• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

FUJII Ryoji  藤井 亮爾

ORCIDConnect your ORCID iD *help
… Alternative Names

藤井 亮爾  フジイ リヨウジ

Less
Researcher Number 10333535
Other IDs
Affiliation (Current) 2025: 聖マリアンナ医科大学, 医学研究科, 准教授
Affiliation (based on the past Project Information) *help 2020 – 2024: 聖マリアンナ医科大学, 医学研究科, 准教授
2016: 聖マリアンナ医科大学, 医学研究科, 講師
2010 – 2015: 聖マリアンナ医科大学, 医学(系)研究科(研究院), 講師
2001 – 2002: 聖マリアンナ医科大学, 難病治療研究センター, 助手
Review Section/Research Field
Principal Investigator
Basic Section 56020:Orthopedics-related / Biological Sciences / Collagenous pathology/Allergology / 膠原病・アレルギー・感染症内科学
Except Principal Investigator
Basic Section 56020:Orthopedics-related
Keywords
Principal Investigator
関節リウマチ / SPACIA1 / CDK6 / 炎症 / 細胞増殖 / 滑膜炎 / 転写統合装置 / RNAヘリケースA / 感染症 / 核酸 … More / 遺伝子 / 滑膜細胞増殖 / コラーゲン誘導関節炎 / リウマチ / 滑膜 / 滑膜細胞 / 細胞分子生物学 / リウマチ学 / ウイルス / 発現制御 / HIV / 発現抑制 / HIVウイルス … More
Except Principal Investigator
軟骨細胞 / 変形性関節症 / 細胞エネルギー代謝 / 軟骨変性 / 荷重ストレス / 力学的ストレス / エネルギー代謝 / 核酸 / 軟骨 / まかにかるストレス / 核酸損傷修復酵素 / 機械的ストレス / メカニカルストレス / 細胞エネルギー / 長寿遺伝子関連蛋白 / 核酸修復酵素 / 軟骨代謝 Less
  • Research Projects

    (8 results)
  • Research Products

    (26 results)
  • Co-Researchers

    (7 People)
  •  SPACIA1依存的関節リウマチのバイオマーカー、治療薬候補の検証・特性調査Principal Investigator

    • Principal Investigator
      藤井 亮爾
    • Project Period (FY)
      2024 – 2026
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      St. Marianna University School of Medicine
  •  生理的・病的荷重ストレスに応答する軟骨のエネルギー代謝と核酸修復の相関、治療応用

    • Principal Investigator
      遊道 和雄
    • Project Period (FY)
      2023 – 2025
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      St. Marianna University School of Medicine
  •  難治性SPACIA1依存的関節リウマチのバイオマーカー探索と薬剤標的の検討Principal Investigator

    • Principal Investigator
      藤井 亮爾
    • Project Period (FY)
      2021 – 2024
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      St. Marianna University School of Medicine
  •  Mechanical stress mediates the DNA repair enzyme and energy metabolism in chondrocytes in osteoarthritis.

    • Principal Investigator
      Kazuo Yudo
    • Project Period (FY)
      2020 – 2023
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Review Section
      Basic Section 56020:Orthopedics-related
    • Research Institution
      St. Marianna University School of Medicine
  •  Potential of SPACIA1 as a druggable target of rheumatoid arthritisPrincipal Investigator

    • Principal Investigator
      Fujii Ryoji
    • Project Period (FY)
      2013 – 2016
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      Collagenous pathology/Allergology
    • Research Institution
      St. Marianna University School of Medicine
  •  Study of novel factor, SPACIA1 which is expressed in synovial tissue in rheumatoid arthritis.Principal Investigator

    • Principal Investigator
      FUJII Ryoji
    • Project Period (FY)
      2010 – 2012
    • Research Category
      Grant-in-Aid for Scientific Research (C)
    • Research Field
      膠原病・アレルギー・感染症内科学
    • Research Institution
      St. Marianna University School of Medicine
  •  翻訳反応におけるRNAヘリケースA/ウイルスmRNA複合体の生物学的意義の解明Principal Investigator

    • Principal Investigator
      藤井 亮爾
    • Project Period (FY)
      2002
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas
    • Review Section
      Biological Sciences
    • Research Institution
      St. Marianna University School of Medicine
  •  転写統合装置の機能調節を目的としたHIVウイルスTAR RNAのトロピズム解析Principal Investigator

    • Principal Investigator
      藤井 亮爾
    • Project Period (FY)
      2001
    • Research Category
      Grant-in-Aid for Scientific Research on Priority Areas (C)
    • Review Section
      Biological Sciences
    • Research Institution
      St. Marianna University School of Medicine

All 2024 2023 2022 2021 2017 2016 2015 2013 2012 2011 2010 Other

All Journal Article Presentation

  • [Journal Article] Mitochondrial Ubiquitin Ligase Activator of NF-κB (MULAN) regulates NF-κB signaling in ER stress-stimulated cells.2016

    • Author(s)
      Fujita H, Aratani S, Fujii R, Yamano Y, Yagishita N, Araya N, Izumi T, Azakami K, Hasegawa D, Nishioka K and Nakajima T
    • Journal Title

      Int J Mol Med.

      Volume: 37 Issue: 6 Pages: 1611-1618

    • DOI

      10.3892/ijmm.2016.2566

    • Peer Reviewed / Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-26461476, KAKENHI-PROJECT-15K15091, KAKENHI-PROJECT-26670479, KAKENHI-PROJECT-25305032, KAKENHI-PROJECT-16H05157, KAKENHI-PROJECT-16H05845, KAKENHI-PROJECT-25461490, KAKENHI-PROJECT-26461478
  • [Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation- Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012

    • Author(s)
      Fujii R, Komatsu R, Sato T, Yagishita N, Aratani S, Araya N, Nishikawa H, Yamano Y, Yudoh K,Beppu M, Nishioka K, Nakajima T
    • Journal Title

      J St. Marianna Univ.

      Volume: 40(2) Pages: 51-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Journal Article] Analysis of a Core Promoter Context of Synoviocyte Proliferation-Associated in Collagen Induced Arthritis 1 (SPACIA1) Gene Associated with Synovitis.2012

    • Author(s)
      Fujii Ryoji
    • Journal Title

      J St. Marianna Univ.

      Volume: 40 Pages: 51-56

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Journal Article] Overexpression of SPACIA1/SAAL1, a new gene that is involved in synoviocyte proliferation, accelerates the progression of synovitis in mice and humans2011

    • Author(s)
      佐藤知雄、中島利博, 他11名
    • Journal Title

      Arthritis Rheum

      Volume: 63 Issue: 12 Pages: 3833-3842

    • DOI

      10.1002/art.30617

    • Peer Reviewed
    • Data Source
      KAKENHI-PROJECT-20249052, KAKENHI-PROJECT-22590943, KAKENHI-PROJECT-22591088, KAKENHI-PROJECT-22790833, KAKENHI-PROJECT-23659176
  • [Presentation] TNFα誘導性滑膜線維芽細胞増殖における抗リウマチ薬によるRBリン酸化制御の違い2024

    • Author(s)
      小松 梨恵,藤井 亮爾,仁木 久照,遊道 和雄
    • Organizer
      第68回日本リウマチ学会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] 滑膜細胞増殖を標的とした関節リウマチ治療におけるCDK6単独阻害の可能性2023

    • Author(s)
      藤井亮爾, 小松梨恵, 鈴木由妃, 小笠原徹, 杉下陽堂, 仁木久照, 遊道和雄
    • Organizer
      第38回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] CDK6阻害剤とTNF阻害剤のin vitroおよびin vivoでの併用効果2023

    • Author(s)
      小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
    • Organizer
      第67回日本リウマチ学会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] コラーゲン誘導関節炎マウスにおけるCDK6阻害剤とTNF阻害剤の併用効果2022

    • Author(s)
      藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄
    • Organizer
      第66回日本リウマチ学会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] コラーゲン誘導関節炎マウスにおけるCDK6阻害剤とTNF阻害剤の併用効果2022

    • Author(s)
      藤井亮爾, 小松梨恵, 仁木久照, 遊道和雄
    • Organizer
      第66回日本リウマチ学会総会・学術集会
    • Data Source
      KAKENHI-PROJECT-20K09492
  • [Presentation] CDK6阻害剤とTNF阻害剤の併用による抗関節炎効果の検討2022

    • Author(s)
      小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
    • Organizer
      第37回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] CDK6阻害剤とTNF阻害剤の併用による抗関節炎効果の検討2022

    • Author(s)
      小松梨恵, 藤井亮爾, 仁木久照, 遊道和雄
    • Organizer
      第37回日本整形外科学会基礎学術集会
    • Data Source
      KAKENHI-PROJECT-20K09492
  • [Presentation] TNFα誘導性滑膜線維芽細胞増殖を阻害するCDK6阻害剤の関節炎抑制効果2021

    • Author(s)
      小松 梨恵, 仁木 久照, 遊道 和雄, 藤井 亮爾
    • Organizer
      第65回日本リウマチ学会
    • Data Source
      KAKENHI-PROJECT-21K09286
  • [Presentation] SPACIA1/SAAL1が制御するCDK6発現量の減少はRA滑膜細胞の増殖を抑制する2017

    • Author(s)
      小松梨恵、遊道和雄、仁木久照、西岡久寿樹、中島利博、藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      福岡国際会議場(福岡県福岡市)
    • Data Source
      KAKENHI-PROJECT-25461490
  • [Presentation] SPACIA1/SAAL1の遺伝子欠損はコラーゲン誘導関節炎モデルにおける関節炎の進展を軽減する2016

    • Author(s)
      小松梨恵、關巌、佐藤知雄、青野浩之、山野嘉久、遊道和雄、仁木久照、西岡久寿樹、中島利博、藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Data Source
      KAKENHI-PROJECT-25461490
  • [Presentation] Effect of CDK6 inhibitor on mice collagen-induced arthritis model.2015

    • Author(s)
      Rie Komatsu, Tomoo Sato, Yoshihisa Yamano, Kazuo Yudoh, Moroe Beppu, Kusuki Nishioka, Toshihiro Nakajima, Ryoji Fujii
    • Organizer
      第59回日本リウマチ学会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-04-23
    • Data Source
      KAKENHI-PROJECT-25461490
  • [Presentation] SPACIA1/SAAL1-Deficient Mice Show Reduced Disease Progression in Collagen-Induced Arthritis.2015

    • Author(s)
      Ryoji Fujii, Iwao Seki, Rie Komatsu, Miwa Takai, Tomomi Kohara, Tomoo Sato, Kohji Konomi, Hiroyuki Aono, Kazuo Yudoh, Kusuki Nishioka, Toshihiro Nakajima
    • Organizer
      American College of Rheumatology
    • Place of Presentation
      San Francisco, USA
    • Year and Date
      2015-11-10
    • Int'l Joint Research
    • Data Source
      KAKENHI-PROJECT-25461490
  • [Presentation] Analysis of a transcriptional complex on the core promoter of SPACIA1 gene, which associated with synovitis.2013

    • Author(s)
      藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      京都国際会館
    • Data Source
      KAKENHI-PROJECT-25461490
  • [Presentation] Analysis of a core promoter context of SPACIA1/SAAL1 gene which is related to synovitis2012

    • Author(s)
      藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      グランドプリンスホテ ル新高輪(東京都)
    • Year and Date
      2012-04-26
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] Analysis of a core promoter context of SPACIA1/SAAL1 gene which is related to synovitis.2012

    • Author(s)
      藤井 亮爾
    • Organizer
      日本リウマチ学会 (口演)
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都)
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] A newly identified gene, SPACIA1, that is related to synovitis2011

    • Author(s)
      Ryoji Fujii
    • Organizer
      Tokyo-Shanghai Workshop on Rheumatology 2011
    • Place of Presentation
      千葉県
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] リウマチ滑膜新規増殖因子SPACTA1のプロモーター解析2011

    • Author(s)
      藤井亮爾
    • Organizer
      第32回日本炎症・再生医学会
    • Place of Presentation
      京都府
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] A newly identified gene, SPACIA1, that is related to synovitis2011

    • Author(s)
      藤井亮爾
    • Organizer
      Tokyo-Shanghai Workshop on Rheumatology 2011
    • Place of Presentation
      ヒルトン東京ベイホテル(千 葉県)
    • Year and Date
      2011-11-13
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] リウマチ滑膜新規増殖因子SPACIA1 のプロモーター解析2011

    • Author(s)
      藤井亮爾
    • Organizer
      日本炎症・再生医学会
    • Place of Presentation
      京都国際会館(京都府)
    • Year and Date
      2011-06-03
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] リウマチ滑膜炎特異的に発現する新規滑膜増殖因子SPACIA12010

    • Author(s)
      藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] リウマチ滑膜炎特異的に発現す る新規滑膜増殖因子SPACIA12010

    • Author(s)
      藤井亮爾
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県)
    • Year and Date
      2010-04-24
    • Data Source
      KAKENHI-PROJECT-22591088
  • [Presentation] Functional CDK6 expression controlled by SPACIA1 in RA synoviocite proliferation.

    • Author(s)
      Komatsu Rie, Sato Tomoo, Yamano Yoshihisa, Yudoh Kazuo, Beppu Moroe, Nishioka Kusuki Nakajima Toshihiro, Fujii Ryoji
    • Organizer
      日本リウマチ学会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Year and Date
      2014-04-24 – 2014-04-26
    • Data Source
      KAKENHI-PROJECT-25461490
  • 1.  YUDO Kazuo (60272928)
    # of Collaborated Projects: 3 results
    # of Collaborated Products: 7 results
  • 2.  SATO Tomoo (30387063)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 1 results
  • 3.  KOMATSU Rie (80517475)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 6 results
  • 4.  中島 利博 (90260752)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 2 results
  • 5.  唐澤 里江 (50434410)
    # of Collaborated Projects: 2 results
    # of Collaborated Products: 0 results
  • 6.  YAMANO Yoshihisa (80445882)
    # of Collaborated Projects: 1 results
    # of Collaborated Products: 1 results
  • 7.  荒谷 聡子
    # of Collaborated Projects: 0 results
    # of Collaborated Products: 1 results

URL: 

Are you sure that you want to link your ORCID iD to your KAKEN Researcher profile?
* This action can be performed only by the researcher himself/herself who is listed on the KAKEN Researcher’s page. Are you sure that this KAKEN Researcher’s page is your page?

この研究者とORCID iDの連携を行いますか?
※ この処理は、研究者本人だけが実行できます。

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi