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Kokubo Hiroki  小久保 博樹

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… Alternative Names

小久保 博樹  コクボ ヒロキ

KOKUBO Hiroki  小久保 博樹

久保田 博樹  クボタ ヒロキ

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Researcher Number 10270480
External Links
Affiliation (Current) 2025: 東都大学, 幕張ヒューマンケア学部, 教授
Affiliation (based on the past Project Information) *help 2022: 広島大学, 医系科学研究科(医), 講師
2019 – 2020: 広島大学, 医系科学研究科(医), 講師
2017 – 2018: 広島大学, 医歯薬保健学研究科(医), 講師
2016: 広島大学, 大学院医歯薬保健学研究院, 講師
2013 – 2016: 広島大学, 医歯薬保健学研究院(医), 講師 … More
2015: 広島大学, 医歯薬保健学研究院, 講師
2015: 広島大学, 大学院医歯薬保健学研究院(医), 講師
2013: 国立遺伝学研究所, 系統生物研究センター, 助教
2013: 広島大学, 医歯薬保健学研究科, 講師
2012: 広島大学, 医歯薬保健学研究院, 講師
2012: 広島大学, 大学院・医歯薬保健学研究院, 講師
2007 – 2011: National Institute of Genetics, 系統生物研究センター, 助教
2008: National Institute of Genetics, 系統生物研究センター, 助教授
2006: National Institute of Genetics, Assistant Professor, 助手
2004 – 2006: 国立遺伝研究所, 助手
2002 – 2006: 国立遺伝学研究所, 系統生物研究センター, 助手
2005: National Institute of Genetics, Genetic strains research center, Assistant Professor, 系統生物学研究センター, 助手
1994: Okazaki National Research Institutes, National Institute for Basic Biology Resea, 基礎生物学研究所, 助手 Less
Review Section/Research Field
Principal Investigator
General anatomy (including histology/embryology) / General anatomy (including Histology/Embryology) / Basic Section 48010:Anatomy-related / Developmental biology
Except Principal Investigator
Developmental biology / Basic Section 53020:Cardiology-related / Basic Section 52050:Embryonic medicine and pediatrics-related / Genome biology / Environmental impact assessment/Environmental policy / Pediatrics … More / General anatomy (including Histology/Embryology) / Embryonic/Neonatal medicine / Cardiovascular medicine / Developmental biology / Biological Sciences Less
Keywords
Principal Investigator
心筋 / ペースメーカー / 分化 / 特殊心筋 / 刺激伝導系 / Notch / 血管 / 血管形成 / Hesr2 / Hesr1 … More / Notchシグナル / 形態形成学 / 発生学 / hesr遺伝子 / Notchシグナル伝達系 … More
Except Principal Investigator
development / マウス / hesr遺伝子 / 発生 / 形態形成 / Notch signaling / Notchシグナル / Mesp2 / オステオプロテゲリン / mouse / morphogenesis / heart / 心臓 / Notch / Hesr2 / Hesr1 / Mesp1 / POU-homeodomain / fkh / POU-M1 / Bm fkh / オステオプロテジェリン / Osteoprotegerin / 大動脈瘤 / 体節時計 / 体節形成 / Hypoxia Inducible Factor / 筋線維芽細胞 / 線維化 / 腹部大動脈瘤 / 動脈瘤 / TRAIL / 炎症 / 川崎病 / 菌体抽出物 / TNF受容体スーパーファミリー / 血管炎 / トランスクリプトーム / トランスクリプトーム解析 / 再生 / ゼブラフィッシュ / CAPs / Diesel particulate matters / particle dosimetry / Ultrafine particles / Molecular biology / health effects / Risk assessment / Nanoparticles / 健康影響評価 / マクロファージ / DNA分析 / DNAファイル / 微小粒子 / ナノテクノロジー / サイトカイン / DNAプロファイル / 粒子毒性 / 大気中濃縮粒子 / ディーゼル粒子 / 粒子動態 / 超微小粒子 / 分子生物学 / 健康影響 / リスク評価 / ナノ粒子 / hesr gene / hesr genes / cardiovasculogenesis / 心血管 / 心臓血管形成 / valve / epithelial-mesenchymal transformation / angiogenesis / pitx2遺伝子 / Pitx2遺伝子 / 機能 / 血管形成 / 遺伝子 / 発現制御 / 血管新生 / segmentation clock / somitogenesis / heart formation / GFP / hesr2 / hesr1 / Notchシグナル系 / Ripply2 / EphA4 / 房室境界 / Notchシグナリング / 心臓形成 / Target genes / Hierarchical gene regulation system / HNF-3 family / Transcription factor SGF-3 / Transcription factor SGF-1 / Silk gland specific transcription / Silk gland differentiation / Scrのカイコホモログ / POU-M1遺伝子 / 転写制御因子 / 組織特異的転写制御 / Bmfkh / ターゲット遺伝子 / 階層的遺伝子制御システム / HNF-3βファミリー / 転写因子SGF-3 / 転写因子SGF-1 / 絹糸腺特異的転写 / 絹糸腺の分化 / 動脈硬化 / Jun Kinase / エイコサペンタエン酸 / Trail / セルトリ細胞 / GDNF / 精子形成 / Soh1h / Dnd1 / Smad2/3 / Smad4 / Nodal / ERK / Smad / Nanos2 / CNOT複合体 / 精子幹細胞 / 性分化 / RNA結合タンパク質 / 生殖細胞 / Notch-YFP / Dll1 / Lunatic Fringe / Lunatic Fring / Pofut1 / キメラ解析 / D111 / 分節境界 / Hes7 / L-fng / 未分節中胚葉 / Tbx6 / 脊椎骨 / Notchシグナ Less
  • Research Projects

    (18 results)
  • Research Products

    (103 results)
  • Co-Researchers

    (37 People)
  •  Study of regulatory mechanisms for differentiation of specialized myocardium leading to pacemakers.Principal Investigator

    • Principal Investigator
      小久保 博樹
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 48010:Anatomy-related
    • Research Institution
      Hiroshima University
  •  外膜層の線維化増進による大動脈瘤拡大予防法開発に向けた基礎的検討

    • Principal Investigator
      バトムンフ ブムデルゲル
    • Project Period (FY)
      2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 53020:Cardiology-related
    • Research Institution
      Hiroshima University
  •  Development of molecular targeted therapy for coronary aneurysm formation in Kawasaki disease

    • Principal Investigator
      Yoshizumi Masao
    • Project Period (FY)
      2018 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 52050:Embryonic medicine and pediatrics-related
    • Research Institution
      Hiroshima University
  •  Analysis of regulating mechanism for development and differentiation of special cardiomyocytesPrincipal Investigator

    • Principal Investigator
      Hiroki Kokubo
    • Project Period (FY)
      2016 – 2018
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Hiroshima University
  •  Elucidation of dedifferentiation mechanism by transcriptome analysis

    • Principal Investigator
      Kikuchi Yutaka
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Genome biology
    • Research Institution
      Hiroshima University
  •  Functional analysis of cardiac precursor cellsPrincipal Investigator

    • Principal Investigator
      Kokubo Hiroki
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including histology/embryology)
    • Research Institution
      Hiroshima University
  •  Molecular mechanism for arteriosclerosis and aortic aneurysm

    • Principal Investigator
      Yoshizumi Masao
    • Project Period (FY)
      2013 – 2015
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Cardiovascular medicine
    • Research Institution
      Hiroshima University
  •  Mechanisms for development and differentiation of cardiomyocytesPrincipal Investigator

    • Principal Investigator
      KOKUBO Hiroki
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Hiroshima University
      National Institute of Genetics
  •  Molecular mechanism underlying sexual development of male germ cells

    • Principal Investigator
      SAGA Yumiko
    • Project Period (FY)
      2009 – 2013
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute of Genetics
  •  Molecular mechanisms of vascular remodeling processPrincipal Investigator

    • Principal Investigator
      KOKUBO Hiroki
    • Project Period (FY)
      2007 – 2008
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      National Institute of Genetics
  •  The mechanism of somite segmentation with periodic patterning

    • Principal Investigator
      SAGA Yumiko
    • Project Period (FY)
      2005 – 2009
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      National Institute of Genetics
  •  HEALTH RISK ASSESSMENT OF ENVIRONMENTAL NANO PARTICLES USING MOLECULAR BIOLOGICAL METHODS

    • Principal Investigator
      ISHIHARA Yoko
    • Project Period (FY)
      2004 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Environmental impact assessment/Environmental policy
    • Research Institution
      KURUME UNIVERSITY
      Tokyo Women's Medical University
  •  心臓血管形成における新規のNotchシグナル伝達系標的遺伝子群hesrの機能解析Principal Investigator

    • Principal Investigator
      小久保 博樹
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Young Scientists (B)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute of Genetics
  •  Analysis for vasculogenesis using genetic engineering mice

    • Principal Investigator
      NAKAZAWA Makoto
    • Project Period (FY)
      2003 – 2005
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Research Field
      Embryonic/Neonatal medicine
    • Research Institution
      Tokyo Women's Medical University
  •  Analysis of molecular mechanism in cardiovasculogenesis by Notch signaling gene manipulation

    • Principal Investigator
      TOMIMATSU Hirofumi
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General anatomy (including Histology/Embryology)
    • Research Institution
      Tokyo Women's Medical University
  •  Function analysis of Notch signaling in cardiogenesis

    • Principal Investigator
      MIYAGAWA Sachiko
    • Project Period (FY)
      2003 – 2004
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Pediatrics
    • Research Institution
      Tokyo Women's Medical University
  •  Molecular bases underlying cardiogenesis and somitogenesis of mesodermal cells

    • Principal Investigator
      SAGA Yumiko
    • Project Period (FY)
      2002 – 2006
    • Research Category
      Grant-in-Aid for Scientific Research (S)
    • Research Field
      Developmental biology
    • Research Institution
      National Institute of Genetics
  •  Hierarchical Gene Regulation System in the Silk Gland

    • Principal Investigator
      SUZUKI Yoshiaki
    • Project Period (FY)
      1993 – 1994
    • Research Category
      Grant-in-Aid for General Scientific Research (B)
    • Research Field
      Developmental biology
    • Research Institution
      Okazaki National Research Institutes

All 2020 2019 2018 2017 2016 2015 2014 2013 2012 2011 2010 2008 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

  • [Book] 細胞工学 11月号 心臓構造生物学:Heart ができるまで 心臓形成とNotchシグナル2014

    • Author(s)
      小久保博樹
    • Total Pages
      7
    • Publisher
      学研メディカル秀潤社
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Book] 遺伝子図鑑2013

    • Author(s)
      斉藤成也、荒木弘之、角谷徹仁、小林武彦、高野敏行、明石裕、浅岡美穂、浅川和秀、飯田哲史、池尾一穂、池村淑道、一柳健司、伊東啓、井ノ上逸朗、岩里琢治、上田龍、榎本和生、小笠原理、長田直樹、桂勲、神沼英里、川上浩一、川崎能彦、小久保博樹 他
    • Total Pages
      263
    • Publisher
      悠書館
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Book] ノックアウトマウスを作製しよう (Medical Bio 5 月号82-88)2008

    • Author(s)
      小久保博樹
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Journal Article] Disruption of Osteoprotegerin has complex effects on medial destruction and adventitial fibrosis during mouse abdominal aortic aneurysm formation.2020

    • Author(s)
      Bumdelger B, Otani M, Karasaki K, Sakai C, Ishida M, Kokubo H, Yoshizumi M
    • Journal Title

      PLoS One

      Volume: 15 Issue: 7 Pages: e0235553-e0235553

    • DOI

      10.1371/journal.pone.0235553

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-18K08038, KAKENHI-PROJECT-20K08405, KAKENHI-PROJECT-18K07878
  • [Journal Article] Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites2019

    • Author(s)
      Noguchi Yu-taro、Nakamura Miki、Hino Nobumasa、Nogami Jumpei、Tsuji Sayaka、Sato Takahiko、Zhang Lidan、Tsujikawa Kazutake、Tanaka Toru、Izawa Kohei、Okada Yoshiaki、Doi Takefumi、Kokubo Hiroki、Harada Akihito、Uezumi Akiyoshi、Gessler Manfred、Ohkawa Yasuyuki、Fukada So-ichiro
    • Journal Title

      Development

      Volume: 146 Issue: 4 Pages: 163618-163618

    • DOI

      10.1242/dev.163618

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-18K19403, KAKENHI-PUBLICLY-18H04802, KAKENHI-PROJECT-16H03262, KAKENHI-PROJECT-17H03608, KAKENHI-PROJECT-17K19356, KAKENHI-PROJECT-17K19487, KAKENHI-PROJECT-16K08443
  • [Journal Article] Sfrp5 identifies murine cardiac progenitors for all myocardial structures except for the right ventricle.2017

    • Author(s)
      Fujii, M., Sakaguchi, A., Kamata, R., Nagao, M., Kikuchi, Y., Evans, S.M., Yoshizumi M., Shimono, A., Saga, Y., and Kokubo, H.
    • Journal Title

      Nature Communications

      Volume: 8 Issue: 1 Pages: 14664-14664

    • DOI

      10.1038/ncomms14664

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26430185, KAKENHI-PROJECT-16K08443
  • [Journal Article] The SGLT2 Inhibitor Luseogliflozin Rapidly Normalizes Aortic mRNA Levels of Inflammation-Related but Not Lipid-Metabolism-Related Genes and Suppresses Atherosclerosis in Diabetic ApoE KO Mice.2017

    • Author(s)
      Yusuke Nakatsu, Hiroki Kokubo, Batmunkh Bumdelger, Masao Yoshizumi, Takeshi Yamamotoya, Yasuka Matsunaga, Koji Ueda, Yuki Inoue, Masa-Ki Inoue, Midori Fujishiro, Akifumi Kushiyama, Hiraku Ono, Hideyuki Sakoda, and Tomoichiro Asano
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 18(8) Issue: 8 Pages: 1704-1717

    • DOI

      10.3390/ijms18081704

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-16K08443, KAKENHI-PROJECT-16K09784, KAKENHI-PROJECT-16K09791, KAKENHI-PROJECT-17K16150, KAKENHI-PROJECT-16J09463, KAKENHI-PROJECT-15K09398
  • [Journal Article] Transcriptomic analyses of Hand2 transgenic embryos.2016

    • Author(s)
      Funato N, Kokubo H, Saga Y.
    • Journal Title

      Genom Data.

      Volume: 9 Pages: 60-62

    • DOI

      10.1016/j.gdata.2016.06.015

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11004, KAKENHI-PROJECT-16K08443
  • [Journal Article] Dazl is a target RNA suppressed by mammalian NANOS2 in sexually differentiating male germ cells2016

    • Author(s)
      Yuzuru Kato, Takeo Katsuki, Hiroki Kokubo, Aki Masuda, Yumiko Saga
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 1-11

    • DOI

      10.1038/ncomms11272

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PUBLICLY-26114512, KAKENHI-PROJECT-25460244, KAKENHI-PLANNED-25112002, KAKENHI-PROJECT-26251025, KAKENHI-ORGANIZER-25112001
  • [Journal Article] EPA Prevents the Development of Abdominal Aortic Aneurysms through Gpr-120/Ffar-4.2016

    • Author(s)
      Kamata R, Bumdelger B, Kokubo H, Fujii M, Yoshimura K, Ishida T, Ishida M, Yoshizumi M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 10 Pages: 0165132-0165146

    • DOI

      10.1371/journal.pone.0165132

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461852, KAKENHI-PROJECT-16K08443
  • [Journal Article] The Transcription Factor Hand1 is Involved In Runx2-Ihh-Regulated Endochondral Ossification.2016

    • Author(s)
      Laurie LE, Kokubo H, Nakamura M, Saga Y, Funato N.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 2 Pages: 150263-150273

    • DOI

      10.1371/journal.pone.0150263

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11004, KAKENHI-PROJECT-25460244, KAKENHI-PROJECT-25670774
  • [Journal Article] Osteoprotegerin Prevents Development of Abdominal Aortic Aneurysms.2016

    • Author(s)
      Bumdelger B, Kokubo H, Kamata R, Fujii M, Yoshimura K, Aoki H, Orita Y, Ishida T, Ohtaki M, Nagao M, Ishida M, Yoshizumi M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 1 Pages: 147088-147107

    • DOI

      10.1371/journal.pone.0147088

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25460244, KAKENHI-PROJECT-25461130
  • [Journal Article] Specification of jaw identity by the Hand2 transcription factor.2016

    • Author(s)
      Funato N, Kokubo H, Nakamura M, Yanagisawa H, Saga Y.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28405-28405

    • DOI

      10.1038/srep28405

    • NAID

      120007135331

    • Peer Reviewed / Acknowledgement Compliant / Open Access
    • Data Source
      KAKENHI-PROJECT-15K11004, KAKENHI-PROJECT-16K08443
  • [Journal Article] Evidence of Notch-Hesr-Nrf2 Axis in Muscle Stem Cells, but Absence of Nrf2 Has No Effect on Their Quiescent and Undifferentiated Stat2015

    • Author(s)
      Yamaguchi M, Murakami S, Yoneda T, Nakamura M, Zhang L, Uezumi A, Fukuda S, Kokubo H, Tsujikawa K, Fukada S
    • Journal Title

      PLoS One

      Volume: 10(9) Issue: 9 Pages: 138517-138531

    • DOI

      10.1371/journal.pone.0138517

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-15K12675, KAKENHI-PROJECT-26860041, KAKENHI-PROJECT-25460244, KAKENHI-PROJECT-25702044
  • [Journal Article] Hesr2 knockout mice develop aortic valve disease with advancing age2013

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Nakashima Y, Kume T, Yoshizumi M, Nakanishi T, Saga Y.
    • Journal Title

      Arterioscler Thromb Vascular Biology

      Volume: 33 Issue: 3 Pages: 84-92

    • DOI

      10.1161/atvbaha.112.300573

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590183, KAKENHI-PROJECT-22590829, KAKENHI-PROJECT-25462147
  • [Journal Article] Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms.2013

    • Author(s)
      Bumdelger B, Kokubo H, Kamata R, Fujii M, Ishida M, Ishida T, Yoshizumi M.
    • Journal Title

      Hiroshima J Med Sci.

      Volume: 62 Pages: 63-67

    • NAID

      120005396042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25461130
  • [Journal Article] Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms.2013

    • Author(s)
      Bumdelger B., Kokubo H., Kamata R., Fujii M., Ishida M., Ishida T., Yoshizumi M..
    • Journal Title

      Hiroshima Journal of Medical Science

      Volume: 62 Pages: 63-63

    • NAID

      120005396042

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Journal Article] Hesr2 knockout mice develop aortic valve disease with advancing age2013

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Nakashima Y, Kume T, Yoshizumi M, Nakanishi T,Saga Y
    • Journal Title

      Arterioscler.Thromb. Vasc. Biol

      Volume: 33

    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] Ectopic retinoic acid signaling affects outflow tract cushion development through suppression of the myocardial Tbx2-Tgfβ2 pathway2012

    • Author(s)
      Sakabe M, Kokubo H, Nakajima Y, Saga Y
    • Journal Title

      Development

      Volume: 139 Pages: 385-95

    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cellnumbers2011

    • Author(s)
      Fukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K,Takeda S, Yamamoto H.
    • Journal Title

      Development.

      Volume: 138 Pages: 4609-19

    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] (MamL1)/Mastermind-like 3 (MamL3) are essential for Notch signaling in vivo2011

    • Author(s)
      Oyama T, Harigaya K, Sasaki N, Okamura Y, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M
    • Journal Title

      Mastermind-like1

      Volume: 138 Issue: 23 Pages: 5235-5246

    • DOI

      10.1242/dev.062802

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21790531, KAKENHI-PROJECT-22500286, KAKENHI-PROJECT-22590183
  • [Journal Article] Mastermind-like 1 (MamL1) and mastermind-like 3 (MamL3) are essential for Notch signaling in vivo.2011

    • Author(s)
      Oyama T, Harigaya K, Sasaki N, OkamuraY, Kokubo H, Saga Y, Hozumi K, Suganami A, Tamura Y, Nagase T, Koga H, Nishimura M, Sakamoto R, Sato M, Yoshida N, Kitagawa M.
    • Journal Title

      Development

      Volume: 138 Pages: 5235-46

    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] Hesr1 and Hesr3 are essential to generate undifferentiated quiescent satellite cells and to maintain satellite cell numbers2011

    • Author(s)
      F ukada S, Yamaguchi M, Kokubo H, Ogawa R, Uezumi A, Yoneda T, Matev MM, Motohashi N, Ito T, Zolkiewska A, Johnson RL, Saga Y, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H
    • Journal Title

      Development

      Volume: 138 Issue: 21 Pages: 4609-4619

    • DOI

      10.1242/dev.067165

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-21300149, KAKENHI-PROJECT-21790884, KAKENHI-PROJECT-22590183
  • [Journal Article] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium2010

    • Author(s)
      Asai, R., Kokubo, H., et al
    • Journal Title

      Development

      Volume: 137 Pages: 3823-3833

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] Endothelin type-A receptor expression defines a distinct subpopulation withinthe first heart field contributing to chamber myocardium2010

    • Author(s)
      Asai R, Kurihara Y, Fujisawa K, Sato T, Kawamura Y, Kokubo H, Tonami K, Nishiyama K, Uchijima Y, Miyagawa-Tomita S, Kurihara H
    • Journal Title

      Development

      Volume: 137 Pages: 3823-3833

    • Data Source
      KAKENHI-PROJECT-22590183
  • [Journal Article] Hesr1 and Hesr2 may act as early effectors of Notch signaling in the developing cochlea2008

    • Author(s)
      Hayashi T, Kokubo H , Hartman BH, Ray CA, Reh TA, Bermingham-McDonogh O
    • Journal Title

      Developmental Biology 316

      Pages: 87-99

    • Data Source
      KAKENHI-PROJECT-19590183
  • [Journal Article] 心房と心室の境界はどのように作られるのか2008

    • Author(s)
      小久保博樹
    • Journal Title

      Medical Bio 5 月号

      Pages: 16-17

    • Data Source
      KAKENHI-PROJECT-19590183
  • [Journal Article] Hesrl/Hey1 and Hesr2/Hey2 regulate atrial-ventricular boundary formation in the developing heart through the repression of Tbx2.2007

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Saga Y
    • Journal Title

      Development 134

      Pages: 747-755

    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Hesr1/Hey1 and Hesr2/Hey2 regulate atrial-ventricular boundary formation in the developing heart through the repression of Tbx2.2007

    • Author(s)
      Kokubo H. et al.
    • Journal Title

      Development 134

      Pages: 747-755

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Activation of Notchl signaling in cardiogenic mesoderm induce deformed heart morphogenesis2006

    • Author(s)
      Watanabe U, Kokubo H, et al.
    • Journal Title

      Development 133

      Pages: 1625-1634

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Activation of Notch1 signaling in cardiogenic mesoderm induces abnormal heart morphogenesis in mouse.2006

    • Author(s)
      Watanabe Y, Kokubo H, et al.
    • Journal Title

      Development 133

      Pages: 1625-1634

    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Activation of Notch1 signaling in cardiogenic mesoderm induces deformed heart morphogenesis2006

    • Author(s)
      Watanabe U, Kokubo H, et al.
    • Journal Title

      Development 133

      Pages: 1625-1634

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] hesr, a mediator of the Notch signaling in heart and vessel development2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Trends in Cardiovascular Medicine 15(5)

      Pages: 190-194

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system2005

    • Author(s)
      Kokubo H, Miyagawa, Tomita S, et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] Hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation.2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Dev Biol 278(2)

      Pages: 301-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] Hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Developmental Biology 278(2)

      Pages: 301-309

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591139
  • [Journal Article] Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system2005

    • Author(s)
      Kokubo.H., Miyagawa-Tomita, S., Nakazawa, Yumiko Saga, Johnson, R.L.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Data Source
      KAKENHI-PROJECT-15770148
  • [Journal Article] Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system2005

    • Author(s)
      Kokubo H. et al.
    • Journal Title

      Dev.Biol. 278

      Pages: 301-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation.2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Dev Biol 278(2)

      Pages: 301-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591139
  • [Journal Article] hesr, a mediator of the Notch signaling in heart and vessel development2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Trends Cardiovasc Med 15(5)

      Pages: 190-194

    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] hesr, a mediator of the Notch signaling in heart and vessel development2005

    • Author(s)
      Kokubo H, Miyagawa, Tomita S, et al.
    • Journal Title

      Trends in Cardiovascular Medicine 15(5)

      Pages: 190-194

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Saga Y, Johnson RL.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Hesr1 and hesr2 are redundantly required for cardiac chamber formation and arterial formation2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Data Source
      KAKENHI-PROJECT-15591139
  • [Journal Article] Mouse hesr1 and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular system2005

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Mouse hesrl and hesr2 genes are redundantly required to mediate Notch signaling in the developing cardiovascular2005

    • Author(s)
      Kokubo H. et al.
    • Journal Title

      Developmental Biology 278

      Pages: 301-309

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circ Res 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.2004

    • Author(s)
      Kokubo H. et al.
    • Journal Title

      Circ Res. 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality2004

    • Author(s)
      Kokubo H, Miygawa, Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15390335
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15591139
  • [Journal Article] Targeted disruption of hesr2 results in atrioventricular valve2004

    • Author(s)
      Kokubo H. et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] Targeted disruption of hesr2 results atrio-ventricular valve anomalies, leading to cardiac dysfunction and perinatal lethality.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circ Res 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(欧文)」より
    • Data Source
      KAKENHI-PROJECT-15591139
  • [Journal Article] Targeted disruption of hesr2 Results in atrioventricular valve anomalies that lead to heart dysfunction2004

    • Author(s)
      Kokubo, H., Miyagawa-Tomita, S., Tomimatsu, H., Nakashima, Y., Nakazawa, M., Saga, Y., Johnson, R.L.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Data Source
      KAKENHI-PROJECT-15770148
  • [Journal Article] Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to dysfunction2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] マウスの心電図計測方法-生後5日目のbabyからadultまでー2004

    • Author(s)
      岩崎淳一, 宮川-富田幸子, 森善樹, 中澤誠, 富沢康子, 遠藤真弘, 小久保博樹
    • Journal Title

      呼吸と循環 52

      Pages: 203-206

    • Data Source
      KAKENHI-PROJECT-15770148
  • [Journal Article] Nkd1, a Wnt antagonist, exhibits oscillatory gene expression in the PSM under control of Notch signaling2004

    • Author(s)
      Ishikawa A., Kitajima A., Takahashi Y., Kokubo H., Kanno J., Inoue T., Saga, Y.
    • Journal Title

      Mechanisms of Development 121

      Pages: 1443-1453

    • Data Source
      KAKENHI-PROJECT-15770148
  • [Journal Article] Targeted disruption of hesr2 results in atrioventricular valve anomalies that lead to heart dysfunction.2004

    • Author(s)
      Kokubo H, Miyagawa-Tomita S. et al.
    • Journal Title

      Circulation Research 95

      Pages: 540-547

    • Data Source
      KAKENHI-PROJECT-14104024
  • [Journal Article] 心血管形成におけるhesr遺伝子の機能解析2003

    • Author(s)
      小久保博樹, 宮川-富田幸子, 冨松宏文ら
    • Journal Title

      第26回日本分子生物学会

      Pages: 883-883

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590175
  • [Journal Article] Function analysis of hesr genes in cardiovascular development2003

    • Author(s)
      Kokubo H, Miyagawa-Tomita S, Tomimatsu H, et al.
    • Journal Title

      Weinstein Cardiovascular Development Conference

      Pages: 102-102

    • Description
      「研究成果報告書概要(和文)」より
    • Data Source
      KAKENHI-PROJECT-15590175
  • [Presentation] 心臓における刺激伝導系前駆細胞の系譜解析2019

    • Author(s)
      坂口あかね、小久保博樹、安島理恵子、相賀裕美子
    • Organizer
      第124回日本解剖学会総会 シンポジウム “血管研究のイノベーション:構成細胞の起源と形成メカニズムを考える”
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] CaCl2誘導性マウス腹部大動脈瘤モデルの発展性 : Osteoprotegerin-KOマウスを用いた検討2019

    • Author(s)
      唐崎 航平 , Batmunkh Bumdelger, 鎌田 諒 , 小久保 博樹 , 石田 万里 , 吉栖 正生
    • Organizer
      第 2回血管炎病因病態研究会
    • Data Source
      KAKENHI-PROJECT-18K07878
  • [Presentation] Fate mapping of two types of cardiac progenitor cells2018

    • Author(s)
      Hiroki Kokubo, Masayuki Fuiji, and Masao Yoshizumi
    • Organizer
      Weinstein Cardiovascular development and regeneration conference
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] 心臓における刺激伝導系前駆細胞の系譜解析2018

    • Author(s)
      坂口あかね、小久保博樹、安島理恵子、相賀裕美子
    • Organizer
      第72回日本解剖学会中国・四国支部学術集会
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] EPAはJNKシグナル伝達経路の制御を通して腹部大動脈瘤の増悪を抑制する2018

    • Author(s)
      唐崎航平、Batmunkh Bumdelger、小久保博樹、吉栖正生
    • Organizer
      第 59 回日本脈管学会総会
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] 心臓前駆細胞から見た心臓形成 ― 冠状動静脈から刺激伝導系まで2018

    • Author(s)
      小久保博樹、吉栖 正生
    • Organizer
      第 59 回日本脈管学会総会 シンポジウム「発生学から見た心肺・血管・リンパ管学」
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Identification of cardiac progenitors for all cardial structure except for the Right ventricle2017

    • Author(s)
      Masayuki Fujii, Akane Sakaguchi, Masao Yoshizumi, Yumiko Saga, Hiroki Kokubo
    • Organizer
      日本解剖学会
    • Place of Presentation
      長崎
    • Year and Date
      2017-03-28
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Identification of cardiac progenitors for the outflow tract, the left ventricle, the atria, and the sinus venosus2017

    • Author(s)
      Hiroki Kokubo, Masayuki Fujii, Akane Sakaguchi, Yumiko Saga, Masao Yoshizumi
    • Organizer
      分子生物学会
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Osteoprotegerin prevents from aortic aneurysm development2017

    • Author(s)
      Bumdelger Batmunkh, Hiroki Kokubo, Masao Yoshizumi
    • Organizer
      動脈硬化学会
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Novel cardiac progenitors for all components of the heart except for the right ventricle2017

    • Author(s)
      Hiroki Kokubo, Masayuki Fujii, Akane Sakaguchi, Yumiko Saga, Masao Yoshizumi
    • Organizer
      Takao Symposium
    • Invited / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] 右心室以外に寄与する新たな心臓前駆細胞の同定2017

    • Author(s)
      小久保博樹
    • Organizer
      CVMW2017
    • Invited
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] EPA attenuates the progression of Abdominal Aortic Aneurysms2017

    • Author(s)
      Ryo Kamata、Hiroki Kokubo、Batmunkh Bumdelger、Masao Yoshizumi
    • Organizer
      日本循環器学会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] 右心室以外の心筋へと寄与する新たな心筋前駆細胞の同定2017

    • Author(s)
      藤井雅行、吉栖正生、小久保博樹
    • Organizer
      小児循環器学会
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Identification of cardiac progenitors for the outflow tract, the left ventricle, atria, and the sinus venosus2017

    • Author(s)
      Masayuki Fujii, Akane Sakaguchi, Masao Yoshizumi, Yumiko Saga, Hiroki Kokubo
    • Organizer
      日本循環器学会
    • Place of Presentation
      金沢
    • Year and Date
      2017-03-17
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] EPAは腹部大動脈瘤を抑制する2016

    • Author(s)
      鎌田諒、小久保博樹、Batmunkh Bumdelger、吉栖正生
    • Organizer
      日本脈管学会
    • Place of Presentation
      奈良
    • Year and Date
      2016-10-13
    • Data Source
      KAKENHI-PROJECT-16K08443
  • [Presentation] Identification of early progenitors for the sinus venosus in heart development2015

    • Author(s)
      藤井雅行、坂口あかね、相賀裕美子、小久保博樹
    • Organizer
      分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2015-12-01
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Presentation] 腹部大動脈瘤に於けるOsteoprotegerin の役割2015

    • Author(s)
      鎌田諒、小久保博樹、Batmunkh Bumdelger、吉栖正生
    • Organizer
      脈管学会
    • Place of Presentation
      東京
    • Year and Date
      2015-10-29
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Presentation] 腹部大動脈瘤に於ける骨形成因子の抑制的役割2015

    • Author(s)
      鎌田諒、小久保博樹、Batmunkh Bumdelger、吉栖正生
    • Organizer
      大動脈分子病態研究会
    • Place of Presentation
      久留米
    • Year and Date
      2015-08-20
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Presentation] 腹部大動脈瘤の弾性繊維変性における骨形成因子の役割2015

    • Author(s)
      鎌田諒、小久保博樹、Batmunkh Bumdelger、吉栖正生
    • Organizer
      循環器学会
    • Place of Presentation
      広島
    • Year and Date
      2015-11-28
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Presentation] Osteoprotegerinの大動脈瘤形成に果たす役割2013

    • Author(s)
      小久保博樹
    • Organizer
      大動脈分子病態研究会
    • Place of Presentation
      久留米
    • Data Source
      KAKENHI-PROJECT-25460244
  • [Presentation] 先天性心疾患から成人性心疾患まで2012

    • Author(s)
      小久保博樹
    • Organizer
      心臓発生研究会(日本小児心臓学会)
    • Place of Presentation
      福島
    • Invited
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] 先天性心疾患から成人性心疾患まで2012

    • Author(s)
      小久保 博樹
    • Organizer
      心臓発生研究会(日本小児心臓学会)
    • Place of Presentation
      福島
    • Year and Date
      2012-10-19
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] 静脈洞から左心室に寄与する新たな細胞系譜2011

    • Author(s)
      小久保博樹
    • Organizer
      小児循環器学会(心臓血管発生研究会)
    • Place of Presentation
      福島
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] 静脈洞から左心室に寄与する新たな細胞系譜2011

    • Author(s)
      小久保 博樹, 坂口あかね、 相賀裕美子
    • Organizer
      小児循環器学会
    • Place of Presentation
      福島
    • Year and Date
      2011-10-08
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] T-box transcription factor Tbx2 is a key factor in the pathogenesis of congenital heart disease including transposition of great arteries2010

    • Author(s)
      Sakabe, M., Kokubo H. et al
    • Organizer
      日本分子生物・生化学合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] Endothelin type-A receptor expression defines a distinct subpopulation within the first heart field contributing to chamber myocardium2010

    • Author(s)
      Asai, R. Kokubo, H. et al
    • Organizer
      日本分子生物・生化学合同学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Data Source
      KAKENHI-PROJECT-22590183
  • [Presentation] Hesr2 遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹、富田ー宮川幸子、中嶌八隅、中西敏雄、相賀裕美子
    • Organizer
      心筋生研研究会
    • Place of Presentation
      三重
    • Year and Date
      2008-11-28
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2 遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹、富田ー宮川幸子、中嶌八隅、中西敏雄、相賀裕美子
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Year and Date
      2008-07-05
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2 disrupted mice develop stenosis and regurgitation as a result of sclerotic degeneration of the aortic valve with advancing age2008

    • Author(s)
      小久保博樹、富田ー宮川幸子、中嶌八隅、中西敏雄、相賀裕美子
    • Organizer
      分子生物学会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-10
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹
    • Organizer
      心筋生研研究会
    • Place of Presentation
      三重
    • Year and Date
      2008-11-28
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹
    • Organizer
      心臓血管発生研究会
    • Place of Presentation
      福島
    • Year and Date
      2008-07-05
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2 disrupted mice develop dysfunction of semilunar valve with the age2008

    • Author(s)
      小久保博樹、富田ー宮川幸子、中嶌八隅、中西敏雄、相賀裕美子
    • Organizer
      日本循環器学会
    • Place of Presentation
      福岡
    • Year and Date
      2008-03-28
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2 遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹、富田ー宮川幸子、中嶌八隅、中西敏雄、相賀裕美子
    • Organizer
      日本小児循環器学会
    • Place of Presentation
      福島
    • Year and Date
      2008-07-03
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Hesr2 disrupted mice develop stenosis and regurgitation as a result of sclerotic degeneration of the aortic valve with advancing age2008

    • Author(s)
      Hiroki, Kokubo
    • Organizer
      BMB2008
    • Place of Presentation
      神戸
    • Data Source
      KAKENHI-PROJECT-17082010
  • [Presentation] Hesr2遺伝子欠損マウスは大動脈弁石灰化を引き起こす2008

    • Author(s)
      小久保博樹
    • Organizer
      日本小児循環器学会
    • Place of Presentation
      福島
    • Year and Date
      2008-07-03
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] 心房と心室の境界領域形成におけるHesrの役割2007

    • Author(s)
      小久保博樹
    • Organizer
      第30回日本分子生物学会、第80回日本生化学会
    • Place of Presentation
      横浜
    • Data Source
      KAKENHI-PROJECT-17082010
  • [Presentation] 心房と心室の境界領域形成におけるHesr の役割2007

    • Author(s)
      小久保博樹、富田ー宮川幸子、相賀裕美子
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-06
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] 心房と心室の境界領域形成におけるHesrの役割2007

    • Author(s)
      小久保博樹
    • Organizer
      日本分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-06
    • Data Source
      KAKENHI-PROJECT-19590183
  • [Presentation] Induction of Timp1 in smooth muscle cells during development of abdominal aortic aneurysms.

    • Author(s)
      Bumdelger B, Kokubo H, Kamata R, Fujii M, Ishida M, Ishida T, Yoshizumi M.
    • Organizer
      International Vascular Biology Meeting 2014
    • Place of Presentation
      Kyoto
    • Data Source
      KAKENHI-PROJECT-25461130
  • [Presentation] 大動脈瘤形成における血管平滑筋細胞による

    • Author(s)
      小久保博樹
    • Organizer
      脈管学会
    • Place of Presentation
      岡山県 倉敷市
    • Year and Date
      2014-10-30 – 2014-11-01
    • Data Source
      KAKENHI-PROJECT-25460244
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  • 2.  TOMITA Sachiko (40231451)
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    # of Collaborated Products: 21 results
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  • 14.  UENO Kohji (10143504)
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  • 17.  HAGIWARA Hiromi (90189465)
    # of Collaborated Projects: 1 results
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    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 19.  Machida Masayuki (30358006)
    # of Collaborated Projects: 1 results
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  • 20.  坂田 律 (60258423)
    # of Collaborated Projects: 1 results
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  • 21.  藤田 裕規 (10330797)
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    # of Collaborated Products: 0 results
  • 22.  穂積 俊矢 (10597222)
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  • 24.  高橋 啓 (80216712)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 0 results
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    # of Collaborated Projects: 1 results
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  • 27.  NISHIMURA Motoi
    # of Collaborated Projects: 0 results
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    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results
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    # of Collaborated Products: 2 results
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    # of Collaborated Projects: 0 results
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    # of Collaborated Projects: 0 results
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    # of Collaborated Products: 2 results
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