OHASHI Takashi 大橋貴

Researcher Number	10282774
Other IDs
External Links
Affiliation (based on the past Project Information) *help	2007 – 2016: Hokkaido University, 遺伝子病制御研究所, 准教授 2004 – 2006: Hokkaido Univ., Institute for Genetic Medicine, Associate Professor, 遺伝子病制御研究所, 助教授 2000 – 2003: 東京医科歯科大学, 大学院・医歯学総合研究科, 助手 1997 – 1999: 東京医科歯科大学, 医学系研究科, 助手
Review Section/Research Field	Principal Investigator Virology / Biological Sciences / Virology Except Principal Investigator Virology / Biological Sciences
Keywords	Principal Investigator ATL / HTLV-I / CTL / Tax / animal model / MHC-I / Single chain trimer / 動物モデル / 成人T細胞白血病 / siRNA … More / CRM1 / HTLV-1 / ウイルス療法 / 免疫治療 / Epitope / Animal model / vaccine / suppression / AIDS / T cell / CD8 / HIV / エピトープ / ワクシニアウイルス / transgenic rat / Transgenic rat / single chain trimer / T細胞受容体 / Vaccinia / rat / Enitope / 細胞傷害性T細胞 / レトロウイルス / MHC-I単鎖三量体 / DNA vaccine / HTLY-I / peptide / epitope / HYLV-I / Tcell / SDF-1 / Suppression … More Except Principal Investigator HIV / HTLV-1 / 感染モデル / HIV-1 / ラット / rat model / ラットモデル / 治療法 / エイズワクチン / トランスジェニックラット Less

ＨＴＬＶ－Ｉ関連疾患モデルラットに対する腫瘍溶解性ワクシニアウイルスの治療応用Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2015 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
Development of HTLV-I-specific anti-cancer therapy by using single chain T cell receptors and single chain trimers of MHC-I.Principal Investigator
- Principal Investigator
  
  OHASHI Takashi
- Project Period (FY)
  2012 – 2014
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
Development of immunotherapy and virotherapy against ATLPrincipal Investigator
- Principal Investigator
  
  OHASHI Takashi
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
Analysis of anti-HTLV-I immune response and development of immunotherapy by using single-chain trimers of MHC-IPrincipal Investigator
- Principal Investigator
  
  OHASHI Takashi
- Project Period (FY)
  2007 – 2008
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  Hokkaido University
Human CRM1 expressing small animal model for HIV-1/HTLV-1 infections
- Principal Investigator
  
  SHIDA Hisatoshi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Virology
- Research Institution
  HOKKAIDO UNIVERSITY
Establishment of an HTLV-I infection model by using human CRM1-transgenic ratsPrincipal Investigator
- Principal Investigator
  
  OHASHI Takashi
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  HOKKAIDO UNIVERSITY
トランスジェニックラット感染モデルを用いたエイズワクチン・治療法開発
- Principal Investigator
  
  SHIDA Hisatoshi
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Hokkaido University
ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2003
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
Functional analysis of HTLV-I Tax in vivo using a rat model systemPrincipal Investigator
- Principal Investigator
  
  OHASHI Takashi
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Virology
- Research Institution
  HOKKAIDO UNIVERSITY
  Tokyo Medical and Dental University
ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
ラットモデルを用いたヒト成人T細胞白血病に対するDNAワクチンの開発Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
ラットモデルを用いたヒト成人T細胞白血病の発症機序の解析Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Virology
- Research Institution
  Tokyo Medical and Dental University
ラットモデルを用いたヒト成人T細胞白血病の発症に関わる因子についての研究Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  2000
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  Tokyo Medical and Dental University
エイズウイルスの増殖抑制に関与するCD8陽性T細胞由来因子の研究Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Tokyo Medical and Dental University
CD8陽性T細胞によるエイズウイルス産生抑制機構Principal Investigator
- Principal Investigator
  
  大橋貴
- Project Period (FY)
  1997 – 1998
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Virology
- Research Institution
  Tokyo Medical and Dental University

All 2015 2014 2012 2011 2010 2009 2008 2007

All Journal Article Presentation

[Journal Article] Osteopontin-integrin interaction as a novel molecular target for antibody-mediated immunotherapy in adult T-cell leukemia.2015
- Author(s)
  1.Maeda N, Ohashi T, Chagan-Yasutan, H, Hattori T, Takahashi Y, Harigae, H, Hasegawa H, Yamada Y, Fujii M, Maenaka K, and Uede T.
- Journal Title
  
  Retrovirology
  
  Volume: 12 Issue: 1 Pages: 99-99
- DOI
  10.1186/s12977-015-0225-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15K08490, KAKENHI-PROJECT-15H02384, KAKENHI-PROJECT-15H04704
[Journal Article] Combined Cytolytic Effects of a Vaccinia Virus Encoding a Single Chain Trimer of MHC-I with a Tax-Epitope and Tax-Specific CTLs on HTLV-I-Infected Cells in a Rat Model2014
- Author(s)
  Ohashi T, Nakamura T, Kidokoro M, Zhang X, Shida H
- Journal Title
  
  BioMed Research International.
  
  Volume: 2014 Pages: 902478-902478
- DOI
  10.1155/2014/902478
- NAID
  120005434503
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24300340, KAKENHI-PROJECT-24590547, KAKENHI-PROJECT-24650629, KAKENHI-PROJECT-26640103
[Journal Article] Effects of different promoters on the virulence and immunogenicity of a HIV-1 Env-expressing recombinant vaccinia vaccine.2014
- Author(s)
  Isshiki M, Zhang X, Sato H, Ohashi T, Inoue M, and Shida H.
- Journal Title
  
  Vaccine
  
  Volume: ３２ Issue: 7 Pages: 839-845
- DOI
  10.1016/j.vaccine.2013.12.022
- Peer Reviewed / Acknowledgement Compliant / Open Access
- Data Source
  KAKENHI-PROJECT-24590547
[Journal Article] Elicitation of both anti HIV-1 env humoral and cellular immunities by replication vaccinia prime sendai virus boost regimen and boosting by CD40Lm2012
- Author(s)
  Zhang X
- Journal Title
  
  PLoS ONE
  
  Volume: 7 Issue: 12 Pages: 1-11
- DOI
  10.1371/journal.pone.0051633
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22390118, KAKENHI-PROJECT-24310146, KAKENHI-PROJECT-24590547
[Journal Article] Nuclear and cytoplasmic effects of human CRM1 on HIV-1 production in rat cells2011
- Author(s)
  Nagai-Fukataki M, Ohashi T, Hashimoto I, Kimura T, Hakata Y, Shida H
- Journal Title
  
  Genes Cells
  
  Volume: 16 Pages: 203-216
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Inhibitory effect of human TRIM5alpha on HIV-1 production2010
- Author(s)
  Zhang X., Kondo M., Chen J., Miyoshi H., Suzuki H., Ohashi T., and Shida H
- Journal Title
  
  Microbes Infect
  
  Volume: 12 Pages: 768-777
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages2009
- Author(s)
  Okada H., Zhang X., Fofana IB., Nagai M., Suzuki H., Ohashi T., and Shida H
- Journal Title
  
  Retrovirology
  
  Volume: 6 Issue: 12 Pages: 43-43
- DOI
  10.1016/j.micinf.2009.06.007
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Induction of IL-10-and IFN-g-producing T-cell responses by autoreactive T-cells expressing human T-cell leukemia virus type I Tax2009
- Author(s)
  Takatsuka N., Hasegawa A., Takamori A., Shimizu Y., Kato H., Ohashi T., Amagasa T., Masuda T., Kannagi M
- Journal Title
  
  Int. Immunol
  
  Volume: 21 Issue: 10 Pages: 1089-1100
- DOI
  10.1016/j.micinf.2010.05.004
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Functional analysis of Foxp3 and CTLA-4 expressing HTLV-1-infected cells in a rat model2009
- Author(s)
  Takayanagi R., Ohashi T., and Shida H
- Journal Title
  
  Microbes Infect
  
  Volume: 11 Issue: 9 Pages: 964-972
- DOI
  10.1093/intimm/dxp089
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Immunogenicity of newly constructed attenuated vaccinia strain LC16m8△ that expresses SIV Gag protein2009
- Author(s)
  Suzuki H., Kidokoro M., Fofana IB., Ohashi T., Okamura T., Honda M., Yamamoto N., and Shida H
- Journal Title
  
  Vaccine
  
  Volume: 27 Issue: 1 Pages: 966-971
- DOI
  10.1186/1742-4690-6-43
- Data Source
  KAKENHI-PROJECT-21590504
[Journal Article] Activation and Detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model2008
- Author(s)
  Ohashi T., Nagai M., Okada H., Takayanagi R. and Shida H.
- Journal Title
  
  Retrovirology 5
  
  Pages: 90-90
- Data Source
  KAKENHI-PROJECT-19590466
[Journal Article] Activation and Detection of HTLV-I Tax-specific CTLs by Epitope expressing Single-Chain Trimers of MHC Class I in a rat model2008
- Author(s)
  Ohashi T., et.al.
- Journal Title
  
  Retrovirology 5
  
  Pages: 90-90
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-19590466
[Journal Article] Enhanced Replication of Human T-cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner.2007
- Author(s)
  Ryo Takayanagi, Takashi Ohashi, et al.
- Journal Title
  
  J. Virol. 81 (in press)
- Data Source
  KAKENHI-PROJECT-17390131
[Journal Article] Hisatoshi Shida Enhanced Replication of Human T-cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner.2007
- Author(s)
  Ryo Takayanagi, Takashi Ohashi, Eizaburo Yamashita, Yohei Kurosaki, Kumiko Tanaka, Yoshiyuki Hakata, Yasumasa Komoda, Satoru Ikeda, Yasuko Tsunetsugu-Yokota, Yuetsu Tanaka
- Journal Title
  
  J. Virol. (In press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17390131
[Journal Article] Enhanced Replication of Human T-cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner2007
- Author(s)
  Takayanagi R., Ohashi T., Yamashita E., Kurosaki Y., Tanaka K., Hakata Y., Komoda Y., Ikeda S., Tsunetsugu-Yokota Y., Tanaka Y., and Shida H.
- Journal Title
  
  J Virol. 81
  
  Pages: 5908-5918
- Data Source
  KAKENHI-PROJECT-19590466
[Journal Article] Enhanced Replication of Human T-cell Leukemia Virus Type 1 in T Cells from Transgenic Rats Expressing Human CRM1 That Is Regulated in a Natural Manner.2007
- Author(s)
  Ryo Takayanagi, Takashi Ohashi et al.
- Journal Title
  
  J. Virol. 81(In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17390131
[Presentation] HTLV-Iに感染したTax特異的CTL細胞株の性状解析2012
- Author(s)
  大橋　貴、田中勇悦、志田壽利
- Organizer
  第６０回日本ウイルス学会学術集会
- Place of Presentation
  大阪国際会議場 ( 大阪府 )
- Data Source
  KAKENHI-PROJECT-24590547
[Presentation] ラットモデルを用いた低病原性ワクシニアウイルスの抗HTLV-I腫瘍効果の解析2011
- Author(s)
  大橋貴
- Organizer
  第4回HTLV-I研究会
- Place of Presentation
  東京大学弥生講堂(東京)
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-21590504
[Presentation] ラットモデルを用いた低病原性ワクシニアウイルスの抗HTLV-I腫瘍効果の解析2011
- Author(s)
  大橋貴、中村貴史、木所稔、志田壽利
- Organizer
  第4回HTLV-I研究会
- Place of Presentation
  東京大学弥生講堂
- Year and Date
  2011-09-19
- Data Source
  KAKENHI-PROJECT-21590504
[Presentation] ラットモデルにおけるMHC-I単鎖三量体を用いたHTLV-ITax特異的CTLの活性化と検出2008
- Author(s)
  大橋貴、志田壽利
- Organizer
  第42回日本ウイルス学会北海道支部会夏季シンポジウム
- Place of Presentation
  ニセコ
- Year and Date
  2008-07-26
- Data Source
  KAKENHI-PROJECT-19590466

1. SHIDA Hisatoshi (00144395)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. KIDOKORO Minoru (00370958)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
3. 原嶋奈々江 (60345311)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
4. 博多義之 (30344500)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
5. 中村貴史

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

OHASHI Takashi 大橋 貴

Research Projects

Research Products

Co-Researchers

ＨＴＬＶ－Ｉ関連疾患モデルラットに対する腫瘍溶解性ワクシニアウイルスの治療応用Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of HTLV-I-specific anti-cancer therapy by using single chain T cell receptors and single chain trimers of MHC-I.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Development of immunotherapy and virotherapy against ATLPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Analysis of anti-HTLV-I immune response and development of immunotherapy by using single-chain trimers of MHC-IPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Human CRM1 expressing small animal model for HIV-1/HTLV-1 infections

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Establishment of an HTLV-I infection model by using human CRM1-transgenic ratsPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

トランスジェニックラット感染モデルを用いたエイズワクチン・治療法開発

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Functional analysis of HTLV-I Tax in vivo using a rat model systemPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラットモデルを用いたヒト成人T細胞白血病に対する免疫療法の開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ラットモデルを用いたヒト成人T細胞白血病に対するDNAワクチンの開発Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

ラットモデルを用いたヒト成人T細胞白血病の発症機序の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ラットモデルを用いたヒト成人T細胞白血病の発症に関わる因子についての研究Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

OHASHI Takashi 大橋貴