Sekine Shigeki 関根茂樹

… Alternative Names

SEKINE Shigeki 関根茂樹

関根茂樹セキネシゲキ

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Researcher Number	10321879
Other IDs
Affiliation (Current)	2025: 慶應義塾大学, 医学部(信濃町), 教授
Affiliation (based on the past Project Information) *help	2015 – 2022: 国立研究開発法人国立がん研究センター, 中央病院, 医長 2015: 国立研究開発法人国立がん研究センター, その他部局等, 研究員 2015: 国立研究開発法人国立がん研究センター, 中央病院病理科, 医長 2014: 独立行政法人国立がん研究センター, その他部局等, 医長 2013 – 2014: 独立行政法人国立がん研究センター, 中央病院, 医長 … More 2011 – 2012: 独立行政法人国立がん研究センター, 研究所, ユニット長 2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所病理部, 室長 2009: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 研究所病理部, 室長 2008: National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East, 病理部, 室長 2004: 国立がんセンター, 研究員 2003: 国立がんセンター研究所, 病理部, 研究員 2002: 国立がんセンター, 研究所・病理部, 研究員 Less
Review Section/Research Field	Principal Investigator Human pathology / Experimental pathology / Basic Section 49020:Human pathology-related / Human pathology Except Principal Investigator Pathological medical chemistry / Surgical dentistry
Keywords	Principal Investigator 大腸癌 / β-catenin / 発癌過程 / 腺癌 / 腺腫 / 十二指腸 / 大腸ポリープ / 鋸歯状病変 / WNT / 十二指腸癌 … More / 幽門腺腺腫 / 胃上皮化生 / 鋸歯状腺腫 / 消化管腫瘍 / GNAS / 肝細胞がん / miRNA / Dicer / 肝発がん / 肝がん / 肝 / E-cadherin / LEF1 / TCF / 相同組み換え … More Except Principal Investigator 遺伝子欠損マウスモデル / 副作用発現予測 / 分子標的治療薬 / 遺伝子欠損マウス / 抗体スクリーニング / リン酸化タンパク質発現プロファイル / 逆相タンパク質マイクロアレイ / 舌扁平上皮がん / キノームプロファイル / 抗体ライブラリー / 組織マイクロアレイ / 舌がん / 口腔扁平上皮がん / 抗体基盤プロテオミクス / 分子標的治療 / 口腔がん / キノーム Less

Molecular analysis of duodenal carcinogenesisPrincipal Investigator
- Principal Investigator
  
  Shigeki Sekine
- Project Period (FY)
  2020 – 2022
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 49020:Human pathology-related
- Research Institution
  National Cancer Center Japan
WNT pathway-related genetic alterations in colorectal tumorsPrincipal Investigator
- Principal Investigator
  
  Sekine Shigeki
- Project Period (FY)
  2017 – 2019
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Japan
GNAS mutations in gastrointestinal tumorsPrincipal Investigator
- Principal Investigator
  
  Sekine Shigeki
- Project Period (FY)
  2014 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Japan
Development of novel molecular targets for oral cancer with kinome profile by antibody-based proteomics
- Principal Investigator
  
  Kazufumi Honda
- Project Period (FY)
  2011 – 2015
- Research Category
  
  Grant-in-Aid for Scientific Research (B)
- Research Field
  
  Surgical dentistry
- Research Institution
  National Cancer Center Japan
ＴＮＩＫ遺伝子欠損マウス開発による大腸発がん制御機構解明と標的薬の副作用発現予測
- Principal Investigator
  
  下重美紀
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Pathological medical chemistry
- Research Institution
  Nagasaki University
  National Cancer Center Japan
Analysis of tumor suppressive effects of miRNA using Dicer-deficient micePrincipal Investigator
- Principal Investigator
  
  SEKINE Shigeki
- Project Period (FY)
  2011 – 2013
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Experimental pathology
- Research Institution
  National Center of Neurology and Psychiatry
Role of β-catenin in the liver and liver cancerPrincipal Investigator
- Principal Investigator
  
  SEKINE Shigeki
- Project Period (FY)
  2008 – 2009
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Experimental pathology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
胃癌における既知癌遺伝子・癌抑制遺伝子変異および病理組織像の総合的解析Principal Investigator
- Principal Investigator
  
  関根茂樹
- Project Period (FY)
  2004
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East
相同組み換えを用いた変異β-catenin・p53のヒト腫瘍における機能解析Principal Investigator
- Principal Investigator
  
  関根茂樹
- Project Period (FY)
  2002 – 2003
- Research Category
  
  Grant-in-Aid for Young Scientists (B)
- Research Field
  
  Human pathology
- Research Institution
  National Cancer Center Research Institute and Research Center for Innovative Oncology, National Cancer Center Hospital East

All 2021 2020 2018 2017 2016 2015 2014 2013 2012 2011 2009 Other

All Journal Article Other

[Journal Article] APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum2021
- Author(s)
  Ishizu Kenichi、Hashimoto Taiki、Naka Tomoaki、Yatabe Yasushi、Kojima Motohiro、Kuwata Takeshi、Nonaka Satoru、Oda Ichiro、Esaki Minoru、Kudo Masashi、Gotohda Naoto、Yoshida Teruhiko、Yoshikawa Takaki、Sekine Shigeki
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 56 Issue: 11 Pages: 988-998
- DOI
  10.1007/s00535-021-01823-x
- Peer Reviewed / Open Access
- Data Source
  KAKENHI-PROJECT-20H03461, KAKENHI-PROJECT-20K07401
[Journal Article] Clinicopathological and molecular correlations in traditional serrated adenoma2020
- Author(s)
  Sekine Shigeki、Yamashita Satoshi、Yamada Masayoshi、Hashimoto Taiki、Ogawa Reiko、Yoshida Hiroshi、Taniguchi Hirokazu、Kojima Motohiro、Ushijima Toshikazu、Saito Yutaka
- Journal Title
  
  Journal of Gastroenterology
  
  Volume: 55 Issue: 4 Pages: 418-427
- DOI
  10.1007/s00535-020-01673-z
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-18K07925, KAKENHI-PROJECT-17K08711, KAKENHI-PROJECT-18K07035
[Journal Article] Clinicopathologic and Molecular Characteristics of Familial Adenomatous Polyposis?associated Traditional Serrated Adenoma2020
- Author(s)
  Okamura Takuma、Hashimoto Taiki、Naka Tomoaki、Yoshida Teruhiko、Tanabe Noriko、Ogawa Reiko、Yamada Masayoshi、Saito Yutaka、Yatabe Yasushi、Sekine Shigeki
- Journal Title
  
  American Journal of Surgical Pathology
  
  Volume: Publish Ahead of Print Issue: 9 Pages: 1282-1289
- DOI
  10.1097/pas.0000000000001502
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711, KAKENHI-PROJECT-20H03461
[Journal Article] Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp2018
- Author(s)
  Cho H, Hashimoto T, Yoshida H, Taniguchi H, Ogawa R, Mori T, Hiraoka N, Saito Y, Sekine S
- Journal Title
  
  Histopathology
  
  Volume: 73 Issue: 4 Pages: 672-80
- DOI
  10.1111/his.13688
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711
[Journal Article] Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion2018
- Author(s)
  Hashimoto T, Tanaka Y, Ogawa R, Mori T, Yoshida H, Taniguchi H, Hiraoka N, Kojima M, Oono Y, Saito Y, Sekine S
- Journal Title
  
  Mod Pathol
  
  Volume: 31 Issue: 10 Pages: 1588-98
- DOI
  10.1038/s41379-018-0069-8
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711, KAKENHI-PROJECT-18K07035
[Journal Article] Adenocarcinoma of the colon presenting as a submucosal tumor2017
- Author(s)
  Cho Hourin、Sekine Shigeki、Sekiguchi Masau
- Journal Title
  
  Digestive Endoscopy
  
  Volume: 30 Issue: 1 Pages: 114-115
- DOI
  10.1111/den.12949
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711
[Journal Article] Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum2017
- Author(s)
  Kojima Motohiro、Shimazaki Hideyuki、Iwaya Keiichi、Nakamura Takahiro、Kawachi Hiroshi、Ichikawa Kazuhito、Sekine Shigeki、Ishiguro Shingo、Shimoda Tadakazu、Kushima Ryoji、Yao Takashi、Fujimori Takahiro、Hase Kazuo、Watanabe Toshiaki、Sugihara Kenichi、Lauwers Gregory Y.、Ochiai Atsushi
- Journal Title
  
  Human Pathology
  
  Volume: 66 Pages: 230-237
- DOI
  10.1016/j.humpath.2017.04.031
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711
[Journal Article] Cytoplasmic MSH2 immunoreactivity in a patient with Lynch syndrome with an EPCAM-MSH2 fusion.2017
- Author(s)
  Sekine S, Ogawa R, Saito S, Ushiama M, Shida D, Nakajima T, Taniguchi H, Hiraoka N, Yoshida T, Sugano K.
- Journal Title
  
  Histopathology
  
  Volume: 49 Issue: 4 Pages: 664-669
- DOI
  10.1111/his.13104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460429
[Journal Article] Mismatch repair deficiency commonly precedes adenoma formation in Lynch syndrome-associated colorectal tumorigenesis2017
- Author(s)
  Sekine S, Mori T, Ogawa R, Tanaka M, Yoshida H, Taniguchi H, Nakajima T, Sugano K, Yoshida T, Kato M, Furukawa E, Ochiai A, Hiraoka N
- Journal Title
  
  Mod Pathol
  
  Volume: 印刷中 Issue: 8 Pages: 1144-1151
- DOI
  10.1038/modpathol.2017.39
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460429
[Journal Article] WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps2017
- Author(s)
  Hashimoto Taiki、Yamashita Satoshi、Yoshida Hiroshi、Taniguchi Hirokazu、Ushijima Toshikazu、Yamada Tesshi、Saito Yutaka、Ochiai Atsushi、Sekine Shigeki、Hiraoka Nobuyoshi
- Journal Title
  
  The American Journal of Surgical Pathology
  
  Volume: 41 Issue: 9 Pages: 1188-1197
- DOI
  10.1097/pas.0000000000000877
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-17K08711, KAKENHI-PROJECT-16K19097
[Journal Article] SMYD2 overexpression is associated with tumor cell proliferation and a worse outcome in human papillomavirus-unrelated nonmultiple head and neck carcinomas2016
- Author(s)
  Ohtomo-Oda R, Komatsu S, Tsuda H et al.
- Journal Title
  
  Hum Pathol
  
  Volume: 49 Pages: 145-155
- DOI
  10.1016/j.humpath.2015.08.025
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-15K10112, KAKENHI-PROJECT-26460463, KAKENHI-PROJECT-23390469
[Journal Article] Frequent PTPRK-RSPO3 fusions and RNF43 mutations in colorectal traditional serrated adenoma.2016
- Author(s)
  Sekine S, Yamashita S, Tanabe T, Hashimoto T, Yoshida H, Taniguchi H, Kojima M, Shinmura K, Saito Y, Hiraoka N, Ushijima T, Ochiai A.
- Journal Title
  
  J Pathol
  
  Volume: 239 Issue: 2 Pages: 133-8
- DOI
  10.1002/path.4709
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460429
[Journal Article] Adult-onset inflammatory myofibroblastic tumour of the stomach with a TFG-ROS1 fusion. Histopathology.2015
- Author(s)
  Fujita H, Yoshida A, Taniguchi H, Katai H, Sekine S.
- Journal Title
  
  Histopathology
  
  Volume: Mar;66(4) Issue: 4 Pages: 610-2
- DOI
  10.1111/his.12575
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Familial adenomatous polyposis-associated and sporadic pyloric gland adenomas of the upper gastrointestinal tract share common genetic features2015
- Author(s)
  Hashimoto T, Ogawa R, Matsubara A, Taniguchi H, Sugano K, Ushiama M, Yoshida T, Kanai Y, Sekine S
- Journal Title
  
  Histopathology
  
  Volume: in press Issue: 5 Pages: 689-98
- DOI
  10.1111/his.12705
- Peer Reviewed / Acknowledgement Compliant
- Data Source
  KAKENHI-PROJECT-26460429
[Journal Article] Activating GNAS and KRAS mutations in gastric foveolar metaplasia, gastric heterotopia, and adenocarcinoma of the duodenum2015
- Author(s)
  Matsubara A, Ogawa R, Suzuki H, Oda I, Taniguchi H, Kanai Y, Kushima R, Sekine S
- Journal Title
  
  Br J Cancer
  
  Volume: 112 Issue: 8 Pages: 1398-404
- DOI
  10.1038/bjc.2015.104
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-26460429, KAKENHI-PROJECT-23390469
[Journal Article] .Frequent MED12 mutations in phyllodes tumours of the breast2015
- Author(s)
  Yoshida M, Sekine S, Ogawa R, Yoshida H, Maeshima A, Kanai Y, Kinoshita T, Ochiai A
- Journal Title
  
  Br J Cancer
  
  Volume: In press Issue: 10 Pages: 1703-1708
- DOI
  10.1038/bjc.2015.116
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast.2015
- Author(s)
  Yoshida M, Ogawa R, Yoshida H, Maeshima A, Kanai Y, Kinoshita T, Hiraoka N, Sekine S.
- Journal Title
  
  Br J Cancer
  
  Volume: Oct 20;113(8) Issue: 8 Pages: 1244-8
- DOI
  10.1038/bjc.2015.326
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma.2014
- Author(s)
  Sekine S, Ogawa R, Oshiro T, Kanemitsu Y, Taniguchi H, Kushima R, Kanai Y.
- Journal Title
  
  Genes Chromosomes Cancer
  
  Volume: Apr;53(4) Issue: 4 Pages: 366-72
- DOI
  10.1002/gcc.22147
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Intraductal dissemination of papillary adenocarcinoma of the2014
- Author(s)
  Matsubara A, Nara S, Sekine S, Ojima H, Kosuge T, Shimada K, Kushima R, Kanai
- Journal Title
  
  Pathol Int.
  
  Volume: Jan;64(1): Issue: 1 Pages: 39-44
- DOI
  10.1111/pin.12131
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Frequent lack of GNAS mutations in colorectal adenocarcinoma associated with GNAS-mutated villous adenoma.2014
- Author(s)
  Sekine S, Ogawa R, Oshiro T, Kanemitsu Y, Taniguchi H, Kushima R, Kanai Y.
- Journal Title
  
  Genes Chromosomes Cancer.
  
  Volume: 53(4):
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Utility of PAX8 mouse monoclonal antibody in the diagnosis of thyroid, thymic, pleural, and lung tumors: a comparison with polyclonal PAX8 antibody.2014
- Author(s)
  Toriyama A, Mori T, Sekine S, Yoshida A, Hino O, Tsuta K.
- Journal Title
  
  Histopathology
  
  Volume: On line Issue: 4 Pages: 465-72
- DOI
  10.1111/his.12405
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-25670868, KAKENHI-PROJECT-26460463, KAKENHI-PROJECT-221S0001
[Journal Article] Lobular endocervical glandular hyperplasia is a neoplastic entity with frequent activating GNAS mutations.2014
- Author(s)
  atsubara A, Sekine S, Ogawa R, Yoshida M, Kasamatsu T, Tsuda H, Kanai Y.
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 38(3) Issue: 3 Pages: 370-376
- DOI
  10.1097/pas.0000000000000093
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Frequent GNAS and KRAS mutations in pyloric gland adenoma of the stomach and duodenum.2013
- Author(s)
  Matsubara A,
- Journal Title
  
  J Pathol.
  
  Volume: 229 Issue: 4 Pages: 579-587
- DOI
  10.1002/path.4153
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-23590482
[Journal Article] Prevalence of MED12 mutations in uterine and extrauterine smooth muscle tumours. Histopathology.2013
- Author(s)
  Matsubara A
- Journal Title
  
  Histopathology.
  
  Volume: 62 Issue: 4 Pages: 657-661
- DOI
  10.1111/his.12039
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Soluble interleukin-6 receptor is a serum biomarker for the response of esophageal carcinoma to neoadjuvant chemoradiotherapy.2013
- Author(s)
  Makuuchi Y, Honda K, Osaka Y, Kato K, Kojima T, Daiko H, Igaki H, Ito Y, Hoshino S, Tachibana S, Watanabe T, Furuta K, Sekine S, Umaki T, Watabe Y, Miura N, Ono M, Tsuchida A, Yamada T.
- Journal Title
  
  Cancer Sci.
  
  Volume: Aug;104(8): Issue: 8 Pages: 1045-51
- DOI
  10.1111/cas.12187
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590482, KAKENHI-PROJECT-25670868
[Journal Article] Gastric adenocarcinoma of the fundic gland type shares common genetic and phenotypic features with pyloric gland adenoma.2013
- Author(s)
  Kushima R, Sekine S, Matsubara A, Taniguchi H, Ikegami M, Tsuda H.
- Journal Title
  
  Pathol Int
  
  Volume: ;63(6) Issue: 6 Pages: 318-25
- DOI
  10.1111/pin.12070
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Frequent GNAS mutations in low-grade appendiceal mucinous neoplasms.2013
- Author(s)
  Nishikawa G, Sekine S, Ogawa R, Matsubara A, Mori T, Taniguchi H, Kushima R, Hiraoka N, Tsuta K, Tsuda H, Kanai Y.
- Journal Title
  
  Br J Cancer.
  
  Volume: Mar 5;108(4): Issue: 4 Pages: 951-8
- DOI
  10.1038/bjc.2013.47
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-25670868
[Journal Article] Risk factors for lymphatic and venous involvement in endoscopically resected gastric cancer.2013
- Author(s)
  Sekiguchi M, Sekine S, Oda I, Nonaka S, Suzuki H, Yoshinaga S, Taniguchi H, Tsuda H, Kushima R, Saito Y.
- Journal Title
  
  J Gastroenterol.
  
  Volume: 48(6) Issue: 6 Pages: 706-12
- DOI
  10.1007/s00535-012-0696-7
- NAID
  10031184060
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Bile Acids Increase Levels of microRNAs 221 and 222, Leading to Degradation of CDX2 During Esophageal Carcinogenesis2013
- Author(s)
  J. Matsuzaki, H. Suzuki, H. Tsugawa, M. Watanabe, S. Hossain, T. Akaike, T. Hibi, et. al.
- Journal Title
  
  Gastroenterology
  
  Volume: (In Press) Issue: 6 Pages: 1300-1311
- DOI
  10.1053/j.gastro.2013.08.008
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-11F01350, KAKENHI-PROJECT-23220014, KAKENHI-PROJECT-23580139, KAKENHI-PROJECT-23590482, KAKENHI-PROJECT-23680090, KAKENHI-PROJECT-24659103, KAKENHI-PROJECT-25293178, KAKENHI-PROJECT-25460173, KAKENHI-PROJECT-25460487
[Journal Article] Clinicopathological characteristics and prognostic factors of advanced colorectal mucinous adenocarcinoma.2012
- Author(s)
  Yamaguchi T
- Journal Title
  
  Histopathology
  
  Volume: 61 Issue: 2 Pages: 162-169
- DOI
  10.1111/j.1365-2559.2012.04235.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Frequent activating GNAS mutations in villous adenoma of the colorectum.2012
- Author(s)
  Yamada M
- Journal Title
  
  J Pathol.
  
  Volume: 228 Issue: 1 Pages: 113-118
- DOI
  10.1002/path.4012
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Histologic and immunohistochemical analyses of α-fetoprotein--producing cancer of the stomach.2012
- Author(s)
  Kinjo T
- Journal Title
  
  Am J Surg Pathol.
  
  Volume: 36 Issue: 1 Pages: 56-65
- DOI
  10.1097/pas.0b013e31823aafec
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Induction of the stem-like cell regulator CD44 by Rho kinase inhibition contributes to the maintenance of colon cancer-initiating cells.2012
- Author(s)
  Hirokazu Ohata
- Journal Title
  
  Cancer Research
  
  Volume: 72 Issue: 19 Pages: 5101-5110
- DOI
  10.1158/0008-5472.can-11-3812
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22590299, KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376, KAKENHI-PROJECT-24790727, KAKENHI-PUBLICLY-23112523
[Journal Article] NKX2.2 is a useful immunohistochemical marker for Ewing sarcoma.2012
- Author(s)
  Yoshida A
- Journal Title
  
  Am J SurgPathol.
  
  Volume: 36 Issue: 7 Pages: 993-999
- DOI
  10.1097/pas.0b013e31824ee43c
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Anal canal neuroendocrine carcinoma associated with squamous intraepithelial neoplasia: a human papillomavirus 18-related lesion.2012
- Author(s)
  Ohtomo R
- Journal Title
  
  Pathol Int.
  
  Volume: 62 Issue: 5 Pages: 356-359
- DOI
  10.1111/j.1440-1827.2012.02800.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469, KAKENHI-PROJECT-23590376
[Journal Article] Identification of adipophilin as a potential plasma biomarker for colorectal cancer using label-free quantitative mass spectrometry and protein microarray2011
- Author(s)
  Matsubara J, Honda K, Ono M, Sekine S, Tanaka Y, Kobayashi M, Jung G, Sakuma T, Nakamori S, Sata N, Nagai H, Ioka T, Okusaka T, Kosuge T, Tsuchida A, Shimahara M, Yasunami Y, Chiba T, Yamada T
- Journal Title
  
  Cancer Epidemiol Biomarkers Prev
  
  Volume: 20(10) Pages: 2195-2203
- NAID
  120005593640
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23390469
[Journal Article] Expression of SLCO1B3 is associated with intratumoral cholestasis and CTNNB1 mutations in hepatocellular carcinoma2011
- Author(s)
  Sekine S, Ogawa R, Ojima H, Kanai Y
- Journal Title
  
  Cancer Sci
  
  Volume: 102(9) Issue: 9 Pages: 1742-7
- DOI
  10.1111/j.1349-7006.2011.01990.x
- NAID
  10030243397
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590482
[Journal Article] Overexpression ofα-methylacyl-CoA racemase is associated with CTNNB1 mutations in hepatocellular carcinomas2011
- Author(s)
  Sekine S, Ogawa R, Ojima H, Kanai Y
- Journal Title
  
  Histopathology
  
  Volume: 58(5) Issue: 5 Pages: 712-9
- DOI
  10.1111/j.1365-2559.2011.03798.x
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590482
[Journal Article] Hepatomas with activating Ctnnb1 mutations in 'Ctnnb1-deficient' livers : a tricky aspect of a conditional knockout mouse model2011
- Author(s)
  Sekine S, Ogawa R, Kanai Y
- Journal Title
  
  Carcinogenesis
  
  Volume: 32(4) Issue: 4 Pages: 622-8
- DOI
  10.1093/carcin/bgr002
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-23590482
[Journal Article] Dicer is required for proper liver zonation2009
- Author(s)
  Sekine S, et al.
- Journal Title
  
  J Pathol 219
  
  Pages: 365-372
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20790315
[Journal Article] Dicer is required for proper liver zonation2009
- Author(s)
  Sekine S, Ogawa R, Mcmanus MT, Kanai Y, Hebrok M.
- Journal Title
  
  J Pathol. 219
  
  Pages: 365-372
- Data Source
  KAKENHI-PROJECT-20790315
[]
[]

1. 下重美紀 (00392340)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
2. Kazufumi Honda (10260936)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
3. MORI Taisuke (00296708)

# of Collaborated Projects: 1 results

# of Collaborated Products: 3 results
4. HIRAOKA Nobuyoshi (40276217)

# of Collaborated Projects: 1 results

# of Collaborated Products: 2 results
5. WATABE Yukio (50733490)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
6. IZUMO Toshiyuki (80322709)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
7. 八木原一博 (00538126)

# of Collaborated Projects: 1 results

# of Collaborated Products: 0 results
8. KOMATSU Shuhei

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
9. 山田真善

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
10. 谷田部恭

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
11. HOSSAIN M.S.

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
12. HOSSAIN Md. Shariff

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results
13. HOSSAIN Md.Sharif

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

Sekine Shigeki 関根 茂樹

SEKINE Shigeki 関根 茂樹

関根 茂樹 セキネ シゲキ

Research Projects

Research Products

Co-Researchers

Molecular analysis of duodenal carcinogenesisPrincipal Investigator

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WNT pathway-related genetic alterations in colorectal tumorsPrincipal Investigator

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GNAS mutations in gastrointestinal tumorsPrincipal Investigator

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Development of novel molecular targets for oral cancer with kinome profile by antibody-based proteomics

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ＴＮＩＫ遺伝子欠損マウス開発による大腸発がん制御機構解明と標的薬の副作用発現予測

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Analysis of tumor suppressive effects of miRNA using Dicer-deficient micePrincipal Investigator

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Role of β-catenin in the liver and liver cancerPrincipal Investigator

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胃癌における既知癌遺伝子・癌抑制遺伝子変異および病理組織像の総合的解析Principal Investigator

Principal Investigator

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相同組み換えを用いた変異β-catenin・p53のヒト腫瘍における機能解析Principal Investigator

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[Journal Article] APC mutations are common in adenomas but infrequent in adenocarcinomas of the non-ampullary duodenum2021

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[Journal Article] Clinicopathological and molecular correlations in traditional serrated adenoma2020

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[Journal Article] Clinicopathologic and Molecular Characteristics of Familial Adenomatous Polyposis?associated Traditional Serrated Adenoma2020

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[Journal Article] Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp2018

Author(s)

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Sekine Shigeki 関根茂樹

SEKINE Shigeki 関根茂樹

関根茂樹セキネシゲキ