FUJII Ryoji 藤井亮爾

… Alternative Names

藤井亮爾フジイリヨウジ

Less

Researcher Number	10333535
Other IDs
Affiliation (Current)	2025: 聖マリアンナ医科大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help	2020 – 2024: 聖マリアンナ医科大学, 医学研究科, 准教授 2016: 聖マリアンナ医科大学, 医学研究科, 講師 2010 – 2015: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師 2001 – 2002: 聖マリアンナ医科大学, 難病治療研究センター, 助手
Review Section/Research Field	Principal Investigator Basic Section 56020:Orthopedics-related / Biological Sciences / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学 Except Principal Investigator Basic Section 56020:Orthopedics-related
Keywords	Principal Investigator 関節リウマチ / SPACIA1 / CDK6 / 炎症 / 細胞増殖 / 滑膜炎 / 転写統合装置 / RNAヘリケースA / 感染症 / 核酸 … More / 遺伝子 / 滑膜細胞増殖 / コラーゲン誘導関節炎 / リウマチ / 滑膜 / 滑膜細胞 / 細胞分子生物学 / リウマチ学 / ウイルス / 発現制御 / HIV / 発現抑制 / HIVウイルス … More Except Principal Investigator 軟骨細胞 / 変形性関節症 / 細胞エネルギー代謝 / 軟骨変性 / 荷重ストレス / 力学的ストレス / エネルギー代謝 / 核酸 / 軟骨 / まかにかるストレス / 核酸損傷修復酵素 / 機械的ストレス / メカニカルストレス / 細胞エネルギー / 長寿遺伝子関連蛋白 / 核酸修復酵素 / 軟骨代謝 Less

SPACIA1依存的関節リウマチのバイオマーカー、治療薬候補の検証・特性調査Principal Investigator
- Principal Investigator
  
  藤井亮爾
- Project Period (FY)
  2024 – 2026
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  St. Marianna University School of Medicine
生理的・病的荷重ストレスに応答する軟骨のエネルギー代謝と核酸修復の相関、治療応用
- Principal Investigator
  
  遊道和雄
- Project Period (FY)
  2023 – 2025
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  St. Marianna University School of Medicine
難治性SPACIA1依存的関節リウマチのバイオマーカー探索と薬剤標的の検討Principal Investigator
- Principal Investigator
  
  藤井亮爾
- Project Period (FY)
  2021 – 2024
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  St. Marianna University School of Medicine
Mechanical stress mediates the DNA repair enzyme and energy metabolism in chondrocytes in osteoarthritis.
- Principal Investigator
  
  Kazuo Yudo
- Project Period (FY)
  2020 – 2023
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Review Section
  
  Basic Section 56020:Orthopedics-related
- Research Institution
  St. Marianna University School of Medicine
Potential of SPACIA1 as a druggable target of rheumatoid arthritisPrincipal Investigator
- Principal Investigator
  
  Fujii Ryoji
- Project Period (FY)
  2013 – 2016
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  Collagenous pathology/Allergology
- Research Institution
  St. Marianna University School of Medicine
Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.Principal Investigator
- Principal Investigator
  
  FUJII Ryoji
- Project Period (FY)
  2010 – 2012
- Research Category
  
  Grant-in-Aid for Scientific Research (C)
- Research Field
  
  膠原病・アレルギー・感染症内科学
- Research Institution
  St. Marianna University School of Medicine
翻訳反応におけるRNAヘリケースA/ウイルスmRNA複合体の生物学的意義の解明Principal Investigator
- Principal Investigator
  
  藤井亮爾
- Project Period (FY)
  2002
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas
- Review Section
  
  Biological Sciences
- Research Institution
  St. Marianna University School of Medicine
転写統合装置の機能調節を目的としたHIVウイルスTAR RNAのトロピズム解析Principal Investigator
- Principal Investigator
  
  藤井亮爾
- Project Period (FY)
  2001
- Research Category
  
  Grant-in-Aid for Scientific Research on Priority Areas (C)
- Review Section
  
  Biological Sciences
- Research Institution
  St. Marianna University School of Medicine

All 2024 2023 2022 2021 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation

[Journal Article] Mitochondrial Ubiquitin Ligase Activator of NF-κB (MULAN) regulates NF-κB signaling in ER stress-stimulated cells.2016
- Author(s)
  Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K and Nakajima T
- Journal Title
  
  Int J Mol Med.
  
  Volume: 37 Issue: 6 Pages: 1611-1618
- DOI
  10.3892/ijmm.2016.2566
- Peer Reviewed / Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-25461490, KAKENHI-PROJECT-26461478
[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012
- Author(s)
  Fujii R, Komatsu R, Sato T, Yagishita N, Aratani S, Araya N, Nishikawa H, Yamano Y, Yudoh K,Beppu M, Nishioka K, Nakajima T
- Journal Title
  
  J St. Marianna Univ.
  
  Volume: 40(2) Pages: 51-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591088
[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation-Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012
- Author(s)
  Fujii Ryoji
- Journal Title
  
  J St. Marianna Univ.
  
  Volume: 40 Pages: 51-56
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-22591088
[Journal Article] Overexpression of SPACIA1/SAAL1, a new gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans2011
- Author(s)
  佐藤知雄、中島利博, 他11名
- Journal Title
  
  Arthritis Rheum
  
  Volume: 63 Issue: 12 Pages: 3833-3842
- DOI
  10.1002/art.30617
- Peer Reviewed
- Data Source
  KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22591088, KAKENHI-PROJECT-22790833, KAKENHI-PROJECT-23659176
[Presentation] TNFα誘導性滑膜線維芽細胞増殖における抗リウマチ薬によるRBリン酸化制御の違い2024
- Author(s)
  小松　梨恵，藤井　亮爾，仁木　久照，遊道　和雄
- Organizer
  第68回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] 滑膜細胞増殖を標的とした関節リウマチ治療におけるCDK6単独阻害の可能性2023
- Author(s)
  藤井亮爾, 小松梨恵, 鈴木由妃, 小笠原徹, 杉下陽堂, 仁木久照, 遊道和雄
- Organizer
  第38回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] CDK6阻害剤とTNF阻害剤のin vitroおよびin vivoでの併用効果2023
- Author(s)
  小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
- Organizer
  第67回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] コラーゲン誘導関節炎マウスにおけるCDK6阻害剤とTNF阻害剤の併用効果2022
- Author(s)
  藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄
- Organizer
  第66回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] コラーゲン誘導関節炎マウスにおけるCDK6阻害剤とTNF阻害剤の併用効果2022
- Author(s)
  藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄
- Organizer
  第66回日本リウマチ学会総会・学術集会
- Data Source
  KAKENHI-PROJECT-20K09492
[Presentation] CDK6阻害剤とTNF阻害剤の併用による抗関節炎効果の検討2022
- Author(s)
  小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] CDK6阻害剤とTNF阻害剤の併用による抗関節炎効果の検討2022
- Author(s)
  小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
- Organizer
  第37回日本整形外科学会基礎学術集会
- Data Source
  KAKENHI-PROJECT-20K09492
[Presentation] TNFα誘導性滑膜線維芽細胞増殖を阻害するCDK6阻害剤の関節炎抑制効果2021
- Author(s)
  小松梨恵, 仁木久照, 遊道和雄, 藤井亮爾
- Organizer
  第65回日本リウマチ学会
- Data Source
  KAKENHI-PROJECT-21K09286
[Presentation] SPACIA1/SAAL1が制御するCDK6発現量の減少はRA滑膜細胞の増殖を抑制する2017
- Author(s)
  小松梨恵、遊道和雄、仁木久照、西岡久寿樹、中島利博、藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  福岡国際会議場（福岡県福岡市）
- Data Source
  KAKENHI-PROJECT-25461490
[Presentation] SPACIA1/SAAL1の遺伝子欠損はコラーゲン誘導関節炎モデルにおける関節炎の進展を軽減する2016
- Author(s)
  小松梨恵、關巌、佐藤知雄、青野浩之、山野嘉久、遊道和雄、仁木久照、西岡久寿樹、中島利博、藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  パシフィコ横浜（神奈川県横浜市）
- Data Source
  KAKENHI-PROJECT-25461490
[Presentation] Effect of CDK6 inhibitor on mice collagen-induced arthritis model.2015
- Author(s)
  Rie Komatsu, Tomoo Sato, Yoshihisa Yamano, Kazuo Yudoh, Moroe Beppu, Kusuki Nishioka, Toshihiro Nakajima, Ryoji Fujii
- Organizer
  第５９回日本リウマチ学会
- Place of Presentation
  名古屋国際会議場（愛知県名古屋市）
- Year and Date
  2015-04-23
- Data Source
  KAKENHI-PROJECT-25461490
[Presentation] SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis.2015
- Author(s)
  Ryoji Fujii, Iwao Seki, Rie Komatsu, Miwa Takai, Tomomi Kohara, Tomoo Sato, Kohji Konomi, Hiroyuki Aono, Kazuo Yudoh, Kusuki Nishioka, Toshihiro Nakajima
- Organizer
  American College of Rheumatology
- Place of Presentation
  San Francisco, USA
- Year and Date
  2015-11-10
- Int'l Joint Research
- Data Source
  KAKENHI-PROJECT-25461490
[Presentation] Analysis of a transcriptional complex on the core promoter of SPACIA1 gene, which associated with synovitis.2013
- Author(s)
  藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  京都国際会館
- Data Source
  KAKENHI-PROJECT-25461490
[Presentation] Analysis of a core promoter context of SPACIA1/SAAL1 gene which is related to synovitis2012
- Author(s)
  藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都)
- Year and Date
  2012-04-26
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] Analysis of a core promoter context of SPACIA1/SAAL1 gene which is related to synovitis.2012
- Author(s)
  藤井　亮爾
- Organizer
  日本リウマチ学会 (口演)
- Place of Presentation
  グランドプリンスホテル新高輪（東京都）
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] A newly identified gene, SPACIA1, that is related to synovitis2011
- Author(s)
  Ryoji Fujii
- Organizer
  Tokyo-Shanghai Workshop on Rheumatology 2011
- Place of Presentation
  千葉県
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] リウマチ滑膜新規増殖因子SPACTA1のプロモーター解析2011
- Author(s)
  藤井亮爾
- Organizer
  第32回日本炎症・再生医学会
- Place of Presentation
  京都府
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] A newly identified gene, SPACIA1, that is related to synovitis2011
- Author(s)
  藤井亮爾
- Organizer
  Tokyo-Shanghai Workshop on Rheumatology 2011
- Place of Presentation
  ヒルトン東京ベイホテル(千葉県)
- Year and Date
  2011-11-13
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] リウマチ滑膜新規増殖因子SPACIA1 のプロモーター解析2011
- Author(s)
  藤井亮爾
- Organizer
  日本炎症・再生医学会
- Place of Presentation
  京都国際会館(京都府)
- Year and Date
  2011-06-03
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] リウマチ滑膜炎特異的に発現する新規滑膜増殖因子SPACIA12010
- Author(s)
  藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] リウマチ滑膜炎特異的に発現する新規滑膜増殖因子SPACIA12010
- Author(s)
  藤井亮爾
- Organizer
  日本リウマチ学会
- Place of Presentation
  神戸ポートピアホテル(兵庫県)
- Year and Date
  2010-04-24
- Data Source
  KAKENHI-PROJECT-22591088
[Presentation] Functional CDK6 expression controlled by SPACIA1 in RA synoviocite proliferation.
- Author(s)
  Komatsu Rie, Sato Tomoo, Yamano Yoshihisa, Yudoh Kazuo, Beppu Moroe, Nishioka Kusuki Nakajima Toshihiro, Fujii Ryoji
- Organizer
  日本リウマチ学会
- Place of Presentation
  グランドプリンスホテル新高輪(東京都港区)
- Year and Date
  2014-04-24 – 2014-04-26
- Data Source
  KAKENHI-PROJECT-25461490

1. YUDO Kazuo (60272928)

# of Collaborated Projects: 3 results

# of Collaborated Products: 7 results
2. SATO Tomoo (30387063)

# of Collaborated Projects: 2 results

# of Collaborated Products: 1 results
3. KOMATSU Rie (80517475)

# of Collaborated Projects: 2 results

# of Collaborated Products: 6 results
4. 中島利博 (90260752)

# of Collaborated Projects: 2 results

# of Collaborated Products: 2 results
5. 唐澤里江 (50434410)

# of Collaborated Projects: 2 results

# of Collaborated Products: 0 results
6. YAMANO Yoshihisa (80445882)

# of Collaborated Projects: 1 results

# of Collaborated Products: 1 results
7. 荒谷聡子

# of Collaborated Projects: 0 results

# of Collaborated Products: 1 results

FUJII Ryoji 藤井 亮爾

藤井 亮爾 フジイ リヨウジ

Research Projects

Research Products

Co-Researchers

SPACIA1依存的関節リウマチのバイオマーカー、治療薬候補の検証・特性調査Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

生理的・病的荷重ストレスに応答する軟骨のエネルギー代謝と核酸修復の相関、治療応用

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

難治性SPACIA1依存的関節リウマチのバイオマーカー探索と薬剤標的の検討Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Mechanical stress mediates the DNA repair enzyme and energy metabolism in chondrocytes in osteoarthritis.

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

Potential of SPACIA1 as a druggable target of rheumatoid arthritisPrincipal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Research Field

Research Institution

翻訳反応におけるRNAヘリケースA/ウイルスmRNA複合体の生物学的意義の解明Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

転写統合装置の機能調節を目的としたHIVウイルスTAR RNAのトロピズム解析Principal Investigator

Principal Investigator

Project Period (FY)

Research Category

Review Section

Research Institution

[Journal Article] Mitochondrial Ubiquitin Ligase Activator of NF-κB (MULAN) regulates NF-κB signaling in ER stress-stimulated cells.2016

Author(s)

Journal Title

DOI

Data Source

[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012

Author(s)

Journal Title

Data Source

[Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation-Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012

Author(s)

Journal Title

Data Source

[Journal Article] Overexpression of SPACIA1/SAAL1, a new gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans2011

Author(s)

Journal Title

DOI

Data Source

[Presentation] TNFα誘導性滑膜線維芽細胞増殖における抗リウマチ薬によるRBリン酸化制御の違い2024

Author(s)

Organizer

Data Source

[Presentation] 滑膜細胞増殖を標的とした関節リウマチ治療におけるCDK6単独阻害の可能性2023

Author(s)

Organizer

Data Source

[Presentation] CDK6阻害剤とTNF阻害剤のin vitroおよびin vivoでの併用効果2023

FUJII Ryoji 藤井亮爾

藤井亮爾フジイリヨウジ