SAKUMA YASUNARU 佐久間康成

Researcher Number	10296105
Other IDs	https://orcid.org/0000-0003-3633-3221
Affiliation (Current)	2025: 自治医科大学, 医学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 自治医科大学, 医学部, 教授 2014 – 2018: 自治医科大学, 医学部, 准教授
Review Section/Research Field	Principal Investigator Basic Section 55010:General surgery and pediatric surgery-related / General surgery Except Principal Investigator Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields / Basic Section 55010:General surgery and pediatric surgery-related / General surgery / Basic Section 55020:Digestive surgery-related / Basic Section 55050:Anesthesiology-related / Basic Section 50020:Tumor diagnostics and therapeutics-related / Basic Section 56030:Urology-related / Digestive surgery
Keywords	Principal Investigator 病態解明 / 早期診断 / 小児肝疾患 / 質量分析イメージング法 / 質量分析イメージング / 網羅歴メタボローム解析 / 胆汁酸分析 / NASH / 肥満 / 脂肪肝 … More / 褐色脂肪 / 非アルコール性脂肪肝炎 / 肥満治療 / 脂肪幹細胞 / 褐色細胞腫 / 細胞移植 / 表面マーカー / 褐色脂肪細胞 … More Except Principal Investigator メタボローム解析 / 腸管不全関連肝障害 / ポリアミン / 短腸症 / 悪液質 / オステオペニア / 骨密度 / 体組成変化 / 癌患者 / 悪性度 / 質量分析 / 体液 / がん診断 / 薬物血中濃度 / 網羅的メタボローム解析 / 術後悪心嘔吐 / 組織Q-FISH法 / 線維化マーカー / 細胞老化関連マーカー / 小児肝移植 / テロメア / フェロトーシス / 化学放射線療法耐性 / 直腸癌 / 物質分析イメージング法 / 肝移植後拒絶反応 / 胆汁 / 拒絶反応 / 直接イオン化法 / 骨髄前駆細胞 / 前転移ニッチ / 癌転移 / 好中球 / 腹膜播種 / 肺転移 / エクソソーム / 好中球細胞外トラップ / 薬物動態 / タクロリムス腎症 / メタボローム / 臓器移植 / 腎移植 / 腎症 / タクロリムス / 術後補助療法 / 個別化治療 / 副作用発現因子 / 効果予測因子 / 予後因子 / マイクロＲＮＡ / 化学療法 / 膵癌 / マイクロRNA / ＩｇA / 腸管不全合併肝障害 / 腸内細菌 / タイトジャンクション / IgA / 脂肪肝 / 小腸不全関連肝障害 / 腸管免疫 Less

Prognostic biomarkers of allograft in pediatric liver transplantation
- Principal Investigator
  
  眞田幸弘
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Jichi Medical University
Posthepatectomy Fentanyl Blood Levels and Comprehensive Metabolome Analysis of PONV Risk Factors
- Principal Investigator
  
  竹内護
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55050:Anesthesiology-related
- Research Institution
  Jichi Medical University
Development of novel cancer diagnosis system using innovative ionization mass spectrometry using body fluid samples
- Principal Investigator
  
  佐田尚宏
- Project Period (FY)
  2023 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Jichi Medical University
体組成変化と大腸癌肝転移の転移機構の解明と新規治療戦略の開発
- Principal Investigator
  
  三木厚
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55020:Digestive surgery-related
- Research Institution
  Jichi Medical University
化学放射線療法耐性直腸癌に対するフェロトーシス誘導療法の開発
- Principal Investigator
  
  井上賢之
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 50020:Tumor diagnostics and therapeutics-related
- Research Institution
  Jichi Medical University
Early Diagnosis and Pathophysiology of Pediatric Liver Disease by Bile Acid Analysis and Mass Spectrometry ImagingPrincipal Investigator
- Principal Investigator
  
  佐久間康成
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Jichi Medical University
Analysis of the pathogenesis of tacrolimus nephropathy by integrating drug distribution kinetics in renal tissue and metabolomic analysis
- Principal Investigator
  
  Iwami Daiki
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 56030:Urology-related
- Research Institution
  Jichi Medical University
Significance of neutrophil extracellular traps in the formation of pre-metastatic niches by exosomes
- Principal Investigator
  
  Onishi Yasuharu
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 55010:General surgery and pediatric surgery-related
- Research Institution
  Jichi Medical University
肝移植後拒絶反応の病態解明と直接イオン化法による革新的迅速診断法の開発
- Principal Investigator
  
  平田雄大
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Review Section
  
  Medium-sized Section 55:Surgery of the organs maintaining homeostasis and related fields
- Research Institution
  Jichi Medical University
Dietary spermidine and spermine intake strengthen intestine barrier and prevent hepatocyte lipid droplet deposition in rodent short bowel syndrome model
- Principal Investigator
  
  Kasahara Naoya
- Project Period (FY)
  2017 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University
Study for therapeutic strategy of pancreatic cancer using microRNA expresssion profiles
- Principal Investigator
  
  Sata Naohiro
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Digestive surgery
- Research Institution
  Jichi Medical University
Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissuePrincipal Investigator
- Principal Investigator
  
  SAKUMA YASUNARU
- Project Period (FY)
  2014 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University
Oral administration of polyamines promote adaptation in rodent model of short bowel syndrome
- Principal Investigator
  
  Kasahara Naoya
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  General surgery
- Research Institution
  Jichi Medical University

All 2023 2022 2019 2018 2017 2016 2015 2014

All Journal Article Presentation

[Journal Article] Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma.2023
- Author(s)
  Miki A, Sakuma Y, Watanabe J, Endo K, Sasanuma H, Teratani T, Lefor AK, Kitayama J, Sata N.
- Journal Title
  
  Current Oncology
  
  Volume: 30(2) Issue: 2 Pages: 1860-1868
- DOI
  10.3390/curroncol30020144
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08139, KAKENHI-PROJECT-23K24411
[Journal Article] Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy2023
- Author(s)
  Miki A, Sakuma Y, Watanabe J, Endo K, Sasanuma H, Teratani T, Lefor AK, Shimizu A, Kitayama J, Yasuda Y, Sata N.
- Journal Title
  
  Scientific Reports
  
  Volume: 13(1) Issue: 1 Pages: 15637-15637
- DOI
  10.1038/s41598-023-42929-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-23K08139
[Journal Article] COMPLEMENTARY INDICATORS FOR DIAGNOSIS OF HEPATIC VEIN STENOSIS AFTER PEDIATRIC LIVING DONOR LIVER TRANSPLANTATION2016
- Author(s)
  Kawano Youichi
- Journal Title
  
  Transplantation Proceedings
  
  Volume: S0041 Issue: 4 Pages: 234-237
- DOI
  10.1016/j.transproceed.2015.12.114
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-24592013, KAKENHI-PROJECT-26461925
[Journal Article] Clinical characteristics and outcomes of adenovirus infection of the urinary tract after renal transplantation.2016
- Author(s)
  Nanmoku K, Ishikawa N, Kurosawa A, Shimizu T, Kimura T, Miki A, Sakuma Y, Yagisawa T
- Journal Title
  
  Transpl Infect Dis
  
  Volume: 18 Issue: 2 Pages: 234-239
- DOI
  10.1111/tid.12519
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461925
[Journal Article] The outcomes of pediatric living donor liver transplantation using small-for-size grafts: experience of a single institute.2016
- Author(s)
  Yamada N, Sanada Y, Hirata Y, Okada N, Ihara Y, Sasanuma H, Urahashi T, Sakuma Y, Yasuda Y, Mizuta K
- Journal Title
  
  Pediatr Surg Int.
  
  Volume: 19 Issue: 4 Pages: 363-368
- DOI
  10.1007/s00383-016-3859-4
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461925
[Journal Article] Pediatric living donor liver transplantation for congenital hepatic fibrosis using a mother's graft with von Meyenburg complex: A case report.2016
- Author(s)
  Yamada N, Sanada Y, Katano T, Tashiro M, Hirata Y, Okada N, Ihara Y, Miki A, Sasanuma H, Urahashi T, Sakuma Y, Mizuta K.
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22 Pages: 9865-9870
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461925
[Journal Article] Immunohistochemical evaluation for outflow reconstruction using opened round ligament in living donor right posterior sector graft liver transplantation: A case report.2016
- Author(s)
  Sanada Y
- Journal Title
  
  World J Gastroenterol
  
  Volume: 22(34) Issue: 34 Pages: 7851-6
- DOI
  10.3748/wjg.v22.i34.7851
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
[Journal Article] Living-Donor Liver Transplantation Using Segment 2 Monosegment Graft: A Single-Center Experience.2016
- Author(s)
  Sakuma Y
- Journal Title
  
  Transplant Proc
  
  Volume: 48(4) Issue: 4 Pages: 1110-4
- DOI
  10.1016/j.transproceed.2015.12.119
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
[Journal Article] Selection of living donor liver grafts for patients weighing 6kg or less2015
- Author(s)
  Naoya Yamada
- Journal Title
  
  Liver Transplantation
  
  Volume: 21(2) Issue: 2 Pages: 233-238
- DOI
  10.1002/lt.24048
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
[Journal Article] The impact of rituximab in ABOincompatible pediatric living donor liver transplantation: The experience of a single center2015
- Author(s)
  Noriki Okada, Yukihiro Sanada, Yuta Hirata, Naoya Yamada, Taiichi Wakiya, Yoshiyuki Ihara, Taizen Urahashi, Atsushi Miki, Yuji Kaneda, Hideki Sasanuma, Takehito Fujiwara, Yasunaru Sakuma, Atsushi Shimizu, Masanobu Hyodo, Yoshikazu Yasuda, Koichi Mizuta
- Journal Title
  
  Pediatric Transplantation
  
  Volume: 19 Issue: 3 Pages: 279-286
- DOI
  10.1111/petr.12445
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461925
[Journal Article] Improved human islet preparations using glucocorticoid and exendin-42014
- Author(s)
  Atsushi Miki
- Journal Title
  
  Pancreas
  
  Volume: 43(8) Issue: 8 Pages: 1317-1322
- DOI
  10.1097/mpa.0000000000000184
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-25870665, KAKENHI-PROJECT-26461925
[Journal Article] Risk Factors of Cytomegalovirus Infection After Pediatric Liver Transplantation2014
- Author(s)
  Y. Kawano, K. Mizuta, Y. Sanada, T. Urahashi, Y. Ihara, N. Okada, N. Yamada, H. Sasanuma, Y. Sakuma, N. Taniai, H. Yoshida, H. Kawarasaki, Y. Yasuda, and E. Uchida
- Journal Title
  
  Transplantation Proceedings
  
  Volume: 46 Issue: 10 Pages: 3543-3547
- DOI
  10.1016/j.transproceed.2014.09.150
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-26461925
[Presentation] 【肝胆膵】消化器移植医療の現状と今後の展望　チーム医療による肝移植の現状と今後の展望2022
- Author(s)
  大西康晴, 佐久間康成, 眞田幸弘, 岡田憲樹, 平田雄大, 堀内俊男, 大豆生田尚彦, 水田耕一, 佐田尚宏.
- Organizer
  第77回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-21K08602
[Presentation] 切除不能膵頭部腫瘍による総胆管閉塞に対し、胃空腸バイパス術と胆道ステント留置を併施した一例2019
- Author(s)
  窪木　大悟, 笹沼　英紀, 橋本　雄介, 三木　厚, 吉田　淳, 森嶋　計, 遠藤　和洋, 佐久間　康成, 堀江　久永, 細谷　好則, 北山　丈二, 佐田　尚宏
- Organizer
  第55回日本胆道学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] Telomere長解析によるIPMN多段階発癌解析と悪性度診断2019
- Author(s)
  三木　厚, 相田　順子, 森嶋　計, 遠藤　和洋, 吉田　淳, 笹沼　英紀, 佐久間　康成, 山口博紀, 田久保　海誉, 堀江　久永, 味村　俊樹, 細谷　好則, 福島　敬宜, 北山　丈二, 佐田　尚宏
- Organizer
  第24回日本外科病理学会学術集会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 12年の長期経過観察中に悪性化したと考えられる膵粘液嚢胞性腫瘍の一例2019
- Author(s)
  高橋　礼, 笹沼　英紀, 三木　厚, 森嶋　計, 吉田　淳, 遠藤　和洋, 佐久間　康成, 堀江　久永, 細谷　好則, 北山　丈二, 佐田　尚宏, 池田　恵理子, 福島敬宜
- Organizer
  第354回日本消化器病学会関東支部例会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 腹腔鏡下膵体尾部切除(Lap-DP)における定型化膵離断　膵臓の厚みとカートリッジに関する検討2018
- Author(s)
  笹沼英紀, 佐久間康成, 木村有希, 青木裕一, 田口昌延, 森嶋計, 遠藤和洋, 吉田淳, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第31回日本内視鏡外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 膵体尾部切除術における膵断端処理と術後膵液瘻の検討2018
- Author(s)
  木村有希, 小泉大, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第73回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 慢性膵炎急性増悪を契機に脾膿瘍を合併した1例2018
- Author(s)
  寺田茉位子, 吉田淳, 佐久間康成, 木村有希, 青木裕一, 森嶋計, 遠藤和洋, 笹沼英紀, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第80回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 膵頭部癌に対して膵頭十二指腸切除術を施行し膵尾側断端閉鎖を行った一例2018
- Author(s)
  倉田佳彦, 木村有希, 青木裕一, 森嶋計, 遠藤和洋, 笹沼英紀, 吉田淳, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第80回日本臨床外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 膵頭十二指腸切除術を施行した十二指腸乳頭部癌の長期成績2018
- Author(s)
  小泉大, 齋藤晶, 横田真一郎, 兼田裕司, 三木厚, 遠藤和洋, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第118回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 膵頭部残膵再発に対して、初回左胃動脈温存が有用であった膵内分泌癌の再手術例2018
- Author(s)
  泉遼, 遠藤和洋, 齋藤晶, 田口昌延, 三木厚, 小泉大, 笹沼英紀, 佐久間康成, 堀江久永, 細谷好則, 北山丈二, 佐田尚宏
- Organizer
  第49回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 切除可能膵癌に対する術前化学放射線治療の有用性．2017
- Author(s)
  三木　厚，佐久間康成，笠原尚哉，遠藤和洋，小泉　大，笹沼英紀，堀江久永，細谷好則，北山丈二，佐田尚宏
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 十二指腸腫瘍性病変に対する膵温存十二指腸切除術の治療成績．2017
- Author(s)
  齋藤　晶，小泉　大，三木　厚，遠藤和洋，笹沼英紀，佐久間康成，堀江久永，細谷好則，北山丈二，佐田尚宏
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 当科における膵IPMNの手術術式の検討．2017
- Author(s)
  齋藤　匠，三木　厚，笠原尚哉，遠藤和洋，小泉　大，笹沼英紀，佐久間康成，堀江久永，細谷好則，北山丈二，佐田尚宏
- Organizer
  第48回日本膵臓学会大会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 当科における膵IPMNの縮小手術の検討．2017
- Author(s)
  齋藤　匠，三木　厚，遠藤和洋，小泉　大，笹沼英紀，佐久間康成，堀江久永，細谷好則，北山丈二，佐田尚宏
- Organizer
  第72回日本消化器外科学会総会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] IPMN国際診療ガイドラインからみた当院でのIPMN手術例の検討．2017
- Author(s)
  三木　厚，笠原尚哉，遠藤和洋，小泉　大，笹沼英紀，佐久間康成，堀江久永，細谷好則，北山丈二，佐田尚宏
- Organizer
  第117回日本外科学会定期学術集会
- Data Source
  KAKENHI-PROJECT-17K10712
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2016
- Author(s)
  笠原尚哉, 寺谷工, 横田真一郎, 三木厚, 浦橋泰然, 藤本康弘, 佐久間康成, 佐田尚宏
- Organizer
  第71回日本消化器外科学会総会
- Place of Presentation
  徳島県徳島市あわぎんホール
- Year and Date
  2016-07-14
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和：短腸症モデルラットを用いたポリアミン摂取による治療効果の検討2015
- Author(s)
  笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和
- Organizer
  第101回日本消化器病学会総会
- Place of Presentation
  仙台市
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-26461926
[Presentation] 短腸症モデルラットを用いたポリアミン摂取による治療効果の検討と小腸再生促進メカニズムの解明2015
- Author(s)
  笠原尚哉, 寺谷工, 三木厚, 佐久間康成, 藤本康弘, 上本伸二, 佐田尚宏, 安田是和
- Organizer
  第70回日本消化器外科学会総会
- Place of Presentation
  浜松市
- Year and Date
  2015-07-15
- Data Source
  KAKENHI-PROJECT-26461926

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# of Collaborated Products: 5 results
2. Sata Naohiro (20261977)

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43. 木村有希 (30721609)

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44. KAWANO Yoichi

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

SAKUMA YASUNARU 佐久間 康成

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Early Diagnosis and Pathophysiology of Pediatric Liver Disease by Bile Acid Analysis and Mass Spectrometry ImagingPrincipal Investigator

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Novel treatment for non-alcoholic hepatitis inducing human brown adipose tissuePrincipal Investigator

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[Journal Article] Osteopenia Is Associated with Shorter Survival in Patients with Intrahepatic Cholangiocarcinoma.2023

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[Journal Article] Remnant liver function is associated with long-term survival in patients with hepatocellular carcinoma undergoing hepatectomy2023

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SAKUMA YASUNARU 佐久間康成

[Presentation] 【肝胆膵】消化器移植医療の現状と今後の展望　チーム医療による肝移植の現状と今後の展望2022