Niikura Takako 新倉貴子

… Alternative Names

NIIKURA Takako 新倉貴子

Less

Researcher Number	10301491
Other IDs
Affiliation (Current)	2025: 上智大学, 理工学部, 教授
Affiliation (based on the past Project Information) *help	2019 – 2024: 上智大学, 理工学部, 教授 2017 – 2018: 上智大学, 理工学部, 准教授 2012 – 2014: 上智大学, 理工学部, 准教授 2007: 慶應大, 医学部, 助手 1998 – 2006: 慶應義塾大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology / Basic Section 37020:Chemistry and chemical methodology of biomolecules-related / Neurology Except Principal Investigator Neurology / Neurology / Brain sciences and related fields / Psychiatric science / General physiology
Keywords	Principal Investigator 生理活性分子 / アルツハイマー病 / ペプチド / 神経細胞死 / 老化 / neuronal death / alsin / ALS2 / アミロイドベータ / カスペース … More / 細胞老化 / 生物活性分子 / 認知機能 / 神経伝達物質 / amyloid beta / peptide derivative / peptide / neuronrotective factor / Humanin / Alzheimer's disease / ペプチド誘導体 / 細胞死抑制因子 / ヒューマニン(Humanin) / superoxide dismutase / amyotrophic lateral sclerosis / neurodegenerative disease / Alsin / スーパーオキシドジスムターゼ / スーパーオキシドジスムタ / 筋萎縮性側索硬化症 / 神経変性疾患 / 脳神経疾患 / シグナル伝達 / 抗酸化剤 / アミロイド前駆体蛋白質 / TRIM11 / ヒューマニン / c-Jun N-terminal kinase / プレセニリン / アミロイド前駆体蛋白 / 細胞死 … More Except Principal Investigator アルツハイマー病 / ノックイン / 神経細胞死 / SOD1 / RAP / LRP / アミロイドβ / アクアポリン４ / 疾患モデル / 分化誘導 / ES細胞 / ApoE4 / 遺伝子ターゲティング / 神経変性疾患 / 老化 / 認知症 / 遺伝子 / 神経科学 / 脳神経疾患 / 脳リンパ排泄機構 / 動物モデル / 脳アミロイド血管症 / spinal motor neurons / differentiation / disease model / amyotrophic lateral sclerosis / embryonic stem cell / ALS / 運動ニューロン / 病態モデル / 筋萎縮性側索硬化症 / receptor / serine isomerase / dimerization / neurodegenerative disease / Alzheimer's disease / Humanin / βFGF / IGF-I / 生体内発現 / ADNF / bFGF / IGF-1 / 分泌機構 / 構造機能相関 / HN / Apolipoprotein E3 / α2-macroglobullin / Neuronal Death / Apolipoprotein E4 / 細胞死抑制 / ApoE3 / α2マクログロブリン / 遺伝子改変マウス / タウ / マウスモデル / ミクログリア / アストロサイト / 神経細胞 / 疾患モデルマウス / Cre-loxP / V642I点変異 / APP / αサブユニット / αシヌクレイン / 細胞死 / アミロイド前駆体蛋白 Less

アルツハイマー病病態改善ペプチド因子の脳における抗老化作用とその分子機構Principal Investigator
- Principal Investigator
  
  新倉貴子
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Sophia University
Anti-aging effects of a peptide factor that modifies Alzheimer's disease pathologiesPrincipal Investigator
- Principal Investigator
  
  Niikura Takako
- Project Period (FY)
  2021 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Sophia University
The role of a cytoprotective peptide factor against Alzheimer's disease pathologies in anti-brain agingPrincipal Investigator
- Principal Investigator
  
  NIIKURA Takako
- Project Period (FY)
  2018 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 37020:Chemistry and chemical methodology of biomolecules-related
- Research Institution
  Sophia University
Elucidation of pathomechanism of Alzheimer's disease focusing on AQP4 function and lymphatic drainage system in the brain.
- Principal Investigator
  
  Abe Yoichiro
- Project Period (FY)
  2017 – 2018
- Research Category
  
  Grant-in-Aid for Challenging Research (Exploratory)
- Research Field
  
  Brain sciences and related fields
- Research Institution
  Keio University
Investigation of an underlying mechanism of progression from accumulation of Abeta to neurofibrillary tangle formation using Alzheimer's model mice
- Principal Investigator
  
  ABE Yoichiro
- Project Period (FY)
  2013 – 2014
- Research Category
  
  Grant-in-Aid for Challenging Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University
Molecular mechanisms of amyloid beta metabolism by a cell survival factorPrincipal Investigator
- Principal Investigator
  
  NIIKURA Takako
- Project Period (FY)
  2012 – 2013
- Research Category
  
  Grant-in-Aid for Research Activity Start-up
- Research Field
  
  Neurology
- Research Institution
  Sophia University
ヒューマニンの時間依存的作用と標的への移行様式に着目した神経保護機構の解析Principal Investigator
- Principal Investigator
  
  新倉貴子
- Project Period (FY)
  2007
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
Functional analysis of neuroprotective factor Humanin as a basis for Alzheimer's disease therapyPrincipal Investigator
- Principal Investigator
  
  NIIKURA Takako
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
Establishment and analysis aria vitro model neurons lifaLEVEed from transgenic ES cells, in which a FALS-linked mutant SOD1 is introduced
- Principal Investigator
  
  ABE Yokbiro
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
Elucidation of mechanisms for neuronal death caused by mutant genes in amyotrophic lateral sclerosisPrincipal Investigator
- Principal Investigator
  
  NIIKURA Takako
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Keio University
アミロイド前駆体蛋白の変異導入ES細胞を用いたアルツハイマー病神経細胞の確立
- Principal Investigator
  
  ABE Yoichiro
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University
アルツハイマー病原因遺伝子による神経細胞死誘導機序の総合的解析Principal Investigator
- Principal Investigator
  
  新倉貴子
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Keio University
新規のAPP変異ノックインマウスを用いたアルツハイマー病発症関連遺伝子の探索
- Principal Investigator
  
  神山圭介
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University
Detailed characterization of Humanin, a newly identified anti-Alzheimer's disease peptide and potential starting point for development of the first curative therapy for Alzheimer's disease
- Principal Investigator
  
  NISHIMOTO Ikuo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  KEIO UNIVERSITY
神経細胞におけるアミロイド前駆体蛋白とαシヌクレインの機能の解析
- Principal Investigator
  
  YAMOCHI Tadanori
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University
ApoE4の誘導する神経細胞死機構の萌芽的研究
- Principal Investigator
  
  松岡正明
- Project Period (FY)
  1999
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Psychiatric science
- Research Institution
  Keio University
Elucidation of the principal mechanism for dementia and identification of anti-dementia genes through the analysis of ApoE4 neurotoxicity
- Principal Investigator
  
  NISHIMOTO Ikuo
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
神経細胞死の分子生物学的解析法の確立と、神経変性疾患遺伝子による神経細胞死の研究Principal Investigator
- Principal Investigator
  
  新倉貴子
- Project Period (FY)
  1998 – 1999
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Neurology
- Research Institution
  Keio University
神経細胞における正常及び異常アミロイド前駆体蛋白のシグナル伝達機能の解析
- Principal Investigator
  
  紅江
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  General physiology
- Research Institution
  Keio University
ノックインを用いた新しい遺伝子組換え戦略によるアルツハイマー病モデルマウスの開発
- Principal Investigator
  
  福田亨
- Project Period (FY)
  1998
- Research Category
  
  Grant-in-Aid for Exploratory Research
- Research Field
  
  Neurology
- Research Institution
  Keio University

All 2023 2022 2021 2019 2018 2017 2013 2012 2007 2006 2005 2004 2003 Other

All Journal Article Presentation Book

[Book] Frontiers in Alzheimer's Disease Research2006
- Author(s)
  Welsh, Eileen M.(Ed.), Niikura T, Nishimoto I.
- Publisher
  Nova Science Publishers(In press)
- Data Source
  KAKENHI-PROJECT-17590894
[Book] Frontiers in Alzheimer's Disease Research2006
- Author(s)
  Welshi, Eileen M.(Ed.), Niikura T, Nishimoto I.
- Publisher
  Nove Science Publishers
- Data Source
  KAKENHI-PROJECT-17590894
[Book] Frontiers in Alzheimer's Disease Research2006
- Author(s)
  Welsh, Eileen M.(Ed.) Niikura T, Nishimoto I.
- Publisher
  Nova Science Publishers
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Humanin and Alzheimer's disease: The beginning of a new field2022
- Author(s)
  Niikura Takako
- Journal Title
  
  Biochimica et Biophysica Acta (BBA) - General Subjects
  
  Volume: 1866 Issue: 1 Pages: 130024-130024
- DOI
  10.1016/j.bbagen.2021.130024
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K05342, KAKENHI-PROJECT-21K05296
[Journal Article] SENP1 and SENP2 regulate SUMOylation of amyloid precursor protein.2018
- Author(s)
  Maruyama T, Abe Y, and Niikura T.
- Journal Title
  
  Heliyon
  
  Volume: 4 Issue: 4 Pages: e00601-e00601
- DOI
  10.1016/j.heliyon.2018.e00601
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-17K19637
[Journal Article] Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults.2018
- Author(s)
  Maruyama T, Wada H, Abe Y, Niikura T.
- Journal Title
  
  Biochem. Biophys. Res. Commun.
  
  Volume: 500 Issue: 2 Pages: 470-475
- DOI
  10.1016/j.bbrc.2018.04.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19637
[Journal Article] Humanin affects object recognition and gliosis in short-term cuprizone-treated mice.2017
- Author(s)
  Murakami M, Nagahama M, Abe Y, Niikura T.
- Journal Title
  
  Neuropeptides
  
  Volume: 66 Pages: 90-96
- DOI
  10.1016/j.npep.2017.10.002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K19637
[Journal Article] Structure analysis of Activity-dependent neurotrophic factor 9 by circular dichroism and sedimentation equilibrium2007
- Author(s)
  Arakawa T, Niikura T, Tajima H, Arisaka F, Kita Y.
- Journal Title
  
  J.Mol.Neurosci. (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Structure analysis of Activity-dependent neurotrophic factor 9 by circular dichroism and sedimentation equilibrium.2007
- Author(s)
  Arakawa T, Niikura T, Tajima H, Arisaka F, Kita Y.
- Journal Title
  
  J. Mol. Neurosci. (In press)
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Structure analysis of Activity-dependent neurotrophic factor 9 by circular dichroism and sedimentation equilibrium.2007
- Author(s)
  Arakawa T, Niikura T, Tajima H, Arisaka F, Kita Y.
- Journal Title
  
  J. Mol. Neurosci. (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] NK4, an antagonist of hepatocyte growth factor(HGF), inhibits growth of multiple myeloma cells in vivo ; molecular targeting of angiogenic growth factor2007
- Author(s)
  Du W, Hattori Y, Yamada T, Matsumoto K, Nakamura T, Sagawa M, Otsuki T, Niikura T, Nukiwa T, Ikeda Y.
- Journal Title
  
  Blood 109
  
  Pages: 3042-3049
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] The secondary structure analysis of a potent Ser14Gly analog of anti-Alzheimer peptide,Humanin,by circular dichrosim2007
- Author(s)
  Arakawa T, Niikura T, Tajima H, Kita Y.
- Journal Title
  
  J.Peptide Sci. 12
  
  Pages: 639-642
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Humanin,a potential peptide for neuroprotective therapy against Alzheimer's disease2007
- Author(s)
  Niikura T
- Journal Title
  
  Expert Opinion on Drug Discovery (In press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] NK4,an antagonist of hepatocyte growth factor(HGF),inhibits growth of multiple myeloma cells in vivo;molecular targeting of angiogenic growth factor2007
- Author(s)
  Du W, Hattori Y, Yamada T, Matsumoto K, Nakamura T, Sagawa M, Otsuki T, Niikura T, et. al.
- Journal Title
  
  Blood 109
  
  Pages: 3042-3049
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] NK4, an antagonist of hepatocyte growth factor (HGF) inhibits growth of multiple myeloma cells in vivo; molecular targeting of angiogenic growth factor2007
- Author(s)
  Du W, Hattori Y, Yamada T, Matsumoto K, Nakamura T, Sagawa M, Otsuki T, Niikura T, et al.
- Journal Title
  
  Blood 109
  
  Pages: 3042-3049
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Neuronal cell death in Alzheimer's disease and a neuroprotective factor, Humanin2006
- Author(s)
  Niikura T #, Tajima T, Kita Y.
- Journal Title
  
  Current Neuropharmacology 4
  
  Pages: 139-147
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Neuronal cell death in Alzheimer's disease and a neuroprotective factor, Humanin.2006
- Author(s)
  Niikura T, Tajima T, Kita Y.
- Journal Title
  
  Current Neuropharmacology 4
  
  Pages: 139-147
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Neuronal cell death in alzheimer's disease and a neuroprotective factor,Humanin2006
- Author(s)
  Niikura T, Tajima T, Kita Y.
- Journal Title
  
  Current Neuropharmacology 4
  
  Pages: 139-147
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] The secondary structure analysis of a potent Ser14Gly analog of anti-Alzheimer peptide, Humanin, by circular dichroism.2006
- Author(s)
  Arakawa T, Niikura T, Tajima H, Kita Y.
- Journal Title
  
  J. Peptide Sci. 12
  
  Pages: 639-642
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] The secondary structure analysis of a potent Serl4Gly analog of anti-Alzheimer peptide, Humanin, by circular dichroism.2006
- Author(s)
  Arakawa, T, Niikura T, Tajima H, Kita Y.
- Journal Title
  
  J. Peptide Sci. 12
  
  Pages: 639-642
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Expression of N19S-SOD1, a SOD1 mutant found in sporadic amyotrophic lateral sclerosis (ALS) patients, induces low-grade motoneuronal toxicity.2005
- Author(s)
  Obata Y, Niikura T, et al.
- Journal Title
  
  J.Neurosci.Res. 81(5)
  
  Pages: 720-729
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection2005
- Author(s)
  Hashimoto Y, Suzuki H, Aiso S, Niikura T, et. al.
- Journal Title
  
  Life Sciences 77(24)
  
  Pages: 3092-3104
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection2005
- Author(s)
  Hashimoto Y, Suzuki H, Aiso S, Niikura T, Nishimoto I, Matsuoka M.
- Journal Title
  
  Life Sciences 77
  
  Pages: 3092-3104
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Implanted cannula-mediated repetitive administration of Ab25-35 into them ouse cerebral ventricle effectively impairs spatial working memory.2005
- Author(s)
  Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, et al.
- Journal Title
  
  Behavioural Brain Research 162(2)
  
  Pages: 714-723
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Expression of N19S-SOD1, a SOD1 mutant found in sporadic amyotrophic lateral sclerosis(ALS) patients, induces low-grade motoneuronal toxicity.2005
- Author(s)
  Obata Y, Niikura T, Kanekura K, Hashimoto Y, Kawasumi M, Kita Y, Aiso S, Matsuoka M, Nishimoto I.
- Journal Title
  
  J. Neurosci. Res. 81
  
  Pages: 720-729
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] A Humanin derivative, S14G-HN, prevents amyloid-β-induced memory impairment in mice.2005
- Author(s)
  Tajima H, Kawasumi M, Chiba T, Yamada M, Yamashita K, Nawa M, Kita Y, Kouyama K, Aiso S, Matsuoka M, Niikura T, Nishimoto I.
- Journal Title
  
  J.Neurosci.Res. 79(5)
  
  Pages: 714-723
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection.2005
- Author(s)
  Hashimoto Y, Suzuki H, Aiso S, Niikura T, et al.
- Journal Title
  
  Life Sciences 77(24)
  
  Pages: 3092-3104
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Neuroprotective effect of activity-dependent neurotrophic factor, ADNF, against toxicity by familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo.2005
- Author(s)
  Chiba T, Hashimoto Y, Tajima H, Yamada M, Kato R, Niikura T, Terashita K, Schulman H, Aiso S, Kita Y, Matsuoka M, Nishimoto I.
- Journal Title
  
  J.Neurosci.Res. 78(4)
  
  Pages: 542-552
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Molecular characterization of neuronal cell death by Alzheimer's amyloid-b peptides via D75NTR/PLAIDD.2004
- Author(s)
  Hashimoto Y, Kaneko Y, Tsukamoto E, Frankowski H, Kouyama K, Kita Y, Niikura T, Aiso S, Bredesen DE, Matsuoka M, Nishimoto I.
- Journal Title
  
  J.Neurochem. 90(3)
  
  Pages: 549-558
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Characterization of V642I-AβPP-induced cytotoxicity in primary neurons.2004
- Author(s)
  Niikura T., et al.
- Journal Title
  
  J.Neurosci.Res. 77
  
  Pages: 54-62
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Characterization of V6421-APP-induced cytotoxicity in primary neurons.2004
- Author(s)
  Niikura T, Yamada M, Chiba T, Also S, Matsuoka M, Nishimoto I.
- Journal Title
  
  J.Neurosci.Res. 77(1)
  
  Pages: 54-62
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Humanin antagonists : mutants that interfere with dimerization inhibit neuroproteiction by Humanin.2004
- Author(s)
  Hashimoto Y, Terashita K, Niikura T, Yamagishi Y, Ishizaka M, Kanekura K, Chiba T, Yamada M, Kita Y, Aiso S, Matsuoka M#, Nishimoto I.
- Journal Title
  
  Eur.J.Neurosci. 19(9)
  
  Pages: 2356-2364
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Humanin, after the discovery.2004
- Author(s)
  Niikura T, Chiba T, Aiso S.Matsuoka M, Nishimoto I.
- Journal Title
  
  Mol Neurobiol. 30(3)
  
  Pages: 327-340
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] The Gtx homeodomain transcription factor exerts neuroprotection using its homeodomain.2004
- Author(s)
  Hashimoto Y, Tsuji O, Kanekura K, Aiso S, Niikura T, Matsuoka M#, Nishimoto I.
- Journal Title
  
  J.Biol.Chem. 279(16)
  
  Pages: 16767-16777
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] The amino- and carboxyl-terminal mutants of presenilin 1 cause neuronal cell death through different neurotoxic mechanisms.2004
- Author(s)
  Hashimoto Y, Tsukamoto E, Niikura T, Yamagishi Y, Ishizaka M, Also S, Takashima A, Nishimoto I.
- Journal Title
  
  J.Neurosci.Res. 75(3)
  
  Pages: 417-428
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Humanin : after the discovery.2004
- Author(s)
  Niikura T., et al.
- Journal Title
  
  Mol Neurobiol 30
  
  Pages: 327-340
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Cytotoxic mechanisms by M239V presenilin 2, a little-analyzed Alzheimers disease-causative mutant.2004
- Author(s)
  Abe Y, Hashimoto Y, Tomita Y, Terashita K, Aiso S.Tajima H, Niikura T, Matsuoka M, Nishimoto I.
- Journal Title
  
  J Neurosci Res. 77(4)
  
  Pages: 583-595
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Characterization of V642I-APP-induced cytotoxicity in primary neurons.2004
- Author(s)
  Niikura T., et al.
- Journal Title
  
  J.Neurosci.Res. 77(1)
  
  Pages: 54-62
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Unraveling the role of Humanin.2004
- Author(s)
  Nishimoto I, Matsuoka M, Niikura T.
- Journal Title
  
  Trends Mol.Med. 10(3)
  
  Pages: 102-106
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Humanin and Alzheimer's disease.2004
- Author(s)
  Niikura T, Aiso S, Matsuoka M, Nishimoto I.
- Journal Title
  
  Alzheimer Actualites 176
  
  Pages: 6-9
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Alsin, the product of ALS2 gene, suppresses SOD1 mutant neurotoxicity through RhoGEF domain by interacting with SOD1 mutants.2004
- Author(s)
  Kanekura K, Hashimoto Y, Niikura T, Aiso S, Matsuoka M#, Nishimoto I.
- Journal Title
  
  J.Biol.Chem. 279(18)
  
  Pages: 19247-19256
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Humanin and Atzheimer's disease.2004
- Author(s)
  Niikura T., et al.
- Journal Title
  
  Alzheimer Actualites 176
  
  Pages: 6-9
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] Analysis of neurons created from wild-type and Alzheimer's mutation knock-in embryonic stem cells by a highly efficient differentiation protocol.2004
- Author(s)
  Abe Y, Kouyama K, Tomita T, Tomita Y, Ban N, Nawa M, Matsuoka M, Niikura T, Aiso S, Kita Y, Iwatsubo T, Nishimoto I.
- Journal Title
  
  J.Nuerosci. 23(24)
  
  Pages: 8513-8525
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Journal Article] A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.2003
- Author(s)
  Niikura T., et al.
- Journal Title
  
  The European Journal of Neuroscience 17
  
  Pages: 1150-1158
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-13307022
[Journal Article] A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults.2003
- Author(s)
  Niikura T., et al.
- Journal Title
  
  The European Journal of Neuroscience 17(6)
  
  Pages: 1150-1158
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-13307022
[Journal Article] a potential peptide for neuroprotective therapy against Alzheimer's disease.
- Author(s)
  Niikura T #. Humanin
- Journal Title
  
  Expert Opinion on Drug Discovery (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-17590894
[Journal Article] Implanted cannula-mediated repetitive administration of Aβ25-35 into the mouse cerebral ventricle effectively impairs spatial working memory.
- Author(s)
  Yamada M, Chiba T, Sasabe J, Nawa M, Tajima H, Niikura T, Terashita K, Aiso S, Kita Y, Matsuoka M, Nishimoto I.
- Journal Title
  
  Behavioral Brain Research (in press)
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-15590908
[Presentation] Humanin, a bioactive peptide, suppresses cellular senescence in neurons.2023
- Author(s)
  A Kozuka, T Niikura
- Organizer
  Society for Neuroscience Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-21K05296
[Presentation] 神経細胞の細胞老化に対する生理活性ペプチド因子ヒューマニンの影響2022
- Author(s)
  Ayari Kozuma, Dan Suzuki, Takako Niikura
- Organizer
  第65回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] The effect of Humanin, a bioactive peptide, on cellular senescence in neurons.2022
- Author(s)
  A Kozuka, D Suzuki, T Niikura
- Organizer
  第６５回日本神経化学会年会
- Data Source
  KAKENHI-PROJECT-21K05296
[Presentation] 神経伝達物質放出に対する生理活性ペプチド因子ヒューマニンの影響2021
- Author(s)
  Takako Niikura, Nozomi Morita, Ayari Kozuma, Natsumi Ikegawa, Nobuyuki Sasakawa
- Organizer
  第64回日本神経化学会大会
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] Humanin, a bioactive peptide, increases hippocampal acetylcholine level in normal mice.2019
- Author(s)
  N Ikegawa, M Murakami, T Niikura
- Organizer
  Society for Neuroscience 49th Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] 生理活性ペプチドヒューマニンの抗ストレス作用2019
- Author(s)
  池川夏実，村上峰宇，新倉貴子
- Organizer
  第92回日本薬理学会年会
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] Effect of Humanin on streptozotocin-induced cognitive deficit in mice2019
- Author(s)
  T Tanaka, Y Kita , T Niikura
- Organizer
  Society for Neuroscience 49th Annual Meeting 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] Humanin increase amount of acetylcholine in the hippocampal region of mouse2019
- Author(s)
  N Ikegawa, M Murakami, T Niikura
- Organizer
  第６２回日本神経化学会年会
- Data Source
  KAKENHI-PROJECT-18K05342
[Presentation] Humanin and its derivatives activate ERK via FPRL-1 similarly despite the quite difference neuroprotective-potency between the derivatives.2013
- Author(s)
  Takako Niikura
- Organizer
  The 11th International Conference on Alzheimer’s and Parkinson’s Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24890236
[Presentation] Signaling cascades of Humanin and the derivatives through Formyl peptide receptor like-1 (FPRL-1)2013
- Author(s)
  Y Kita, T Arakawa, T Niikura
- Organizer
  Society for Neuroscience 42nd Annual Meeting
- Place of Presentation
  San Diego CA, USA
- Data Source
  KAKENHI-PROJECT-24890236
[Presentation] Humanin and its derivatives activate ERK via FPRL-1 similarly despite the quite difference neuroprotective-potency between the derivatives2013
- Author(s)
  T Niikura, T Arakawa, Y Kita
- Organizer
  The 11^<th> International Conference on Alzheimer's and Parkinson's Diseases
- Place of Presentation
  Florence, Italy
- Data Source
  KAKENHI-PROJECT-24890236
[Presentation] Signaling cascades of Humanin and the derivatives through Formyl peptide receptor like-1 (FPRL-1).2013
- Author(s)
  Y Kita, T Arakawa, T Niikura.
- Organizer
  Society for Neuroscience 42nd Annual Meeting
- Place of Presentation
  San Diego CA, USA
- Data Source
  KAKENHI-PROJECT-24890236
[Presentation] Is the difference in neuro-protective activity between Humanin analogs conserved in FPRL-1 mediated activation?2012
- Author(s)
  Y Kita, T Arakawa, T Niikura
- Organizer
  Society for Neuroscience 42nd Annual Meeting2012
- Place of Presentation
  New Orleans LA, USA
- Data Source
  KAKENHI-PROJECT-24890236

1. NISHIMOTO Ikuo (80180652)

# of Collaborated Projects: 7 results

# of Collaborated Products: 0 results
2. MATSUOKA Masaaki (70222297)

# of Collaborated Projects: 5 results

# of Collaborated Products: 0 results
3. ABE Yoichiro (10317331)

# of Collaborated Projects: 4 results

# of Collaborated Products: 3 results
4. KOUYAMA Keisuke (30296553)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
5. MATSUDA Shuji (70296721)

# of Collaborated Projects: 4 results

# of Collaborated Products: 0 results
6. YAMOCHI Tadanori (80306844)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. HASHIMOTO Yuichi (00317330)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
8. 紅江 (60296720)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
9. 福田亨 (20301492)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
10. 安川孝史 (60291936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
11. 田島裕久 (50306833)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results

Niikura Takako 新倉 貴子

NIIKURA Takako 新倉 貴子

Research Projects

Research Products

Co-Researchers

アルツハイマー病病態改善ペプチド因子の脳における抗老化作用とその分子機構Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Anti-aging effects of a peptide factor that modifies Alzheimer's disease pathologiesPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

The role of a cytoprotective peptide factor against Alzheimer's disease pathologies in anti-brain agingPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Molecular mechanisms of amyloid beta metabolism by a cell survival factorPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

ヒューマニンの時間依存的作用と標的への移行様式に着目した神経保護機構の解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Functional analysis of neuroprotective factor Humanin as a basis for Alzheimer's disease therapyPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Elucidation of mechanisms for neuronal death caused by mutant genes in amyotrophic lateral sclerosisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

アルツハイマー病原因遺伝子による神経細胞死誘導機序の総合的解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Principal Investigator

Project Period (FY)

Niikura Takako 新倉貴子

NIIKURA Takako 新倉貴子