kikuti seiji 菊地誠志

… Alternative Names

KIKUCHI S. 菊地誠志

KIKUCHI Seiji 菊地誠志

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Researcher Number	10271660
Other IDs
External Links
Affiliation (Current)	2025: 独立行政法人国立病院機構北海道医療センター(臨床研究部), 独立行政法人国立病院機構北海道医療センター, 院長
Affiliation (based on the past Project Information) *help	2007: Hokkaido University, Grad. School of Med., Lecture 2006: Hokkaido University, Graduate School of Med., Assistant Professor, 大学院医学研究科, 助教授 2006: 北海道大学, 大学院医学研究科, 非常勤講師 2003 – 2004: 北海道大学, 大学院・医学研究科, 助教授 2003: 北海道大学, 医学研究科, 助教授 … More 2003: 北海道大学, 大学院・医学研究科, 教授 2002: Hokkaido University School of Medicine, Department of Neurology, Assistant Professor, 大学院・医学研究科, 講師 2001: 北海道大学, 医学部, 助手 1997 – 1999: 北海道大学, 医学部, 助手 Less
Review Section/Research Field	Principal Investigator Neurology / Neurology Except Principal Investigator Neurology / Cerebral neurosurgery / Psychiatric science / Biological Sciences
Keywords	Principal Investigator motor neuron / ALS / oxidative stress / glycation / susceptible genes / genes / multiple sclerosis / 疾患感受性 / 遺伝子 / 多発性硬化症 … More / Carboxymethyl lysine / Spinal motor neuron / Advanced glycation end product / Amyotrophic lateral sclerosis / 脊髄器官培養 / 分子生物学 / ユビキチン・プロテアソーム系 / 運動ニューロン / カルボキシメチルリジン / 脊髄運動ニューロン / 最終糖化産物 / 筋萎縮性側索硬化症 / advanced glycation end products (AGES) / AGE / advanced glycation end products(AGE) … More Except Principal Investigator Migration / Differentiation / Transplantation / Spinal cord injury / attack-related severity / human leukocyte antigen / 遺伝子 / Bone marrow stromal cells / Cerebral infarction / Neuroprotection / Biomaterial / Cerebral stroke / DNA microarray / Regererative medicine / Cognitive function / Diffuse brain injury / Bone carrow stromal cell / Regenerative medicine / Bone marrow stromal cell / susceptibility gene / prevalence / epidemiological research / multiple sclerosis / 脱髄 / 中枢神経 / 免疫 / MBP反応性T細胞 / サイトカイン / 髄液 / ケモカイン / osteopontin / 視神経脊髄型 / HLA / CTLA-4 / TRAIL / 遺伝子多型 / 多発生硬化症 / 疾患感受性遺伝子 / 有病率 / 疫学調査 / 多発性硬化症 / neurodegenerative diseases / Alzheimer's disease / Glycation / AGE-2 derived Aβ (1-40) / Aβ (1-40) / AGE-2 structure / Advanced glycation end-product / Advanced Glycation End-product / 神経変性疾患 / アルツハイマー病 / グリケーション / AGE-2化Aβ(1→40) / Aβ(1→40) / AGE-2構造体 / Advanced Glycation End-products / 終末糖化産物 / 発症機序 / 脊髄小脳変性症 / cDNA / 第17染色体 / 神経筋疾患 / ウイルスベクター / 遺伝子治療 / 遺伝子変異 / 筋萎縮性側索硬化症 / 神経筋症患 Less

Approach to find the susceptible genes for multiple sclerosisPrincipal Investigator
- Principal Investigator
  
  KIKUCHI Seiji
- Project Period (FY)
  2006 – 2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University
RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM FOCUSED ON AXON EXTENSION FROM THE HOST NEURONS
- Principal Investigator
  
  KOBAYASHI H., 七戸秀夫
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Cerebral neurosurgery
- Research Institution
  HOKKAIDO UNIVERSITY
皮質性小脳萎縮症の病因遺伝子および発症機序解明に関する研究
- Principal Investigator
  
  佐々木秀直
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
Investigation of clinical and immunological heterogeneity of multiple sclerosis, and its moleculogenetical background
- Principal Investigator
  
  TASHIRO Kunio
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Health Sciences University of Hokkaido
  Hokkaido University
The Association of AGEs (Advanced Glycation End product) and oxoaldehydes with spinal motor neuronal deathPrincipal Investigator
- Principal Investigator
  
  KIKUCHI Seiji
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
The study for neurotoxicity of advanced glycation end-products (the structural epitope AGE-2) in neurodegenerative processes
- Principal Investigator
  
  TAKEUCHI Masayoshi
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Psychiatric science
- Research Institution
  Hokuriku University
Glycation and AGEs in motor neurons - synergism with oxidative stress -Principal Investigator
- Principal Investigator
  
  KIKUCHI Seiji
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  HOKKAIDO UNIVERSITY
神経・筋症患の遺伝子治療に関する基礎的研究
- Principal Investigator
  
  MORIKAWA Fumio
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Hokkaido University

All 2005 2004 2003 2002 Other

All Journal Article Book

[Book] 酸化ストレスナビゲーター2005
- Author(s)
  菊地誠志
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] CSF pleocytosis and expansion of spinal lesions in Japanese MS : A special reference to the new diagnostic criteria2005
- Author(s)
  Fukazawa T, Kikuchi S, Tashiro K, et al.
- Journal Title
  
  Journal of Neurology 252(Published online March 6,1-)
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Possible participation of advanced glycation end products (AGEs) in the pathogenesis of colorectal cancer in diabetic patients.2005
- Author(s)
  Yamagishi S, Nakamura K, Inoue H, Kikuchi S, Takeuchi M
- Journal Title
  
  Medical Hypotheses 64
  
  Pages: 1208-1210
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Attack-related severity : Akey factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders2004
- Author(s)
  Fukazawa T, Kikuchi S, Niino M, Tashiro K., et al.
- Journal Title
  
  Journal of the Neurological Sciences 225
  
  Pages: 71-78
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Oxidative stress and neurodegenerative diseases2004
- Author(s)
  Tsuji S, Kikuchi S
- Journal Title
  
  Rinshokensa 49
  
  Pages: 183-187
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Ibudilast, a non-selective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in MS2004
- Author(s)
  Feng J, Fukaura H, Kikuchi S, Tashiro k, et al.
- Journal Title
  
  Multiple Sclerosis 10
  
  Pages: 494-498
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Platelet-activating factor acethylhydrolase gene polymorphism and its activity in Japanese patients with multiple sclerosis2004
- Author(s)
  Osoegawa M, Niino M, Kikuchi S, Tashiro K, et al.
- Journal Title
  
  Journal of Neuroimmunology 150
  
  Pages: 150-156
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Glyceraldehyde-derived advanced glycation end products in Alzheimer's disease2004
- Author(s)
  Choei H, Sasaki N, Takeuchi M, Yoshida T, Ukai W, Yamagishi S, Kikuchi S, Saito T
- Journal Title
  
  Acta Neuropathol (Berl) 108
  
  Pages: 189-193
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] HLA-related subpopulations of MS in Japanese with and without oligoclonal IgG bands.2003
- Author(s)
  Kikuchi S
- Journal Title
  
  Neurology 60
  
  Pages: 647-651
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Brefeldin A-induced neurotoxicity in cultured.spinal cord neurons.2003
- Author(s)
  Kikuchi S, Shinpo K, Tsuji S, Yabe I, Niino M, Tashiro K
- Journal Title
  
  J Neurosci Res 71
  
  Pages: 591-599
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Glycation -a sweet tempter for neuronal death2003
- Author(s)
  Kikuchi S, Shinpo K, Takeuchi M, Yamagishi S, Makita Z, Sasaki N, Tashiro K
- Journal Title
  
  Brain Research Reviews 41
  
  Pages: 306-323
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Neurotoxicity of acetaldehyde-derived advanced glycation end products for cultured cortical neurons2003
- Author(s)
  Takeuchi M, Watai T, Sasaki N, Choei H, Iwaki M, Ashizawa T, Inagaki Y, Yamagishi S, Kikuchi S, Peter Riederer, Saito T, Richard Bucara, Kameda Y
- Journal Title
  
  J Neuropathol Exp Neurol 62
  
  Pages: 486-496
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Brefeldin A-induced neurotoxicity in cultured spinal cord neurons2003
- Author(s)
  KIKUCHI S
- Journal Title
  
  Journal of neuroscience Research 71
  
  Pages: 591-599
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Effect of proteasome inhibitor on cultured mesencephalic dopaminergic neurons2003
- Author(s)
  KIKUCHI S
- Journal Title
  
  Brain Research 964
  
  Pages: 228-236
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Glycation - a sweet tempter for neuronal death2003
- Author(s)
  KIKUCHI S
- Journal Title
  
  Brain Research Reviews 41
  
  Pages: 306-323
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients: interaction with HLA-DRB1*1501 and disease modulation.2002
- Author(s)
  Kikuchi S
- Journal Title
  
  J Neuroimmunol 128
  
  Pages: 77-81
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] An assessment of the association between IL-2 gene polymorphism and Japanese patients with multiple sclerosis.2002
- Author(s)
  Kikuchi S
- Journal Title
  
  J Neurol Sci 205
  
  Pages: 47-50
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] 疫学および免疫学的側面から見た多発性硬化症関連候補遺伝子の検討2002
- Author(s)
  菊地誠志
- Journal Title
  
  神経免疫学 10
  
  Pages: 185-190
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Incadronate disodium inhibits advanced glycation end products-induced angiogenesis in vitro2002
- Author(s)
  Okamoto T, Yamagishi S, Inagaki Y, Amano S, Takeuchi M, Kikuchi S, Ohno S, Yoshimura A
- Journal Title
  
  Biochem Bioph Res Co 297
  
  Pages: 419-424
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Effect of Geranylgeranylaceton on Cellular Damage Induced by Proteasome Inhibition in Culutured Spinal Neurons2002
- Author(s)
  Kikuchi S, Shinpo K, Takeuchi M, Tsuji S, Yabe I, Niino M, Tashiro K
- Journal Title
  
  Journal of Neuroscience Research 69
  
  Pages: 373-381
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Prostaglandin E1 protects cultured spinal neurons against the effects of nitiric oxide toxicity2002
- Author(s)
  Kikuchi S, Shinpo K, Niino M, Tsuji S, Iwabuchi K, Onoe K, Tashiro K
- Journal Title
  
  Neuropharmachology 42
  
  Pages: 714-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Prostaglandin E1 protects cultured spinal neurons against the effects of nitiric oxide toxicity2002
- Author(s)
  KIKUCHI S
- Journal Title
  
  Neuropharmachology 42
  
  Pages: 714-723
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Detection of N^E-(carboxymethyl) lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord2002
- Author(s)
  Kikuchi S, Shinpo K, Ogata A, Tsuji S, Takeuchi M, Makita Z, Tashiro K
- Journal Title
  
  ALS and other motor neuron disorders 3
  
  Pages: 63-66
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Detection of N^E-(carboxymethyl) lysine (CML) and non-CML advanced glycation end-products in the anterior horn of amyotrophic lateral sclerosis spinal cord2002
- Author(s)
  KIKUCHI S
- Journal Title
  
  ALS and other motor neuron disorders 3
  
  Pages: 63-66
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Effect of Geranylgeranylaceton on Cellular Damage Induced by Proteasome Inhibition in Culutured Spinal Neurons2002
- Author(s)
  KIKUCHI S
- Journal Title
  
  Journal of Neuroscience Research 69
  
  Pages: 373-381
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Estrogen receptor gene polymorphism and multiple sclerosis in Japanese patients interaction with HLA.DRB1^*1501 and disease modulation.2002
- Author(s)
  Kikuchi S
- Journal Title
  
  J Neuroimmunol 128
  
  Pages: 77-81
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370201
[Journal Article] Advanced glycation end products (AGE) and their receptor (RAGE) in the brain of patients with Creutzfeldt-Jakob disease with prion plaques2002
- Author(s)
  Sasaki N, Takeuchi M, Chowei H, Kikuchi S, Hayashi Y, Nakano N, Ikeda H, Yamagishi S, Kitamoto T, Saito T, Makita Z
- Journal Title
  
  Neurosci Lett 326
  
  Pages: 117-120
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Serum or cerebrospinal fluid levels of glyceraldehydes-derived advanced glycation end products (AGEs) may be a promising biomarker for early detection of Alzheimer's disease.
- Author(s)
  Yamagishi S, Nakamura K, Inoue H, Kikuchi S, Takeuchi M
- Journal Title
  
  Medical Hypotheses (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574
[Journal Article] Blockade by nifedipine of advanced glycation end product-induced CD40-CD40 ligand interaction in endothelial cells
- Author(s)
  Yamagishi S, Kikuchi S, Takenaka K, Takeuchi M
- Journal Title
  
  Drugs Exp Clin Res
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570574

1. MORIKAWA Fumio (30142722)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
2. TASHIRO Kunio (90002154)

# of Collaborated Projects: 4 results

# of Collaborated Products: 9 results
3. KOBAYASHI H. (70374478)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. YABE Ichiro (60372273)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. TAKEUCHI Masayoshi (20154982)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
6. SASAKI Nobuyuki (60315497)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. KURODA S. (10301904)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. IWASAKI Y. (00113522)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. YANO S. (20374481)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. HIDA K. (10238305)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. INOKO Hidetoshi (10101932)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
12. 佐々木秀直 (80281806)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
13. 七戸秀夫 (80374479)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

kikuti seiji 菊地 誠志

KIKUCHI S. 菊地 誠志

KIKUCHI Seiji 菊地 誠志

Research Projects

Research Products

Co-Researchers

Approach to find the susceptible genes for multiple sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

RESEARCH FOR BONE MARROW STROMAL CELLS (BMSC) TRANSPLANTATION THERAPY FOR INJURED CENTRAL NERVOUS SYSTEM FOCUSED ON AXON EXTENSION FROM THE HOST NEURONS

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

皮質性小脳萎縮症の病因遺伝子および発症機序解明に関する研究

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Investigation of clinical and immunological heterogeneity of multiple sclerosis, and its moleculogenetical background

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The Association of AGEs (Advanced Glycation End product) and oxoaldehydes with spinal motor neuronal deathPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

The study for neurotoxicity of advanced glycation end-products (the structural epitope AGE-2) in neurodegenerative processes

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Glycation and AGEs in motor neurons - synergism with oxidative stress -Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

神経・筋症患の遺伝子治療に関する基礎的研究

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Book] 酸化ストレスナビゲーター2005

Author(s)

Description

Data Source

[Journal Article] CSF pleocytosis and expansion of spinal lesions in Japanese MS : A special reference to the new diagnostic criteria2005

Author(s)

Journal Title

Data Source

[Journal Article] Possible participation of advanced glycation end products (AGEs) in the pathogenesis of colorectal cancer in diabetic patients.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Attack-related severity : Akey factor in understanding the spectrum of idiopathic inflammatory demyelinating disorders2004

Author(s)

Journal Title

Data Source

[Journal Article] Oxidative stress and neurodegenerative diseases2004

Author(s)

Journal Title

Description

Data Source

[Journal Article] Ibudilast, a non-selective phosphodiesterase inhibitor, regulates Th1/Th2 balance and NKT cell subset in MS2004

Author(s)

Journal Title

Data Source

kikuti seiji 菊地誠志

KIKUCHI S. 菊地誠志

KIKUCHI Seiji 菊地誠志