NIKI Ichiro 仁木一郎

… Alternative Names

仁木一朗ニキイチロウ

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Researcher Number	10262908
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2005 – 2012: 大分大学, 医学部, 教授 2003: Oita University, School of Medicine, Professor, 医学部, 教授 2002 – 2003: OITA MEDICAL UNIVERSITY, PROFESSOR, 医学部, 教授 2002: 大分医科大学, 教授 2001: 名古屋大学, 大学院・医学研究科, 助教授 1996 – 2001: Nagoya University, Associate Professor, 医学部, 助教授 1995: 名古屋大学, 医学部, 講師
Review Section/Research Field	Principal Investigator Metabolomics / General pharmacology / Metabolomics / Pathological medical chemistry Except Principal Investigator General pharmacology / Kidney internal medicine / General anatomy (including Histology/Embryology) / Pathological medical chemistry
Keywords	Principal Investigator 膵B細胞 / カルモジュリン / 糖尿病 / pancreatic beta cell / プロテインキナーゼ / カルサイクリン / インスリン / カルシウムシグナリング / カルシウム結合蛋白 / シグナル伝達 … More / インスリン分泌 / NO (nitric oxide) / sulphonylureas / insulin / apoptosis / transgenic mouse / calmodulin / type 2 diabetes mellitus / NO / スルホニル尿素 / アポトーシス / トランスジェニックマウス / 2型糖尿病 / intracellular calcium / intracellular traffic / annexin / myosin / protein kinase / secretary granules / insulin release / カルモデュリン / モーター蛋白 / 顆粒運動 / 細胞内カルシウム / 細胞内トラフィック / アネキシン / ミオシン / 分泌顆粒 / isopurine compounds / isoquinolinesulphonamide compounds / cdc2 kinase / cell cycle / protein kinase inhibitor / 分子プローブ / イソプリン化合物 / イソキノリンスルホナミド化合物 / cdc2キナーゼ / 細胞周期 / プロテインキナーゼ阻害剤 / CALCYCLIN / CALMODULIN / DIABETES MELLITUS / INSULIN / PANCREATIC B-CELL / HORMONE SECRETION / CALCIUM-SIGNALLING / CALCIUM-BINDING PROTEINS / 内分泌 / 細胞・組織 / 生体分子 / 薬理学 / 高血糖 / 細胞保護 / L-システムイン / 酸化ストレス / L-システィン / グルタチオン / 硫化水素 / 細胞死 / L-システイン … More Except Principal Investigator calmodulin / eNOS / VEGF / diabetic nephropathy / endothelial injury / ERK / protein kinase C / midkine / apoptosis / アポトーシス / 糖尿病性腎症 / hilar hyalinosis / chemokine / PKC / MAPK / Midkine / nodular lesion / exudative lesion / VGF / caveolin-1 / glucose / phogrin / pancreatic B cells / MIN6 cells / insulin secretion / GFP / 顆粒運動 / MIN6 / 神経型NO合成酵素 / トルブタミド / CaMマウス / カルシウムイオン / インスリン顆粒 / γ-チュブリン / カベオリン-1 / カルモジュリン / グルコース刺激 / フォグリン / B細胞 / MIN6細胞 / インスリン分泌 / 4-OH-TEMPO / culture cells / TEMPO derivatives / scavengers / free radicals / megamitochondria / スカベンジャー / mdm10 / mmml / ミトコンドリア形態制御遺伝子 / coenzymeQ_<10> / acetylated α-tubulin / nocodazole / taxol / 微小管 / フリーラジカルスカベンジャー / 培養細胞 / 酸素ラジカル / TEMPO誘導体 / フリーラジカル / ミトコンドリア巨大化 / Computer simulation / Drug design / Structure-activity relationship / Tertiary structure / Inhibitor / Protein kinase / Intracellular signal transduction / 分子基礎理論 / 活性調節部位 / 有機合成 / 分子設計 / 特異的阻害剤 / コンピューターシュミレーション / 創薬 / 蛋白質立体構造 / 構造活性相関 / 阻害剤 / 蛋白質リン酸化酵素 / 細胞内シグナリング / PROTEIN KINASE CASCADES / CALMODULIN-DEPENDENT PROTEIN KINASE / CALMODULIN / CALCIUM SIGNAL TRANSDUCTION / 活性化メカニズム / カルモデュリンキナーゼV活性化因子 / カルモデュリンキナーゼV / カルモデュリン依存性キナーゼ / プロテインキナーゼカスケード / カルモデュリンキナーゼ / カルモデュリン / カルシウムシグナリング / 3D-structure / NMR / Ca^<2+>-binding proteins / annexinXI / Calcyclin / 高次構造変換 / 細胞内局在 / NMR解析 / アネキシンXI / 高次構造 / 核磁気共鳴法 / カルシウム結合蛋白質 / アネキシン / カルサイクリン / 硫化水素 / 尿細管・間質障害 / バイオマーカー / VEGF-Ainduce / E-selectin / Basigin / microinflammation / NO uncoupling / ベイシジン Less

生体における硫化水素産生が耐糖能に与える影響とその機序の解明Principal Investigator
- Principal Investigator
  
  仁木一郎
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
第3のガスメッセンジャー硫化水素の誘導性産生機序とその役割の解明Principal Investigator
- Principal Investigator
  
  仁木一郎
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
Role of Basigin-VEGF/NO signal in the diabetic nephropathy
- Principal Investigator
  
  YUZAWA Yukio
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
Protection of pancreatic B-cell by the sulphur-containing amino acid L-cysteine and investigation of its underlying mechanismsPrincipal Investigator
- Principal Investigator
  
  NIKI Ichiro
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  Oita University
The establishment of new animal models for diabetic nephropathy (DN) and the development of Midkine-targeted therapy against DN.
- Principal Investigator
  
  YUZAWA Yukio
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Kidney internal medicine
- Research Institution
  Nagoya University
A study on the Intracellular dynamics of insulin granules using a phogrin-GFP fused protein
- Principal Investigator
  
  SENDA Takao
- Project Period (FY)
  2001 – 2003
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  General anatomy (including Histology/Embryology)
- Research Institution
  Fujita Health University
MECHNISMS OF PANCREATIC BETA CELL DEATH BY Ca^<2+>/CALMODULIN; USING TRANSGENIC MICEPrincipal Investigator
- Principal Investigator
  
  NIKI Ichiro
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Metabolomics
- Research Institution
  OITA MEDICAL UNIVERSITY
  Nagoya University
Molecular mechanism of free radical-induced apoptosis
- Principal Investigator
  
  WAKABAYASHI Takashi
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagoya University
Novel calcium signaling pathways in cell cycle regulationsPrincipal Investigator
- Principal Investigator
  
  NIKI Ichiro, 日高弘義
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University
STUDIES ON REGULATING MECHANISMS OF INTRACELLULAR MOVEMENT OF THE INSULIN GRANULESPrincipal Investigator
- Principal Investigator
  
  NIKI Ichiro
- Project Period (FY)
  1997 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  NAGOYA UNIVERSITY
NETWORK OF CALCIUM-BINDING PROTEINS IN THE SIGNAL CASCADEPrincipal Investigator
- Principal Investigator
  
  NIKI Ichiro
- Project Period (FY)
  1995 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General pharmacology
- Research Institution
  NAGOYA UNIVERSITY
Nuclear magnetic resonance studies of calcyclin and annexin XI.
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for international Scientific Research
- Research Institution
  Nagoya University
ELUCIDATION OF THE INTRACELLULAR CALCIUM SIGNAL TRANSDUCTION WITH THE MOLECULAR PHARMACOLOGICAL APPROARCH
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  NAGOYA UNIVERSITY
Molecular basis and generation of new compounds for probing phosphorylation-mediated signaling pathways
- Principal Investigator
  
  HIDAKA Hiroyoshi
- Project Period (FY)
  1994 – 1996
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  General pharmacology
- Research Institution
  Nagoya University

All 2012 2011 2010 2009 2008 2007 2006

All Journal Article Presentation Book

[Book] 薬の散歩道2010
- Author(s)
  仁木一郎
- Total Pages
  177
- Publisher
  メディカル・サイエンス・インターナショナル
- Data Source
  KAKENHI-PROJECT-21591146
[Book] 新時代の糖尿病学(1)日本臨床別冊66巻増刊号3(分担執筆)「膵β細胞のグルコース認識と分泌経路」2008
- Author(s)
  仁木一郎
- Publisher
  日本臨床社
- Data Source
  KAKENHI-PROJECT-19591060
[Book] インスリン分泌とプロテインキナーゼ. 『糖尿病学』(門脇孝、石橋俊、佐倉宏、野田光彦、戸辺一之編)2007
- Author(s)
  仁木一郎
- Publisher
  西村書店
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] 膵B細胞における硫化水素産生と細胞保護作用2012
- Author(s)
  仁木一郎
- Journal Title
  
  日本薬理学会誌
  
  Volume: 139 Pages: 13-16
- NAID
  10030455969
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Protein phosphorylation involved in the gene expression of the hydrogen sulphide producing enzyme cystathionine γ-lyase in the pancreatic β-cell2012
- Author(s)
  Taniguchi S, Kimura T, Umeki T, Kimura Y, Kimura H, Ishii I, Itoh N, Naito Y, Yamamoto H, Niki I
- Journal Title
  
  Mol.Cell.Endocrinol.
  
  Volume: 350 Issue: 1 Pages: 31-38
- DOI
  10.1016/j.mce.2011.11.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146, KAKENHI-PROJECT-22590258, KAKENHI-PROJECT-22590292, KAKENHI-PROJECT-22790255, KAKENHI-PROJECT-23500451, KAKENHI-PROJECT-23659089, KAKENHI-PROJECT-23791039, KAKENHI-PUBLICLY-23117716
[Journal Article] Significance of hydrogen sulfide production in the pancreatic beta cell2011
- Author(s)
  Taniguchi S, Niki I
- Journal Title
  
  J.Pharmacol.Sci
  
  Volume: (in print)
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Rab27a, actin and beta-cell endocytosis2011
- Author(s)
  Kimura T, Niki I
- Journal Title
  
  Endocrine J.
  
  Volume: 58 Pages: 1-6
- NAID
  10029587246
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Rab27a in pancreatic beta-cells, a busy protein in membrane trafficking2011
- Author(s)
  Kimura T, Niki I
- Journal Title
  
  Prog.Biophys.Mol.Biol.
  
  Volume: 107 Issue: 2 Pages: 219-223
- DOI
  10.1016/j.pbiomolbio.2011.06.016
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146, KAKENHI-PROJECT-23791039
[Journal Article] Hydrogen sulphide protects mouse pancreatic β-cells from cell death induced by oxidative stress, but not by endoplasmic reticulum stress2011
- Author(s)
  Taniguchi S, Kang L, Kimura T, Niki I
- Journal Title
  
  Brit.J.Pharmacol
  
  Volume: 162 Pages: 1171-1178
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Significance of Hydrogen Sulfide Production in the Pancreatic .BETA.-Cell2011
- Author(s)
  Taniguchi S, Niki I
- Journal Title
  
  J Pharmacol Sci
  
  Volume: 116 Issue: 1 Pages: 1-5
- DOI
  10.1254/jphs.11R01CP
- NAID
  10029893605
- ISSN
  1347-8613, 1347-8648
- Language
  English
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] インスリン分泌過程研究の変遷2010
- Author(s)
  木村俊秀, 仁木一郎
- Journal Title
  
  Islet Equality、メディカルレビュー社 (印刷中)
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Actin assembly controlled by GDP-Rab27a is essential for endocytosis of the insulin secretory membrane.2010
- Author(s)
  Kimura T, Taniguchi S, Niki I
- Journal Title
  
  Arch.Biochem.Biophys
  
  Volume: 496 Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Glucose-induced translocation of coronin 3 regulates the retrograde transport of the secretory membrane in the pancreatic β-cells2010
- Author(s)
  Kimura T, Taniguchi S, Toya K, Niki I
- Journal Title
  
  Biochem.Biophys.Res.Commun
  
  Volume: 395 Pages: 318-323
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Actin assembly controlled by GDP-Rab27a is essential for endocytosis of the insulin secretory membrane2010
- Author(s)
  Kimura T, Taniguchi S, Niki I
- Journal Title
  
  Archives of Biochemistry and Biophysics 496
  
  Pages: 33-37
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Establishment and characterization of a novel method for evaluating gluconeogenesis using hepatic cell lines, H4IIE and HepG22009
- Author(s)
  Okamoto T, Kanemoto N, Ban T, Sudo T, Nagano K, Niki I
- Journal Title
  
  Archives of Biochemistry and Biophysics 491
  
  Pages: 46-52
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose2009
- Author(s)
  Kaneko Y, Kimura T, Taniguchi S, Souma M, Kojima Y, Kimura Y, Kimura H, Niki I
- Journal Title
  
  FEBS Lett. 583
  
  Pages: 377-82
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] インクレチンによる細胞量の調節2009
- Author(s)
  仁木一郎
- Journal Title
  
  月刊糖尿病「別冊・インクレチン」(稲垣暢也編)、医学出版
  
  Pages: 37-44
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Glucose-induced production of hydrogen sulfide may protect the pancreatic beta-cells from apoptotic cell death by high glucose2009
- Author(s)
  Kaneko Y, Kimura T, Taniguchi S, Souma M, Kojima Y, Kimura Y, Kimura H, Niki I
- Journal Title
  
  FEBS Letters 583
  
  Pages: 377-382
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591146
[Journal Article] Overexpression of Calmodulin in Pancreatic {beta} Cells Induces Diabetic Nephropathy2008
- Author(s)
  Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo S
- Journal Title
  
  Journal of the American Society of Nephrology 19(9)
  
  Pages: 1701-1711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590947
[Journal Article] Radioimmunoscintigraphy of pancreatic cancer in tumor-bearing athymic nude mice using ^<99m>technetium-labeled anti-KL-6/MUC1 antibody2008
- Author(s)
  Matsumura K, Niki I, Tian H, Takuma M, Hongo N, Matsumoto S, Mori M
- Journal Title
  
  Radiation Medicine 26
  
  Pages: 133-139
- NAID
  10024138099
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] Diabetic nephropathy in transgenic mice overexpressing beta cell calmodulin2008
- Author(s)
  Yuzawa Y, Niki I, Kosugi T, Maruyama S, Yoshida F, Takeda M, Tagawa Y, Kaneko Y, Kimura T, Kato N, Yamamoto J, Sato W, Nakagawa T, Matsuo M
- Journal Title
  
  J Am Soc Nephrol 19
  
  Pages: 1701-1711
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] 「膵β細胞のグルコース認識と分泌経路」新時代の糖尿病学(1)日本臨床2008
- Author(s)
  仁木一郎
- Journal Title
  
  日本臨床社 66巻増刊号3
  
  Pages: 145-149
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] The GDP-dependent Rab27a effector coronin 3 controls endocytosis of secretory membrane in insulin-secreting cell lines2008
- Author(s)
  Kimura T, Kaneko Y, Yamada S, Ishihara H, Senda T, Iwamatsu A, Niki I
- Journal Title
  
  J Cell Sci. 121(Pt18)
  
  Pages: 3092-3098
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] 膵β細胞のグルコース認識と分泌経路2008
- Author(s)
  仁木一郎
- Journal Title
  
  日本臨床(別冊) 新時代の糖尿病学1 935
  
  Pages: 143-148
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] 硫化水素とインスリン分泌内分泌・糖尿病科2007
- Author(s)
  金子雪子、木村俊秀、仁木一郎
- Journal Title
  
  科学評論社 25(3)
  
  Pages: 245-249
- Data Source
  KAKENHI-PROJECT-19591060
[Journal Article] Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress ; in vivo and in vitro studies2007
- Author(s)
  Tsunekawa S, Yamamoto N, Tsukamoto K, Itoh Y, Kaneko Y, Kimura T, Ariyoshi Y, Miura Y, Oiso Y, Niki I
- Journal Title
  
  J Endocrinol 193
  
  Pages: 65-74
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] マウス膵β細胞における硫化水素産生酵素のカルシウム依存性発現調節2012
- Author(s)
  谷口繁生、木村俊秀、岡本光弘、仁木一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都府京都市
- Year and Date
  2012-03-15
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] Rab27aとcoronin3の細胞内局在を規定する新規GDP依存性Rab27aエフェクターの同定2012
- Author(s)
  木村俊秀、山岡真美、谷口繁生、仁木一郎
- Organizer
  第85回日本薬理学会年会
- Place of Presentation
  京都府京都市
- Year and Date
  2012-03-16
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] 硫化水素が膵B細胞を保護する分子機序の検討2011
- Author(s)
  谷口繁生、康林、木村俊秀、仁木一郎
- Organizer
  第54回日本糖尿病学会
- Place of Presentation
  北海道札幌市
- Year and Date
  2011-05-20
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] GDP型Rab27aエフェクターによる分子クラスターの形成とエンドサイトーシスの制御2011
- Author(s)
  木村俊秀、山岡真美、谷口繁生、仁木一郎
- Organizer
  第64回日本薬理学会西南部会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] Rab27a-GAP新規結合タンパク質の探索2011
- Author(s)
  山岡真美、木村俊秀、谷口繁生、仁木一郎
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] インスリン顆粒膜のエンドサイトーシスを調節するGDP型Rab27aエフェクターによる分子クラスターの形成2011
- Author(s)
  木村俊秀、山岡真美、谷口繁生、仁木一郎
- Organizer
  第54回日本糖尿病学会
- Place of Presentation
  北海道札幌市
- Year and Date
  2011-05-19
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] The GDP-dependent Rab27a effectorcoronin 3 controls endocytosis of the insulin granule membranes2011
- Author(s)
  Niki I, Kimura T
- Organizer
  Inrternational sympojium 'Computational Physiology of Cardiac Myocytes and Pancreatic β Cells ; Interaction between Energy Metabolism and Membrane Excitability
- Place of Presentation
  Kyoto, Japan.
- Year and Date
  2011-01-30
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] GDP型Rab27a結合タンパク質coronin3の細胞内局在を制御する機構の解析2011
- Author(s)
  木村俊秀、山岡真美、谷口繁生、仁木一郎
- Organizer
  第34回日本分子生物学会年会
- Place of Presentation
  神奈川県横浜市
- Year and Date
  2011-12-15
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] 膵島における硫化水素産生酵素の発現調節の種差について2011
- Author(s)
  谷口繁生、木村俊秀、岡本光弘、仁木一郎
- Organizer
  第64回日本薬理学会西南部会
- Place of Presentation
  福岡県福岡市
- Year and Date
  2011-11-20
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] GDP型Rab27a結合タンパク質 coronin 3によるインスリン顆粒膜のエンドサイトーシス制御機構の解析2010
- Author(s)
  木村俊秀, 谷口繁生, 仁木一郎
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] マウス膵B細胞に対する硫化水素の保護作用2010
- Author(s)
  谷口繁生, 康林, 木村俊秀, 仁木一郎
- Organizer
  第83回日本薬理学会
- Place of Presentation
  大阪
- Year and Date
  2010-03-18
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] Molecular mechanism of secretory membrane endocytosis by the GDP-dependent Rab27a effector coronin 32010
- Author(s)
  Kimura T, Taniguchi S, Niki I
- Organizer
  Asia Islet Biology and Incretin Symposium
- Place of Presentation
  Kyoto, Japan
- Year and Date
  2010-08-01
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] アクチン骨格の制御を介したインスリン顆粒膜のリサイクリング2010
- Author(s)
  木村俊秀、谷口繁生、仁木一郎
- Organizer
  第53回日本糖尿病学会
- Place of Presentation
  岡山
- Year and Date
  2010-05-27
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] インクレチン関連薬への期待とその課題2010
- Author(s)
  仁木一郎
- Organizer
  第48回日本糖尿病学会九州地方会シンポジウム「インスリン関連薬をどう使うか」
- Place of Presentation
  別府
- Year and Date
  2010-10-30
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] 硫化水素によるマウス膵B細胞保護作用の特性について2010
- Author(s)
  谷口繁生、康林、木村俊秀、仁木一郎
- Organizer
  第53回日本糖尿病学会
- Place of Presentation
  岡山
- Year and Date
  2010-05-28
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] 硫化水素による細胞ストレス抑制と膵B細胞保護2009
- Author(s)
  谷口繁生, 康林, 木村俊秀, 仁木一郎
- Organizer
  第62回日本薬理学会西南部会
- Place of Presentation
  愛媛
- Year and Date
  2009-11-27
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] Roles of the GDP-dependent Rab27a effector coronin 3 in actin assembly and endocytosis of the insulin granule membranes2009
- Author(s)
  木村俊秀, 谷口繁生, 原口美帆, 東家一雄, 仁木一郎
- Organizer
  第32回日本分子生物学会年会
- Place of Presentation
  横浜
- Year and Date
  2009-12-10
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] マウス膵島における硫化水素の細胞保護作用2009
- Author(s)
  谷口繁生、金子雪子、木村俊秀、仁木一郎
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-17
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] Roles of the GDP-dependent Rab27a effector coronin 3 in membrane traffic in the pancreatic beta cell2009
- Author(s)
  木村俊秀, 谷口繁生, 東家一雄, 仁木一郎
- Organizer
  45th Annual meeting of European Association for the Study of Diabetes
- Place of Presentation
  Vienna, Austria
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] The Rab27a cycle synchronizes membrane recycling in the pancreatic beta cell. Asia Islet Biology & Incretin Symposium2009
- Author(s)
  仁木一郎, 木村俊秀
- Organizer
  Asia Islet Biology & Incretin Symposium
- Place of Presentation
  Korea
- Year and Date
  2009-08-02
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] インクレチンの何が期待されているのか2009
- Author(s)
  仁木一郎, 木村俊秀, 谷口繁生
- Organizer
  第30回臨床薬理学会シンポジウム「糖尿病薬新薬開発と Clinical/Research Question の解決」
- Place of Presentation
  横浜
- Year and Date
  2009-12-03
- Data Source
  KAKENHI-PROJECT-21591146
[Presentation] GDP型Rab27a結合タンパク質coronin3によるアクチン細胞骨格制御とインスリン顆粒膜のリサイクリング2009
- Author(s)
  木村俊秀、谷口繁生、東家一雄、仁木一郎
- Organizer
  第82回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2009-03-18
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] インクレチンの小胞体ストレス抑制作用による膵B細胞庇護2008
- Author(s)
  仁木一郎、恒川新、木村俊秀、大磯ユタカ
- Organizer
  第2回インクレチン研究会
- Place of Presentation
  大阪
- Year and Date
  2008-04-19
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] GDP型Rab27a結合タンパク質coronin 3によるインスリン顆粒膜のリサイクリング機構の解明2008
- Author(s)
  木村俊秀、山田将護、岩松明彦、仁木一郎
- Organizer
  第81回日本薬理学会
- Place of Presentation
  横浜
- Year and Date
  2008-03-18
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] GDP型Rab27aはcoronin 3と結合しインスリン顆粒膜のエンドサイトーシスを制御する2008
- Author(s)
  木村俊秀、岩松明彦、仁木一郎
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素(H_2S)は膵B細胞を糖毒性から保護する2008
- Author(s)
  仁木一郎
- Organizer
  第81回日本薬理学会年会
- Place of Presentation
  横浜
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素(H2S)は膵B細胞を糖毒性から保護する2008
- Author(s)
  仁木一郎、金子雪子
- Organizer
  第81回日本薬理学会
- Place of Presentation
  (横浜)シンポジウム
- Year and Date
  2008-03-19
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 膵ランゲルハンス氏島における硫化水素産生酵素CSEの発現2008
- Author(s)
  谷口繁生、金子雪子、木村俊秀、仁木一郎
- Organizer
  第60回日本薬理学会西南部会
- Place of Presentation
  米子
- Year and Date
  2008-11-28
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 膵B細胞におけるL-システイン代謝酵素の発現誘導を介した硫化水素産生調節2008
- Author(s)
  谷口繁生、金子雪子、木村俊秀、仁木一郎
- Organizer
  第51回日本糖尿病学会年次学術集会
- Place of Presentation
  東京
- Year and Date
  2008-05-23
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] GDP型Rab27aはcoronin3と結合しインスリン顆粒膜のエンドサイトーシスを制御する2008
- Author(s)
  木村俊秀、山田将護、谷口繁生、仁木一郎
- Organizer
  第31回日本分子生物学会年会
- Place of Presentation
  神戸
- Year and Date
  2008-12-09
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] CSE発現を介した細胞内H2S産生は膵β細胞を保護する2007
- Author(s)
  金子雪子、木村俊秀、木村英雄、仁木一郎
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 「働かせる」から「いたわる」へ・・・インスリン分泌研究の変遷2007
- Author(s)
  仁木一郎
- Organizer
  第1回福岡Islet Biology研究会
- Place of Presentation
  福岡
- Year and Date
  2007-04-13
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素による細胞庇護;膵B細胞に内蔵された自己防衛機構2007
- Author(s)
  仁木一郎
- Organizer
  第4回九州先進糖尿病研究会
- Place of Presentation
  福岡
- Year and Date
  2007-08-18
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素による細胞庇護 ; 膵B細胞に内蔵された自己防衛機構2007
- Author(s)
  仁木一郎
- Organizer
  第4回九州先進糖尿病研究会
- Place of Presentation
  福岡
- Year and Date
  2007-08-18
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] GDP型Rab27a結合タンパク質の同定と機能解析2007
- Author(s)
  木村俊秀、岩松明彦、仁木一郎
- Organizer
  第59回日本薬理学会西南部会
- Place of Presentation
  宮崎
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素産生酵素CSEの膵B細胞における発現調節とその意義2007
- Author(s)
  仁木一郎、金子雪子、木村俊秀
- Organizer
  第59回日本薬理学会西南部会
- Place of Presentation
  宮崎
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] ガス性シグナル分子硫化水素 ; 膵B細胞に内在するブレーキ2007
- Author(s)
  仁木一郎
- Organizer
  第7回Islet Biology研究会
- Place of Presentation
  東京
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 低分子量Gタンパク質Rab27aの膵B細胞における新規標的タンパク質の同定2007
- Author(s)
  木村俊秀、金子雪子、仁木一郎
- Organizer
  第50回日本糖尿病学会年次学術集会
- Place of Presentation
  仙台
- Year and Date
  2007-05-25
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] ガス性シグナル分子硫化水素;膵B細胞に内在するブレーキ2007
- Author(s)
  仁木一郎
- Organizer
  第7回Islet Biology研究会
- Place of Presentation
  東京
- Year and Date
  2007-07-28
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 硫化水素による細胞庇護;膵B細胞に内蔵された自己防衛機構2007
- Author(s)
  仁木一郎
- Organizer
  第59回日本薬理学会西南部会
- Place of Presentation
  宮崎
- Year and Date
  2007-11-22
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 「働かせる」から「いたわる」へ…インスリン分泌研究の変遷2007
- Author(s)
  仁木一郎
- Organizer
  第1回福岡Islet Biology研究会
- Place of Presentation
  福岡
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] L-Cysteine inhibits insulin release through the metabolic production of hydrogen sulfide, a novel gasotransmitter2006
- Author(s)
  Kaneko Y, Kimura T, Kimura H, NikiI
- Organizer
  42nd Annual meeting of European Association for the Study of Diabetes
- Place of Presentation
  Copenhagen, Denmark
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] Possible involvement of a VEGF receptor subtype-dependent mechanism in the pathogenesis of diabetic nephropathy in the beta cell-specific calmodulin overexpressing mice2006
- Author(s)
  Yuzawa Y, Kosugi T, Hayashi H, Maruyama S, Yoshida F, Tagawa Y, Takeda M, Matsuo S, Niki I
- Organizer
  42^<nd> Annual meeting of European Association for the Study of Diabetes
- Place of Presentation
  Copenhagen, Denmark
- Year and Date
  2006-09-15
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] L-Cysteine metabolism and production of hydrogen sulfide, an inhibitory messenger for insulin release2006
- Author(s)
  Niki I
- Organizer
  Seminar at Peninsula Medical School
- Place of Presentation
  Plymouth, England
- Data Source
  KAKENHI-PROJECT-19591060
[Presentation] 「Possible involvement of a VEGF receptor subtype-dependent mechanism in the pathogenesis of diabetic nephropathy in the beta cell-specific calmodulin overexpressing mice2006
- Author(s)
  Yuzawa Y, Kosugi T, Kato T, Yoshida T, Tagawa Y, Takeda M, Sato W, Nakagawa T, Matsuo S, Niki I
- Organizer
  39th ASNAnnual Renal Week Meeting in Renal Week 2006
- Place of Presentation
  San Diego Convention Center、San Diego, California, USA
- Data Source
  KAKENHI-PROJECT-19591060

1. WATANABE Yasuo (10273228)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
2. HIDAKA Hiroyoshi (80100171)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. YUZAWA Yukio (00191479)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
4. MATSUO Seiichi (70190410)

# of Collaborated Projects: 3 results

# of Collaborated Products: 1 results
5. KADOMATSU Kenji (80204519)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
6. KIMURA Toshihide (60404373)

# of Collaborated Projects: 3 results

# of Collaborated Products: 46 results
7. OKAZAKI Katsuo (20252231)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. MIZUTANI Akihiro (30242861)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
9. SENDA Takao (10187875)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
10. TANIGUCHI Shigeki (90392406)

# of Collaborated Projects: 2 results

# of Collaborated Products: 30 results
11. YOKOKURA Hisayuki (90273242)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
12. KANEKO Yukiko (00381038)

# of Collaborated Projects: 1 results

# of Collaborated Products: 13 results
13. HAGIWARA Masatoshi (10208423)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
14. SAKAKIBARA Zinsaku (70080182)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
15. NAITO Yasuhito (80303618)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
16. WAKABAYASHI Takashi (00079998)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
17. YOSHIDA Shonen (70090420)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. HAYAKAWA Tetsuo (80022838)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. HASEGAWA Yoshimi (40288494)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. HIDA Takehiko (20097736)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 黒川剛 (50291406)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
22. SASTRY Mallika

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. LUBIENSKI Michael

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. POTTS Barbara C

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
25. CHAZIN Walter J

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
26. MEIJER Laurent

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
27. LUBIENSKI M

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
28. POTTS Barba

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
29. CHAZIN Walt

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
30. LAURENT Meij

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
31. JERZY Krechn

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
32. ZDZISLAW Wai

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
33. MICHAL Wozni

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

NIKI Ichiro 仁木 一郎

仁木 一朗 ニキ イチロウ

Research Projects

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Co-Researchers

生体における硫化水素産生が耐糖能に与える影響とその機序の解明Principal Investigator

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第3のガスメッセンジャー硫化水素の誘導性産生機序とその役割の解明Principal Investigator

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Role of Basigin-VEGF/NO signal in the diabetic nephropathy

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Protection of pancreatic B-cell by the sulphur-containing amino acid L-cysteine and investigation of its underlying mechanismsPrincipal Investigator

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The establishment of new animal models for diabetic nephropathy (DN) and the development of Midkine-targeted therapy against DN.

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A study on the Intracellular dynamics of insulin granules using a phogrin-GFP fused protein

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MECHNISMS OF PANCREATIC BETA CELL DEATH BY Ca^<2+>/CALMODULIN; USING TRANSGENIC MICEPrincipal Investigator

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Molecular mechanism of free radical-induced apoptosis

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Novel calcium signaling pathways in cell cycle regulationsPrincipal Investigator

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STUDIES ON REGULATING MECHANISMS OF INTRACELLULAR MOVEMENT OF THE INSULIN GRANULESPrincipal Investigator

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NETWORK OF CALCIUM-BINDING PROTEINS IN THE SIGNAL CASCADEPrincipal Investigator

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Nuclear magnetic resonance studies of calcyclin and annexin XI.

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ELUCIDATION OF THE INTRACELLULAR CALCIUM SIGNAL TRANSDUCTION WITH THE MOLECULAR PHARMACOLOGICAL APPROARCH

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NIKI Ichiro 仁木一郎

仁木一朗ニキイチロウ