      10026912168

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Exvivo gene delivery of ephrin-B2 induces devel opment of functional coll ater al vessel sinarabbit model of hind limb ischemia2009

    • Author(s)
      Katsu M, Koyama H, Maekawa H, et al.
    • Journal Title

      J Vasc Surg 49

      Pages: 192-198

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] The growth of a vascular network inside a collagen-citric acid derivative hydrogel in rats2009

    • Author(s)
      Takayama T., Koyama H., et al
    • Journal Title

      Biomaterials 30

      Pages: 3580-3587

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle fiap and increased perfusion capacity via minor pedicle2008

    • Author(s)
      Yasuda Y, Koyama H, et. al.
    • Journal Title

      Journal of Surgical Research (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity viaminor pedicle2008

    • Author(s)
      Yasuda Y., Koyama H., Oba M, et al.
    • Journal Title

      Journal of Surgical Research 147 (1)

      Pages: 132-7

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle.2008

    • Author(s)
      Yasuda Y. Koyama H. Oba M. et al
    • Journal Title

      Journal of Surgical Research 147

      Pages: 5163-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle2008

    • Author(s)
      Yasuda Y, Koyama H, et. al.
    • Journal Title

      Joumal of Surgical Research (in press)

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle2008

    • Author(s)
      Yasuda Y, Koyama H, et al
    • Journal Title

      Journal of Surgical Research 147

      Pages: 132-137

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Charge-conversion ternary polyplex with endosome disruption moiety: a to chnique for efficient and safe gene delivery.2008

    • Author(s)
      Lee Y. Oba M. Koyama H. et at
    • Journal Title

      Angewandte Chemie. International Ed. In English. 47

      Pages: 5163-6

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Polyplexes from poly (aspartamide) bearing 1, 2-diaminoet hane si de chains induce pH-selective, endosomal membrane dest abilization with amplified transfection and negligible cytotoxicity2008

    • Author(s)
      Miyata K., Oba M., Koyama H, et al.
    • Journal Title

      Journal of the American Chemical Society 130 (48)

      Pages: 16287-94

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled delivery of bFGF to recipient bed enhances the vascul arization and viability of an ischemic skin flap2008

    • Author(s)
      Fujihara Y., Koyama H., Ohba M, et al
    • Journal Title

      Wound Repair & Regeneration 16 (1)

      Pages: 125-31

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Polyplex micelles from triblock copolymers composed of tandemly aligned segments with biocompatible, endosomat escaping, and DNA condensing functions for systemic gene delivery to pancreatic tumor tissue.2008

    • Author(s)
      Miyata K. Oba M. Koyama H. et al
    • Journal Title

      Pharmaceutical Research. 25

      Pages: 2924-36

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Polyplex micelles fromtri block copolymers composed of tandemly aligned segment with biocompatible, endosomal escaping, and DNA condensing functions for systemic gene delivery to pancreatic tumor tissue2008

    • Author(s)
      Miyata K., Oba M., Koyama H, et al.
    • Journal Title

      Pharmaceutical Research 25 (12)

      Pages: 2924-36

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] PEG-det achable polyplex micelles based on disulfide-linked block catiomers as bior esponsive nonviral gene vectors2008

    • Author(s)
      Takae S., Oba M., Koyama H, et al.
    • Journal Title

      Journal of the American Chemical Society 130 (18)

      Pages: 6001-9

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Controlled Delivery of bFGF to Recipient Bed Enhances Vascularization and Viability of Ischemic Skin Flap2008

    • Author(s)
      Fujiwara Y, Oba M, Koyama H, et. al.
    • Journal Title

      Wound Repair and Regeneration (in press)

    • NAID

      10031181445

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Polyplex micelles with cyclic RGD peptide ligands and disulfide cross-links directing to the enhanced transfection via controlled intracellular trafficking2008

    • Author(s)
      Oba M., Koyama H., Kataoka K, et al.
    • Journal Title

      Molecular Pharmaceutics 5 (6)

      Pages: 1080-92

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Cyclic RGD petide-conjugated polyplex micelles as a target able gene dilivery system directed to cells possessing avb3 and avb5 integrins2007

    • Author(s)
      Oba M, Koyama H, et al
    • Journal Title

      Bioconjugate Chemistry 18

      Pages: 1415-1423

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation2007

    • Author(s)
      Akagi D, Koyama H, Miyata T, et al
    • Journal Title

      Gene Therapy 14

      Pages: 1029-1038

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Study of quantitative aminolysis reaction poly(□-benzyl L-aspartate)(PBLA)as a platform polymer for functionality materials2007

    • Author(s)
      Oba M, Koyama H, et. al.
    • Journal Title

      Reactive & Functional Polymers 18

      Pages: 1361-1372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Study of quantitative aminolysis reaction poly(ロ-benzyl L-aspartate) (PBLA) as a platform polymer for functionality materials2007

    • Author(s)
      Oba M, Koyama H, et. al.
    • Journal Title

      Reactive & Functional Polymers 18

      Pages: 1361-1372

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus for mation2007

    • Author(s)
      Akagi D, KoYama H, Miyata T, et. al.
    • Journal Title

      Gene Therapy 14

      Pages: 1029-1038

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Cyclic RGD peptide-conjugated polyplex micelles as a targetable gene delivery system directed to cells possessing avb3 and avb5 integrins2007

    • Author(s)
      Oba M, Koyama H, et al
    • Journal Title

      Bioconjugate Chemistry 18

      Pages: 1415-1423

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Planter flexion as an alternative Treadmill exercise for evaluating patients with intermittent claudication2007

    • Author(s)
      Yamanoto K, Miyata T, Onozuka A, Koyama H, et al.
    • Journal Title

      Journal of Vascular and Endovascular Surgery 33

      Pages: 325-329

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Biocompatible micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxicity and thrombus formation2007

    • Author(s)
      Akagi D, Oba M, Koyama H, Miyata T, et al.
    • Journal Title

      Gene Therapy (In press)

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Biocompatible Micellar nanovectors achieve efficient gene transfer to vascular lesions without cytotoxi city and thrombus formation2007

    • Author(s)
      Akagi D, Koyama H, Miyata T, et al
    • Journal Title

      Gene Therapy 14

      Pages: 1029-1038

    • Data Source
      KAKENHI-PROJECT-19390510
  • [Journal Article] Inflammatory responses involving tumor necrosis factor receptor-associated factor 6 contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery.2006

    • Author(s)
      Miyahara T., Koyama H., Miyata T, et al.
    • Journal Title

      Journal of Vascular Surgery 43

      Pages: 592-600

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Inflammatory responses involving tumor necrosis factor receptor-associated factor & contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery2006

    • Author(s)
      Miyahara T, Koyama H, Miyata T, et al.
    • Journal Title

      Journal of Vascular Surgery 43

      Pages: 592-600

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Inflammatory responses involving tumor necrosis factor receptor-associated factor 6 contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery.2006

    • Author(s)
      Miyahara T, Koyama H, et al.
    • Journal Title

      Journal of Vascular Surgery 43

      Pages: 592-600

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Inflammatory responses involving TRAF6 contribute to in-stent lesion formation in a stent implantation model of rabbit carotid artery2006

    • Author(s)
      Miyahara T, Koyama H, Miyata T, Shigematsu H, Inoue J, Takato T, Nagawa H.
    • Journal Title

      Journal of Vascular Surgery 43(3)

      Pages: 592-600

    • Data Source
      KAKENHI-PROJECT-17591322
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap.2005

    • Author(s)
      Fujihara Y, Koyama H, Miyata T, et al.
    • Journal Title

      British Journal of Plastic Surgery 58

      Pages: 511-517

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Preparation and biological characterization of polymeric micelle drug carriers with intracellular pH-triggered drug release property : Tumor permeability, controlled subcellular drug distribution, and enhanced in vivo antitumor efficacy2005

    • Author(s)
      Bae Y, Nishiyama N, Koyama H, Kataoka K et al.
    • Journal Title

      Bioconjug.Chem. 16

      Pages: 122-130

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with poly(ethylene glycol) to enhance intracellular photodynamic efficacy.2005

    • Author(s)
      Jang WD, Nishiyama N, Koyama H, Kataoka K et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl 44

      Pages: 419-423

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Light-induced gene transfer from packaged DNA enveloped in a dendrimeric photosensitizer2005

    • Author(s)
      Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Nature Material 4

      Pages: 934-941

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap.2005

    • Author(s)
      Fujihara Y, Koyama H, et al.
    • Journal Title

      British Journal of Plastic Surgery 58

      Pages: 511-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles2005

    • Author(s)
      Cabral H, Nishiyama N, Koyama H, Kataoka K et al.
    • Journal Title

      J.Control.Release 101

      Pages: 223-232

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Supramolecular nanocarrier of anionic dendrimer prophyrins with cationic block copolymers modified with poly(ethylene glycol) to enhance intracellular photodynamic efficacy.2005

    • Author(s)
      Jang WD, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Angew. Chem. Int. Ed. Engl 44

      Pages: 419-423

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Light-induced gene transfer from packaged DNA enveloped in a dentrimeric photosensitizer2005

    • Author(s)
      Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Nature Material 4

      Pages: 934-941

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap2005

    • Author(s)
      Fujihara Y, Koyama H, et al.
    • Journal Title

      British Journal of Plastic Surgery 58

      Pages: 511-517

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Preparation and biological properties of dichloro(1,2-diaminocyclohexane)platinum(II) (DACHPt)-loaded polymeric micelles2005

    • Author(s)
      Cabral H, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      J. Control. Release 101

      Pages: 223-232

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Preparation and biological properties dichloro (1, 2-diaminocyclohexane) platinum (II) (DACHPt)-loaded polymeric micelles2005

    • Author(s)
      Cabral H, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      J.Contorol.Release 101

      Pages: 223-232

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap.2005

    • Author(s)
      Fujihara Y, Koyama H, Eguchi T, Takato T.
    • Journal Title

      British Journal of Plastic Surgery 58

      Pages: 511-517

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Supramolecular nanocarrier of anionic dendrimer porphyrins with cationic block copolymers modified with poly (ethylene glycol) to enhance intracellular photodynamic efficacy.2005

    • Author(s)
      Jang WD, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl 44

      Pages: 419-423

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Supramolecular nanocarrier of anionic dentrimer porphyrins with cationic block copolymers modified with poly(ethylene glycol) to enhance intracellular photodynamic efficacy2005

    • Author(s)
      Jang WD, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Angew.Chem.Int.Ed.Engl 44

      Pages: 419-423

    • Data Source
      KAKENHI-PROJECT-17390345
  • [Journal Article] Persistent sciatic artery in a patient with extracranial internal carotid artery aneurysm and infrarenal abdominal aortic aneurysm : A case report.2005

    • Author(s)
      Miyahara T, Miyata T, Shigematsu K, Shigematsu H, Koyama H, Okamoto H, Nakazawa T, Nagawa H.
    • Journal Title

      International Angiology 24(4)

      Pages: 391-394

    • Data Source
      KAKENHI-PROJECT-17591322
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of isch emic skin flap.2005

    • Author(s)
      Fujihara Y, Koyama H, Eguchi T, Takto T
    • Journal Title

      British Journal of Plastic Surgery 58

      Pages: 511-517

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Preparation and biological characterization of polymeric micelle drug carries with intracellular pH-triggered property : Tumor permeability, controlled subsellular drug distribution, and enhanced in vivo antitumor efficacy2005

    • Author(s)
      Bae Y, Nishiyama N, Koyama H, Kataoka K, et al.
    • Journal Title

      Bioconjug. Chem. 16

      Pages: 122-130

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Gelatin hydrogel microspheres enable pinpoint delivery of basic fibsroblast growth factor for development of functional collateral vessels2004

    • Author(s)
      Hosaka A, Koyama H, Takato T et al.
    • Journal Title

      Circulation 110

      Pages: 3322-3328

    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Inflammatory signaling pathway containing TRAF6 contributes to neointimal formation via diverse mechanisms.2004

    • Author(s)
      Miyahara T.Koyama H.Inoue J.Takato T et al.
    • Journal Title

      Cardiovascular Research. 64

      Pages: 154-164

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind limb ischemia.2004

    • Author(s)
      Ishii S, Koyama H, Miyata T et al.
    • Journal Title

      Journal of Vascular Surgery 39

      Pages: 629-638

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.2004

    • Author(s)
      Miyata K, Koyama H, Kataoka K et al.
    • Journal Title

      Journal of American Chemical Society 126

      Pages: 2355-2361

    • Data Source
      KAKENHI-PROJECT-16390506
  • [Journal Article] Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor2004

    • Author(s)
      Kondoh K, Koyama H, Miyata T et al.
    • Journal Title

      Cardiovascular Research 61

      Pages: 132-142

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Gelatin hydrogel microspheres enable pinpoint delivery of basic fibrobl ast growth factor for the development of functional collateral vessels.2004

    • Author(s)
      Hosaka A, Koyama H, Tabata N, Takato et al.
    • Journal Title

      Circulation 110

      Pages: 3322-3328

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Inflammatory signaling pathway containing TRAF6 contributes to neoinitimal formation via diverse mechanisms.2004

    • Author(s)
      Miyahara T, Koyama H, Inoue J, Takto T
    • Journal Title

      Cardiovascular Research 64

      Pages: 154-164

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for development of functional collateral vessels.2004

    • Author(s)
      Hosaka A, Koyama H, Miyata T, Nishiyama N et al.
    • Journal Title

      Circulation 110

      Pages: 3322-3328

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for development of functional collateral vessels2004

    • Author(s)
      Hosaka A, Koyama H, Takato T et al.
    • Journal Title

      Circulation 110

      Pages: 3322-3328

    • Data Source
      KAKENHI-PROJECT-16390506
  • [Journal Article] Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.2004

    • Author(s)
      Miyata K, Koyama H, Kataoka K et al.
    • Journal Title

      Journal of American Chemical Society 126

      Pages: 2355-2361

    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Inflammatory signaling pathway containing TRAF6 contributes to neointimal formation via diverse mechanisms.2004

    • Author(s)
      Miyahara T, Koyama H, Takato T et al.
    • Journal Title

      Cardiovascular Research 64

      Pages: 154-164

    • Data Source
      KAKENHI-PROJECT-16390506
  • [Journal Article] Gelatin hydrogel microspheres enable pinpoint delivery of basic fibroblast growth factor for the development of functional collateral vessels.2004

    • Author(s)
      Hosaka A.Koyama H.Tabata N.Takato et al.
    • Journal Title

      Circulation 110

      Pages: 3322-3328

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390536
  • [Journal Article] Aortic wall cell proliferation via bFGF gene transfer limits progression of experimental abdominal aortic aneurysm2004

    • Author(s)
      Hoshina K, Koyama H, Miyata T et al.
    • Journal Title

      Journal of Vascular Surgery 40

      Pages: 512-518

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Block catiomer polyplexes with regulated densities of charge and disulfide cross-linking directed to enhance gene expression.2004

    • Author(s)
      Miyata K, Koyama H, Nishiyama N, Kataoka, K et al.
    • Journal Title

      Journal of American Chemical Society 126

      Pages: 2355-2361

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor.2004

    • Author(s)
      Kondoh K, Koyama H, Takato T et al.
    • Journal Title

      Cardiovascular Research 61

      Pages: 132-142

    • Data Source
      KAKENHI-PROJECT-16390506
  • [Journal Article] Inflammatory signaling pathway containing TRAF6 contributes to neointimal formation via diverse mechanisms.2004

    • Author(s)
      Miyahara T, Koyama H, Miyata T et al.
    • Journal Title

      Cardiovascular Research 64

      Pages: 154-164

    • Data Source
      KAKENHI-PROJECT-15390373
  • [Journal Article] Conduction performance of collateral vessels induced by vascular endothelial growth factor or basic fibroblast growth factor.2003

    • Author(s)
      Kondoh K, Koyama H, Mi yata T, Takato T, Hamada H, Shigematsu H.
    • Journal Title

      Cardiovascular Research (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Exvivo gene transfer of basic fibroblast growth factor improves cardiac function and blood flow in a swine chronic myocardial ischemia model2003

    • Author(s)
      Ninomiya M, Koyama H, Miyata T, Hamada H, Miyatake S, Shigematsu H, Takamoto S.
    • Journal Title

      Gene Therapy 10

      Pages: 1152-1160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Long-term survival after surgical treatment of patients with Takayasu's arteritis.2003

    • Author(s)
      Miyata T, Sato O, Koyama H, Shigematsu H, Tada Y.
    • Journal Title

      Circulation 108

      Pages: 1474-1480

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Long-term survival after surgical treatment of patients with Takayasu's arteritis.2003

    • Author(s)
      Miyata T, Sato O, Koyama H, Shigematsu H, Tada Y
    • Journal Title

      Circulation 108

      Pages: 1474-1480

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind limb ischemia2003

    • Author(s)
      Ishii S, Koyama H, Miyata T, Nishikage S, Hamada H, Miyatake S, Shigematsu H
    • Journal Title

      Journal of Vascular Surgery (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Conduction performance of collateral vessels induced by vascular endothelial growth factor or basicfibroblast growth factor.2003

    • Author(s)
      Kondoh K, Koyama H, Miyata T, Takato T, Hamada H, Shigematsu H
    • Journal Title

      Cardiovascular Research (In press)

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Ex vivo gene transfer of basic fibroblast growth factor improves cardiac function and blood flow in a swine chronic myocardial ischemia model2003

    • Author(s)
      Ninomiya M, Koyama H, Miyata T, Hamada H, Miyatake S, Shigematsu H, Takamoto S
    • Journal Title

      Gene Therapy 10

      Pages: 1152-1160

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Appropriate control of ex vivo gene therapy delivering basic fibroblast growth factor promotes successful and safe development of collateral vessels in rabbit model of hind I imbischemia.2003

    • Author(s)
      Ishii S, Koyama H, Miyata T, Nishikage S, Hamada H, Miyatake S, Shigematsu H.
    • Journal Title

      Journal of Vascular Surgery (in press)

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Pathogenetic heterogeneity of in-stent lesion formation in human peripheral arterial disease.2002

    • Author(s)
      Inoue S, Koyama H, Miyata T, Shigematsu H.
    • Journal Title

      Journal of Vascular surgery 35

      Pages: 672-678

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Pathogenetic heterogeneity of in-stent lesion formation in human peripheral arterial disease.2002

    • Author(s)
      Inoue S, Koyama H, Miyata T, Shigematsu H
    • Journal Title

      Journal of Vascular Surgery 35

      Pages: 672-678

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Cell replication i nduces i n-stent I es i on growth in a rabbit carotid artery with preexisting intimal hyperplasia2002

    • Author(s)
      Inoue S, Koyama H, Miyata T, Shigematsu H.
    • Journal Title

      Atherosclerosis 162

      Pages: 345-353

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Cell replication induces in-stent lesion growth in a rabbit carotid artery with preexisting intimal hyperplasia2002

    • Author(s)
      Inoue S, Koyama H, Miyata T, Shigematsu H
    • Journal Title

      Atherosclerosis 162

      Pages: 345-353

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12470236
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap

    • Author(s)
      Fujihara Y, Koyama H, Eguchi T, Takato T
    • Journal Title

      British Journal of Plastic Surgery (In press)

    • Data Source
      KAKENHI-PROJECT-16390506
  • [Journal Article] Gene transfer of bFGF to recipient bed improves survival of ischemic skin flap

    • Author(s)
      Fujihara Y, Koyama H, Eguchi T, Takato T
    • Journal Title

      British Journal of Plastic Surgery (In press)

    • Data Source
      KAKENHI-PROJECT-15390536
  • [Patent] 酸化オリゴ糖で架橋したゲル材料2012

    • Inventor(s)
      小山博之ら
    • Industrial Property Rights Holder
      小山博之ら
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-118380
    • Filing Date
      2012-05-24
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Patent] 酸化オリゴ糖で架橋したゲル材料2012

    • Inventor(s)
      上村渉、小山博之
    • Industrial Property Rights Holder
      東京大学
    • Industrial Property Number
      2012-118380
    • Filing Date
      2012-05-24
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Presentation] 急性下肢虚血に対するナノ粒子を用いた新たな治療戦略の探求2016

    • Author(s)
      須原 正光、小山 博之、三浦 裕、片岡 一則、保科 克行、渡邉 聡明
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府堺市)
    • Year and Date
      2016-03-17
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 立体組織再生を目指した足場材料: アテロコラーゲンをオリゴ糖酸化物で架橋した三次元培養基材の開発2016

    • Author(s)
      上村 渉、望月 康晃、小山 博之、渡邉 聡明、髙戸 毅
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府堺市)
    • Year and Date
      2016-03-19
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 立体組織再生のための足場材料: アテロコラーゲン-シクロデキストリン酸化物架橋ゲルを用いた三次元培養2016

    • Author(s)
      上村 渉、望月 康晃、小山 博之、渡邉 聡明、髙戸 毅
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場(大阪府堺市)
    • Year and Date
      2016-03-18
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 大型再生組織の構築を目指した足場材料:オリゴ糖酸化物で架橋した血管網誘導ゲルの 開発2015

    • Author(s)
      望月 康晃、上村渉、小山博之、渡邉聡明
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 組織移植のための血管網誘導足場基材:オリゴ糖酸化物で架橋したアテロコラーゲンゲ ルの開発2015

    • Author(s)
      上村渉、小山博之、渡邉聡明
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 移植可能な三次元培養基材:オリゴ糖酸化物によるゲル架橋システムの開発2015

    • Author(s)
      上村渉、小山博之、渡邉聡明
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2015-03-19
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 血管網の発達を促す微小環境を構築するための新規マテリアル開発2013

    • Author(s)
      小山博之ら
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-03-23
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Presentation] オリゴ糖酸化物-アテロコラーゲンゲルの開発2013

    • Author(s)
      上村渉、小山博之、組織再生用三次元細胞培養システム
    • Organizer
      第12回日本再生医療学会総会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2013-03-21
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Presentation] Selective and Sustained Delivery of bFGF for the Development of Collateral Vessels2010

    • Author(s)
      Koyama H
    • Organizer
      The 11th Annual Congress of Asian Society for Vascular Surgery
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-07-02
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Presentation] 立体的な組織の再生を目指した血管誘導ゲルの開発2010

    • Author(s)
      服部理恵子, 小山博之, ら
    • Organizer
      日本再生医療学会、第9回総会、口演
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Presentation] Selective and Sustained Delivery of bFGF for the Development of Collatoral Vessels2010

    • Author(s)
      Koyama H
    • Organizer
      The 11th Annual Congress of Asian Society for Vascular Surgery
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-07-02
    • Data Source
      KAKENHI-PROJECT-22390245
  • [Presentation] Selective and Sustained Delivery of bFGF for the Development of Collateral Vessels2010

    • Author(s)
      Koyama H
    • Organizer
      The 11th Annual Congress of Asian Society for Vascular Surgery
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-07-02
    • Data Source
      KAKENHI-PROJECT-22390245
  • [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice2008

    • Author(s)
      Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y., Iino M., Takato T.
    • Organizer
      8th Asian Congress on Oral and Maxillofacial Surgery
    • Data Source
      KAKENHI-PROJECT-20390508
  • [Presentation] Improvement in Wound Healing by a Novel Synthetic Collagen-gel Dressing in Diabetic Mice2008

    • Author(s)
      Chikazu D, Taguchi T, Koyama H, Hikiji H, Fujihara H, Suenaga H, Saijo H, Mori Y., Iino M., and Takato T
    • Organizer
      8th Asian Congress on Oral and Maxillofacial Surgery
    • Data Source
      KAKENHI-PROJECT-20390508
  • [Presentation] bFGF蛋白の経動脈的ピンポイントデリバリー法による血管再生療法2008

    • Author(s)
      橋本拓也, 小山博之, ら
    • Organizer
      日本血管外科学会、第36回総会シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-04-18
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Presentation] The Technological State and Prospect for Three-dimensional Complex Organ Structures2008

    • Author(s)
      小山博之
    • Organizer
      Bio Japan 2008
    • Place of Presentation
      横浜
    • Year and Date
      2008-10-16
    • Data Source
      KAKENHI-PROJECT-19390510
  • [Presentation] 移植部位選択に焦点をあてた自家単核球細胞を用いた血管新生療法の研究

    • Author(s)
      根本 卓、小山博之、宮田哲郎、渡邉聡明
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 血管網の発達を促す微小環境を構築するための新規マテリアル開発

    • Author(s)
      小山博之
    • Organizer
      第12回 日本再生医療学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22390244
  • [Presentation] 組織再生を目指した三次元培養基材:アテロコラーゲン-酸化オリゴ糖架橋ゲルの開発

    • Author(s)
      上村 渉、小山博之、宮田哲郎
    • Organizer
      第13回日本再生医療学会総会
    • Place of Presentation
      京都
    • Data Source
      KAKENHI-PROJECT-25293273
  • [Presentation] 組織再生用三次元細胞培養システム:オリゴ糖酸化物-アテロコラーゲンゲルの開発

    • Author(s)
      上村渉、小山博之
    • Organizer
      第12回 日本再生医療学会総会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-22390244
  • []

  • 1.  MIYATA Tetsuro (70190791)
    # of Collaborated Projects: 19 results
    # of Collaborated Products: 37 results
  • 2.  SHIGEMATSU Kunihiro (20215966)
    # of Collaborated Projects: 12 results
    # of Collaborated Products: 3 results
  • 3.  OKAMOTO Hiroyuki (60348266)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 1 results
  • 4.  KIMURA Hideo (60327070)
    # of Collaborated Projects: 8 results
    # of Collaborated Products: 0 results
  • 5.  SHIGEMATSU Hiroshi (40134556)
    # of Collaborated Projects: 7 results
    # of Collaborated Products: 14 results
  • 6.  KATAOKA Kazunori (00130245)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 14 results
  • 7.  TAKATO Tsuyoshi (90171454)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 14 results
  • 8.  HAMADA Hirohumi (00189614)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 12 results
  • 9.  MIURA Yutaka (40557980)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 10.  HOSHINA Katsuyuki (90571761)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 2 results
  • 11.  CHIKAZU Daichi (30343122)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 1 results
  • 12.  OSHIRO Hidemi (80272558)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 0 results
  • 13.  OBA Makoto (20396716)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 17 results
  • 14.  HIKIJI Hisako (50292876)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 15.  ISHII Satoshi (10300815)
    # of Collaborated Projects: 2 results
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  • 16.  NISHIYAMA Nobuhiro (10372385)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 12 results
  • 17.  TABATA Yasuhiko (50211371)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 18.  EGUCHI Tomoaki (00302688)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 4 results
  • 19.  出口 順夫 (50242053)
    # of Collaborated Projects: 2 results
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  • 20.  MORI Yoshiyuki (70251296)
    # of Collaborated Projects: 1 results
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  • 21.  YONEHARA Hiroyuki (00251299)
    # of Collaborated Projects: 1 results
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  • 22.  MATSUMOTO Yoichiro (60111473)
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  • 23.  FUKAYAMA Masahisa (70281293)
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  • 24.  NISHIHARA Tatsuji (80192251)
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  • 25.  NAKAMURA Motonao (40431762)
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  • 26.  TAKAHASH Yukiko (10582778)
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  • 27.  ASAKURA Tetsuo (30139208)
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  • 28.  Nishiyama Ayako (90705526)
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  • 29.  KUROHMARU Masamichi (00148636)
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  • 30.  SATO Osamu (40170724)
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  • 32.  HOSOI Yutaka (40311625)
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  • 37.  MIZUKAMI Hiroaki (20311938)
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  • 38.  石井 誠之 (80365197)
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 46.  Cabral Horacio (10533911)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 47.  宮原 拓也 (20704943)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 48.  SHIMIZU Takao
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 49.  SUHARA Masamitsu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 50.  KOBAYASHI Hisatoshi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 51.  ITAKA Keiji
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 52.  赤木 大輔
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

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