Takaishi Mikiro 高石樹朗

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TAKAISHI Mikiro 高石樹朗

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Researcher Number	10303223
Other IDs
Affiliation (Current)	2025: 高知大学, 教育研究部医療学系臨床医学部門, 助教
Affiliation (based on the past Project Information) *help	2015 – 2023: 高知大学, 教育研究部医療学系臨床医学部門, 助教 2011 – 2014: 高知大学, 教育研究部医療学系, 助教 2009 – 2012: 高知大学, 教育研究部・医療学系, 助教 2005: 岡山大学, 大学院医歯薬学総合研究科, 助手 2001 – 2004: Graduate School of Med. & Dent., Res. Assist., 大学院・医歯学総合研究科, 助手 1999 – 2000: 富山医科薬科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology Except Principal Investigator Dermatology / Basic Section 53050:Dermatology-related / Dermatology
Keywords	Principal Investigator 表皮角化細胞 / 間葉－上皮移行 / 間葉ー上皮移行 / 細胞分化 / スプライシング異常 / 皮膚悪性腫瘍 / 腫瘍増殖制御 / 化学発がん / spliceosome / 核タンパク質 … More / 増殖・分化 / 分化 / 増殖 / スプライシング / スプライソソーム / RNAスプライシング / 角化細胞 / 表皮 / 皮膚 / 癌 / 再プログラミング因子 / メラノーマ / 悪性黒色腫 / がん抑制 / 間葉-上皮移行 / がん制御 / IL-17 / Stat3 / IL-22 / IL-23 / Th17 / モデルマウス / 乾癬 / siRNA / calponin homology domain / Calponin homology domain / 細胞間接着 / 上皮細胞 … More Except Principal Investigator トール様受容体 / 乾癬 / Stat3 / Hornerin / Ca / S100 / keratinization / differentiation / skin / 角化 / 分化 / RNA differential display / 皮膚 / 自然免疫 / 皮膚癌 / 皮膚炎症 / モデルマウス / Th17 / 発癌 / 紫外線 / インスリン受容体 / PI3K/Aktシグナル / メタボリック症候群 / 尋常性乾癬 / ２段階発癌モデル / Regnase-1 / 紫外線誘発発癌モデル / 2段階発癌モデル / 細胞内シグナル / 免疫学 / トール様受容体7 / 強皮症 / コラーゲン合成 / ZEB2 / Mowat-Wilson症候群 / 紫外線照射 / 膠原病 / stem cells / growth regulation / 組織構築 / calmin / 骨髄 / Profilaggrin / 増殖 / TGFβ / profilaggrin / hornerin / A11 / S100C / 幹細胞 / 増殖制御 / Ca-binding / actin / filaggrin / gene / TPR / RNA differential diaplay / 海馬 / プルキンエ細胞 / PSD / Ca結合 / アクチン / フィラグリン / 遺伝子 / イミキモド / 紫外線発癌 / 腫瘍免疫 / T細胞 / 再生学 / 付着部炎 / 関節症性乾癬 / IL-23 / バイオロジックス / IL23/Th17 / 表皮角化細胞 Less

皮膚腫瘍における新規スプライソソーム分子Ahedの役割についての研究Principal Investigator
- Principal Investigator
  
  高石樹朗
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kochi University
メタボリック症候群と乾癬発症におけるPI3K/Akt経路の関与の検討
- Principal Investigator
  
  中島喜美子
- Project Period (FY)
  2022 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kochi University
Elucidation of the molecular function of Ahed, a nuclear protein that controls proliferation and differentiation of epidermal keratinocytes.Principal Investigator
- Principal Investigator
  
  Takaishi Mikiro
- Project Period (FY)
  2019 – 2021
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kochi University
Study on the role for epidermal Regnase-1 in regulation of skin inflammation and carcinogenesis.
- Principal Investigator
  
  Sano Shigetoshi
- Project Period (FY)
  2018 – 2020
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Review Section
  
  Basic Section 53050:Dermatology-related
- Research Institution
  Kochi University
Exploration of involvement of TLR7 signaling in development of systemic sclerosis using a mouse model for systemic autoimmune disease
- Principal Investigator
  
  Yamamoto Mayuko
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Studies for tumor suppression induced by over expression of the reprogramming factors.Principal Investigator
- Principal Investigator
  
  TAKAISHI Mikiro
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Participation in collagen synthesis of ZEB2, the causative gene of Mowat-Wilson syndrome.
- Principal Investigator
  
  TERAISHI MIKA
- Project Period (FY)
  2016 – 2018
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
The effect of UV irradiation on development of systemic lupus in mouse model
- Principal Investigator
  
  SANO SHIGETOSHI
- Project Period (FY)
  2015 – 2017
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Induction of mesenchymal to epithelial transition and suppression of cancer invasion by introduction of the reprogramming factorsPrincipal Investigator
- Principal Investigator
  
  TAKAISHI MIKIRO
- Project Period (FY)
  2013 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
自然免疫による抗腫瘍メカニズムの解析:紫外線誘導性皮膚癌モデルマウスを用いた研究
- Principal Investigator
  
  横川真紀
- Project Period (FY)
  2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
紫外線発癌におけるＴ細胞の関与について
- Principal Investigator
  
  喜多川千恵
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Investigation of IL-23/Th17 axis in pathogenesis of psoriasis using a mouse model.Principal Investigator
- Principal Investigator
  
  TAKAISHI Mikiro
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Generation and analysis of model mouse for psoriatic arthritis
- Principal Investigator
  
  YAMAMOTO Mayuko
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Stat3阻害剤による新規乾癬治療法の開発
- Principal Investigator
  
  三好研
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
The role of Th17 in the pathogenesis of psoriasis
- Principal Investigator
  
  NAKAJIMA Kimiko
- Project Period (FY)
  2009 – 2011
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
Constitutive activation of Stat3 reveals a critical role in UVB-induced epithelial carcinogenesis
- Principal Investigator
  
  YOKOGAWA Maki
- Project Period (FY)
  2008 – 2010
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Dermatology
- Research Institution
  Kochi University
上皮細胞間接着における新規分子Calminの機能解析Principal Investigator
- Principal Investigator
  
  高石樹朗
- Project Period (FY)
  2004 – 2005
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Okayama University
Relevance of genes involved in skin tissue formation to human diseases and its application for regenerative medicine.
- Principal Investigator
  
  HUH Nam-ho
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  Okayama University
表皮角化細胞の分化に伴って発現する新規遺伝子4A40の解析Principal Investigator
- Principal Investigator
  
  高石樹朗
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Dermatology
- Research Institution
  Okayama University
表皮角化細胞の分化に伴って発現する新規遺伝子の解析Principal Investigator
- Principal Investigator
  
  高石樹朗
- Project Period (FY)
  1999 – 2000
- Research Category
  
  Grant-in-Aid for Encouragement of Young Scientists (A)
- Research Field
  
  Dermatology
- Research Institution
  Toyama Medical and Pharmaceutical University
Systematic Isolation of Novel Genes Involved in Regulation of Growth and Differentiation of Slain Cells and Their Relevance to Human Diseases.
- Principal Investigator
  
  HUH Nam-ho
- Project Period (FY)
  1999 – 2001
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Dermatology
- Research Institution
  OKAYAMA UNIVERSITY
  Toyama Medical and Pharmaceutical University

[Journal Article] Transdifferentiation of Melanoma Cells by the Reprogramming Factors Attenuates Malignant Nature In?Vitro and In?Vivo2019
- Author(s)
  Takaishi Mikiro、Sano Shigetoshi
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 139 Issue: 1 Pages: 254-257
- DOI
  10.1016/j.jid.2018.06.179
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-16K10161
[Journal Article] Regnase-1, an immuno-modulator, limits the IL-36/IL-36R auto-stimulatory loop in keratinocytes to suppress skin inflammation.2018
- Author(s)
  Takaishi M, Satoh T, Akira S, Sano S
- Journal Title
  
  J Invest Dermatol
  
  Volume: 138 Issue: 6 Pages: 1439-1442
- DOI
  10.1016/j.jid.2017.12.033
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04888
[Journal Article] Critical involvement of ZEB2 in collagen fibrillogenesis: the molecular reminiscent of Mowat-Wilson syndrome with Ehlers-Danlos syndrome.2017
- Author(s)
  Teraishi M, Takaishi M, Nakajima K, Ikeda M, Higashi Y, Shimoda S, Asada Y, Hijikata A, Ohara O, Hirai Y, Mizuno S, Fukada T, Furukawa T, Wakamatsu N, Sano S.
- Journal Title
  
  Scientific Report
  
  Volume: 7:46565 Issue: 1 Pages: 1-10
- DOI
  10.1038/srep46565
- Peer Reviewed / Open Access / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26462225, KAKENHI-PROJECT-26462324, KAKENHI-PROJECT-16K10163, KAKENHI-PROJECT-17K10070, KAKENHI-PROJECT-15H04669, KAKENHI-PROJECT-15K11813
[Journal Article] Mesenchymal to Epithelial Transition Induced by Reprogramming Factors Attenuates the Malignancy of Cancer Cells.2016
- Author(s)
  Takaishi M, Tarutani M, Takeda J, Sano S.
- Journal Title
  
  PLoS One
  
  Volume: 11 Issue: 6 Pages: e0156904-e0156904
- DOI
  10.1371/journal.pone.0156904
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-15H04888
[Journal Article] Psoriatic inflammation facilitates the onset of arthritis in a mouse model.2014
- Author(s)
  Yamamoto M, Nakajima K, Takaishi M, Kitaba S, Magata Y, Kataoka S, Sano S
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 135 Issue: 2 Pages: 445-453
- DOI
  10.1038/jid.2014.426
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-25461700, KAKENHI-PROJECT-25461698
[Journal Article] Cathepsin K Is Involved in Development of Psoriasis-like Skin Lesions through TLR-Dependent Th17 Activation.2013
- Author(s)
  Hirai T, Kanda T, Sato K, Takaishi M, Nakajima K, Yamamoto M, Kamijima R, Digiovanni J, Sano S.
- Journal Title
  
  J Immunol
  
  Volume: 190(9) Issue: 9 Pages: 4805-11
- DOI
  10.4049/jimmunol.1200901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242, KAKENHI-PROJECT-22591243
[Journal Article] Barrier abnormality due to ceramide deficiency leads to psoriasiform inflammation in a mouse model.2013
- Author(s)
  Nakajima K, Terao M, Takaishi M, Kataoka S, Goto-Inoue N, Setou M, Horie K, Sakamoto F, Ito M, Azukizawa H, Kitaba S, Murota H, Itami S, Katayama I, Takeda J, Sano S.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 133 Issue: 11 Pages: 2555-2565
- DOI
  10.1038/jid.2013.199
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242, KAKENHI-PROJECT-24591632, KAKENHI-PROJECT-24591656, KAKENHI-PROJECT-24659529, KAKENHI-PROJECT-24689045
[Journal Article] Cathepsin K is involved in development of psoriasis-like skin lesions through TLR-dependent Th17 activation2013
- Author(s)
  Toshitake Hirai, Takashi Kanda, Kenji Sato, Mikiro Takaishi, Kimiko Nakajima, Mayuko Yamamoto, Reiko Kamijima, John DiGiovanni, Shigetoshi Sano
- Journal Title
  
  J Immunol
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591243
[Journal Article] Attenuation of psoriasis-like skin lesion in a mouse model by topical treatment with indirubin and its derivative E804.2012
- Author(s)
  Miyoshi K, Takaishi M, Digiovanni J, Sano S.
- Journal Title
  
  J Dermatol Sci.
  
  Volume: 65(1) Issue: 1 Pages: 70-2
- DOI
  10.1016/j.jdermsci.2011.10.001
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242
[Journal Article] GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin barrier.2012
- Author(s)
  Tarutani M, Nakajima K, Uchida Y, Takaishi M, Goto-Inoue N, Ikawa M, Setou M, Kinoshita T, Elias PM, Sano S, Maeda Y
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 132(8) Pages: 2019-25
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242
[Journal Article] Imiquimod attenuates the growth of UVB-induced SCC in mice through Th1/Th17 cells.2012
- Author(s)
  Yokogawa M, Takaishi M, Nakajima K, Kamijima R, Digiovanni J, Sano S.
- Journal Title
  
  Mol Carcinog.
  
  Volume: (Epub ahead of print) Issue: 10 Pages: 760-769
- DOI
  10.1002/mc.21901
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242, KAKENHI-PROJECT-24591629
[Journal Article] GPHR-dependent functions of the Golgi apparatus are essential for the formation of lamellar granules and the skin2012
- Author(s)
  Tarutani M, et al.
- Journal Title
  
  J Invest Dermatol
  
  Volume: 132 Issue: 8 Pages: 2019-2025
- DOI
  10.1038/jid.2012.100
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20670006, KAKENHI-PROJECT-22591242, KAKENHI-PROJECT-23370060
[Journal Article] Stat3 as a therapeutic target for the treatment of psoriasis : a clinical feasibility study with STA-21, a Stat3 inhibitor.2011
- Author(s)
  Miyoshi K, Takaishi M, Nakajima K, Ikeda M, Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S.
- Journal Title
  
  J Invest Dermatol.
  
  Volume: 131 Pages: 108-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242
[Journal Article] Stat3 as a Therapeutic Target for the Treatment of Psoriasis :A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor2011
- Author(s)
  三好研、中島喜美子、高石樹朗、佐野栄紀, 他
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: 131 Pages: 108-117
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591244
[Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2011
- Author(s)
  Nakajima K, K. Kanda T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
- Journal Title
  
  J Immnuol
  
  Volume: 186 Pages: 4481-9
- Data Source
  KAKENHI-PROJECT-21591467
[Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model.2011
- Author(s)
  Nakajima K, Kanda T, Takaishi M, Shiga T, Miyoshi K, Nakajima H, Kamijima R, Tarutani M, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S.
- Journal Title
  
  J Immunol.
  
  Volume: 186(7) Issue: 7 Pages: 4481-9
- DOI
  10.4049/jimmunol.1000148
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591242
[Journal Article] Stat3 as a Therapeutic Target for the Treatment of Psoriasis : A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor2011
- Author(s)
  Miyoshi K, Takaishi M, Nakajima K, Ikeda M、Kanda T, Tarutani M, Iiyama T, Asao N, DiGiovanni J, Sano S
- Journal Title
  
  Journal of Investigative Dermatology
  
  Volume: Vol.131 Issue: 1 Pages: 105-117
- DOI
  10.1038/jid.2010.255
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591466, KAKENHI-PROJECT-22591242
[Journal Article] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2011
- Author(s)
  Nakajima K, K.Kand T, Takaishi M, Miyoshi K, Kamijima R, Tarutani M, Benson M, Elloso MM, Iwakura Y, DiGiovanni J, Sano S
- Journal Title
  
  J Immnuol
  
  Volume: 186 Pages: 4481-4489
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-21591467
[Journal Article] Identification of human hornerin and its expression in regenerating and psoriatic skin.2005
- Author(s)
  Takaishi M, Makino T, Morohashi M, Huh NH
- Journal Title
  
  J Biol Chem. 280(6)
  
  Pages: 4696-4703
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370260
[Journal Article] Identification of human hornerin and its expression in regenerating and psoriatic skin.2005
- Author(s)
  Takaishi et al.
- Journal Title
  
  Journal of Biological Chemistry 280(6)
  
  Pages: 1314-1318
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14370260
[Journal Article] Identification of human homerin and its expression in regenerating and psoriatic skin.2005
- Author(s)
  Takaishi et al.
- Journal Title
  
  Journal of Biological Chemistry 280(6)
  
  Pages: 4696-4703
- Data Source
  KAKENHI-PROJECT-14370260
[Journal Article] Expression of hornerin in stratified squamous epithelium in the mouse : a comparative analysis with profilaggrin.2003
- Author(s)
  Makino T, Takaishi M, Toyoda M, Morohashi M, Huh NH
- Journal Title
  
  J Histochem Cytochem. 51(4)
  
  Pages: 485-492
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370260
[Journal Article] S100C/A11 is a key mediator of Ca(2+)-induced growth inhibition of human epidermal keratinocytes.2003
- Author(s)
  Sakaguchi M, Miyazaki M, Takaishi M, Sakaguchi Y, Makino E, Kataoka N, Yamada H, Namba M, Huh NH
- Journal Title
  
  J Cell Biol. 163(4)
  
  Pages: 825-835
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14370260
[Patent] 膠原病の病態モデル動物、当該病態モデル動物の作製方法、及び当該病態モデル動物のスクリーニング方法2012
- Inventor(s)
  佐野栄紀,横川真紀,高石樹朗
- Industrial Property Rights Holder
  国立大学法人高知大学
- Industrial Property Number
  2012-074752
- Filing Date
  2012-03-28
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 腫瘍増殖におけるスプライシング制御分子Ahedの関与2023
- Author(s)
  高石　樹朗、中井　浩三、佐野　栄紀
- Organizer
  第46回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-23K07769
[Presentation] Ahed, a novel spliceosomal protein, is essential for the development and maintenance of the epidermis through regulation of mRNA splicing.2021
- Author(s)
  Mikiro Takaishi, Tatsushi Ishimoto, Masahiro Tokunaga, Chikara Kokubu, Junji Takeda, and Shigetoshi Sano
- Organizer
  The European Society for Dermatological Research, 50th annual meeitng
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] 新規スプライソーソムタンパク質Ahedは表皮の発生とその維持に重要な働きを担う2021
- Author(s)
  高石　樹朗、石元　達士、徳永正浩、國府　力、竹田　潤二、佐野　栄紀
- Organizer
  第44回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] Ahed is a novel component of spliceosome and is required for cell proliferation of epidermal keratinocytes.2020
- Author(s)
  Mikiro Takaishi, Tatsushi Ishimoto, Masahiro Tokunaga, Chikara Kokubu, Junji Takeda, and Shigetoshi Sano
- Organizer
  The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] 皮膚発癌における表皮Regnase-1の寄与2020
- Author(s)
  森坂広行、高石樹朗、審良静男、佐野栄紀
- Organizer
  第27回四国四大学皮膚科講演会（Web開催）
- Data Source
  KAKENHI-PROJECT-18H02833
[Presentation] 表皮角化細胞の増殖におけるAhedの役割2019
- Author(s)
  高石　樹朗、石元　達士、徳永正浩、國府　力、竹田　潤二、佐野　栄紀
- Organizer
  第42回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] Ahed, an uncharacterized nuclear protein, is required for epidermal cell growth and differentiation2019
- Author(s)
  Mikiro Takaishi, Tatsushi Ishimoto, Masahiro Tokunaga, Chikara Kokubu, Junji Takeda, and Shigetoshi Sano
- Organizer
  JAPAN-SINGAPORE INTERNATIONAL SKIN CONFERENCE 2019
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] Ahed plays crucial roles in growth and differentiation of epidermal keratinocytes2019
- Author(s)
  Mikiro Takaishi, Tatsushi Ishimoto, Masahiro Tokunaga, Chikara Kokubu, Junji Takeda, and Shigetoshi Sano
- Organizer
  The 49th ESDR Annual Meeting
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] Ahed is involved in proliferation and differentiation of epidermal keratinocytes2019
- Author(s)
  Mikiro Takaishi, Tatsushi Ishimoto, Masahiro Tokunaga, Chikara Kokubu, Junji Takeda, and Shigetoshi Sano
- Organizer
  The 44th Annual Meeting of the JSID
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-19K08773
[Presentation] Keratinocyte Regnase-1, a down-modulator of skin inflammation,2019
- Author(s)
  Morisaka H, Takaishi M, Akira　S and Sano S
- Organizer
  The44nd Annual Meeting of the Japanese Society for Investigative Dermatology. (JSID)
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-18H02833
[Presentation] 再プログラミング因子による分化転換は悪性黒色腫細胞の悪性度を減少させる。2018
- Author(s)
  高石樹朗、佐野栄紀
- Organizer
  第４１回日本分子生物学会年会
- Data Source
  KAKENHI-PROJECT-16K10161
[Presentation] Forced expression of the reprogramming factors leads to attenuation of melanoma malignancy through MET-like transdifferentiation and suppression of MAPK and AKT pathways2018
- Author(s)
  Mikiro Takaishi and Shigetoshi Sano
- Organizer
  International Investigative Dermatology 2018
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10161
[Presentation] Forced expression of the reprogramming factors attenuated the malignant nature of melanoma cells.2017
- Author(s)
  Mikiro Takaishi, Shigetoshi Sano
- Organizer
  European Society for Dermatological Research
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-16K10161
[Presentation] Regnase-1 in keratinocytes limits the IL-36/IL-36R auto-stimulatory loop to buffer skin inflammation.2017
- Author(s)
  Sano S, Ohko K,　Satoh　T, Akira　S, Takaishi　M.
- Organizer
  The42nd Annual Meeting of the Japanese Society for Investigative Dermatology
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04888
[Presentation] Mowat-Wilson症候群は変異ZEB2によるコラーゲン合成異常を介して Ehlers-Danlos様症状を呈する2016
- Author(s)
  寺石美香、高石樹朗、中島喜美子、佐野栄紀
- Organizer
  第48回日本結合組織学会学術大会
- Place of Presentation
  長崎大学医学部良順会館・記念講堂（長崎県長崎市）
- Year and Date
  2016-06-24
- Data Source
  KAKENHI-PROJECT-16K10163
[Presentation] A novel gene Ahed plays key roles in proliferation, survival, and differentiation of murine epidermis.2016
- Author(s)
  M Takaishi, M Tokunaga, C Kokubu, J Takeda, and S Sano
- Organizer
  46th Annual ESDR Meeting 2016
- Place of Presentation
  Technical University of Munich(Munich, Germany)
- Year and Date
  2016-09-07
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-15H04888
[Presentation] Attenuation of human SCC malignancy by introduction of reprogramming factors2015
- Author(s)
  Mikiro Takaishi, Masahito Tarutani, Junji Takeda and Shigetoshi Sano
- Organizer
  第29回表皮細胞研究会
- Place of Presentation
  佐賀県、佐賀市、ホテルニューオータニ佐賀
- Year and Date
  2015-11-14
- Data Source
  KAKENHI-PROJECT-25461698
[Presentation] Attenuation of human SCC malignancy by introduction of reprogramming factors2015
- Author(s)
  Mikiro Takaishi, Masahito Tarutani, Junji Takeda and Shigetoshi Sano
- Organizer
  The European Society for Dermatological Research
- Place of Presentation
  Postillion Convention Centre-WTC, Rotterdam, The Netherlands
- Year and Date
  2015-09-09
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461698
[Presentation] Introduction of the reprogramming factors into B16 murine melanoma cells attenuated in vivo metastasis through promoting mesencymal-epithelial transition2013
- Author(s)
  Takaishi M, Tarutani M, Takeda J, Sano S
- Organizer
  International Investigative Dermatology
- Place of Presentation
  Edinburgh, Scotland, UK
- Data Source
  KAKENHI-PROJECT-25461698
[Presentation] Involvement of TNF-α converting enzyme in the development of psoriasis-like lesions in K5.Stat3C transgenic mice2012
- Author(s)
  Sato K, Takaishi M, Tokuoka S, Sano S
- Organizer
  The 42nd Annual ESDR Meeting
- Place of Presentation
  Palazzo del Casino, Venice Lido Congress Centre (Italy)
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent signaling2011
- Author(s)
  Takaishi, M.
- Organizer
  The 37th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  京都国際会館
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Development of psoriasis-like lesions in a mouse model by IL-23-dependent but IL-22-independent.2011
- Author(s)
  Takaishi M, Nakajima K, Ouyang W, Sano S.
- Organizer
  The 36th Annual Meeting of the Japanese Society for Investigative Dermatology
- Place of Presentation
  京都国立国際会館(京都市)
- Year and Date
  2011-12-09
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 乾癬マウスモデルにおけるIL-23依存性IL-22非依存性シグナルによる皮疹形成2011
- Author(s)
  高石樹朗, 中島喜美子, Wenjun Ouyang, 佐野栄紀.
- Organizer
  第26回日本乾癬学会学術大会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 乾癬マウスモデルにおけるIL-23依存性IL-22非依存性シグナルによる皮疹形成2011
- Author(s)
  高石樹朗
- Organizer
  第26回日本乾癬学会学術大会
- Place of Presentation
  大阪国際会議場
- Year and Date
  2011-09-10
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] IL-23 is essential, but IL-22 is dispensable for the development of psoriasis-like lesions in K5.2011
- Author(s)
  Takaishi M, Nakajima K, Ouyang W, Sano S.
- Organizer
  Stat3C mice 41st Annual ESDR Meeting
- Place of Presentation
  Barcelona, Spain
- Year and Date
  2011-09-09
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] IL-23 is essential, but IL-22 is dispensable for the development of psoriasis-like lesions in K5.Stat3C mice2011
- Author(s)
  Takaishi, M.
- Organizer
  European Society for Dermatological Research, 41st Annual Meeting
- Place of Presentation
  Barcelona International Convension Center (Spain)
- Year and Date
  2011-09-07
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model.2010
- Author(s)
  Nakajima K, Kanda T, Takaishi M, Miyoshi K, Benson JM, Elloso MM, Iwakura Y, DiGiovanni J, Sano S.
- Organizer
  SID 2010 Annual Meeting
- Place of Presentation
  Hilton Atlanta Hotel Atlanta, GA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] The possible contribution of IL-22-producing-non-T cells in the development of psoriasis-like lesions in the mouse model2010
- Author(s)
  Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
- Organizer
  第35回日本研究皮膚科学会
- Place of Presentation
  和歌山
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] Stat3をターゲットとした新規乾癬治療法の開発2010
- Author(s)
  三好研、中島喜美子、高石樹朗、佐野栄紀
- Organizer
  第109回日本皮膚科学会総会
- Place of Presentation
  大阪国際会議場(大阪市)
- Year and Date
  2010-04-17
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model : anti-IL-6R antibody had no inhibitory effect for the development of lesion2010
- Author(s)
  Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
- Organizer
  The 14^<th> international congress of immunology
- Place of Presentation
  Kobe, Japan
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] Role of Smad-interacting protein 1 (SIP1) in collagen synthesis of dermal fibroblasts.2010
- Author(s)
  Teraishi M, Takaishi M, Ikeda M, Furukwa T, Shimoda S, Asada Y, Sano S.
- Organizer
  SID 2010 Annual Meeting
- Place of Presentation
  Hilton Atlanta Hotel Atlanta, GA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Stat3阻害剤であるSTA-21はヒト正常表皮角化細胞とヒト角化細胞由来株細胞の分化を誘導する2010
- Author(s)
  高石樹朗、横川真紀、三好研、中島喜美子、John DiGiovanni、佐野栄紀
- Organizer
  日本組織培養学会第83回大会
- Place of Presentation
  岡山大学(岡山市)
- Year and Date
  2010-05-21
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] STA-21, a stat3 inhibitor, induces differentiation of normal human epidermal keratinocytes and human, keratinocyte derived cell lines.2010
- Author(s)
  Takaishi M, Yokogawa M, Miyoshi K, Nakajima K, DiGiovanni J, Sano S.
- Organizer
  70th SID 2010 Annual Meeting
- Place of Presentation
  Hilton Atlanta Hotel, Atlanta, U.S.A
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Stat3 as a therapeutic target for the treatment of psoriasis2010
- Author(s)
  三好研、中島喜美子、高石樹朗、佐野栄紀
- Organizer
  第109回日本皮膚科学会総会
- Place of Presentation
  大阪国際会議場(大阪)
- Year and Date
  2010-04-16
- Data Source
  KAKENHI-PROJECT-22591244
[Presentation] STA-21, a stat3 inhibitor, induces differentiation of normal human epidermal keratinocytes and human keratinocyte derived cell lines.2010
- Author(s)
  Takaishi M, Yokogawa M, Miyoshi K, Nakajima K, DiGiovanni J, Sano S.
- Organizer
  SID 2010 Annual Meeting
- Place of Presentation
  Hilton Atlanta Hotel Atlanta, GA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 乾癬におけるindirubinの有効性2010
- Author(s)
  三好研、高石樹朗、佐野栄紀
- Organizer
  第25回日本乾癬学会学術大会
- Place of Presentation
  宇部全日空ホテル(宇部市)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2010
- Author(s)
  Nakajima K, Kanda T, Takaishi M, Miyoshi M, Benson JM, Elloso MM, Iwakura Y, DiGivanni J, Sano S
- Organizer
  The 70^<th> SID annual meeting
- Place of Presentation
  Atlanta, USA
- Year and Date
  2010-05-05
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] Possible contribution of IL-22-producing non-T cells to the development of psoriasis-like lesion in a mouse model.2010
- Author(s)
  Nakajima K, Singa S, Kanda T, Takaishi M, Miyoshi K, Sano S.
- Organizer
  日本研究皮膚科学会第35回年次学術大会
- Place of Presentation
  和歌山県立文化会館(和歌山市)
- Year and Date
  2010-12-04
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 皮膚線維芽細胞のコラーゲン合成におけるSmad interacting protein 1(SIP1)の働き2010
- Author(s)
  寺石美香、高石樹朗、池田光徳、古川貴久、深田俊幸、下田信治、朝田芳信、佐野栄紀
- Organizer
  第17回分子皮膚科学フォーラム
- Place of Presentation
  ホテルオークラ福岡(福岡市)
- Year and Date
  2010-07-09
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 日光角化症におけるイミキモドの抗腫瘍作用:モデルマウスを用いた解析2010
- Author(s)
  横川真紀、志賀建夫、高石樹朗、樽谷勝仁、佐野栄紀
- Organizer
  第6回加齢皮膚医学研究会・第358回日本皮膚科学会新潟地方会
- Place of Presentation
  新潟大学有壬記念館(新潟市)
- Year and Date
  2010-07-03
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] The crosstalk between IL-17, IL-22 and keratinocytes in development of psoriasis-like lesions in a mouse model2010
- Author(s)
  Nakajima K, Tateo Shiga, Mikiro Takaishi, Ken Miyoshi, Shigetoshi Sano
- Organizer
  第24回表皮細胞研究会
- Place of Presentation
  高知
- Year and Date
  2010-10-09
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] 表皮特異的Golgi pH regulator欠損マウスのphenotype2010
- Author(s)
  樽谷勝仁、中島喜美子、高石樹朗、佐野栄紀、前田裕輔、木下タロウ
- Organizer
  第25回角化症研究会
- Place of Presentation
  東京商工会議所(東京都)
- Year and Date
  2010-07-31
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesion in a mouse model2010
- Author(s)
  Nakajima K. Kanda T, Takaishi M, Miyoshi K, Benson JM, Elloso MM, Gutshall LL, Naso MF, Iwakura Y, DiGiovanni J, Sano S.
- Organizer
  14th International congress of immunology
- Place of Presentation
  神戸ポートピアホテル(神戸市)
- Year and Date
  2010-08-28
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] K5.Stat3トランスジェニックマウスに生じる乾癬様皮疹におけるPlasmacytoid dendritic cells(PDCs)の関与2010
- Author(s)
  高石樹朗, 片岡健, Kaoru Kiguchi, Michal Gilliet、佐野栄紀、John Digiovanni.
- Organizer
  第25回日本乾癬学会学術大会
- Place of Presentation
  宇部全日空ホテル(宇部市)
- Year and Date
  2010-09-03
- Data Source
  KAKENHI-PROJECT-22591242
[Presentation] 乾癬モデルマウスにおけるTh17の関与について2009
- Author(s)
  中島喜美子, 高石樹朗, 三好研, 佐野栄紀
- Organizer
  第24回日本乾癬学会学術大会
- Place of Presentation
  東海大校友会館(東京)
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] Development of psoriasis is dependent on IL-12/ 23p40, but partially on IL-17A in a mouse model2009
- Author(s)
  Takaishi M, Nakajima K, DiGiovanni J, Iwakura Y, Sano S
- Organizer
  The 3^<9th> ESDR annual meeting
- Place of Presentation
  Budapest, Hungary
- Year and Date
  2009-09-09
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] 乾癬モデルマウスにおけるTh17の関与について2009
- Author(s)
  中島喜美子,高石樹朗,三好研,佐野栄紀
- Organizer
  第24回日本乾癬学会
- Place of Presentation
  東京
- Year and Date
  2009-09-04
- Data Source
  KAKENHI-PROJECT-21591467
[Presentation] Epigenetic regulation of E-cadherin in the reprogramming gene-introduced cancer cells.
- Author(s)
  Mikiro Takaishi, Masahito Tarutani, Junji Takeda and Shigetoshi Sano.
- Organizer
  The 39th Annual Meeting of the Japanese Society for Investigative Dermatology.
- Place of Presentation
  Hotel Hankyu Expopark, Suita, Osaka, Japan
- Year and Date
  2014-12-12 – 2014-12-14
- Data Source
  KAKENHI-PROJECT-25461698

1. SANO Shigetoshi (80273621)

# of Collaborated Projects: 16 results

# of Collaborated Products: 61 results
2. NAKAJIMA Kimiko (20403892)

# of Collaborated Projects: 8 results

# of Collaborated Products: 31 results
3. MIYOSHI Ken (20274392)

# of Collaborated Projects: 4 results

# of Collaborated Products: 21 results
4. TERAISHI Mika (40437736)

# of Collaborated Projects: 4 results

# of Collaborated Products: 1 results
5. YAMAMOTO Mayuko (20423478)

# of Collaborated Projects: 4 results

# of Collaborated Products: 2 results
6. YOKOGAWA Maki (40346721)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
7. 石元達士 (40750039)

# of Collaborated Projects: 3 results

# of Collaborated Products: 0 results
8. MASAHIRO Miyazaki (90116509)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
9. SHIGA Takeo (70444768)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
10. MAKAJIMA Hideki (70314995)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
11. HUH Nam-ho (70173573)

# of Collaborated Projects: 2 results

# of Collaborated Products: 3 results
12. MOROHASHI Masaaki (50018719)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
13. 大湖健太郎 (90595274)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
14. IKEDA Mitsunori (70212785)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
15. KATAOKA Ken (10293317)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
16. SAKAGUCHI Masakiyo (70379840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
17. MIYAKE Kensuke (60229812)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
18. 喜多川千恵 (60527589)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
19. 樽谷勝仁 (30301261)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
20. 高田智也 (10403891)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
21. 森坂広行 (60826840)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
22. 岡田随象 (70727411)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
23. MAGATA Yasuhiro

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
24. 若松延昭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Takaishi Mikiro 高石 樹朗

TAKAISHI Mikiro 高石 樹朗

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皮膚腫瘍における新規スプライソソーム分子Ahedの役割についての研究Principal Investigator

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Elucidation of the molecular function of Ahed, a nuclear protein that controls proliferation and differentiation of epidermal keratinocytes.Principal Investigator

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Studies for tumor suppression induced by over expression of the reprogramming factors.Principal Investigator

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Induction of mesenchymal to epithelial transition and suppression of cancer invasion by introduction of the reprogramming factorsPrincipal Investigator

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Investigation of IL-23/Th17 axis in pathogenesis of psoriasis using a mouse model.Principal Investigator

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Takaishi Mikiro 高石樹朗

TAKAISHI Mikiro 高石樹朗