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SAKUMA YASUNARU  佐久間 康成

Researcher Number 10296105
Other IDs
  • ORCIDhttps://orcid.org/0000-0003-3633-3221
Affiliation (Current) 2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help 2019 – 2024: 自治医科大学, 医学部, 教授
2014 – 2018: 自治医科大学, 医学部, 准教授
Review Section/Research Field
Principal Investigator
Basic Section 55010:General surgery and pediatric surgery-related / General surgery
Except Principal Investigator
Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55010:General surgery and pediatric surgery-related / General surgery / Basic Section 55020:Digestive surgery-related / Basic Section 55050:Anesthesiology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56030:Urology-related / Digestive surgery
Keywords
Principal Investigator
病態解明 / 早期診断 / 小児肝疾患 / 質量分析イメージング法 / 質量分析イメージング / 網羅歴メタボローム解析 / 胆汁酸分析 / NASH / 肥満 / 脂肪肝 … More / 褐色脂肪 / 非アルコール性脂肪肝炎 / 肥満治療 / 脂肪幹細胞 / 褐色細胞腫 / 細胞移植 / 表面マーカー / 褐色脂肪細胞 … More
Except Principal Investigator
メタボローム解析 / 腸管不全関連肝障害 / ポリアミン / 短腸症 / 悪液質 / オステオペニア / 骨密度 / 体組成変化 / 癌患者 / 悪性度 / 質量分析 / 体液 / がん診断 / 薬物血中濃度 / 網羅的メタボローム解析 / 術後悪心嘔吐 / 組織Q-FISH法 / 線維化マーカー / 細胞老化関連マーカー / 小児肝移植 / テロメア / フェロトーシス / 化学放射線療法耐性 / 直腸癌 / 物質分析イメージング法 / 肝移植後拒絶反応 / 胆汁 / 拒絶反応 / 直接イオン化法 / 骨髄前駆細胞 / 前転移ニッチ / 癌転移 / 好中球 / 腹膜播種 / 肺転移 / エクソソーム / 好中球細胞外トラップ / 薬物動態 / タクロリムス腎症 / メタボローム / 臓器移植 / 腎移植 / 腎症 / タクロリムス / 術後補助療法 / 個別化治療 / 副作用発現因子 / 効果予測因子 / 予後因子 / マイクロRNA / 化学療法 / 膵癌 / マイクロRNA / IgA / 腸管不全合併肝障害 / 腸内細菌 / タイトジャンクション / IgA / 脂肪肝 / 小腸不全関連肝障害 / 腸管免疫 Less
  • Research Projects

    (13 results)
  • Research Products

    (30 results)
  • Co-Researchers

    (44 People)
  •  Prognostic biomarkers of allograft in pediatric liver transplantation

    • Principal Investigator
      眞田 幸弘
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Jichi Medical University
  •  Posthepatectomy Fentanyl Blood Levels and Comprehensive Metabolome Analysis of PONV Risk Factors

    • Principal Investigator
      竹内 護
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55050:Anesthesiology-related
    • Research Institution
      Jichi Medical University
  •  Development of novel cancer diagnosis system using innovative ionization mass spectrometry using body fluid samples

    • Principal Investigator
      佐田 尚宏
    • Project Period (FY)
      2023 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Jichi Medical University
  •  体組成変化と大腸癌肝転移の転移機構の解明と新規治療戦略の開発

    • Principal Investigator
      三木 厚
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55020:Digestive surgery-related
    • Research Institution
      Jichi Medical University
  •  化学放射線療法耐性直腸癌に対するフェロトーシス誘導療法の開発

    • Principal Investigator
      井上 賢之
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 50020:Tumor diagnostics and therapeutics-related
    • Research Institution
      Jichi Medical University
  •  Early Diagnosis and Pathophysiology of Pediatric Liver Disease by Bile Acid Analysis and Mass Spectrometry ImagingPrincipal Investigator

    • Principal Investigator
      佐久間 康成
    • Project Period (FY)
      2022 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Jichi Medical University
  •  Analysis of the pathogenesis of tacrolimus nephropathy by integrating drug distribution kinetics in renal tissue and metabolomic analysis

    • Principal Investigator
      Iwami Daiki
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (B)
    • Review Section
      Basic Section 56030:Urology-related
    • Research Institution
      Jichi Medical University
  •  Significance of neutrophil extracellular traps in the formation of pre-metastatic niches by exosomes

    • Principal Investigator
      Onishi Yasuharu
    • Project Period (FY)
      2021 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 55010:General surgery and pediatric surgery-related
    • Research Institution
      Jichi Medical University
  •  肝移植後拒絶反応の病態解明と直接イオン化法による革新的迅速診断法の開発

    • Principal Investigator
      平田 雄大
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Challenging Research (Exploratory)
    • Review Section
      Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
    • Research Institution
      Jichi Medical University
  •  Dietary spermidine and spermine intake strengthen intestine barrier and prevent hepatocyte lipid droplet deposition in rodent short bowel syndrome model

    • Principal Investigator
      Kasahara Naoya
    • Project Period (FY)
      2017 – 2020
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Jichi Medical University
  •  Study for therapeutic strategy of pancreatic cancer using microRNA expresssion profiles

    • Principal Investigator
      Sata Naohiro
    • Project Period (FY)
      2017 – 2019
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Digestive surgery
    • Research Institution
      Jichi Medical University
  •  Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissuePrincipal Investigator

    • Principal Investigator
      SAKUMA YASUNARU
    • Project Period (FY)
      2014 – 2017
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Jichi Medical University
  •  Oral administration of polyamines promote adaptation in rodent model of short bowel syndrome

    • Principal Investigator
      Kasahara Naoya
    • Project Period (FY)
      2014 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      General surgery
    • Research Institution
      Jichi Medical University

All 2023 2022 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

  • [Journal Article] Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma.2023

    • Author(s)
      Miki A, Sakuma Y, Watanabe J, Endo K, Sasanuma H, Teratani T, Lefor AK, Kitayama J, Sata N.
    • Journal Title

      Current Oncology

      Volume: 30(2) Issue: 2 Pages: 1860-1868

    • DOI

      10.3390/curroncol30020144

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08139, KAKENHI-PROJECT-23K24411
  • [Journal Article] Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy2023

    • Author(s)
      Miki A, Sakuma Y, Watanabe J, Endo K, Sasanuma H, Teratani T, Lefor AK, Shimizu A, Kitayama J, Yasuda Y, Sata N.
    • Journal Title

      Scientific Reports

      Volume: 13(1) Issue: 1 Pages: 15637-15637

    • DOI

      10.1038/s41598-023-42929-x

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-23K08139
  • [Journal Article] COMPLEMENTARY INDICATORS FOR DIAGNOSIS OF HEPATIC VEIN STENOSIS AFTER PEDIATRIC LIVING DONOR LIVER TRANSPLANTATION2016

    • Author(s)
      Kawano Youichi
    • Journal Title

      Transplantation Proceedings

      Volume: S0041 Issue: 4 Pages: 234-237

    • DOI

      10.1016/j.transproceed.2015.12.114

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-24592013, KAKENHI-PROJECT-26461925
  • [Journal Article] Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation.2016

    • Author(s)
      Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, Sakuma Y, Yagisawa T
    • Journal Title

      Transpl Infect Dis

      Volume: 18 Issue: 2 Pages: 234-239

    • DOI

      10.1111/tid.12519

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461925
  • [Journal Article] The outcomes of pediatric living donor liver transplantation using small-for-size grafts: experience of a single institute.2016

    • Author(s)
      Yamada N, Sanada Y, Hirata Y, Okada N, Ihara Y, Sasanuma H, Urahashi T, Sakuma Y, Yasuda Y, Mizuta K
    • Journal Title

      Pediatr Surg Int.

      Volume: 19 Issue: 4 Pages: 363-368

    • DOI

      10.1007/s00383-016-3859-4

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461925
  • [Journal Article] Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report.2016

    • Author(s)
      Yamada N, Sanada Y, Katano T, Tashiro M, Hirata Y, Okada N, Ihara Y, Miki A, Sasanuma H, Urahashi T, Sakuma Y, Mizuta K.
    • Journal Title

      World J Gastroenterol

      Volume: 22 Pages: 9865-9870

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461925
  • [Journal Article] Immunohistochemical evaluation for outflow reconstruction using opened round ligament in living donor right posterior sector graft liver transplantation: A case report.2016

    • Author(s)
      Sanada Y
    • Journal Title

      World J Gastroenterol

      Volume: 22(34) Issue: 34 Pages: 7851-6

    • DOI

      10.3748/wjg.v22.i34.7851

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
  • [Journal Article] Living-Donor Liver Transplantation Using Segment 2 Monosegment Graft: A Single-Center Experience.2016

    • Author(s)
      Sakuma Y
    • Journal Title

      Transplant Proc

      Volume: 48(4) Issue: 4 Pages: 1110-4

    • DOI

      10.1016/j.transproceed.2015.12.119

    • Peer Reviewed / Open Access / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
  • [Journal Article] Selection of living donor liver grafts for patients weighing 6kg or less2015

    • Author(s)
      Naoya Yamada
    • Journal Title

      Liver Transplantation

      Volume: 21(2) Issue: 2 Pages: 233-238

    • DOI

      10.1002/lt.24048

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
  • [Journal Article] The impact of rituximab in ABOincompatible pediatric living donor liver transplantation: The experience of a single center2015

    • Author(s)
      Noriki Okada, Yukihiro Sanada, Yuta Hirata, Naoya Yamada, Taiichi Wakiya, Yoshiyuki Ihara, Taizen Urahashi, Atsushi Miki, Yuji Kaneda, Hideki Sasanuma, Takehito Fujiwara, Yasunaru Sakuma, Atsushi Shimizu, Masanobu Hyodo, Yoshikazu Yasuda, Koichi Mizuta
    • Journal Title

      Pediatric Transplantation

      Volume: 19 Issue: 3 Pages: 279-286

    • DOI

      10.1111/petr.12445

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461925
  • [Journal Article] Improved human islet preparations using glucocorticoid and exendin-42014

    • Author(s)
      Atsushi Miki
    • Journal Title

      Pancreas

      Volume: 43(8) Issue: 8 Pages: 1317-1322

    • DOI

      10.1097/mpa.0000000000000184

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
  • [Journal Article] Risk Factors of Cytomegalovirus Infection After Pediatric Liver Transplantation2014

    • Author(s)
      Y. Kawano, K. Mizuta, Y. Sanada, T. Urahashi, Y. Ihara, N. Okada, N. Yamada, H. Sasanuma, Y. Sakuma, N. Taniai, H. Yoshida, H. Kawarasaki, Y. Yasuda, and E. Uchida
    • Journal Title

      Transplantation Proceedings

      Volume: 46 Issue: 10 Pages: 3543-3547

    • DOI

      10.1016/j.transproceed.2014.09.150

    • Peer Reviewed / Open Access
    • Data Source
      KAKENHI-PROJECT-26461925
  • [Presentation] 【肝胆膵】消化器移植医療の現状と今後の展望 チーム医療による肝移植の現状と今後の展望2022

    • Author(s)
      大西 康晴, 佐久間 康成, 眞田 幸弘, 岡田 憲樹, 平田 雄大, 堀内 俊男, 大豆生田 尚彦, 水田 耕一, 佐田 尚宏.
    • Organizer
      第77回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-21K08602
  • [Presentation] 切除不能膵頭部腫瘍による総胆管閉塞に対し、胃空腸バイパス術と胆道ステント留置を併施した一例2019

    • Author(s)
      窪木 大悟, 笹沼 英紀, 橋本 雄介, 三木 厚, 吉田 淳, 森嶋 計, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏
    • Organizer
      第55回日本胆道学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] Telomere長解析によるIPMN多段階発癌解析と悪性度診断2019

    • Author(s)
      三木 厚, 相田 順子, 森嶋 計, 遠藤 和洋, 吉田 淳, 笹沼 英紀, 佐久間 康成, 山口博紀, 田久保 海誉, 堀江 久永, 味村 俊樹, 細谷 好則, 福島 敬宜, 北山 丈二, 佐田 尚宏
    • Organizer
      第24回日本外科病理学会学術集会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 12年の長期経過観察中に悪性化したと考えられる膵粘液嚢胞性腫瘍の一例2019

    • Author(s)
      高橋 礼, 笹沼 英紀, 三木 厚, 森嶋 計, 吉田 淳, 遠藤 和洋, 佐久間 康成, 堀江 久永, 細谷 好則, 北山 丈二, 佐田 尚宏, 池田 恵理子, 福島 敬宜
    • Organizer
      第354回日本消化器病学会関東支部例会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 腹腔鏡下膵体尾部切除(Lap-DP)における定型化膵離断 膵臓の厚みとカートリッジに関する検討2018

    • Author(s)
      笹沼英紀, 佐久間康成, 木村有希, 青木裕一, 田口昌延, 森嶋計, 遠藤和洋, 吉田淳, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第31回日本内視鏡外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 膵体尾部切除術における膵断端処理と術後膵液瘻の検討2018

    • Author(s)
      木村有希, 小泉大, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第73回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 慢性膵炎急性増悪を契機に脾膿瘍を合併した1例2018

    • Author(s)
      寺田 茉位子, 吉田淳, 佐久間康成, 木村有希, 青木裕一, 森嶋計, 遠藤和洋, 笹沼英紀, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第80回日本臨床外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 膵頭部癌に対して膵頭十二指腸切除術を施行し膵尾側断端閉鎖を行った一例2018

    • Author(s)
      倉田佳彦, 木村有希, 青木裕一, 森嶋計, 遠藤和洋, 笹沼英紀, 吉田淳, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第80回日本臨床外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 膵頭十二指腸切除術を施行した十二指腸乳頭部癌の長期成績2018

    • Author(s)
      小泉大, 齋藤晶, 横田真一郎, 兼田裕司, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第118回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 膵頭部残膵再発に対して、初回左胃動脈温存が有用であった膵内分泌癌の再手術例2018

    • Author(s)
      泉遼, 遠藤和洋, 齋藤晶, 田口昌延, 三木厚, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
    • Organizer
      第49回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 切除可能膵癌に対する術前化学放射線治療の有用性.2017

    • Author(s)
      三木 厚,佐久間康成,笠原尚哉,遠藤和洋,小泉 大,笹沼英紀,堀江久永,細谷好則,北山丈二,佐田尚宏
    • Organizer
      第72回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 十二指腸腫瘍性病変に対する膵温存十二指腸切除術の治療成績.2017

    • Author(s)
      齋藤 晶,小泉 大,三木 厚,遠藤和洋,笹沼英紀,佐久間康成,堀江久永,細谷好則,北山丈二,佐田尚宏
    • Organizer
      第72回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 当科における膵IPMNの手術術式の検討.2017

    • Author(s)
      齋藤 匠,三木 厚,笠原尚哉,遠藤和洋,小泉 大,笹沼英紀,佐久間康成,堀江久永,細谷好則,北山丈二,佐田尚宏
    • Organizer
      第48回日本膵臓学会大会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 当科における膵IPMNの縮小手術の検討.2017

    • Author(s)
      齋藤 匠,三木 厚,遠藤和洋,小泉 大,笹沼英紀,佐久間康成,堀江久永,細谷好則,北山丈二,佐田尚宏
    • Organizer
      第72回日本消化器外科学会総会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] IPMN国際診療ガイドラインからみた当院でのIPMN手術例の検討.2017

    • Author(s)
      三木 厚,笠原尚哉,遠藤和洋,小泉 大,笹沼英紀,佐久間康成,堀江久永,細谷好則,北山丈二,佐田尚宏
    • Organizer
      第117回日本外科学会定期学術集会
    • Data Source
      KAKENHI-PROJECT-17K10712
  • [Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2016

    • Author(s)
      笠原 尚哉, 寺谷 工, 横田 真一郎, 三木 厚, 浦橋 泰然, 藤本 康弘, 佐久間 康成, 佐田 尚宏
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      徳島県徳島市あわぎんホール
    • Year and Date
      2016-07-14
    • Data Source
      KAKENHI-PROJECT-26461926
  • [Presentation] 笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和:短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015

    • Author(s)
      笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    • Organizer
      第101回日本消化器病学会総会
    • Place of Presentation
      仙台市
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-26461926
  • [Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2015

    • Author(s)
      笠原 尚哉, 寺谷 工, 三木 厚, 佐久間 康成, 藤本 康弘, 上本 伸二, 佐田 尚宏, 安田 是和
    • Organizer
      第70回日本消化器外科学会総会
    • Place of Presentation
      浜松市
    • Year and Date
      2015-07-15
    • Data Source
      KAKENHI-PROJECT-26461926
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  • 2.  Sata Naohiro (20261977)
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