nagane yuriko 長根百合子

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NAGANE Yuriko 長根百合子

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Researcher Number	10306003
Other IDs
Affiliation (Current)	2025: 公益財団法人総合花巻病院(臨床研究部), 脳神経内科, 脳神経内科部長
Affiliation (based on the past Project Information) *help	2006: 岩手医大, 医学部, 助手 2005: 岩手医科大学, 医学部・専門医員 1998 – 2004: 岩手医科大学, 医学部, 助手
Review Section/Research Field	Principal Investigator Neurology Except Principal Investigator Neurology
Keywords	Principal Investigator thymus / CD44 / dendritic Cell / Toll like receptor / myasthenia gravis / FK506 / IL-2産生能 / 重症筋無力症 Except Principal Investigator α7nAChR / PC12 … More / aging / neurite outgrowth / cell cycle / tau / Hypoxia / Cell cycle / ERK / human brain / extracellular-signal-regulated kinase / cDNA array / 老化 / ニューロン / APP / RAGE / transcription / promoter / methylcytosines / Protein kinase Cδ / Neurite outgrowth / Extracellular-signal-regulated kinase / Angiotensin II / Neuronal damage / DNA fragmentation / Akt / cyclin-dependent kinase 5 / p35 / extracellular-signal-regulated kianse / α7サブタイプ / ニコチン性アセチルコリン受容体 / Cell death / proten kinase C δ / candesartan / AT2 / AT1 / protein kinase Cδ / hypoxia / angiotensin II / リン酸化 / アセチルコリン受容体 / DNAアレイ / α7nAchR / 転写調節領域 / タウ蛋白 / アミロイド前駆体蛋白 / bisulfite法 / 加齢 / プロモーター領域 / メチルシトシン / 補体 / α7サブユニット / ニコチン性Ach受容体 Less

重症筋無力症における胸腺内病態とTolllike receptor発現様式の関連Principal Investigator
- Principal Investigator
  
  長根百合子
- Project Period (FY)
  2005 – 2006
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Iwate Medical University
末梢血単核球IL-2産生能高値の重症筋無力症例の病態と免疫抑制剤FK506の効果Principal Investigator
- Principal Investigator
  
  長根百合子
- Project Period (FY)
  2003 – 2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Neurology
- Research Institution
  Iwate Medical University
Effects of nicotinic acetylcholine receptor overexpression in neuronal cells.
- Principal Investigator
  
  UTSUGISAWA Kimiaki
- Project Period (FY)
  2002 – 2004
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Neurology
- Research Institution
  Iwate Medical University
Gene expression profile of aging human brain and its in vitro model
- Principal Investigator
  
  TOHGI Hideo
- Project Period (FY)
  2001 – 2002
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Neurology
- Research Institution
  Iwate Medical University
Changes with age in DNA methylation and transcription in human cerebral cortex.
- Principal Investigator
  
  TOHGI Hideo
- Project Period (FY)
  1998 – 2000
- Research Category
  
  Grant-in-Aid for Scientific Research (B).
- Research Field
  
  Neurology
- Research Institution
  Iwate Medical University

All 2005 2004 2003 2002

All Journal Article

[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis -A randomized pilot study-2005
- Author(s)
  Nagane Y, Utsugisawa K, et al.
- Journal Title
  
  Eur Neurol (in press)
- Data Source
  KAKENHI-PROJECT-15790454
[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis -A randomized pilot study-2005
- Author(s)
  Y.Nagane, K.Utsugisawa, D.Obara, R.Kondoh, Y.Terayama
- Journal Title
  
  Eur Neurol (in press)
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Candesartan prevents angiotensin II -induced facilitation of hypoxic neuronal damage through PKC δ inhibition.2005
- Author(s)
  K.Utsugisawa, Y.Nagane, T.Utsugisawa, D.Obara, Y.Terayama
- Journal Title
  
  Mol Brain Res in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Perivascular infiltrate of memory lymphocytes and mature dendritic cells in MG thymoma2005
- Author(s)
  Nagane Y, Utsugisawa K et al.
- Journal Title
  
  Neurology 65
  
  Pages: 770-772
- Data Source
  KAKENHI-PROJECT-17790588
[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis-A randomized pilot study-2005
- Author(s)
  Y.Nagane, K.Utsugisawa, D.Obara, R.Kondoh, Y.Terayama
- Journal Title
  
  Eur Neurol in press
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKC δ inhibition.2005
- Author(s)
  K.Utsugisawa, Y.Nagane, T.Utsugisawa, D.Obara, Y.Terayama.
- Journal Title
  
  Mol Brain Res (in press)
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Efficacy of low dose FK506 in the treatment of myasthenia gravis - A randomized pilot study2005
- Author(s)
  Nagane Y, Utsugisawa K et al.
- Journal Title
  
  Eur Neurol 53
  
  Pages: 146-150
- Data Source
  KAKENHI-PROJECT-17790588
[Journal Article] Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKCδinhibition.2004
- Author(s)
  K.Utsugisawa, Y.Nagane, T.Utsugisawa, D.Obara, Y.Terayama.
- Journal Title
  
  Mol Brain Res (in press)
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Clinical characteristics and efficacy of FK506 in myasthenia gravis patients with high Interleukin-2 productivity in peripheral blood mononuclear cells.2004
- Author(s)
  K.Utsugisawa, Y.Nagane, Y.Terayama.
- Journal Title
  
  Neurology 62
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Effects of FK506 on myasthenia gravis patients with high interleukin-2 productivity in peripheral blood mononuclear cells.2003
- Author(s)
  Utsugisawa K, Nagane Y, Yonezawa H, Obara D, Kondoh R, Tohgi H
- Journal Title
  
  Muscle Nerve 27
  
  Pages: 245-248
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Interleukin-2 production by peripheral blood mononuclear cells from patients with myasthenia gravis.2003
- Author(s)
  Utsugisawa K, Nagane Y et al.
- Journal Title
  
  Eur Neurol 49・3
  
  Pages: 160-163
- Data Source
  KAKENHI-PROJECT-15790454
[Journal Article] Effects of FK506 on myasthenia gravis with high interleukin-2 productivity in peripheral blood mononuclear cells.2003
- Author(s)
  Utsugisawa K, Nagane Y et al.
- Journal Title
  
  Muscle Nerve 27・2
  
  Pages: 245-248
- Data Source
  KAKENHI-PROJECT-15790454
[Journal Article] Interleukin-2 production by peripheral blood mononuclear cells from patients with myasthenia gravis.2003
- Author(s)
  Utsugisawa K, Nagane Y, Obara D, Kondoh R, Yonezawa H, Tohgi H
- Journal Title
  
  Fur Neurol 49
  
  Pages: 160-163
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Dendritic cells in hyperplastic thymuses from patents with myasthenia gravis.2003
- Author(s)
  Nagane Y, Utsugisawa K, et al.
- Journal Title
  
  Muscle Nerve 27・5
  
  Pages: 582-589
- Data Source
  KAKENHI-PROJECT-15790454
[Journal Article] Dendritic cells in hyperplastic thymuses from patients with myasthenia gravis.2003
- Author(s)
  Nagane Y, Utsugisawa K, Obara D, Yamagata M, Tohgi H
- Journal Title
  
  Muscle Nerve 27
  
  Pages: 582-589
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Hypoxic condition interferes with phosphorylation of Akt atThr308 in cultured rat PC12 cells.2002
- Author(s)
  Obara D, Utsugisawa K, Nagane Y, Tohgi H
- Journal Title
  
  Neurosci Lett 332
  
  Pages: 167-170
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Over-expression of α7 nicotinic acetyicholine receptor induces sustained ERK phosphorylation and N-cadherin expression in PC12 cells.2002
- Author(s)
  Utsugisawa K, Nagane Y, Obara D, Toligi H
- Journal Title
  
  Mol Brain Res 106
  
  Pages: 88-93
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] The Effect of Combined Therapy with Immunoadsorption andHigh-Dose Intravenous Methyiprednisolone on Myasthenia Gravis.2002
- Author(s)
  Munakata R, Utsugisawa K, Nagane Y, Yamagata M, Oikawa M, Obara D, Tohgi H
- Journal Title
  
  Eur Neurol 48
  
  Pages: 115-117
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Over-expression of α7 nicotinic acetyicholine receptor preventsGi-arrest and DNA fragmentation in PC12 cells after hypoxia.2002
- Author(s)
  Utsugisawa K, Nagane Y, Obara D, Tohgi H
- Journal Title
  
  J Neurochem 81
  
  Pages: 497-505
- Description
  「研究成果報告書概要(欧文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Over-expression of α7 nicotinic acetylcholine receptor induces sustained ERK phosphorylation and N-cadherin expression in PC12 cells.2002
- Author(s)
  Utsugisawa K, Nagane Y, Obara D, Tohgi H
- Journal Title
  
  Mol Brain Res 106
  
  Pages: 88-93
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Over-expression of α7 nicotinic acetylcholine receptor prevents G1-arrest and DNA fragmentation in PC12 cells after hypoxia.2002
- Author(s)
  Utsugisawa K, Nagane Y, Obara D, Tohgi H
- Journal Title
  
  J Neurochem 81
  
  Pages: 497-505
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570614
[Journal Article] Hypoxic condition interferes with phosphorylation of Akt at Thr^<308> in cultured rat PC12 cells.2002
- Author(s)
  Obara D, Utsugisawa K, Nagane Y, Tohgi H
- Journal Title
  
  Neurosci Lett 332
  
  Pages: 167-170
- Description
  「研究成果報告書概要(和文)」より
- Data Source
  KAKENHI-PROJECT-14570614

1. UTSUGISAWA Kimiaki (00244913)

# of Collaborated Projects: 3 results

# of Collaborated Products: 16 results
2. ABE Takashi (30202667)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
3. TOHGI Hideo (90155490)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
4. TAKAHASHI Satoshi (50216719)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
5. YAMAGATA Munehisa (00295974)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results

nagane yuriko 長根 百合子

NAGANE Yuriko 長根 百合子

Research Projects

Research Products

Co-Researchers

重症筋無力症における胸腺内病態とTolllike receptor発現様式の関連Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

末梢血単核球IL-2産生能高値の重症筋無力症例の病態と免疫抑制剤FK506の効果Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Effects of nicotinic acetylcholine receptor overexpression in neuronal cells.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Gene expression profile of aging human brain and its in vitro model

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Changes with age in DNA methylation and transcription in human cerebral cortex.

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis -A randomized pilot study-2005

Author(s)

Journal Title

Data Source

[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis -A randomized pilot study-2005

Author(s)

Journal Title

Data Source

[Journal Article] Candesartan prevents angiotensin II -induced facilitation of hypoxic neuronal damage through PKC δ inhibition.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Perivascular infiltrate of memory lymphocytes and mature dendritic cells in MG thymoma2005

Author(s)

Journal Title

Data Source

[Journal Article] Efficacy of low-dose FK506 in the treatment of myasthenia gravis-A randomized pilot study-2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKC δ inhibition.2005

Author(s)

Journal Title

Description

Data Source

[Journal Article] Efficacy of low dose FK506 in the treatment of myasthenia gravis - A randomized pilot study2005

Author(s)

Journal Title

Data Source

[Journal Article] Candesartan prevents angiotensin II-induced facilitation of hypoxic neuronal damage through PKCδinhibition.2004

Author(s)

Journal Title

Data Source

[Journal Article] Clinical characteristics and efficacy of FK506 in myasthenia gravis patients with high Interleukin-2 productivity in peripheral blood mononuclear cells.2004

Author(s)

Journal Title

Data Source

[Journal Article] Effects of FK506 on myasthenia gravis patients with high interleukin-2 productivity in peripheral blood mononuclear cells.2003

Author(s)

Journal Title

Description

Data Source

[Journal Article] Interleukin-2 production by peripheral blood mononuclear cells from patients with myasthenia gravis.2003

nagane yuriko 長根百合子

NAGANE Yuriko 長根百合子