• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

takaki satoshi  高木 智

ORCIDConnect your ORCID iD *help
… Alternative Names

高木 智  タカキ サトシ

TAKAKI Satoshi  高木 智

Less
Researcher Number 10242116
Other IDs
Affiliation (Current) 2025: 国立健康危機管理研究機構, 国立国際医療研究所肝炎・免疫研究センター, 部長
Affiliation (based on the past Project Information) *help 2025: 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長
2022 – 2023: 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長
2019 – 2020: 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長
2017 – 2018: 国立研究開発法人国立国際医療研究センター, 研究所, 免疫制御研究部長
2016 – 2017: 国立研究開発法人国立国際医療研究センター, その他部局等, 免疫制御研究部長 … More
2015: 国立研究開発法人国立国際医療研究センター, 研究所, 免疫制御研究部長
2015: 国立国際医療研究センター, 免疫制御研研究部, 部長
2013 – 2014: 独立行政法人国立国際医療研究センター, 研究所, 免疫制御研究部長
2012: 独立行政法人国立国際医療研究センター, 研究所 免疫制御研究部, 部長
2011 – 2012: 独立行政法人国立国際医療研究センター, 研究所・免疫制御研究部, 部長
2010: 独立行政法人国立国際医療研究センター, 研究所免疫制御研究部, 部長
2009: Research Institute, International Medical Center of Japan, 地域保健医療研究部, 部長
2006 – 2009: International Medical Center ofJapan (Research Institute), Department of Community Health and Medicine, Director, 地域保健医療研究部, 部長
2008: 国立国際医療センター, 研究所, 部長
2007: 国立国際医療センター研究所, 部長
2006: 国立国際医療センター, 研究所, 部長
1999 – 2005: Institute of Medical Science, The University of Tokyo, Associate Professor, 医科学研究所, 助教授
1999: 東京大学, 医学研究所, 助教授
1997 – 1998: 東京大学, 医科学研究所, 助手
1993 – 1995: 東京大学, 医科学研究所, 助手
1993: 東京大学, 医科学研究所・免疫学研究部, 助手
1992 – 1993: 東京大学, 医科学研究所, 教務職員 Less
Review Section/Research Field
Principal Investigator
Biological Sciences / Immunology / Immunology / Basic Section 49070:Immunology-related / Experimental pathology / Complex Systems Disease Theory
Except Principal Investigator
Immunology / Biological Sciences / Gastroenterology / Infectious disease medicine / Immunology
Keywords
Principal Investigator
シグナル伝達 / アダプター蛋白質 / 免疫学 / サイトカイン / リンパ球 / 骨髄移植 / Lnk / 再生医学 / B細胞 / 発生・分化 … More / 細胞増殖 / 再生医療 / 造血幹細胞 / Signal transduction / B細胞分化 / 疾患関連遺伝子 / 自己免疫 / 細胞骨格系 / 細胞接着 / 移植・再生医療 / 細胞・組織 / サイトカイン受容体 / アレルギー / 好酸球 / Bone marrow transfer / Regenerative medicine / signal transduction / B cell / adaptor protein / APS / c-Kit / B cell development / Adaptor protein / リンパ球分化 / 糖尿病 / 転写因子 / インテグリン / 感染症 / 脂質代謝物 / 炎症 / 肥満 / 脂肪組織 / 脂肪炎症 / 慢性炎症 / 耐糖能異常 / Transcription factor / Transplantation / Infectious disease / Immunology / Actin cytoskeleton / Mast cell / Cell proliferation / アクチン細胞骨格 / 肥満細胞 / hematopoietic stem cell / B lymphocyte / bone marrow transfer / regenerative medicine / cell growth / immunology / SH2-B / 増殖、分化 / hematopoiesis / tyrosine kinase / 造血 / チロシンキナーゼ受容体 / 細胞内アダプター蛋白質 / Lymphocyte development / ノックアウトマウス / 細胞内蛋白質 / 骨髄増殖性疾患 / 高血圧 / 免疫寛容 / レパトア / 細胞分化 / 抗体 / 発生・文化 / インテダリン / 接着分子 / 遺伝子欠損マウス / 遺伝子治療 / 感染防御 / IgA / 免疫グロブリン / 抗体産生 / 粘膜免疫 / 遺伝子導入 / サイトカインレセプター / IL-5レセプター / IL-5 … More
Except Principal Investigator
IL-5 / Btk / CD38 / サイトカイン / チロシンキナーゼ / CD40 / B細胞 / Blimp-1 / Cytokine / B cell differentiation / B細胞分化 / APS / IgA / アダプター分子 / シグナル伝達 / AID / IFN-γ / Peptide-25 / Ag85B / NF-κB / Stat5 / germline transcripts / IL-4 / クラス変換 / STAT5 / 細胞接着 / 接着分子 / 胚中心 / Tyrosine kinase / トランスジェニックマウス / 好酸球 / 結核菌 / クラススイッチ / B-1細胞 / リンパ球 / Bリンパ球 / 増殖・分化 / 線維化 / 炎症 / ILC2 / 自然リンパ球 / 好中球減少 / 細菌感染 / 感染症防御学 / BLIMP-1 / BTK / CLASS SWITCH RECOMBINATION / B CELLS / BAM11 / NF-KB / IgHクラススイッチ組み換え / 粘膜免疫 / ホメオスターシス / クラススイッチ組み替え / Cytotoxic Activity / Transgenic mice / Adjuvant Activity / I-A restriction / Thl-indicing Peptide / CTL / IFNγ / ペプチド-25 / ヘルパーT細胞 / α抗原 / TCRVβ11 / CpG DNA / CLT / 細胞障害活性 / アジュバント活性 / I-A拘束性 / Th1抗原ペプチド / Switch recombination / DNA組み換え / stat5 / NF-кB / マウスsIgD+B細胞 / スイッチ組み換え / IL-5 receptor / gene knock-out mouse / Peyer's patch / lamina propria / B-1 cell / IL-6 / γδ型T細胞 / リボ多糖体 / **型T細胞 / クラス交換 / リポ多糖体 / γα型 T細胞 / コレラトキシン / トレランス / 腸管粘膜固有リンパ層 / B-1 / Follicular mantle zone / X-linked immunodeficiency / CD40とリガンド / 抗体の親和性 / 超変異 / メモリーB細胞 / 細胞死 / ケモカイン / メモリー B細胞 / PI 3-kinase / JAK2 / Cell adhesion / 肥満細胞 / BtK / シグナル伝達系 / lgA / インテグリン / Cytokine receptor / B cell maturation / B cells / Germinal center / Ig-アイソタイプ変換 / サイトカイン レセプター / 増殖.分化 / D40 / サイトカインレセプター / JAK2 kinase / IL-5 Receptor / Immunodeficiency / GM-CSF / IL-3 / レセプターのクロストーク / タンパク質リン酸化 / IL-5受容体 / 免疫不全 / JAKキナーゼ / IL-5レセプター / 伴性免疫不全 / SLE / SNP / ZEAT / FCRL3 / 転写制御因子 / 遺伝子改変マウス / ZFAT / 疾患感受性遺伝子 / 相関解析 / 自己免疫性甲状腺疾患(AITD) / Lnk / クラススイッチ組換え / 造血幹細胞 / インターロイキン5 / クラススイッチ変換 / インターロイキン / 自然免疫 / 免疫学 / 分化と活性化 / lprマウス / MRL / Fyn / 抗原レセプター / チロシンリン酸化 / GM-CSF受容体 / IL-3受容体 / ヒトIL-5受容体 / 発生 / 免疫担当細胞 / 受容体 / リンホカイン Less
  • Research Projects

    (34 results)
  • Research Products

    (96 results)
  • Co-Researchers

    (51 People)
  •  IgE産生制御に関わる胚中心B細胞応答及びシグナル伝達機構の解明とその制御Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2025 – 2027
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      National Center for Global Health and Medicine
  •  IL-5/好酸球/脂質代謝軸を介する新規炎症抑制機構の解明と制御Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 49070:Immunology-related
    • Research Institution
      National Center for Global Health and Medicine
  •  Roles of disease associated gene Lnk/Sh2b3 in inflammation.Principal Investigator

    • Principal Investigator
      Takaki Satoshi
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Experimental pathology
    • Research Institution
      National Center for Global Health and Medicine
  •  Obesity-induced activation of cytokine-producing cells and eosinophils in adipose tissues.Principal Investigator

    • Principal Investigator
      Takaki Satoshi
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Complex Systems Disease Theory
    • Research Institution
      National Center for Global Health and Medicine
  •  Activation machinery of tissue-resident innate IL-5-producing cells and their roles in inflammatory diseases and fibrosis

    • Principal Investigator
      Iseki Masanori
    • Project Period (FY)
      2015 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Gastroenterology
    • Research Institution
      Kawasaki Medical School
      National Center for Global Health and Medicine
  •  Immunoregulatory function of Lnk/Sh2b3, a common risk factor gene for immune, hematopoietic and cardiovascular diseasesPrincipal Investigator

    • Principal Investigator
      Takaki Satoshi
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Experimental pathology
    • Research Institution
      National Center for Global Health and Medicine
  •  Mechanisms of impaired granulopoiesis by streptococcus toxic shock

    • Principal Investigator
      ATO Manabu
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Infectious disease medicine
    • Research Institution
      National Institute of Infectious Diseases
  •  Function of a risk factor gene common to autoimmune diseases and life-style related diseasesPrincipal Investigator

    • Principal Investigator
      TAKAKI Satoshi
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  骨髄ニッチにおける造血前駆細胞の動態と増殖のクロストーク分子機構Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  プレB細胞受容体シグナルの新規標的転写因子群とその機能Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2008 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  細胞外環境・ニッチと造血前駆細胞の相互作用における細胞動態と増殖シグナル制御Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2006 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  Immunogenetic Analysis of Autoimmune Thyroid Diseases

    • Principal Investigator
      SASAZUKI Takehiko
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
  •  造血幹細胞の抑制性シグナル制御分子とその修飾による造血能増強Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
      The University of Tokyo
  •  リンパ球前駆制御及び幹細胞の産生・維持機構と免疫監視機構の再生制御Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      Research Institute, International Medical Center of Japan
      The University of Tokyo
  •  Regulatory signals for production of immune competent cells and reconstitution of immune systemPrincipal Investigator

    • Principal Investigator
      TAKAKI Satoshi
    • Project Period (FY)
      2005 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      International Medical Centre of Japan (Research Institute)
      The University of Tokyo
  •  粘膜組織によける自然抗体・IgA抗体の産生制御及びB-1細胞の維持活性化機構Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2004 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  造血幹細胞・リンパ球前駆細胞の増幅分化制御とその免疫監視機構再生への応用Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Investigation of regulatory mechanisms for homeostasis and activation of lymphocyte

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      2004 – 2007
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
      University of Toyama
  •  造血幹細胞の増幅・維持の分子機構とその制御シグナル伝達分子Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      The University of Tokyo
  •  Lnk family adaptor proteins in the development and regulation of immune-competent cellsPrincipal Investigator

    • Principal Investigator
      TAKAKI Satoshi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  REGULATORY MECHANISMS OF IL-5 DEPENDENT IMMUNE REGULATION

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      2001 – 2003
    • Research Category
      Grant-in-Aid for Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      THE UNIVERSITY OF TOKYO
  •  Regulation of signal transduction for cell growth and differentiation by Lnk-family adaptor proteinsPrincipal Investigator

    • Principal Investigator
      TAKAKI Satoshi
    • Project Period (FY)
      2001 – 2002
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Augmented Induction of CD8+ Cytotoxic T cell Response and Antitumor Resistance by Thl-inducing peptide

    • Principal Investigator
      TAKATSU Eyoshi
    • Project Period (FY)
      2000 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      University of Tokyo
  •  Molecular mechanisms of isotype switch recombination.

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (B).
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Lnk and Lnk-family adaptor proteins in lymphocyte development.Principal Investigator

    • Principal Investigator
      TAKAKI Satoshi
    • Project Period (FY)
      1999 – 2000
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Molecular mechanisms of oral immunity : Role of IL-5 in potentiation of IgA production in mucosal lymphoid cell

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1998 – 1999
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Signaling through surface receptors in immune cells.

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Molecular mechanisms of proliferation and differentiation of germinal center B cells

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  The role of p38Lnk in lymphocyte development and activation.Principal Investigator

    • Principal Investigator
      TAKAI Satoshi
    • Project Period (FY)
      1997 – 1998
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  免疫系担当細胞の発生・分化に関与するリンホカイン及びその受容体の解析

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Research Institution
      The University of Tokyo
  •  Bリンパ球の機能分化における抗原レセプターを介した情報伝達機構の解析

    • Principal Investigator
      片桐 拓也
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for General Scientific Research (C)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  インターロイキン5受容体の活性化機構と細胞増殖Principal Investigator

    • Principal Investigator
      高木 智
    • Project Period (FY)
      1993
    • Research Category
      Grant-in-Aid for Encouragement of Young Scientists (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  Studies on the mechanisms of the maturation of germinal center B cells.

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1993 – 1995
    • Research Category
      Grant-in-Aid for General Scientific Research (A)
    • Research Field
      Immunology
    • Research Institution
      The University of Tokyo
  •  MECHANISMS OF SIGNAL TRANSDUCTION THROUGH SURFACE RECEPTORS

    • Principal Investigator
      TAKATSU Kiyoshi
    • Project Period (FY)
      1992 – 1994
    • Research Category
      Grant-in-Aid for international Scientific Research
    • Research Institution
      THE UNIVERSITY OF TOKYO

All 2024 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2009 2007 2006 2005 2004 2003 2002 Other

All Journal Article Presentation Book Patent

  • [Book] 日本臨床増刊号「臨床免疫学-基礎研究の進歩と最新の臨床-」上巻 B細胞の分化・活性化における補助シグナル2005

    • Author(s)
      高木智(分担執筆)
    • Total Pages
      710
    • Publisher
      日本臨床社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390157
  • [Book] Clinical Immunology (1) "Costimulation signals in B cell maturation and activation"2005

    • Author(s)
      Takaki S.
    • Total Pages
      710
    • Publisher
      Nippon-rinsho Co.
    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390157
  • [Book] 実験医学 別冊 Vol. 23(担当)Lnkによる造血制御 : サイトカインシグナルの新しい抑制性制御機構2005

    • Author(s)
      高木 智
    • Total Pages
      7
    • Publisher
      羊土社
    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-17390141
  • [Journal Article] Composition of fatty acids in a high-fat diet affects adipose tissue inflammation by inducing calreticulin on adipocytes and activating group 1 innate lymphoid cells.2024

    • Author(s)
      Matsumura K, Mori T, Dohi T, Kawamura YI, Takaki S.
    • Journal Title

      Eur J Immunol

      Volume: 54 Issue: 4

    • DOI

      10.1002/eji.202350800

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-22K07142
  • [Journal Article] The regulatory B cell?mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity2019

    • Author(s)
      Kim Hyuk Soon、Lee Min Bum、Lee Dajeong、Min Keun Young、Koo Jimo、Kim Hyun Woo、Park Young Hwan、Kim Su Jeong、Ikutani Masashi、Takaki Satoshi、Kim Young Mi、Choi Wahn Soo
    • Journal Title

      Science Advances

      Volume: 5 Issue: 7

    • DOI

      10.1126/sciadv.aav8152

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0132
  • [Journal Article] Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group 1 ILCs.2018

    • Author(s)
      Mori T, Suzuki-Yamazaki N, Takaki S.
    • Journal Title

      Cell Rep

      Volume: 24 Issue: 7 Pages: 1830-1841

    • DOI

      10.1016/j.celrep.2018.07.036

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17K08802, KAKENHI-PROJECT-17K15674
  • [Journal Article] Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lung inflammation.2018

    • Author(s)
      Kudo F, Ikutani M, Iseki M, Takaki S.
    • Journal Title

      Cell Immunology

      Volume: 323 Pages: 33-40

    • DOI

      10.1016/j.cellimm.2017.10.010

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-17KT0132, KAKENHI-PROJECT-15K09036, KAKENHI-PROJECT-16K19111
  • [Journal Article] IL-10 production in murine IgM+ CD138hi cells is driven by Blimp-1 and downregulated in class-switched cells.2017

    • Author(s)
      Nao Suzuki-Yamazaki
    • Journal Title

      European Journal of Immunology

      Volume: 47 Issue: 3 Pages: 493-503

    • DOI

      10.1002/eji.201646549

    • Peer Reviewed / Acknowledgement Compliant
    • Data Source
      KAKENHI-PROJECT-25860800, KAKENHI-PROJECT-15K09036
  • [Journal Article] Prolonged activation of IL-5-producing ILC2 causes pulmonary arterial hypertrophy.2017

    • Author(s)
      Ikutani M, Tsuneyama K, Kawaguchi M, Fukuoka J, Kudo F, Nakae S, Arita M, Nagai Y, Takaki S, Takatsu K.
    • Journal Title

      JCI Insight.

      Volume: 2 Issue: 7

    • DOI

      10.1172/jci.insight.90721

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K15098, KAKENHI-PROJECT-17K15739, KAKENHI-PROJECT-15K09036
  • [Journal Article] Specific disruption of Lnk in murine endothelial progenitor cells promotes dermal wound healing via enhanced vasculogenesis, activation of myofibroblasts, and suppression of inflammatory cell recruitment2016

    • Author(s)
      Jun Hee Lee, Seung Taek Ji, Jaeho Kim, Satoshi Takaki, Takayuki Asahara, Young-Joon Hong, and Sang-Mo Kwon
    • Journal Title

      Stem Cell Research & Therapy

      Volume: 7 Issue: 1 Pages: 158-158

    • DOI

      10.1186/s13287-016-0403-3

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Journal Article] Interferon-gamma Constrains Cytokine Production of Group 2 Innate Lymphoid Cells2016

    • Author(s)
      Kudo, F. Ikutani, M. Seki, Y. Otsubo, T. Kawamura, Y. I. Dohi, T. Oshima, K. Hattori, M. Nakae, S. Takatsu, K. Takaki, S.
    • Journal Title

      Immunology

      Volume: 147 Issue: 1 Pages: 21-29

    • DOI

      10.1111/imm.12537

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-15H04503, KAKENHI-PROJECT-25460965, KAKENHI-PROJECT-25293097
  • [Journal Article] Lymphocyte adaptor protein LNK deficiency exacerbates hypertension and end-organ inflammation.2015

    • Author(s)
      Saleh MA, McMaster WG, Wu J, Norlander AE, Funt SA, Thabet SR, Kirabo A, Xiao L, Chen W, Itani HA, Michell D, Huan T, Zhang Y, Takaki S, Titze J, Levy D, Harrison DG, Madhur MS.
    • Journal Title

      J Clin Invest.

      Volume: 125 Issue: 3 Pages: 1189-1202

    • DOI

      10.1172/jci76327

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Journal Article] Nov/ccn3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ32014

    • Author(s)
      J. Ishihara, et al
    • Journal Title

      International Journal of Hematology

      Volume: (印刷中) Issue: 4 Pages: 393-406

    • DOI

      10.1007/s12185-014-1534-x

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-13J00246, KAKENHI-ORGANIZER-22118001, KAKENHI-PLANNED-22118002, KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-23249051, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24300160, KAKENHI-PROJECT-25293097
  • [Journal Article] Lnk/Sh2b3 controls the production and function of dendritic cells, regulates the induction of IFN-gamma-producing T cells.2014

    • Author(s)
      Mori T., Iwasaki Y., Seki Y., Iseki M., Katayama H., Yamamoto K., Takatsu K., Takaki S.
    • Journal Title

      The Journal of Immunology

      Volume: 193 Issue: 4 Pages: 1728-36

    • DOI

      10.4049/jimmunol.1303243

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-25293097
  • [Journal Article] Lnk prevents inflammatory CD8+ T-cell proliferation and contributes to intestinal homeostasis.2014

    • Author(s)
      Katayama H., Mori T., Seki Y., Anraku M., Iseki M., Ikutani M., Iwasaki Y., Yoshida N., Takatsu K., Takaki S.
    • Journal Title

      European Journal of Immunology

      Volume: 44 Issue: 6 Pages: 1622-1632

    • DOI

      10.1002/eji.201343883

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24390119, KAKENHI-PROJECT-24890297, KAKENHI-PROJECT-25293097
  • [Journal Article] Generation of engraftable hematopoietic stem cells from induced pluripotent stem cells by way of teratoma formation.2013

    • Author(s)
      Suzuki N, Yamazaki S, Yamaguchi T, Okabe M, Masaki H, Takaki S, Otsu M, Nakauchi H.
    • Journal Title

      Mol Ther.

      Volume: 21 Issue: 7 Pages: 1424-31

    • DOI

      10.1038/mt.2013.71

    • Peer Reviewed
    • Data Source
      KAKENHI-PLANNED-23106004, KAKENHI-PROJECT-24249056, KAKENHI-PROJECT-24659127, KAKENHI-PROJECT-25293097, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
  • [Journal Article] TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice2013

    • Author(s)
      Son A, Oshio T, Kawamura YI, Hagiwara T, Yamazaki M, Inagaki-Ohara K, Okada T, Wu P, Iseki M, Takaki S, Burkly LC, Dohi T
    • Journal Title

      Mucosal Immunology

      Volume: 6 Issue: 6 Pages: 1131-1142

    • DOI

      10.1038/mi.2013.10

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23590955, KAKENHI-PROJECT-25293097
  • [Journal Article] Adipose natural regulatory B cells negatively control adipose tissue inflammation2013

    • Author(s)
      Nishimura S, Manabe I, Takaki S, Nagaskai M, Ostu M, Yamashita H, Sugita J, Yoshimura K, Eto K, Komuro I, Kadowaki T, Nagai R
    • Journal Title

      Cell Metabolism

      Volume: 18 Issue: 5 Pages: 759-766

    • DOI

      10.1016/j.cmet.2013.09.017

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-23591298, KAKENHI-PUBLICLY-24117703, KAKENHI-PROJECT-25293097, KAKENHI-PROJECT-25670471, KAKENHI-PROJECT-25670489
  • [Journal Article] Structural basis of interleukin-5 dimer recognition by its alpha receptor2012

    • Author(s)
      Kusano S., Kukimoto-Niino M., Hino N., Ohsawa N., Ikutani M., Takaki S., Sakamoto K., Hara-Yokoyama M., Shirouzu M., Takatsu K., Yokoyama S
    • Journal Title

      Protein Sci

      Volume: 21 Issue: 6 Pages: 850-864

    • DOI

      10.1002/pro.2072

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22570175, KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-24390119
  • [Journal Article] Inhibition of Lnk in mouse induced pluripotent stem cells promotes hematopoietic cell generation.2012

    • Author(s)
      Tashiro K, Omori M, Kawabata K, Hirata N, Yamaguchi T, Sakurai F, Takaki S, Mizuguchi H
    • Journal Title

      Stem Cells Dev.

      Volume: 21 Issue: 18 Pages: 3381-3390

    • DOI

      10.1089/scd.2012.0100

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-23790123
  • [Journal Article] Thymic stromal lymphopoietin(TSLP)-induced polyclonal B-cell activation and autoimmunity are mediated by CD4^+T cells and IL-42012

    • Author(s)
      Iseki M, Omori-Miyake M, Xu W, Sun X, Takaki S, Rawlings DJ, Ziegler SF
    • Journal Title

      International Immunology

      Volume: Vol.24 Issue: 3 Pages: 183-195

    • DOI

      10.1093/intimm/dxr113

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790488, KAKENHI-PROJECT-22590446
  • [Journal Article] Identification of innate IL-5-producing cells and their role in lung eosinophil regulation and antitumor immunity2012

    • Author(s)
      Ikutani M.
    • Journal Title

      J Immunol

      Volume: 188(2) Issue: 2 Pages: 703-713

    • DOI

      10.4049/jimmunol.1101270

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21590433, KAKENHI-PUBLICLY-22117509, KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-22590447, KAKENHI-PROJECT-23659247, KAKENHI-PUBLICLY-23122506
  • [Journal Article] Homeostasis of hematopoietic stem cells regulated by the myelop roliferative disease associated-gene product Lnk/Sh2b3 via Bcl-xL2012

    • Author(s)
      Suzuki N, Yamazaki S, et al
    • Journal Title

      Exp Hematol

      Volume: 40 Issue: 2 Pages: 166-174

    • DOI

      10.1016/j.exphem.2011.11.003

    • Peer Reviewed
    • Data Source
      KAKENHI-PUBLICLY-22019005, KAKENHI-PROJECT-22590446, KAKENHI-PROJECT-22591029, KAKENHI-PUBLICLY-23118505
  • [Journal Article] Octa-arginine mediated delivery of wild-type Lnk protein inhibits TPO-induced M-MOK megakaryoblastic leukemic cell growth by promoting apoptosis.2011

    • Author(s)
      Looi CY, Imanishi M, Takaki S, Sato M, Chiba N, Sasahara Y, Futaki S, Tsuchiya S, Kumaki S
    • Journal Title

      PLoS One

      Volume: 6(8) Issue: 8 Pages: e23640-e23640

    • DOI

      10.1371/journal.pone.0023640

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Journal Article] Lnk-dependent axis of SCF-cKit signal for osteogenesis in bone fracture healing.2010

    • Author(s)
      Matsumoto T, Ii M, Nishimura H, Shoji T, Mifune Y, Kawamoto A, Kuroda R, Fukui T, Kawakami Y, Kuroda T, Kwon SM, Iwasaki H, Horii M, Yokoyama A, Oyamada A, Lee SY, Hayashi S, Kurosaka M, Takaki S, Asahara T
    • Journal Title

      J Exp Med

      Volume: 207 Issue: 10 Pages: 2207-2223

    • DOI

      10.1084/jem.20100321

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Journal Article] Enhanced engraftment of hematopoietic stem/progenitor cells by the transient inhibition of an adaptor protein2006

    • Author(s)
      Takizawa H, Kubo-Akashi C, Nobuhisa I, Kwon S.-M., Iseki M, Taga T, Takatsu K, Takaki S
    • Journal Title

      Lnk, Blood 107

      Pages: 2968-2975

    • Data Source
      KAKENHI-PROJECT-16109004
  • [Journal Article] The role of interleukin-5 for mature B-1 cells in homeostatic proliferation cell survival and Ig production2004

    • Author(s)
      Moon, BG., Takaki, S., Miyake, K., Takatsu, K.et al.
    • Journal Title

      Journal of Immunology 172・10

      Pages: 6020-6029

    • Data Source
      KAKENHI-PROJECT-12213025
  • [Journal Article] The role of IL-5 for mature B-1 cells in homeostatic proliferation, cell survival, and Ig production2004

    • Author(s)
      Moon B.-G., Takaki S, Miyake K, Takatsu K. J. Immunol
    • Journal Title

      J. Immunol 172

      Pages: 6020-6029

    • Data Source
      KAKENHI-PROJECT-16109004
  • [Journal Article] The role of antigenic peptide in CD4+ T helper phenotype development in a T cell receptor transgenic model.2004

    • Author(s)
      Tamura, T., Ariga, H., Kinashi, T., Uehara, S., Kikuchi, T., Nakada, M., Tokunaga, T., Xu, W., Kariyone, A., Saito, T., Kitamura, T., Maxwell, G., Takaki, S., Takatsu, K.
    • Journal Title

      International Immunology 16(12)

      Pages: 1691-1699

    • NAID

      10014207554

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213025
  • [Journal Article] Roles of a conserved family of adaptor proteins, Lnk, SH2-B, and APS, for mast cell development, growth, and functions : APS-deficiency causes augmented degranulation and reduced actin assembly2004

    • Author(s)
      Kubo-Akashi, C., Iseki, M.., Takatsu, K., Takaki, S.et al.
    • Journal Title

      Biochemical and Biophysical Research Communications 315・2

      Pages: 356-362

    • Data Source
      KAKENHI-PROJECT-12213025
  • [Journal Article] The role of antigenic peptide in CD4^+ T helper phenotype development in a T cell receptor transgenic model2004

    • Author(s)
      Tamura T, Ariga H, Kinashi T, Uehara S, Kikuchi T, Nakada M, Tokunaga T, Kariyone A, Saito T, Kitamura T, Maxwell G, Takaki S, Takatsu K
    • Journal Title

      Int. Immunol 15

      Pages: 1691-1699

    • NAID

      10014207554

    • Data Source
      KAKENHI-PROJECT-16109004
  • [Journal Article] Increased Numbers of B-1 Cells and Enhanced Responses against TI-2 Antigen in Mice Lacking APS, an Adaptor Molecule Containing PH and SH2 Domains2004

    • Author(s)
      Iseki, M., Kubo, C., Takatsu, K., Takaki, S.et al.
    • Journal Title

      Molecular and Cellular Biology 24・6

      Pages: 2243-2250

    • Data Source
      KAKENHI-PROJECT-12213025
  • [Journal Article] Impaired lymphopoiesis and altered B cell subpopulations in mice overexpressing Lnk adaptor protein.2003

    • Author(s)
      Takaki, S.
    • Journal Title

      J.Immunol. 170・2

      Pages: 703-710

    • Data Source
      KAKENHI-PROJECT-15039208
  • [Journal Article] Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk2002

    • Author(s)
      Takaki, S., Morita, H., Tezuka, Y., Takatsu, K.
    • Journal Title

      Journal of Experimental Medicine 195・2

      Pages: 151-160

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-12213025
  • [Journal Article] Enhanced hematopoiesis by hematopoietic progenitor cells lacking intracellular adaptor protein, Lnk.2002

    • Author(s)
      Takaki S, Morita H, Tezuka Y, Takatsu K.
    • Journal Title

      Journal of Experimental Medicine 195(2)

      Pages: 151-160

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-12213025
  • [Patent] Lnk の機能が破壊又は抑制されている血管内皮細胞2011

    • Inventor(s)
      コン サンモ、浅原 孝之、高木 智
    • Industrial Property Rights Holder
      学校法人東海大学
    • Acquisition Date
      2011-09-16
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Lnk/SH2B3 contributes to the initiation and severity of STZ-induced diabetes.2019

    • Author(s)
      Tenno M, Takaki S.
    • Organizer
      第48回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08802
  • [Presentation] Disruption of Lnk/SH2B3 increases severity of STZ-induced diabetes.2018

    • Author(s)
      Tenno M, Takaki S.
    • Organizer
      第47回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08802
  • [Presentation] Characterization of ILC2 in IL-33-induced chronic inflammation.2018

    • Author(s)
      Ikutani M, Tsuneyama K, Nakae S, Takatsu K, Takaki S.
    • Organizer
      第47回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17KT0132
  • [Presentation] Disruption of Lnk increases severity of DSS-induced acute colonic inflammation.2017

    • Author(s)
      Tenno M, Takaki S.
    • Organizer
      第46回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08802
  • [Presentation] Disruption of Lnk increases severity of dextran sulfate sodium-induced acute colonic inflammation2017

    • Author(s)
      Mari Tenno, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Activation of NK/group1-innate lymphoid cells in adipose tissues depends on the composition of fatty acids in high fat diet2017

    • Author(s)
      Yukari Saito, Taizo Mori, Yuki I. Kawamura, Taeko Dohi, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group1-ILCs.2017

    • Author(s)
      Mori T, Yamazaki N, Takaki S.
    • Organizer
      第46回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K08802
  • [Presentation] Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group1-ILCs2017

    • Author(s)
      Taizo Mori, Nao Yamazaki, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Chronic IL-33-induced inflammation results in pulmonary arterial hypertrophy2017

    • Author(s)
      Masashi Ikutani, Koichi Tsuneyama, Susumu Nakae, Kiyoshi Takatsu, Satoshi Takaki
    • Organizer
      The 46th Annual Meeting of The Japanese Society for Immunology
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Chronic IL-33-induced inflammation results in pulmonary arterial hypertrophy.2017

    • Author(s)
      Ikutani M, Tsuneyama K, Nakae S, Takatsu K, Takaki S.
    • Organizer
      第46回 日本免疫学会学術集会
    • Data Source
      KAKENHI-PROJECT-17KT0132
  • [Presentation] IL-5-producing ILC2s and eosinophils in the development of pulmonary arteriopathy.2017

    • Author(s)
      Takaki S.
    • Organizer
      The 5th Annual Meeting of the International Cytokine and Interferon Society, Cytokines 2017.
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-17KT0132
  • [Presentation] IL-10 derived from IgM+CD138hi cells support the antigen-specific antibody production2016

    • Author(s)
      Nao YAMAZAKI, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Chronic IL-33 treatment results in pulmonary arterial hypertrophy mediated by ILC2s and eosinophils2016

    • Author(s)
      Masashi IKUTANI, Koichi TSUNEYAMA, Fujimi KUDO, Kiyoshi TAKATSU, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Lnk/Sh2b3, and autoimmune disease-associated gene, prevents adipose tissue inflammation by controlling IL-15-dependent cell fuctions2016

    • Author(s)
      Taizo MORI, Nao YAMAZAKI, Satoshi TAKAKI
    • Organizer
      The 45th Annual Meeting of the Japanese Society for Immunology
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-12-06
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Lnk/Sh2bファミリーアダプター分子Aps/Sh2b2による胚中心形 成およびIgE産生制御2015

    • Author(s)
      井関將典、工藤藤美、高木智
    • Organizer
      第1回3NC合同リトリート
    • Place of Presentation
      国立国際医療研究センター(戸山)
    • Year and Date
      2015-08-18
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] Germinal center B cell survival and optimal IgE production are controled by Lnk/Sh2b family adaptor protein Aps/Sh2b2.2015

    • Author(s)
      Iseki M, Kudo F, Takaki S.
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Inhibitory effects of interferon-γ on cytokine production in group 2 innate lymphoid cells.2015

    • Author(s)
      Kudo F, Takaki S.
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Germinal center B cell survivial and optimal IgE production are controled by Lnk/Sh2b family adaptor protein Aps/Sh2b22015

    • Author(s)
      井関將典、工藤藤美、高木智
    • Organizer
      第44回日本免疫学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-15K09036
  • [Presentation] An autoimmune disease-associated gene, Lnk/Sh2b3 controls inflammation in adipose tissue and reduces the risk for onset of diabetes.2015

    • Author(s)
      Mori T, Yamazaki N, Takaki S.
    • Organizer
      第44回 日本免疫学会学術集会
    • Place of Presentation
      札幌
    • Year and Date
      2015-11-18
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Lnk/Sh2b3 adaptor protein prevents the accumulation of inflammatory CD8+ T cells and intestinal villous atrophy.2013

    • Author(s)
      Seki Y, Katayama H, Mori T, Iseki M, Takaki S.
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] IgE production and germinal center formation are regulated by the adaptor protein Aps/Sh2b2 in B cells.2013

    • Author(s)
      Iseki M, Kudo F, Takaki S.
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Lnk/Sh2b3, an intracellular adaptor associated with celiac disease and autoimmune diabetes, regulates accumulation of inflammatory T cells and prevents intestinal villous atrophy. The 15th International Congress of Immunology.2013

    • Author(s)
      Mori T, Katayama H, Iwasaki Y, Seki Y, Iseki M, Ikutani M, Yoshida N, Takatsu K, Takaki S.
    • Organizer
      The 15th International Congress of Immunology
    • Place of Presentation
      Milan, Italy
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] An autoimmune disease-associated gene, Lnk/SH2B3 controls production and functions of DC subsets and regulates inflammatory T cell differentiation.2013

    • Author(s)
      Mori T, Seki Y, Iwasaki Y, Yamazaki-Suzuki N, Iseki M, Takaki S.
    • Organizer
      第42回 日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] IgE production is under the control of the Sh2b adaptor protein family, Aps/Sh2b2 and Lnk/Sh2b3 1n B cells.2012

    • Author(s)
      Iseki M, Takaki S.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] An autoimmune discase-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates T cell differentiation.2012

    • Author(s)
      Mori T, Iwasaki Y, Iseki M, Takaki S.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] An autoimmune disease-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates T cell differentiation.2012

    • Author(s)
      Mori T, Iwasaki Y, Iseki M, Takaki S
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Differentiation mechanism for innate response activator (IRA) B cell induced by LPS.2012

    • Author(s)
      Kudo F, Seki Y, Takaki S
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Characterization of innate IL-5-producing non-T cells in the large intestine regarding responsiveness to IL-33 and IgA production.2012

    • Author(s)
      Yanagibashi T, Ikutani M, Nagai Y, Takaki S, Takatsu K.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Differentiation mechanism for innate response activator (IRA) B cell induced by LPS.2012

    • Author(s)
      Kudo F, Seki Y, Takaki S.
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2012-12-07
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] IgE production is under the control of the Sh2b adaptor protein family, Aps/Sh2b2 and Lnk/Sh2b3 in B cells.2012

    • Author(s)
      Iseki M, Takaki S
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Characterization of innate IL-5-producing non-T cells in the large intestine regarding responsiveness to IL-33 and IgA production.2012

    • Author(s)
      Yanagibashi T, Ikutani M, Nagai Y, Takaki S, Takatsu K
    • Organizer
      第41回日本免疫学会学術集会
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Enhanced hematopoietic differentiation from mouse embryonic stem cells and induced pluripotent stem cells by inhibition of an adaptor protein, Lnk.2011

    • Author(s)
      Tashiro K, Yamaguchi T, Kawabata K, Takaki S, Mizuguchi H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] An autoimmune disease-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates regulatory T and helper T cell development2011

    • Author(s)
      Mori T, Anraku M, Iwasaki Y, Katayama H, Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] An autoimmune disease-associated gene, Lnk/SH2B3 controls signaling of inflammatory cytokines in dendritic cells and regulates regulatory T and helper T cell development2011

    • Author(s)
      Mori T, Anraku M, Iwasaki Y, Katayama H, Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Homeostasis of hematopoietic stem cells regulated by myeloproliferative disease associated gene product Lnk/Sh2b3.2011

    • Author(s)
      Suzuki-Yamazaki N, Yamazaki S, Nakauchi H, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] IgE-specific impairment in humoral immune responses by the absence of Aps/Sh2b2, a member of Lnk/Sh2b adaptor family2011

    • Author(s)
      Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-27
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] CD8+ T cells cause inflammation and atrophy of intestinal villi in the absence of Lnk/Sh2b3, a shared risk factor gene associated with type-1 diabetes and celiac disease2011

    • Author(s)
      Anraku M, Mori T, Katayama H, Hashimoto K, Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Homeostasis of hematopoietic stem cells regulated by myeloproliferative disease associated gene product Lnk/Sh2b32011

    • Author(s)
      Suzuki-Yamazaki N, Yamazaki S, Nakauchi H, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] CD8+ T cells cause inflammation and atrophy of intestinal villi in the absence of Lnk/Sh2b3, a shared risk factor gene associated with type-1 diabetes and celiac disease.2011

    • Author(s)
      Anraku M, Mori T, Katayama H, Hashimoto K, Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Enhanced hematopoietic differentiation from mouse embryonic stem cells and induced pluripotent stem cells by inhibition of an adaptor protein, Lnk2011

    • Author(s)
      Tashiro K, Yamaguchi T, Kawabata K, Takaki S, Mizuguehi H
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-29
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] IgE-specific impairment in humoral immune responses by the absence of Aps/Sh2b2, a member of Lnk/Sh2b adaptor family.2011

    • Author(s)
      Iseki M, Takaki S
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] The major IL-5-producing cells in the intestine and lung are c-kit+CD3e-cells2011

    • Author(s)
      Yanagibashi T, Ikutani M, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      幕張メッセ
    • Year and Date
      2011-11-28
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] The major IL-5-producing cells in the intestine and lung are c-kit+ CD3ecells.2011

    • Author(s)
      Yanagibashi T, Ikutani M, Kouro T, Itakura A, Nagai Y, Takaki S, Takatsu K
    • Organizer
      第40回日本免疫学会学術集会
    • Place of Presentation
      千葉
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Generation of engraftable hematopoietic stem cells from teratomas formed by an injection of induced pluripotent stem cells.2010

    • Author(s)
      Suzuki N, Yamazaki S, Yamaguchi T, Takaki S, Nakauchi H
    • Organizer
      International Society for Stem Cell Research
    • Place of Presentation
      San Francisco, USA
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] The maintenance of gut-associated lymphoid tissues regulated by Lnk/Sh2B3 adaptor, a shared risk factor gene associated with type 1 diabetes and celiac disease.2010

    • Author(s)
      Takaki S
    • Organizer
      The 14th International Congress of Immunology
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Lnk/SH2B3, a gene associated with risk of several autoimmune diseases regulates proliferation and retinoic acid production of dendritic cells.2010

    • Author(s)
      Iwasaki Y, Koyama J, Katayama H, Hamamichi R, Iseki M, Yamamoto K, Takatsu K, Takaki S
    • Organizer
      The 14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] The maintenance of gut-associated lymphoid tissues regulated by Lnk/Sh2B3 adaptor, a shared risk factor gene associated with type 1 diabetes and celiac disease.2010

    • Author(s)
      Katayama H, Iwasaki Y, Fujimoto M, Hamamichi R, Iseki M, Yoshida N, Takatsu K, Takaki S
    • Organizer
      The 14th International Congress of Immunology
    • Place of Presentation
      Kobe, Japan
    • Data Source
      KAKENHI-PROJECT-22590446
  • [Presentation] Regulation of dendritic cell production and function by Lnk/SH2B3, a negative regulator of lymphohematopoiesis.2009

    • Author(s)
      Takaki S.
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20060038
  • [Presentation] Regulation of dendritic cell production and function by Lnk/SH2B3, a negative regulator of lymphohematopoiesis.2009

    • Author(s)
      Takaki S.
    • Organizer
      第39回日本免疫学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-12-02
    • Data Source
      KAKENHI-PROJECT-20057033
  • [Presentation] Dual-functional adaptor Lnk controls lymphohematopoietic cells by regulatingcytokine- and adhesion-dependent signals2007

    • Author(s)
      Takaki, S.
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-18060009
  • [Presentation] Control of Dendritic Cell Production by Lnk/SH2B3 Adaptor Protein, a Negative Regulator of Lymphohematopoiesis2007

    • Author(s)
      Iwasaki Y, Takizawa H, Yamamoto K, Takatsu K, Takaki S
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-16109004
  • [Presentation] Genes involved in Btk-dependent pro-B to pre-B transition, Keystone Symposia2007

    • Author(s)
      Ikutani M, Kouro T, Takaki S, Takatsu K
    • Organizer
      Banff
    • Place of Presentation
      Canada
    • Data Source
      KAKENHI-PROJECT-16109004
  • [Presentation] Control of cell adhesion and migration in B lymphocytes and hematopoietic progenitors by Lnk, a negative regulator of cytokine signaling2007

    • Author(s)
      Takaki S, Iwasaki Y, Kubo C, Takizawa H, Takatsu K
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Data Source
      KAKENHI-PROJECT-16109004
  • [Presentation] Lnk, An Adaptor Protein, Modulates Signals mediated through integrins and cytokine receptors in hematopoietic progenitors2007

    • Author(s)
      Takizawa H, Eto K, Nakauchi H, Takatsu K, Takaki S
    • Organizer
      13th International Congress of Immunology
    • Place of Presentation
      Rio de Janeiro, Brazil
    • Data Source
      KAKENHI-PROJECT-16109004
  • [Presentation] Control of cell adhesion and migration in B lymphocytes and hematopoieticprogenitors by Lnk,a negative regulator of cytokine signaling2007

    • Author(s)
      Takaki, S.
    • Organizer
      第13回 国際免疫学会
    • Place of Presentation
      リオデジャネイロ、ブラジル
    • Data Source
      KAKENHI-PROJECT-18060009
  • [Presentation] Dynamic expression patterns of Lnk, a negative regulatory adaptor in lymphohematopoiesis revealed by generating a GFP knock-in reporter mice2007

    • Author(s)
      Katayama H, Ikutani M, Yoshida N, Takatsu K, Takaki S
    • Organizer
      第37回日本免疫学会学術集会
    • Place of Presentation
      東京
    • Data Source
      KAKENHI-PROJECT-16109004
  • [Presentation] Suppression of cytokine production from group 2 innate lymphoid cells by interferon-γ.

    • Author(s)
      Kudo F, Seki Y, Takaki S.
    • Organizer
      第43回 日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Lnk/Sh2b family adaptor protein Aps/Sh2b2 in B cells contributes to germinal center B cell survival and optimal IgE production in vivo.

    • Author(s)
      Iseki M, Kudo F, Takaki S.
    • Organizer
      第43回 日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] Lnk/Sh2b3 adaptor protein controls cytokine responses of dendritic cells, and regulates the induction of IFN-γ-producing T cells.

    • Author(s)
      Mori T, Iseki M, Takaki S.
    • Organizer
      第43回 日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25293097
  • [Presentation] IgM+ plasma cells contribute to the sufficient production of IgG by secreting IL-10 and IL-13.

    • Author(s)
      Yamazaki N, Takaki S.
    • Organizer
      第43回 日本免疫学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-12-10 – 2014-12-12
    • Data Source
      KAKENHI-PROJECT-25293097
  • 1.  TAKATSU Kiyoshi (10107055)
    # of Collaborated Projects: 11 results
    # of Collaborated Products: 16 results
  • 2.  KARIYONE Ai (50114450)
    # of Collaborated Projects: 6 results
    # of Collaborated Products: 2 results
  • 3.  KINASHI Tatsuo (30202039)
    # of Collaborated Projects: 5 results
    # of Collaborated Products: 0 results
  • 4.  HITOSHI Yasumichi (10222241)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 5.  KATAGIRI Takutya (70126100)
    # of Collaborated Projects: 4 results
    # of Collaborated Products: 0 results
  • 6.  TAMURA Toshiki (40291306)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 7.  UEHARA Shoji (60272499)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 8.  HORIKAWA Keisuke (60313095)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 9.  MELCHERS Friz
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 10.  NAGAI Yoshinori (30431761)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 11.  KOURO Taku (90372424)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 12.  SASAZUKI Takehiko (50014121)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 13.  SHIRASAWA Senji (10253535)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 14.  OKAMURA Takashi (00333790)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 15.  SORIMACHI Noeiko (30217468)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 16.  SUZUKI Harumi (70235985)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 17.  YAMAMOTO Ken (60274528)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 18.  KIKUCHI Yuji (60262078)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 19.  NISITANI Sazuku (10322075)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 20.  ATO Manabu (20392318)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 21.  IKEBE Tadayoshi (20333362)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 22.  Iseki Masanori (30532353)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 3 results
  • 23.  宮崎 純一 (10200156)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 24.  大海 忍 (20160046)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 25.  PERLMUTTER Roger
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 26.  テルホルフート コックス
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 27.  キンケード ポール
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 28.  メルシャーズ フリッツ
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 29.  KINCADE Paul
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 30.  YASUMICHI Hitoshi
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 31.  TERHORS Cox
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 32.  COX Terhorst
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 33.  PAUL Kincade
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 34.  FRITS Melche
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 35.  コックス テルホルスト
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 36.  ポール キンケード
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 37.  フリッツ メルシャーズ
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 38.  SPRINGER Tim
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 39.  TIMOTHY Springer
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 40.  TIMOTHY Spri
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 41.  REGER Perlmu
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 42.  FRIZ Melcher
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
  • 43.  HINO Nobumasa
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 44.  KAWAMURA Yuki I
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 45.  IKUTANI Masashi
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 46.  中内 啓光
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 47.  山崎 奈穂(鈴木奈穂)
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 48.  常山 幸一
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 49.  BURKLY Linda C.
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
  • 50.  土肥 多恵子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 2 results
  • 51.  山下 尋史
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi